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Signorello Leonarda - - 2014
In this work, was evaluated the stability of Bevacizumab (Avastin®) repackaged in individual 1 mL single-use syringes stored at different conditions. Bevacizumab repackaging in single-use syringes results from the off-label use of the drug as an intravitreal agent in the treatment of retinal diseases. Bevacizumab stability was assessed by assaying ...
Jin Qiao Q MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, - - 2014
A novel amphiphilic ABA-type triblock copolymer poly(ethylene glycol)-b-poly(ethanedithiol-alt-nitrobenzyl)-b-poly(ethylene glycol) (PEG-b-PEDNB-b-PEG) is successfully prepared by sequential thiol-acrylate Michael addition polymerization in one pot. PEG-b-PEDNB-b-PEG is designed to have light-cleavable o-nitrobenzyl linkages and acid-labile β-thiopropionate linkages positioned repeatedly in the main chain of the hydrophobic block. The light and pH dual degradation ...
John Tibin T Center for Complex Systems Studies, Kalamazoo College , Kalamazoo, Michigan , - - 2014
The spirit of systems pharmacology was adopted to study the possible mechanisms of anxiolytic drugs on hippocampal electric patterns. The frequency of the hippocampal theta rhythm increases linearly with the intensity of electrical stimulation to the brainstem. The reduction of mean theta frequency in this paradigm predicts the clinical efficacy ...
Son Suhyun - - 2014
Light-responsive polymeric micelles have emerged as site-specific and time-controlled systems for advanced drug delivery. Spiropyran (SP), a well-known photochromic molecule, was used to initiate the ring-opening, multi-branching polymerization (ROMBP) of glycidol to afford a series of hyperbranched polyglycerols (SP-hb-PG). The micelle assembly and disassembly were induced by an external light ...
Wang Bin B State Key Lab of Pulp and Paper Engineering, South China University of Technology, Guangdong Public Laboratory of Paper Technology and Equipment, Guangzhou, - - 2014
Ethyl cellulose macroinitiator was firstly synthesized by direct acylation of ethyl cellulose with 2-bromopropionyl bromide in a room temperature. And a light-responsive triblock copolymer of ethyl cellulose-g-poly(2-hydroxyethyl methacrylate)-g-poly(spiropyran ether methacrylate) (EC-g-PHEMA-g-PSPMA) was prepared by atom transfer radial polymerization. The amphiphilic structure of the copolymer enabled it to aggregate into spherical ...
Chen Linfeng - - 2014
Controlled release system based on mesoporous silica (MS) nanomaterials has drawn great attention over the past decades due to its potential biomedical applications. Herein, a light-responsive release system based on MS nanoparticles was achieved by adjusting the wetting of the MS surface. At the starting stage, the surface of MS ...
Pasparakis George G 1] Institute of Electronic Structure and Laser (IESL), Foundation for Research and Technology-Hellas (FORTH), PO Box 1527, 71110 Heraklion, Crete, Greece [2] University College London, School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK - - 2014
Light-controlled drug delivery systems constitute an appealing means to direct and confine drug release spatiotemporally at the site of interest with high specificity. However, the utilization of light-activatable systems is hampered by the lack of suitable drug carriers that respond sharply to visible light stimuli at clinically relevant wavelengths. Here, ...
Nagle Samuel M - - 2013
This article examines the challenges associated with making acoustic output measurements at high ultrasound frequencies (>20 MHz) in the context of regulatory considerations contained in the US Food and Drug Administration industry guidance document for diagnostic ultrasound devices. Error sources in the acoustic measurement, including hydrophone calibration and spatial averaging, ...
Vivanco P - - 2013
Exposure of mice to a brief light stimulus during their nocturnal active phase induces several simultaneous behavioral or physiological responses, including circadian rhythm phase shifts, a drop in core body temperature (Tc), suppression of locomotor activity and sleep. Each response is triggered by light, endures for a relatively fixed interval ...
Biviano Angelo B - - 2013
Intravenous ibutilide is used to convert atrial fibrillation (AF) to sinus rhythm (SR) due to its Class III antiarrhythmic mechanisms. However, the effects of ibutilide on local electrograms (EGMs) during AF have not been elucidated. We used EGM analysis techniques to characterize how ibutilide administration changes the frequency, morphology, and ...
