Our objectives were to improve the efficiency of rhesus monkey oocyte maturation and fertilization in vitro and to determine the influence of menstrual cycle phase and exogenous gonadotropins on these processes. Immature oocytes were recovered from antral follicles of ovaries excised from unstimulated animals (n = 14). The highest yield ...

Editor's Introduction: The teaching of analytical skills to health workers takes many different forms, and is done in widely divergent institutions and cultures. In recent years medical humanities has been one of the most strongly advocated additions to the undergraduate medical curriculum (the medical humanities were championed in the previous ...

The terms 'humanism' and 'the humanities' are used in the sense of 'learning or literature concerned with human culture' (OED). The Irish medical exponents described are Richard Stanyhurst, Edward Hill, James Henry, John Knott and some others. It is argued that literary studies do not humanize but offer subtle and ...

No two agencies provide care in the exact same way. Thus, it is difficult to come up with a definitive description of what a medical director should do. But one medical director undertook a description; through intense examination of his personal perspective and his professional experience, he presents a total ...

BACKGROUND: Fibrel is a medical implant device that has demonstrated use in the correction of cutaneous depressions from acne scars and wrinkles. OBJECTIVE: Mechanisms of actions have been proposed that have theorized the production of new collagen over time as a result of the Fibrel implant. The present study utilized ...

Prior to the mid-1980's, human rights abuses were documented almost entirely through witness and victim testimony. In 1984-85, forensic scientists from the United States, working under the auspices of the American Association for the Advancement of Science, exhumed skeletal remains of disappeared persons in Argentina. They provided physical evidence for ...

Human subjects were fed with extract of three Chinese herbs, Panax ginseng, Panax quinquefolium roots and Ganoderma lucidum. Pulse of the radial artery was examined. Our results indicate that each herb has a specific effect on the Fourier components of the pulse, and is in agreement with traditional Chinese medical ...

With substantial improvements in analytic techniques over the past decade, it has become possible to measure polychlorinated dioxins (PCDDs) and dibenzofurans (PCDFs) in human tissue in a congener-specific fashion down to the low parts per trillion level. This paper reviews findings using these new techniques from a number of recent ...

We studied the effects of cimetidine, ranitidine and famotidine on the kinetics of naproxen. The mean t1/2 beta of naproxen in 6 subjects was 25.7 +/- 5.4 h (range 16 to 36). Naproxen acyl glucuronide accounts for 50.9 +/- 6.9% of the dose, its isomerized isoglucuronide for 6.8 +/- 2.6%, ...

The dangers of occupational infection (where the infectious agent was acquired during the provision or receipt of a medical service) have received renewed interest in the era of the human immunodeficiency virus. The dilemmas raised by this phenomenon, however, are far from novel and were the subject of considerable debate ...

Since the dawn of human history, the inherent morbidity and mortality of human beings has made the diagnosis and treatment of human disease a high-risk profession. The ancient risk of physical retribution against the physician has been replaced by the modern risk of economic indemnity or compensation. Monetary settlements and ...

Today clinical toxicology and poisons control are widely lacking objective criteria, e.g., analytical data, figures of kinetics and metabolism in acute and chronic poisoning. Co-operation between clinical toxicology and an environmental specimen bank for human tissue will help to overcome many difficulties and complement one another. The possible power of ...

The meteorotropic reaction of the human organism is a function of different factors, such as the type and intensity of the effects of the physical environment as well as individual conditions like adaptive capacity and state of health. Many medical-meteorological studies show causal correlations between conditions in the lower atmosphere ...

Humanism and the humanities open the way to communication, to a better professional and political performance, and to a better image of the profession in the eyes of its "real" public. They also offer to individual physicians a richer life, a greater understanding of their own achievements, a protection against ...

This study investigates the three major educational philosophies behind the medical humanities programs in the United States. It summarizes the characteristics of the Cultural Transmission Approach, the Affective Developmental Approach, and the Cognitive Developmental Approach. A questionnaire was sent to 415 teachers of medical humanities asking for their perceptions of ...

We report here the second case of Candida utilis infection in humans. The patient was apparently immunocompetent, had no central catheter, and survived an 8-day fungemia. Genomic analysis confirmed the conspecificity of medical and industrial strains of C. utilis and that of the anamorphic yeast C. utilis with the teleomorphic ...

Splenopentin (DA SP-5) is a pentapeptide corresponding to the amino acid sequence 32-36 (Arg-Lys-Glu-Val-Tyr) of the splenic hormone splenin. We examined the influence of DA SP-5 on bone marrow progenitor cell (BMC) proliferation. DA SP-5 acts as a co-stimulant for recombinant human granulocyte-macrophage colony-stimulating factor (rHuGM-CSF) in the induction of ...

