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Zhao Jianhua J British Columbia Cancer Research Center, Imaging Unit-Integrative Oncology Department, 675 West 10th Avenue, Vancouver, BC V5Z 1L3, CanadabUniversity of British Columbia and Vancouver Coastal Health Research Institute, Photomedicine Institute, - - 2014
ABSTRACT. One challenge in facing the application of biomedical Raman spectroscopy is that the Raman signal is acquired in a dark operation room. It is inconvenient for both the operator and the patient because it is difficult for the operator to accurately and precisely locate the target in the dark ...
Piepenbrock Cosima C a Department of Experimental Psychology, Institut für Experimentelle Psychologie , Heinrich-Heine-Universität , Düsseldorf , - - 2014
The 'positive polarity advantage' describes the fact that reading performance is better for dark text on light background (positive polarity) than for light text on dark background (negative polarity). We investigated the underlying mechanism by assessing pupil size and proofreading performance when reading positive and negative polarity texts. In particular, ...
Louis Elan D ED GH Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, - - 2014
The features of the tremor in essential tremor are often not fully appreciated, and essential tremor is frequently mis-diagnosed. Close inspection indicates that the tremor is characterized by a specific and definable pattern of features. Recognizing these features will aid in the diagnosis. The features are as follows: (1) kinetic ...
Marc Robert - - 2014
Three technologies have emerged as therapies to restore light sensing to profoundly blind patients suffering from late-stage retinal degenerations: (1) retinal prosthetics, (2) optogenetics and (3) chemical photoswitches. Prosthetics are the most mature and the only approach in clinical practice. Prosthetic implants require complex surgical intervention and provide only limited ...
Kim D H DH Department of Dermatology, Korea University College of Medicine, Seoul, - - 2014
The quantitative difference of the light reflected from a skin surface can be analyzed using parallel-polarized light (PPL) photography when combined with an analytic technique similar to colorimetric photography. To improve the PPL photography technique as an assessment tool for the evaluation of skin condition using light-emitting diodes (LED) of ...
Dragas Rachel R Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, - - 2014
Vigabatrin (VGB), a treatment for the childhood epilepsy, infantile spasms (IS), is implicated in visual field constriction. Electroretinograms (ERGs) are used as a substitute for visual field testing in infants. We use the VGB-associated ERG reduction (VAER), defined as reduction in age-corrected light adapted 30 Hz flicker amplitude from a pre-treatment ...
Bisschop Arno A Department of Orthopaedic Surgery, Research Institute MOVE, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. Electronic address: - - 2014
Degenerative lumbar spinal stenosis causes neurological symptoms due to neural compression. Lumbar laminectomy is a commonly used treatment for symptomatic degenerative spinal stenosis. However, it is unknown if and to what extent single level laminectomy affects the range of motion and stiffness of treated and adjacent segments. An increase in ...
Sánchez-Andrade Isabel Vaamonde IV Division of Neurotology, Servicio de Otorrinolaringología, Complejo Hospitario Universitario de Santiago, Travesía da Choupana, s/n, 15706, Santiago de Compostela, Spain, - - 2014
Vestibular evoked myogenic potentials (VEMPs) are currently considered a diagnostic tool for studying the vestibular system, specifically the saccule and inferior vestibular nerve. This prospective study aimed at evaluating the impact of patient position and type of acoustic stimulus on VEMPs results using 60 healthy subjects who underwent otoscopy, pure ...
Pérez-Villa Yolanda E YE Servicio de Audiología, Instituto Nacional de Rehabilitación, Distrito Federal, - - 2014
The sensitivity of prediction of acoustic reflex, in determining the level of hearing loss, is especially useful in paediatric populations. It is based on the difference between the pure tone stapedius reflex threshold and contralateral white noise. The white noise threshold was 60dB and that of pure tone was 80dB. ...
Hidalgo Manuel - - 2014
Mounting evidence now shows that fishing activity modifies both heritable life-history traits and ecological processes in harvested populations. However, ecological and evolutionary changes are intimately linked and can occur on the same time scale, and few studies have investigated their combined effect on fish population dynamics. Here, we contrast two ...
