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Chen Horng-Shyang - - 2014
A reverse-biased voltage is applied to either device in the vertical configuration of two light-emitting diodes (LEDs) grown on patterned and flat Si (110) substrates with weak and strong quantum-confined Stark effects (QCSEs), respectively, in the InGaN/GaN quantum wells for independently controlling the applied voltage across and the injection current ...
Guaraldi Pietro P IRCCS Istituto delle Scienze Neurologiche di Bologna , Bologna , Italy - - 2014
Circadian rhythms were recently proposed as a measure of physiological state and prognosis in disorders of consciousness (DOC). So far, melatonin regulation was never assessed in vegetative state (VS). Aim of our research was to investigate the nocturnal melatonin levels and light-induced melatonin suppression in a cohort of VS patients. ...
Wietek Jonas J Institute for Biology, Experimental Biophysics, Humboldt Universität zu Berlin, D-10115 Berlin, - - 2014
The field of optogenetics utilizes channelrhodopsins (ChRs) for light-induced neuronal activation. Optimized tools for cellular inhibition at moderate light levels are however lacking. We found that replacement of E90 in the central gate of ChR with positively charged residues produces chloride-conducting ChRs (ChloCs) with only negligible cation conductance. Molecular dynamics ...
Otsmane Belkacem B The Mediterranean Institute of Neurobiology, Inmed, Marseille, - - 2014
A receptor-ligand interaction can evoke a broad range of biological activities in different cell types depending on receptor identity and cell-type-specific post-receptor signaling intermediates. Here, we show that the TNF family member LIGHT, known to act as a death-triggering factor in motoneurons through LT-βR, can also promote axon outgrowth and ...
Sharkhuu Altanbadralt A Department of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Jeddah, Kingdom of Saudi Arabia; Department of Horticulture and Landscape Architecture, Purdue University, 47907, West Lafayette, Indiana, - - 2014
Glyphosate is a widely applied broad-spectrum systemic herbicide that competitively inhibits the penultimate enzyme, 5-Enolpyruvylshikimate 3-Phosphate Synthase (EPSPS), of the shikimate pathway thereby causing deleterious effects. A glyphosate resistant Arabidopsis mutant (gre1) was isolated and genetic analyses indicated a dysfunctional red (R) and far-red (FR) light receptor, phytochrome B (phyB), ...
Narimatsu Toshio T Laboratory of Retinal Cell Biology; Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, - - 2014
Exposure to light contributes to the development and progression of retinal degenerative diseases. However, the mechanisms underlying light-induced tissue damage are not fully understood. Here, we examined the role of angiotensin II type 1 receptor (AT1R) signaling, which is part of the renin-angiotensin system (RAS), in light-induced retinal damage. Light-exposed ...
Marshak Tal T Unit of Otoneurology, Lin Medical Center, Haifa, - - 2014
To examine the role of intratympanic Dexamethasone (ITD) in the prevention of Cisplatin-induced hearing loss. Prospective randomized controlled clinical trial. Tertiary referral center. Twenty-six patients suffering from a neoplastic disease for which the treatment protocol included Cisplatin were recruited. Prior to each Cisplatin treatment session ITD was injected to the ...
Beiert Thomas T Institute of Physiology I, Life & Brain Center, University of Bonn, - - 2014
Investigation of Gq-signaling with pharmacological agonists of Gq-coupled receptors lacks spatio-temporal precision. The aim of this study was to establish melanopsin, a light-sensitive Gq-coupled receptor, as a new tool for the investigation of spatial and temporal effects of Gq-stimulation on pacemaking in cardiomyocytes at an early developmental stage.Methods and ResultsA ...
Abramian Miganoosh M Graduate School of Biomedical Engineering, University of New South Wales, Sydney, - - 2014
Objective. In this study we investigated the feasibility of quasi-monopolar (QMP) electrical stimulation for retinal implant devices, using a computational model of the retinal ganglion cell layer. Approach. When used with hexagonally arrayed multiple electrodes, QMP stimulation is a hybrid of hexapolar and conventional monopolar stimulus modes. In hexapolar mode, ...
