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Won Young-Woong YW Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South - - 2014
Hairy cell leukemia (HCL) is a very rare mature B-cell neoplasm and its simultaneous occurrence with chronic myeloid leukemia has been reported in only three cases. The pathogenesis and relationship of the two diseases are not clear. Here we report a case of HCL expressing a BCR/ABL1 clone, which showed ...
Góes Luccas Santos Patto de LS Hospital do Servidor Público Municipal de São Paulo, São Paulo, SP, - - 2014
A 23-year-old male with a history of bone marrow transplant for acute myeloid leukemia. He presented a large mass in the right inguinal region 5 years ago. Upon physical examination, right-sided cryptorchidism was observed. The tumor markers alpha-fetoprotein and beta-HCG were within normalcy range and lactate dehydrogenase was raised. Computed ...
Adams Chad C CC 2903 Ivydale St, Silver Spring, MD 20902, USA. - - 2014
Perineural invasion (PNI) is an uncommon manifestation of cutaneous squamous cell carcinoma (SCC). We report a case of recurrent cutaneous SCC with PNI diagnosed both clinically and histologically. We also provide a review the literature. Clinicians should be aware of this uncommon finding, as PNI has been associated with increased ...
Hui Wu Jian J Jian Hui Wu, Department of Urology, Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin First Center Hospital, Tianjin 300211, - - 2014
Pyeloduodenal fistula is a rare condition and its association with malignancy is even rarer. Herein we report the case of a 66-year-old man who was admitted to the hospital with a three-month history of intermittent melena and a more than 20-year history of right-side renal stones. Computed tomography showed a ...
Stojsic Zorica - - 2014
Composite hemangioendothelioma (CHE) is a rare, locally aggressive, vascular tumor of intermediate-/ low-grade malignancy, and is characterized by varying combinations of benign, low-grade malignant, and malignant vascular components. In cutaneous localization, only 22 cases have been reported so far. A new case of CHE of the gluteal region in a ...
Caffery Terrell T Assistant Professor of Louisiana State University Health Sciences Center's School of Medicine and the Program Director of the Louisiana State University Health Science Center's Emergency Medicine Residency Program in Baton - - 2014
A 33-year-old man presented to the emergency department (ED) with chief complaint of chest pain, persisting for approximately one year. Chest X-ray revealed he was missing the right posterior fifth rib. Physical examination showed no surgical scars, and he reported no history of chest trauma. A CT of his chest ...
Zheng Yan - - 2014
Intravascular fasciitis is an uncommon variant of nodular fasciitis, which is a reactive proliferative lesion of myofibroblasts. Since its identification in 1981, only 32 cases of intravascular fasciitis have been reported in the English literature. The lesion is commonly located in the head, neck, and extremities, with only three cases ...
Mete Mesut M 1Celal Bayar University, School of Medicine Neurosurgery Department, Manisa, - - 2014
Congenital dermal sinus tract is a rare entity which lined by epithelial cells and can end anywhere between subcutaneous planes to thecal sac. These tracts may be accompanied with other pathologies such as lipomyelomeningocele, myelomeningocele, split cord malformation, tethered cord, filum abnormality and inclusion tumors and treatment includes resection of ...
Mayson E E Haematology Department, Wollongong Hospital, Wollongong, New South Wales, - - 2014
Haemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal disease of children and adults. Cytokine dysfunction, uncontrolled accumulation of activated T-cells and histiocytes, and the inability to terminate the immune response lead to the clinical manifestations of extreme inflammation and end-organ damage. HLH is notoriously underreported because of its ability ...
Pina Annick A 1Obstetrics & Gynecology Department, Université de Montréal, CHUM, Hôpital Saint-Luc; 2Gynecologic Oncology Division, Obstetrics & Gynecology Department, Université de Montréal, CHUM, Hôpital Notre-Dame; 3Pathology Department, Université de Montréal, CHUM, Hôpital Notre-Dame, Montreal (Quebec), - - 2014
Trichoblastomas are rare and benign tumors that arise from rudimentary hair follicles. Presentation varies from superficial plaques to papular or nodular lesions. Trichoblastomas usually arise on the head or neck. A few cases of other vulvar trichoblastic tumors such as trichofibromas and trichoepitheliomas have been reported to this day, but ...
