The availability of cyclosporin A (CyA) administered as an enteric solid dispersion preparation of which the composition is CyA:HCO-60:HP-55 = 1:2:8 was evaluated in rabbits. The additives are surfactant (polyoxyethylated, 60 mumol, castor oil derivative, HCO-60) and enteric coating material (hydroxypropylmethyl cellulose phthalate, HP-55), which are generally used as pharmaceutical ...

All medical personnel use jargon when conversing about patients. Such jargon can be clarified by questions asked at the moment of discussion. The reader of a discharge summary, however, does not have the option of questioning the author if meanings are ambiguous and vague. Editing discharge summaries is an impossible ...

We prospectively measured the on-scene time, transport time, and IV line starting time for 97 patients receiving paramedic care in an urban region during an 18-month period. The overall success rate for IV line placement was 91%, and the average successful IV line starting time was 2.5 minutes. En route ...

Normal functional variations of the flexor digitorum superficialis were clinically determined by use of the standard and modified superficialis flexion tests in 50 normal subjects. Forty hands of 20 cadavers were dissected to correlate the anatomic variations with the clinical findings. A flexor digitorum superficialis-independent pattern was found 58% of ...

The bioavailability of phenytoin from ACC-9653 versus intravenously administered sodium phenytoin was determined using a crossover design for intravenous and intramuscular administration of ACC-9653 to healthy volunteers. Absolute bioavailability of phenytoin derived from ACC-9653 in each subject was calculated as the ratio of the phenytoin area under the plasma concentration ...

Fifteen stutterers and 15 nonstutterers read a 120-word passage five times in succession. From the stutterers' readings, sentences were selected for analysis that were produced fluently in the first and the fifth reading. The sentences surrounding the target utterance in the first reading, however, contained instances of stuttering although the ...

CS-622 is a prodrug type ACE inhibitor with a thiazepin ring. Its active form, CS-622 diacid, was slightly more potent than enalaprilat in inhibiting ACE isolated from rabbit lung. The inhibitory potency of CS-622 diacid on isolated rat aorta was 3 times that of enalaprilat. The inhibitory action of enalaprilat ...

Psychology of deaths due to acute medical emergencies is under-researched. Most studies till now have concentrated on extended-death situations like malignancy. This open pilot study of twenty five patients examines the psychological state of patients during a life threatening acute medical illness (Group A, ten patients) and of those who ...

The effects of acute administration of reduced haloperidol (RHAL) on homovanillic acid (HVA) in the caudate and prefrontal cortex were examined in rats. Haloperidol (HAL) was used as a reference compound. Concentrations of HVA and HAL were measured by HPLC/ECD. The maximal HVA response time was 3 hr after the ...

In the present investigation, we studied and measured the phenomenon of tetanic fade and peak tetanic tension depression in the rat diaphragm preparation in the presence of a blocking concentration of atracurium (e.g., 10 mumol.l-1). Atracurium (10 mumol.l-1) produced a pronounced tetanic fade (i.e., 47-69% reduction of total sustained tetanic ...

In a randomized intraindividual cross-over study 8 healthy volunteers received subcutaneously 1500 IU, 2000 IU and 25,00 IU, respectively, of low molecular weight heparin (LMWH) in 24-h intervals, as well as 12-hourly 3 applications of 5000 IU of unfractionated heparin. The wash-out phases between the different medications lasted 7 days ...

The pharmacological effects of N-[4-(2-bromoethylmethylamino)-2-butynyl]-2-pyrrolidone (BR 401) were compared in the mouse with those of N-[4-(2-chloroethylmethylamino)-2-butynl]-2-pyrrolidone (BM 123) and oxotremorine. BR 401 was more toxic than oxotremorine and BM 123 when administered i.v. (LD50, 0.7 mumol kg-1), but less toxic than oxotremorine when given i.p. (LD50, 39 mumol kg-1). Atropine ...

Psychiatric morbidity in the patients attending the medical outpatient clinic of a Urge general hospital was studied using a short 5 - item version of the General Health Questionnaire (GHQ). The overall percentage of high scorers, (score 2 and above) was found to be 51% (45% for Males and 59% ...

The fluorescence of purified biliproteins (phycocyanin 645, phycocyanin 612, and phycoerythrin 545) from three cryptomonads, Chroomonas species, Hemiselmis virescens, and Rhodomonas lens, and C-phycocyanin from Anacystis nidulans has been time resolved in the picosecond region with a streak camera system having less than or equal to 2-ps jitter. The fluorescence ...

In 4 separate experiments involving 133 ewes the timing of the onset of the LH discharge relative to the onset of oestrus was compared in prolific Booroola Merinos and in other Merinos of low ('C' and 'O' genotypes) and medium ('T' genotype) prolificacy. Despite different average ovulation rates of 3.05, ...

A program for calculation of constant-infusion vasoactive medications on a hand-held programmable calculator was evaluated in terms of accuracy and time saved v conventional means of calculation. All groups, with the exception of the pharmacists, showed a statistically significant improvement in accuracy and time saved when using the programmable calculator. ...

