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Hamada Toshiyuki T Applied Molecular-Imaging Physics, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan; Ishida Group of Clock Gene, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, - - 2014
p53 protein plays a role for control of cell proliferation and the induction of apoptosis in normal cells. However, its role in the circadian rhythms that control many physiological functions including locomotor behavior remains unknown. The present study examined the locomotors activity rhythms of mice which have homozygous mutations of ...
Bittman Eric L EL Department of Biology and Program in Neuroscience and Behavior, University of Massachusetts, Amherst, MA, - - 2014
The duper mutation in Syrian hamsters shortens the free-running period (τDD) of locomotor activity by approximately 1 h when expressed on the wild-type background and by 2 h on the tau mutant background ("super duper"). In either case, duper markedly amplifies the phase response curve (PRC) of the light pulse. ...
Balan Ranjini R Dept. of Biotechnology, Indian Institute of Technology Madras, Chennai, 600036, - - 2014
We report for the first time that the endogenous, pseudo-steady-state, specific intracellular levels of the hydroxyl radical (si-OH) oscillate in an ultradian fashion (model system: the microalga, Chlorella vulgaris), and also characterize the various rhythm parameters. The ultradian rhythm in the endogenous levels of the si-OH occurred with an approximately ...
Bussi Ivana L IL Laboratorio de Cronobiología, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes/CONICET, R. S. Peña 352, B1876BXD, Bernal, Buenos Aires, - - 2014
Duration discrimination within the seconds-to-minutes range, known as interval timing, involves the interaction of cortico-striatal circuits via dopaminergic-glutamatergic pathways. Besides interval timing, most (if not all) organisms exhibit circadian rhythms in physiological, metabolic and behavioral functions with periods close to 24 h. We have previously reported that both circadian disruption and ...
Fonken Laura K LK Department of Neuroscience, Wexner Medical Center, The Ohio State University, Columbus, OH 43210 - - 2014
Most organisms display endogenously produced ∼f24 h fluctuations in physiology and behavior, termed circadian rhythms. Circadian rhythms are driven by a transcriptional-translational feedback loop that is hierarchically expressed throughout the brain and body, with the suprachiasmatic nucleus of the hypothalamus serving as the master circadian oscillator at the top of ...
Arco Roger M RM Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Apdo. Postal 70-360 México D.F. 04510, - - 2014
Fluid-suspended microorganisms have evolved different swimming and feeding strategies in order to cope with an environment dominated by viscous effects. For instance, ciliated organisms rely on the collective motion of flexible appendages to move and feed. By performing a non-reciprocal motion, flexible filaments can produce a net propulsive force, or ...
Yadav Pankaj P Chronobiology Laboratory, Evolutionary and Organismal Biology Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, 560064, Karnataka, - - 2014
Circadian clocks time developmental stages of fruit flies Drosophila melanogaster, while light/dark (LD) cycles delimit emergence of adults, conceding only during the "allowed gate". Previous studies have revealed that time-to-emergence can be altered by mutations in the core clock gene period (per), or by altering the length of LD cycles. ...
Pattanayak Gopal G Department of Molecular Genetics and Cell Biology, Institute for Genomics and Systems Biology, University of Chicago, 900 E 57th Street, Chicago, IL 60637, United - - 2014
Cyanobacteria possess the simplest known circadian clock, which presents a unique opportunity to study how rhythms are generated and how input signals from the environment reset the clock time. The kaiABC locus forms the core of the oscillator, and the remarkable ability to reconstitute oscillations using purified KaiABC proteins has ...
Paditsaeree Kampanart K Faculty of Sports Science, Chulalongkorn - - 2014
Elastic tubing attached to a barbell has been reported to enhance strength and power to a greater extent as compared to conventional barbells. The aim of this study was to investigate the effect of the additional elastic tubing to a barbell during a clean pull on peak power (PP), peak ...
Pilorz Violetta V Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, - - 2014
Many aspects of mammalian physiology are driven through the coordinated action of internal circadian clocks. Clock speed (period) and phase (temporal alignment) are fundamental to an organism's ability to synchronize with its environment. In humans, lifestyles that disturb these clocks, such as shift work, increase the incidence of diseases such ...