Song Hongxin H Center for Visual Science, University of Rochester, Rochester, New - - 2014
IMPORTANCE Fundus albipunctatus (FA) is a form of congenital stationary night blindness characterized by yellow-white spots, which were classically described as subretinal. Although night blindness and delayed dark adaptation are hallmarks of this condition, recent studies have described a macular phenotype, particularly among older patients. Using a fluorescence adaptive optics ...
Dickinson Abigail A Department of Psychology, University of Sheffield, Western Bank, Sheffield, S10 2TP, - - 2014
Enhanced low-level perception, although present in individuals with autism, is not seen in individuals with high, but non-clinical, levels of autistic traits (Brock et al.in Percept Lond 40(6):739. doi: 10.1068/p6953 , 2011). This is surprising, as many of the higher-level visual differences found in autism have been shown to correlate ...
Fogang Y Y Headache Research Unit, University of Liège, CHR Citadelle, Liège, Belgium, - - 2014
Enhanced photic driving (PD) during high-frequency flicker stimulation, the so-called H response, is a classical feature of migraine patients between attacks, but is thought to be of poor clinical utility. Visual inspection of the EEG for its detection may not be reliable, however, data on its possible correlations with clinical ...
Nesher Nir N Department of Neurobiology, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 91904, Israel; School of Marine Sciences, Ruppin Academic Center, Michmoret 40250, - - 2014
Controlling movements of flexible arms is a challenging task for the octopus because of the virtually infinite number of degrees of freedom (DOFs) [1, 2]. Octopuses simplify this control by using stereotypical motion patterns that reduce the DOFs, in the control space, to a workable few [2]. These movements are ...
Theunissen Eleonoor A R EA Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, The - - 2014
This study aimed to propose an ototoxicity grading system sensitive to the effect of ototoxicity on specific daily life situations like speech intelligibility and the perception of ultra-high sounds and to test its feasibility compared to current criteria. Pure tone averages (PTAs) for speech perception (1-2-4 kHz) and ultra-high frequencies ...
Venkatesan Lalit L Communication Neuroscience Laboratories, University of Nebraska, 141 Barkley Memorial Center, Lincoln, NE 68583, USA. Electronic address: - - 2014
TAC-Cell is a custom-built somatosensory stimulator that delivers pneumatic cutaneous tactile inputs to virtually any skin target on the body and by virtue of its non-ferrous materials is compatible with functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) brain scanners. In this study, we describe the method to measure apparent ...
Mumgaard Robert T RT MIT Plasma Science and Fusion Center, Cambridge, Massachusetts 02139, - - 2014
The capability to calibrate diagnostics, such as the Motional Stark Effect (MSE) diagnostic, without using plasma or beam-into-gas discharges will become increasingly important on next step fusion facilities due to machine availability and operational constraints. A robotic calibration system consisting of a motorized three-axis positioning system and a polarization light ...
Wu Shasha S Department of Neurology, Adult Epilepsy Center, University of Chicago Medical Center, Chicago, Illinois, - - 2014
To assess the role of ictal baseline shifts (IBS) and ictal high-frequency oscillations (iHFOs) in intracranial electroencephalography (EEG) presurgical evaluation by analysis of the spatial and temporal relationship of IBS, iHFOs with ictal conventional stereo-electroencephalography (icEEG) in mesial temporal lobe seizures (MTLS). We studied 15 adult patients with medically refractory ...
Nucci Paolo P University Eye Clinic, San Giuseppe Hospital, University of Milan, Via San Vittore 12, 20123, Milan, Italy, - - 2014
The cause of the anomalous head posture (AHP) has been mainly assigned to ocular, orthopedic, and neurologic causes. The AHP can take the form of head tilt, face turn, chin up, chin down, or combined, depending on the specific etiology. However, there are many variations, and the type of the ...
Lechner Corinna C Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Central Clinical School, University of Sydney, Sydney, NSW, - - 2014
Direction changing horizontal positional nystagmus can be observed in a variety of central and peripheral vestibular disorders. We tested sixty subjects with horizontal positional nystagmus and vertigo on the Epley Omniax(®) rotator. Monocular video recordings were performed with the right or left ear down, in the supine and prone positions. ...