Radhakrishnan R - - 2013
We present a fluctuating hydrodynamics approach and a hybrid approach combining fluctuating hydrodynamics with generalized Langevin dynamics to resolve the motion of a nanocarrier when subject to both hydrodynamic interactions and adhesive interactions. Specifically, using these approaches, we compute equilibrium probability distributions at constant temperature as well as velocity autocorrelation ...
Khalil Islam S M - - 2013
Development of targeted drug delivery systems using magnetic microrobots increases the therapeutic indices of drugs. These systems have to be incorporated with precise motion controllers. We demonstrate closed-loop motion control of microrobots under the influence of controlled magnetic fields. Point-to-point motion control of a cluster of iron oxide nanoparticles (diameter ...
Cunha-Filho Marcílio S S - - 2013
In this work, the effects of several technological factors on the stability of β-lapachone (βLAP) in solution and in the solid state were investigated. The effects of relative humidity and light on the stability of βLAP in the solid state were studied. Samples were characterized by liquid chromatography, thermal analysis, ...
Deng Xin - - 2013
The pacemaker activity of mammalian sinoatrial node (SAN) of the heart plays a fundamental role in the integration of vital functions. Studying factors such as drugs that influence pacemaker activity of SAN has its significance. In this study, we isolated sinus venosus, SAN from toads (Bufo gargarizans), and analysed its ...
Zhu Timothy C - - 2012
Photodynamic therapy (PDT) centers on the photochemical interaction of 3 principal components: light, photosensitizer, and oxygen. Over the past 25 years, much has been learned about the basic biophysical mechanisms of PDT, and in the future, a clearer understanding of the physics of PDT will make it possible to translate ...
Melmoth Dean R DR Division of Optometry and Visual Science, Henry Wellcome Laboratories for Visual Sciences, City University London, Northampton Square, London EC1V 0HB, - - 2012
We manipulated the visual information available for grasping to examine what is visually guided when subjects get a precision grip on a common class of object (upright cylinders). In Experiment 1, objects (2 sizes) were placed at different eccentricities to vary the relative proximity to the participant's (n = 6) body of ...
Hayes Phil - - 2012
Abstract The aims of this study were to examine ground contact characteristics, their relationship with race performance, and the time course of any changes in ground contact time during competitive 800 m and 1500 m races. Twenty-two seeded, single-sex middle-distance races totalling 181 runners were filmed at a competitive athletics meeting. Races ...
Hendricks Sharief - - 2012
Abstract The velocity and acceleration at which the ball-carrier or tackler enters the tackle may contribute to winning the contest and prevailing injury free. Velocity and acceleration have been quantified in controlled settings, whereas in match-play it has been subjectively described. The purpose of this study was to determine the ...
Bliznyuk Olesya - - 2012
We investigate the motion of liquid droplets on chemically defined radial wettability gradients. The patterns consist of hydrophobic fluorinated self-assembled monolayers (SAMs) on oxidized silicon substrates. The design comprises a central hydrophobic circle of unpatterned SAMs surrounded by annular regions of radially oriented stripes of alternating wettability, i.e., hydrophilic and ...
Kagawa M - - 2012
We have developed a non-contact heart rate monitoring system for elderly people In bed using two radars placed on the bed base. The system is designed to increase accuracy despite body motion noise and change of body position and sleeping posture In bed. In order to achieve this, we combined ...
Moldrup Morten - - 2012
The dinoflagellate Kryptoperidinium foliaceum possesses one of the largest eyespots among the autotrophic dinoflagellates. Until now they were believed to be negatively phototactic using a non-opsin photopigment. Here we provide evidence that in newly established cultures they are positively phototactic and that the dynamic range of phototaxis is ∼2.5 log ...
Gu C - - 2012
Accurate respiration measurement is crucial in motion-adaptive cancer radiotherapy. Conventional methods for respiration measurement are undesirable because they are either invasive to the patient or do not have sufficient accuracy. In addition, measurement of external respiration signal based on conventional approaches requires close patient contact to the physical device which ...
Iliev Rumen I - - 2012
Harmful events often have a strong physical component-for instance, car accidents, plane crashes, fist fights, and military interventions. Yet there has been very little systematic work on the degree to which physical factors influence our moral judgments about harm. Since physical factors are related to our perception of causality, they ...