Daming Cui C Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University, Shanghai, - - 2014
Langerhans cell histiocytosis (LCH) is a rare disease of neoplastic proliferation of monocyte-macrophage system. Although LCH can affect almost any organ, solitary involvement of jugular foramen is extremely rare and can present a diagnostic dilemma because of its rarity at this location. Here, we present the case of an adult ...
Coli Antonella A Department of Anatomic Pathology, Catholic University, Largo F. Vito 1, 00168, Rome, Italy, - - 2014
The presence of cartilage in gliomas is a very unusual finding and has been mainly reported in ependymomas and in astrocytomas. A derivation of cartilage from neuroepithelial cells through a neuroepithelial-mesenchymal transition or directly from blood vessel-associated multipotent stromal elements has been proposed. We herein describe a further case of ...
Xia Yan Y Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, PR China; Department of Pathology, Medical College, Qingdao University, Qingdao, PR - - 2014
Primary intravascular large B cell lymphoma (IVLBCL) of the endometrium is extremely rare. So far, only 5 cases have been reported in the English literature. We now report a new case of endometrial IVLBCL which exhibited distinct clinicopathological characteristics and meaningful laboratory tests, and also review the literature. A 66-year-old ...
Kyriakou A A 2nd Dermatology Department, Aristotle University School of Medicine, Thessaloniki, - - 2014
Plasma cell balanitis of Zoon (PCBZ) and plasma cell vulvitis (PCV) are characterized as idiopathic, benign, chronic irritant mucositis. The clinical symptoms and signs usually persist or reappear after treatment withdrawal. Therefore, many therapies have been tried and are available. Recently, several reports of PCBZ and PCV treated with calcineurin ...
Men Hai-Tao - - 2014
Our previous study showed that the features of epidermal growth factor receptor (EGFR)-RAS signaling in penile squamous cell carcinoma (SCC) suggested potential benefits of anti-EGFR monoclonal antibodies (mAbs) for penile SCC. Here, we report, for the first time, a combination of nimotuzumab (an EGFR mAb) with chemotherapy that resulted in ...
Tacke Zwanique C A ZC *Division of Pediatric Oncology/Hematology Departments of †Child Neurology §Pathology, VU University Medical Center, Amsterdam ‡Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The - - 2014
Lymphomatoid granulomatosis (LG) is a B-cell type lymphoproliferative disease. It mainly affects the lungs but may have extrapulmonary manifestations, especially in the central nervous system. The purpose of this study was to review the pediatric cases in the literature and add 2 new cases to the existing literature. A review ...
Mamoon Nadira N Department of Histopathology, Shifa International Hospital, - - 2014
The nested variant of urothelial carcinoma is a rare but very important histological entity due to its deceptively bland-looking appearance and aggressive behavior. We present a case of a 30-year-old man who was found to have a solitary polypoid growth in the bladder. It was resected and found to be ...
Ghostine B B Department of Orthopedic Surgery, Hotel Dieu de France Hospital, Alfred Naccache Street, Achrafieh, P.O. Box 166830, Beirut, - - 2014
Introduction. Giant cell tumors (GCTs) of bone are known for their local aggressiveness and high recurrence rate. There are rare cases of multicentric GCT and most are synchronous. We herein review metachronous multicentric GCT reported in the literature. Material and Methods. A MEDLINE, Cochrane, and Google Scholar search was done ...
Suzuki Tomotaka T Department of Hematology, Toyokawa City Hospital, - - 2014
We herein describe the case of a 77-year-old Japanese man who presented with progressive thrombocytopenia. No lymphadenopathies, bone lesions, hepatosplenomegaly or masses within any internal organs were detectable. Bone marrow smears revealed diffuse infiltration of large atypical cells morphologically resembling mature lymphoid neoplasms. A flow cytometric analysis showed that the ...
Zhang Ming M Department of Pathology, Yantai Yantaishan Hospital Yantai, Shandong, - - 2014
Small-cell extraskeletal osteosarcoma is extremely rare and consists of sheets of small round cells with variable amounts of osteoid. This tumor is often difficult to diagnose when tissue samples do not include recognizable osteoid. Only four cases have been reported in English and none in Chinese. We report a typical ...
