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Misak Cheryl J - - 2014
Efforts to answer the question of whether or when physicians may unilaterally refuse to provide treatments they deem medically futile, but that are nonetheless demanded by patients or their surrogates, have been characterized as intractable failures. We propose a new look at this old problem and suggest reframing the debate ...
Clark Bobby L BL Bobby L. Clark (bobby.clark@walgreens.com) is senior director of outcomes and health services research at Walgreens, in Deerfield, - - 2014
Section 340B of the Public Health Service Act provides qualified organizations serving vulnerable populations with deep discounts for some outpatient medications. A 2010 regulatory change widely expanded the 340B program's reach, allowing these organizations to contract with retail pharmacies to dispense medications for eligible patients. Little is known about which medications ...
May Lindsay J LJ From the *Division of Pediatric Cardiology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA; †Department of Pediatrics; ‡Division of Pediatric Neurology, Department of Pediatrics, Alberta's Children Hospital; §Alberta Children's Hospital Research Institute, Calgary, Alberta, Canada; and ‚ą•Division of Pediatric Cardiology, Department of Pediatrics, Alberta's Children Hospital, Calgary, Alberta, - - 2014
Migraine headache is common in pediatrics and is frequently assessed in emergency departments. Altered cardiac conduction, including prolongation of the QTc interval on electrocardiogram, has been observed in adults during migraine headache and resolves interictally. Prolonged QTc is associated with life-threatening arrhythmia, and many acute and prophylactic therapies for migraine ...
McGowan Vanessa V Department of Physical Medicine & Rehabilitation (Drs McGowan and Hoffman), University of California Davis Medical - - 2014
To examine the medical care at a highly competitive 161-km mountain ultramarathon. Encounter forms from the 2010 through 2013 Western States Endurance Run were analyzed for trends in consultation and use of intravenous fluids. A total of 63 consultations (8.2% of starters) were documented in 2012 and 2013, of which ...
Leung Ann N AN Professor of Radiology, Stanford University Medical Center, Stanford, - - 2014
Professionalism has been described as the "basis of medicine's contract with society." This article reviews the foundational principles of medical professionalism and, more specifically, defines the nature and scope of radiologists' responsibilities to patients. In the face of ongoing changes in the environment of medical practice, maintenance of professionalism is ...
Michalowsky Bernhard B German Centre for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, - - 2014
Background: Results of cost-of-illness studies in dementia have shown a considerable divergence in costs of medication for persons with dementia. However, detailed economic analyses of medication costs for community dwelling persons with dementia are currently still missing, especially on the basis of primary data. Objective: To determine medication cost, cost ...
Emeto Theophilus I - - 2014
Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Most AAAs are asymptomatic and screening programs have been introduced to identify AAAs at an early stage in some countries. There is currently no accepted therapy for early stage or small AAAs, which are frequently identified by ...
Wood Kelly E - - 2014
The objective of this study was to identify high-yield screening risk factors for detecting maternal non-medical drug use during pregnancy. A four year retrospective analysis was conducted at an academic medical center. Detailed chart review of both the newborn and mother's medical record was performed on all cases for which ...
Voltaggio Lysandra L Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland, - - 2014
Medication injury in the gastrointestinal tract (GIT) is a rapidly evolving topic. Increasing endoscopy together with an ageing population, polypharmacy, and a burgeoning drug industry offer heightened opportunities to observe the unintended side effects of therapeutic ingestants. In this review, we emphasise the most commonly encountered medication injuries involving the ...
Taler Sandra J SJ Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA, - - 2014
While there are strong trial data to guide the selection of initial hypertension treatment choice and limited data to support second agent choice, beyond the first two agents, subsequent steps are empiric. As medications are added, the resulting polypharmacy may be complex, inefficient and poorly tolerated, resulting in low treatment ...
