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Results 301 - 350 of 991
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Hoffmann Anika - - 2010
Clathrin triskelia consist of three heavy chains and three light chains (LCs). Green fluorescent protein (GFP)-tagged LCs are widely utilized to follow the dynamics of clathrin in living cells, but whether they reflect faithfully the behavior of clathrin triskelia in cells has not been investigated yet thoroughly. As an alternative ...
Previte Joseph P - - 2011
In the vertebrate spinal cord, a neural circuit called the central pattern generator produces the basic locomotory rhythm. Short and long distance intersegmental connections serve to maintain coordination along the length of the body. As a way of examining the influence of such connections, we consider a model of a ...
Dispenzieri Angela A Hematology, Mayo Clinic, Rochester, MN 55905, USA. - - 2010
Monoclonal gammopathy of undetermined significance (MGUS) is defined by expression of heavy-chain immunoglobulin (IgH) and is the precursor lesion for 80% of cases of multiple myeloma. The remaining 20% are characterised by absence of IgH expression; we aimed to assess prevalence of a corresponding precursor entity, light-chain MGUS. We used ...
Kostareli E - - 2010
The study of intraclonal diversification (ID) in immunoglobulin (IG) genes offers valuable insight into the role of ongoing interactions with antigen in lymphomagenesis. We recently showed that ID in the IG heavy chain genes of patients with chronic lymphocytic leukemia (CLL) was generally limited; however, intense ID was evident in ...
Tracy Jennifer A JA Peripheral Neuropathy Research Laboratory, Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, - - 2010
Peripheral neuropathy in primary (AL) amyloidosis is usually lower-limb predominant, length-dependent, symmetrical, and affects small (pain and autonomic) fibers, as much or more than large fibers. We report a patient with stepwise progressive, multiple upper limb mononeuropathies that were due to nerve biopsy-proven primary amyloidosis (lambda light chain), with no ...
Frankel Adam S - - 2010
Between 2004 and 2006, large groups of melon-headed whales were recorded off the Big Island of Hawai'i. No other odontocete species were sighted in these groups. Recordings contained echolocation clicks, burst-pulse sounds, and whistles. Echolocation clicks typically contained energy beginning at 13 kHz and continued strongly to the frequency cutoff ...
Croghan Naomi B H - - 2010
In an anechoic chamber the minimum audible angle (MAA) was measured in seven normal-hearing adults for a narrow band of noise centered at 4000 Hz (target). In the absence of an interfering stimulus, the average MAA was 2.1°. When a low-frequency interferer (a narrow band of noise centered at 500 ...
Honma Riko - - 2010
Quantitative assay for serum free light chains (sFLC) is reported as a useful test for diagnosis and monitoring of patients with nonsecretory multiple myeloma (NSM). We performed serial sFLC assays in a patient with NSM with light chain cast nephropathy (LCCN) and light chain deposition disease (LCDD). After 3 cycles ...
Pavan M - - 2010
About one in five people with multiple myeloma produce only light chains. Patients with lambda light chain disease have a three times worse prognosis than kappa light chain disease. We report a case of lambda light chain deposition disease in a 35-year-old female who presented with acute renal failure requiring ...
Wadbua Paweena - - 2010
This study is the first to report on the fabrication and properties of electrospun scaffolds derived from separated light-chain fibroin and heavy-chain fibroin, two major proteins of silk fibroin. Among seven different extraction conditions, which were commonly used to extract fibroin from cocoons of Bombyx mori, only Ajisawa's reagent and ...
Urakami Naohito - - 2010
We have performed Brownian dynamics simulations in order to investigate the formation of a pseudopolyrotaxane (PPRX) with cyclodextrins (CDs) and a polymer chain and the development of orientational order between PPRXs. The coarse-grained model is used to model the CDs and the polymer chain. In our simulations, we observe the ...
Rokszin Alice - - 2010
Motion perception is the process through which one gathers information on the dynamic visual world, in terms of the speed and movement direction of its elements. Motion sensation takes place from the retinal light sensitive elements, through the visual thalamus, the primary and higher visual cortices. In the present review ...
