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Gee Lucy - - 2014
Subthalamic deep brain stimulation (STN-DBS) is a highly effective treatment for motor symptoms of Parkinson disease (PD). As motor symptom treatment improves, non-motor symptoms of PD are highlighted. Currently, 65% to 80% of PD patients suffer from chronic pain. Significant decreases are found in sensory thresholds of PD patients compared ...
Wang Shaolan S Department of Genetics and Molecular Biology, School of Medicine, Xi'an Jiaotong University, Xi'an, - - 2014
Oxidative stress is considered as a major cause of light-induced retinal neurodegeneration. The protective role of 17β-estradiol (βE2) in neurodegenerative disorders is well known, but its underlying mechanism remains unclear. Here, we utilized a light-induced retinal damage model to explore the mechanism by which βE2 exerts its neuroprotective effect. Adult ...
Gall Andrew J AJ Department of Psychology and Neuroscience Program Michigan State University East Lansing, MI USA. Electronic address: - - 2014
The intergeniculate leaflet (IGL) plays an important role in the entrainment of circadian rhythms and the mediation of acute behavioral responses to light (i.e., masking). Recently, we reported that IGL lesions in diurnal grass rats result in a reversal in masking responses to light as compared to controls. Here, we ...
Benova T T Slovak Academy of Sciences, Institute for Heart Research, Bratislava, Slovak - - 2014
Melatonin in addition to regulation of circadian rhythm exhibits antihypertensive, free radicals scavenging and antiarrhythmic effects as we have shown recently. While melatonin deficiency and lower omega-3 index observed in pts suffering from CHD and hypertension as well as in SHR can contribute to disease progression and pro-arrhythmia. Continuous light ...
Langel Jennifer J Neuroscience Program, Michigan State University, East Lansing, - - 2014
Light not only entrains the circadian system but also has acute effects on physiology and behavior, a phenomenon known as masking. Behavioral masking responses to bright light differ in diurnal and nocturnal species, such that light increases arousal in the former and decreases it in the latter. Comparisons made within ...
Riede Tobias T Department of Biology and National Center for Voice and Speech, University of Utah, Salt Lake City, Utah 84112 - - 2014
Small units of production, or modules, can be effective building blocks of more complex motor behaviors. Recording underlying movements of vocal production in awake and spontaneously behaving male Sprague Dawley rats interacting with a female, I tested whether the underlying movements of ultrasonic calls can be described by modules. Movements ...
Deats Sean P SP Department of Psychology, Michigan State University, East Lansing, MI 48824, - - 2014
Light has profound effects on mood, as exemplified by seasonal affective disorder (SAD) and the beneficial effects of bright light therapy. However, the underlying neural pathways through which light regulates mood are not well understood. Our previous work has developed the diurnal grass rat, Arvicanthis niloticus, as an animal model ...
Eftaxiopoulou Theofano T Department of Bioengineering and The Royal British Legion Centre for Blast Injury Studies at Imperial College London, South Kensington Campus, SW7 2AZ; The Royal British Legion Centre for Blast Injury Studies at Imperial College London, South Kensington Campus, SW7 2AZ. Electronic address: - - 2014
The aim of this work was to test a method for measuring the gait of rats with sufficient sensitivity to detect subtle locomotor changes due to pathology, injury and recovery. The gait of female Sprague-Dawley rats was assessed using an optical motion tracking system and the DigiGait™ imaging system during ...
Dip Fernando D FD Training Centre and Experimental Surgery José de San Martín Clinical Hospital, Buenos Aires, Argentina, - - 2014
The unique property of sodium fluorescein has made it ideal for use in medical applications such as diagnostic ophthalmology and intravenous angiography. It is mainly excreted via the renal system and although extensively used in these diagnostic applications, it has not been widely used to aid in the visualization of ...
Soo-Chan Kim - - 2014
Locomotion involves an integration of vision, proprioception, and vestibular information. The parieto-insular vestibular cortex is known to affect the supra-spinal rhythm generators, and the vestibular system regulates anti-gravity muscle tone of the lower leg in the same side to maintain an upright posture through the extra-pyramidal track. To demonstrate the ...
Shinder Michael Elliott ME Dartmouth - - 2014
Head-direction (HD) cells respond when an animal faces a particular direction and form the basis for the animal's perceived directional heading. When an animal moves through its environment, accurate updating of the HD signal is required to reflect the current heading, but the cells still maintain a representation of HD ...
Herzog Linnea L Wellesley - - 2014
Electrophysiology in primates has implicated long-range neural coherence as a potential mechanism for enhancing sensory detection. To test whether local synchronization and long-range neural coherence supports detection performance in rats, we recorded local field potentials (LFPs) in frontal and parietal cortex while rats performed an auditory detection task. We observed ...
