P29 is an oestrogen receptor-associated protein which acts as a marker of oestrogen action in several systems. The concentration of P29 was measured in placenta and decidua from women following medical termination of pregnancy with the antiprogesterone steroid mifepristone (RU 38,486) and a prostaglandin E1 analogue, and compared with the ...

E.B. White's Charlotte's Web serves as an environmental parable for our time. As we reflect on our relationship with nature, we might consider the three ways in which Wilbur the pig was valued in White's story. His instrumental value cashes out in ham hocks and sausage. His aesthetic value earns ...

Use of V1 and V6 has been suggested for distinguishing aberrant supraventricular from ventricular ectopy. For two decades, "modified" leads MCL1 and MCL6 have been widely used as V1 and V6 substitutes for bedside monitoring, but their use has never been validated. To determine the value of MCL1 and MCL6, ...

Twelve case stories were mailed to 273 general practitioners to study the clinical assessment of haemoglobin values. For each case the general practitioner was asked to fill in the haemoglobin value representing the minimal change from a given value considered necessary to take action. haemoglobin change corresponding to the median ...

The Resource-based Relative value scale, RBRVS, the sweeping reform in how physicians will be paid, is not the only change being made in Medicare. The federal government has just issued new rules and a new "Fraud Alert" interpreting Medicare's anti-kickback statute, focusing on the business relationships between medical providers and ...

The principal question of this paper is: Why are religious values special in refusal of lifesaving medical treatment? This question is approached through a critical examination of a common kind of refusal of treatment case, one involving a rational adult. The central value cited in defence of honouring such a ...

An unidentified metabolite of dimetridazole (DMZ), found in pig plasma, muscle and kidney, was shown by chromatography and spectroscopy to be 2-methyl-5-nitroimidazole (2-MNI), resulting from N-demethylation of DMZ. This route of degradation competes with the oxidation pathway previously described. The concentration of 2-MNI in the plasma of pig fed medicated ...

A study of clinical medical ethicists was conducted to determine the various philosophical positions they hold with respect to ethical decision making in medicine and their various positions' relationship to the subjective-objective controversy in value theory. The study consisted of analyzing and interpreting data gathered from questionnaires from 52 clinical ...

A simple, rapid, and sensitive single-sweep polarographic method has been developed for investigation of concanavalin A (con A) and its interaction with selected polysaccharides. In a solution containing 0.001 M 2,2'-bipyridine, 0.015 M hexamethylenetetramine, and 0.1 M sodium chloride, con A exhibits a single-sweep polarographic wave, and the cathodic peak ...

We compared a computed strain gauge plethysmograph (SGP1) with a Gutmann strain gauge plethysmograph (SGP2) and a photoplethysmograph (PPG) in 24 normal and 12 radiologically proven postphlebitic limbs with respect to assessment of the calf pump function, discrimination between normal and pathologic values, and handling. Recovery time (RT50), refilling volume ...

Formulations used for control of German cockroaches, Blattella germanica (L.), were investigated. The insecticides tested on gravid females were bendiocarb, chlorpyrifos, cyfluthrin, cypermethrin, fenvalerate, hydramethylnon, malathion, propetamphos, propoxur, and pyrethrins. Exposure to each insecticide increased the frequency of oothecal drop and reduced the percentage oothecal hatch. The percentage of oothecae ...

This paper evaluates the accuracy of Kersey's method of calculation of the dose level due to photoneutrons at the maze entrance of medical accelerators. In this study measurements and calculations of the neutron dose equivalent were made for 13 medical accelerator facilities. The group of accelerators was composed of four ...

In a previous paper, the authors described three paradigms applicable to automated medical text analysis. In this paper, the relative importance of the three paradigms is discussed, viz. the relative value of the linguistic word categorization, the semantic paradigm, and the medical fact delineation. The strategy adopted was to limit ...

This investigation offers a comprehensive analysis of the relative social prestige of various medical specialties. The specialties were evaluated in terms of ascribed esteem by a lay sample of 400 respondents. Several attributes were then tested in order to measure their contribution to overall prestige. The results affirm that a ...

Two commercially available computer-automate semen analysis instruments (CellSoft Automated Semen Analyzer and HTM-2000 Motion Analyzer) were compared for their ability to report similar results based on the analysis of pre-recorded video tapes of extended, motile stallion semen. The determinations of the percentage of motile cells by these instruments were more ...

The non-sedating, second-generation H1-receptor antagonists such as terfenadine, astemizole, loratadine and cetirizine differ considerably from each other in their pharmacokinetics and pharmacodynamics. They are generally well absorbed when administered orally. They have extremely variable serum elimination half-life values. The maximum antihistaminic effect of these medications occurs several hours later than ...

In contrast to clinical practice, the objective of medical surveillance in a workplace population with potential exposure to hepatotoxins is to detect people with occupation-associated liver dysfunction who either have or are at risk for developing clinical disease. Ideally, medical surveillance tests for hepatotoxicity should have, either alone or in ...

