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Das Siddhartha S Department of Forensic Medicine & Toxicology, JIPMER, Puducherry, 605006, - - 2014
Cleistanthus collinus is an extremely toxic plant poison. We report a case of suicidal ingestion of boiled water decoction of C. collinus where the patient presented with abdominal pain and giddiness. There was persistent metabolic acidosis and fluctuation in the level of serum potassium. The ECG changes indicated a probable myocardial ...
van Hattem S S Department of Dermatology, Reference center for cutaneous adverse reactions, University Medical Center Groningen, University of Groningen, Groningen, - - 2014
Acute Generalised Exanthematous Pustulosis (AGEP) and Stevens Johnson syndrome (SJS)/Toxic Epidermal Necrolysis (TEN) are rare but severe cutaneous adverse drug reactions. Especially in TEN, large areas of the skin and mucosae may become detached. Although AGEP and SJS/TEN are distinct entities with a different clinical picture, pathogenesis, prognosis, and treatment, ...
Baccaro Leopoldo M LM From the *Department of General Surgery, Easton Hospital, Pennsylvania; †West Virginia School of Osteopathic Medicine, Lewisburg; and ‡Lehigh Valley Hospital, Allentown, - - 2014
The aim of this study was to briefly review toxic epidermal necrolysis syndrome (TENS) and Steven Johnson Syndrome (SJS), as well as describe the unique complication of ureteral perforation. A case of ureteral perforation in an 18-year old woman with TENS was documented and reviewed. In addition to studying this ...
Dubey Divyanshu D Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas, - - 2014
Para-dichlorobenzene (PDCB) is an active ingredient of mothballs, deodorizers and fumigants. Due to the easy availability of this chemical, there is a considerable risk for accidental or intentional toxic exposure. Recently, multiple cases of PDCB toxicity due to mothball ingestion were reported. PDCB toxicity can affect multiple organ systems including ...
Smith Hannah H Purdue University College of Pharmacy, West Lafayette, IN, - - 2014
To report the case of a patient who presented with chronic symptoms attributable to dronedarone-induced digoxin toxicity. A review of the literature is also provided. This case report details a case of a 77-year-old male patient who presented to the hospital with multiple ambiguous symptoms that lasted several weeks. The ...
Mahar Patrick D PD Victorian Adult Burns Service, The Alfred Hospital, Melbourne, Victoria, Australia; Department of Dermatology, The Alfred Hospital, Melbourne, Victoria, Australia; Department of Surgery, School of Medicine, Faculty of Health, Deakin University, Victoria, Australia. Electronic address: - - 2014
Toxic epidermal necrolysis (TEN) is a rare condition characterised by mucocutaneous exfoliation of greater than 30% total body surface area (%TBSA), increasingly being treated in burns centres. The rate of mortality varies significantly in the literature, with recent prospective studies in non-burns centres reporting percentage mortality of approximately 45%. We ...
Wade James W JW From the Plastic Surgery in the Department of Surgery, LSU Health Sciences Center, New Orleans, - - 2014
After an accepted technique of abdominoplasty, a 66-year-old woman developed Clostridium difficile-associated diarrhea, leading to toxic megacolon and subsequent subtotal colectomy. The presumed etiology is chronic use of a proton pump inhibitor. This was addressed in a 2012 "white paper" warning issued by the Food and Drug Administration. This article ...
Lyros E E Department of Neurology, University of the Saarland, Homburg, Germany. Electronic address: - - 2014
Capecitabine, a 5-fluorouracil (5FU) pro-drug, is increasingly used in breast and gastrointestinal cancers due to its more convenient oral route of administration when compared to 5FU. Despite its widespread use, there are only a few reports on capecitabine CNS toxicity, while the pathogenic basis of such toxicity remains unclear. A ...
Graeme Kimberlie A KA Banner Good Samaritan Regional Medical Center, Phoenix, AZ, USA, - - 2014
Approximately 100 of the known species of mushrooms are poisonous to humans. New toxic mushroom species continue to be identified. Some species initially classified as edible are later reclassified as toxic. This results in a continually expanding list of toxic mushrooms. As new toxic species are identified, some classic teachings ...
Toh James Wei Tatt - - 2014
Background: The objective of this review article and case report was to investigate the effectiveness of high-dose sucralfate on severe life-threatening 5-fluorouracil (5-FU) gut toxicity, with reference to, but not limited to dihydropyrimidine dehydrogenase (DPD) deficiency. Methods: A search was conducted on PubMed from 1950 to July 2013 for original ...