Flo Ana A Departament de Fisiologia. Facultat de Farmàcia, Universitat de Barcelona; Departament de Farmàcia i Tecnologia Farmacèutica. Facultat de Farmàcia, Universitat de Barcelona, Barcelona, - - 2014
Circadian rhythms are present in most functions of living beings. We have demonstrated the presence of circadian rhythms in skin variables (Transepidermal Water Loss, TEWL; Stratum Corneum Hydration, SCH and skin temperature) in hairless rats under different environmental conditions of light and temperature. Circadian rhythms in TEWL and SCH showed ...
Polycarpou Irene - - 2014
The aim of this study is to investigate the impact of respiratory motion correction and spatial resolution on lesion detectability in PET as a function of lesion size and tracer uptake. Real respiratory signals describing different breathing types are combined with a motion model formed from real dynamic MR data ...
Nakatsuka Hiroki H Department of Brain Science and Engineering, Graduate school of Life Science and Systems Engineering, Kitakyusyu, Fukuoka 808-0196, - - 2014
Circadian rhythm affects neuronal plasticity. Consistent with this, some forms of synaptic long-term potentiation (LTP) are modulated by the light/dark cycle (LD cycle). For example, this type of modulation is observed in hippocampal slices. In rodents, which are nocturnal, LTP is usually facilitated in the dark phase, but the rat ...
Willis Gregory L GL Neurosciences Section, The Bronowski Institute of Behavioural Neuroscience, Coliban Medical Centre, 19 Jennings Street, Kyneton, Victoria 3444, - - 2014
Critical analysis of recent research suggesting that light pollution causes Parkinson's disease (PD) reveals that such a hypothesis is unsustainable in the context of therapeutic use of light in treating various neuropsychiatric conditions. Reinterpretation of their findings suggests that retinal damage caused by prolonged light exposure may have contributed to ...
Hindley Emma L EL School of Psychology, Cardiff University, Cardiff CF10 3AT, United - - 2014
The retrosplenial cortex supports navigation, with one role thought to be the integration of different spatial cue types. This hypothesis was extended by examining the integration of nonspatial cues. Rats with lesions in either the dysgranular subregion of retrosplenial cortex (area 30) or lesions in both the granular and dysgranular ...
Romeo Stefania S Biotechnological and Applied Clinical Sciences Department, University of L'Aquila, 67100 L'Aquila, - - 2014
Recent data indicates that prolonged bright light exposure of rats induces production of neuromelanin and reduction of tyrosine hydroxylase positive neurons in the substantia nigra. This effect was the result of direct light reaching the substantia nigra and not due to alteration of circadian rhythms. Here, we measured the spectrum ...
Tasaka Atsushi A Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima, - - 2014
The effect of skin resection on joint contracture was determined by comparing the first measurement of range of motion after cast removal and the second measurement after the skin resection. This study aimed to verify that both the joint movement during the measurement and skin affect range of motion. [Subjects] ...
Aslani Shilan S Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho Braga, Portugal ; ICVS/3B's - PT Government Associate Laboratory Braga/Guimarães, - - 2014
Chronic mild stress (CMS) protocols are widely used to create animal models of depression. Despite this, the inconsistencies in the reported effects may be indicative of crucial differences in methodology. Here, we considered the time of the diurnal cycle in which stressors are applied as a possible relevant temporal variable ...
Long Lauren L LL Department of Psychology, University of Connecticut, Storrs, Connecticut, United States of - - 2014
Theta (6-12 Hz) rhythmicity in the local field potential (LFP) reflects a clocking mechanism that brings physically isolated neurons together in time, allowing for the integration and segregation of distributed cell assemblies. Variation in the theta signal has been linked to locomotor speed, sensorimotor integration as well as cognitive processing. ...
Guo Yi Y Department of Biomedical Engineering, New Jersey Institute of Technology Newark, NJ, - - 2014
In search of a solution to the long standing problems encountered in traditional brain computer interfaces (BCI), the lateral descending tracts of the spinal cord present an alternative site for taping into the volitional motor signals. Due to the convergence of the cortical outputs into a final common pathway in ...
Guo Cindy X CX Department of Optometry and Vision Science, University of Auckland, Auckland, New Zealand ; New Zealand National Eye Centre, University of Auckland, Auckland, New - - 2014
Changes in connexin expression are associated with many pathological conditions seen in animal models and in humans. We hypothesized that gap junctions are important mediators in tissue dysfunction and injury processes in the retina, and therefore, we investigated the pattern of connexin protein expression in the light-damaged albino rat eye. ...
Wren Melissa A MA Departments of Comparative Medicine, Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana, USA. - - 2014
The suprachiasmatic nucleus is synchronized by the light:dark cycle and is the master biologic clock that serves as a pacemaker to regulate circadian rhythms. We explored the hypothesis that spectral transmittance (tint) of light through caging alters circadian rhythms of endocrine and metabolic plasma constituents in nonpigmented Sprague-Dawley rats. Rats ...