A prospective study was performed to assess the effectiveness of the API 20E in the identification of 183 Yersinia isolates incubated at 28 degrees C for 18 to 24 h. The results showed an overall correct-identification rate of 90%, with positive predictive values for Yersinia enterocolitica and Yersinia frederiksenii of ...

We describe a preliminary retrospective study based on the concentration of two hydroxylated metabolites of oxcarbazepine (OCZ), a new anticonvulsant substance, measured in the plasma of 15 patients with epilepsy. Their ages ranged from 8 to 68 years, 6 of them also received phenobarbital and/or phenytoin as co-medication. The concentration ...

To assess the effects of left ventricular (LV) load on isovolumic relaxation rate of the hypertrophied LV, wide range LV load shifts were imposed by the sequential use of balloon aortic valvuloplasty (BAV) and arterial vasodilation in 14 patients with severe sclerocalcific aortic stenosis (aortic valve area, 0.45 +/- 0.16 ...

The ability of the Datex Deltatrac (Sensor-Medics, Anaheim, CA) to accurately measure oxygen consumption (VO2v) and carbon dioxide production (VCO2) was examined in vitro using the carbon dioxide addition and nitrogen dilution methods. The accuracy of respiratory quotient (RQ = VCO2/VO2) measurements was assessed using methanol combustion (RQ = 0.67). ...

Disturbances of the topographical distribution of theta activity in the EEG spectra before and during voluntary movements were investigated in 31 neuroleptic-treated and in 13 untreated schizophrenics and matched controls as well as in 15 normals medicated with haloperidol. All 4 groups demonstrated similar topographical distribution of theta mean power ...

Clonal studies of adult chimaeric mouse epithelium have demonstrated the monoclonal composition of crypts of Lieberkühn. In neonatal life, however, polyclonal crypts have been found, indicating that crypts are of polyclonal origin. We here relate these findings to studies of mosaic tissues which have addressed the question whether solid tumours ...

Endogenicity has been considered to have a major predictive value as to the therapeutic response to antidepressants. Two recently introduced measures of endogenicity (the Michigan Discriminant Index and the Hamilton Endogenomorphy Subscale) were investigated regarding their potential predictive value. It was concluded that, in a group of selected depressive patients, ...

Twelve parishes in Northumberland and County Durham were used to estimate the accuracy of Anglican marriage registers as indicators of migration between birthplace and marriage. We compared entries in the marriage registers with the annotated baptismal registers which exist for most Northumberland parishes from 1798-1812, and which explicitly document the ...

In an effort to clarify the issue of potentially false increases in creatine kinase (EC 2.7.3.2) MB isoenzyme (CK-MB) in uremia, we evaluated the CK profile of 84 persons undergoing chronic maintenance hemodialysis. We compared the performance of a new commercial two-site chemiluminometric immunoassay of CK-MB (Magic Lite; Ciba Corning ...

Monoamine metabolites and norepinephrine (NE) in the cerebrospinal fluid of patients with cerebrovascular dementia were measured to study the effects of administration of idebenone. Six patients with cerebral infarction and one with cerebral hemorrhage (mean age 65.4 years) were enrolled as subjects. All the patients had mental and intelligence impairment ...

Serum and salivary cortisol release and mood ratings were measured in response to the procedure of LHRH tests in 12 medical students professionally familiarized with venipunctures (familiarized subgroup) and in 5 non-medical students (unfamiliarized subgroup). There were significant differences in cortisol and mood ratings between both groups. Only the unfamiliarized ...

Cholinesterase activity measurements for 542 California agricultural pesticide applicators under medical supervision during the first 9 months of 1985 were analyzed. Twenty-six workers, 4.8% of the sample, had cholinesterase values at or below the California threshold values for removal from continued exposure to cholinesterase-inhibiting pesticides (60% of baseline for red ...

We evaluated the Seralyzer instrument for the assay of serum cholesterol and compared it to the Kodak Ektachem method. The Seralyzer showed good accuracy in the analysis of cholesterol in Abell-Kendall-verified serum pools, and the bias from the expected value was small in all cases but one. The Seralyzer exhibited ...

Experienced dermatologists regularly use a great variety of topical dermatologic mixtures. Extemporaneously prepared medications are of great value in the treatment of those problems that fail to respond to the usually therapeutic commercially available products. These mixtures are also desirable in treating individuals in whom corticosteroid preparations were initially beneficial ...

One hundred and forty fecal specimens were tested for rotavirus using two immunoassays, TESTPACK Rotavirus and Pathfinder Rotavirus. Five discordant specimens were evaluated by a blocking assay. The sensitivity, specificity, positive predictive value, and negative predictive value were 98, 100, 100, and 99% for TESTPACK and 92, 100, 100, and ...

Orosomucoid (ORM) phenotyping has been performed on 329 unrelated Swiss subjects, using immobilized pH gradients with 8 M urea and 2% v/v 2-mercaptoethanol followed by immunoblotting. After desialylation the band patterns of ORM confirmed that the polymorphism of the structural locus ORM1 is controlled by three codominant autosomal alleles (ORM1*F1, ...