Mackenzie Sasho - - 2012
A novel jump-focused (JF) technique of the jump float serve was compared to the conventionally used contact-focused (CF) method. Seven elite male (height: 195 ± 6 cm) and two elite female (height: 181 and 182 cm) volleyball players were videoed at a rate of 60 Hz performing both techniques. Horizontal ...
Trawalter Sophie - - 2012
Many White Americans are concerned about appearing prejudiced. How these concerns affect responses during actual interracial interactions, however, remains understudied. The present work examines stress responses to interracial contact-both in the moment, during interracial interactions (Study 1), and over time as individuals have repeated interracial contact (Study 2). Results of ...
Pobelov Ilya V - - 2012
We describe a new setup for simultaneous measurements of force and current in conductive nanocontacts in a liquid environment with a high sampling rate and resolution. A lab-built current-to-voltage converter allows measurements of the current over seven orders of magnitude. As examples, we studied conductances and mechanical forces upon formation ...
Kankare Elina - - 2012
Contact quotient (CQ), measured by electroglottogram (EGG), is a ratio which illustrates the duration of vocal fold contact during one vocal fold period. In the present study CQ(EGG) was calculated from a sustained vowel phonation in three different phonation types (breathy, normal, pressed) at three amplitude threshold levels (25%, 35%, ...
Forta Nazim Gizem - - 2012
It has not been established whether the smallest perceptible change in the intensity of vibrotactile stimuli depends on the somatosensory channel mediating the sensation. This study investigated intensity difference thresholds for vibration using contact conditions (different frequencies, magnitudes, contact areas, body locations) selected so that perception would be mediated by ...
Guerriero Erica - - 2012
The image shows an integrated graphene voltage amplifier, which paves the way for all-graphene analogue electronics. Signal amplification is obtained by fabricating graphene transistors in which the top gate overlaps with the source and drain contacts. This results in full-channel gating and therefore high transconductance at room temperature. The fabricated ...
Repp Bruno H - - 2012
Studies of phase correction in sensorimotor synchronization often introduce timing perturbations that are unpredictable with regard to direction, magnitude, and position in the stimulus sequence. If participants knew any or all of these parameters in advance, would they be able to anticipate perturbations and thus regain synchrony more quickly? In ...
Djazouli Alim Fatma Zohra - - 2012
The aim of this work is to study the characteristics of the dromedary nervous lobe and determine how the seasons condition its organization. To this end, electron microscopy was performed and examined quantitatively on animals from winter and summer periods. The results show a higher number of cells in the ...
McGreevy Paul D - - 2012
The use of whips by jockeys is an issue. The current study viewed opportunistic high-speed footage of 15 race finishes frame-by-frame to examine the outcomes of arm and wrist actions (nā€Š=ā€Š350) on 40 horses viewed from the left of the field. Any actions fully or partially obscured by infrastructure or ...
Dron Anthony - - 2011
This study provides with original data sets on the physiology of the unicellular diazotrophic cyanobacterium Crocosphaera watsonii WH8501, maintained in continuous culture in conditions of obligate diazotrophy. Cultures were exposed to a 12:12 light-dark regime, representative of what they experience in nature and where growth is expected to be balanced. ...
Garo Florian - - 2011
Shedding light on DNA: A DNA-based light-harvesting antenna has been synthesized. Light is absorbed by π-stacked phenanthrene units and efficiently transferred to a phenanthrene-pyrene exciplex. The whole system is structurally organized by a DNA scaffold. Up to eight phenanthrene units are used for light collection and the intensity of the ...
Dedieu Philippe - - 2011
Mature locomotion in humans is characterized by an anti-phase coordination (moving in opposite directions) between the pelvic and the scapular girdles. This pattern involves a specific relationship between the arm and leg motion is deemed to be most flexible and dynamically efficient. Still, when the arms are involved in another ...
Nowaczewski S - - 2011
Pheasant eggs of different colors differ with regard to physical properties. This study was conducted to ascertain the intensity of infestation by microscopic fungi based on egg color. Settling intensity by microscopic fungi of pheasant egg shells and the content of eggs of different color during a 7-d storage period ...
