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Fiume Monice M MM Cosmetic Ingredient Review Senior Scientific Analyst/Writer, Washington, DC, - - 2014
The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of 24 Vitis vinifera (grape)-derived ingredients and found them safe in the present practices of use and concentration in cosmetics. These ingredients function in cosmetics mostly as skin-conditioning agents, but some function as antioxidants, flavoring agents, and/or colorants. The Panel ...
Ames Paul R J PR Haemostasis & Thrombosis Department, William Harvey Research Institute, Charterhouse Square, London, United Kingdom Haemostasis & Thrombosis Department, St George's Hospital, London, United Kingdom - - 2014
To review the diagnostic difficulties of a prolonged activated partial thromboplastin time (aPTT) when 2 inhibitors with opposite clinical presentations coexist, we searched MEDLINE from January 1970 to November 2013 using acquired, factor VIII (FVIII), factor IX, hemophilia A and B, inhibitor, lupus anticoagulant (LA), antiphospholipid, anticardiolipin, anti-β2-glycoprotein I, antibodies, ...
Shen Xian X Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, Baltimore (Mss Shen and Kiptanui, Drs Dutcher, Palmer, Liu, Al-Jawadi, and Zuckerman, and Mr Khokhar); Department of Surgery, University of Maryland, Baltimore (Mr Zhu); and IMPAQ International, Columbia, MD (Dr - - 2014
To synthesize the existing literature on benefits and risks of anticoagulant use after traumatic brain injury (TBI). Systematic review. A literature search was performed in MEDLINE, International Pharmaceutical Abstracts, Health Star, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) on October 11, 2012, and updated on September 2, ...
Loomba Rohit S RS Department of Pediatric Cardiology,Children's Hospital of Wisconsin/Medical College of Wisconsin,Milwaukee,Wisconsin,United States of - - 2014
Agenesis of the venous duct is a rare congenital anomaly resulting in abnormal drainage of the umbilical vein into the foetal venous circulation. The clinical presentation and prognosis is variable, and may depend on the specific drainage pathways of the umbilical vein. We present two foetuses with agenesis of the ...
Cook Rhett M RM University of Utah Health Sciences Center, Salt Lake City, UT, - - 2014
To report a case where rivaroxaban was used in the management of an ovarian vein thrombosis and to briefly review the literature, pathophysiology, and clinical implications therein. A 30-year-old previously healthy woman was diagnosed with acute, spontaneous, left-ovarian vein thrombosis (OVT) with proximal extension into the renal vein. After initial ...
Sakuraba Motoki M Department of Thoracic Surgery, Sapporo City General Hospital, Sapporo City, Japan. Electronic address: - - 2014
Spontaneous thymic hemorrhage in a normal thymus in neonates and infants has been reported in the literature. Only one case of spontaneous thymic hemorrhage in an adult has been reported to our knowledge. We herein report the case of an adult who had a cardiac operation 26 years previously and who was ...
Gordon Oren O Department of Pediatric, Hadassah Hebrew-University Hospital, Ein-Kerem Campus, Jerusalem 91120, Israel. Electronic address: - - 2014
Neonatal antiphospholipid syndrome (APS) is rare and only few cases have been reported, most of them describing trans-placental passage of penetrable maternal antibodies. The current article aims at defining the clinical and biochemical features of the de novo occurrence of neonatal APS and considerations for long-term treatment. We present a ...
Bushnell Cheryl - - 2014
Thrombosis of the dural sinus and/or cerebral veins (CVT) is a rare but potentially devastating type of stroke that tends to occur in young adults, especially women. In this article, the abbreviation CVT refers to either cerebral venous thrombosis or dural sinus thrombosis. The purpose of this review is to ...
Sahin Neslin N Sifa University School of Medicine, Izmir; Department of Radiology. Electronic address: - - 2014
We report a 48-year-old woman presenting with subarachnoid hemorrhage (SAH) as the first manifestation of superior sagittal sinus thrombosis. In a literature review of 73 cases, SAH associated with cerebral venous thrombosis (CVT) was usually seen at the cerebral convexities. SAH was adjacent to thrombosed venous structures; therefore, the most ...
