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Peroutka Stephen J - - 2013
An annual review of the status of recently completed and ongoing major clinical trials involving common headache disorders is presented. The review will focus on multicenter trials of new therapies as well as novel formulations of previously approved therapeutics. The article also presents a tabulated summary of the major therapeutic ...
Gundannavar Gayatri - - 2013
This case report presents two female patients whose chief complaint was discoloration of teeth. On careful clinical examination it was found that the patients had features of amelogenesis imperfecta and localised aggressive periodontitis. This article will give an insight of clinical and radiographic features of amelogenesis imperfecta with localised aggressive ...
Rao G Raghurama - - 2013
Disseminated blastomycosis is rare in India, particularly in the pediatric population. We discuss the clinical picture, progress and outcome of disseminated blastomycosis in a 4-year-old child. We also present a brief review of the literature focussing on the scenario of blastomycosis in India.
Mahlknecht Ulrich - - 2013
The editors of Clinical Epigenetics would like to thank all our reviewers who have contributed to the journal in volume 4 (2012).
Edinger Tracy T Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR, - - 2013
A literature search to identify relevant studies is one of the first steps in performing a systematic review (SR) in support of evidence-based medicine. To maximize efficiency, the search must find practically all relevant studies and retrieve few that are irrelevant; however, this level of precision is seldom attained. Therefore, ...
Iannace Carlo - - 2013
Benign lymphoreticulosis (cat scratch disease, CSD) may have a clinical course that varies from the most common lymphadenitis localized in the site of inoculation, preceded by the typical "primary lesion," to a context of severe systemic involvement. Among these uncommon clinical aspects, there is mammarian granulomatous lymphadenitis which may appear ...
Doshi Peter - - 2013
To explore the structure and content of a non-random sample of clinical study reports (CSRs) to guide clinicians and systematic reviewers. We searched public sources and lodged Freedom of Information requests for previously confidential CSRs primarily written by the industry for regulators. CSRs reporting sufficient information for extraction ('adequate'). Presence ...
Versiani Ane Helena Valle AH Universidade Federal de São Paulo, São Paulo, Brazil. - - 2013
CONTEXT AND OBJECTIVE Evidence-based clinical practice emerged with the aim of guiding clinical issues in order to reduce the degree of uncertainty in decision-making. The Cochrane Collaboration has been developing systematic reviews on randomized controlled trials as high-quality intervention study subjects. Today, physiotherapy methods are widely required in treatments within ...
Vasconcelos Carvalho Marianne - - 2013
Ectodermal dysplasias are a large group of syndromes characterized by anomalies in the structures of ectodermal origin. There are 2 major types of this disorder, based on clinical findings: hypohidrotic ectodermal dysplasia and hidrotic ectodermal dysplasia. This clinical classification is very important because clinical professionals involved with this disease need ...
Walker Alison A Division of Hematology and Oncology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, - - 2013
Acquired chromosome abnormalities in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are among the most valuable determinants of diagnosis and prognosis. In search of new recurrent balanced translocations, we reviewed the Cancer and Leukemia Group B (CALGB) cytogenetics database containing pretreatment and relapse karyotypes of 4,701 adults ...
Esquenazi Alberto - - 2012
Botulinum neurotoxin (BoNT) can be injected to achieve therapeutic benefit across a large range of clinical conditions. To assess the efficacy and safety of BoNT injections for the treatment of spasticity associated with the upper motor neuron syndrome (UMNS), an expert panel reviewed evidence from the published literature. Data sources ...
Wallace John - - 2012
Context  The increased uptake of evidence from systematic reviews is advocated because of their potential to improve the quality of decision making for patient care. Systematic reviews can do this by decreasing inappropriate clinical variation and quickly expediting the application of current, effective advances to everyday practice. However, research suggests ...
Wiffen Philip J - - 2012
ABSTRACT The Cochrane Library of Systematic Reviews is published quarterly as a DVD and monthly online. The July 2012 issue (3rd DVD for 2012) contains 5131 complete reviews, 2235 protocols for reviews in production, and 18,306 short summaries of systematic reviews published in the general medical literature. In addition, there ...
