Ascites is an unusual feature of multiple myeloma. We report a case of ascites occurring early in the course of a patient with myeloma in whom there was no evidence of intra-abdominal plasmacytoma, and the skeleton was relatively spared. The serum contained predominantly polymeric IgA, a feature not investigated in ...

The nosological position of actinic granuloma of O'Brien remains controversial. In this report a typical case is described and the features which distinguish the condition from other closely related granulomatous disorders are discussed. Histological changes are of some value in distinguishing actinic granuloma from atypical facial necrobiosis, granuloma multiforme and ...

We report a case of a 16 year old boy with a chronic progressive form of Multiple Sclerosis treated with lymphocytapheresis and a low dose regimen of cyclophosphamide. A progressive improvement in the disability index and slowing of the clinical course were obtained. No side effects were observed. Depletion of ...

The occurrence of seven cases of multiple myeloma over seven years in a small community 15 miles from a plant reprocessing nuclear fuel caused much local concern. A case control study of 34 confirmed cases in the health district during 1974 to 1980 revealed no excess of known risk factors ...

There may be an increasing incidence of multiple sclerosis in South Africa. All newly-diagnosed white Afrikaans-speaking patients from the Pretoria area were examined over a 12-month period and 5 new cases were diagnosed. This is a highly significant rise over the expected 0,2/100 000/year (P less than 0,001).

A patient with typical clinical and electromyographic features of amyotrophic lateral sclerosis (ALS) was found to have abnormal somatosensory evoked potentials (SEPs). Evoked responses are generally considered to be normal in ALS despite occasional pathological and clinical evidence of sensory involvement. Thus, abnormal SEPs are considered to argue against a ...

We present a case of an 8-year-old girl, who has, since birth, developed multiple angiomatous lesions of the skin. The evolution has been progressive and eruptive, with the lesions, beginning as reddish papulae, acquiring later a verrucous appearance. The case has revealed no associated systemic symptoms nor relevant family history ...

Pyogenic granulomas are vasoproliferative, inflammatory lesions composed of granulation tissue, which occur on cutaneous or mucosal tissues, often arising secondary to other processes such as trauma or infection. Conjunctival pyogenic granulomas are not rare, but corneal involvement is very unusual and can occasionally lead to problems in the differential diagnosis ...

Four cases of polycythemia associated with myeloma are described. Three of four had polycythemia vera with IgA monoclonal gammopathy. The possible relationship between chronic myeloproliferative disorder and myeloma is discussed. Review of the literature revealed 11 such cases, four of which had a history of 32P therapy for polycythemia vera.

A case of kappa light-chain myeloma with pleural involvement is reported. The diagnosis was made by pleural biopsy, pleural fluid cytology, and urine immunoelectrophoresis. A review of the literature on pleural involvement in multiple myeloma revealed that this is the first reported case in patients with light-chain myeloma.

Ultrastructural findings in 2 cases of actinic granuloma are presented. The changes observed at the periphery of the lesion and in the elastic fibers, with early stage of damage, were similar to those described in actinic elastosis. Later, an histiocytic reaction which was apparently directed against damaged elastic fibers was ...

This article reviews the four major categories of explanations into the etiology of multiple personality disorder including supernatural, physiologic, psychologic, and sociologic. From these categories and their subdivisions, a series of hypotheses was developed. A paradigmatic description of a typical case of multiple personality was then created from a synthesis ...

Oral symptoms and signs of multiple myeloma are common. An unusual case with pathologic fracture of the pterygoid process and external root resorption is presented. The literature is reviewed with respect to the prevalence of maxillofacial manifestations of multiple myeloma and the presence of such manifestations as the first sign ...

A multiple-hole needle for biopsy was designed. Use of needle diagnoses were obtained for 420 cases. Some of these were not diagnosed previously with other biopsy methods. This report describes biopsy procedure with case presentation, showing the advantage of this technique. The overall rate of successful diagnosis by biopsy method ...

A case of IgA multiple myeloma presenting with a left pleural effusion due to direct involvement of the pleura is reported. The diagnosis was suspected on the plain chest film showing the osteolytic lateral end of the left clavicle. Pleural fluid cytology and pleural biopsy confirmed the pleural involvement. Such ...

This paper reports on a 54-year-old male in whom multiple sclerosis developed 10 years prior to his death from glioblastoma confirmed at autopsy. A causal relationship is still uncertain despite the 24 cases of concurrent multiple sclerosis and glioma reported since 1938. We discuss the neuropathologic and epidemiologic evidence for ...

A patient presented with plasma cell leukaemia and was found to have an IgE secreting multiple myeloma. IgE myeloma is very rare with only 18 cases recorded. However, this case is the fifth recorded of IgE myeloma associated with plasma cell leukaemia. Since plasma cell leukaemia only occurs in 1.6% ...