The exact site of the reentrant circuit in AV nodal reentry remains controversial. While recent ablative techniques have yielded information, the interpretation of which suggests that the atrium is required, other explanations for these interpretations are available. Prior pathophysiological studies with three-dimensional reconstruction of the node suggest that it is ...

Metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent pulmonary carcinogen, have been quantified in the urine of 11 smokers. They were not detected in nonsmokers' urine. The metabolites, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronide, were detected in quantities of 0.23-1.0 and 0.57-6.5 micrograms/24 h, respectively. The results of this study provide the ...

NIDA's MDD is faced with the formidable task of identifying, characterizing, and developing new chemical entities to combat substance abuse. The primary challenge is to find one or more medications that will be useful in treating cocaine addiction, withdrawal, and abstinence. In addition, a treatment for cocaine overdose is in ...

In this paper I shall take the Geneva Conventions and Additional Protocols as my point of departure and link these with the International Declaration of Human Rights as a statement of faith and of aspirations.... The second part of my paper will focus on medical morality with brief reference to ...

Six hundred older Canadians wrote narratives about the meaning of being a senior. The narratives were analyzed and descriptions of simile, paradox, and humor were extracted. Two paradoxical experiences--sameness-yet-difference and restriction-yet-expansion--were described as seniors shared the mystery of later life. They specified three aspects of humor to shed light on ...

Examples of cases where partial remains of the same individual were recovered at different times and from separate locations are presented. Such remains raise unique problems for coroner/medical examiners and police because their discovery has the potential to confound identification and disrupt investigative continuity. Recovered partial human remains highlight the ...

Immediately after the liberation of Kuwait by a coalition of allied forces in March 1991, representatives of Physicians for Human Rights traveled to Kuwait and conducted an inquiry into human rights violations allegedly perpetrated by Iraqi forces. The inquiry focused on the abuses that were said to have occurred in ...

Human tissue is used in an increasing number of medical and scientific contexts. Despite this, the law has traditionally regarded such tissue as having no status in law. This paper provides an overview of the issue of property rights in human corpses, cadaveric specimens, donated living tissue, and human tissue ...

Absidia cylindrospora and Rhizomucor pusillus causal agents of phycomycoses, were cultured on sterile natural keratins in a mineral solution and the keratin degradation products analyzed. The excess of sulphur was removed by oxidation to inorganic sulphate and thiosulphate, which were the main products of sulphitolysis of keratin. The proteolytic activity ...

"The Iliac Passion" traces a return from the new but busy and rapidly growing discipline of "bioethics" to its source in "fundamental philosophical inquiry." The dilemma between bioethics and medicine is examined in two ways. First, the philosophical concept of the "big question" is presented. If we ask of life ...

In vitro fertilization and embryo transfer (IVF) may be considered as a particular application of modern medical therapeutics linked to human reproduction. The treatment of human sterility therefore involves some fundamental human values such as life, love and death. The quality of this highly technological treatment with fast knowledge of ...

What we regard as 'normal' or 'natural' with respect to human female reproductive physiology differs greatly from the reproductive cycle experienced during most of human existence. Frequent ovulatory menstrual cycles really represent repeated abortive reproductive cycles and are unphysiological. A number of medical conditions, some of great importance, are the ...

The ciguatoxins are lipid soluble polyether compounds which have structural and biochemical features in common with the brevetoxins. Pure ciguatoxin-1, ciguatoxin-2 or brevetoxin-2 added to water containing Gambusia affinis induced similar signs, including pronounced opercular movement and uncoordinated swimming preceding death. The estimated LD50s (48 hr) to G. affinis for ...

P1 (HP1) and P2 (HP2, HP3, HP4) protamines were isolated from human sperm nuclei in the reduced form and their interaction with zinc and cobalt was studied. One zinc atom per molecule of P2 protamines but not of P1 protamine was found. Absorption spectra of P2 protamines with cobalt were ...

Despite widespread industrial use of copper naphthenate, there are no reports of the relationship of copper naphthenate and copper absorption in humans or animals. We report a family of three individuals who lived in a home where copper naphthenate was sprayed on the inner foundation. Subsequently, these individuals developed non-specific ...

Elevated levels of aluminum in brain tissue have been found in demented patients with Alzheimer's disease, with ALS-PD complex of Guam and with dialysis encephalopathy. A possible etiological relationship between enhanced aluminum exposure and impaired mental function was suggested both for ALS-PD of Guam (a region where high contents of ...

Over the past decade, the emergence of Aeromonas species as bona fide human pathogens and their probable role as etiologic agents of bacterial gastroenteritis have resulted in an explosion of scientific interest in the genus. Major accomplishments occurring in this field during that interval include a more refined taxonomy, identification ...

