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Issa Naiem T NT Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC - - 2014
Advancements in genomics and personalized medicine not only effect healthcare delivery from patient and provider standpoints, but also reshape biomedical discovery. We are in the era of the '-omics', wherein an individual's genome, transcriptome, proteome and metabolome can be scrutinized to the finest resolution to paint a personalized biochemical fingerprint ...
Jahrling Peter B PB Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA; Emerging Viral Pathogens Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, - - 2014
Scientists at the National Institute of Allergy and Infectious Diseases Integrated Research Facility at Fort Detrick, Frederick, Maryland coordinate and facilitate preclinical research on infectious diseases to develop medical countermeasures for high consequence pathogens. This facility is unique in that it is the only maximum containment laboratory in the world ...
Willits Iain I Newcastle upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Freeman Road, Newcastle upon Tyne, NE7 7DN, - - 2014
The Microlife(®) 'WatchBP Home A' oscillometric blood pressure monitor detects irregular pulse, suggestive of atrial fibrillation (AF). Early detection of AF can prevent thromboembolic stroke via anticoagulation therapy. The device was considered by the Medical Technologies Evaluation Programme of the UK National Institute for Health and Care Excellence (NICE). The ...
Branescu I I Faculty of Automatic Control and Computers, Polytechnic University of - - 2014
The paper discusses the methods to apply OLAP techniques for multidimensional databases that leverage the existing, performance-enhancing technique, known as practical pre-aggregation, by making this technique relevant to a much wider range of medical applications, as a logistic support to the data warehousing techniques. The transformations have practically low computational ...
Demmer Laurie A LA Deparment of Pediatrics, Carolinas Medical Center, Charlotte, NC 28232; email: - - 2014
Genomic medicine is a relatively new concept that involves using individual patients' genomic results in their clinical care. Genetic technology has advanced swiftly over the past decade, and most providers have been left behind without an understanding of this complex field. To realize its full potential, genomic medicine must be ...
Carruth Lauren L Global Health & Health Policy Program, Woodrow Wilson School of Public & International Affairs, Princeton University, Princeton, NJ 08540, USA. Electronic address: - - 2014
This paper details how exposure to new clinics, diagnostic technologies, and pharmaceuticals during humanitarian relief operations in the Somali Region of Ethiopia shaped local pluralistic health systems and altered the ways in which residents subsequently conceived of and treated illness and disease. Despite rising demand for pharmaceuticals and diagnostic technologies ...
Leung Alexander A AA From the *Brigham and Women's Hospital, Boston, Massachusetts; †Texas Medical Institute of Technology, Austin, Texas; and ‡Boston Medical Center, Boston, - - 2014
Safety advocates have identified barcode verification technology as an important tool to improve health-care practices. We evaluated the evidence for the role of barcode technology in improving a wide range of medication safety outcomes across a broad range of settings. Important implementation issues were highlighted to guide standards for the ...
Gioli-Pereira Luciana - - 2014
Studies adopting electronic medical records and genomic information are becoming widespread. Through this new modality in research, it is possible to study how genetic variants influence susceptibility towards chronic conditions and can improve patient care.Our aim is to develop a biobank with 2,000 heart failure patients treated in a tertiary ...
Wink Michael M Heidelberg University, Institute of Pharmacy and Molecular Biotechnology, Heidelberg, Germany. - - 2014
This issue of Biotechnology Journal is a regular issue edited by Prof. Michael Wink. The issue covers all the major focus areas of the journal, including medical biotechnology, synthetic biology, and novel biotechnological methods.
Iv Edward C Oldfield EC Edward C Oldfield IV, Edward C Oldfield III, David A Johnson, Division of Gastroenterology, Division of Infectious Disease, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA 23508, United - - 2014
Clostridium difficile infection (CDI) presents a rapidly evolving challenge in the battle against hospital-acquired infections. Recent advances in CDI diagnosis and management include rapid changes in diagnostic approach with the introduction of newer tests, such as detection of glutamate dehydrogenase in stool and polymerase chain reaction to detect the gene ...
Kaiser Stephanie S Institute of History, Theory and Ethics in Medicine, Medical School, RWTH Aachen - - 2014
Objectives: This study explores the awareness and the degree of acceptance of the idea of the medical technology cryonics-the freezing of a corpse to revive it in the future-among German citizens. Methods: Data were collected on the basis of a representatively weighted online survey of 1,000 people aged between 16 ...