Kumar Kuppusamy Santhosh S Department of Oral & Maxillofacial Pathology, Faculty of Dental Sciences, Sri Ramachandra University, Porur, Chennai, Tamil Nadu 600116, - - 2014
Neurinoma or schwannoma is an uncommon benign tumor that arises primarily from the nerve sheath of Schwann cells. About 25% has been reported in head and neck region extracranially, but only 1% in the intraoral origin. Intraorally, the tongue is the most common site followed by the palate, floor of ...
Tanaka Yusuke Y Department of Obstetrics and Gynecology, Osaka Rosai Hospital, 1179-3 Nagasone, Kita-ku, Sakai, Osaka 5918025, Japan. - - 2014
Mature cystic teratomas are benign neoplasms of germ cell tumors that occur most frequently in gonadal sites. The tumors usually contain 2 or 3 well-differentiated elements of endodermal, ectodermal, and mesodermal origin. Although relatively uncommon, teratomas can be composed of mature tissue originating from only 1 germ cell layer. This ...
He Hong-Lin HL Department of Pathology, E-DA Hospital and I-Shou University Kaohsiung, - - 2014
Hilus cell heterotopia is the presence of normal hilus cells in an abnormal site. It is rare and there are only a few case reports or case series. It has been reported in the fimbrial stroma of the fallopian tube, paratubal cyst wall and beneath ovarian capsule. Most cases are ...
Arul A Sri Kennath J AS Department of Oral and Maxillofacial Pathology, Best Dental Science College, Madurai, Tamil Nadu, - - 2014
Rhabdomyosarcoma is a malignant tumor composed of neoplastic mesenchymal cells, with varying degrees of striated muscle cell differentiation. With most cases occurring in children younger than 10 years, it is remarkably rare in adults. Further in adults, the typical pediatric rhabdomyosarcoma variants (embryonal and alveolar sub-types) occur less frequently and ...
Naik Raghavendra Mahadev RM Department of Oral Medicine and Radiology, Vishnu Dental College and Hospital, Bhimavaram, Andhra Pradesh, - - 2014
Cemento-ossifying fibroma (COF) is classified as a fibro-osseous neoplasm and included among the non-odontogenic tumors derived from the mesenchymal blast cells of the periodontal ligament, with a potential for forming fibrous tissue, cementum and bone, or a combination of such elements. These are slow-growing lesions, and are more frequent in ...
Khera Rachna - - 2014
Clear cell papillary cholangiocarcinoma is a rare variant of intrahepatic cholangiocarcinoma with only nine reported cases in the literature. This tumor needs to be differentiated from clear cell variant of hepatocellular carcinoma and other metastatic clear cell carcinomas. This tumor is known to have better prognosis compared to conventional intrahepatic ...
Sable Mukund N - - 2014
Extra-gonadal malignant transformation of teratoma is rare and there are only a few reports available citing malignancy arising in the non-germ cell components. We hereby report a case of a 35-year-old female, who presented with lower backache with a radiologically identifiable mass lesion in the pre-sacral region. Clinical and radiological ...
Nakanishi Ryota R Department of Clinical Laboratory Medicine, Shiga University of Medical Science Shiga, - - 2014
It is well established that patients with immunosuppression have a higher risk of development of lymphoproliferative disorders (LPDs), and Epstein-Barr virus (EBV) is associated with development of LPDs. Aplastic anemia (AA) is an immune-mediated hematological disorder, and immunosuppression therapy (IST), such as antithymocyte globulin (ATG), is widely used for treatment ...
Anqi Xiao X Sichuan University, West China Hospital, Department of Neurosurgery, Chengdu, P. R. - - 2014
Myeloid sarcoma initially occurring in the sacral canal is often misdiagnosed as other pathological tumors on MRI due to the lack of a definite history or clinical evidence of granulocytic leukemia. Here, we report a case of 24-year-old male patient with myeloid sarcoma misdiagnosed radiologically. On MRI, sacral myeloid sarcoma ...