This is a brief summary of the development of our understanding of the anatomy and physiology of the human placenta. The article also traces the origin of some of the commonly used terminology that pertains to the placenta, and it makes reference to the major discoveries made in the understanding ...

The Human Genome Project represents a government supported effort to map and sequence the human genome. Governmental support for the Project should include increased emphasis on grants and contracts to industry. This is particularly true for small highly innovative biotechnology companies that can rapidly integrate and use technology as a ...

A variety of evidence suggests a 'dopamine hypothesis' for the reinforcing properties of cocaine. This hypothesis proposes that cocaine binds at the dopamine transporter and mainly inhibits neurotransmitter re-uptake; the resulting potentiation of dopaminergic neurotransmission in mesolimbocortical pathways ultimately causes reinforcement. This model suggests potential medications for treatment of cocaine ...

There are many interacting factors that contribute to understanding the effects of gravity and microgravity on human gravitational physiology. Medical practitioners are interested in maintaining human health and performance in the space environment and thus have concerns regarding what biological questions should be addressed during human space excursions. Communication between ...

A silver sulfadiazine-impregnated poly-L-leucine wound dressing, AgSD-medicated wound dressing, was evaluated for antibacterial capacity against Pseudomonas aeruginosa and cytotoxicity to human fibroblasts and human epidermal keratinocytes. This wound dressing contained 0.4 mg AgSD/cm2. Antibacterial capacity was examined on experimentally infected wound surfaces (3.4 x 10(4) P. aeruginosa organisms/gm) on the ...

In order to settle the question of when saltpetre (nitrate) came in use as an additive to human food, a number of historic cookery books from Germany and Austria were reviewed. Obviously, the change from vegetable dyes to saltpetre for the coloring or color preservation, respectively, of meat occurred between ...

It is generally accepted from animal studies that the medial vestibulospinal tract originates in the medial vestibular nucleus, which is supplied from the semicircular canals, and descends only to the upper thoracic levels of the cord. In humans, however, there is some indirect evidence to support the concept that impulses ...

A major problem which must be overcome before on-line medical records become widely accepted and used is the interface between the human and the computer. This paper presents the evolution of an interface, over time, which recognizes and addresses important characteristics a system must exhibit to encourage human acceptance. Areas ...

Diagnostic ultrasound is an established, noninvasive and harmless method for imaging the shape and appearance of organs and other tissues inside the body, and it has been used in many clinical applications for more than three decades. We have now applied some of this well-known technique together with the use ...

Yeast KEX2 protease was examined as a potential model for a human proprotein convertase and, in all respects, mimicked the predicted properties of a proalbumin convertase. The enzyme rapidly cleaved the propeptide Arg-Gly-Val-Phe-Arg-Arg from the NH2-terminal end of proalbumin but, unlike trypsin, failed to cleave physiologically unprocessed human proalbumin variants. ...

The present study was designed to determine the effects of gestrinone (R2323) in the process of follicle rupture and oocyte maturation and degeneration in an in vitro perfused rabbit ovary model. In the first experiment, R2323 at 10(2), 10(3), or 10(4) ng/ml was added to the perfusate of one ovary. ...

Fact-finding missions (FFMs) are useful instruments in examining allegations of human rights violations. The United Nations Convention against Torture and other Cruel Inhuman or Degrading Treatment and the European Convention for the Prevention of Torture and Inhuman and Degrading Treatment or Punishment include the possibility for FFMs. The role of ...

Altitude-related medical problems have received much attention in the recent medical literature. Family physicians must be knowledgeable about these problems so that they can give appropriate advice to travellers. The author, a practising family physician, discusses issues arising from both the modest cabin altitudes experienced in modern-day air travel and ...

The adsorption of human salivary mucins (HWSM, 0.4 mg/ml) onto hydroxyapatite (HAP) was studied in the presence of varying amounts of the phosphoprotein phosvitin by three different procedures. a. Preadsorption of HWSM onto HAP for 20 h, followed by 4 h coadsorption with phosvitin, resulted in a decrease of 50% ...

We have investigated keratin interactions in vivo by sequentially extracting water-insoluble proteins from normal human epidermis with increasing concentrations of urea (2, 4, 6, and 9.5 M) and examining each extract by one- and two-dimensional gel electrophoresis, immunoblot analysis using monoclonal anti-keratin antibodies, and EM. The viable layers of normal ...

Differences in the shapes of the Hunter-Schreger bands in different teeth and in different areas of a tooth have never been explained. They are almost certainly related directly to differences in the courses and organization of prisms. A computerized model was used to construct vertical sheets of enamel prisms whose ...