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Agapova Maria M Pharmaceutical Outcomes Research and Policy Program, Department of Pharmacy, School of Pharmacy, University of Washington, 1959 NE Pacific St, Seattle, WA 98195. Electronic address: - - 2014
Health agencies making regulatory marketing-authorization decisions use qualitative and quantitative approaches to assess expected benefits and expected risks associated with medical interventions. There is, however, no universal standard approach that regulatory agencies consistently use to conduct benefit-risk assessment (BRA) for pharmaceuticals or medical devices, including for imaging technologies. Economics, health ...
Johnson Heidi H Department of Pediatrics, University of Nebraska Medical - - 2014
The study's aim was to determine migraine prevalence, severity, and educational impact in medical students. A 23-item survey of all medical students of one US medical school addressed migraine frequency, triggers, pattern and severity of symptoms, medication use, impact on educational activities and career choices. The response rate was 48% ...
Babelli Sumayah S University of Dundee , UK - - 2014
Abstract The Dundee Polyprofessionalism Inventory I: Academic Integrity was administered to 219 medical students from three Egyptian medical schools. The results indicate a high level of congruence between the genders in Recommended Sanctions on a scale of 1-10 ranging from Ignore through Reprimand to Expulsion/Report to Regulatory Body. Some variations ...
Van Hamel C C Health Education South West , - - 2014
Abstract Background: Mandatory induction for foundation year 1 trainees (F1s) was introduced in 2012 to ease the transition from student to doctor. The aims of this national study were to assess anxiety levels and preparedness in the 2012 F1 cohort and whether these varied according to medical school of graduation ...
Bonner Carissa - - 2014
Objective: Although current guidelines around the world recommend using absolute risk (AR) thresholds to decide whether cardiovascular disease (CVD) risk should be managed with lifestyle or medication, the use of AR in clinical practice is limited. The aim of this study was to explore the factors that influence general practitioner ...
Amin Alpesh A University of California, Irvine, - - 2014
Abstract OBJECTIVE: Results of randomized clinical trials (RCT) demonstrate that novel oral anticoagulants (NOAC) are effective therapies for reducing the risk of stroke in non-valvular atrial fibrillation (NVAF). Prior medical cost avoidance studies have used warfarin event rates from RCTs, which may differ from patients receiving treatment in a real-world ...
Huang Lisu L Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, - - 2014
This study aimed to investigate early predictors (6months after diagnosis) of medical intractability in epilepsy. All children <12years of age having two or more unprovoked seizures 24h apart at Xinhua Hospital between 1992 and 2006 were included. Medical intractability was defined as failure, due to lack of seizure control, of ...
de la Torre Jack C JC Department of Psychology, University of Texas at Austin, Austin, Texas, - - 2014
The incidence rate in Alzheimer's disease (AD) is expected to quadruple worldwide by 2050. To limit this impending socio-medical calamity, a fulcrum change from how AD is presently managed is crucial. The present approach has not averted the stress of AD on medical resources nor reduced the already cost-strained government ...
Snipes Daniel J DJ Department of Psychology, Virginia Commonwealth University , Richmond, VA , - - 2014
Abstract Background: The non-medical use of prescription drugs (NMUPD) is a hazardous health behavior popular among young adults and college students. Past research has documented prevalence rates and risk factors associated with NMUPD, while little research has addressed protective factors. Objective: The present study examined the associations of religiosity and ...
Blalock Susan J SJ Division of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy, University of North Carolina at Chapel - - 2014
Objective: We use a multidimensional framework to describe the types of information about medication risks that rheumatologists provide to rheumatoid arthritis (RA) patients during routine office. Methods: We analyzed 1,094 audio-taped rheumatology office visits involving 450 RA patients. Each patient had up to three visits audiotaped. In conjunction with each ...