Gardiner Stuart K SK Devers Eye Institute, Legacy Research Institute, Portland, Oregon. Electronic address: - - 2014
Visual field testing uses high-contrast stimuli in areas of severe visual field loss. However, retinal ganglion cells saturate with high-contrast stimuli, suggesting that the probability of detecting perimetric stimuli may not increase indefinitely as contrast increases. Driven by this concept, this study examines the lower limit of perimetric sensitivity for ...
Tibbetts Michael D MD Department of Ophthalmology, Tufts Medical Center, Boston, - - 2014
IMPORTANCE Clinical trials indicate that visual impairment is significantly greater in patients receiving ocriplasmin than placebo. The mechanism of this symptom has not been explained. We report a patient with persistent darkening of her vision after intravitreal ocriplasmin and describe ancillary testing findings that may yield insights into the effects ...
Forbes Dorothy D Faculty of Nursing, University of Alberta, level 3, Edmonton Clinic Health Academy, Edmonton, Alberta, Canada, - - 2014
Rest-activity and sleep-wake cycles are controlled by the endogenous circadian rhythm generated by the suprachiasmatic nuclei (SCN) of the hypothalamus. Degenerative changes in the SCN appear to be a biological basis for circadian disturbances in people with dementia, and might be reversed by stimulation of the SCN by light. The ...
Bhole Malini V MV Department of Immunology, Russells Hall Hospital, The Dudley Group NHS Foundation Trust, Dudley, - - 2014
In the last decade, the introduction of the serum-free light-chain (sFLC) assay has been an important advance in the diagnosis and management of plasma cell dyscrasias, particularly monoclonal light-chain diseases. The immunoassay was developed to detect free light chains in serum by using anti-FLC antibodies which specifically recognised epitopes on ...
Hefferman Gerald M GM 1Neuromuscular Rehabilitation Engineering Laboratory, Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island, Kingston, - - 2014
Background and aim:In recent years, there has been an increased interest in recording high-quality electromyographic signals from within the sockets of lower-limb amputees. However, successful recording presents major challenges to both researchers and clinicians. This article details and compares four prototypical integrated socket-sensor designs used to record electromyographic signals from ...
Lowrey Catherine R CR 1Queen's - - 2014
Skin sensory input from the foot soles is coupled with vestibular input to facilitate body orientation in a gravitational environment. Anecdotal observations suggest that foot sole skin becomes hypersensitive following space flight. The veritable level of skin sensitivity and its impact on postural disequilibrium observed post space flight have not ...
Marta S N SN Dentistry School, Graduate Studies, Sacred Hearth University, Bauru, - - 2014
The aim of this study is to evaluate the light-touch sensation of the oral mucosa in leprosy patients. A cross-sectional study included 228 adults, 133 being leprosy patients and 95 normal controls. To assess light-touch sensation, the five-filament standard Semmes-Weinstein kit in eight regions of the oral mucosa was used. ...
Kim Hyo-Jung HJ Biomedical Research Institute, Seoul National University Bundang Hospital, Seongnam, - - 2014
Rebound nystagmus is a transient nystagmus that occurs on resuming the straight-ahead position after prolonged eccentric gaze. Even though rebound nystagmus is commonly associated with gaze-evoked nystagmus (GEN), development of rebound nystagmus in a different plane of gaze has not been described. We report a patient with episodic ataxia type ...
Jin Guorui G Department of Mechanical Engineering, National University of Singapore, 2 Engineering Drive 3, Singapore, 117576; Center for Nanofibers and Nanotechnology, E3-05-14, Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, 2 Engineering Drive 3, Singapore, - - 2014
Tissue engineered skin grafts that mimic the native extracellular matrix (ECM) of skin has gained huge popularity among clinicians since they increase the survival rate of the patients. Phototherapy shows promising results with respect to acute and chronic pain relief, treatment of inflammatory conditions, and promotion of wound healing. Here, ...