Rath Claus - - 2014
Pacemaker lead malpositioning may lead to severe clinical adverse events. Rarely, cases of inadvertent placement of a lead into the left ventricle are reported in the literature. We herein report a case of pacemaker lead malpositioning into the left ventricle via a persistent foramen ovale in a male caucasian patient. ...
Brown Anthony A Department of Radiology, University of Colorado hospital, Denver, - - 2014
Pseudocysts containing activated enzymes are a common complication of pancreatitis. Pseudocysts can rupture into adjacent structures including the peritoneal cavity, adjacent organs, and rarely vascular structures. While arterial pseudoaneurysms and venous thrombosis or occlusion are well known complications of acute and chronic pancreatitis, only 17 cases of pancreas-portal venous fistula ...
Chang Grace G Harbor-UCLA Medical Center, Torrance, California, - - 2014
Phlegmasia cerulea dolens (PCD) is an aggressive and life-threatening form of venous thrombosis complicated by ischemic necrosis. Massive thrombosis extends to collateral veins resulting in venous congestion with fluid sequestration in the interstitium causing collapse of arterioles, which progresses to ischemia and, if severe, circulatory collapse and shock. The mortality ...
Corriveau Sophie S Department of Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address: - - 2014
We describe the case of a 29-year-old woman with peripartum cardiomyopathy (PPCM) complicated by multiple cerebral infarcts. Current treatment of PPCM is reviewed with a focus on the role of anticoagulation in PPCM.
Beqqal K K MD, Dermatologist, APHP, Department of Dermatology, Hospital Cochin, Paris Descartes University, Paris, France, Department of Dermatology, Ibn Sina Hospital, University of Mohammed V-Souissi, Rabat, - - 2014
In the setting of protein C deficiency, skin necrosis, which occurs most often at the initial phase of oral anticoagulants therapy, is a rare side effect. Six cases have previously been reported in the literature. In this case report, we present a protein C deficient 42-year-old woman who was being ...
Struijk-Mulder M C MC Department of Orthopaedic Surgery and Traumatology, Isala Clinics, Zwolle, the - - 2014
Introduction: There is a paucity of data regarding the risk of deep vein thrombosis during hip plaster cast immobilisation. The purpose of this article was to review the available evidence regarding the incidence of symptomatic venous thromboembolism (VTE) during hip plaster cast immobilisation. Methods and Materials: All papers describing hip ...
Hadjigeorgiou Georgios F GF Department of Neurosurgery, Red Cross Hospital, Athens, - - 2014
Mild traumatic brain injury is common in elderly patients, many of whom are on anticoagulant. The common practice is to discharge these patients from the emergency room if the computed tomography (CT) of the brain is normal. However, a very small proportion of these patients may develop a life threatening ...
Akita Koji K Division of Cardiology, Department of Internal Medicine, National Defense Medical College, - - 2014
We herein describe a case of acute spinal subdural hematoma (SSDH) during the administration of high-dose corticosteroids and intravenous heparin for the treatment of active lupus nephritis. After SSDH was promptly diagnosed using magnetic resonance imaging (MRI), the patient recovered well with conservative treatment involving the discontinuation of heparin sodium. ...
Sasaki Yosuke Y Department of Nephrology, Okinawa Chubu Hospital, Okinawa, - - 2014
Nephrotic syndrome (NS) may be complicated by thromboembolism, which occasionally manifests as stroke. Although the optimal, standardized approach to the prophylaxis and management of thromboembolic complications associated with NS has not been established, anticoagulation with heparin and subsequent warfarin is the de facto standard of treatment. Dabigatran, a novel direct ...