Nakamura Koshi K Department of Epidemiology and Public Health, Kanazawa Medical - - 2014
Concerns have increasingly been raised about the medical economic burden in Japan, of which approximately 20% is attributable to cardiovascular disease, including coronary heart disease and stroke. Because the management of risk factors is essential for the prevention of cardiovascular disease, it is important to understand the relationship between cardiovascular ...
Nakamura Koshi K Koshi Nakamura, Department of Epidemiology and Public Health, Kanazawa Medical University, Ishikawa 920-0293, - - 2014
Hypertension is a major determinant of health and is likely to have an effect on medical economics. The economic burden due to hypertension may be attributable not only to antihypertensive medication but also to the very expensive procedures required for cases of cardiovascular disease that occur more frequently in hypertensive ...
Claydon-Platt Kate K PhD Researcher, Melbourne School of Health Sciences, The University of Melbourne, Level 6, Alan, Gilbert Building, 161 Barry Street, Carlton Victoria Australia 3010. Phone: +61 3 8344 9463, Fax: +61 3 8344 5391 Email: - - 2014
Abstract Aims: To develop and evaluate a screening tool to identify people with diabetes at increased risk of medication problems relating to hypoglycaemia and medication non-adherence. Methods: A retrospective audit of attendances at a diabetes outpatient clinic at a public, teaching hospital over a 16-month period was conducted. Logistic regression ...
Touma Waseem W Division of Hospital Medicine, Department of Internal Medicine, St. Louis, MO, United - - 2014
Cetuximab, a chimeric monoclonal antibody, is the only targeted therapy approved for squamous cell carcinoma of the head and neck (SCCHN). Infusion reactions (IRs) occur in 6-18% of patients pre-medicated with diphenhydramine. Evidence for clinical risk factors for IRs is limited and the benefit of additional pre-medication to prevent IRs ...
Chapman Christopher G CG Inflammatory Bowel Disease Center, University of Chicago Medicine, 5841 South Maryland Avenue, MC 4076, Chicago, IL 60637, - - 2014
It has been proposed that effective disease control through abrogation of inflammation in IBD may also reduce CRC risk in these individual patients. This article summarizes the potential for medical therapy to reduce the risk of CRC via primary and secondary prevention, and offers practical ways in which a goal ...
Kitzman Patrick - - 2014
Objective The purpose of this study was to examine the overall prevalence of polypharmacy within the spinal cord injury (SCI) population, the level of polypharmacy with respect to seven classes of high-risk drugs commonly used to treat secondary conditions in the SCI population, and the overall risks for drug-related problems ...
Willen Shaina M SM Department of Pediatrics, Duke University Medical Center, Durham, NC, - - 2014
Sickle cell disease (SCD) is the most common genetic disease among persons with African ancestry. This article provides a background to SCD and reviews many important aspects of travel preparation in this population. The medical literature was searched for studies on travel-associated preparedness and complications in individuals with SCD. Topics ...
Renata Grou Volpe Cris C Associate Professor of Nursing; University of Brasilia, - - 2014
This article describes the analysis of the frequency, type and risk factors relating to errors in the preparation and administration of medications in patients admitted to a public hospital in Brasilia Federal District, Brazil, which serves a population of approximately 500,000 inhabitants. Patients are commonly affected and harmed by medication ...
Urkin Jacob J Division of Community Health, Department of Family Medicine and Siaal Research Center for Family Practice and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O. Box 653, 84105, Beer-Sheva, Israel, - - 2014
Religiosity is inherent in human cultures. Being different in many aspects, all have rules regarding appropriate behavior and rituals. Celebrations of social events and of holidays prevail in all major religions. These include code of dress, prayers, special food and activities which may have negative health implications. The Jewish religion ...
Rome Benjamin N BN Program On Regulation, Therapeutics, And Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, 1620 Tremont St., Suite 3030, Boston, MA, 02120, USA, - - 2014
Since 1976, the US Food and Drug Administration (FDA) has used the premarket approval (PMA) process to approve high-risk medical devices, including implantable cardioverter defibrillators (ICDs), coronary stents, and artificial heart valves. The PMA process is widely viewed as a rigorous evaluation of device safety and effectiveness, though recent recalls-most ...