Lyyra Pessi P Department of Psychology, University of Jyväskylä, Jyväskylä, Finland ; Human Information Processing Laboratory, School of Social Sciences and Humanities, University of Tampere, Tampere, - - 2014
Change blindness refers to the inability to detect visual changes if introduced together with an eye-movement, blink, flash of light, or with distracting stimuli. Evidence of implicit detection of changed visual features during change blindness has been reported in a number of studies using both behavioral and neurophysiological measurements. However, ...
Giannoni Alberto A International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College, London, United Kingdom ; Department of Cardiovascular Medicine, Fondazione Toscana G. Monasterio, Pisa, - - 2014
Clinicians are sometimes advised to make decisions using thresholds in measured variables, derived from prognostic studies. We studied why there are conflicting apparently-optimal prognostic thresholds, for example in exercise peak oxygen uptake (pVO2), ejection fraction (EF), and Brain Natriuretic Peptide (BNP) in heart failure (HF). Studies testing pVO2, EF or ...
Yang Shifeng S Shandong Medical Imaging Research Institute, Shandong University, Jinan, Shandong, P.R. - - 2014
To evaluate the feasibility of dose-modulated retrospective ECG-gated thoracoabdominal aorta CT angiography (CTA) assessing abdominal aortic intimal flap motion and investigate the motion characteristics of intimal flap in acute aortic dissection (AAD). 49 patients who had thoracoabdominal aorta retrospective ECG-gated CTA scan were enrolled. 20 datasets were reconstructed in 5% ...
Kraj Maria M Institute of Hematology and Transfusion Medicine, Warsaw, - - 2014
Immunofixation (IFE) is a standard method for detecting monoclonal immunoglobulins and characterizing its isotype. Recently clonality can also be determined by using immunoglobulin (Ig) heavy chain/light chain immunoassays - HLC, HevyliteTM. HLC separately measures in pairs light chain types of each intact Ig class generating ratios of monoclonal Ig/uninvolved polyclonal ...
Coste Christine Azevedo CA INRIA-LIRMM, Montpellier 34095, France. - - 2014
Freezing of gait (FOG) is a common symptom in Parkinsonism, which affects the gait pattern and is associated to a fall risk. Automatized FOG episode detection would allow systematic assessment of patient state and objective evaluation of the clinical effects of treatments. Techniques have been proposed in the literature to ...
Wan Marilyn T MT Melanoma Program, Dana-Farber Cancer Institute, Boston, MA, - - 2014
In photodynamic therapy (PDT) a photosensitizer - a molecule that is activated by light - is administered and exposed to a light source. This leads both to destruction of cells targeted by the particular type of photosensitizer, and immunomodulation. Given the ease with which photosensitizers and light can be delivered ...
Tousseyn Simon S Laboratory for Epilepsy Research, UZ Leuven and KU Leuven , Leuven , Belgium ; Medical Imaging Research Center, UZ Leuven and KU Leuven , Leuven , - - 2014
There is currently a lack of knowledge about electroencephalography (EEG)-functional magnetic resonance imaging (fMRI) specificity. Our aim was to define sensitivity and specificity of blood oxygen level dependent (BOLD) responses to interictal epileptic spikes during EEG-fMRI for detecting the ictal onset zone (IOZ). We studied 21 refractory focal epilepsy patients ...
Furuhata Masanori M Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, - - 2014
We herein describe the case of a 77-year-old woman with acquired factor X deficiency that was likely caused by atypical amyloidosis. The patient developed severe gastrointestinal bleeding as a result of a significant decrease of factor X activity. Neither proteinuria nor diarrhea was observed as an initial manifestation. Although a ...
Cho Sun Young - - 2014
Because free light chain assays measure polyclonal as well as monoclonal free light chain components, some previous studies focused on the potential utility of the free light chain assay for detecting chronic immune stimulation, which occurs in autoimmune diseases and allergies. However, most of these trials have been limited to ...
Porges Stephen W SW Department of Psychiatry, University of North Carolina at Chapel Hill , Chapel Hill, NC , - - 2014
Auditory hypersensitivities are a common feature of autism spectrum disorder (ASD). In the present study, the effectiveness of a novel intervention, the listening project protocol (LPP), was evaluated in two trials conducted with children diagnosed with ASD. LPP was developed to reduce auditory hypersensitivities. LPP is based on a theoretical ...
