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- - 2014
The Omnio app is the digital equivalent of a medical 'black bag' for carrying around favourite clinical references and bits and pieces.
Turner Aaron P - - 2014
Objective: To evaluate the impact upon medication adherence of brief telephone-based counseling using principles of motivational interviewing and telehealth home monitoring. Design: Randomized controlled pilot trial of 19 veterans with multiple sclerosis (MS) currently prescribed disease modifying therapy (DMT) who endorsed missing doses. Follow-up was conducted at 1, 3, and ...
Yamamoto Hisae H Department of Gastroenterology, Tokyo East Hospital, Tokyo, - - 2014
Although midazolam is widely used during endoscopic procedures by endoscopists, propofol has been recently favored for its rapid action and metabolism. The aim of this study is to compare the clinical advantages between propofol and midazolam use during screening esophagogastroduodenoscopy (EGD) for gastric cancer and post-procedure management at a medical ...
Lewis Brandy L BL Division of Neurology, Brain Research Center, The University of British Columbia, Vancouver, BC, - - 2014
While living with others has been associated with improved functional outcome after acute stroke, it is unclear if this affects adherence to stroke prevention measures. We examined the relationship between living arrangements and adherence to antiplatelet therapy assignment and participation status in an international randomized trial for secondary stroke prevention. ...
Baribeau Danielle A DA Department of Psychiatry, University of Toronto, Toronto, ON, - - 2014
Autism spectrum disorder is often comorbid with behavioral disturbances such as irritability, aggression and hyperactivity. Throughout the mid 2000s, several large-scale controlled clinical trials were published leading to the approval of two medications (aripiprazole and risperidone) for treatment of irritability in this condition. This review serves as an update regarding ...
Chan Kenneth K KK Faculty of Medicine, University of British Columbia, Vancouver, BC, - - 2014
Thoracic aortic dissection (TAD) is a severe and often lethal complication in people with hypertension. Current practice in the treatment of chronic type B aortic dissections is the use of beta-blockers as first-line therapy to decrease aortic wall stress. Other antihypertensive medications, such as calcium channel blockers (CCBs), angiotensin-converting enzyme ...
Tran Nancy N University of Vermont College of Medicine, Burlington, - - 2014
Abstract Objective: One of the most common reasons for medication non-adherence for asthma patients is forgetfulness. Daily medication reminder system interventions in the form of text messages, automated phone calls, and audiovisual reminder devices can potentially address this problem. The aim of this review was to assess the effectiveness of ...
Binning Mandy J MJ Capital Institute of Neurosciences, Capital Health Systems, Trenton and Pennington, New - - 2014
: Stroke is the fourth leading cause of death in the United States. Intracranial atherosclerotic disease accounts for 8%-10% of ischemic stroke in the United States. So far, surgical bypass has not proved to be superior to medical therapy. As both medical and endovascular therapies for intracranial atherosclerosis evolve, so ...
Snyder Stephanie S Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1071, - - 2014
Poor adherence of acne patients to treatment may equate to poor clinical efficacy, increased healthcare costs, and unnecessary treatments. Authors have investigated risk factors for poor medical adherence and how to improve this difficult problem in the context of acne. This systematic review aims to describe what methods have been ...
Jampel Henry D HD Wilmer Eye Institute, Johns Hopkins University, Baltimore, - - 2014
IMPORTANCE While medication efficacy is well documented in clinical trials, less is known of medication effectiveness in real-world clinical settings. OBJECTIVE To assess the effectiveness of intraocular pressure (IOP)-lowering medications in patients with open-angle glaucoma. DESIGN, SETTING, AND PARTICIPANTS Prospective, multicenter, interventional cohort from the prerandomization phase of a randomized ...
Matthes Jan J Department of Pharmacology, University of Cologne, Department of Psychosomatics and Psychotherapy, University Hospital of - - 2014
A common problem among patients with chronic diseases is poor adherence with prescribed medication. Studies have shown that certain interventions can improve adherence and clinical outcomes. We selectively searched the PubMed database for publications on the treatment of hypertension that contained the terms "adherence," "drug," "treatment, "outcome," "hypertension," and "randomized ...
Yang Youngran - - 2014
Incorrect or inconsistent adherence to antiretroviral therapy (ART) compromises the effectiveness of medications and the patient's chances of achieving viral suppression; near-perfect (>95%) compliance is required for both immediate and long-term clinical success. This report presents a systematic review of a multicomponent intervention to address adherence to ART and explores ...
