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Huo Xiang X Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Acute Infectious Disease, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, - - 2014
Influenza remains one of the most important causes of respiratory infection despite the widespread availability of vaccines. Anti-influenza viral agents such as neuraminidase inhibitors are generally efficacious in alleviating the symptoms if they are administered within 2 days of the illness onset. However, few studies have examined the situation of ...
Carlson Josh J JJ Pharmaceutical Outcomes Research and Policy Program, University of Washington, Box 357630, Seattle, WA, 98195-7630, USA, - - 2014
Our objective was to identify and characterize publicly available cases and related trends for performance-based risk-sharing arrangements (PBRSAs). We performed a review of PBRSAs over the past 20 years (1993-2013) using available databases and reports from colleagues and healthcare experts. These were categorized according to a previously published taxonomy of scheme ...
Pankhurst T T Department of Nephrology, Queen Elizabeth Hospital Birmingham, Birmingham, - - 2014
Background/Aims: Acute kidney injury (AKI) following admission to hospital is associated with increased mortality, morbidity and length of stay. Factors that predispose patients to AKI frequently co-exist. The precise description of their representation in unselected admissions could help define mechanistic inter-relationships and optimise risk stratification strategies. Our aim was therefore ...
Falconer Nazanin N Nazanin Falconer, B.Pharm., PGCert, is Medication Safety Pharmacist; Sanjoy Nand, B.Pharm., M.Pharm., is Pharmacy Service Manager; Doreen Liow, B.Pharm., M.B.A., PGDip, is Clinical Pharmacy Manager; and Mary Seddon, M.B.Ch.B., is Clinical Director, Centre for Quality Improvement, Middlemore Hospital, Auckland, New Zealand. Aaron Jackson, B.Pharm., is Medication Management Manager, Orion Health, - - 2014
A software-based tool to help prioritize inpatients for adverse drug event (ADE) prevention initiatives is described. The clinical pharmacy department of a New Zealand hospital developed the Assessment of Risk Tool (ART), an application for monitoring prespecified clinical "flags" (some derived from the Institute for Healthcare Improvement's ADE trigger tool) ...
Gonzales Kelly K From the University of Nebraska Medical Center College of Nursing, Nebraska Medical Center, Omaha, - - 2014
To examine the relationship between risk propensity and safe medication administration, while also providing additional evidence of validity and reliability on the Safe Administration of Medication (SAM) Scale. A convenience sample of nursing students from a private Midwest university in the United States was invited to participate in the study. ...
Hall Joseph L - - 2014
The success of telehealth could be undermined if serious privacy and security risks are not addressed. For example, sensors that are located in a patient's home or that interface with the patient's body to detect safety issues or medical emergencies may inadvertently transmit sensitive information about household activities. Similarly, routine ...
Collins C Scott CS Division of General Internal Medicine, Mayo Clinic, Rochester, MN. - - 2014
The number, age, and medical complexity of patients undergoing elective noncardiac surgery is rising worldwide. Internists, family physicians, and midlevel providers asked to perform preoperative medical evaluations. However, lack of consensus has led to wide variation in practice in what is included and addressed in these evaluations, and the efficacy ...
Nelson Lewis S LS Department of Emergency Medicine, New York University School of Medicine, New York City Poison Control Center, 455 First Avenue, Room 123, New York, NY, 10016, USA, - - 2014
The decision to approve a drug for clinical use is based on an understanding of its benefits versus the risks. Although efficacy is generally understood at the time of submission to the FDA for approval, the risks are more difficult to assess. Both PubMed (from 2000 to 2012) and the ...
Cooper William O WO Departments of - - 2014
OBJECTIVES:Recent data showing possible increased risk for suicidal behavior among children and adolescents treated with selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) antidepressants have created significant concern among patients, families, and providers, including concerns about the risk of individual antidepressants. This study was designed to compare the ...
Hegarty Francis J - - 2014
Medical device interoperability has been identified as a key way of decreasing healthcare costs while improving patient care. 1 This has led to a shift toward placing more medical devices onto information technology (IT) networks. However, placing medical devices onto an IT network may lead to additional risks to safety, ...
