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Montgomery Nathan D ND Dept of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, CB #7525, Brinkhous-Bullitt Bldg, Chapel Hill, NC 27599-7525; - - 2014
Objectives Syringomatous adenoma of the nipple (SAN) is a rare benign infiltrative neoplasm that may be confused with low-grade breast carcinomas. We report the case of 71-year-old woman with a fungating left breast mass and subareolar calcifications in the contralateral breast. Methods Histomorphologic features were evaluated with standard H&E-stained sections. ...
Lu Lucy X LX Vanderbilt University School of Medicine, Nashville, - - 2014
IMPORTANCE IgG4-related hypertrophic pachymeningitis (IgG4-RHP) is an increasingly recognized manifestation of IgG4-related disease, a fibroinflammatory condition that can affect virtually any organ. It is estimated that IgG4-RHP may account for a high proportion of cases of hypertrophic pachymeningitis once considered idiopathic. OBJECTIVE To summarize the current knowledge on IgG4-RHP including ...
Alexander John J Department of Pathology, College of Medicine, Wexner Medical Center, The Ohio State University, 405 Doan Hall, 410 West 10th Avenue, Columbus, OH, 43210, - - 2014
We present an example of clear cell chondrosarcoma (CCC) arising in the thyroid cartilage, and review the literature regarding this neoplasm in the larynx. This patient has no evidence of disease 3 years post hemilaryngectomy. Although rare and morphologically distinct, CCC follows the same benign clinical course as conventional laryngeal chondrosarcoma.
Bowen Joslin M JM Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, - - 2014
Few studies have examined the value of a mandatory second review of outside pathology material for haematological malignancies. Therefore, we compared diagnoses on biopsies referred to an academic medical centre to determine the rate and therapeutic impact of revised diagnoses resulting from a second review. We reviewed 1010 cases referred ...
Harvey Nathan T NT *Department of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, Australia; †School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia; ‡CliniPath Pathology, West Perth, Australia; §Healthscope Pathology, Queensland, Australia; and ¶Dermatopathology WA, Cottesloe, - - 2014
To describe the features of 4 cases of basal cell carcinosarcoma and systematically review previously reported cases. Four cases of basal cell carcinosarcoma were identified from the practice of the authors. A search of the literature revealed an additional 40 cases, variously described in small series and single case reports. ...
Lv Meiling M Department of Clinical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710061, P.R. - - 2014
Splenic metastasis of ovarian cancer appears to be more common in serous cystadenocarcinomas. Splenic metastasis usually occurs postoperatively and simultaneously with dissemination to the greater omentum and pelvic cavity. Compared with other ovarian cancer subtypes, ovarian clear cell adenocarcinoma (OCCA) is rare, accounting for <5% of all ovarian malignancies. OCCA ...
Lapresto Lindsay - - 2014
Porphyria cutanea tarda (PCT) is a blistering skin disorder that occurs most commonly in middle-aged individuals. It is caused by decreased uroporphyrinogen decarboxylase (UROD) activity, which results in elevated levels of uroporphyrinogen. Occurrence remains very rare in children with some sources quoting as few as 50 reports of childhood cases.1 ...
Al-Hussain Turki T Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia, - - 2014
Follicular dendritic cell sarcoma (FDCS) of the parapharyngeal space is a rare malignant tumor. Only eleven cases of FDCS of the parapharyngeal space have been reported in English literature. Most of the reported cases developed tumor recurrence within 1 year or had metastasis. Because of the rarity of FDCS in the ...
Lee Pristine W PW Department of Dermatology, Kaiser Permanente, San - - 2014
Noninvoluting congenital hemangioma (NICH) is a distinct vascular tumor of infancy. We describe the clinical characteristics, histopathology, imaging, and natural history of NICH and compare our findings with previous reports. We conducted a retrospective review of charts and photographic databases from 2 vascular anomaly centers over a 15-year period. Thirty ...
Phillips Katherine K a University of Florida, Pathology, Immunology, and Laboratory - - 2014
Abstract We report the postmortem findings of two siblings with gross and microscopic features consistent with IMAGe association (Intrauterine growth retardation, Metaphyseal dysplasia, Adrenal hypoplasia congenita, and Genital anomalies) with an emphasis on the histopathology of the adrenal gland in this rare syndrome. The first sibling was an 8-week old ...