Lindsay Jonathan H JH Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, - - 2014
Ethanol (EtOH) triggers cellular adaptations that induce tolerance in many brain areas, including the suprachiasmatic nucleus (SCN), the site of the master circadian clock. EtOH inhibits light-induced phase shifts in the SCN in vivo and glutamate-induced phase shifts in vitro. The in vitro phase shifts develop acute tolerance to EtOH, ...
Zheng Yan Y Department of Military Hygiene, Faculty of Naval Medicine, Second Military Medical University, 800 Xiang Yin Road, Shanghai, China; Department of Nutrition, Tong Ren Hospital Affiliated to Shanghai JiaoTong University School of Medicine, 1111 Xian Xia Road, Shanghai, China. Electronic address: - - 2014
Low-dose dexamethasone has been widely used for the prevention of nausea and vomiting after chemotherapy and surgical procedures and to treat motion sickness due to its minimal adverse effects, but the mechanisms underlying its anti-motion sickness effects are poorly understood. Previous studies have demonstrated that the endocannabinoid system is suppressed ...
Gu Xiao-Jing XJ State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China ; University of Chinese Academy of Sciences, Beijing, - - 2014
The idea of retinal and ex-retinal sources of saccadic suppression has long been established in previous studies. However, how they are implemented in local circuit remains unknown. Researchers have suggested that saccadic suppression was probably achieved by contrast gain control, but this possibility has never been directly tested. In this ...
Takamizawa Akifumi - - 2014
In this study, incoherent light with a spectral linewidth of 7 nm and 140 mW of power was generated from a laser diode (LD) into which incoherent light emitted from a superluminescent diode was injected with 2.7 mW of power. The spectral linewidth of the light from the LD was broadened to 12 nm ...
Cheron G G Laboratory of Electrophysiology, Université de Mons, 7000 Mons, Belgium; Laboratory of Neurophysiology and Movement Biomechanics, CP601, ULB Neurosciences Institut, Université Libre de Bruxelles, 1070 Brussels, Belgium. Electronic address: - - 2014
Purkinje cell (PC) firing represents the sole output from the cerebellar cortex onto the deep cerebellar and vestibular nuclei. Here, we explored the different modes of PC firing in alert mice by extracellular recording. We confirm the existence of a tonic and/or bursting and quiescent modes corresponding to UP and ...
Chung Seok Jong SJ Department of Neurology (SJC), Yonsei University College of Medicine, Seoul, Korea; Department of Neurology (S-HP, J-SK, SWO, HJK, JHP, YEH), Seoul National University Bundang Hospital, Seongnam-si, Korea; and Department of Neurology (S-HP, J-SK), Seoul National University College of Medicine, Seoul, - - 2014
: A 43-year-old man with a high-grade glioma involving the cerebellar nodulus showed a near-complete suppression of periodic alternating nystagmus (PAN) in the lateral decubitus position to either side. This positional modulation of PAN is consistent with suppression of the velocity storage mechanism by head position changes (tilt dumping) and ...
Jones Rebecca S RS Dominick P. Purpura Department of Neuroscience and Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, The Rose F. Kennedy Center, Bronx, New York - - 2014
Retinal ganglion cells (RGCs) receive glutamatergic input from bipolar cells through NMDA- and AMPA-type glutamate receptors. Both GluA2-containing, Ca(2+)-impermeable AMPA receptors (CI-AMPARs) and GluA2-lacking, Ca(2+)-permeable AMPA receptors (CP-AMPARs) contribute to light-evoked responses in ON RGCs; however, specific roles for each subtype are not well understood. Here, we present evidence that ...
Janson Jolanda J Carl von Ossietzky University, Oldenburg, - - 2014
The attentional blink (AB) is a deficit in conscious perception of the second of two targets if it follows the first within 200-500 msec. The AB phenomenon has been linked to pretarget oscillatory alpha activity. However, this is based on paradigms that use a rapid serial visual presentation (RSVP) stimulus ...