Bakota Bore - - 2012
Treatment of a mangled lower extremity represents a major challenge. The decision whether to amputate or attempt reconstruction is currently based upon surgical evaluation. The aim of this paper is to propose a new approach to surgical evaluation based on scoring systems, local clinical status of the patient as well ...
J Burke Christopher - - 2012
Spondylolisthesis is often poorly understood by clinicians and radiologists. Incorrectly perceived as being chiefly related to pars defects, in reality spondylolisthesis has multiple aetiologies with differing clinical implications. This article addresses the salient radiological findings in the assessment of spondylolisthesis.
Miguel A I M AI Ophthalmology Department, Central University Hospital of Coimbra, Coimbra, Portugal. - - 2013
(1) To describe the clinical characteristics of Purtscher and Purtscher-like retinopathies, including etiologies, fundoscopic signs, results of complementary investigation, treatments, and outcomes. (2) To compare visual acuity (VA) of patients receiving corticosteroids for PuR compared with observation. Systematic review of several databases (1980-2010): Medline, EMBASE, ISI, EBSCO, Science Direct and ...
Petrovic Igor N IN Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, 1 Wakefield St, London, WC1N 1PJ, UK. - - 2013
The classical presentation of sporadic Creutzfeldt-Jakob disease (sCJD) is rapid progressive dementia often associated with myoclonus and ataxia followed by death in less than a year from diagnosis. The few patients in the literature who presented with parkinsonism and who were suspected to have progressive supranuclear palsy (PSP) all ran ...
Rogan Slavko - - 2013
Hamstring injuries are common among football players. There is still disagreement regarding prevention. The aim of this review is to determine whether static stretching reduces hamstring injuries in football codes. A systematic literature search was conducted on the online databases PubMed, PEDro, Cochrane, Web of Science, Bisp and Clinical Trial ...
Lombardo Luca - - 2012
Although evident advances have certainly been made, not only in the use of brackets, but also in the mechanics and type of wires and accessories employed, the most recent systematic review of the literature on this topic stated despite claims regarding the clinical superiority of self-ligating brackets, evidence is generally ...
Boutsioukis C - - 2012
The aim of the present study was to conduct a systematic review and critical analysis of published data on irrigant extrusion to identify factors causing, affecting or predisposing to irrigant extrusion during root canal irrigation of human mature permanent teeth. An electronic search was conducted in Cochrane Library, LILACS, PubMed, ...
Cardin F - - 2012
Background and Aims : Chronic mesenteric ischemia in older patients is a challenge for the physician because it coincides with a vague and non-specific clinical presentation with abdominal pain. It can frequently cause diagnostic errors lead to legal consequences. The aim of this work was to evaluate the literature on ...
Duqum Ibrahim - - 2012
This literature review sought to determine the advantages and disadvantages of denture adhesive use among complete denture patients. Manuscripts were obtained by searching the National Library of Medicine's PubMed database, Cochrane Collaboration Library, ADA Center for Evidence-Based Dentistry website, and EMBASE database. A total of 85 abstracts were reviewed, and ...
Iglesias-Martin Fernando - - 2012
To evaluate the etiopathogenesis, clinical features, therapeutic options, and surgical approaches for removal of ectopic third molars in the mandibular condyle. MEDLINE search of articles published on ectopic third molars in the mandibular condyle from 1980 to 2011. 14 well-documented clinical cases from the literature were evaluated together with a ...
Iorio Matthew L ML Washington, D.C. From the Department of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, - - 2012
Use of biologically engineered acellular dermal matrices in the upper and lower extremities is increasingly recognized as a means of achieving definitive healing in the setting of both acute and chronic injuries but data and evidence supporting their use are limited. The authors performed this systematic review to identify all ...
Franks Andrea S - - 2012
To review the evidence surrounding a potential association between liraglutide and pancreatitis. A literature search was conducted in MEDLINE (1948-July 12, 2012) and EMBASE (1974-week 27, 2012) using the search terms pancreatitis, liraglutide, and glucagon-like peptide 1/adverse effects. Reference citations from identified publications were reviewed. The manufacturer was contacted and ...
