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Weise Martina M Bundesinstitut fuer Arzneimittel und Medizinprodukte (BfArM), Bonn, Germany; - - 2014
Despite the establishment of a specific approval pathway, the issuance of detailed scientific guidelines for the development of similar biological medicinal products (so-called 'biosimilars') and the approval of several biosimilars in the European Union, acceptance of biosimilars in the medical community continues to be low. This is especially true in ...
Kattimani Shivanand S Department of Psychaitry, JIPMER, Puducherry, 605006, - - 2014
There is a dearth of studies exploring spiritual attitudes of medical students from developing countries and its relationship to anger. This study was conducted to assess spiritual attitudes and their relationship with anger in a set of medical students in southern India. In this cross-sectional observational study, medical students who ...
Kudo Chieko C Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, Okayama, 700-8525, - - 2014
It has been revealed that atherosclerosis and periodontal disease may have a common mechanism of "chronic inflammation". Several reports have indicated that periodontal infection is related to atherosclerosis, but none have yet reported such an investigation through the cooperation of local clinics. This study was performed in local Japanese clinics ...
Frith Lucy L Department of Health Service Research, University of Liverpool, Block B, Waterhouse Building, Brownlow Street, Liverpool, L69 3GL, UK. Electronic address: - - 2014
The regulation of assisted reproductive technologies is a contested area. Some jurisdictions, such as the UK and a number of Australian states, have comprehensive regulation of most aspects of assisted reproductive technologies; others, such as the USA, have taken a more piecemeal approach and rely on professional guidelines and the ...
Adisetiyo Vitria V From the Center for Biomedical Imaging (V.A., J.H.J., A.T., R.L.D., J.A.H.), Department of Radiology and Radiological Science (V.A., J.H.J., A.T., R.L.D., J.A.H.), Department of Psychiatry and Behavioral Sciences (K.M.G.), and Department of Neurosciences (J.A.H.), Medical University of South Carolina, 68 President St, Bioengineering Building, 2nd Floor, Charleston, SC 29425; Center for Biomedical Imaging, Department of Radiology (E.F., F.X.C.), Child Study Center, Department of Child and Adolescent Psychiatry (A.D.M., F.X.C.), and Department of Physiology and Neuroscience (F.X.C.), New York University School of Medicine, New York, NY; and Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY - - 2014
Purpose To comprehensively assess brain iron levels in typically developing control subjects and patients with attention deficit hyperactivity disorder (ADHD) when psychostimulant medication history is accounted for. Materials and Methods This prospective study was approved by the institutional review board, and informed consent was obtained. Brain iron was indexed noninvasively ...
Lewis Drew D DD From the Department of Osteopathic Manual Medicine (Dr Lewis), the Department of Academic Affairs (Dr Johnson), and the Department of Physiology and Pharmacology (Dr Finnerty) at Des Moines University in Iowa - - 2014
Osteopathic manual medicine (OMM) encompasses hands-on diagnosis and treatment as part of patient care. The area of osteopathic principles and practice (OPP) is considered a core competency for students and practitioners of this medical tradition. The Comprehensive Osteopathic Medical Licensing Examination-USA (COMLEX-USA) is a useful tool for assessing candidates' competency. ...
Fried Moshe M Goldschleger Eye Research Institute, Tel Aviv University, Tel Hashomer, - - 2014
Oculomotor behavior and parameters are known to be affected by the allocation of attention and could potentially be used to investigate attention disorders. We explored the oculomotor markers of Attention-deficit/hyperactivity disorder (ADHD) that are involuntary and quantitative and that could be used to reveal the core-affected mechanisms, as well as ...
Grazier Michael R MR University of California San Francisco-Fresno, CA, - - 2014
To report a case of life-threatening cinchonism from illicit purchase of chloroquine and survey local ethnic markets to determine what medications are sold without a prescription. A 44-year-old Hmong woman presented with abdominal pain and vomiting 30 minutes after ingesting 20 presumed acetaminophen pills in a self-harm gesture. Initial vital ...
Meirowitz Natalie N Hofstra North Shore-LIJ School of Medicine, New Hyde Park, - - 2014
Our objective was to evaluate an obstetric triage acuity tool that we developed and implemented in January 2013. A four-level triage acuity tool, Level 1 (most acute) to Level 4 (least acute), was developed to prioritize patients presenting for urgent care to the obstetric triage unit. Acuity scores, assigned by ...