Oğmen Haluk - - 2010
Geometry is closely linked to visual perception; yet, very little is known about the geometry of visual processing beyond early retinotopic organization. We present a variety of perceptual phenomena showing that a retinotopic representation is neither sufficient nor necessary to support form perception. We discuss the popular "object files" concept ...
Briand Pierre-Yves - - 2010
BACKGROUND: The Freelite system for nephelometric or turbidimetric measurement of serum free light chains (FLCs) has been available since 2001. It has been valuable for the management of patients with oligosecretory myeloma, light chain myeloma and AL amyloidosis. However, there are several limitations of the method. The goal of this ...
Sing Charles E - - 2010
Biological flows at the microscopic scale are important for the transport of nutrients, locomotion, and differentiation. Here, we present a unique approach for creating controlled, surface-induced flows inspired by a ubiquitous biological system, cilia. Our design is based on a collection of self-assembled colloidal rotors that "walk" along surfaces in ...
Zidar Nina - - 2010
Light chain deposition disease (LCDD) is a rare disorder associated with a clonal proliferation of plasma cells, which synthesize abnormal monoclonal immunoglobulin light chains. It is characterized by systemic deposition of light chains in various organs, with the kidneys being most commonly affected. There have been few reports of isolated ...
Barr N B - - 2009
A molecular protocol using a hemi-nested polymerase chain reaction (PCR) of the internal transcribed spacer region 2 (ITS2) is reported for the diagnosis of light brown apple moth, Epiphyas postvittana (Walker) (Lepidoptera: Tortricidae), in California. This protocol distinguishes the light brown apple moth from other moths in California based on ...
Sharma Vikram - - 2009
Antibodies with nucleophilic or catalytic properties often have these characteristics encoded in their germ line genes. Because hydrolytic activity has been reported to be associated with light chain V regions, we have begun an analysis of germ line light chain proteins that could be the basis for affinity maturation into ...
de Alba Campomanes Alejandra G - - 2009
PURPOSE: The purpose of this study was to report the occurrence of crystalline keratopathy and of orbital infiltrative disease resulting from crystal-storing histiocytosis (CSH) in a patient with monoclonal gammopathy of undetermined significance. METHODS: The authors conducted a review of a medical record and immunohistopathologic studies. RESULTS: A 66-year-old man ...
Feeney M Patrick - - 2009
OBJECTIVE: Recent studies have suggested the potential of wideband energy reflectance (ER) for the assessment of middle ear disorders. The purpose of this study was to examine the use of wideband ER in the evaluation of an ossicular discontinuity and its repair in human cadaver temporal bones. DESIGN: ER measurements ...
Tate Jill - - 2009
Serum free light chain (FLC) assay is an important advance in the diagnosis and monitoring of monoclonal light chain diseases and a complementary test to serum protein electrophoresis and immunofixation. Immunoturbidimetric and immunonephelometric assays for serum FLC are available on routine chemistry analysers and can detect FLC down to approximately ...
Montialoux Hélène - - 2009
We report the case of a 77-year-old man referred for jaundice and diagnosed with intrahepatic light chain deposit as primary manifestation of a kappa light chain multiple myeloma. Jaundice is a very rare way of presentation for myeloma. In our observation, diagnosis was made by liver biopsy, which found light ...
Rho Lisa - - 2009
Light chain deposition disease (LCDD) is a rare condition characterized by extracellular light chain deposition in tissues. Patients commonly have an underlying plasma cell dyscrasia, and produce excess levels of monoclonal light chains. Renal involvement is the most common clinical manifestation. Rarely, light chains are deposited in the lung. We ...
Shaheen Saad P - - 2009
BACKGROUND: A nephelometric assay for identifying free light chains (FLC) of immunoglobulin in serum is commercially available. Although this assay is not specific for monoclonal FLC, an abnormal kappa/lambda ratio is thought to presumptively identify monoclonal FLCs. It has been proposed that serum FLC assays can replace urine immunofixation electrophoresis ...
Toshchevikov V - - 2009
We propose a microscopic theory of light-induced deformation of side-chain azobenzene polymers taking into account the internal structure of polymer chains. Our theory is based on the fact that interaction of chromophores with the polarized light leads to the orientation anisotropy of azobenzene macromolecules which is accompanied by the appearance ...
