A case of homozygous sickle cell anaemia male patient, aged 16 years is reported. The initial symptom following a sickle cell crisis was impairment of vision, progressing rapidly to complete blindness within three days. Within 4 days of admission in the hospital, he lapsed into coma and died four weeks ...

Xanthogranulomatous endometritis is a rare pathologic finding with only five cases reported in the literature. On review of our files over the past 12 years, we found six cases of xanthogranulomatous endometritis, all associated with endometrial adenocarcinoma that had been irradiated by external beam and/or intracavitary implants prior to surgery. ...

Granular cell tumour is a rare neoplasm consisting of nests or ribbons of polyhedral cells with granular eosinophilic cytoplasm and small, dense nuclei. It may occur at various sites throughout the body. Two cases, one of the tongue and one of the rectum, are reported and the pathology and management ...

Curschmann's spirals were found in smears and cell block preparations of five spontaneously occurring pleural and peritoneal fluids. The spirals were similar to those seen in the respiratory tract, although generally much smaller. In three of the five cases, the fluids also contained mucus-secreting adenocarcinoma cells; it is postulated that ...

A case of invasive adenocarcinoma of the uterine cervix with small intestinal differentiation to include numerous Paneth cells is presented. The light microscopic findings are confirmed by immunohistochemical and electron microscopic study. To our knowledge, this is only the second reported case of small intestinal cervical adenocarcinoma that contained Paneth ...

We report the case of a 23-year-old man with a giant-cell tumor of the sphenoid bone. The radiologic manifestations consisted of an expansile mass arising from the sphenoid bone with extension into the cranial cavity and the nasopharynx. The findings with computed tomography and magnetic resonance imaging best reflected respectively ...

Staining with peanut agglutinin (PNA) and with polyclonal antibody to S100 protein have both been recommended as aids in the diagnosis of histiocytosis X (Langerhans' cell histiocytosis). Although a large body of literature attests to the utility of S100 staining in this condition, the few published studies that involve PNA ...

Between 1979 and 1987 12 patients with chondroblastoma underwent fine needle aspiration (FNA). There were eight female and four male patients (age range, 11-35 years) with lesions of the proximal humerus (three cases), distal femur (two cases), proximal tibia (two cases), proximal femur, distal tibia, talus, navicular bone, and fifth ...

Past attempts to subclassify small-cell lung cancer (SCCL) histology (oat cell, fusiform, polygonal, intermediate, etc) have not been useful because of interrater variability and a lack of clinical significance. A review of outcome in a previous series suggested that a different histologic subtype, small-cell/large-cell (SC/LC) conferred an inferior response and ...

A rare case in which cartilage cells were observed in cerebrospinal fluid is reported and the literature reviewed. This phenomenon, occurring in 0.2% of the cerebrospinal fluid specimens, is thought to be caused by accidental puncture of the intervertebral disk. It has the potential of being mistaken for a malignant ...

This paper contains a review of the signs and symptoms of giant cell arteritis, especially speech and respiratory manifestations of the disease, which are demonstrated by a new case history. An elderly woman presented with speech that was falsetto, breathy, and marked by downward pitch breaks and phonation breaks. In ...

A case of adenocarcinoma arising in Meckel's diverticulum in a 55 year old man is reported, and a brief review of the literature is presented. The patient developed low abdominal pain and showed elevation of serum carcinoembryonic antigen (CEA) level. The tumour was located in the apical portion of the ...

We have reported a case of pseudomyxoma peritonei manifested as a splenic mass in a 38-year-old woman. Upon reviewing previously reported cases of pseudomyxoma peritonei with visceral involvement or extension above the diaphragm, we conclude that such spread of the disease does not significantly alter the prognosis. Furthermore, our findings ...

Adenocarcinoma of the esophagus has been considered an uncommon tumor, accounting for fewer than 8% of all cases of esophageal cancer. To determine the current frequency of adenocarcinoma of the esophagus, we reviewed data from the tumor registries of the Commonwealth of Massachusetts, the University Hospital (UH), and the Boston ...

A case of pigmented odontoameloblastoma occurring in the maxilla of an 11-year-old Japanese girl is reported. In addition to the characteristic histopathologic features of odontoameloblastoma, dendritic cells containing melanin pigment were widely distributed in the epithelial element of the ameloblastoma. Fine granules and coarse aggregates of melanin pigment were also ...

Parathyroid adenocarcinoma is a very rare carcinoma with an equal male-female incidence. The clinical picture that adenocarcinoma of the parathyroid presents is the same as that of hyperparathyroidism due to adenoma. Onset of parathyroid adenocarcinoma occurs primarily in the fourth decade of life. It is not incompatible with long-term survival ...

We studied the morphologic, antigenic, and enzymatic characteristics of the histiocytes in an isolated extranodal case of sinus histiocytosis with massive lymphadenopathy (SHML) involving the CNS. To our knowledge, this represents the first immunohistochemically documented case of CNS SHML. The histiocytes exhibited the S-100(+), CD11c(+), alpha-1-antichymotrypsin(+) immunophenotype, which suggests that ...