Girela E E Department of Legal and Forensic Medicine, Faculty of Medicine, University of Córdoba, Avenida Menéndez Pidal s/n, 14071 Córdoba, - - 2014
We have studied the use of coercive medical measures (forced medication, isolation, and mechanical restraint) in mentally ill inmates within two secure psychiatric hospitals (SPH) and three regular prisons (RP) in Spain. Variables related to adopted coercive measures were analyzed, such as type of measure, causes of indication, opinion of ...
Makowsky Mark J MJ Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, - - 2014
Pharmacists working in primary care clinics are well positioned to help optimize medication management of community-dwelling patients who are at high risk of experiencing medication-related problems. However, it is often difficult to identify these patients. Our objective was to test the feasibility of a self-administered patient survey, to facilitate identification ...
Bozzato Silvia - - 2013
Acutely ill medical patients may be at increased risk of venous thromboembolism, both during hospitalization and after discharge. International guidelines recommend thromboprophylaxis for high-risk medical patients with low bleeding risk for a maximum of 14 days. There are two approaches to identify the high-risk patient: adhering to the inclusion criteria ...
Nelson D Alan - - 2013
No evidence-based mechanism currently exists to inform U.S. Army clinicians of soldiers at risk of being found "Medically Not Ready" for combat duty. Historically, musculoskeletal conditions represent high-frequency medical problems among Army soldiers. We explored the feasibility of using centrally archived medical and administrative data on Army soldiers in the ...
Lee Michael J - - 2013
The possibility and likelihood of a post-operative medical complication after spine surgery undoubtedly play a major role in the decision making of the surgeon and patient alike. While prior study has determined Relative Risk and Odds Ratio values to quantify risk factors, these values may be difficult to translate to ...
Harmon John P - - 2013
Atrial fibrillation and cardiovascular death are increased in end-stage renal disease (ESRD) patients compared to the general population. The effect of anticoagulant and antiplatelet medications for these indications in ESRD is unclear. However, both classes of medications have been used for the preservation of vascular access. This review explores the ...
Newcomer John W - - 2013
The purpose of this project was to provide evidence-based guidance concerning when and how it is appropriate to undertake elective changes in antipsychotic medications in order to reduce adverse effects, with a focus on those adverse effects associated with increased long-term health risks. This project extends the results of the ...
Thongbai Thirada T Department of Medicine, Bangkok Metropolitan Administration General Hospital, Bangkok, Thailand. - - 2013
Aspirin is a widely used medication for primary and secondary prevention of cardiovascular and cerebrovascular events. The gastrointestinal risks of aspirin are well known, but the frequency of gastroduodenal mucosal injuries in aspirin users in Thailand is currently unknown. The present study was performed to investigate the prevalence of gastroduodenal ...
Norris Beverley - - 2013
A multi-disciplinary approach to designing safer healthcare was utilised to investigate risks in the bed-space in elective surgical wards. The Designing Out Medical Error (DOME) project brought together clinicians, designers, psychologists, human factors and business expertise to develop solutions for the highest risk healthcare processes. System mapping and risk assessment ...
Okada Yasushi - - 2014
Since transient ischemic attack (TIA) is regarded as a medical emergency with high risk for early stroke recurrence, the underlying mechanisms should be immediately clarified to conclude a definitive diagnosis and provide early treatment. Early risk stratification using ABCD(2) scores can predict the risk of ischemic stroke occurring after TIA. ...
Harrison Donald C - - 2013
The 20-year activities of a medical supervisory panel appointed under the terms of a settlement agreement of the Bowling v. Pfizer class action suit involving the Björk-Shiley convexo-concave (BSCC) heart valve are detailed. Of approximately 86,000 valves implanted, catastrophic failure of the valve was reported in 663 patients from 1978 ...
Davidson Jaime A JA Division of Endocrinology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd. K5.246, Dallas, TX, 75235-8857, USA, - - 2013
Type 2 diabetes is associated with a high prevalence of comorbidities resulting from hypertension, dyslipidemia, and hyperglycemia. Inadequate management of these risk factors will eventually result in detrimental health consequences. Thus, the effect of a drug on factors such as weight, cardiovascular (CV) risk factors, and adherence is important to ...
Gillette Chris - - 2013
The objectives of this study were to: (1) describe the extent to which general pediatric providers discuss risks associated with asthma control medications with families, and (2) examine factors that are associated with risk discussions. This study was a cross-sectional secondary analysis of audio taped medical visits involving 35 pediatric ...