Liu Lingyun L Department of Chemical and Biomolecular Engineering, University of Akron, Akron, OH, - - 2014
Antifouling polymers have been proven to be vital to many biomedical applications such as medical implants, drug delivery, and biosensing. This review covers the major development of antifouling polymers in the last 2 decades, including the material chemistry, structural factors important to antifouling properties, and how to challenge or evaluate ...
Weng Geng G School of Pharmaceutical Science, Peking University, Beijing 100191, - - 2014
Under the circumstance of the New Medical Reform in Mainland of China, lowering drug prices has become an approach to relieving increase of medical expenses, and lowering brand-name medication price is a key strategy. This study, by comparing and analyzing brand-name medication prices between Mainland of China and Taiwan, explores ...
Go Ryeo-Eun RE Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, - - 2014
According to WHO global estimates from 2008, more than 1.4 billion adults were overweight and among them, over 200 million men and 300 million women were obese. Although the main treatment modalities for overweight and obese individuals remain dieting and physical exercise, the synthetic anti-obesity medications have been increasingly used ...
Catalani Blas B Department of Anesthesiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA. Electronic address: - - 2014
The use of antidepressants, anxiolytics, mood stabilizers, anticonvulsants, and major tranquilizers introduces neurochemical, behavioral, cognitive, and emotional factors that increase the complexity of medical and surgical tasks. Increasingly, various classes of psychotropic medications are being prescribed in the perioperative setting for their analgesic properties in patients with or without a ...
Doherty Leo L 1Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Reproductive Endocrinology and Infertility, Yale School of Medicine, New Haven, CT, - - 2014
Uterine fibroids (leiomyomata) are extremely common lesions that are associated with detrimental effects including infertility and abnormal uterine bleeding. Fibroids cause molecular changes at the level of endometrium. Abnormal regulation of growth factors and cytokines in fibroid cells may contribute to negative endometrial effects. Understanding of fibroid biology has greatly ...
Li Emily H EH PharmD Student, University of Alberta, Edmonton, AB, - - 2014
To summarize the literature regarding antiretroviral and other medication errors in hospitalized HIV-positive patients and to discuss potential interventions and solutions that have been studied to minimize drug error. A systematic search of MEDLINE, PubMed, and EMBASE (2000-April 2014) was conducted. Search terms included HIV/AIDS, HAART, hospitalization, patient admission, inpatient, ...
Stienlauf Shmuel S The Center of Geographic Medicine, The Chaim Sheba Medical Center, Tel Hashomer 52621, Israel; The Departments of Internal Medicine, The Chaim Sheba Medical Center, Tel Hashomer 52621, Israel; The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel. Electronic address: - - 2014
Data regarding the prevalence of potential interactions between travel-related medications (TRM) and chronic medications in use, or medical conditions of travelers to developing countries are limited. A retrospective cohort study of travelers to low income countries. We extracted data on demographics, travel destinations, use of chronic medications, drug allergies, and ...
Barry Arden R - - 2014
To determine the rate of secondary prevention cardiovascular drug utilization in a cohort of patients who underwent coronary artery bypass graft (CABG) surgery—including specific drugs and their dosages, drug adherence, and assessment of targeted therapy--from admission to 1 year after CABG surgery. Retrospective analysis. Cardiovascular quaternary care medical center in ...
Margolin Judith F JF Baylor College of Medicine, Texas Children's Cancer and Hematology Service, Houston, - - 2014
Vascular anomalies (VAs) comprise a large variety of individual diagnoses that in different phases of treatment require a diverse number of medical specialists to provide optimal care. Medical therapies include agents usually associated with cancer chemotherapy, such as vincristine, as well more immunomodulatory types of drugs, such as glucocorticoids and ...
Collado Paz P Department of Rheumatology, Pediatric Rheumatology Unit, Severo Ochoa University Hospital, Madrid, Spain. - - 2014
To determine the prevalence of abnormalities detected by ultrasonography (US) in children with juvenile idiopathic arthritis (JIA) showing clinically inactive disease (ID) on medication and off medication. Inclusion criteria: 1) JIA patients, 2) clinician-determined ID, 3) JIA drugs withdrawal or stably dosed modified anti-rheumatic drugs (DMARDs) therapy for at least ...