Loudon Andrew S I AS Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK. Electronic address: - - 2014
Severe noise can cause permanent hearing damage. A recent study now shows that the capacity to recover from noise damage varies with time of day, driven by circadian clock control of a nerve growth factor (BDNF) in the inner ear.
Haudum Anita A Department of Sport Science and Kinesiology, University of Salzburg, Salzburg, Austria; Doppler Laboratory "Biomechanics in Skiing", Rifer Schlossallee 49, 5400 Hallein/Rif, Salzburg, Austria. Electronic address: - - 2014
This paper explores the effect of goal-oriented external perturbations created by elastic tubes attached to the hip and ankles on lower limb joint variability and hip-knee and knee-ankle coordination variability during running. Kinematics of ten healthy male runners were analysed prior to and following a 7-week tube running intervention while ...
Israel Yonatan Y Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, - - 2014
A quantum polarized light microscope using entangled NOON states with N=2 and N=3 is shown to provide phase supersensitivity beyond the standard quantum limit. We constructed such a microscope and imaged birefringent objects at a very low light level of 50 photons per pixel, where shot noise seriously hampers classical ...
Duan Yanmin - - 2014
This Letter describes an intracavity pumped optical parametric oscillator (OPO) based on noncritical phase matching RbTiOPO<sub>4</sub> (RTP) crystal driven by a laser diode end-pumping acousto-optic Q-switched Nd:YVO<sub>4</sub> laser. Simultaneous efficient signal light at 1.6 μm and idler light at 3.1 μm outputs were obtained. At an incident pump power of 10.5 W and ...
Meltser Inna I Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, - - 2014
Noise-induced hearing loss (NIHL) is a debilitating sensory impairment affecting 10%-15% of the population, caused primarily through damage to the sensory hair cells or to the auditory neurons. Once lost, these never regenerate [1], and no effective drugs are available [2, 3]. Emerging evidence points toward an important contribution of ...
Shamsi Nurulaini Abu NA Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, 5005 South Australia, - - 2014
The time of day at which meals are consumed is known to impact on behaviour as well as physiological systems. In this study we investigated the behavioural and physiological effects of restricting access to food to the light or dark period in mice maintained on either long or short photoperiods. ...
Kösem Anne A INSERM, U992, Cognitive Neuroimaging Unit, F-91191 Gif/Yvette, France; CEA, DSV/I2BM, NeuroSpin Center, F-91191 Gif/Yvette, France; Univ Paris-Sud, Cognitive Neuroimaging Unit, F-91191 Gif/Yvette, - - 2014
Time perception is a critical component of conscious experience. To be in synchrony with the environment, the brain must not only deal with differences in the speed of light and sound but also with its computational and neural transmission delays. Here, we asked whether the brain could actively compensate for ...
Paredes Juan Fernando JF Department of Physiology, University of Murcia, Regional Campus of International Excellence "Campus Mare Nostrum" , Murcia , Spain - - 2014
This research aimed at investigating circadian rhythm expression of key genes involved in lipid metabolism in the liver of a teleost fish (Sparus aurata), and their synchronisation to different light-dark (L-D) and feeding cycles. To this end, 90 gilthead sea bream were kept in 12:12 h (light:dark, LD, lights on at ...
Chen Chih-Rong - - 2014
While a fundamental Gaussian light beam can form stably a spatial soliton in certain self-focusing medium, a single-wave topologically integer-n-charge vortex light beam cannot. It breaks up into 2n filaments due to symmetry breaking and azimuthal instability, in which every azimuthal section of a π phase range from a soliton ...
Archer G S GS Department of Animal Science and Center for Animal Welfare, University of California-Davis, One Shields Ave, Davis - - 2014
Light stimulation during incubation can affect the behavior, health, and performance of poultry posthatch. However, there has been relatively little work systematically assessing the pattern of light stimulation needed to produce these effects or the mechanism underlying them. We conducted 2 experiments to assess the effects of duration and onset ...