Hsi Eric D ED *Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH †Department of Pathology, University of California Los Angeles, Los Angeles, CA ‡Department of Anatomic Pathology ¶Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN §Department of Pathology, Brigham and Women's Hospital, Boston, MA ∥British Columbia Cancer Agency, Vancouver, BC, - - 2014
The diagnosis of peripheral T-cell and NK-cell lymphomas (PTNKCL) is difficult with few standards for required ancillary studies. We evaluated a series of PTNKCLs using a tiered approach to immunohistochemistry and molecular genetic characterization to document diagnostic accuracy and clinical relevance. Seven hematopathologists reviewed 374 cases that included PTNKCL and ...
Takahama Ademar A - - 2014
Oral squamous cell carcinoma (SCC) is considered a primarily localized disease, and distant metastasis is not common. An increasing number of case reports involving unusual sites for distant metastasis from oral carcinoma have been reported in the literature. This is likely due to the improved control of cancer at the ...
Shahid Mohammad M Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, - - 2014
Schwannomas are benign nerve sheath tumors composed of Schwann cells, which normally produce the insulating myelin sheath covering the peripheral nerves. Common locations include the head, neck, mediastinum, and retroperitoneum. These tumors are usually asymptomatic until they become large and compress the surrounding tissues. Most schwannomas occur during the third ...
Won Young-Woong YW Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South - - 2014
Hairy cell leukemia (HCL) is a very rare mature B-cell neoplasm and its simultaneous occurrence with chronic myeloid leukemia has been reported in only three cases. The pathogenesis and relationship of the two diseases are not clear. Here we report a case of HCL expressing a BCR/ABL1 clone, which showed ...
Góes Luccas Santos Patto de LS Hospital do Servidor Público Municipal de São Paulo, São Paulo, SP, - - 2014
A 23-year-old male with a history of bone marrow transplant for acute myeloid leukemia. He presented a large mass in the right inguinal region 5 years ago. Upon physical examination, right-sided cryptorchidism was observed. The tumor markers alpha-fetoprotein and beta-HCG were within normalcy range and lactate dehydrogenase was raised. Computed ...
Adams Chad C CC 2903 Ivydale St, Silver Spring, MD 20902, USA. - - 2014
Perineural invasion (PNI) is an uncommon manifestation of cutaneous squamous cell carcinoma (SCC). We report a case of recurrent cutaneous SCC with PNI diagnosed both clinically and histologically. We also provide a review the literature. Clinicians should be aware of this uncommon finding, as PNI has been associated with increased ...
Zheng Yan - - 2014
Intravascular fasciitis is an uncommon variant of nodular fasciitis, which is a reactive proliferative lesion of myofibroblasts. Since its identification in 1981, only 32 cases of intravascular fasciitis have been reported in the English literature. The lesion is commonly located in the head, neck, and extremities, with only three cases ...
Mete Mesut M 1Celal Bayar University, School of Medicine Neurosurgery Department, Manisa, - - 2014
Congenital dermal sinus tract is a rare entity which lined by epithelial cells and can end anywhere between subcutaneous planes to thecal sac. These tracts may be accompanied with other pathologies such as lipomyelomeningocele, myelomeningocele, split cord malformation, tethered cord, filum abnormality and inclusion tumors and treatment includes resection of ...
Mayson E E Haematology Department, Wollongong Hospital, Wollongong, New South Wales, - - 2014
Haemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal disease of children and adults. Cytokine dysfunction, uncontrolled accumulation of activated T-cells and histiocytes, and the inability to terminate the immune response lead to the clinical manifestations of extreme inflammation and end-organ damage. HLH is notoriously underreported because of its ability ...