Wilson Natasha J NJ Sansom Institute for Health Research, University of South Australia, Adelaide, Australia. Electronic address: - - 2014
Consumption of amphibian eggs and larvae by crayfish has been widely reported despite many amphibians being unpalatable and/or toxic to other predators. The aim of this review was to gather information regarding the consumption and/or avoidance of toxic amphibians by these omnivores. We then appraised the extent of toxin consumptive ...
Rossignol D A DA Family Medicine, Rossignol Medical Center, Irvine, CA, - - 2014
Although the involvement of genetic abnormalities in autism spectrum disorders (ASD) is well-accepted, recent studies point to an equal contribution by environmental factors, particularly environmental toxicants. However, these toxicant-related studies in ASD have not been systematically reviewed to date. Therefore, we compiled publications investigating potential associations between environmental toxicants and ...
Aghabiklooei A A Department of Forensic Medicine, Iran University of Medical Sciences, Tehran; Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran. - - 2014
Intentional acute toxicity by colchicine is not common but accompanies a high rate of complications and mortality. It is generally assumed to be an emergency in clinical toxicology. Rapid diagnosis and treatment can prevent death. The most common causes of death in this toxicity are acute cardiac failure, shock, and ...
Leeaphorn Napat - - 2013
Granulomatous interstitial nephritis (GIN) is a rare histologic disease. Various causes have been reported in the literature, including drugs, sarcoidosis, and infections. Other incidents have no discernible cause and are identified as idiopathic. We report a 68-year-old white man who presented with acute kidney injury and was given a diagnosis ...
Rao Deepa B - - 2013
This review article is designed to serve as an introductory guide in neuroanatomy for toxicologic pathologists evaluating general toxicity studies. The article provides an overview of approximately 50 neuroanatomical subsites and their functional significance across 7 transverse sections of the brain. Also reviewed are 3 sections of the spinal cord, ...
Kakar Rohit - - 2013
A 91-year-old female presented with widespread skin sloughing and bullae clinically mimicking toxic epidermal necrolysis (TEN). The patient was on multiple antibiotics, including vancomycin and piperacillin/tazobactam. Histopathology and direct immunofluorescence were consistent with a diagnosis of linear IgA bullous disease (LABD). In a PubMed review of the literature from 1975 ...
Cockerill Patrick A - - 2013
Several medications or their metabolites have been associated with urolithiasis, although overall they remain an infrequent cause of urolithiasis. Guaifenesin stones were originally reported as complexed with ephedrine, and subsequent reports have demonstrated pure guaifenesin stones, occurring after long term abuse. We report a case of a 23-year-old male who ...
Rund B R - - 2013
Since the neurotoxicity hypothesis was launched in 1991, it has generated a great deal of interest and given rise to several studies investigating the validity of the hypothesis that being psychotic has a toxic effect on the brain. The toxicity argument is used to justify early treatment. This review attempts ...
Wahba Mervat - - 2013
Asterixis has been reported as a side effect of toxic and metabolic abnormalities. The current literature contains very little evidence of gabapentin-related neurotoxicity. Our observations reveal that neurotoxic side effects of gabapentin use may be seen even when dose adjustments are made for patients with mild-to-moderate renal dysfunction. Clinical vigilance ...
Spaulding Adam R AR Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, - - 2013
SUMMARY This review begins with a discussion of the large family of Staphylococcus aureus and beta-hemolytic streptococcal pyrogenic toxin T lymphocyte superantigens from structural and immunobiological perspectives. With this as background, the review then discusses the major known and possible human disease associations with superantigens, including associations with toxic shock ...
Hamilton Gavin M - - 2013
Stevens Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare debilitating mucocutaneuous diseases most commonly associated with severe drug reactions. A review of SJS/TEN cases was undertaken to describe the causes, patient characteristics, treatment, and outcome in children affected at a large tertiary pediatric hospital. A retrospective chart review ...
Beuhler Michael C - - 2013
The objectives of this study were to present and explore the clinical presentation of the increasingly common pediatric exposure to the widely available single-use laundry packets or "laundry pods." This is a case report of 4 pediatric patients with significant toxicity due to laundry pod detergent exposure and a review ...
Tönnesmann Ernst - - 2013
Abstract Chloroquine and hydroxychloroquine are still used for the prevention and treatment of malaria. Moreover, they are experiencing a renaissance in the long-term therapy of connective tissue diseases (particularly in systemic lupus erythematosus). They induce a lysosomal dysfunction with an accumulation of pathologic metabolic products, which can be seen in ...