Trenado Carlos C Department of Neurology and Neurophysiology, Albert-Ludwigs-University Freiburg, - - 2014
Modern attempts to improve human performance focus on stochastic resonance (SR). SR is a phenomenon in non-linear systems characterized by a response increase of the system induced by a particular level of input noise. Recently, we reported that an optimum level of 0-15 Hz Gaussian noise applied to the human ...
Chung Charles Y L CY The School of Optometry and Vision Science, The University of New South Wales, Kensington NSW, - - 2014
In the present study we addressed whether the processing of global form and motion was dependent on visual awareness. Continuous flash suppression (CFS) was used to suppress from awareness global dot motion (GDM) and Glass pattern stimuli. We quantified the minimum time taken for both pattern types to break suppression ...
Iliopoulos Fivos F MPI for Human Cognitive and Brain - - 2013
While noise is usually considered to be harmful for signal detection and information transmission, Stochastic Resonance (SR) describes the counterintuitive phenomenon of noise enhancing the detection and transmission of weak input signals. In mammalian sensory systems SR related phenomena may arise both in the peripheral and the central nervous system. ...
Gannon Robert L RL Department of Biology, Valdosta State University, Valdosta, Georgia, USA. Electronic address: - - 2013
Many physiological systems in mammals are linked to the body's master circadian rhythm in the sleep/wake cycle and dysfunctions in this rhythm has been associated with neurological diseases such as major depression, Alzheimer's Disease and schizophrenia. There is some evidence that nicotinic cholinergic input to the master circadian pacemaker, the ...
Newman Ehren L EL Center for Memory and Brain, Department of Psychology, Boston University, Boston, Massachusetts 02215 and Graduate Program, Division of Biological Sciences and Center for Neural Circuits and Behavior, Department of Neurosciences, University of California, San Diego, La Jolla, California - - 2013
Large-scale neural activation dynamics in the hippocampal-entorhinal circuit local field potential, observable as theta and gamma rhythms and coupling between these rhythms, is predictive of encoding success. Behavioral studies show that systemic administration of muscarinic acetylcholine receptor antagonists selectively impairs encoding, suggesting that they may also disrupt the coupling between ...
Rea Adam C AC Department of Chemistry, University of Georgia, Athens, GA 30602, - - 2013
Serotonin (5-HT) is a neuromodulator involved in regulating mood, appetite, memory, learning, pain, and establishment of left-right (LR) asymmetry in embryonic development. To explore the role of 5-HT in physiology, we have created two forms of "caged" 5-HT, BHQ-O-5HT and BHQ-N-5HT. When exposed to 365 or 740 nm light, BHQ-O-5HT releases ...
Wang Wei - - 2013
Preeclampsia, a prevalent hypertensive disorder of pregnancy, is believed to be secondary to uteroplacental ischemia. Accumulating evidence indicates that hypoxia-independent mediators, including inflammatory cytokines and growth factors, are associated with preeclampsia, but it is unclear whether these signals directly contribute to placental damage and disease development in vivo. We report ...
Yadollahpour Ali A Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, - - 2013
The present study was aimed to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on kindling-induced synaptic potentiation and to study the effect of frequency and coil shape on rTMS effectiveness. Seizures were induced in rats by perforant path stimulation in a rapid kindling manner (12 stimulations/day). rTMS was ...
Schintu Selene - - 2013
Rightward prism adaptation has been shown to ameliorate visuospatial biases in right brain-damaged patients with neglect, and a single session of prism adaptation can lead to improvements that last up to several hours. Leftward prism adaptation in neurologically healthy individuals induces neglect-like biases in visuospatial tasks. The duration of these ...
Woodruff Michael L ML From the Department of Integrative Biology and Physiology, UCLA, Los Angeles, California - - 2014
Previous experiments have indicated that growth factor receptor-bound protein 14 (Grb14) may modulate rod photoreceptor cGMP-gated channels by decreasing channel affinity for cGMP; however, the function of Grb14 in rod physiology is not known. In this study, we examined the role of Grb14 by recording electrical responses from rods in ...