Gruenebaum Dane D DD Department of Internal Medicine, Michigan State University, B-301 Clinical Center, East Lansing, MI 48824, - - 2014
Hemorrhagic side effects are the bane of oral anticoagulation. Despite careful selection of medications and close monitoring, some adverse events are unavoidable. The available literature about the risks of triple oral anticoagulation therapy versus dual antiplatelet therapy does not address all of the medication combinations currently available. This report describes ...
Young Katie K School of Clinical Sciences, University of Bristol, Bristol, - - 2014
We report a previously well 9-year-old boy who presented with an acutely swollen left arm after horse riding. Left subclavian vein thrombosis was demonstrated by MR venography but there was no evidence of an underlying anatomical abnormality. The child was successfully treated with catheter directed thrombolysis and anticoagulation with intravenous ...
Labgaa Ismaïl I Department of Visceral Surgery, CHUV University Hospital, Rue du Bugnon 46, CH-1011, Lausanne, - - 2014
Extrahepatic Portal vein aneurysm (EPVA) is a rare finding that may be associated with different complications, e.g. thrombosis, rupture, portal hypertension and compression of adjacent structures. It is being diagnosed more frequently with the advent of modern cross-sectional imaging. Our review of the English literature disclosed 13 cases of thrombosed ...
Buyuklu Mutlu M http://orcid.org/0000-0002-4513-2483 Department of Cardiology, Erzincan University, Erzincan, - - 2014
Warfarin is commonly used for prevention of embolic events. Bleeding is the main side effect of warfarin. Lingual and sublingual haematoma are rare. In the literature, nine cases have so far been reported. We report the case of a 70-year-old Caucasian woman who developed spontaneous lingual and sublingual haematomas while ...
Protopapa Muaria Nuikoletta MN Department of Internal Medicine, University Hospital of Patras, Rio Patron, 26500 Patras, Greece. - - 2014
Cytomegalovirus-associated thrombosis has been extensively reported in the medical literature, mainly in immune-compromised patients. However, the association with splenic infarcts has been rarely mentioned. We report the case of a 38-year-old Caucasian man of Hellenic origin with acute cytomegalovirus infection presenting with spontaneous splenic infarcts. Echocardiography did not show any ...
Ozaki Yukio Y University of Yamanashi, Yamanashi, - - 2014
The Editors of Thrombosis Journal would like to thank all our reviewers who have contributed to the journal in Volume 11 (2013).
Peixoto Marcus Vinicius da Costa MV Universidade de Fortaleza (Unifor), 60811-905 Fortaleza, CE, - - 2014
Objectives. A review of the literature reports neonatal thrombosis and antiphospholipid antibodies cases through a retrospective study that focuses on the pathogenesis and main clinical and laboratory manifestations of this disease. Methods. The case reports were selected from PubMed. The keywords used to search were neonatal, antiphospholipid syndrome, thrombosis, and ...
Ashrafzadeh Farah F Department of Pediatric Neurology, Mashhad University of Medical Sciences, Mashhad, IR - - 2013
Cerebral sinovenous thrombosis (CSVT) in children has rarely been reported in the literature, especially without underlying disorder. It has increasingly been diagnosed due to clinical awareness and sensitive neuroimaging techniques. The aim of this article was to report a case of cerebral sinovenous thrombosis without underlying disorder. We reported a ...
Nyo Myat Tun Lin - - 2013
Severe thrombocytopenia with bleeding associated with a life-threatening thrombotic manifestation in the setting of antiphospholipid syndrome is a major diagnostic and therapeutic challenge for the clinician. Hemorrhage is a less common complication than thrombosis in patients with APS, although severe thrombocytopenia can sometimes result in bleeding. There are no evidence-based ...
Kitamura Aki - - 2013
Pseudoaneurysm of the hand is rare, with only a few cases reported in the literature, and is usually related to trauma. Early treatment is recommended for pseudoaneurysm after it is diagnosed. We report the surgical treatment of spontaneous pseudoaneurysm of the hand in a patient on anticoagulant therapy.