Heninger Michael - - 2013
Methamphetamine is a synthetic stimulant that can adversely affect the central nervous system and the immune system. Through various mechanisms, methamphetamine is toxic to neurons, endothelial cells, lymphocytes, granulocytes, and macrophages resulting in systemic damage. Reported is the sudden demise of an otherwise healthy 31-year-old woman with a history of ...
Alahmadi Tahani A - - 2013
Lisuride Maleate (Dopergin) is semi synthetic ergot alkaloid used for a variety of medical conditions. It is licensed for use in Canada, EU and Middle East countries and is marketed by various drug companies. There are no reported cases of lisuride toxicity in the literature on Google Search or Pub ...
Cline J Mark - - 2013
This short review is derived from the peer-reviewed literature and the experience and case materials of the authors. Brief illustrated summaries are presented on the gross and histologic normal anatomy of rodent and macaque placentas, including typical organ weights, with comments on differences from the human placenta. Common incidental findings, ...
Woytowish Melanie R - - 2013
OBJECTIVE:To evaluate and review the literature surrounding serotonin toxicity in patients receiving linezolid and determine the clinical relevance of this reaction.DATA SOURCES:Literature was accessed via MEDLINE/PubMed and Google Scholar (both through February 2013) using the search terms linezolid, serotonin syndrome, serotonin toxicity, and adverse reaction.STUDY SELECTION AND DATA EXTRACTION:Relevant case ...
Shivanthan Mitrakrishnan Chrishan - - 2013
This case series details clinical observations in 7 survivors of accidental hydrogen sulphide inhalation toxicity at a petroleum refinery in Sri Lanka. One survivor developed status epilepticus and severe neurotoxicity whilst another survivor developed delayed respiratory failure; both patients required intensive care management. One victim manifested mild bronchospasms in the ...
Mohyuddin Ghulam Rehman - - 2013
A commonly prescribed drug for Rheumatoid Arthritis (R.A) and Inflammatory Bowel Disease (IBD) treatment, Sulfasalazine can occasionally cause lung toxicity such as interstitial pneumonitis and eosinophilic pneumonias. We report a case of a 46 year old female being treated with Sulfasalazine for Ulcerative Colitis, who developed shortness of breath and ...
Raj Rishi - - 2013
Background: Leflunomide, a disease modifying anti-rheumatic drug in use since 1998, causes interstitial lung disease (ILD) and other pulmonary complications. Methods: We undertook a systematic review of literature of PubMed (March 2013) to identify the published literature pertaining to pulmonary toxicity associated with leflunomide. Results: We identified 41 relevant articles ...
Kim Randie R New York University School of - - 2013
A 64-year-old man presented with a three-year history of an enlarging, pruritic, linear, verrucous plaque on his left lower extremity. Histopathologic examination was consistent with a verrucous epidermal nevus, which is a benign epidermal hamartoma, most commonly observed in the pediatric population. Verrucous epidermal nevi are often refractory to treatment ...
Goswami Mridula - - 2012
Sodium hypochlorite is widely used in dentistry as an intra-canal irrigant, for debridement and to disinfect root canals. Although it is considered to be safe, serious mishap can result from its inappropriate use, and this has been reported infrequently in the literature. Two unusual cases of sodium hypochlorite toxicity and ...
Nacca Nicholas - - 2012
A known complication of Amiodarone therapy is Amiodarone induced Pulmonary Toxicity (APT). Several features of this adverse effect make it difficult to diagnosis and treat. The case of a 63-year-old male with classic radiographic and histologic findings of APT is discussed. Clinical presentation, pathophysiology, diagnostic findings, and treatment strategies are ...
Patterson Jacqueline - - 2012
An expert peer consultation panel reviewed a report by the PAC Analysis Task Group, which hypothesized that systemic, developmental, and reproductive toxicity observed in repeated-dose dermal toxicity studies was related to polycyclic aromatic compound (PAC) content. Peer consultations seek to solicit scientific and technical input from experts on the scientific ...
Kreft Burkhard - - 2012
  Stevens-Johnson syndrome and toxic epidermal necrolysis are some of the most serious, usually drug-induced, skin reactions. We report a case of severe toxic epidermal necrolysis in a child, which in addition to ophthalmic sequelae, caused extensive hypertrophic scarring of the skin. Such a course is uncommon and has rarely ...
Saigal Saurabh - - 2012
Acute methotrexate toxicity rarely presents as medical emergency in form of multiorgan failure. Acute pneumonitis following low-dose methotrexate is rarely reported in literature. It is important to recognize this, as the drug must be discontinued immediately and rescue measures in form of folinic acid and hydration instituted promptly.