Pina Annick A 1Obstetrics & Gynecology Department, Université de Montréal, CHUM, Hôpital Saint-Luc; 2Gynecologic Oncology Division, Obstetrics & Gynecology Department, Université de Montréal, CHUM, Hôpital Notre-Dame; 3Pathology Department, Université de Montréal, CHUM, Hôpital Notre-Dame, Montreal (Quebec), - - 2014
Trichoblastomas are rare and benign tumors that arise from rudimentary hair follicles. Presentation varies from superficial plaques to papular or nodular lesions. Trichoblastomas usually arise on the head or neck. A few cases of other vulvar trichoblastic tumors such as trichofibromas and trichoepitheliomas have been reported to this day, but ...
Coli Antonella A Department of Anatomic Pathology, Catholic University, Largo F. Vito 1, 00168, Rome, Italy, - - 2014
The presence of cartilage in gliomas is a very unusual finding and has been mainly reported in ependymomas and in astrocytomas. A derivation of cartilage from neuroepithelial cells through a neuroepithelial-mesenchymal transition or directly from blood vessel-associated multipotent stromal elements has been proposed. We herein describe a further case of ...
Xia Yan Y Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, PR China; Department of Pathology, Medical College, Qingdao University, Qingdao, PR - - 2014
Primary intravascular large B cell lymphoma (IVLBCL) of the endometrium is extremely rare. So far, only 5 cases have been reported in the English literature. We now report a new case of endometrial IVLBCL which exhibited distinct clinicopathological characteristics and meaningful laboratory tests, and also review the literature. A 66-year-old ...
Kyriakou A A 2nd Dermatology Department, Aristotle University School of Medicine, Thessaloniki, - - 2014
Plasma cell balanitis of Zoon (PCBZ) and plasma cell vulvitis (PCV) are characterized as idiopathic, benign, chronic irritant mucositis. The clinical symptoms and signs usually persist or reappear after treatment withdrawal. Therefore, many therapies have been tried and are available. Recently, several reports of PCBZ and PCV treated with calcineurin ...
Men Hai-Tao - - 2014
Our previous study showed that the features of epidermal growth factor receptor (EGFR)-RAS signaling in penile squamous cell carcinoma (SCC) suggested potential benefits of anti-EGFR monoclonal antibodies (mAbs) for penile SCC. Here, we report, for the first time, a combination of nimotuzumab (an EGFR mAb) with chemotherapy that resulted in ...
Tacke Zwanique C A ZC *Division of Pediatric Oncology/Hematology Departments of †Child Neurology §Pathology, VU University Medical Center, Amsterdam ‡Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The - - 2014
Lymphomatoid granulomatosis (LG) is a B-cell type lymphoproliferative disease. It mainly affects the lungs but may have extrapulmonary manifestations, especially in the central nervous system. The purpose of this study was to review the pediatric cases in the literature and add 2 new cases to the existing literature. A review ...
Mamoon Nadira N Department of Histopathology, Shifa International Hospital, - - 2014
The nested variant of urothelial carcinoma is a rare but very important histological entity due to its deceptively bland-looking appearance and aggressive behavior. We present a case of a 30-year-old man who was found to have a solitary polypoid growth in the bladder. It was resected and found to be ...
Ghostine B B Department of Orthopedic Surgery, Hotel Dieu de France Hospital, Alfred Naccache Street, Achrafieh, P.O. Box 166830, Beirut, - - 2014
Introduction. Giant cell tumors (GCTs) of bone are known for their local aggressiveness and high recurrence rate. There are rare cases of multicentric GCT and most are synchronous. We herein review metachronous multicentric GCT reported in the literature. Material and Methods. A MEDLINE, Cochrane, and Google Scholar search was done ...
Suzuki Tomotaka T Department of Hematology, Toyokawa City Hospital, - - 2014
We herein describe the case of a 77-year-old Japanese man who presented with progressive thrombocytopenia. No lymphadenopathies, bone lesions, hepatosplenomegaly or masses within any internal organs were detectable. Bone marrow smears revealed diffuse infiltration of large atypical cells morphologically resembling mature lymphoid neoplasms. A flow cytometric analysis showed that the ...
Zhang Ming M Department of Pathology, Yantai Yantaishan Hospital Yantai, Shandong, - - 2014
Small-cell extraskeletal osteosarcoma is extremely rare and consists of sheets of small round cells with variable amounts of osteoid. This tumor is often difficult to diagnose when tissue samples do not include recognizable osteoid. Only four cases have been reported in English and none in Chinese. We report a typical ...