Wool Geoffrey D GD Laboratory Medicine Service, MC 113A, UCSF & VA Medical Center, 4150 Clement St, San Francisco, CA 94121; - - 2013
To review various anticoagulation therapies and related laboratory monitoring issues, with a focus on factor X-related chromogenic assays. A case-based approach is used to review pertinent published literatures and product inserts of anticoagulation drugs and to look back on clinical use of factor X-related chromogenic assays. The number of anticoagulants ...
Dhillon Priyanka - - 2013
We report the case of splenic infarct secondary to embolisation from a polypoid 17mm×10mm thoracic aorta thrombi in a 60 year-old female. The management and prognostic value of thoracic aorta thrombi are poorly defined in literature. This patient was successfully treated with oral anticoagulation as opposed to surgical intervention. Repeat ...
Lauw Mandy N - - 2013
Cerebral venous thrombosis (CVT) is a rare manifestation of venous thromboembolism (VTE) and stroke. The aim of our systematic review was to provide an updated summary of the strength of association between CVT and thrombophilia and to explore the relevance of thrombophilia for recurrence of CVT or other VTE, or ...
Keefe Kelley - - 2013
The use of thrombolytics delivered through an external ventricular drain has improved outcomes in intraventricular hemorrhage, a disease with a poor prognosis; however, presence of an arteriovenous malformation is generally considered a contraindication to thrombolytic use. Due do the high mortality with the current standard of care, thrombolytics should be ...
Kitamura Yohei - - 2013
Isolated cortical vein thrombosis (ICVT) is extremely rare. Only single case or small series of ICVT have been reported; clinical details are still uncertain. We report a case of isolated superficial sylvian vein thrombosis with exceedingly long cord sign. A 14-year-old female with severe sudden onset headache visited our hospital. ...
Gevaert Andreas - - 2013
Heparin-induced thrombocytopenia is a potentiallylife-threatening complication of heparin or low-molecular-weight heparin administration. We describe the case of a patient with heparin-induced thrombocytopenia complicated by pulmonary embolism, successfully treated with fondaparinux, a factor Xa inhibitor. We also review the literature regarding the use of this anticoagulant in heparin-induced thrombocytopenia complicated by ...
Mandanas Stylianos - - 2013
Acute adrenal insufficiency is a potentially lethal condition rarely caused by bilateral adrenal haemorrhage due to heparin use. Most of the times, it is difficult to establish the diagnosis, as symptoms are not specific. Few cases have been reported in the literature. A 52-year-old Caucasian woman presented with abdominal pain, ...
Li Luan - - 2013
Henoch-Schonlein Purpura (HSP) is one of the most common types of vasculitis in children. The characteristic clinical manifestations include non-thrombocytopenic purpura, arthritis or arthralgia, abdominal pain, gastrointestinal hemorrhage and renal abnormalities. Thrombosis has been reported as, a rare complication of HSP. We present the case of a 14-year-old boy who ...
Robert Thomas - - 2013
Background Developmental venous anomaly (DVA) is considered a benign and asymptomatic cerebrovascular malformation, and only isolated cases of symptomatic DVAs are described in the literature. Even more rarely will these symptoms come from an intraparenchymal hemorrhage caused by the DVA.Methods and Results We present two symptomatic DVAs by intracerebellar hemorrhage. ...
Bedogni Alberto - - 2013
In this report, we describe the first successful case of microvascular free tissue transfer in a patient with Evans Syndrome (ES), a rare form of idiopathic thrombocytopenic purpura (ITP) and associated autoimmune hemolytic anemia (AIHA). Microvascular surgery in the setting of ES is likely to have higher complication rates because ...
Lazo-Langner Alejandro - - 2013
New oral anticoagulants, including dabigatran, rivaroxaban, and apixaban, have been recently approved for primary and secondary prophylaxis of thromboembolic conditions. However, there is no clear strategy for managing and reversing their anticoagulant effects. We aimed to summarize the available evidence for clinical management and reversal of bleeding associated with new ...
