A rare case of gliosarcoma occurring in the posterior fossa of a 62-year-old man is reported. Histologically, the tumor closely resembled that of a typical case of malignant fibrous histiocytoma (MFH). Such features have not been reported previously in gliosarcoma. The importance of using an immunoperoxidase preparation against the glial ...

Fourteen histologically proved specimens of clear cell sarcomas (CCS) of tendon sheaths were studied for the presence of S-100 protein. Eleven cases were strongly positive, and 2 cases were weakly positive. There was only one case which was absolutely negative for this protein. This technique was useful to diagnose tumours ...

A case of malignant paraganglioma arising from the posterior mediastinum and presenting with a chest wall metastasis is reported with immunocytochemical and ultrastructural documentation. The pathobiologic features of this rare disease are reassessed with a review of the literature. Cytoarchitectural features do not provide reliable information regarding malignant potential. However, ...

A preliminary comparison of the reported incidence of Kaposi's sarcoma among males under 60 years of age residing in San Francisco was conducted using merged San Francisco AIDS Registry and California Tumor Registry (CTR) data. For the years 1980-1986, the number of cases reported by both registries was similar. However, ...

Considering the different localizations of malignant fibrous histiocytomas (MFH), that of the recto-vaginal septum is extremely rare. The present report describes a case, probably the first in literature, characterized by a storiform-pleomorphic histological type, treated with posterior exenteration and adjuvant chemotherapy. The Authors stress the still controversial histogenetic problem, as ...

Well-differentiated papillary mesothelioma (WDPM) is considered to be a distinct subtype of peritoneal mesothelioma. Although the WDPM is usually qualified as benign, the natural history of this lesion has not been clearly established. This report relates to two WDPMs which were found incidentally. In a 51-year-old man the WDPM developed ...

The quality of life is becoming more and more important for women after demolitive surgery for genital malignancies. A sample of 58 cases of genital malignancies are compared with 50 cases of benign neoplasms (fibroids) and their effects on sexuality, as a parameter of the quality of life, are studied ...

We report 3 cases of malignant fibrous histiocytoma occurring as primary neoplasms of the skin. The first case developed in a leg ulcer of traumatic origin. The second developed on the lower lip at the site of a squamous cell carcinoma which had been treated by radiotherapy. The third arose ...

Nine cases of undifferentiated sarcoma of the liver in childhood were investigated by conventional light microscopy, immunohistochemistry, and DNA flow cytometry. Different histologic patterns were discernible. In some cases, areas resembling poorly differentiated rhabdomyosarcoma were present. This histologic diversity was supported by the immunohistologic detection of desmin and cytokeratins in ...

Kaposi's sarcoma in transfusion-associated acquired immunodeficiency syndrome is rare; to our knowledge, only four previous cases have been reported. We report a unique case of transfusion-associated acquired immunodeficiency syndrome in a 74-year-old woman. At autopsy, both lungs were extensively affected by Kaposi's sarcoma, Pneumocystis carinii, and cytomegalovirus infection. These three ...

Seventy-nine cases of Kaposi's sarcoma (KS), which correspond to one of every 1,000 malignant tumors, were reviewed at the National Institute of Cancer (NIC), Bogotá, Colombia, from 1935 to 1985. Seventy-four percent of the patients were older than 65 years of age. The male to female ratio was 8:1. In ...

The important association of neoplasia and rheumatic disease was reviewed. The literature in the last year included case reports of neoplasia, particularly hematologic, causing arthritis by direct joint involvement. Immunocytologic techniques may help in the diagnosis. The evidence linking dermatomyositis and polymyositis to malignancy was reviewed, although analysis of the ...

Two hundred forty-eight cases of melanoma accessioned from 1984 through 1985 were independently reviewed by a panel of dermatopathologists for the presence of nevomelanocytic proliferations in histologic contiguity with melanoma. One hundred ninety-seven cases remained in the sample for analysis after cases with insufficient histologic material and those diagnosed without ...