Joos E E Pharmaceutical Care Unit, Ghent University, Ghent, - - 2014
The administration of oral medication to patients with an enteral feeding tube (EFT) is challenging. Compliance to guidelines concerning medication administration via EFT has been investigated extensively in the hospital setting. However, studies in residential care facilities (RCFs) for individuals with intellectual disability (ID) are very limited. Therefore, the present ...
Stegemann S S Pharmaceutical Development, Capsugel, Rijksweg 11, 2880, Bornem, Belgium, - - 2014
Drugs represent the most common intervention strategy for managing acute and chronic medical conditions. In light of demographic change and the increasing age of patients, the classic model of drug research and development by the pharmaceutical industry and drug prescription by physicians is reaching its limits. Different stakeholders, e.g. industry, ...
Bénard François F BC Cancer Agency, Vancouver, British Columbia, - - 2014
(99m)Tc is currently produced by an aging fleet of nuclear reactors, which require enriched uranium and generate nuclear waste. We report the development of a comprehensive solution to produce (99m)Tc in sufficient quantities to supply a large urban area using a single medical cyclotron. A new target system was designed ...
Gionfriddo Michael R MR Knowledge and Evaluation Research Unit, Mayo Clinic, 200 First Street SW, Rochester, MN, - - 2014
Clinicians and patients with type 2 diabetes enjoy an expanding list of medications to improve glycemic control. With this expansion has come a flurry of concerns about the safety of these antihyperglycemic agents, concerns that affect judgments about the risk/benefit balance of therapy. Some of these safety signals have been ...
McIntyre Chelsey M CM Chelsey M. McIntyre, Pharm.D., is Clinical Pharmacy Specialist, Drug Information, Department of Pharmacy, and Heather M. Monk, Pharm.D., is Clinical Pharmacy Specialist, Neonatology, Department of Pharmacy, Children's Hospital of Philadelphia, Philadelphia, - - 2014
The gastrointestinal absorption sites of medications administered via postpyloric enteral feeding tubes were examined. Many issues must be considered when administering medications via the postpyloric route, including interactions with enteral feeds, additional toxicities, and the concern of whether the medication will be absorbed. Despite the potential clinical significance of this ...
Lieberman Daniel A DA *Division of Emergency Medicine, Harborview Medical Center, University of Washington, Seattle, WA †Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital and Harvard Medical School, Boston, - - 2014
Medication copayments can influence patient choices. We evaluated 2 copayment policies implemented by Massachusetts Medicaid incentivizing the use of selected generic medications. In 2009, Massachusetts Medicaid copayments were $1 for generics and $3 for brands. On February 1, 2009, copayments for generic antihypertensives, antihyperlipidemics, and hypoglycemics (target medications) remained at ...
Elias W Jeffrey WJ Department of Neurological Surgery, University of Virginia, - - 2014
Tremor, defined as a rhythmic and involuntary movement of any body part, is the most prevalent movement disorder, affecting millions of people in the United States. All adults have varying degrees of physiological tremor so it is imperative to distinguish physiological tremor from pathological tremor types. Tremor is not inherently ...
Ahuja Nitin K Ahuja NK Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, - - 2014
A limited number of medications are typically considered for the management of hepatic encephalopathy occurring as a complication of transjugular intrahepatic portosystemic shunt (TIPS) placement. Multiple alternative compounds aimed at disrupting ammoniagenesis are or will soon be available, though their use tends to be limited by a lack of large ...
Bechis Seth K SK Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, - - 2014
Benign prostatic hyperplasia (BPH) affects over 50 percent of men by age 60 and is the cause of millions of dollars of healthcare expenditure for treatment of lower urinary tract symptoms (LUTS) and urinary obstruction. Despite the widespread use of medical therapy, there is no universal therapy that treats all ...