Foley Ronan R Department of Geography, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland. Electronic address: - - 2014
The invention of a new form of hot-air bath in Blarney, Ireland in 1856, variously known in its lifetime as the Roman-Irish or Turkish Bath, acted as the starting point for a the production of a globalised therapeutic landscape. Tracking the diffusion of the Roman-Irish bath template from its local ...
Pereira Jorge J CQM - Centro de Química da Madeira, Universidade da Madeira, Campus Universitário da Penteada, 9000-390, Funchal, - - 2014
The human population continues to grow exponentially in the fast developing and most populated countries, whereas in Western Europe it is getting older and older each year. This inevitably raises the demand for better and more efficient medical services without increasing the economic burden in the same proportion. To meet ...
Cassidy Lindsey L Department of Anatomical Sciences, School of Medicine, St. George's University, Grenada, West - - 2014
Friedrich Trendelenburg's name is widely known today because it is associated with the Trendelenburg position. However, Trendelenburg made many other valuable contributions to the field of medicine, including a test, a gait, and a sign. A historical review of his life helps to elucidate the factors that contributed to his ...
Yetisen Ali Kemal AK Department of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, UK. - - 2014
The rapidly expanding number of mobile medical applications have the potential to transform the patient-healthcare provider relationship by improving the turnaround time and reducing costs. In September 2013, the U.S. Food and Drug Administration (FDA) issued guidance to regulate these applications and protect consumers by minimising the risks associated with ...
Gong Max M MM Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, Ontario, Canada M5S 3G8. - - 2014
We present a low cost, simple and integrated device for medical diagnostics in low-resource settings called the lab-in-a-pen. Finger pricking, and sample collection and processing, are integrated with commercially available paper-based assays in a pen format. This approach ensures safety (i.e. biological sample and sharps containment) and can be used ...
Connolly John J JJ The Center for Applied Genomics, Children's Hospital of Philadelphia Philadelphia, PA, - - 2014
The goal of this paper is to review recent research on copy number variations (CNVs) and their association with complex and rare diseases. In the latter part of this paper, we focus on how large biorepositories such as the electronic medical record and genomics (eMERGE) consortium may be best leveraged ...
Bruley Duane F DF Synthesizer, Inc., 2773 Westminster Road, Ellicott City, MD, 21043, USA, - - 2014
The founding of ISOTT was based upon the blending of Medical and Engineering sciences. This occurrence is portrayed by the Shamattawa, the joining of the Chippewa and Flambeau rivers. Beginning with Carl Scheele's discovery of oxygen, the medical sciences advanced the knowledge of its importance to physiological phenomena. Meanwhile, engineering ...
Bubalo Joseph J 1Department of Pharmacy Services, Oregon Health & Science University, OR, - - 2013
PurposeMedical errors, in particular medication errors, continue to be a troublesome factor in the delivery of safe and effective patient care. Antineoplastic agents represent a group of medications highly susceptible to medication errors due to their complex regimens and narrow therapeutic indices. As the majority of these medication errors are ...
Evans Barbara J BJ Center for Biotechnology & Law, University of Houston Law Center, Houston, Texas, - - 2013
The Supreme Court's recent decision in Association for Molecular Pathology v. Myriad Genetics portrays the human genome as a product of nature. This frames medical genetics as an extractive industry that mines a natural resource to produce valuable goods and services. Natural resource law offers insights into problems medical geneticists ...
Finocchiaro Castro Massimo M Mediterranean University of Reggio Calabria, Department of Law and Economics, Via Tommaso Campanella, 38/A, 89125 Reggio Calabria, - - 2013
The aim of this study was to investigate how the differences across the regional reimbursement mechanisms and in particular the use of the DRGs impact on the level in the high technology equipment diffusion. Based on hospital sector data at a regional level we build up indicators to measure the ...
Makiuchi Takashi - - 2013
The mitochondria have arisen as a consequence of endosymbiosis of an ancestral α-proteobacterium with a methane-producing archae. The main function of the canonical aerobic mitochondria include ATP generation via oxidative phosphorylation, heme and phospholipid synthesis, calcium homeostasis, programmed cell death, and the formation of iron-sulfur clusters. Under oxygen-restricted conditions, the ...