Kumar Kuppusamy Santhosh S Department of Oral & Maxillofacial Pathology, Faculty of Dental Sciences, Sri Ramachandra University, Porur, Chennai, Tamil Nadu 600116, - - 2014
Neurinoma or schwannoma is an uncommon benign tumor that arises primarily from the nerve sheath of Schwann cells. About 25% has been reported in head and neck region extracranially, but only 1% in the intraoral origin. Intraorally, the tongue is the most common site followed by the palate, floor of ...
Tanaka Yusuke Y Department of Obstetrics and Gynecology, Osaka Rosai Hospital, 1179-3 Nagasone, Kita-ku, Sakai, Osaka 5918025, Japan. - - 2014
Mature cystic teratomas are benign neoplasms of germ cell tumors that occur most frequently in gonadal sites. The tumors usually contain 2 or 3 well-differentiated elements of endodermal, ectodermal, and mesodermal origin. Although relatively uncommon, teratomas can be composed of mature tissue originating from only 1 germ cell layer. This ...
He Hong-Lin HL Department of Pathology, E-DA Hospital and I-Shou University Kaohsiung, - - 2014
Hilus cell heterotopia is the presence of normal hilus cells in an abnormal site. It is rare and there are only a few case reports or case series. It has been reported in the fimbrial stroma of the fallopian tube, paratubal cyst wall and beneath ovarian capsule. Most cases are ...
Arul A Sri Kennath J AS Department of Oral and Maxillofacial Pathology, Best Dental Science College, Madurai, Tamil Nadu, - - 2014
Rhabdomyosarcoma is a malignant tumor composed of neoplastic mesenchymal cells, with varying degrees of striated muscle cell differentiation. With most cases occurring in children younger than 10 years, it is remarkably rare in adults. Further in adults, the typical pediatric rhabdomyosarcoma variants (embryonal and alveolar sub-types) occur less frequently and ...
Naik Raghavendra Mahadev RM Department of Oral Medicine and Radiology, Vishnu Dental College and Hospital, Bhimavaram, Andhra Pradesh, - - 2014
Cemento-ossifying fibroma (COF) is classified as a fibro-osseous neoplasm and included among the non-odontogenic tumors derived from the mesenchymal blast cells of the periodontal ligament, with a potential for forming fibrous tissue, cementum and bone, or a combination of such elements. These are slow-growing lesions, and are more frequent in ...
Khera Rachna - - 2014
Clear cell papillary cholangiocarcinoma is a rare variant of intrahepatic cholangiocarcinoma with only nine reported cases in the literature. This tumor needs to be differentiated from clear cell variant of hepatocellular carcinoma and other metastatic clear cell carcinomas. This tumor is known to have better prognosis compared to conventional intrahepatic ...
Sable Mukund N - - 2014
Extra-gonadal malignant transformation of teratoma is rare and there are only a few reports available citing malignancy arising in the non-germ cell components. We hereby report a case of a 35-year-old female, who presented with lower backache with a radiologically identifiable mass lesion in the pre-sacral region. Clinical and radiological ...
Kumar R - - 2013
Metastatic renal cell carcinoma (RCC) in the nose and paranasal sinuses is very rare. We report an unusual case of metastatic RCC that presented as recurrent epistaxis ten years after curative nephrectomy. The purpose of this report is to draw the attention of clinicians to the possibility of metastatic RCC ...
Xu Sheng-Sheng SS Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address: - - 2013
Intravascular papillary endothelial hyperplasia was a rare benign vascular proliferative process as a result of papillary proliferation of the endothelial cells within the vessels. To our knowledge, we reported the second case occurring in the madibule, and the first reported in 1984 in the literature. We discussed manifestations of multislice ...
Chen Li-Li - - 2013
Trichogerminoma is a rare cutaneous adnexal neoplasm of the hair germ cell and usually associated with benign clinical course and favorable outcome. Since its first description by Sau et al. in 1992, only a few cases have been reported up to date. Herein, we report two additional cases occurring in ...