Ouellette David - - 2009
Monoclonal antibodies in liquid formulation undergo nonenzymatic hydrolysis when stored at 5 degrees C for extended periods. This hydrolysis is enhanced at extreme pH and high temperature. In this study we discover that iron in the presence of histidine also enhanced cleavage of human immunoglobulin gamma (IgG) molecules containing a ...
Ramazanzadeh Barat Ali - - 2009
OBJECTIVE: This study evaluated Sodium Fluoride mouth rinse effects on elastic properties of different elastomeric chains. STUDY DESIGN: In this in vitro experiment, two orthodontic chains were tested. In the first group, they were stored in artificial saliva for the entire duration, and in the second group they were immersed ...
Poshusta Tanya L - - 2009
BACKGROUND: The amyloidoses are protein misfolding diseases characterized by the deposition of amyloid that leads to cell death and tissue degeneration. In immunoglobulin light chain amyloidosis (AL), each patient has a unique monoclonal immunoglobulin light chain (LC) that forms amyloid deposits. Somatic mutations in AL LCs make these proteins less ...
Si Wenjie W School of Electrical Engineering and Automation, Tianjin University, Tianjin, P. R. China. - - 2009
The internal frequencies of chain network of FHN neurons include two different frequencies, namely, the intrinsic and Canard frequency. When the frequency of external stimuli approaches to the values of these two frequencies, signal processing in the chain will be enhanced. In traditional medical of Chinese acupuncture, signals evoked by ...
Kamei Takashi - - 2009
We demonstrate significant photoresponsivity in aqueous media to visible light of pseudo-oligonucleotides possessing 4-(dimethylamino)azobenzene (4-DMAzo) side chains. The spectrum of the 4-DMAzo moiety during 436 nm light irradiation at pH >9 was clearly different from that of the all (E)-form, indicating the presence of the (Z)-form. Thermal (Z)-to-(E) recovery isomerization ...
Allen R A - - 2008
Two separate but related studies were conducted regarding management of Anopheles quadrimaculatus larval populations in commercial rice fields near Cleveland, MS, in 2004. Study 1 was to evaluate the effectiveness of 2 treatments of aerially applied ultra-low volume applications of Bacillus thuringiensis var. israelensis (Bti) against An. quadrimaculatus larvae in ...
Kaplan Batia - - 2009
Immunoglobulin light chain amyloidosis (AL) and non-amyloid light chain deposition disease (NALCDD) are different forms of protein aggregation disorders accompanied by a monoclonal gammopathy. Monoclonal free light chains (FLCs) are precursors of the pathological light chain tissue deposits that are fibrillar in AL and granular in NALCDD. However, direct biochemical ...
Dispenzieri A - - 2009
The serum immunoglobulin-free light chain (FLC) assay measures levels of free kappa and lambda immunoglobulin light chains. There are three major indications for the FLC assay in the evaluation and management of multiple myeloma and related plasma cell disorders (PCD). In the context of screening, the serum FLC assay in ...
Dhingra Swaran - - 2008
BACKGROUND Unlike synthetic pesticides, azadirachtin-based neem pesticides are environmentally friendly and are well known for their diverse pest control properties. Their use is, however, limited by the instability of azadirachtin, necessitating application at short intervals. The efficacy of relatively stable tetrahydroazadirachtin-A, therefore, needed to be established under field conditions. Azadirachtin-A ...
Briem Daniela - - 2009
A subset of German function verbs can be used either in a full, concrete, 'heavy' ("take a computer") or in a more metaphorical, abstract or 'light' meaning ("take a shower", no actual 'taking' involved). The present magnetoencephalographic (MEG) study explored whether this subset of 'light' verbs is represented in distinct ...
Ferse Bernhard - - 2008
The gelation process of poly-(N-isopropylacrylamide)-clay nanocomposite hydrogels (PNIPAAm-clay NC gels) was investigated by dynamic and static light scattering (DLS and SLS), as well as by fluorescence correlation spectroscopy (FCS). The photopolymerization method chosen for the radical polymerizing system ensured that, when the irradiation is removed, the reaction stopped immediately. Experiments ...
Smith Kyle S KS McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. - - 2009
In recent years the ventral pallidum has become a focus of great research interest as a mechanism of reward and incentive motivation. As a major output for limbic signals, the ventral pallidum was once associated primarily with motor functions rather than regarded as a reward structure in its own right. ...