Lee Kyung J KJ Department of Brain and Cognitive Sciences, Seoul National University Seoul, South - - 2014
Learning theories categorize learning systems into elemental and contextual systems, the former being processed by non-hippocampal regions and the latter being processed in the hippocampus. A set of complex stimuli such as a visual background is often considered a contextual stimulus and simple sensory stimuli such as pure tone and ...
Ashkenazy-Frolinger Tal T Department of Zoology, Tel-Aviv University, Ramat-Aviv, 69978, Tel Aviv, - - 2013
Circadian rhythms are strongly associated with affective disorders and recent studies have suggested utilization of diurnal rodents as model animal for circadian rhythms-related domains of these disorders. Previous work with the diurnal fat sand rat and Nile grass rat demonstrated that short photoperiod conditions result in behavioral changes including anxiety- ...
Repová-Bednárová K K Department of Pathophysiology, School of Medicine, Comenius University, Bratislava, Slovak Republic. - - 2013
Chronic continuous light exposure leads to melatonin deficiency along with complex neurohumoral activation resulting in hypertension development in rats. The aim of this study was to show, whether continuous light induces fibrotic rebuilding of the aorta and whether the treatment with melatonin or angiotensin converting enzyme inhibitor captopril can prevent ...
Bielefeld Eric C - - 2013
Objective: Isoflurane anesthesia can have significant effects on processing of sounds at the peripheral and central levels, manifesting in changes in auditory-evoked potentials. The current study tested whether duration of isoflurane anesthesia changes thresholds, amplitudes, and latencies of the auditory brainstem response (ABR). Design: The study tested ABRs in a ...
Shin Jung-A - - 2013
The nature and intensity of visual stimuli have changed in recent years because of television and other dynamic light sources. Although light stimuli accompanied by contrast and strength changes are thought to have an influence on visual system development, little information is available on the effects of dynamic light stimuli ...
Bungart Brittani L - - 2013
Alzheimer's disease (AD) is the sixth leading cause of age-related death with no effective intervention yet available. Our previous studies have demonstrated the potential efficacy of Low Level Laser Therapy (LLLT) in AD cell models by mitigating amyloid-β peptide (Aβ)-induced oxidative stress and inflammation. However, the penetration depth of light ...
Fontanetti P A - - 2013
Tooth eruption is a multifactorial process in which bone tissue plays a prevailing role. In this study we evaluated the bone overlying the developing tooth germ and the degree of tooth eruption of the first mandibular molar in pups born to mothers subjected to constant light during pregnancy. Pregnant rats ...
Klejbor I I Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland. - - 2013
There have been no reports on how the light-dark changes determine the locomotor activity of animals in the group of high reactivity (HR) and low reactivity (LR). In the present study we have compared selected parameters of the locomotor activity of the HR and the LR groups of the laboratory ...
Xu Yue - - 2013
Previous studies have shown activation of cyclic AMP response element-binding protein (CREB) family is involved in the retinal ganglion cells (RGCs) protection. However, the function of cyclic AMP response element modulator-1 (CREM-1), one member of the CREB family, is still with limited acquaintance. To investigate whether CREM-1 is involved in ...
Xu Wei - - 2013
Abstract Purpose: Mesenchymal stem cells (MSCs) are currently considered to be modulators of repair in various tissues. After MSC transplant, photoreceptor rescue has been demonstrated in models of retinal degeneration. Herein, we evaluate the roles of MSCs in modulating the host reaction and photoreceptor preservation in rats suffering from light-induced ...
Buhusi Catalin V - - 2013
Interruptions and unfamiliar events (distracters) during a timed signal disrupt (delay) timing in humans and other animals. We hypothesized that repeated exposure to a stimulus may reduce its subsequent time-disrupting properties. To test this hypothesis rats were trained in a reversed peak-interval (RPI) procedure, in which dark timing trials were ...
Charles Yann Philippe - - 2013
Facet supplementation stabilizes after facetectomy and undercutting laminectomy. It is indicated in degenerative spondylolisthesis with moderate disc degeneration and dynamic stenosis. To determine the influence of an auxiliary facet system (AFS) on the instrumented disc, adjacent levels' discs, and facet joints and to compare it with fusion. Finite element study. ...
Panouillères M - - 2013
The cerebellum is critically involved in the adaptation mechanisms that maintain the accuracy of goal-directed acts such as saccadic eye movements. Two categories of saccades, each relying on different adaptation mechanisms, are defined: reactive (externally triggered) saccades and voluntary (internally triggered) saccades. The contribution of the medio-posterior part of the ...