Teune Mj - - 2012
Please cite this paper as: Teune M, van Wassenaer A, Malin G, Asztalos E, Alfirevic Z, Mol B, Opmeer B. Long-term child follow-up after large obstetric randomised controlled trials for the evaluation of perinatal interventions: a systematic review of the literature. BJOG 2012; DOI: 10.1111/j.1471-0528.2012.03465.x. Background  Although the hope is ...
Brightwell Robert E - - 2012
BACKGROUND: There has been a trend towards favouring endovascular repair for much acute aortic pathology. We undertook a review of the literature to determine if an endovascular approach could complement the traditional treatment of aortocaval fistula (ACF), a rare complication of abdominal aortic aneurysm. METHODS: A literature search was undertaken ...
Haynes M J - - 2012
Strokes, typically involving vertebral artery dissection, can follow cervical spinal manipulative therapy, and these types of stroke occur rarely. There is disagreement about whether a strong association between neck manipulation and stroke exists. An earlier systematic review found two relevant studies of association that used controls, which also discussed the ...
Hirano Stefanie A - - 2012
  To review the literature on atopic dermatitis (AD) clinical trials published in the United States between 2000 and 2009 to examine the representation of racial and ethnic minorities in those trials and determine the extent to which investigators reported on demographic variables and performed a subanalysis. A PubMed search ...
Rosman Ageeth N - - 2012
Objective External cephalic version (ECV) is a safe and effective intervention that can prevent breech delivery, thus reducing the need for cesarean delivery. It is recommended in national guidelines. These guidelines also mention contraindications for ECV, and thereby restrict the application of ECV. We assessed whether the formulation of these ...
Layfield Lester J - - 2012
BACKGROUND: The College of American Pathologists (CAP) recognizes the need for clinical data in the interpretation of specimens submitted for histopathologic evaluation. Anecdotal evidence indicates that clinician compliance with requests for clinical history is variable. DESIGN: Quality assurance data from August 1, 2010 to September 31, 2011 were searched for ...
Newman Simon D S SD Imperial College London, Level 7 East Wing, Charing Cross Hospital, Fulham Palace Road, London, W6 8RF, UK. - - 2013
The Ligament Augmentation and Reconstruction System (LARS) is a third generation of synthetic ligament, designed to overcome the issues of graft failure and synovitis which led previous generations of synthetic ligaments to fall out of favour. The theoretical benefits of LARS are appealing but this has not led to widespread ...
Hartling Lisa - - 2012
OBJECTIVES: To assess the reliability of the Cochrane Risk of Bias (ROB) tool between individual raters and across consensus agreements of pairs of reviewers and examine the impact of study-level factors on reliability. STUDY DESIGN AND SETTING: Two reviewers assessed risk of bias for 154 randomized controlled trials (RCTs). For ...
Yusuf Syed Wamique - - 2012
Endocarditis and myocarditis are conditions seen worldwide with considerable morbidity and mortality. Despite the improvements in diagnostic technologies, clinical diagnosis remains crucial as only prompt recognition will lead to appropriate investigations and timely intervention, which may be life saving. In this review, the authors provide a concise overview of endocarditis ...
Jhamb Aakarsh - - 2012
Fibrous dysplasia can present clinically in varied forms which may appear as collision of different pathologic processes. We report a rare case of craniofacial fibrous dysplasia with coexisting epithelial lined cyst and superimposed osteomyelitis with sequestrum formation. Its clinical features and management with possible hypotheses are described along with the ...
Wiffen Philip J - - 2012
ABSTRACT The Cochrane Library of Systematic Reviews is published quarterly as a DVD but monthly online. The April 2012 issue (second DVD for 2012) contains 5045 complete reviews, 2182 protocols for reviews in production, and 17,084 short summaries of systematic reviews published in the general medical literature. In addition, there ...
Littlewood Chris - - 2012
The systematic review has become an increasingly popular method of synthesizing findings on a topic in order to inform clinical practice, commissioning of care, and future research. A central component of the systematic review is an assessment of study quality or risk of bias, i.e. an assessment of how near ...