Sorek Michal M The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel. Electronic address: - - 2014
To date, the association and synchronization between two organismal circadian clocks ticking in parallel as part of a meta-organism (termed a symbiotic association), have rarely been investigated. Reef-building corals exhibit complex rhythmic responses to diurnal, lunar, and annual changes. Understanding circadian, circatidal, and annual regulation in reef-building corals is complicated ...
Wu Lisa L *Department of Clinical Biochemistry, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, - - 2014
Circadian rhythms are a hallmark of living organisms, observable in all walks of life from primitive bacteria to highly complex humans. They are believed to have evolved to co-ordinate the timing of biological and behavioural processes to the changing environmental needs brought on by the progression of day and night ...
Takekata Hiroki H Graduate School of Science, Osaka City University, Osaka, - - 2014
Whether the circatidal rhythm is generated by a machinery common to the circadian clock is one of the important and interesting questions in chronobiology. The mangrove cricket Apteronemobius asahinai shows a circatidal rhythm generating active and inactive phases and a circadian rhythm modifying the circatidal rhythm by inhibiting activity during ...
Gooch Van D VD Division of Science and Mathematics, University of Minnesota-Morris, Morris, MN, - - 2014
The fungus Neurospora crassa constitutes an important model system extensively used in chronobiology. Several studies have addressed how environmental cues, such as light, can reset or synchronize a circadian system. By means of an optimized firefly luciferase reporter gene and a controllable lighting system, we show that Neurospora can display ...
Ramkisoensing Ashna A Laboratory for Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the - - 2014
The suprachiasmatic nucleus (SCN) adapts to both the external light-dark (LD) cycle and seasonal changes in day length. In short photoperiods, single-cell activity patterns are tightly synchronized (i.e., in phase); in long photoperiods, these patterns are relatively dispersed, causing lower amplitude rhythms. The limit cycle oscillator has been used to ...
Gooch Van D VD Division of Science and Mathematics, University of Minnesota-Morris, Morris, MN, - - 2014
The role of the frq gene in the Neurospora crassa circadian rhythm has been widely studied, but technical limitations have hindered a thorough analysis of frq circadian expression waveform. Through our experiments, we have shown an improved precision in defining Neurospora's circadian rhythm kinetics using a codon optimized firefly luciferase ...
Simoni Alekos A School of Biological and Chemical Science, Queen Mary, University of London, London E1 4NS, - - 2014
Circadian clocks attune the physiology of virtually all living organisms to the diurnal cycles of their environments. In metazoan animals, multiple sensory input pathways have been linked to clock synchronization with the environmental cycle (entrainment). Extrinsic entrainment cues include light and temperature. We show that (12-hour:12-hour) cycles of vibration and ...
Fifel Karim K Inserm, U846, Stem Cell and Brain Research Institute, Bron, France ; Université de Lyon, Lyon 1, UMR-S 846, Lyon, - - 2014
Disturbances of the daily sleep/wake cycle are common non-motor symptoms of Parkinson's disease (PD). However, the impact of dopamine (DA) depletion on circadian rhythms in PD patients or non-human primate (NHP) models of the disorder have not been investigated. We evaluated alterations of circadian rhythms in NHP following MPTP lesion ...
Najjar Raymond P RP Department of Chronobiology, Inserm U846, Stem Cell and Brain Research Institute, Bron, France ; University of Lyon, Claude Bernard Lyon 1, Villeurbanne, - - 2014
The deterioration of sleep in the older population is a prevalent feature that contributes to a decrease in quality of life. Inappropriate entrainment of the circadian clock by light is considered to contribute to the alteration of sleep structure and circadian rhythms in the elderly. The present study investigates the ...
Magalhães Moraes Maria Nathália de Carvalho MN Department of Physiology, Institute of Biosciences, University of São Paulo, São Paulo, - - 2014
Light-dark cycles are considered important cues to entrain biological clocks. A feedback loop of clock gene transcription and translation is the molecular basis underlying the mechanism of both central and peripheral clocks. Xenopus laevis embryonic melanophores respond to light with melanin granule dispersion, response possibly mediated by the photopigment melanopsin. ...