For hydrodynamic comparison, 11 mechanical bileaflet valves have been perfused in a mock circulation system under pulsatile flow conditions. Six St. Jude Medical valves with different sizes from No. 21 to No. 31 and five Duromedics prostheses with corresponding sizes from No. 21 to No. 29 have been investigated. Flow, ...

Radon-222 and 220Rn progeny are found in some Canadian underground U mines. Because both can contribute to lung dose, their experimental determinations are important. The relationship between 222Rn progeny Working Level [WL(Rn)] and 220Rn progeny Working Level [WL(Tn)] has been investigated in U mines. Experimental measurements extended from 1981 to ...

A mobile fluoroscope was used to measure tibial torsion bilaterally in a random sample of 100 adults without a medical history of injury to the lower extremities. From a chosen neutral position, the difference in torsion between the right and the left tibia in the same subject ranged from -11 ...

Base substitution mutagens were isolated and concentrated from sweat and urine of 7 patients treated with cyclophosphamide and other antineoplastic drugs. These samples were tested in Salmonella typhimurium TA 1535. The perspiration samples were collected under normal physiological conditions for 8 h after medication and urine samples were collected 8 ...

We evaluated the analytical performance of the immunoprecipitation technique for quantification of creatine kinase (CK; EC 2.7.3.2) isoenzyme MB, focusing on specimens with increased blank activities. The samples we studied had blank values that were equal to or greater than either 15 U/L or the uncorrected CK-MB value. Of 134 ...

The utilization of D-3-HB and the production of acetoacetate by the perfused rat heart were investigated over a wide range of DL-3-HB concentrations. The rate of D-3-HB utilization is concentration dependent, and shows saturation kinetics. The oxidized amount of D-3-HB when D-3-HB as a sole substrate, accounts at a maximum ...

The ability was examined of three commercial turkey semen diluents, Beltsville Poultry Semen Extender II (BPSE), Instruments for Veterinary Medicine (IMV), and Minnesota Turkey Growers Association (MTGA) and two diluents containing antibiotics, BPSE + tobramycin (T) and MTGA + gentamicin (G), to maintain the fertilizing capacity of turkey semen held ...

Some of the drawbacks are discussed associated with hygienic norms for gaseous sterilizing agents in polymeric products for medical applications. A new approach is proposed for regulating ethylene oxide (EO) in such products. To this end, limiting types of biological effect and its pathways have been determined and substantiated as ...

The benzodiazepine derivative flurazepam (FLZ) is widely used as a hypnotic, but the relative contributions of FLZ and its metabolites desalkylflurazepam (DA-FLZ), hydroxyethylflurazepam (ETOH-FLZ), and flurazepam aldehyde (CHO-FLZ) to overall clinical activity remain uncertain. A single 20 mg/kg dose of FLZ.HCl was administered to mice, with plasma and brain concentrations ...

Effects of common processing and cooking methods on sugar and starch contents and starch digestibility (in vitro) of mung bean (Vigna radiata L.) were investigated. Soaking reduced the level of total soluble sugars, reducing sugars, non-reducing sugars and starch and improved starch digestibility, significantly. Cooking (both ordinary and pressure cooking) ...

Results are described on the association of decreased serum total thyroxine (T4) and free thyroxine index (FTI) with antiepileptic drug therapy in a group of randomly selected chronically medicated outpatients (n = 291). For monotherapy subgroups (n = 164), the highest incidence (T4, 23.9%; FTI, 25.4%) of below normal values ...

A newly developed computer model is used to predict the aqueous salt solution concentration, breathing pattern, and inhaled droplet size distribution parameters that will maximize pulmonary deposition of hygroscopic medicinal aerosols. The parameter values providing maximum pulmonary deposition include 1) a NaCl concentration in the aerosolized solution of 0.035 g/ml ...

Urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion in two consecutive collection periods (5:00 PM-11:00 PM and 11:00 PM-8:00 AM) and whole blood serotonin (5-HT) and tryptophan (TRP) were measured in groups of unmedicated autistics (n = 16), medicated autistics (n = 20), and normal controls (n = 27). Whole blood 5-HT values ...

Meat tenderizer containing the proteolytic enzyme papain was tested for therapeutic efficacy in the sting of the imported fire ant. The parameters of pain and itching were used to evaluate qualitatively the sting response in 22 healthy medical students, and the laser Doppler velocimeter was used to assess quantitatively the ...

This paper describes the conversion of an autoclave, previously controlled by a bottle simulator and monitored using MTRs, to one controlled by a bottle probe and monitored using F0 values. Temperatures were recorded with a portable data logger and a micro-computer was used to calculate F0 values and produce batch ...

Of 105 admissions to a medical service, 64 involved anemia (defined as a hematocrit value of less than 38%) at some time during the admission. Chart review revealed that the disease concept was not being used, as most of the anemias were unnoticed or undiagnosed, and most of the diagnoses ...

The use of automated analysers in population screening for beta-thalassaemia has been a matter of controversy. The new fully automated haematology analyser Sysmex E-5000 (Toa Medical Electronics Co. Ltd) facilitates the discrimination of heterozygous thalassaemia from iron deficiency anaemia. In addition to haemoglobin, mean corpuscular haemoglobin and mean corpuscular volume, ...