Applebaum Danielle S - - 2014
Multinucleate cell angiohistiocytoma (MCAH) is a rare, benign vascular proliferation. Fewer than 80 cases have been reported to date, which may relate to under-recognition of this entity. Lesions are commonly asymptomatic and appear as erythematous to violaceous papules on the lower extremities and dorsal hands of middle-aged to elderly women. ...
Jiang Jian J Department of Breast Surgery, the Second Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of - - 2014
In this case study and review, we present a case of a primary small-cell neuroendocrine carcinoma (SCNC) of the male breast. Primary SCNC of the breast is a rare tumor with less than 30 cases reported in the literature. Most cases are found in women. Another exceptional point is that ...
Moraveji S S Department of Internal Medicine, Texas Tech University, Paul L. Foster School of Medicine, 4801 Alberta Avenue, El Paso, TX 79905, - - 2014
We describe a patient with acute leukemia of ambiguous lineage who had trisomy 4 as the sole cytogenetic abnormality. Clinical, pathological, immunophenotypic and molecular features are presented and compared with the previous 4 published cases. Over expression of c-kit, which is localized to chromosome 4, was documented on the leukemic ...
Armengot-Carbo Miquel M Arnau de Vilanova Hospital, - - 2014
Perineuriomas are rare tumors derived from perineural cells usually presenting as a single asymptomatic papule or nodule located on an extremity of an adult. A sclerosing subtype has been rarely described. We report a case of painful sclerosing perineurioma in a 42-year-old woman.
Sahoo Sujit Ranjan SR Department of Oral Pathology, Institute of Dental Sciences, Bhubaneswar, Odisha, - - 2014
Diffuse large B-cell lymphomas (DLBCLs) are defined as neoplasms of large transformed B cells, i.e. with nuclear diameter more than twice that of a normal lymphocyte. These account for 30-40% of all adult non-Hodgkin's lymphomas (NHL). Intraoral lymphomas are relatively rare and often difficult to diagnose in clinical settings. In ...
Ponnam Srinivas Rao SR Department of Oral Pathology, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, - - 2014
Myeloid sarcoma (MS) is a rare extramedullary tumor composed of primitive granulocytic cells. These lesions are commonly associated with other hematologic disorders such as myeloid leukemia and other myeloproliferative neoplasms. Although extremely rare in the oral cavity, this lesion was reported in gingiva, palate, buccal mucosa and extraction sockets. MS ...
Palakshappa Suhasini Gotur SG Department of Oral Pathology and Microbiology, Subharti Dental College, Meerut, Uttar Pradesh, - - 2014
Oncocytic neoplasms comprise a group of rare tumors of salivary glands. Histologically, World Health Organization (WHO) (1991) classified them into three distinct types: Oncocytosis, oncocytoma and oncocytic carcinoma. Oncocytoma is also known by the more descriptive and less confusing terms of oxyphilic adenoma and oxyphilic granular cell adenoma. Oncocytoma is ...
Azin Arash A Faculty of Medicine, University of Toronto, Canada. Electronic address: - - 2014
AML is the most common form of leukemia in adults. In rare circumstances AML may present in the form of extra-medullary disease. Gallbladder infiltration with myeloblasts is rare and only a few cases exist in the literature describing this entity. We present a rare case of AML relapse in the ...
Wang Lei-Ming LM Department of Pathology, Peking University Health Science Center Beijing 100191, China ; Department of Pathology, Capital Medical University, Xuanwu Hospital Beijing 100053, - - 2014
Intraneural perineurioma is a neoplasm of perineurial cells, corresponding to WHO grade I. We present a case of intraneural perineurioma affecting multiple nerves, which usually involved one or two of major nerve trunks in one patient. We describe the clinical presentation, magnetic resonance (MR) neurography characteristics, and pathological characteristics. The ...
Liu Qiang Q Department of General Surgery, 175 Hospital of PLA (Affiliated Dongnan Hospital of Xiamen University) 269 Zhanghua Middle Road, Zhangzhou 363000, Fujian Province, - - 2014
Lipoblastoma is a rare benign mesenchymal tumor that composes of embryonal white fat tissue and typically occurs in infants or young children under 3 years of age. It usually affects the extremities, trunk, head, and neck. The perineum is a rare location with only 7 cases reported in the literature. ...