Elkin P L - - 2013
Introduction: This article is part of a For-Discussion-Section of Methods of Information in Medicine on "Biomedical Informatics: We are what we publish". It is introduced by an editorial and followed by a commentary paper with invited comments. In subsequent issues the discussion may continue through letters to the editor. Objective: ...
Chen Yang - - 2013
By the end of 2012, there were 272 modern, high-standard, centralized medical waste disposal facilities operating in various cities in China. Among these facilities nearly 50% are non-incineration treatment facilities, including the technologies of high temperature steam, chemical disinfection and microwave. Each of the non-incineration technologies has its advantages and ...
Carnevali Lise - - 2013
Medication-related harm can be detected using the adverse drug event (ADE) trigger tool and the medication module of the Global Trigger Tool (GTT) developed by the Institute for Healthcare Improvement (IHI). In recent years, there has been some controversy on the performance of this method. In addition, there are limited ...
Sim┼ček Enver E Division of Pediatric Endocrinology, Department of Pediatrics University College London, London, United Kingdom. - - 2013
Congenital hyperinsulinism (CHI) is a common cause of hypoglycemia in infants. We report three cases of CHI with differing clinical, biochemical, and molecular genetic spectra. One patient was unresponsive to medical treatment and died after subtotal pancreatectomy because of complications due to the surgery. Two patients have been followed successfully ...
Wang Xiaoliang - - 2013
The severe challenges of the skyrocketing healthcare expenditure and the fast aging population highlight the needs for innovative solutions supporting more accurate, affordable, flexible, and personalized medical diagnosis and treatment. Recent advances of mobile technologies have made mobile devices a promising tool to manage patients' own health status through services ...
Opitz John M - - 2013
In their ontogeny and phylogeny all living beings are historical entities. The revolution in biology of the 18th and 19th centuries that did away with the scala naturae according to which we humans, the acme of creation, "made a little lower than the angels," also led to the gradual realization ...
Nelson Danielle - - 2013
The recent technological advance of digital high resolution imaging has allowed the field of pathology and medical laboratory science to undergo a dramatic transformation with the incorporation of virtual microscopy as a simulation-based educational and diagnostic tool. This transformation has correlated with an overall increase in the use of simulation ...
Sutter Raoul - - 2013
The term encephalopathy encompasses a wide variety of syndromes caused by a large number of different toxic, metabolic, and degenerative derangements. Despite advances in intensive medical care and new diagnostic procedures, encephalopathy remains a frequent and underrecognized critical medical condition with high morbidity and mortality. Electroencephalography (EEG) enables rapid bedside ...
Harlé Alexandre - - 2013
Since January 16(th) 2010, the French legislation requires that the medical laboratories must be accredited according to ISO 15189 standards. Thus, all medical laboratories in France must be accredited for at least part of their biological tests before the end of October 2013. Molecular biology tests are also concerned by ...
Kellman Philip J - - 2013
Recent advances in the learning sciences offer remarkable potential to improve medical education and maximize the benefits of emerging medical technologies. This article describes 2 major innovation areas in the learning sciences that apply to simulation and other aspects of medical learning: Perceptual learning (PL) and adaptive learning technologies. PL ...
Chakravarthi Indira I UGC Fellow, Centre of Social Medicine and Community Health, Jawaharlal Nehru University, New Delhi, - - 2013
Medical devices and equipment have become an indispensable part of modern medical practice. Yet these medical technologies receive scant attention in the Indian context, both at the health policy level and as an area of study. There has been little attempt to systematically address the issue of equipment based medical ...
Nam Jeesoo - - 2013
Biomedical enhancements, the applications of medical technology to make better those who are neither ill nor deficient, have made great strides in the past few decades. Using Amartya Sen's capability approach as my framework, I argue in this article that far from being simply permissible, we have a prima facie ...
- - 2013
The Food and Drug Administration (FDA) is issuing a final rule to establish a system to adequately identify devices through distribution and use. This rule requires the label of medical devices to include a unique device identifier (UDI), except where the rule provides for an exception or alternative placement. The ...
Kiourti Asimina - - 2013
Wireless medical telemetry permits the measurement of physiological signals at a distance through wireless technologies. One of the latest applications is in the field of implantable and ingestible medical devices (IIMDs) with integrated antennas for wireless radiofrequency (RF) communication (telemetry) with exterior monitoring/control equipment. Implantable medical devices (MDs) perform an ...