Gawronski Piotr P Leibniz Institute of Plant Genetics and Crop Plant Research - - 2014
Viable circadian clocks help organisms to synchronize their development with daily and seasonal changes, thereby providing both evolutionary fitness and advantage from an agricultural perspective. High-resolution mapping approach combined with mutant analysis revealed a cereal ortholog of Arabidopsis thaliana LUX ARRHYTHMO/ PHYTOCLOCK 1 (LUX/ PCL1) as a promising candidate for ...
Ben-Moshe Zohar Z George S. Wise Faculty of Life Sciences, Department of Neurobiology, Tel-Aviv University, Tel-Aviv 69978, Israel, Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel, Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany and Raymond and Beverly Sackler School of Physics and Astronomy, Tel-Aviv University, Tel-Aviv 69978, - - 2014
Light constitutes a primary signal whereby endogenous circadian clocks are synchronized ('entrained') with the day/night cycle. The molecular mechanisms underlying this vital process are known to require gene activation, yet are incompletely understood. Here, the light-induced transcriptome in the zebrafish central clock organ, the pineal gland, was characterized by messenger ...
Tataroglu Ozgur O Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United - - 2014
Circadian rhythms have a profound influence on most bodily functions: from metabolism to complex behaviors. They ensure that all these biological processes are optimized with the time-of-day. They are generated by endogenous molecular oscillators that have a period that closely, but not exactly, matches day length. These molecular clocks are ...
Richter Diethelm W DW Department of Neuro- and Sensory Physiology, University of Göttingen, Göttingen, Germany; and Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, - - 2014
The cellular and circuit mechanisms generating the rhythm of breathing in mammals have been under intense investigation for decades. Here, we try to integrate the key discoveries into an updated description of the basic neural processes generating respiratory rhythm under in vivo conditions.
Du Pré Bastiaan C BC Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The - - 2014
Circadian rhythms are of major importance in mammalian physiology and disease. In this review, we give an overview of the present knowledge on origination of circadian rhythms. We discuss the development of both master and peripheral clocks and compare the origination of circadian rhythms in utero and in vitro.
Paul Matthew J MJ Department of Neurology, University of Massachusetts Medical School, , Worcester, MA 01655, - - 2014
A number of field and laboratory studies have shown that the social environment influences daily rhythms in numerous species. However, underlying mechanisms, including the circadian system's role, are not known. Obstacles to this research have been the inability to track and objectively analyse rhythms of individual animals housed together. Here, ...
Launay Jacques J Department of Experimental Psychology, University of Oxford Oxford, - - 2014
Why do some people have problems "feeling the beat"? Here we investigate participants with congenital impairments in musical rhythm perception and production. A web-based version of the Montreal Battery of Evaluation of Amusia was used to screen for difficulties with rhythmic processing in a large sample and we identified three ...
Facco Enrico E a University of Padua and Italian Center for Clinical and Experimental Hypnosis , Turin , - - 2014
Abstract To evaluate the effect of hypnotically induced amusia for rhythm (a condition in which individuals are unable to recognize melodies or rhythms) on mismatch negativity (MMN), 5 highly (HH) and 5 poorly (LH) hypnotizable nonmusician volunteers underwent MMN recording before and during a hypnotic suggestion for amusia. MMN amplitude ...
Spröwitz Alexander T AT Biorobotics Laboratory, École Polytechnique Fédérale de Lausanne Lausanne, - - 2014
In this work we research the role of body dynamics in the complexity of kinematic patterns in a quadruped robot with compliant legs. Two gait patterns, lateral sequence walk and trot, along with leg length control patterns of different complexity were implemented in a modular, feed-forward locomotion controller. The controller ...
Apthorp Deborah D Research School of Psychology, Australian National University, Canberra, Australian Capital Territory, Australia; School of Psychology, University of Wollongong, Wollongong, New South Wales, - - 2014
Illusory self-motion ('vection') in depth is strongly enhanced when horizontal/vertical simulated viewpoint oscillation is added to optic flow inducing displays; a similar effect is found for simulated viewpoint jitter. The underlying cause of these oscillation and jitter advantages for vection is still unknown. Here we investigate the possibility that perceived ...