Bai Yanfeng Y Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou, Zhejiang Province, - - 2014
Human herpesvirus type 6 (HHV-6) has been well described as an agent in immunocompromised hosts, but is a rare cause of acute lymphadenitis in immunocompetent adults. We report an immunocompetent adult with HHV-6-associated acute lymphadenitis. The patient was an elderly man who presented with fever and generalized lymphadenopathy. Microscopically, the ...
Wang Yaya Y Centre of Oncology and Hematology, The First Affiliated Hospital of Guangzhou Medical University Guangzhou, - - 2014
Cases of diffuse large B-cell lymphoma (DLBCL) arising after the initial diagnosis of angioimmunoblastic T-cell lymphoma (AITL) and DLBCL synchronous with AITL have been reported. To date, there is no report on the subsequent development of AITL in patients with DLBCL. Here we presented a rare case of AITL developing ...
Agarwal Shweta S Department of Pathology, University of Oklahoma Health Sciences Center Oklahoma City, OK, - - 2014
Tanycytic ependymoma is the rarest variant of ependymoma and occurs primarily in the spinal cord. Intracranial cases are even rarer. Only 9 ventricular and 5 subcortical tanycytic ependymoma have been reported in the literature. Amongst the 9 ventricular cases, only one tumor arose from the third ventricle. We report here ...
Blackmon Joseph J University of Kansas Medical - - 2014
Basal cell carcinoma (BCC) is the most common malignancy in humans. We present a man with a recurrent BCC of the scalp that presented as an intracranial tumor 18 years after original excision.
Mehta Jaya M JM Division of Endocrinology, Diabetes & Metabolism, Jefferson Medical College of Thomas Jefferson University, 211 South 9th Street, Suite 600, Philadelphia, PA 19107, - - 2014
Objective. To report an unusual case of ovarian Leydig cell hyperplasia resulting in virilization in a postmenopausal woman. Methods. Patient's medical history and pertinent literature were reviewed. Results. A 64-year-old woman presented with virilization with worsening hirsutism, deepening of her voice, male musculature, and male pattern alopecia. Her pertinent past ...
Albino-González Miguel - - 2014
Clear cell carcinoma of the lung is very rare, with few cases reported in the medical literature. Review of case studies show that these tumors have significant variation in clinical outcome, including metastatic disease. We present a very unusual case of primary clear cell lung carcinoma of salivary gland type.
Pemmaraju Naveen N Department of Leukemia, The University of Texas MD Anderson Cancer Center , Houston, TX , - - 2014
Malignant pleural effusions occur in the setting of both solid and hematologic malignancies. Pleural effusion caused by leukemic infiltration is an unusual extramedullary manifestation of acute myeloid leukemia (AML) with fewer than 20 cases reported (1-11). We report a case of pericardial and pleural effusions in a patient with AML ...
Cao Wanli W Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University Shanghai 200025, - - 2014
Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare and recently recognized subtype of renal cell carcinoma (RCC). Apart from the classic morphology comprising conventional three components, there exist a large number of non-classic morphological variants of MTSCC, which make it necessity to differentiate from other RCC. Herein, we ...
Pilichowska Monika M Department of Pathology and Laboratory Medicine and Department of Hematology-Oncology, Tufts Medical Center, Tufts University Medical School, Washington Street 800, Boston, MA 02111, - - 2014
Hairy cell leukemia/lymphoma (HCL) is a rare B-cell neoplasm primarily involving spleen, bone marrow, and blood. However, other sites of primary involvement do occur and can present a diagnostic and therapeutic challenge. We present an unusual case of HCL involving predominantly the breast that was diagnosed as an incidental finding ...
Kumar R - - 2013
Metastatic renal cell carcinoma (RCC) in the nose and paranasal sinuses is very rare. We report an unusual case of metastatic RCC that presented as recurrent epistaxis ten years after curative nephrectomy. The purpose of this report is to draw the attention of clinicians to the possibility of metastatic RCC ...
Xu Sheng-Sheng SS Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address: - - 2013
Intravascular papillary endothelial hyperplasia was a rare benign vascular proliferative process as a result of papillary proliferation of the endothelial cells within the vessels. To our knowledge, we reported the second case occurring in the madibule, and the first reported in 1984 in the literature. We discussed manifestations of multislice ...
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