Kumar Das Kishore K Burns and Plastic Surgery Unit, Dhaka Medical College Hospital, Dhaka, - - 2014
Drugs are by far the most common cause of toxic epidermal necrolysis (TEN), but unidentified drugs and chemicals present in herbal and traditional medications may also be responsible for this reaction, which manifests as widespread epidermal detachment of the skin and mucous membrane. In contexts in which a subject has ...
Okuboyejo Senanu S Covenant University. - - 2014
Non-adherence to prescribed medication and health regimen has been identified as responsible for poor health outcomes. This study investigates the reasons for medication non-adherence in outpatient setting among malaria patients in Nigeria. This research adopted quantitative research methods. A well-structured questionnaire was completed by 440 respondents with minimum age of ...
Woodfield Georgia G University of Bristol Academy at Great Western Hospital, Swindon, Wiltshire, - - 2014
Drug errors are a major cause of patient morbidity. The UK General Medical Council has highlighted that prescribing teaching should be prioritised. How should medical teachers best teach the practical aspects of prescribing? We piloted a set of eight prescribing simulation tutorials for 35 final-year undergraduate medical students in Great ...
George David R - - 2014
The use of synthetic pesticides and repellents to target pests of veterinary and medical significance is becoming increasingly problematic. One alternative approach employs the bioactive attributes of plant-derived products (PDPs). These are particularly attractive on the grounds of low mammalian toxicity, short environmental persistence and complex chemistries that should limit ...
Higgs Paul P 1School of Veterinary Sciences, University of Bristol, Langford, Bristol, - - 2014
Feline hyperthyroidism is commonly diagnosed in general practice. This study assessed the opinions and experiences of UK general practitioners (GPs) regarding the management of feline hyperthyroidism. This included an evaluation of preferred treatment modalities and the monitoring of medically treated cats in relation to thyroxine (T4) level, co-morbid disease and ...
Harding Jacqueline L JL Department of Chemistry, Colorado State University, 1872 Campus Delivery, Fort Collins, CO 80523, - - 2014
When interfaced with the biological environment, biomedical devices are prone to surface biofouling due to adhesion of microbial or thrombotic agents as a result of the foreign body response. Surface biofouling of medical devices occurs as a result of nonspecific adhesion of noxious substrates to the surface. Approaches for biofouling-resistant ...
Howell Leonard L LL Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. Electronic address: - - 2014
The acute and chronic effects of abused psychostimulants on monoamine transporters and associated neurobiology have encouraged development of candidate medications that target these transporters. Monoamine transporters, in general, and dopamine transporters, in particular, are critical molecular targets that mediate abuse-related effects of psychostimulants such as cocaine and amphetamine. Moreover, chronic ...
Nowrangi Derek S - - 2014
Argon is a noble gas element that has demonstrated narcotic and protective abilities that may prove useful in the medical field. The earliest records of argon gas have exposed its ability to exhibit narcotic symptoms at hyperbaric pressures greater than 10 atmospheres with more recent evidence seeking to display argon ...
Ge Liangpeng L Chongqing Academy of Animal Sciences, Chongqing, People's Republic of China ; Key Laboratory of Pig Industry Sciences, Chongqing, People's Republic of - - 2014
Nanosilver particles (NSPs), are among the most attractive nanomaterials, and have been widely used in a range of biomedical applications, including diagnosis, treatment, drug delivery, medical device coating, and for personal health care. With the increasing application of NSPs in medical contexts, it is becoming necessary for a better understanding ...
Sambhara Deepak D University of Illinois College of Medicine at Peoria, Peoria, IL, - - 2014
Lowering intraocular pressure (IOP) is the only proven therapeutic intervention for glaucomatous optic neuropathy. Despite advances in laser and microsurgical techniques, medical IOP reduction remains the first-line treatment option for the majority of patients with open-angle glaucoma. Prostaglandin analogs are the most efficacious topical agents and carry a remarkable safety ...