Perkin Elizabeth K EK Leibniz Institute of Freshwater Ecology and Inland Fisheries , Berlin , Germany ; Institute of Biology, Freie Universität Berlin , Berlin , - - 2014
Artificial light is gaining attention as a potential stressor to aquatic ecosystems. Artificial lights located near streams increase light levels experienced by stream invertebrates and we hypothesized light would depress night drift rates. We also hypothesized that the effect of light on drift rates would decrease over time as the ...
Ozturk Nuri N UNC-CH, United - - 2013
Cryptochrome (CRY) is the primary circadian photoreceptor in Drosophila. Upon light absorption, dCRY undergoes a conformational change that enables it to bind to Timeless (dTIM), as well as to two different E3 ligases that ubiquitylate dTIM and dCRY, respectively, resulting in their proteolysis and re-setting the phase of the circadian ...
Hubbert Laila L Clinical Department of Cardiology at the Heart Center, University Hospital of Linkoping, Linkoping, Sweden; Department of Medicine & Health, Linkoping University, Linkoping, - - 2013
Mechanical circulatory support technology is continually improving. However, adverse complications do occur with devastating consequences, for example, pump thrombosis that may develop in several parts of the pump system. The aim of this study was to design an experimental clot/thrombosis model to register and analyze acoustic signals from the left ...
de Carvalho Magalhães Moraes Maria Nathália MN Department of Physiology, Institute of Biosciences, University of São Paulo, São Paulo, - - 2013
Light-dark cycles are considered important cues to entrain biological clocks. A feedback loop of clock gene transcription and translation is the molecular basis underlying the mechanism of both central and peripheral clocks. Xenopus laevis embryonic melanophores respond to light with melanin granule dispersion, response possibly mediated by the photopigment melanopsin. ...
Hasegawa Yoshihiko Y Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, , Tokyo 113-0033, - - 2014
Circadian oscillation provides selection advantages through synchronization to the daylight cycle. However, a reliable clock must be designed through two conflicting properties: entrainability to synchronize internal time with periodic stimuli such as sunlight, and regularity to oscillate with a precise period. These two aspects do not easily coexist, because better ...
Owen Megan A MA Applied Animal Ecology, Institute for Conservation Research, San Diego Zoo Global, San Diego, - - 2013
Anthropogenic noise has become a pervasive feature of both marine and terrestrial habitats worldwide. While a comprehensive understanding of the biologically significant impacts of noise on wildlife is lacking, concerns regarding its influence persist. Noise is also a common feature in the zoological setting, and much can be learned regarding ...
Polidarová Lenka L 1Institute of Physiology, v.v.i., Academy of Sciences of the Czech - - 2013
Colonic morphology and function change significantly during ontogenesis. In mammals, many colonic physiological functions are temporally controlled by the circadian clock in the colon, which is entrained by the central circadian clock in the suprachiasmatic nuclei (SCN). The aim of this present study was to ascertain when and how the ...
Forbes-Stovall Jennifer J Department of Biology, Western Kentucky University, 1906 College Heights Blvd., Bowling Green, KY 42101, - - 2013
The unicellular green alga Chlamydomonas reinhardtii has long served as model organism for studies on the circadian clock. This clock is present in all eukaryotes and some prokaryotes allowing them to anticipate and take advantage of the daily oscillations in the environment. Although much is known about the circadian clock ...
McMahon Douglas G DG Department of Biological Sciences, Vanderbilt University, Nashville, TN, - - 2013
The retinal circadian system represents a unique structure. It contains a complete circadian system and thus the retina represents an ideal model to study fundamental questions of how neural circadian systems are organized and what signaling pathways are used to maintain synchrony of the different structures in the system. In ...
Keijzer Henry H Department of Clinical Chemistry and Hematology, Rijnstate Hospital, Arnhem, The Netherlands; Governor Kremers Centre, University Maastricht, The Netherlands. Electronic address: - - 2013
Treatment of circadian rhythm sleep disorders (CRSD) may include light therapy, chronotherapy and melatonin. Exogenous melatonin is increasingly being used in patients with insomnia or CRSD. Although pharmacopoeias and the European food safety authority (EFSA) recommend administering melatonin 1-2 h before desired bedtime, several studies have shown that melatonin is not always ...
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