Vaughan Barney B Columbia University/New York State Psychiatric Institute, 1051 Riverside Drive, Unit 66, New York, NY 10032. Electronic address: - - 2014
Psychopharmacology and psychotherapy are the two main therapies in mental health. It is common practice to consider adverse events (AEs) of medications, but it's not clear this occurs with psychotherapy. his study investigates the frequency with which reports of AEs occur in clinical trials using either psychopharmacology alone, psychotherapy alone, ...
Selvaraj Senthil S Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of - - 2014
News coverage of medical research is followed closely by many Americans and affects the practice of medicine and influence of scientific research. Prior work has examined the quality of media coverage, but no investigation has characterized the choice of stories covered in a controlled manner. We examined whether the media ...
Weinman Danielle D Albert Einstein College of Medicine, Bronx, NY, - - 2014
Tension-type headache is highly prevalent in the general population and is a consistent if not frequent cause of visits to acute care settings. Analgesics such as nonsteroidal anti-inflammatory drugs, acetaminophen, and salicylates are considered first-line therapy for treatment of tension-type headache. For patients who present to an acute care setting ...
Frank Jeffrey I JI From the Departments of Neurology (J.I.F., C.K.), Health Studies (L.P.S., K.W., R.A.T.), Statistics (R.A.T.), Anesthesia and Critical Care (R.A.T.), The University of Chicago, IL; Department of Neurosurgery, Mayo Clinic College of Medicine, Rochester, MN (D.C.); and Department of Neurology, Weill Cornell Medical College, New York - - 2014
Hemicraniectomy and Durotomy Upon Deterioration From Infarction-Related Swelling Trial (HeADDFIRST) was a randomized pilot study to obtain information necessary to design a Phase III trial to evaluate the benefit of surgical decompression for brain swelling from large supratentorial cerebral hemispheric infarction. All patients with stroke were screened for eligibility (age ...
Schmitz Joy M JM Department of Psychiatry and Behavioral Sciences, University of Texas, Houston, United States. Electronic address: - - 2014
Cocaine pharmacotherapy trials are often confounded by considerable variability in baseline cocaine-use levels, obscuring possible medication efficacy. Testing the feasibility of using a prerandomization, abstinence-induction protocol, we screened three candidate medications to explore treatment response in patients who did, or did not, achieve abstinence during an extended baseline phase. Eligible ...
Kurihara Chieko C Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba, - - 2014
International norms and ethical standards have suggested that compensation for research-related injury should be provided to injured research volunteers. However, statistical data of incidence of compensation claims and the rate of awarding them have been rarely reported. Questionnaire surveys were sent to pharmaceutical companies and medical institutions, focusing on industry-initiated ...
Droms Courtney M CM a College of Business , Butler University , Indianapolis , - - 2014
The use of evidence-based medical practice has become the standard for health care decision-making. Thus, it has become increasingly important for medical device manufactures to provide evidence for the efficacy of their products. As new products, services, and solutions are developed, it is important to perform a stakeholder analysis to ...
Leong Poh Kuan PK Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, - - 2013
Snake envenomation is a serious public health threat in many rural areas of Asia and Africa. Antivenom has hitherto been the definite treatment for snake envenomation. Owing to a lack of local production of specific antivenom, most countries in these regions fully depend on foreign supplies of antivenoms. Often, the ...
Wiley Brandon B Mount Sinai School of Medicine, New York, - - 2014
Cardiovascular disease (CVD) is a global epidemic and the largest cause of noncommunicable disease-related death worldwide. The concept of a combination pill, or "polypill," composed of aspirin, antihypertensives, and a statin has been suggested to simplify and improve the prevention and treatment of CVD. Individually, these medications have been shown ...
Datta Soumitra S SS Child & Adolescent Psychiatry, Institute of Psychiatry, King's College London, London, - - 2013
Atypical antipsychotic medications have been the first line of treatment for adolescents with psychosis in the past couple of decades. Till the late 90s, there were very few randomized controlled trials (RCTs) on the treatment of adolescents with psychosis, although a fifth of schizophrenia starts during adolescence. Most of the ...
King Michelle A - - 2013
Background Pharmacists play a pivotal role in optimising medication use which often includes actions to maximise compliance with long-term medication. The best evidence to support medication use is derived from randomised controlled trials (RCTs). It is often assumed that 100 % compliance is required to obtain the outcomes identified in the ...