With his back to the academically poorly oriented times of medieval Europe, Copernicus, the medical man, led the world into a concept of infinite space. His revolutionary concepts of astrophysics formed a buttress for the efforts of his successors. He looked to the stars, but he also had time to ...

A commercially available microwave oven modified for use at medication stations throughout hospitals allows timely thawing of frozen parenteral solutions. The inherent problems of safety and uniform heating have been overcome, thus making possible the preparation, storage, and distribution of admixtures on a regional basis and ensuring the integrity of ...

Ovulation time of gilts was controlled by oral treatment with altrenogest (17-allyl-hydroxyestra-4,9,11-trien-3-one) followed by gonadotropic hormone injections. Gilts were laparotomized 42 to 44 h after injection of human chorionic gonadotropin. Spermatozoa were surgically placed into ligated oviducts of gilts after one of the following semen treatments: frozen and thawed in ...

Li2CO3 alone was administered to a 21-year-old female, who was in a manic state. As a consequence, lactation occurred on about the 50th day after Li2CO3 administration started, and the volume of lactation changed in parallel with the serum Li2CO3 level. The basal plasma PRL concentration and the responses to ...

The effect of repetitive administration of pilocarpine nitrate on the salivary volume and salivary IgA concentration was studied in the NIH white hamster. One and one-half to three-fold increases in salivary volume, coupled with decreases of 1/3 to 2/3 in IgA concentration, occurred as the frequency of administration of pilocarpine ...

The cavum septi pellucidi and cavum vergae are midline developmental cavities in the brain. They usually communicate and obliterate from posterior to anterior, the posterior cavum vergae obliterating first and then usually the anterior cavum septi pellucidi. A cavum vergae without a cavum septi pellucidi would thus be unexpected; however, ...

One hundred and three Alaskan gray wolves and 12 wolverines were immobilized in the Nelchina and upper Susitna River Basins of southcentral Alaska between March 1977 and May 1981. Sixty-five wolves were immobilized with a mixture of phencyclidine HCl and promazine HCl (PP/HCl); 38 wolves were immobilized with etorphine HCl ...

Eighty unpremedicated patients received thiopentone and halothane, propanidid and fentanyl, diprivan (ICI 35 868) alone, or diprivan and fentanyl, each supplementing 66% nitrous oxide in oxygen. Diprivan alone, or in combination with fentanyl, resulted in a more rapid awakening than thiopentone and halothane, and significantly shorter recovery times than both ...

In vitro measurements have proved that the polymerization time of n-butylcyanoacrylate (Histoacryl) can be delayed markedly and controlled by adding an oily radiopaque material. Our animal experiments have shown that a mixture of Histoacryl and Lipiodol ultrafluid at a 1:3 ratio provided an optimal embolization material with good flow properties, ...

In 1865/66 E. Haeckel for the first time suggested an evolutionary sequence in order to explain the origin of the first living cell. Haeckel's concept is compared with modern theories of the origin of life. It is evident that Haeckel has not as yet received the credit that he deserves ...

MMPI profiles of 10 psychiatric PG's have been compared with 10 medical PG's. The findings are discussed statistically and otherwise. Both the groups fall within the range of normal. Some interesting findings are not unexpected, if a larger section of population could be studied preferably over a span of few ...

A prospective randomized trial was carried out on 207 patients undergoing laparotomy using three different vertical abdominal incisions--midline, 'medial' paramedian incision and 'lateral' paramedian incision. The lateral paramedian incision is slightly more time-consuming to perform than the other two incisions but there is a statistically greater incidence of incisional hernia ...

We present a detailed investigation of the use of an extrapolation technique to decrease running times of sedimentation equilibrium experiments. If concentration profiles are available at time delta tau, 2delta tau, 3delta tau,...., cn(r) = c(r, n delta tau), then the Aitken transformation replaces the cn(r) + ĉn(r) = [cn ...

The start-up time is the delay between starting an infusion pump and the delivery of fluid at the set flow rate. Mechanical slack in syringe pumps can lead to start-up delays of an hour or more at low-flow rates. During this period no medication is delivered to the patient. The ...

AIM: To examine the delegation of medication administration, including the frequency of delegation, whether delegation was to a care worker or a registered nurse (RN) and whether care workers were directly supervised when administering medication. METHOD: Administration of 1313 medication doses was observed on two inpatient psychiatric wards for older ...

A suppository is a medicated solid formulation prepared for insertion into the rectum to dissolve at body temperature (Moppet and Parker, 1999). The administration of a suppository requires skill and competence on behalf of the practitioner, as well as compliance with the NMC (2004a) guidelines on the administration of medicines ...

This article examines the literature on non-medical prescribing to establish its impact on UK healthcare. It discusses how better access to medication through non-medical prescribing can improve patient safety and patient-centred care, and how nurse prescribing can help ensure quality of care in the NHS during the current financial crisis.

Article from the 1917 August 1 edition of the Los Angeles Times reports that teacher Clara G. DuBois is under medical care at California Hospital.

Article from the 1907 December 31 reports that Clarence Darrow is under medical care at California Hospital.