Ka┼║mierczak Maciej M Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Szamarzewskiego 84, 60-569, Poznan, Poland, - - 2014
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most common form of leukemia affecting adults in Europe and North America. Large B-cell lymphoma known as Richter's syndrome (RS) may develop approximately in 3-15 % patients. Furthermore, other hematological malignancies may also occur as RS variants, among them-Hodgkin lymphoma (HL). CLL/SLL ...
Baumbach Sebastian F - - 2013
Olecranon bursitis and prepatellar bursitis are common entities, with a minimum annual incidence of 10/100,000, predominantly affecting male patients (80 %) aged 40-60 years. Approximately 1/3 of cases are septic (SB) and 2/3 of cases are non-septic (NSB), with substantial variations in treatment regimens internationally. The aim of the study was the development ...
Kothari Shalin - - 2013
Isolated extramedullary disease (EMD) is uncommon, especially in acute promyelocytic leukemia (APL) after allogeneic hematopoietic stem cell transplantation (HSCT). We review the literature and present a 32 year old woman with APL who developed multiple EMDs after allogeneic HSCT within the calvarium, and later found to have various isolated lesions ...
Xun Qiufen Q Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, - - 2013
We report a case of a 52-year-old Chinese woman with a history of primary hepatic cell carcinoma who presented with chest pain, cough, expectoration and bloody phlegm. Chest computer tomography (CT) revealed a 6.2 cm × 6.8 cm shallow lobulated irregular shaped mass in the hilum of the right lung. ...
Street Ryan - - 2013
Today the classic triad of flank pain, hematuria and a palpable abdominal mass is rarely present at initial diagnosis of renal cell carcinoma due to the growing number of cases diagnosed incidentally on imaging studies. We report a case of a 58-year-old female who presented with melena where a subsequent ...
Broehm Cory J CJ Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA. Electronic address: - - 2013
Bizarre parosteal osteochondromatous proliferation (BPOP) is a rare, benign osteocartilaginous lesion characterized by a mixture of immature bone, bland spindle cells, and irregular, hypercellular cartilage undergoing calcification. A t(1;17)(q32;q21) has been reported as a unique recurring translocation identified in seven cases. Inversion of chromosome 7, inv(7)(q22q32), has also recently been ...
Rozen Laurence - - 2013
Transient neonatal leukemia occurs almost exclusively in Down syndrome babies. We report here the unusual case of a newborn without Down syndrome who presented neonatal transient leukemia and who achieved spontaneously complete remission. Trisomy 21 and GATA1 mutation were both present in leukemic cells. While close follow-up is advised since ...
Kaplowitz Kevin - - 2013
Abstract A case report of a traumatic hyphema in a patient with sickle cell trait is presented. A review of the published literature in PubMed was performed and medical management strategies and surgical treatment indications for traumatic hyphema are discussed. We support the case for temporary trabeculectomy in patients with ...
Kalsi Amardip S AS DF2 in Restorative Dentistry, The Royal London Dental Hospital, London, United Kingdom. Electronic address: - - 2013
Clear cell odontogenic carcinoma (CCOC) is an extremely rare neoplasm, with only 74 cases in the English-language literature. It displays a propensity for the mandible, most commonly presenting in the fifth to seventh decades. Histopathologically, CCOC is characterized by sheets and islands of vacuolated and clear cells. The aggressive nature ...
Claassen Stephanie L - - 2013
: Granular cell basal cell carcinoma (BCC), characterized by large cells with abundant eosinophilic cytoplasm and conspicuous granularity, is an extremely rare variant of BCC with only 14 cases reported in the literature to date. A case of an 82-year-old man with clinically suspected BCC of the face is presented. ...
Kane Joshua Robert JR Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, - - 2014
Sarcomatoid (spindle cell) carcinoma of the pancreas is a rare, high-grade epithelial malignancy composed predominantly or exclusively of spindle cells demonstrating evidence of epithelial derivation, but no features indicative of a specific line of mesenchymal differentiation. The current study presents the case of an 85-year-old Caucasian male with a tumor ...
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