Vo-Dinh Tuan - - 2013
This article provides an overview of the development and applications of plasmonics-active nanoprobes in our laboratory for chemical sensing, medical diagnostics and therapy. Molecular Sentinel nanoprobes provide a unique tool for DNA/RNA biomarker detection both in a homogeneous solution or on a chip platform for medical diagnostics. The possibility of ...
Nath Debjani - - 2013
The development of eco-friendly technologies in material synthesis is of considerable importance to expand their biological applications. Nowadays, a variety of green nanoparticles with well-defined chemical composition, size, and morphology have been synthesized by different methods and their applications in many cutting-edge technological areas have been explored. This review highlights ...
Grainger David W - - 2013
Biomaterials-associated infection incidence represents an increasing clinical challenge as more people gain access to medical device technologies worldwide and microbial resistance to current approaches mounts. Few reported antimicrobial approaches to implanted biomaterials ever get commercialized for physician use and patient benefit. This is not for lack of ideas since many ...
Ghosh Sangita - - 2013
In the bewildering array of scientific nomenclature in the medical field, it is important to use correct terminology, know their aberrations and the reason behind a specific terminology. This paper is an attempt towards compiling all the pseudo-nomenclatures coined in dermatology, in order to make it easier to retain and ...
Wassenaar Merel - - 2013
One third of all epilepsy patients have medically intractable epilepsy. Knowledge of prognostic factors that, in an early therapeutic stage of epilepsy, herald intractability could facilitate patient management. In this systematic review, we examined the evidence for independent prognostic factors of intractability in patients with epilepsy. MEDLINE and EMBASE were ...
Nguyen Andrew - - 2013
Medical and biological imaging based on radio-wave induced ultrasound with a single source capable of irradiating multiple signals of different frequencies simultaneously can be implemented using ultra-wideband (UWB) technique. Development of a low-cost miniature UWB CMOS transmitter that can be used for this medical application is presented. The UWB transmitter ...
- - 2013
The Editor of Chinese Medical Sciences Journal retracts the following article: Zhen Li, Zhong-gao Wang, Bian Ce, Chen Xiu, Han Bing, Gao-feng Hou, Chu Jian, and Cui Qi. Interferon Regulatory Factor-1 Exerts Inhibitory Effect on Neointimal Formation after Vascular Injury. Chin Med Sci J 2009; 24(2): 91-6. PubMed ID: 19618605. ...
Van der Rijt Rhys - - 2013
Recent advances in digital technology including internet, email and smartphones has revolutionised clinical photography and medical record data storage. The use of smartphones is becoming ubiquitous among medical professionals and the use of clinical photography has become an integral component of the management of patients in a variety of visually ...
Berns Kenneth I - - 2013
My 45 years of studying the molecular biology of adeno-associated virus are recounted. Additional activities as a mentor, department chair, and medical school administrator are described, as are my activities in the public sphere, which involved national issues related to science policy and medical education.
García-Carbonero R - - 2013
The annual incidence of neuroendocrine tumours in the Caucasian population ranges from 2.5 to 5 new cases per 100,000 inhabitants. Gastroenteropancreatic neuroendocrine tumours is a family of neoplasms widely variable in terms of anatomical location, hormone composition, clinical syndromes they cause and in their biological behaviour. This high complexity and ...
Védy Serge - - 2013
As far as molecular biology is concerned, numerous are laboratories using in-house method. Used since many years, medical biologists have often a good practical knowledge about them. According to ISO 15189 accreditation, is this knowledge sufficient for the validation of these methods? We have asked this question ourselves about our ...
Ali Syed A - - 2013
Intra- and interspecific variation in venom composition has been shown to have a major effect upon the efficacy of antivenoms. Due to the absence of domestically produced antivenoms, Pakistan is wholly reliant upon antivenoms produced in other countries, such as India. However, the efficacy of these antivenoms in neutralising the ...
Geer Charlie - - 2013
Working as a medical translator in the Dominican Republic, the author witnesses the healing power of compassion.
Dondorp W - - 2013
This Task Force document revisits the debate about the ethics of sex selection for non-medical reasons in the light of relevant new technological developments. First, as a result of improvement of the Microsort® flow cytometry method, there is now a proven technique for preconception sex selection that can be combined ...
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