Stuart Bruce - - 2014
Medicare Part D prescription drug plans must offer medication therapy management (MTM) services to qualified enrollees. Eligibility criteria used by plan sponsors are restrictive, and fewer than 10% of Part D enrollees receive MTM services. The extent to which plan criteria identify beneficiaries most at risk for suboptimal medication use ...
Shen Chan C Departments of Health Services Research and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, - - 2013
There has been a rapid increase in the use of targeted oral anticancer medications (OAMs) in the past decade. As OAMs are often expensive, economic consideration play a significant role in the decision to prescribe, receive or cover them. This paper performs a systematic review of costs or budgetary impact ...
Stevens Jonathan R JR Henry Ford Health Systems, Dearborn, MI; Wayne State University, Detroit, MI. Electronic address: - - 2013
The Black Box Warning (BBW) is the Food and Drug Administration's highest level of drug warning. It signifies that a medication has serious (or potentially life-threatening) side effects and is prominently displayed on a medication's package insert. It literally consists of the medication warning and is surrounded by a bold ...
Sicras-Mainar A A Department of Planning, Badalona Serveis Assistencials SA, Badalona, Barcelona, Spain. Electronic address: - - 2013
To describe the frequency of drug combinations (substrate-substrate or substrate-inhibitor) with the potential to interfere with the CYP2D6 metabolic pathway in patients receiving antidepressant medication for major depressive disorder. We carried out an observational study using outpatient medical records. We included adult subjects who initiated antidepressant medication during 2008-2010. Patients ...
Ferguson Brian Scott - - 2013
A sensor capable of continuously measuring specific molecules in the bloodstream in vivo would give clinicians a valuable window into patients' health and their response to therapeutics. Such technology would enable truly personalized medicine, wherein therapeutic agents could be tailored with optimal doses for each patient to maximize efficacy and ...
Hsu Jason C - - 2013
To control increasing pharmaceutical expenditures, Taiwan's National Health Insurance has implemented a series of drug reimbursement price reductions since 2000. This study examined changes in use and expenditures of oral antidiabetic medications following the price regulation in November 2006. We obtained claims data between January 2006 and August 2007 from ...
Shah Sachil - - 2013
To report a case of difficult-to-treat hypertension ultimately managed with triple antirenin (anti-R) therapy using plasma renin activity (PRA) to guide medication selection. A 66-year-old white man was referred to the cardiology pharmacotherapy clinic for difficult-to-treat hypertension. His initial office blood pressure (BP) was 152/71 mm Hg on diltiazem and ...
Buckley Jessie P - - 2013
Polypharmacy is of growing concern in the chronically ill, including individuals with inflammatory bowel disease (IBD). The authors aimed to describe the prevalence and predictors of non-IBD medication use and to compare drug use among individuals with and without IBD. This cross-sectional study included members of health plans included in ...
Pula John H - - 2013
Systemic medications may cause side-effects manifesting primarily as neuro-ophthalmologic problems. It is paramount for the physician to be updated on both well recognized and novel associations between drugs and their potential adverse reactions. There is a growing list of medications that can cause pupil dilation, pupil constriction, dyschromatopsia, worsening of ...
Shah Sachil - - 2013
To report a case of difficult-to-treat hypertension ultimately managed with triple antirenin (anti-R) therapy using plasma renin activity (PRA) to guide medication selection. A 66-year-old white man was referred to the cardiology pharmacotherapy clinic for difficult-to-treat hypertension. His initial office blood pressure (BP) was 152/71 mm Hg on diltiazem and ...
De Alwis Hemakanthi G - - 2013
A simple, robust LC-UV method was developed to assay erythromycin in medicated salmonid feed. In this method, erythromycin was extracted from feed with acetonitrile and water, cleaned up by SPE, evaporated to dryness, reconstituted, and analyzed by LC-UV. The resulting method produced high accuracy, 82-90%, for both salmon and trout ...
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