Schwabe Karen K Clinical Sport and Exercise Medicine Research Group, UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, , Cape Town, South - - 2014
The half-marathon (21 km) race is a very popular mass community-based distance running event. It is important to determine risk factors for medical complications during these events, so that prevention programmes can be developed. To determine risk factors associated with medical complications during 21 km road running events. Prospective study. ...
Schwabe Karen K Clinical Sport and Exercise Medicine Research Group, UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, , Cape Town, South - - 2014
It is important to identify risk factors associated with medical complications during ultra-marathons so that prevention programmes can be developed. To determine risk factors for medical complications during ultra-marathons. Prospective study. Two Oceans ultra-marathon (56 km) races. 26 354 race starters. Medical complications (defined as any runner requiring assessment by ...
Schnabel Marco Julius MJ University of Regensburg, Urology , Caritas Krankenhaus St. Josef , Landshuterstrasse 65 , Regensburg, Germany, 93053 ; - - 2014
Introduction: Shock wave lithotripsy (SWL) is the gold standard treatment of most renal and proximal ureter calculi. Severe bleeding complications in SWL are extremely rare. Uncorrected bleeding diathesis might increase the risk and is considered to be an absolute contraindication for SWL. Objective: Perioperative management of anticoagulative and antiplatelet therapy ...
Gendron Nicolas N Assistance Publique Hôpitaux de Paris, Service de Bactériologie, Centre National de Référence des Streptocoques, Hôpitaux Universitaires Paris Centre Cochin-Broca-Hôtel Dieu, Paris, - - 2014
Medical abortion is not recognized as a high risk factor for invasive pelvic infection. Here we report two cases of Group A Streptococcus (Streptococcus pyogenes; GAS) endometritis following medical abortions with a protocol of oral mifepristone and misoprostol.
Reich James J Department of Psychiatry, University of California, San Francisco, San Francisco, California, USA. E-mail: - - 2014
Our objective is to compare legal difficulties that psychiatrists encounter in regulatory agency and malpractice (insurance) settings. Data sources included a literature search of malpractice and medical board discipline from 1990 to 2009 (rates and types of discipline); publicly available insurance data (malpractice frequency and type); and data from the ...
Rojas-Fernandez Carlos H CH Schlegel-University of Waterloo Research Institute for Aging (Rojas-Fernandez, Brown), University of Waterloo, Waterloo, - - 2014
One-third to one-half of adults older than 65 fall at least once per year. Fall prevention through medication management requires little effort and has consistently been shown to reduce risk of falls. The objective of this study was to further develop and perform preliminary pilot testing of an algorithm designed ...
Katz Daniel H DH 1Department of Medicine, Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, - - 2014
With the release of the 2013 American College of Cardiology/American Heart Association (ACC/AHA) Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults, emphasis has been placed on using evidence-based intensity of therapy to reduce atherosclerotic cardiovascular disease (ASCVD) risk, rather than focusing on goal cholesterol ...
Fontana Marianna M International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, United - - 2014
Primary prevention guidelines focus on risk, often assuming negligible aversion to medication. Yet most subjects discontinue primary prevention statins within 3 years. We quantify real-world distribution of medication disutility, and separately calculate average utilities for a range of risk strata. We randomly sampled 360 members of the general public in ...
Huo Xiang X Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Acute Infectious Disease, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, - - 2014
Influenza remains one of the most important causes of respiratory infection despite the widespread availability of vaccines. Anti-influenza viral agents such as neuraminidase inhibitors are generally efficacious in alleviating the symptoms if they are administered within 2 days of the illness onset. However, few studies have examined the situation of ...
Kildare Leanne L Valley Family Medicine, Renton, WA, - - 2014
Both medications reduce the incidence of cardiovascular events in patients with hypertension, but chlorthalidone may confer additional cardiovascular risk reduction.