Badea Radu - - 2013
We present the case of a patient undergoing long-time treatment with oral anticoagulants for a severe vascular pathology who had a major subcapsular liver bleeding as well as retroperitoneal bleeding. The purpose of the paper is to present the specific characteristics of this case, to review the literature that concentrates ...
Sarma Amy A Department of Medicine, Brigham and Women's Hospital, Boston, MA, - - 2013
Novel oral anticoagulants are increasingly used for stroke prophylaxis in patients with non-valvular atrial fibrillation. While these agents offer a more predictable pharmacokinetic profile, the lack of readily available laboratory tests to monitor the level of anticoagulation and absence of an antidote or established therapies to reverse the anticoagulant effect ...
Hawkins Seth C SC Department of Emergency Medicine, UNC-Chapel Hill School of Medicine, Chapel Hill, NC. Electronic address: - - 2013
An increasing number of patients routinely undergo long-term anticoagulation with warfarin or other pharmacological agents. There is little evidence and no consensus documents in the literature regarding the appropriateness and relative risk of their participation in wilderness activities. We present a case report, conduct an analysis of the limited literature ...
Walner David L - - 2013
Postoperative bleeding is a well-recognized complication after tonsillectomy. We believe significant variation exists in how bleeding following tonsillectomy is reported and that a standardized system is needed. Our goal was to develop such a system. Relevant literature was found on Ovid Medline. Studies published from 1996 to 2009 involving post-tonsillectomy ...
Shaw Nick J - - 2013
The first part of this review focused on the skeletal aspects of vitamin D. This second part reviews some of the available evidence that vitamin D may have a physiological extraskeletal role beyond its traditional effect on the skeleton. This aspect has influenced the definition of vitamin D deficiency and ...
Bracard S - - 2013
The most frequent risk in endovascular aneurysm treatment is thromboembolic complications. Thus adjuvant pharmaceuticals are largely focused on preventing and treating these latter. Additionally symptomatic treatment of subarachnoid hemorrhage (SAH) and treatments to avoid vasospasm will enter into play in cases of ruptured aneurisms. Consensus exists in the literature neither ...
Dangle Pankaj P - - 2013
Rectus sheath hematoma (RSH) is uncommon and is often reported in the setting of anticoagulation or trauma. Typically RSH presents with localized or diffuse abdominal pain and a fixed abdominal wall mass, however, various presentations and complications have been reported depending on the setting and extent of the hematoma. We ...
Dharmasena Aruna - - 2013
To report a case of bilateral spontaneous hyphaema in a patient on warfarin sodium for atrial fibrillation and COPD. A case report and literature review. A 76-year-old man presented with bilateral spontaneous hyphaema. There was no anterior chamber pathology known to predispose for spontaneous bleeding except for a history of ...
Marshall Sarah - - 2013
Dabigatran etexilate is a newly approved agent for prophylaxis of stroke in atrial fibrillation. Through narrative review, the authors assess evidence of the efficacy of dabigatran in stroke prevention, focusing on the multicenter, randomized trial RE-LY. The authors complement this with a review of the clinical efficacy of standard treatments ...
Saettele Megan R - - 2013
Congenital anomalies of the inferior vena cava (IVC) are increasingly recognized with CT and venography techniques. Although many patients with IVC anomalies are asymptomatic, recent studies have suggested an association with venous thromboembolism. We report the case of a 62-year-old woman with extensive venous clot involving the infrarenal segment of ...
Avila M L - - 2013
BACKGROUND: Heparin-induced-thrombocytopenia (HIT) has increasingly been reported in children as an indication for use of new alternative anticoagulant drugs (NAADs). OBJECTIVES: To systematically review the literature regarding: a) the incidence and prevalence of seroconversion and HIT and b) the clinical/laboratory findings and management of HIT in children. DESIGN/METHODS: MEDLINE and ...
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