Quaedflieg Conny Wem - - 2013
Remifentanil (Ultiva(®)) is a potent ultra-short acting mu-opioid receptor agonist used for perioperative pain treatment and anaesthesia. So far, it is not known how sensitive the cognitive processing of auditory perception elicited by the mismatch negativity (MMN) paradigm is to opioids. The present exploratory study investigated how the opioid remifentanil ...
Tsuruma Kazuhiro - - 2013
Adipose tissue stromal vascular fraction contains mesenchymal stem cells, which show protective effects when administered to damaged tissues, mainly through secreted trophic factors. We examined the protective effects of adipose-derived stem cells (ASCs) and ASC-conditioned medium (ASC-CM) against retinal damage and identified the neuroprotective factors in ASC-CM. ASCs and mature ...
Keshavarz Behrang - - 2013
Illusory self-motion (known as vection) describes the sensation of ego-motion in the absence of physical movement. Vection typically occurs in stationary observers being exposed to visual information that suggest self-motion (e.g. simulators, virtual reality). In the present study, we tested whether sensory integration of visual information triggers vection: Participants (N=13) ...
Estey Paula - - 2013
Switched on! A tetra-stable switch has been synthesized in two steps, utilizing photoresponsive isoindolinone moieties. Sequential E-Z isomerization induced by 365 nm light results in a propeller switching action that is reversible using 458 nm light, acid, and high temperature.
Popova E - - 2013
The effects of dopamine receptor blockade by sulpiride (D2-class antagonist) and sulpiride plus SCH 23390 (D1-class antagonist) on the V - log I function of the electroretinographic (ERG) b- and d-waves were investigated in light-adapted frog eyes. Sulpiride significantly decreased the absolute sensitivity of the b- and d-waves. The amplitude of the ...
Tang Xiaobing - - 2013
We present successful fabrication of single n-ZnO/p-AlGaN heterojunction nanowires with excellent optoelectronic properties. Due to the formation of high-quality interfacial structure, heterojunction nanowire showed a diodelike rectification behavior and an electroluminescence (EL) ultraviolet (UV) emission centered at 394 nm from a single nanowire was observed when the injection current is ...
Park Seunghye - - 2013
The development of highly inducible promoters is critical for designing effective transformation systems for transgenic analyses. In this study, we investigated the promoter of the light-inducible protein gene (LIP) of the marine alga Dunaliella sp. LIPs are homologs of the early light-induced proteins (ELIPs) of Arabidopsis thaliana. DNA sequence analysis ...
Cagnan Hayriye H 1 Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, West Wing Level 6, OX3 9DU, Oxford, - - 2013
High frequency deep brain stimulation of the thalamus can help ameliorate severe essential tremor. Here we explore how the efficacy, efficiency and selectivity of thalamic deep brain stimulation might be improved in this condition. We started from the hypothesis that the effects of electrical stimulation on essential tremor may be ...
Chang Mun Young - - 2013
The amplitude of distortion-product otoacoustic emission (DPOAE) is suppressed in one ear when the contralateral ear is subjected to sound stimulation. Contralateral suppression of DPOAE is the phenomenon resulted by the efferent cochlear innervation on the outer hair cells via medial olivocochlear bundle (MOCB) and inferior vestibular nerve. We assumed ...
Souza J A - - 2013
We study the all-optical control of the quantum fluctuations of a light beam via a combination of single-atom cavity quantum electrodynamics (CQED) and electromagnetically induced transparency (EIT). Specifically, the EIT control field is used to tune the CQED transition frequencies in and out of resonance with the probe light. In ...
Théveniau Nicolas - - 2013
The spatiotemporal features of walking in toddlers are known to be related to the level of maturation of the central nervous system. However, previous studies did not assess whether there could be an effect of clothes on the acquisition of walking. In this study, it was hypothesized that clothes modify ...
Jones Kenneth A KA 1] Lundbeck Research USA Inc., Paramus, New Jersey, USA. - - 2013
Melanopsin, expressed in a subset of retinal ganglion cells, mediates behavioral adaptation to ambient light and other non-image-forming photic responses. This has raised the possibility that pharmacological manipulation of melanopsin can modulate several central nervous system responses, including photophobia, sleep, circadian rhythms and neuroendocrine function. Here we describe the identification ...