Kelly Aaron S - - 2013
Severe obesity afflicts between 4% and 6% of all youth in the United States, and the prevalence is increasing. Despite the serious immediate and long-term cardiovascular, metabolic, and other health consequences of severe pediatric obesity, current treatments are limited in effectiveness and lack widespread availability. Lifestyle modification/behavior-based treatment interventions in ...
Adachi Kenji - - 2013
Background. Pre-travel health consultations help international travelers manage travel-related illness risks through education, vaccination, and medication. This study evaluated costs and benefits of that portion of the health consultation associated with malaria prevention provided to U.S. travelers bound for West Africa. Methods. The estimated change in disease risk and associated costs and ...
Porter Emily B - - 2013
Figure skating continues to increase in popularity as both a recreational and competitive sport. Skaters continue to "push the envelope" in perfecting more technically difficult skills. With their strenuous training programs, skaters are at risk from chronic overuse injuries, which tend to plague singles skaters more often than acute injuries. ...
Thomas Maria - - 2013
An effective intervention to decrease medication errors related to high-risk, high-alert medications is to implement double checks and second verification using the five rights of medication administration. To evaluate the effectiveness and use of the Personalized Bar-Code Identification card in verifying high-risk, high-alert medications, the High-Risk, High-Alert Medication Verification Audit ...
Dupnik Kathryn Margaret KM Division of Infectious Diseases and Center for Global Health, Weill Cornell Medical College, New York, NY, - - 2013
The objective was to characterise and identify potential risk factors for intolerance to multi-drug leprosy therapy (MDT) which prompted a medication change in a leprosy referral centre in northeastern Brazil. A retrospective chart review of leprosy patients treated at a state referral centre for leprosy in Natal, Rio Grande do ...
Zipursky Robert B - - 2013
The large majority of individuals with a first episode of schizophrenia will experience a remission of symptoms within their first year of treatment. It is not clear how long treatment with antipsychotic medications should be continued in this situation. The possibility that a percentage of patients may not require ongoing ...
Ontaneda Daniel - - 2013
The growing number of disease-modifying medications approved for multiple sclerosis (MS) treatment is a significant step forward and provides new options for our patients. These medications, however, have differing efficacy and risk profiles. Although accurate predictors of efficacy are not available, treatment choices can be guided by patient-specific risk stratification. ...
Cummings Doyle M - - 2013
The extent to which low medication adherence in hypertensive individuals contributes to disparities in stroke and transient ischemic attack (TIA) risk is poorly understood. Investigators examined the relationship between self-reported medication adherence and blood pressure (BP) control (<140/90 mm Hg), Framingham Stroke Risk Score, and physician-adjudicated stroke/TIA incidence in treated hypertensive ...
Weng M-C - - 2013
Summary BACKGROUND: Older patients with chronic diseases often take multiple prescription drugs, increasing their risk of adverse health events. However, polypharmacy remains ill-defined. To investigate the impact of number of drugs prescribed on potentially inappropriate medication (PIM) and the associated risk factors in older outpatients with chronic diseases. Retrospective cross-sectional ...
Ojeleye Oluwagbemileke - - 2013
Electronic Patient Medication Record (ePMR) systems have important safety features embedded to alert users about potential clinical hazards and errors. To date, there is no synthesis of evidence about the effectiveness of these safety features and alerts at the point of pharmacy order entry. This review aims to systematically explore ...
Schwarz Eleanor Bimla - - 2013
Medications that may increase risk of birth defects if used during pregnancy or immediately preconception are dispensed to approximately half of female Veterans who fill prescriptions at a VA pharmacy. To assess receipt of counseling about risk of medication-induced birth defects among female Veterans of reproductive age and to examine ...
Messano G A - - 2013
Malpractice is the responsible for the greatest number of legal claims. At the present time, legal actions against physicians in Italy are 15,000 per year, and a stunning increase about costs to refund patients injured by therapeutic and diagnostic errors is expected. The method for the medical prevention is "Risk ...
Cranford James A - - 2013
The purpose of this study was to identify subgroups of adolescents based on their past 12 months use of tobacco, alcohol, marijuana, illicit drugs, and nonmedical use and excessive medical use of prescription medications. A cross-sectional Web-based survey of adolescents from two middle and high school districts in Southeastern Michigan ...