Carlson Josh J JJ Pharmaceutical Outcomes Research and Policy Program, University of Washington, Box 357630, Seattle, WA, 98195-7630, USA, - - 2014
Our objective was to identify and characterize publicly available cases and related trends for performance-based risk-sharing arrangements (PBRSAs). We performed a review of PBRSAs over the past 20 years (1993-2013) using available databases and reports from colleagues and healthcare experts. These were categorized according to a previously published taxonomy of scheme ...
Pankhurst T T Department of Nephrology, Queen Elizabeth Hospital Birmingham, Birmingham, - - 2014
Background/Aims: Acute kidney injury (AKI) following admission to hospital is associated with increased mortality, morbidity and length of stay. Factors that predispose patients to AKI frequently co-exist. The precise description of their representation in unselected admissions could help define mechanistic inter-relationships and optimise risk stratification strategies. Our aim was therefore ...
Daloiso V V Institute of Bioethics, "A. Gemelli" School of Medicine, Università Cattolica del Sacro Cuore, Rome, - - 2014
The aim of this preliminary survey was to picture the current knowledge and opinions of law students and medical students about nanotechnologies. Data were collected in June 2012 by interviews with 60 students of the University of Camerino (Macerata, Italy) defined as "jurist population" and 159 medical students of the ...
Falconer Nazanin N Nazanin Falconer, B.Pharm., PGCert, is Medication Safety Pharmacist; Sanjoy Nand, B.Pharm., M.Pharm., is Pharmacy Service Manager; Doreen Liow, B.Pharm., M.B.A., PGDip, is Clinical Pharmacy Manager; and Mary Seddon, M.B.Ch.B., is Clinical Director, Centre for Quality Improvement, Middlemore Hospital, Auckland, New Zealand. Aaron Jackson, B.Pharm., is Medication Management Manager, Orion Health, - - 2014
A software-based tool to help prioritize inpatients for adverse drug event (ADE) prevention initiatives is described. The clinical pharmacy department of a New Zealand hospital developed the Assessment of Risk Tool (ART), an application for monitoring prespecified clinical "flags" (some derived from the Institute for Healthcare Improvement's ADE trigger tool) ...
Gonzales Kelly K From the University of Nebraska Medical Center College of Nursing, Nebraska Medical Center, Omaha, - - 2014
To examine the relationship between risk propensity and safe medication administration, while also providing additional evidence of validity and reliability on the Safe Administration of Medication (SAM) Scale. A convenience sample of nursing students from a private Midwest university in the United States was invited to participate in the study. ...
Hall Joseph L - - 2014
The success of telehealth could be undermined if serious privacy and security risks are not addressed. For example, sensors that are located in a patient's home or that interface with the patient's body to detect safety issues or medical emergencies may inadvertently transmit sensitive information about household activities. Similarly, routine ...
Collins C Scott CS Division of General Internal Medicine, Mayo Clinic, Rochester, MN. - - 2014
The number, age, and medical complexity of patients undergoing elective noncardiac surgery is rising worldwide. Internists, family physicians, and midlevel providers asked to perform preoperative medical evaluations. However, lack of consensus has led to wide variation in practice in what is included and addressed in these evaluations, and the efficacy ...
Nelson Lewis S LS Department of Emergency Medicine, New York University School of Medicine, New York City Poison Control Center, 455 First Avenue, Room 123, New York, NY, 10016, USA, - - 2014
The decision to approve a drug for clinical use is based on an understanding of its benefits versus the risks. Although efficacy is generally understood at the time of submission to the FDA for approval, the risks are more difficult to assess. Both PubMed (from 2000 to 2012) and the ...
Cooper William O WO Departments of - - 2014
OBJECTIVES:Recent data showing possible increased risk for suicidal behavior among children and adolescents treated with selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) antidepressants have created significant concern among patients, families, and providers, including concerns about the risk of individual antidepressants. This study was designed to compare the ...