Yew Haur Sen HS Mackay Base Hospital, Queensland, - - 2014
We retrospectively examined medical records of 87 patients with HACEK bacterbaemia to determine whether endocarditis was present as defined by the Duke criteria. The overall positive predictive value (PPV) of HACEK bacteraemia for endocarditis was 60%. The PPV varied with different HACEK species from 0% (Eikenella corrodens) to 100% (Aggregatibacter ...
Martínez-Quintana Efrén E Cardiology Department, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, - - 2014
There is increasing controversy about the influence of serum paraoxonase type 1 and cytochrome CYP2C19 in the conversion of clopidogrel to its pharmaceutically active metabolite. The effect of concomitant medication with the proton pump inhibitor omeprazole has been also subject of intense scrutiny.
Fukushima Hidetada H Department of Emergency and Critical Care Medicine, Nara Medical University, Kashihara, Nara, - - 2014
Current guidelines for cardiopulmonary resuscitation (CPR) emphasise that emergency medical service (EMS) dispatchers should identify sudden cardiac arrest (CA) with abnormal breathing and assist lay rescuers performing CPR. However, lay rescuers description of abnormal breathing may be inconsistent, and it is unclear how EMS dispatchers provide instruction for CPR based ...
Krupa Lukasz Zbigniew LZ Department of Gastroenterology, James Paget University Hospital, Great Yarmouth, - - 2014
The introduction of proton pump inhibitors (PPIs) in the late 1980s optimised the medical treatment of acid-related disorders. They are potent medications and have a good safety profile. However, long-term therapy with PPIs may carry undesired side effects, one of which is hypomagnesaemia. This entity is likely to be under-reported. ...
Davis James J John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, - - 2014
The primary objective was to assess associations between increases in glycated hemoglobin (HbA1c) levels and medication adjustments among patients with diabetes. A secondary objective was to measure the effect of adjustments on subsequent HbA1c levels. A retrospective analysis of administrative data from a large health insurer in Hawaii of 7654 ...
Naylor A R - - 2013
The highest risk period for suffering a stroke after a transient ischaemic attack (TIA) or temporary monocular blindness (TMB) is the first 14 days and this is the recommended threshold for performing carotid endarterectomy (CEA). However, evidence suggests that TMB patients face significant delays in starting medical therapy and undergoing ...
Crowley Matthew J MJ Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC; Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Duke University, Durham, NC. Electronic address: - - 2014
Group medical clinics may improve diabetes and hypertension control, but data about dyslipidemia are limited. We examined the impact of group medical clinics on lipids among patients with uncontrolled diabetes and hypertension. Prespecified secondary analysis of 239 veterans randomized to group medical clinics or usual care. Lipids were assessed at ...
Oranje Bob - - 2013
Background: Sensory gating deficits are among the core features of schizophrenia. Recently, we reported significantly increased sensorimotor gating following additional administration of single dosages of clonidine to the treatment of stably medicated patients with schizophrenia who, in spite of their medication, showed gating deficits. In the current study, we investigated ...
Taha Firas A - - 2013
Antiepileptic medication interactions can complicate the management of epilepsy, by either increasing or reducing the effective serum concentrations thereby causing adverse effects or loss of seizure control. A 14-year-old girl with well-controlled juvenile absence epilepsy lost control of her seizures acutely following the administration of carbapenem for pneumonia. Serum valproate ...
Freund Jeff - - 2013
Our primary aim was to characterize the level of medication use across age-groups by examining electronic medical record data for a large number of patients receiving care in primary care clinics. A secondary aim was to identify factors associated with higher levels of medication use or polypharmacy. We conducted a ...
Mghamba Frida William - - 2013
BACKGROUND: Adherence to antiretroviral drugs in the treatment of paediatric HIV infection is complicated because of many factors including stigma and drug intake logistics. It is therefore important to identify children with non-adherence in order to intervene before they become at risk of developing treatment failure or drug resistance. The ...
Raman Gowri - - 2013
Adults with asymptomatic carotid artery stenosis are at increased risk for ipsilateral carotid territory ischemic stroke. To examine comparative evidence on management strategies for asymptomatic carotid stenosis and the incidence of ipsilateral stroke with medical therapy alone. MEDLINE, Cochrane Central Register of Controlled Trials, U.S. Food and Drug Administration documents, ...
Nonoda Yutaka - - 2013
AIM: To evaluate the long-term efficacy of gabapentin (GBP) and usefulness of measurement of the blood level for the observation of patients that have partial seizures. METHODS: Thirty patients (20 effective cases and 10 ineffective cases) treated with GBP for the localization related epilepsy had their peak blood levels of ...