Jean Sherrie M - - 2012
Over a 5-y period, 3 chimpanzees at our institution experienced cerebrovascular accidents (strokes). In light of the increasing population of aged captive chimpanzees and lack of literature documenting the prevalence and effectiveness of various treatments for stroke in chimpanzees, we performed a retrospective review of the medical records and necropsy ...
Ha Kee-Yong - - 2012
Metastatic spine disease (MSD) is a complex disease entity requiring multi-discipline and multi-modality approach to obtain the most reasonable clinical outcomes. As one of these trials, radiofrequency ablation (RFA) has been tried. Here, we describe four cases of metastatic spine lesions (2 hepatomas, 1 lung cancer, 1 breast cancer) that ...
Kumar Mani Kant - - 2012
Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare neurodegenerative disease seen mainly in the Aggarwal community in India. It is characterized by early-onset macrocephaly with mild motor developmental delay, gradual onset ataxia, spasticity, seizures and usually late onset mild cognitive deterioration. Very few familial cases of MLC have been ...
Sugarman Alan - - 2012
Despite a growing body of clinical literature advocating the thoughtful and judicious use of self-disclosure in psychoanalysis, there remains a reflexive reluctance to intervene in this way by many analysts of various theoretical persuasions. Why is this the case? Four motives for this reflexive reluctance to self-disclose are discussed: (1) ...
Lobb Ryan - - 2012
The aim of this systematic review of systematic reviews was to critically appraise systematic reviews on Anterior Cruciate Ligament (ACL) reconstruction rehabilitation to determine which interventions are supported by the highest quality evidence. Electronic searches were undertaken, of MEDLINE, AMED, EMBASE, EBM reviews, PEDro, Scopus, and Web of Science to ...
Oomens Marjolijn A E - - 2012
Controversy exists about the efficacy of antibiotic prophylaxis in preventing complications after lower third molar surgery. For evidence-based recommendation, a review was performed on clinical trials reporting the use of antibiotic prophylaxis compared with no treatment or placebo with "infection" as outcome. Useful studies were identified using Embase, Cochrane, and ...
Pillai Gopal S - - 2012
Intraocular gnathostomiasis is a rare parasitic infection caused by the third-stage larvae of spiruroid nematode Gnanthostoma spp. seen mostly in tropical and subtropical regions. It is a food-borne zoonosis caused by ingestion of raw or undercooked freshwater fish, amphibians, reptiles, birds, and mammals, all of which are known to harbor ...
Kumar Sumir - - 2012
The Bardet-Biedl syndrome (BBS) is a rare ciliopathic human autosomal-recessive disorder, affecting multiple organ systems. Less than 15 cases have been reported from India. The authors present a classical case of BBS presenting to dermatology outpatient with hypogonadism and features such as marked central obesity, retinal dystrophy, polydactyly, structural renal ...
Senthilkumaran Subramanian - - 2012
We report a case of gas gangrene (GG) in a non-diabetic HIV seronegative man who died within 60 hours following an intramuscular injection in rural India. The occurrence of GG after intramuscular injection is rare and only a few cases have been reported in the published literature.
Poetker David M - - 2012
BACKGROUND: Corticosteroids are a mainstay of treatment in the management of sinonasal inflammatory disease. Despite their common use, many practitioners are not well versed in their potential complications or the medico-legal ramifications of their use. The objectives of this review were to outline the existing data of the medico-legal implications ...
Meerpohl Joerg J - - 2012
[This corrects the article on p. e35732 in vol. 7.].
Turner Lucy L Ottawa Hospital Research Institute, Ottawa, Canada. - - 2012
An overwhelming body of evidence stating that the completeness of reporting of randomised controlled trials (RCTs) is not optimal has accrued over time. In the mid-1990s, in response to these concerns, an international group of clinical trialists, statisticians, epidemiologists, and biomedical journal editors developed the CONsolidated Standards Of Reporting Trials ...
Rubin Mark N MN Department of Neurology, Mayo Clinic Rochester, MN, - - 2012
The use of two-way audio-visual technology for delivery of acute stroke is supported by a well established literature base. The use of telemedicine for general neurologic consultation has been reported across most subspecialties within the field, but a comprehensive systematic review of these reports is lacking. To conduct a systematic ...
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