Woods Scott W - - 2013
Antipsychotic medication use rates have generally been rising among youth with psychiatric disorders, but little is known about use rates of antipsychotics or other psychotropic medications in patients at high risk for psychosis. Baseline psychotropic medication use rates were compared in two research cohorts of patients at high risk for ...
Bailey Genie L - - 2013
Most patients with opioid addiction do not receive medication at the time of discharge from brief inpatient detoxification programs despite the high risk of relapse and the availability of three FDA-approved medications. We surveyed 164 inpatient opioid detoxification patients to assess desire for pharmacotherapy following detoxification program discharge. Participants were ...
Teunissen Rick - - 2013
The clinical relevance of and risk factors associated with errors related to medication administration time were studied. In this explorative study, 66 medication administration rounds were studied on two wards (surgery and neurology) of a hospital. Data on medication errors were collected using the blister collection method. The emptied packaging ...
Liao P-J - - 2013
The aim of this study was to explore the factors associated with the occurrence, subsequent prognoses and need for additional medications following cutaneous adverse drug reactions (ADRs) among inpatients. This is a case-control study, nested in a large cohort study of 473,446 inpatients hospitalised from 2005 to 2008, examined cutaneous ...
Claes Neree - - 2013
BACKGROUND: Cardiovascular disease is a major cause of mortality and morbidity and its prevalence is set to increase. While the benefits of medical and lifestyle interventions are established, the effectiveness of interventions which seek to improve the way preventive care is delivered in general practice is less so. The aim ...
Caprio Fan Z - - 2013
Intracranial atherosclerotic disease (ICAD) is one of the most common causes of ischemic stroke worldwide and is associated with a high risk of recurrent stroke despite aggressive therapy. ICAD may lead to cerebral ischemia through a variety of mechanisms, the interactions of which are largely unknown. The use of endovascular ...
Goldman Dana - - 2013
Medical expenses are an increasingly important contributor to household financial risk. We examine the effect of medical expenditure risk on the willingness of Medicare beneficiaries to hold risky assets. Using a discrete factor maximum likelihood method to address the endogeneity of insurance choices, we find that having a moderately protective ...
Murphy Mary P - - 2013
PURPOSE: Falls are a challenge for rehabilitation nurses, facilities, families, and individuals. Studies related to the causes of falls and potential strategies for risk management have been conducted across disability groups and with the elderly. Still, a focus on individuals with traumatic brain injuries (TBI), specifically, has been limited. This ...
Merkel Reinhard R Faculty of Law, University of Hamburg, Rothenbaumchaussee 33, Hamburg 20148, Germany. - - 2013
Non-therapeutic circumcision violates boys' right to bodily integrity as well as to self-determination. There is neither any verifiable medical advantage connected with the intervention nor is it painless nor without significant risks. Possible negative consequences for the psychosexual development of circumcised boys (due to substantial loss of highly erogenous tissue) ...
Hübner Nils-Olaf - - 2013
BACKGROUND: The use of examination gloves is part of the standard precautions to prevent medical staff from transmission of infectious agents between patients. Gloves also protect the staff from infectious agents originating from patients. Adequate protection, however, depends on intact gloves. The risk of perforation of examination gloves is thought ...
Brett Hauber A - - 2013
Decisions regarding the development, regulation, sale, and utilization of pharmaceutical and medical interventions require an evaluation of the balance between benefits and risks. Such evaluations are subject to two fundamental challenges-measuring the clinical effectiveness and harms associated with the treatment, and determining the relative importance of these different types of ...
Roberts Charles G - - 2013
Biofilms are communities of microorganisms within extracellular polymeric material attached to surfaces. Within a biofilm, cells have some protection from drying and other stress factors in their environment, including antimicrobial agents. In this article, the challenges to medical device reprocessing posed by biofilms are addressed. Biofilm formation on reusable medical ...
Al-Turkistani Hatim K - - 2013
Discharging patients against medical advice is a problem of every age-group. However, because of their physiological vulnerability, the risk for the neonatal population is greater when discharged against medical advice (DAMA). This article is a study of the prevalence of the problem, the possible causes and/or risk factors. A retrospective ...
Kupensky Diane T - - 2013
Depression is on the rise, and as a result, there is an increased use of psychotropic medications. Also, nonreversible anticoagulants have entered the market and are increasing in use. In combination, these developments have created new risk factors for trauma patients. Our study examined the occurrence of trauma patients who ...
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