Hegarty Francis J - - 2014
Medical device interoperability has been identified as a key way of decreasing healthcare costs while improving patient care. 1 This has led to a shift toward placing more medical devices onto information technology (IT) networks. However, placing medical devices onto an IT network may lead to additional risks to safety, ...
Girela E E Department of Legal and Forensic Medicine, Faculty of Medicine, University of Córdoba, Avenida Menéndez Pidal s/n, 14071 Córdoba, - - 2014
We have studied the use of coercive medical measures (forced medication, isolation, and mechanical restraint) in mentally ill inmates within two secure psychiatric hospitals (SPH) and three regular prisons (RP) in Spain. Variables related to adopted coercive measures were analyzed, such as type of measure, causes of indication, opinion of ...
Makowsky Mark J MJ Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, - - 2014
Pharmacists working in primary care clinics are well positioned to help optimize medication management of community-dwelling patients who are at high risk of experiencing medication-related problems. However, it is often difficult to identify these patients. Our objective was to test the feasibility of a self-administered patient survey, to facilitate identification ...
Rees Christen C Roche Diagnostics Operations, Indianapolis, IN, USA christen.rees@gmail.com - - 2014
Several studies have shown the usefulness of an automated insulin dose bolus advisor (BA) in achieving improved glycemic control for insulin-using diabetes patients. Although regulatory agencies have approved several BAs over the past decades, these devices are not standardized in their approach to dosage calculation and include many features that ...
Redd Andrew A University of Utah, Department of Internal Medicine, Division of - - 2014
Early warning indicators to identify US Veterans at risk of homelessness are currently only inferred from administrative data. References to indicators of risk or instances of homelessness in the free text of medical notes written by Department of Veterans Affairs (VA) providers may precede formal identification of Veterans as being ...
Warren Jim J Department of Computer - - 2014
The Caring Does Matter (CDM) programme aimed to improve cardiovascular disease risk (CVR) management in Pacific people, targeting medication adherence problems. This paper presents cluster analysis of CDM data to model medication adherence and cardiovascular risk factors in high-CVR patients. Changes in cardiovascular medication adherence status and in physiological measures ...
Sadler John Z - - 2014
The essays on obesity in this issue frequently refer to the recent American Medical Association (AMA) declaration of obesity as a disease. In response to these essays, I describe and explore the significance of 'risk-factor medicalization' and how negative unintended consequences with this approach to disease modeling are exemplified in ...
Marcilly Romaric R INSERM CIC-IT, Lille ; Univ Lille Nord de France ; CHU Lille ; UDSL EA 2694 ; F-59000 Lille, - - 2014
The Medical Device regulation requires manufacturers to anticipate and prevent risks of use errors of their medical device. However, manufacturers experience difficulties to understand the concept of "usability-induced use-errors". Based on a "usability framework" aiming at describing the relationship between usability design principles, usability flaws, usage problems, and outcomes, a ...
Luukkonen Irmeli I University of Eastern Finland, School of Computing, Healthcare Information Systems Research and Development, Kuopio, - - 2014
Medication information management (MIM) is a crucial activity for good quality of medication, but unfortunately not without problems. In order to improve medication information management the core activity of medication as a cooperative activity is to be studied as a whole, and the multiprofessional viewpoint for the improvement needs must ...
Luukkonen Irmeli I University of Eastern Finland, School of Computing, Healthcare Information Systems Research and Development, Kuopio, - - 2014
Medication treatment and the related information management are central parts of a patient's health care. As a cross-organizational and cooperative process, medication information management is a complex domain for development activities. We studied medication activities and related information management in a regional project in order to produce a shared broad ...
Hussain Sajjad S INSERM, U1142, LIMICS, AP-HP, F-75006, Paris, - - 2014
Use of medical terminologies and mappings across them are considered to be crucial pre-requisites for achieving interoperable eHealth applications. Built upon the outcomes of several research projects, we introduce a framework for evaluating and utilizing terminology mappings that offers a platform for i) performing various mappings strategies, ii) representing terminology ...
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