Mohr J P JP The Neurological Institute, Columbia University Medical Center, New York, NY, - - 2014
The clinical benefit of preventive eradication of unruptured brain arteriovenous malformations remains uncertain. A Randomised trial of Unruptured Brain Arteriovenous malformations (ARUBA) aims to compare the risk of death and symptomatic stroke in patients with an unruptured brain arteriovenous malformation who are allocated to either medical management alone or medical ...
Ho P Michael - - 2013
IMPORTANCE Adherence to cardioprotective medication regimens in the year after hospitalization for acute coronary syndrome (ACS) is poor. OBJECTIVE To test a multifaceted intervention to improve adherence to cardiac medications. DESIGN, SETTING, AND PARTICIPANTS In this randomized clinical trial, 253 patients from 4 Department of Veterans Affairs medical centers located ...
Park Linda G - - 2013
Pharmacologic treatment for secondary prevention of coronary heart disease (CHD) is critical to prevent adverse clinical outcomes. In a randomized controlled trial, we compared antiplatelet and statin adherence among patients with CHD who received: (1) text messages (TM) for medication reminders and education, (2) educational TM only, or (3) No ...
Allen Elizabeth N - - 2013
Accurately characterizing a drug's safety profile is essential. Trial harm and tolerability assessments rely, in part, on participants' reports of medical histories, adverse events (AEs), and concomitant medications. Optimal methods for questioning participants are unclear, but different methods giving different results can undermine meta-analyses. This study compared methods for eliciting ...
Collins Abigail - - 2013
Friedreich ataxia is the most common autosomal recessive ataxia. It is a progressive neurodegenerative disorder, typically with onset before 20 years of age. Signs and symptoms include progressive ataxia, ascending weakness and ascending loss of vibration and joint position senses, pes cavus, scoliosis, cardiomyopathy, and arrhythmias. There are no disease-modifying medications ...
Hanania Nicola A - - 2013
The goals of management of COPD include reducing exposure to risk factors; improving lung function, exercise tolerance, and quality of life; and decreasing exacerbations and mortality. Pharmacologic treatments, such as inhaled β2-agonists, anticholinergics, and inhaled corticosteroids, are widely used to help achieve these goals. In addition to efficacy, medication safety ...
Chang Jason - - 2013
In the Asymptomatic Carotid Artery Stenosis trial (1995), medical management was defined as aspirin in addition to adequate control of comorbidities. Since then, medical management of asymptomatic carotid artery stenosis (CAS) has progressed to include broader use of statins. Our purpose was to review the effect of contemporary medical management ...
Gelijns Annetine C - - 2013
Background: In recent years, there has been growing interest in evaluating the health and economic impact of medical devices. Payers increasingly rely on cost-effectiveness analyses in making their coverage decisions, and are adopting value-based purchasing initiatives. These analytic approaches, however, have been shaped heavily by their use in the pharmaceutical ...
Hirota Tomoya - - 2013
Electroencephalogram-recorded epileptiform activity is common in children with autism spectrum disorder (ASD), even without clinical seizures. A systematic literature search identified 7 randomized, placebo-controlled trials of antiepileptic drugs (AEDs) in ASD (total n = 171), including three of valproate, and one each of lamotrigine, levetiracetam, and topiramate. Meta-analysis revealed no significant difference ...
Hakeem Abdul - - 2013
Controversy persists regarding the management of patients with cryptogenic stroke and patent foramen ovale (PFO). We performed a meta-analysis of randomized controlled trials comparing PFO closure with medical therapy. A prospective protocol was developed and registered using the following data sources: PubMed, Cochrane Register of Controlled Trials, conference proceedings, and ...
van de Laar Rafli - - 2013
Evidence of randomized comparative clinical trials on surgery in recurrent platinum-sensitive ovarian cancer is non-existing. Three randomized phase 3 trials are ongoing. The aim of this study is to evaluate the current opinion of Dutch gynecologists and medical oncologists awaiting the results of these three trials. A 16-item questionnaire was ...
Rossi Gian Paolo - - 2013
A significant proportion of patients treated for acute decompensated heart failure (ADHF) suffer from worsening renal function, which is often associated with medical therapy resistance and poor outcome. In this setting, haemofiltration has been used for more than 30 years, despite inconclusive evidence for its advantages. In the last decade, ...
Feldman M A - - 2013
Persons with intellectual disabilities (ID) are exposed to the same medical interventions as everyone else. Given the unique health profiles of many persons with ID, it cannot be assumed that they will react to medical treatments the same as persons without ID. It is not clear if medical clinical trials ...