Yin Dengke - - 2013
Tao-Hong-Si-Wu decoction (TSD) is a famous traditional Chinese medicine (TCM) and widely used for ischemic disease in China. TSD medicated serum was prepared after oral administration of TSD (1.6 g/kg) twice a day for 3 days in rats. TSD medicated serum induced human umbilical vein endothelial cells (HUVECs) proliferation, VEGF secretion, ...
Konishi Kimiko - - 2012
We report the case of a 74-year-old woman who presented with amnesia and positive serum anticholinergic activity (SAA), which disappeared after treatment with the cholinesterase inhibitor donepezil for 1 year. Her only other regular medications were topical glaucoma preparations. We suggest that mental stress, mild cognitive impairment and Alzheimer's disease ...
Nugent Michael E - - 2012
To deliver greater value, top payers and providers should: Measure the value they deliver to their business partners and customers, Create value through continuous performance improvement, Package and price value to optimize their margin, mission, and market share, Organize for value through new legal entities, employed medical groups, or both.
Hallin Magnus Lars Peter - - 2012
We report two patients with markedly elevated 24-h urine 5-hydroxyindoleacetic acid (5-HIAA) excretion due to over-the-counter (OTC) self-medication with 5-hydroxytryptophan (5-HTP). It is important to recognize that OTC medication may cause increased 'false-positive' 5-HIAA excretion to prevent undue patient anxiety and unnecessary further investigation for carcinoid disease. Discordance between chromogranin ...
Cousins David H DH National Patient Safety Agency, London, UK. - - 2012
A review of all medication incidents reported to the National Reporting and Learning System (NRLS) in England in Wales between 1 January 2005 and 31 December 2010 was undertaken. The 526,186 medication incident reports represented 9.68% of all patient safety incidents. Medication incidents from acute general hospitals (394,951) represented 75% ...
Liao Pei-Ju - - 2012
Background: The prediction of violence among psychiatric inpatients using biophysiological indicators is warranted for re-examinations longitudinally. This study aims to explore factors associated with the occurrence of violence and subsequent medical impacts in psychiatric inpatients. Methods: Inpatients diagnosed with either schizoaffective disorder or bipolar mania were admitted to acute wards ...
Herron Abigail J AJ St. Luke's Roosevelt Hospital Center, 324 W. 108th Street, #505, New York, NY 10025, USA. - - 2013
Noncompliance with medications may have major impacts on outcomes measured in research, potentially distorting the validity of controlled clinical trials. Riboflavin is frequently used in trials as a marker of adherence. It can be combined with study medication and is excreted in urine where it fluoresces under UV light. This ...
An Hoyoung - - 2012
High levels of stress and depression in medical students is raising concern. In this study, we sought to identify coping strategies and other factors influencing academic stress in medical students. We enrolled 157 students from the University of Ulsan College of Medicine, Korea, in November, 2010. We used the Medical ...
Thethi Indermohan - - 2012
Oral anticoagulation used to be synonymous with warfarin until the recent approval of oral direct thrombin inhibitors and factor Xa inhibitors in United States and other countries across the world. Thrombosis prevention and treatment continue to be the main objective and goal for surgical and medical patients. Regulatory agencies continue ...
Bahr Roald - - 2012
BackgroundThere seems to be a discrepancy between the available heat stress guidelines and the actual risk of heat-related illness among professional beach volleyball players competing under hot and humid conditions.ObjectiveTo monitor heat stress and record cases of heat-related medical forfeits on the Swatch FIVB Beach Volleyball World Tour.MethodsThe FIVB Heat ...
Dunlop Boadie W - - 2012
Posttraumatic stress disorder (PTSD) is a common condition for which existing treatments are ineffective for many patients. Recent discoveries in the neurobiology of learning and memory, along with expanding knowledge of how those systems are impacted by the biology of the stress response, have opened new arenas for potential medication ...
Chang Elaine - - 2012
OBJECTIVE The authors determined the prevalence of stress, depression, and burnout in medical students and the resources used by students in one school to alleviate psychological distress. METHODS A survey was administered to 526 students in the first 3 years of medical school (336 responders; response rate: 70%) at one ...
Farina Junior Jayme A - - 2012
Today it is known that severe burns can be accompanied by the phenomenon of vasoplegic syndrome (VS), which is manifested by persistent and diffuse vasodilation, hypotension and low vascular resistance, resulting in circulatory and respiratory failure. The decrease in systemic vascular resistance observed in VS is associated with excessive production ...
Park Jangho - - 2012
The purpose of the present study was 1) to identify factors that may influence academic stress in medical students and 2) to investigate the causal relationships among these variables with path analysis. One hundred sixty medical students participated in the present study. Psychological parameters were assessed with the Medical Stress ...