Niset J - - 2008
We devise a scheme that protects quantum coherent states of light from probabilistic losses, thus achieving the first continuous-variable quantum erasure-correcting code. If the occurrence of erasures can be probed, then the decoder enables, in principle, a perfect recovery of the original light states. Otherwise, if supplemented with postselection based ...
Scheyer Torsten M - - 2008
Although we are starting to understand the molecular basis of shell development based on the study of cryptodires, basic comparative ontogenetic data for the other major clade of living turtle, the pleurodires, are largely missing. Herein, the developmental and phylogenetic relation between the bony shell and endoskeleton of Pleurodira are ...
Hu Dongmei - - 2008
Light chain amyloidoses arise from the overproduction and abnormal deposition of the immunoglobulin light chain in various organs. LEN is the variable domain of an immunoglobulin light chain originally isolated from the urine of a patient suffering from multiple myeloma, with no sign of renal dysfunction or amyloidosis. LEN was ...
Trout J D - - 2008
Credibility is a cherished currency in science, but its cues can be counterfeit. A novel series of experiments by Weisberg and her colleagues show that non-expert consumers of behavioral explanations assign greater standing to explanations that contain neuroscientific details, even if these details provide no additional explanatory value. Here, we ...
Ling Yan - - 2008
Although theory suggests that CEOs who engage in transformational leadership should have a positive effect on firm performance, most empirical examinations using data drawn from larger firms have failed to find support for this linkage. Given that the organizational complexity associated with larger firms has been viewed as a central ...
Lang Gui-Hua L - - 2008
A case study involving an improvised pipe bomb with a drilled fuse hole is presented. This case study and its accompanying research details drill bit use and/or nonuse indicators. These indicators are then further classified to develop relevant conclusion criteria. These criteria are: (1) trace deposits in the form of ...
Watanabe Takashi - - 2008
Functional mapping of the lateral lemniscus and the superior olivary complex as part of the auditory pathway was accomplished for the first time in mice in vivo using manganese-enhanced MRI (2.35T, 3D FLASH, 117 microm isotropic resolution). These and other auditory centers in the brainstem presented with pronounced signal enhancements ...
Bond Charles F - - 2008
C. F. Bond and B. M. DePaulo reported a quantitative synthesis of individual differences in judging deception. Here, the authors respond to a pair of commentaries on this synthesis: a statistical critique by T. D. Pigott and M. J. Wu and a narrative reaction by M. O'Sullivan. In response to ...
Mariani Christian - - 2008
A novel method to set highly accurate initial conditions has been designed in the context of shock tube experiments for the Richtmyer-Meshkov instability study. Stereolithography has been used to design the membrane supports which initially materialize the gaseous interface. The visualizations of both heavy-light and light-heavy sinusoidal interfaces were carried ...
Arneth B - - 2009
BACKGROUND: So far, an inflammation of the central nervous system (CNS) is diagnosed by immunoglobulin measurement in cerebrospinal fluid (CSF) and serum as well as by determination of the oligoclonal bands. With the free kappa and lambda light chains, new markers to diagnose intrathecal synthesis are available. METHODS: In addition ...
Rossi Federico - - 2008
The effects of the anionic surfactant sodium dodecyl sulfate (SDS) on the spatio-temporal and temporal dynamics of the ferroin-catalyzed Belousov-Zhabotinsky (BZ) reaction have been studied over a wide surfactant concentration range. For the first time, investigations were performed also for unstirred systems. The presence of SDS in the reaction mixture ...
Preuss Thomas G - - 2008
Bioaccumulation is an important aspect for the fate and effects of xenobiotics in the environment. In this study we used a radiolabeled nonylphenol isomer to investigate the bioconcentration in Daphnia magna at different ages. Apart from the total radioactivity we measured the metabolism of p353-NP in D. magna, to calculate ...
Demoucron Matthias - - 2008
Players of bowed instruments commonly separate notes by changing the direction of the bow motion ("bow changes"). The separation can be made more or less pronounced (detache - portato - martellato). In contrast, long notes, requiring more than a full bow stroke, are played by making the bow changes as ...
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