Bhorade Anjali M AM Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, - - 2013
Patients often report greater visual difficulties at home than expected from vision testing in the clinic. Such discordance may be owing to worse vision in the home than measured in clinic. To compare vision measured between the clinic and home and evaluate factors, including lighting, associated with these differences. This ...
Wunsch Alexander - - 2013
Abstract Objective: The purpose of this study was to investigate the safety and efficacy of two novel light sources for large area and full body application, providing polychromatic, non-thermal photobiomodulation (PBM) for improving skin feeling and appearance. Background data: For non-thermal photorejuvenation, laser and LED light sources have been demonstrated ...
Graziani Maria Stella - - 2013
The serum free light chain (FLC) assay is an important tool in the management of patients with monoclonal gammopathies. MEDLINE®, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews from January 2000 through July 2013, were used as data sources. The available evidence is rather ...
Jafari Zahra - - 2013
Human modalities play a vital role in the way the brain produces mental representations of the world around us. Although congenital blindness limits the understanding of the environment in some aspects, blind individuals may have other superior capabilities from long-term experience and neural plasticity. This study investigated the effects of ...
Jee T T Department of Mechanical Engineering, University of California, Berkeley, CA 94720, - - 2013
Time-dependent deformation of porcine skin was studied in vitro using specialized microprobe instruments. The deformation behavior of stratum corneum, dermis, and whole skin is examined in the context of results of creep strain, elastic stiffness, and viscoelastic constants obtained in terms of the hold time, loading/unloading rate, and maximum indentation ...
Korenbrot Juan I JI Departments of Ophthalmology and Physiology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, Albert Eye Research Institute, Duke University Medical Center, Durham, North Carolina 27710, and Department of Biology, University of Oregon, Eugene, Oregon - - 2013
The ligand sensitivity of cGMP-gated (CNG) ion channels in cone photoreceptors is modulated by CNG-modulin, a Ca(2+)-binding protein. We investigated the functional role of CNG-modulin in phototransduction in vivo in morpholino-mediated gene knockdown zebrafish. Through comparative genomic analysis, we identified the orthologue gene of CNG-modulin in zebrafish, eml1, an ancient ...
Bittner Ava K AK Johns Hopkins University, Wilmer Eye Institute, Baltimore, Maryland, USA. - - 2014
Patients with retinitis pigmentosa are motivated to try complementary or integrative therapies to slow disease progression. Basic science, clinical research and retinitis pigmentosa patients' self-reports support the hypothesis that acupuncture may improve visual function. A prospective, case series, pilot study enrolled 12 adult patients with RP treated at an academic ...
Zhang Pengpeng - - 2013
To develop an optimization algorithm for volumetric modulated arc therapy which incorporates an electromagnetic tracking (EMT) guided gating strategy and is robust to residual intra-fractional motion uncertainties. In a computer simulation, intra-fractional motion traces from prior treatments with EMT were converted to a probability distribution function (PDF), truncated using a ...
de Boer-Schellekens Liselotte - - 2013
Here, we examined sensitivity of visual, auditory, and audiovisual temporal order in five age-groups (20 to 70 years old). We also measured multisensory integration (MSI) using a phenomenon known as "temporal ventriloquism," in which click sounds improve sensitivity of visual temporal order. Results showed that sensitivity of visual, auditory, and audiovisual ...
Baldwin Margaret - - 2013
This study examined the ability of click auditory brainstem response (ABR) undertaken below the age of 6 months (from expected date of delivery) to differentiate between conductive and sensorineural hearing loss (SNHL), using the latency of wave V measured 20 dB above threshold. Subjects were recruited if they had an ...
Ye Yun - - 2013
The study aimed to evaluate the levels of serum free kappa (κ) and lambda (λ) light chains in patients with rheumatoid arthritis (RA) as well as exploring the association between serum free κ and λ light chains and activity of RA. For this purpose, healthy individuals and patients with active RA ...
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