Gao Peng - - 2011
Zernike phase contrast microscopy is extended and combined with a phase-shifting mechanism to perform quantitative phase measurements of microscopic objects. Dozens of discrete point light sources on a ring are constructed for illumination. For each point light source, three different levels of point-like phase steps are designed, which are alternatively ...
Ibsen Stuart D - - 2011
A previous comparative analysis of normalized click amplitude spectra from a Tursiops truncatus has shown that those frequencies with the lowest click-to-click variability in spectral content were the frequencies the animal paid attention to during target discrimination tasks. In that case, the dolphin only paid attention to the frequency range ...
Kristiansen Ulf R - - 2011
It is well known that airflow in a corrugated pipe can excite whistling at the frequencies of the pipe's longitudinal acoustic modes. This short contribution reports on the results of experiments where a low frequency, oscillating flow with velocity magnitudes of the same order as the airflow has been added. ...
Lee Sang Hern - - 2011
The enhancement of light extraction efficiency is observed when the hole-shape patterned ITO ohmic contact layer and AgIn reflector is adopted in GaN-based flip-chip (FC) light emitting diodes (LEDs). ITO layer (140 nm) and AgIn (200 nm) was deposited on the top of p-GaN by in-line DC sputtering and electron ...
Kerner Boris S - - 2011
Based on simulations of stochastic three-phase and two-phase traffic flow models, we reveal that at a signalized city intersection under small link inflow rates at which a vehicle queue developed during the red phase of the light signal dissolves fully during the green phase, i.e., no traffic gridlock should be ...
Sheean Geoffrey L - - 2011
Quantification in clinical, diagnostic electromyography (EMG) currently includes motor unit action potential (MUAP) analysis and interference pattern analysis. Early efforts to examine the frequency/power spectra of the interference pattern showed modest value but the technique was not developed further. This paper re-examines spectral analysis, extending it into the time-varying domain, ...
Chan Calvin W Y - - 2011
Cross-correlation is often used as the primary technique to compare two biological signals. Cross-correlation is an effective means to measure the synchronization of two signals assuming the relative phases of all frequencies are distributed linearly, that is, a group delay. The group delay assumption imposes an unfavorable restriction on signals ...
Dadesh Khaled M - - 2011
Multispectral photometry is often required to distinguish samples in flow injection analysis and flow cytometry; however, the cost of multiple light detectors, filters, and optical paths contribute to the high cost of multicolor and spectral detection systems. This paper describes frequency division multiplexing (FDM), a simple approach for performing multi-wavelength ...
Ding Yi - - 2011
Phase unwrapping is an important and challenging issue in fringe pattern profilometry. In this Letter we propose an approach to recover absolute phase maps of two fringe patterns with selected frequencies. Compared to existing temporal multiple frequency algorithms, the two frequencies in our proposed algorithm can be high enough and ...
Cardin Velia - - 2011
The principal visual cue to self-motion (egomotion) is optic flow, which is specified in terms of local 2D velocities in the retinal image without reference to depth cues. However, in general, points near the center of expansion of natural flow fields are distant, whereas those in the periphery are closer, ...
Hajnal Alen - - 2011
Historically, the bodily senses have often been regarded as impeccable sources of spatial information and as being the teacher of vision. Here, the authors report that the haptic perception of slope by means of the foot is greatly exaggerated. The exaggeration is present in verbal as well as proprioceptive judgments. ...
Chamoun Georges C - - 2011
We explore whether vortex flows in the wake of a fixed circular cylinder can be stabilized using harmonic forcing. We use Föppl's point vortex model augmented with a harmonic point source-sink mechanism which preserves conservation of mass and leaves the system Hamiltonian. We discover a region of Lyapunov-stable vortex motion ...
Abdala Carolina - - 2011
Scaling symmetry appears to be a fundamental property of the cochlea as evidenced by invariant distortion product otoacoustic emission (DPOAE) phase above ∼1-1.5 kHz when using frequency-scaled stimuli. Below this frequency demarcation, phase steepens. Cochlear scaling and its breaking have been described in the adult cochlea but have not been ...
Dhar Sumitrajit - - 2011
The phase versus frequency function of the distortion product otoacoustic emission (DPOAE) at 2f(1) - f(2) is approximately invariant at frequencies above 1.5 kHz in human subjects when recorded with a constant f(2)/f(1). However, a secular break from this invariance has been observed at lower frequencies where the phase-gradient becomes ...
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