Sordo L - - 2013
Institutional monographs/medical textbooks mention seizures as a neurological complication of cocaine, but no systematic reviews (SRs) have been published on this issue. We aimed to conduct a SR of the literature on the relationship between cocaine use and seizures and to summarize the biological plausibility of that relationship. The pathophysiological ...
Federer Andrew E - - 2013
Decision making in health care has evolved substantially over the last century. Up until the late 1970s, medical decision making was predominantly intuitive and anecdotal. It was based on trial and error and involved high levels of problem solving. The 1980s gave way to empirical medicine, which was evidence based ...
Brunkwall Jan - - 2013
Type B aortic dissections continue to be one of the most challenging clinical scenarios confronting vascular surgeons. In the era of open surgery, the therapeutic options were limited to medical management of hypertension and large open thoracoabdominal operations. In the current endovascular era, the operative strategies have become less invasive ...
Alexander John H - - 2013
In ARISTOTLE, apixaban resulted in a 21% reduction in stroke, a 31% reduction in major bleeding, and an 11% reduction in death. However, approval of apixaban was delayed to investigate a statement in the clinical study report that "7.3% of subjects in the apixaban group and 1.2% of subjects in ...
de Wit Hugo A J M - - 2013
The frail elderly populations of nursing homes frequently use drugs and suffer from considerable comorbidities. Medication reviews are intended to support evidence based prescribing and optimise therapy. However, literature is still ambiguous regarding the optimal method and the effects of medication reviews. Innovative computerised systems may support the medication reviews ...
Deitelzweig Steve - - 2013
Abstract Objectives: Based on clinical trials the oral anticoagulants (OACs), apixaban, dabigatran, and rivaroxaban are efficacious for reducing stroke risk for nonvalvular atrial fibrillation (NVAF) patients. Based on the clinical trials, this study evaluated the medical costs for clinical events among NVAF patients ≥75 and <75 years of age treated ...
Landzberg Michael J - - 2013
In our desire to bring harmony to understanding of unexplained pathologies, we tend to relate commonly occurring entities and attempt to demonstrate meaningful association or causality. The foramen ovale is a universally present structure in utero, remaining patent in a substantial proportion of live births and through adulthood. In its ...
Duthoo Wout - - 2013
Objective: We tested the role of dopamine in conflict-induced behavioral adjustments by evaluating the effect of dopaminergic medication on conflict adaptation in Parkinson's disease (PD) patients. Method: Nine PD patients performed a vocal Stroop task on two separate testing occasions: once on their regular medication and once after overnight withdrawal. ...
Choudhury Khushboo - - 2013
The rules for compensation for injury and death in clinical trials have recently been notified. These rules clarify that medical management of all injuries in clinical trials is mandatory and in cases in which injury or death is related to the clinical trial, the subject (or nominee) is entitled to ...
Gwadry-Sridhar Femida H - - 2013
To systematically review the evidence on the impact of interventions to improve medication adherence in adults prescribed antihypertensive medications. An electronic search was undertaken of articles published between 1979 and 2009, without language restriction, that focused on interventions to improve antihypertensive medication adherence among patients (≥18 years) with essential hypertension. ...
Verazza Sara - - 2013
Several studies have examined effects of discontinuing treatment after clinical remission in children with JIA. So far, only methotrexate and tumour necrosis factor α (TNF) inhibitors have been investigated. Overall, the relapse rate after termination of these medications was substantial. However, with the exception of one controlled trial of methotrexate, ...
Moon Sungrim - - 2013
To create a sense inventory of abbreviations and acronyms from clinical texts. The most frequently occurring abbreviations and acronyms from 352 267 dictated clinical notes were used to create a clinical sense inventory. Senses of each abbreviation and acronym were manually annotated from 500 random instances and lexically matched with ...
Jupiter Daniel C - - 2013
Medical literature comes in all shapes and sizes, from animal studies to prospective clinical trials to retrospective chart reviews. In all of these cases, it is worth asking: What are the intellectual goals of the study: description, hypothesis testing, or hypothesis generating? This differentiation can help shape our view of ...
Fuller Jonathan - - 2013
Clinical practice guidelines (CPGs) are an important source of justification for clinical decisions in modern evidence-based practice. Yet, we have given little attention to how they argue their evidence. In particular, how do CPGs argue for treatment with long-term medications that are increasingly prescribed to older patients? APPROACH AND RATIONALE: ...
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