A case of amyloidosis of the colon associated with multiple myeloma is presented. The unusual situation was that of obstructive signs with radiologic features of "megacolon and volvulus." A high index of suspicion and meticulous histologic search will demonstrate involvement of the gastrointestinal tract in 98 per cent of patients ...

Primary endometrial and endocervical granuloma inguinale (donovanosis) was diagnosed in an 18-year-old Melanesian woman in Papua New Guinea. Granulomatous involvement of the parametrium, salpinges, ovaries, and ureters was associated with ureteric obstruction and bilateral hydronephrosis. Granuloma inguinale of the cervix, labia majora, and anus developed after diagnostic endometrial curettage. Treatment ...

Twelve cases are reported in which multiple sclerosis was discovered unexpectedly at necropsy. Four of the patients had no known previous history of neurological illness, four did have a previous neurological or neuropsychiatric disturbance, but multiple sclerosis was never entertained in the differential diagnosis and four had a history of ...

A case of tuberous sclerosis diagnosed at autopsy in a neonate at 28 weeks gestation is described. This is believed to be the earliest case yet reported. The CNS lesions consist of cortical tuberosities, heterotopic white matter nodules and subependymal nodules. These nodules consist predominantly of giant astrocytes but a ...

Necrobiotic xanthogranuloma with paraproteinemia is characterized by multiple nodules or plaques that involve the periorbital area along with other parts of the body. A dysproteinemia due to an IgG paraprotein is associated with the condition; low serum complement, cryoglobulinemia, leukopenia, and hyperlipemia are also sometimes seen. Multiple myeloma is present ...

This article describes a case of osteopathia striata with cranial sclerosis. The patient also has multiple sclerosis. The symptomatology includes a right sided conduction deafness and a left maxillar nerve deficit, which were both attributed to the bone disorder. The authors review the literature of this rare genetic syndrome and ...

Report of 2 patients suffering from sensory peripheral neuropathy and multiple myeloma. In 1 case, peripheral neuropathy occurred several months before the appearance of multiple myeloma. A peripheral nerve biopsy exhibited numerous amyloid deposits within the endoneurium. Amyloid deposits have been estimated to occur in 15% of cases of multiple ...

Multiple meningiomas are a seldom encountered neoplasm. Most authors report an incidence ranging from 1 to 3% of all meningiomas. The routine use of CT has resolved diagnostic problems involved with multiple meningiomas; nevertheless, they still present several nosologic problems. In fact, it may be difficult to differentiate "true multiple ...

Documented cases of classic amyotrophic lateral sclerosis (ALS) combined with severe dementia are few and come from the isolated populations of the Western Pacific. In this report, three women had a clinically and neuropathologically documented combination of ALS and dementia. In all cases the symptoms and signs of ALS were ...

The past decade has witnessed a marked increase in the reported incidence of multiple personality patients. This review examines 16 papers published between 1970 and early 1981 that reported 29 cases of multiple personality other than the 50 cases reported earlier by George Greaves. These 29 case reports confirm that ...

Lhermitte's sign was experienced by 33.3% of 114 patients with multiple sclerosis, and in 16% it occurred in the first episode. Eleven patients with subacute combined degeneration of the cord due to pernicious anaemia also were reviewed, and one reported Lhermitte's sign. Review of the literature suggests that the symptom ...

This brief case report illustrates the utility of angioplasty in lower-extremity limb salvage situations that often occur following failure of femoropopliteal bypass grafting, as well as the use of angioplasty in tibial vessels. It also demonstrates that angioplasty of multiple lesions can be successfully achieved at a single sitting.

The case of a thirty-seven-year-old man with eosinophilic granuloma of the ureter is discussed. Preoperative x-ray studies disclosed distal ureteric regional stenosis and moderate hydronephrosis with small stone shadows. A segmental ureterectomy and vesicoureteral neostomy were performed. Pathologic examination of the removed specimen revealed markedly infiltrated eosinophils of the ureteric ...

Among the indigenous people of tropical and subtropical countries neuromyelitis optica is more common than multiple sclerosis (MS), which is exceptionally rare. Alternatively, one might conclude that when MS does occur in these countries it usually assumes the spinal-optic form. The evidence on which these statements are based is reviewed, ...

Caudal vs rostral transmission time has been studied in patients with multiple sclerosis (MS). In the majority of the cases, prolongation in latency was more severe in the caudal segment, which suggests that this part of the brainstem is more commonly affected in MS. The difference between pontomedullary and pontomesencephalic ...

The concurrence of multiple sclerosis and primary intracranial neoplasms is uncommon. The literature contains 20 cases of multiple sclerosis associated with gliomas and nine cases with non-gliomatous neoplasms. This report describes a protoplasmic astrocytoma and arteriovenous malformation found incidentally at autopsy of a 63-year-old woman with a 25-year history of ...