Barak Orly - - 2013
Daily rhythms are heavily influenced by light in two major ways. One is through photic entrainment of a circadian clock, and the other is through a more direct process, referred to as masking. Whereas entraining effects of photic stimuli are quite similar in nocturnal and diurnal species, masking is very ...
Laffon Eric - - 2013
The aim of this work was to assess the variability of total lesion glycolysis (TLG) measurements in lung cancer patients, obtained with fixed percentages of the maximum standardized uptake value (SUVmax) thresholds. Thirteen lesions (10 patients) were analyzed in 10 successive 2.5-min frames of an (18)F-FDG PET dynamic acquisition obtained ...
Shin Sang-Jin - - 2013
Our purpose was to investigate the effect of supraspinatus tendon tear combined with anterior capsulolabral injury on glenohumeral joint biomechanics and to identify which structures should be repaired when both pathologic conditions are present. Eight cadaveric shoulders were tested on a custom system. Five conditions were tested: intact supraspinatus full-thickness ...
Shiramatsu Tomoyo I - - 2013
In the auditory cortex, onset activities have been extensively investigated as a cortical representation of sound information such as sound frequency. Yet, less attention has been paid to date to steady-state activities following the onset activities. In this study, we used machine learning to investigate whether steady-state activities in the ...
Dougal G - - 2013
BACKGROUND: Recent research has shown that low-level light therapy (LLLT) using 1072 nm infrared light is effective in reducing the duration of herpes simplex labialis (HSL) episodes and enhancing the healing process. METHODS: This was a prospective, randomized, placebo-controlled, clinical trial to evaluate the efficacy of a 1072 nm light-emitting diode device ...
Arrant Andrew E - - 2013
The light/dark (LD) test is a commonly used rodent test of unconditioned anxiety-like behavior that is based on an approach/avoidance conflict between the drive to explore novel areas and an aversion to brightly lit, open spaces. We used the LD test to investigate developmental differences in behavior between adolescent (postnatal ...
Natalini Paola M - - 2013
The present study shows the selective light-dependent distribution of 1,2-diacylglycerol kinase epsilon (DAGKε) in photoreceptor cells from bovine and albino rat retina. Immunofluorescence microscopy in isolated rod outer segments from bleached bovine retinas (BBROS) revealed a higher DAGKε signal than that found in rod outer segments from dark-adapted bovine retinas ...
Cohen Bernard B Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, Brooklyn 10029-6574, USA. - - 2013
Vasovagal responses (VVRs) are characterized by transient drops in blood pressure (BP) and heart rate (HR) and increased amplitude of low-frequency oscillations in the Mayer wave frequency range. Typical VVRs were induced in anesthetized, male, Long-Evans rats by sinusoidal galvanic vestibular stimulation (sGVS). VVRs were also produced by single sinusoids ...
Chen Hui H Department of Ophthalmology and University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, - - 2013
Light-induced retinal degeneration (LIRD) in albino rats causes apoptotic photoreceptor cell death. Ceramide is a second messenger for apoptosis. We tested whether increases in ceramide mediate photoreceptor apoptosis in LIRD and if inhibition of ceramide synthesis protects the retina. Sprague-Dawley rats were exposed to 2,700 lux white light for 6 ...
Tao Ye - - 2013
To elucidate the underlying pathologic mechanism of congenital stationary night blindness (CSNB) by examining the characteristics of electrical signal transmission within the inner retinal circuit after Cacna1f gene mutation. Retinas isolated from the spontaneous Cacna1f mutant rats or wild-type rats were placed into a recording chamber, with the ganglion cell ...
Dauchy Robert T RT Department of Structural & Cellular Biology, Tulane University School of Medicine, Tulane, LA, USA. - - 2013
Light is potent in circadian, neuroendocrine, and neurobehavioral regulation, thereby having profound influence on the health and wellbeing of all mammals, including laboratory animals. We hypothesized that the spectral quality of light transmitted through colored compared with clear standard rodent cages alters circadian production of melatonin and temporal coordination of ...
Shih Yen-Yu I - - 2013
The present study aimed to quantify retinal and choroidal blood flow (BF) during light, dark adaptation and flicker light stimulation using the microsphere technique. Adult male Sprague-Dawley rats were anesthetized with isoflurane. Eyes were dark (Group I, n = 8), light (Group II, n = 8) adapted or stimulated with 10 Hz flicker light (Group ...
Enkel Thomas - - 2013
Subchronic treatment with the N-methyl-D-aspartate receptor antagonist phencyclidine (PCP) is a valuable approach to model the symptomatology of schizophrenia, a multi-facetted psychiatric disorder, in rodents. We addressed the question whether subchronic PCP (scPCP) treatment (5mg/kg bidaily for 7 days) would affect anxiety in rats, since contradictory findings have been reported ...
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