Lockington D - - 2012
Preservatives in ophthalmic preparations are known to cause ocular surface damage. Excipients can also contribute to oxidative stress in the compromised ocular surface. We evaluated commonly used topical glaucoma medications to ascertain pH levels and the intrinsic presence of free radicals. Samples of 27 topical glaucoma preparations were analysed for ...
- - 2012
Dynamic MRIs showing changes over time in 2 patients with progressive cerebellar tonsillar ectopia who have a disorder of brain overgrowth. See article by Mirzaa et al. in this issue.
Gadoud Amy - - 2012
Background:  All newly qualified doctors will look after patients in the last stages of life. Context:  This article is a review of the literature regarding medical students learning from hospice patients, focusing on practical concerns of relevance to those involved in organising or conducting medical student teaching. Innovation:  Medical students ...
Behrens-Muller Brie - - 2012
Objective. To define the extent of an outbreak of Achromobacter xylosoxidans bacteremia, determine the source of the outbreak, and implement control measures. Design. An outbreak investigation, including environmental and infection control assessment, and evaluation of hypotheses using the binomial distribution and case control studies. Setting. A 50-bed medical surgical unit in a hospital ...
Chu Eugene S - - 2012
BACKGROUND: While patients with anorexia nervosa have a high mortality rate, more are living into adulthood. Patients with severe malnutrition secondary to anorexia nervosa often require hospitalization for medical stabilization prior to treatment in eating disorders programs. METHODS: We developed the ACUTE Center at Denver Health Medical Center to medically ...
Pellegrino Edmund D - - 2012
What it means to be a medical professional has been defined by medical ethicists throughout history and remains a contemporary concern addressed by this paper. A medical professional is generally considered to be one who makes a public promise to fulfill the ethical obligations expressed in the Hippocratic Code. This ...
Rattinger Gail B - - 2012
Alzheimer's disease and related disorders (ADRD) are prevalent in older adults, increase the costs of chronic heart failure (CHF) management, and may be associated with undertreatment of cardiovascular disease. The purpose of our study was to determine the relationship between comorbid ADRD and CHF medication use and adherence among Medicare ...
Sarangarm Preeyaporn - - 2012
BACKGROUND Clinical teratology studies often rely on patient reports of medication use in pregnancy with or without other sources of information. Electronic medical records (EMRs), administrative databases, pharmacy dispensing records, drug registries, and patients' self-reports are all widely used sources of information to assess potential teratogenic effect of medications. The ...
Wortsman X - - 2012
Disorders of the scalp often result in severe cosmetic interference with quality of life, creating the need for optimal medical surveillance. We tested the latest generation of ultrasound machines in patients with scalp pathology and prepared a cross-sectional library encompassing a wide assortment of conditions. Normative data on the sonographic ...
Wichmann Dominic D University Medical Center Hamburg-Eppendorf, Germany. - - 2012
Autopsy is an important educational and quality-control tool in the intensive care unit (ICU), but rates of traditional medical autopsies have declined worldwide. "Virtual" autopsy involving only advanced radiographic techniques might provide an alternative approach to postmortem examinations. To assess the value of postmortem multidetector computed tomography as an alternative ...
Blinman Prunella L - - 2012
To determine current and projected supply, demand and shortfall of medical oncologists (MOs) and the Australian chemotherapy utilisation rate. A 2009 cross-sectional observational study of Australian adult medical oncology practice work patterns. Electronic or paper self-administered questionnaire. The 2009 and projected (2014) supply, demand and shortfall of full-time equivalent (FTE) MOs, and ...
McGrane S - - 2012
studies have shown that these medication can themselves lead to adverse patient outcomes. Interventions that facilitate a total dose reduction in analgesic and sedative medications e.g. the use of nurse controlled protocol guided sedation, the combination of spontaneous awakening and breathing trials, and the use of short acting medications, are ...
Marks Michael P - - 2012
The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke and Intracranial Stenosis (SAMMPRIS) trial, a randomized clinical trial comparing aggressive medical management to stenting with aggressive medical management for symptomatic intracranial stenosis, was prematurely halted when a high rate of periprocedural events was found in the stent arm. The ...
Assaad Basel - - 2012
BACKGROUND: Uncertainty exists regarding the management of antithrombotic medications in ischemic stroke and transient ischemic attack (TIA) patients around the time of colonoscopy. We sought to evaluate whether there was a difference in adverse events among patients who continued medications and those who had temporary discontinuation. METHODS: Using a hospital ...
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