Two cases of mesonephric duct hyperplasia of the uterus, together with three cases of uterine mesonephric duct remnant, are reported. The latter cases were identified by serial transverse sectioning of 42 surgically resected uteri, yielding a frequency of approximately 7%. Histochemical studies showed no mucin in the cytoplasm of cells ...

Patients in sickle cell crisis may complain of unilateral or bilateral hearing loss which is typically a mild to moderate high-frequency sensorineural hearing loss in the affected ear(s). Auditory acuity can return to precrisis levels. A literature review suggests that the etiology is cochlear ischemia. A review of the literature, ...

Hodgkin's disease (HD) is sometimes difficult to distinguish from non-Hodgkin's lymphomas, and a reliable marker for Reed-Sternberg and related (R-S) cells in paraffin sections would be useful. Ninety-one cases of HD with PNA, anti-Leu M1, and LN-2, and 90 cases with Ber-H2 were studied. The staining results were evaluated independently. ...

An exceptional case of intracranial plasma cell granuloma, located in the right frontoparietal convexity in a 16-year-old boy is reported. Reports of these rare inflammatory lesions locate them primarily in the lungs and in other regions of the body, and only exceptionally in the nervous system; indeed, only three intracranial ...

Proliferative cell indices (PCI) in 20 cases of endometrial adenocarcinoma were obtained by staining DNA polymerase alpha. The PCI ranged from 11.1 to 42.1, averaging 24.7 +/- 8.7. Four cases of stage III all exhibited fairly large PCI (30.4-32.9). In contrast, in 16 cases of stage I the values were ...

Two cases of giant cell fibroblastoma in children are described and the available literature on these uncommon neoplasms is summarized. Several local recurrences were noticed in both of our cases, but no metastases occurred. The histologic appearance was distinctive, but no firm conclusions regarding histogenesis could be drawn. Immunostaining methods ...

A case of gangliocytic paraganglioma (GP) of the ampulla of Vater is reported and the literature reviewed, with special attention to immunohistochemical studies. The present case, which occurred in a 56-year-old woman, shows the typical histological admixture of epithelioid, ganglion and spindle cells. Immunohistochemistry reveals strong reactivity for synaptophysin, Leu-7, ...

Although many cases of Diethylstilbestrol (DES)-associated clear cell adenocarcinoma (CCA) of the cervix and vagina have occurred, few have arisen in patients whose initial gynecologic evaluation has revealed only nonmalignant DES-related changes. We report a case of a 32-year-old lady who developed a stage II CCA after 8 years of ...

A case of spindle and epithelioid cell nevus of the tongue is presented. It shows unusual and distinctive desmoplasia and cells containing melanosomes identified by histochemical and electron microscopic techniques. We believe this is the second case, but the first fully documented report, of this unusual nevus of tongue reported ...

A giant congenital nevocytic nevus (CNN) on the trunk was followed in a patient from age three months to 23-years-old. During that time the nevus underwent pigmentary regression leaving 2-3 mm lentigines without any evidence of vitiligo or halo formation around the giant CNN. Histopathologically, nevus cells remained in the ...

Adenoid-like formations resembling ducts and glands or forming a cribriform pattern have previously been described in malignant gliomas, resulting in some cases in a confusion with metastatic adenocarcinoma. The interpretation of these structures as being composed of anaplastic glial cells rests partly on the presence of transitions to more differentiated ...

Splenomegaly is a frequent clinical finding in multicentric angiofollicular lymph node hyperplasia (MAFH). However, pathologic descriptions of the spleen in MAFH have been reported in only a few cases. The author studied the spleens of seven patients with MAFH (two hyaline-vascular type and five plasma cell type) and reviewed the ...

A case of squamous cell papilloma of the esophagus in a 70-yr-old white woman is reported. The literature is reviewed, summarized, and tabulated. This study found that the average age of a person with a squamous cell papilloma of the esophagus was 51.5 yr, with an associated male:female ratio of ...

Adenocarcinoma arising in the cervix are not common tumors and those arising from mesonephric remnants are extraordinarily rare. A case of mesonephric adenocarcinoma of cervix has been reported in a girl age 1.5 years. This tumor could be diagnosed on the basis of histological examination by criteria laid down by ...

A case of primary hyperparathyroidism is reported in which the initial presentation was an intraoral lesion clinically resembling a peripheral giant cell granuloma. A brief review of hyperparathyroidism is included. Of interest is the fact that most cases of hyperparathyroidism today are found in asymptomatic patients in whom the disease ...

The larynx is rarely the site of an adenocarcinoma. About 60 patients were described in the literature, and the epiglottis was primarily involved in only three. We studied a fourth case in a 77-year-old man. Adenocarcinoma of the larynx is a highly lethal neoplasm that tends to spread to both ...