Mounasamy V - - 2012
We report the use of vancomycin laden antibiotic cement beads in a patient with calcaneal osteomyelitis who had prior acute kidney injury (AKI). The patient experienced non-oliguric renal failure after exposure to intravenous vancomycin and recovered well after antibiotic discontinuation and adequate hydration. We are not aware of any similar ...
Turaka Kiran - - 2012
To report laser pointer induced damage to retina and choroid and briefly review literature. A case report of a 13-year old Caucasian boy developed blurry central vision and central scotoma in right eye (OD). He was exposed for one minute to class IIIA green laser pointer of 650 nm wavelength and ...
Janssens K - - 2012
To report a case of anterior segment ischemia (ASI) with rubeosis iridis after circular buckling surgery in a highly-myopic patient which was successfully treated with a second intravitreal bevacizumab injection. Case report and review of the literature. ASI is a rare but potentially serious complication of posterior segment surgery. Finally ...
van Geel N - - 2011
Segmental vitiligo and generalized vitiligo are in general considered to be separate entities. The etiopathogenesis of segmental vitiligo remains unclear, although several hypotheses have been put forward including mainly neuronal mechanisms. The typical association with other auto-immune diseases as seen in generalized vitiligo, seems to be significantly less in segmental ...
Hsu Chia-Yu - - 2011
Subacute inflammatory demyelinating polyneuropathy (SIDP) is an acquired immune-mediated peripheral polyneuropathy with clinical course between 4 weeks and 8 weeks. Rare childhood cases with SIDP had been described in the current literature. We report the first case of childhood SIDP in Taiwan with thorough clinical studies. All of the clinical ...
Williams S Elizabeth - - 2011
BACKGROUND: In 2004 the Clinical Consult Case Review (CCCR) working group was formed within the CDC-funded Clinical Immunization Safety Assessment (CISA) Network to review individual cases of adverse events following immunizations (AEFI). METHODS: Cases were referred by practitioners, health departments, or CDC employees. Vaccine Adverse Event Reporting System (VAERS) searches ...
Stuart Angus - - 2011
The review briefly describes the evolution of hypotheses about cronic thyroiditis, the escape of colloid hypothesis, basement membrane destruction, the auto-immune theory and the role of disregulatory genes.
Butner Stephanie C - - 2011
The purpose of this integrated review of the literature was to summarize the evidence surrounding the effectiveness of rapid response teams. Studies included in this review were written within the last 10 years, in English, and examined the effectiveness of having a rapid response team. Pediatric studies were excluded from ...
Teran Carlos G CG Woodhull Medical and Mental Health Center, Brooklyn; ; New York University, School of Medicine, New York, - - 2011
Silver nitrate is commonly recognized for the toxic effects followed by the direct contact with the skin and mucosa known as argyria, but there is surprisingly little information about the adverse effects of silver nitrate after ingestion. Since only a few cases were reported in the literature, the aim of ...
Hannoun Antoine - - 2011
A case of ectopia cordis (EC) with gastroschisis in a 27-year-old primigravida was diagnosed at 10(3/7) weeks of gestation. The pregnancy was terminated by suction dilatation and curettage. With the increasing use of first trimester ultrasonography, early detection of fetal abnormalities is becoming more frequent. We review other published cases ...
Tadesse W - - 2011
Summary We reviewed the role of peripartum hysterectomy (PH) in the first decade of the 21st century. The study was confined to women who delivered a baby weighing 500 g or more between 2000 and 2009, and who required a hysterectomy within 72 h of delivery for obstetric reasons. Individual case records ...
Amorim-Costa Célia - - 2011
Abstract Objective. To conduct an audit of the Omniview-SisPorto® central monitoring station (CMS) and determine the effect of the measures undertaken to correct identified problems. Methods. All cardiotocograms (CTGs) recorded in randomly selected days of 2006 and 2009, both in the outpatient clinic and labor ward, were reviewed to assess the following ...
Mailath-Pokorny M - - 2011
Proximal femoral focal deficiency (PFFD) represents a rare and complex deformity manifested by hyoplasia of variable portion of the femur with shortening of the entire limb. The condition may be unilateral or bilateral and is often associated with other congenital anomalies. The recent technological advances in ultrasound imaging offer the ...
Fong K W - - 2011
OBJECTIVES: To evaluate (1) diagnostic performance of intracranial translucency (IT) for detection of open spina bifida (SB) and (2) interobserver agreement for visualization of IT during the 11-13 week scan. METHODS: This is a retrospective study in a tertiary referral centre. Two hundred 11-13 week nuchal translucency scans performed by ...
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