In China, 78 cases of cutaneous porphyrias, together with 67 cases reported by other clinicians from 1979 to 1990, were reviewed. Of a total of 145 cases, 75.2% were EPP (109 cases), but only 28 cases (19.3%) were PCT. This prevalence differs from that in other parts of the world. ...

We report an unusual case of primary cutaneous mucormycosis caused by Mucor hiemalis Wehmer that occurred in a healthy young girl after an insect bite. The patient had a slowly extending, indurated, erythematous, and scaling eruption on the right cheek. Histologic examination revealed granulomatous dermatitis and characteristic broad, nonseptate, pale-staining ...

Cytomegalovirus infections are a major source of morbidity and mortality in immunocompromised patients. We report a case of cutaneous cytomegalovirus in a patient with the acquired immunodeficiency syndrome, in which routine light microscopy was suggestive but not diagnostic of cytomegalovirus. Immunohistochemical studies of the specimen for cytomegalovirus antigens revealed numerous ...

One hundred fourteen Leishmania isolates from patients with different clinical forms of leishmaniasis in the State of Bahia, Brazil, were characterized by indirect radioimmune binding assay using specific monoclonal antibodies (serodeme analysis). Seventy-five of these isolates were also analyzed by enzyme electrophoresis, based on 11 enzyme loci; parasite species were ...

This study comprised 14 patients from whose skin nontuberculous mycobacteria were recovered. Most clinical manifestations were relatively nonspecific. Various histopathologic patterns were observed in 22 biopsy specimens. Recurrences were common and prolonged treatment was often necessary. Culture of tissue remains the definitive diagnostic procedure. Cutaneous lesions can be the first ...

The case of a 45 year old man with cutaneous polyarteritis nodosa and Raynaud's phenomenon as initial manifestation of the disease is reported. Although peripheral vascular disease is a well characterised extracutaneous manifestation of cutaneous polyarteritis nodosa, to our knowledge this is the first reported case in which Raynaud's phenomenon ...

This article briefly reviews current knowledge about leishmaniasis in Ecuador--proceeding from 1920, when the first human case was described, to the present. Regarding basic conditions, it appears that 14 of Ecuador's 20 provinces have endemic leishmaniasis. Nationally, over 4,000 cases were registered in the 1983-1986 period. Of 260 cases cited ...

The paper reports a case of a 6-year-old boy affected by visceral leishmaniasis. In addition to clinical and anamnestic findings, diagnosis was made on the basis of the rapid increase in the titer of anti-Leishmania antibodies (16-fold), while the marrow smear was negative. A complete recovery was obtained using antimonial ...

A case of erythema elevatum diutinum (EED) closely resembling porphyria cutanea tarda (PCT) is reported. The initial skin biopsies were suggestive for PCT but porphyrin levels in the urine, stool and plasma were normal. A further biopsy from an early cutaneous lesion showed a leucocytoclastic vasculitis with fibrinoid necrosis of ...

We present the case of a 77-year-old female with a rare genital and anoperineal granulomatous cutaneous manifestation resembling cheilitis granulomatosa Miescher. The typical histological findings of epithelioid cell granulomas were localized in the vulva and anoperineal region; the latter manifestation has not yet been described. Based on our personal observations ...

The first comprehensive case report of intraoral xanthomatosis associated with primary biliary cirrhosis is detailed. The lesions were present along the free gingival margin and labial vestibule. Crevicular fluid was noted to be tinged yellow. Generalized cutaneous eruptions were also seen. The xanthomas were attributed to the underlying hyperlipoproteinemia. Advanced ...

Thirty-five percent of 363 melanocytic nevi were found to have a keratotic epithelial architectural pattern that was mostly infundibular and not previously emphasized. Keratotic melanocytic nevi were commonly from the trunk of women, and most were associated with an intradermal melanocytic nevus. The clinical and histopathologic features as well as ...

As many as 40% of all primary cutaneous melanomas can have histologic remnants of nevomelanocytic nevi adjacent to the tumor. There is increasing evidence that dysplastic nevi are at least a clinical marker for melanoma risk. Spitz nevi are not known for such an association, but are noteworthy because of ...

Pachyonychia congenita is a rare genodermatosis characterized by symmetrical thickening and discoloration of the nails with a wedge-shaped, pinched-up, or claw-like appearance. Subungual hyperkeratosis results in a lifting up of the free edge of the nail. Nail changes may be seen alone or in combination with a variety of other ...

Hypomelanosis of Ito is a congenital neurocutaneous syndrome with a particular pattern of swirling hypopigmentation. Multiple extracutaneous abnormalities involving the central nervous system, the eyes, and musculoskeletal structures occur in over two-thirds of the cases. This report describes two patients with typical unilateral cutaneous lesions associated with extracutaneous features, including ...

Cutaneous leishmaniasis is endemic in south central Texas. There have been at least eight cases, four of which have been reported since 1980. An additional case of cutaneous leishmaniasis is reported in a 56-year-old woman from Sandia, Texas. The diagnosis was confirmed by culture of Leishmania mexicana var. mexicana.