While clinically suspected in some cases, pulmonary lesions in giant cell arteritis have rarely been described pathologically. We report the findings at autopsy in an elderly woman with typical giant cell arteritis. In addition to inflammation of temporal and other major systemic vessels, large- and medium-sized pulmonary arteries showed focal ...

A search for microcalculi was made in 14 cases of chronic submandibular sialadenitis. Microcalculi were found in all cases. They were within serous acinar cells and ductal cells, within lumina, and interstitially. They were stained variably by periodic-acid/Schiff and Alcian Blue at pH 2.5. Ultrastructural analytical examination showed them to ...

Hairy cell leukaemia affecting primarily the spleen is a very rare feature of this disease at presentation. Splenectomy in such cases would seem to provide a cure. We report a case of primary splenic hairy cell leukaemia in which clinical and haematological remission were achieved after splenectomy, and we review ...

The clinicopathological findings in a new case of a surgically removed, symptomatic xanthogranuloma of the third ventricle are reported. Ultrastructural study showed that the lining epithelium of the tumor was composed of typical leptomeningeal cells, and that transitional forms from leptomeningeal cells into xanthomatous cells were present in the underlying ...

A case of proliferative myositis of the buccinator muscle is reported. To our knowledge, the present case is the second reported in the oromaxillary region. From immunohistochemical and electron microscopic studies, it seems likely that the ganglion-like cells are derived from myofibroblasts or macrophages rather than from striated muscle cells.

Primary adenocarcinoma of the oral cavity is an infrequently encountered problem. Adenocarcinomas are distinctive lesions which can be subclassified according to their tissue growth patterns or histomorphology. The polymorphous low-grade adenocarcinoma of the oral cavity is usually of minor salivary gland origin. We present an unusual case of polymorphous low-grade ...

We report the case of a 33-year-old man with thoracic lymphangiomatosis. The patient had experienced a 17-year history of recurrent chylothoraces and worsening cor pulmonale. The neoplasm was composed of histologically benign lymphatic channels lined by endothelial cells containing factor VIII-related antigen by immunohistochemical staining. The neoplasm filled the chest ...

Presented is a case of giant cell tumor of the distal radius treated successfully by en bloc resection and translocation of the ipsilateral distal ulna. A good functional result was achieved with near full range of pronation and supination and 5 degrees of flexion at the wrist. The advantage of ...

A case of plasma cell granuloma of the tongue in an otherwise symptomless 48-year-old caucasian female is reported. The polyclonal nature of the plasmocytes was revealed by immunostaining of kappa and lambda light chains. Electron microscopic observations showed typical mature plasmocytes. A parasitic etiology of this type of lesion is ...

Three new cases of benign lipomatous lesions of the uterus are described, with particular attention to the possible relation between symptomatology and the presence of mast cells in the neoformation. The literature is reviewed, a brief history is presented of important stages in the study of these forms, and a ...

Granular cell myoblastoma (MGC) is an uncommon benign tumor of mesodermal origin of which no more than sixty cases with genital involvement have been reported. Among the genital organs, the labium majus of the vulva are the predilect site. We hereby contribute three new cases with a genital location (two ...

We describe two cases of sickle cell anemia who were admitted in the hospital with the complaint of backache. X-ray examination and bone scan revealed pathological fracture of vertebral column. These cases are of interest since sickle cell anemia in the Eastern part of Saudi Arabia is reported to run ...

Primary adenocarcinoma of the vermiform appendix is a rare clinical entity that is virtually never diagnosed preoperatively. A case of mucin-producing adenocarcinoma of the appendix manifesting as a pelvic mass is presented. The ultrasonographic finding of a multilocular cystic lesion with thick septa and solid components was consistent with an ...

Nine cases of T-cell lymphoma presenting in the Guizhou province of China between 1982 and 1984 are reviewed. Seven of the patients were male; seven patients have died, the mean survival period being 22 months. The clinical features resembled those reported in Japanese cases, but skin lesions were absent. Histologically ...

Two young adults presenting with acute lymphoblastic leukaemia (ALL) associated with hypercalcaemia and osteolytic lesions were both found to have T cell ALL. Hypercalcaemia is a rare feature of ALL and has not previously been related to T cell disease. Both cases, in some respects, resembled (age between 10 and ...

Twenty-three cases of cervical intraepithelial glandular neoplasia (CIGN)--a term encompassing adenocarcinoma in situ and glandular dysplasia of the uterine cervix--were studied histologically, histochemically for mucins (neutral mucins, sialomucins and sulfomucins), and immunohistochemically for the affinity of four lectins (WGA, PNA, RCA, UEA). For comparison, six cases of cervical invasive adenocarcinoma ...

Nine cases of plasma cell tumors were diagnosed by fine-needle aspiration cytology, the sites of aspiration being soft-tissue swellings in five cases, lymph nodes in three cases, and both soft-tissue swelling and lymph node in one case. The age of the patients ranged from 33 to 74 yrs, with a ...