Gouveneaux Anaïd - - 2013
Tomopteris helgolandica Greeff 1879 (Tomopteridae) is a transparent holoplanktonic polychaete that can emit a bright light. In this work, we investigated the emission pattern and control of this deep-sea worm's luminescence. Potassium chloride depolarisation applied on anesthetised specimens triggered a maximal yellow light emission from specific parapodial sites, suggesting that ...
Walther Andreas - - 2013
In performing arts venues, the spectra of direct and reflected sound at a receiving location differ, due to seat dip effect, diffusive and absorptive surfaces, and source directivity. This paper examines the influence of differing lead and lag spectral contents on echo suppression threshold. The results indicate, that for a ...
Lin John Y JY Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093-0647, USA. - - 2013
Optogenetic techniques provide effective ways of manipulating the functions of selected neurons with light. In the current study, we engineered an optogenetic technique that directly inhibits neurotransmitter release. We used a genetically encoded singlet oxygen generator, miniSOG, to conduct chromophore assisted light inactivation (CALI) of synaptic proteins. Fusions of miniSOG ...
Hoeberichts Frank A - - 2013
The fungal elicitor cryptogein triggers a light-dependent hypersensitive response (HR) in tobacco (Nicotiana tabacum). To assess the effect of light on this non-host resistance in more detail, we studied various aspects of the response under dark and light conditions using the tobacco-cryptogein experimental system. Here, we show that light drastically ...
Kai Kazuki - - 2013
To characterize the neural elements involved in the higher-order control of spontaneous walking in insects, we recorded extracellular spike activity in the protocerebrum of freely walking crickets (Gryllus bimaculatus). Locomotor behavior was simultaneously recorded using a newly developed motion tracking system. We focused on spike units that altered their firing ...
Bashford James A - - 2013
Three experiments examined the intelligibility enhancement produced when noise bands flank high intensity narrowband speech. Enhancement was unaffected by noise gating (experiment 1), ruling out peripheral adaptation as a source, and was also unaffected by interaural decorrelation of noise bands flanking diotic speech (experiment 2), indicating that enhancement occurs prior ...
Kirking Bryan C - - 2013
Purpose: Quantify changes in the flexion - extension neutral zone of the intervertebral disc with injections of increasing genipin concentration.
Methods: Bovine motion segments were treated with varying concentrations of genipin using bilateral injections of constant volume. After overnight static compression loading of the treated segments, anterior- posterior offset loading was ...
Church Michael W MW Department of Otolaryngology & Head Neck Surgery, Wayne State University School of Medicine, Detroit, MI 48201, USA. - - 2013
'Ecstasy' or 3,4-methylenedioxy-N-methamphetamine (MDMA) is an amphetamine abused for its euphoric, empathogenic, hallucinatory, and stimulant effects. It is also used to treat certain psychiatric disorders. Common settings for Ecstasy use are nightclubs and "rave" parties where participants consume MDMA and dance to loud music. One concern with the club setting ...
van de Werken Maan - - 2013
Exposure to light at night increases alertness, but light at night (especially short-wavelength light) also disrupts nocturnal physiology. Such disruption is thought to underlie medical problems for which shiftworkers have increased risk. In 33 male subjects we investigated whether short-wavelength attenuated polychromatic white light (<530 nm filtered out) at night preserves ...
Sivarao Digavalli V - - 2013
Patients with schizophrenia show marked deficits in processing sensory inputs including a reduction in the generation and synchronization of 40 Hz gamma oscillations in response to steady-state auditory stimulation. Such deficits are not readily demonstrable at other input frequencies. Acute administration of NMDA antagonists to healthy human subjects or laboratory ...
Isago Hitomi - - 2013
BACKGROUND: Numerous rodent models of photoreceptor degeneration have been developed for the study of visual function. However, no viable model has been established in a species that is more closely related to Homo sapiens. Here, we present a rabbit model of monocular photoreceptor degeneration. METHODS: We tested 2 chemicals, verteporfin ...
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