Cutaneous mucinosis is an uncommon lesion characterized by mucin accumulation in the dermis. Rarely, mucinosis may arise in the oral cavity; reported cases have been observed in patients older than 16 years. We identified two children younger than 5 years of age with focal mucinosis of the upper aerodigestive tract. ...

Pseudomonas aeruginosa is a frequent pathogen of patients with chronic underlying disease in the hospital environment. This organism is, however, an extremely rare cause of either community-acquired pneumonia in a normal host, metastatic bacterial endophthalmitis or metastatic cutaneous pustules. We report here a case combining these three rare manifestations in ...

A 4-year-old Japanese girl with a nonpigmented nodule on the anterior portion of the palate since birth is described. The overall microscopic appearance of the lesion was very similar to that of Spitz nevus of the skin. Diagnosis of Spitz nevus (mixed epithelioid cell and spindle cell nevus) was made ...

This paper presents analysis of data on 130 cases of oral melanocytic nevi from the files of the University of the Pacific, San Francisco and the University of California, San Francisco. This is the largest detailed series from one geographic location published to date. Nevi of the intramucosal type are ...

All cutaneous nevomelanocytic specimens accessioned for histopathologic examination at Massachusetts General Hospital, Boston, in 1950, 1960, 1970, and 1987 were reviewed. The specimens were categorized as malignant melanoma, acquired or congenital benign nevi, blue nevi, spindle and epithelioid cell nevi, and dysplastic nevi. Other processes such as lentigines were excluded. ...

Although cutaneous larva migrans is more commonly seen in the southeastern US and tropical regions of the world, patients with such parasitic involvement may present in other non-endemic areas for various reasons, particularly travelers returning from tropical vacations. Awareness of the clinical presentation and symptomatology of cutaneous larva migrans is ...

Woolly hair nevus is a rare, nongenetically determined condition in which unruly and tightly curled hair is localized on one or several areas of the scalp. We report the first case of woolly hair nevus with onset during adolescence. Marked improvement was evident 5 years after onset. Light microscopic examination ...

The origins of primary cutaneous amyloid have been investigated and several possibilities are proposed. We investigated here several cases by electron microscopy and found in all cases characteristic filamentous changes which were identical with amyloid structures in the collagen bundles. These observations suggested a possible pathway of cutaneous amyloid formation ...

Lichen planus is a mucocutaneous disorder well known to both dermatologists and dentists. Traditional belief holds that oral lichen planus predisposes to the development of squamous cell carcinoma of the oral cavity. We present a case that illustrates such a malignant transformation in a patient who smoked and had actinically ...

We report a case of two neuromuscular choristomas occurring in separate cutaneous locations in a healthy 3-month-old infant. Both lesions had an identical histologic appearance and were composed of mature skeletal muscle cells admixed with nerve fibers. In all previous reports, neuromuscular choristoma has arisen in association with a major ...

The subepidermal calcified nodule (SNC), included under the idiopathic cutaneous calcifications, is an infrequent cutaneous process. We report a new case localized on the chin of an 18 month old child. We review the concept gathered from previous literature and we post the possible role which the mast cell may ...

Lichen planus is a relatively common inflammatory dermatosis with characteristic lesions affecting the skin, nails and mucous membranes. Nail changes are present in approximately 10% of patients and can occasionally occur in the absence of skin involvement. The association of lichen planus with primary biliary cirrhosis is now well recognized. ...

A possible association between mucocutaneous lichen planus and chronic liver disease has been previously postulated in the medical literature. Despite the frequency with which lichen planus occurs in the oral cavity, little mention of such a relationship has been made in the dental literature. A case of lichen planus occurring ...

Acral persistent papular mucinosis has recently been proposed as a distinct form of cutaneous mucinosis. We describe a patient and review the literature. We conclude that acral persistent papular mucinosis is a distinct clinical entity, clearly separable from most other forms of cutaneous mucinosis except for one variant of lichen ...

A case of urogenital myiasis in a patient with transverse myelitis is reported from Imphal, Manipur, India. The larvae of Megaselia scalaris Lowe were recovered repeatedly from the urine of the patient and were reared to adult to facilitate identification. This is the first known case of urinary myiasis caused ...

We report a case of Spitz nevus of the bulbar conjunctiva in a 15-year-old boy. Clinically, the lesion was juxtalimbic, nodular, red, and 6mm in diameter. Only histologic examination provided the diagnosis. Perusal of the literature revealed seven cases of Spitz nevus of the conjunctiva, but for some of them ...

A recent case of cutaneous segmental neurofibromatosis provided the opportunity to review the literature to better understand this rare disease. This cutaneous form of the disease usually appears only on the skin, without other systemic involvement; it is not inherited. Only 19 additional cases in the English literature could be ...

Focal acantholytic dyskeratosis (FAD) is a distinctive histologic pattern characterized by suprabasilar clefts surrounding dermal papillae (villi), acantholytic and dyskeratotic cells at all levels of the epidermis, hyperkeratosis, and parakeratosis. The features of FAD are typically seen in Darier's disease, warty dyskeratoma, and transient acantholytic dermatosis; they are also present ...