The purpose of this study is to report the results of megavoltage irradiation in 23 previously unreported cases of extramedullary plasmacytoma of the head and neck. It has been found that 3500 cGy (rad) in three weeks provides good local control of disease with minimal morbidity and a significant proportion ...

A case of tuberous sclerosis in a preterm newborn baby is described, in whom there were also multiple rhabdomyomas of heart, diaphragmatic hernia, giant-cell astrocytoma of lateral ventricle and malrotation of the intestine. This is the first report of an association of tuberous sclerosis with diaphragmatic hernia. The presence of ...

The occurrence of tuberous sclerosis among Indians has not been reported earlier. In the Ernakulam District, Kerala, in a kindred of 27, seven cases with oro-facial or facial lesions of tuberous sclerosis were observed. None of the individuals was mentally retarded, nor was there any history of systemic anomalies. The ...

Seven cases are reported from Australia of benign granulomas of the conjunctiva occurring principally in children. Conjunctival granulomas of this kind have not previously been recorded in Australia. Both clinically and histologically they are identical to those described by Ashton and Cook as allergic granulomas of the conjunctiva exhibiting the ...

In a case of severe multiple sclerosis primarily affecting the spinal cord, dorsal column stimulation over a 2-year period was followed by some functional improvement in locomotion. Additionally, the H reflex recovery cycle, which was quite abnormal before stimulation, showed a pronounced shift toward a more normal pattern with dorsal ...

Bilateral involvement of the temporal bones is a rare manifestation of eosinophilic granuloma, a disease characterized by solitary or multiple foci of osteolytic damage. We report two cases in which the ambiguous and unusual initial symptoms and clinical course constituted a difficult diagnostic problem. In each case, the therapeutic approach ...

Seventeen cases of clinically and histologically characteristic chondrodermatitis nodularis chronica helicis (CNCH) are presented. Thirteen histologic specimens revealed transepidermal elimination (TE) of necrobiotic material from the dermis. This elimination occurred through transepidermal channels, slits, or erosions overlying a dermal necrobiotic granuloma. The granuloma was surrounded by granulation tissue composed of ...

The clinical and pathologic features of 86 roentgenographically solitary pulmonary granulomas were reviewed to determine etiology and to provide guidelines for histologic evaluation. Fungal or acid-fast organisms were identified within the tissue in 60 cases (70%) and fragments of a helminth were found in one. The organisms were almost always ...

We report on the rare combination of multiple sclerosis (MS) and cerebral glioblastoma in a 50-year-old deceased male. MS was not diagnosed clinically. The particularities of the case in comparison with the known data from the literature are the partly more active MS plaques and extensive necroses of the glioblastoma, ...

An instance of multiple myeloma (MM) in a married couple is discussed, since cases of MM in husband and wife have rarely been observed. The patients were aged 60 when the disease was discovered, and the interval between the diagnosis in the mates was 44 months. Genetic or environmental factors ...

Only 30 cases of multiple ureteral diverticula have been reported previously. We present a new case of this benign condition and review concepts concerning its etiology. Usually discovered on retrograde pyelography, multiple ureteral diverticula are only inconsistently associated with a history of obstruction or infection. When present, however, these factors ...

The authors report two cases of ceroid-containing granulomas of the gallbladder, an entity not previously reported in the American medical literature. They postulate that in some cases of chronic cholecystitis, bile provides the substrate for the formation of ceroid within histiocytes. The ceroid granulomas were incidental findings associated with chronic ...

Eighteen cases of granuloma annulare were classified histopathologically and examined by direct immunofluorescence. The three different histopathologic types of granuloma annulare were compared with the result of immunofluorescence examination. No features of leukocytoclastic vasculitis were seen. Direct immunofluorescence of granuloma annulare does not reveal any consistent diagnostic pattern. Dermal desposition ...

A new case of IgE myeloma (Des), a woman aged 55, is presented. The monoclonal Ig was identified as an IgE of the kappa type. The case history is detailed. Bone lesions were absent; there were up to 12% plasma cells in the peripheral blood; therapy with cytostatic drugs could ...

A case of Paracoccidioidal granuloma in Northern Nigeria is presented. The fungus could be cultured and identified as Paracoccidioides brasiliensis. Histology revealed a fungal lesion due to a yeast like organism. The patient responded to long acting Sulphormethoxine (Fanasil). A variation from the classic histopathological description and association of pustular ...

We present two cases of myelomatous involvement of the skull. Correlative studies with routine radiography, angiography, and encephaloscintigraphy were performed. The areas of involvement of the skull were confirmed as autopsy. A mixed pattern of photon-deficient and photon-abundant lesions was noted. The clinician should be aware of such mixed patterns.

Two cases of multiple gastric polyps are described. In both cases a large number of hyperplastic polyps were found in the antrum and body of the stomach. A total gastrectomy was performed in these two patients. Histologically the polyps were benign; in one case gastritis with metaplasia was present. The ...