Erythropoietic protoporphyria (EPP), a recently described form of porphyria, often remains unrecognized. We report the case of a 7-year-old girl admitted for investigation of photosensitivity since the age of 18 months without any significant objective cutaneous lesions. Clinical features, quantitative determinations of porphyrins in blood, urine and stools, ferrochelatase activity ...

The condition known as actinic lichen planus is believed to be a particular variant of lichen planus which occurs on light-exposed areas. Synonyms include lichen planus tropicus, lichen planus subtropicus, lichen planus in subtropical countries, lichenoid melanodermatitis, and lichen planus atrophicus annularis. The majority of reported cases are from the ...

We have previously described a kindred with hereditary medullary thyroid carcinoma and pheochromocytoma (multiple endocrine neoplasia type 2A [MEN 2A]) with localized pruritic cutaneous manifestations present only in affected members. Although the initial skin biopsies reported did not show amyloidosis, subsequent skin biopsy results reported here have demonstrated amyloid which ...

A 51-year-old immunosuppressed man presented with ulcerations of the abdominal wall. Biopsy of the ulcer margin was necessary for the diagnosis of cutaneous cryptococcosis. Since a variety of opportunistic organisms can present with non-specific cutaneous lesions, these infections must be ruled out by tissue diagnosis of all immunosuppressed patients. A ...

Benign acquired melanocytic nevi usually display an even and uniform architecture and coloration easily recognized by the dermatologist. The cockarde nevus, a variant of the melanocytic nevus, is an exception. It displays a targetlike morphology with histologic characteristics of a compound nevus. We believe because the lesion has been rarely ...

Two unrelated young women with papular elastorrhexis have recently been seen at the University of Iowa Hospitals and Clinics. This entity, recently described in a single patient, is a distinct variant of a connective tissue nevus. Although the histologic features of papular elastorrhexis may mimic those of other connective tissue ...

A report of a patient with the rare syndrome of sinus histiocytosis with massive lymphadenopathy is presented here. This patient is unusual in several respects, including his longevity after diagnosis, the presence of a benign monoclonal gammopathy, and the characterization of his cutaneous infiltrates by immunofluorescent monoclonal antibody markers. A ...

We report the clinical features of 62 consecutive patients with lichen planus observed in 18 months. The largest number of cases occurred between 50 and 70 years of age. Thirty-four patients had lichen planus only. In the remainder, lichen planus was associated with chronic liver diseases (16 cases), immune-related disorders ...

The first authentic case of African histoplasmosis from the Sudan is reported. The patient came from Dindir, along the southern part of the Blue Nile River. He had cutaneous and visceral leishmaniasis as well as the cutaneous form of African histoplasmosis. The latter was proved by culture and histopathology to ...

Cutaneous horns of the penis are hyperkeratotic lesions of the skin which arise secondary to chronic irritation. Treatment is local excision with removal of a broad base. Examination of the base is important to rule out carcinoma as the underlying cause of the lesion. A case report is presented and ...

Because of their dark color and hunting habits, wolf spiders (Lycosidae) are often confused with the much more dangerous brown recluse spider (Loxosceles reclusa). Unlike the brown recluse spider, wolf spider envenomation seldom causes cutaneous necrosis or systemic symptoms. In this report, two documented cases of wolf spider bites are ...

A case of high-grade malignant extramedullary plasmacytoma (EMP), unusual in its initial cutaneous localization and major involvement in the central nervous system rapidly resulting in death, is reported. Light- and electron-microscopic studies of a skin nodule revealed a high proportion of immature and mature plasmacytes. Immunohistological study revealed that both ...

Leishmaniasis was diagnosed by demonstrating amastigotes of Leishmania from dermal lesions on the ear of a male long-haired domestic cat from Uvalde, Texas. Leishmania from the cat were propagated in Syrian hamsters, bovine macrophages, and in NNN medium. The organism, in the L. mexicana complex, is apparently the same as ...

A case report of a cutaneous larva migrans caused by the nematode, Gnathostoma spinigerum, in which the worm was visualized at surgery and successfully removed, is presented. To the best of our knowledge, this is the second case of documented subcutaneous gnathostomiasis in the Western Hemisphere and the first in ...

Two patients with schistosomiasis of the skin were seen at the Ahmadu Bello University Teaching Hospital, Kaduna, Northern Nigeria, between June 1978 and December 1980. The first case was not suspected on clinical grounds, but was diagnosed only after terminally-spined ova of Schistosoma haematobium were found in histological sections of ...

We reviewed longitudinal nail biopsies performed at Henry Ford Hospital on patients with acquired nail dystrophies to see whether the procedure did, indeed, provide useful diagnostic information and to see which microscopic features were most helpful in histopathologic diagnosis. Clinical diagnoses included psoriasis, lichen planus, Darier's disease, isolated longitudinal defects, ...