Malignant fibrous histiocytoma of the mandible has appeared frequently enough in the world literature in recent years to assume a legitimate place in the differential diagnosis of neoplastic masses of the lower jaw. This article reports a pertinent case and tabulates and correlates the findings of all cases reported thus ...

Five neoplasms were initially believed to represent primary osteosarcomas of the lung. Of the five cases, two were reinterpreted as carcino-sarcomas based on the identification of epithelial elements on further histologic sectioning and immunohistologic study in one and on immunohistologic study alone in the second. The differential diagnosis of carcinosarcoma ...

Clinically significant adrenal hemorrhage due to adrenal metastases has rarely been reported. We describe three cases of this unusual entity, two from lung carcinoma and one from sarcoma. Adrenal hemorrhage was bilateral in two patients, and was the presenting manifestation of malignancy in two. A computed tomography diagnosis of hemorrhage ...

Malignant mesothelioma of the tunica vaginalis is rare, but sometimes curable. It is similar to malignant mesothelioma of the peritoneum and of the pleura, and is likewise associated with asbestos exposure. We report a case, with correlative computed tomography, ultrasound, and gross pathology images that demonstrate tiny tumor implants studding ...

Juxtacortical liposarcoma is an uncommon entity. The purpose of this paper is to report the case of a 63-year-old man with juxtacortical liposarcoma. Liposarcomas arising as surface lesions of bone are extremely rare. Histologically, juxtacortical liposarcoma is composed of myxoid and round-cell areas. Because of the extent of compartmental involvement ...

Between January 1981 and December 1986, thoracoscopies were carried out on 152 patients in order to evaluate the diagnostic accuracy of the technique in cases of pleural effusion. All patients had previously undergone a thoracentesis together with an unguided pleural biopsy but had remained undiagnosed. Of them, 74 cases were ...

Resolving osteochondromas were previously thought to be uncommon. Two cases are presented, including the first report of a resolving solitary osteochondroma of the proximal tibia. These cases, along with previous reports, suggest resolution may occur, especially in boys under age 12 years. Surgical excision should be delayed in this group ...

The clinical and histopathological features of four cases of clear cell sarcoma of kidney (CCSK) or Bone metastasising renal tumour of childhood (BMRTC) are presented. These cases were identified among 107 primary renal tumours in childhood over a period of 15 years (1973-1987) in the Trivandrum Medical College. Of the ...

Malignant melanoma of the larynx is a rare tumour. Only 31 cases of primary laryngeal melanoma have been reported in the literature. Cady et al., (1968) found only four cases in a group of 2,500 cases of laryngeal cancer seen over a 25-year period. A case of primary malignant melanoma ...

A case with oral Kaposi's sarcoma (KS) is reported that regressed during therapy with Zidovudine (AZT) which was started 5 months after the first dermal and oral tumours were noted. After 6 months of treatment the absolute number of T-helper cells had increased from 54/microliters to 232/microliters and the ratio ...

A case of alveolar soft part sarcoma (ASPS) of the cervix uteri of a 32-year old woman is described. Its differential diagnosis from histologically similar tumours is discussed. ASPS has been reported in the cervix uteri in one instance only in the literature. In spite of their unusual localization, these ...

Malignant melanoma of the uterine cervix is an extremely rare manifestation, and neither retrospective nor prospective studies on this disease entity have been published. A patient with this disease entity is described. In addition, the data contained in 25 published case reports were collated in an attempt to clarify the ...

Malignant fibrous histiocytoma is a pleomorphic sarcoma that classically arises in the extremities and metastasizes to the lungs and regional lymph nodes. A review of the literature revealed only four previous cases of primary gastrointestinal malignant fibrous histiocytoma, all of which were treated by resection. This report describes a unique ...

A 37-year-old man with a 30-year history of recurrent anorectal ulceration developed a hemangiosarcoma of the rectum. This diagnosis was made based on histology and immunocytochemistry. We believe this is the fifth reported case of hemangiosarcoma of the rectum and is another example of a rare granulation tissue sarcoma.

Nine cases of endometrial stromal sarcoma are described. Four of the patients were categorized as having a uterine endolymphatic stromal myosis (ESM) with less than 10 mitoses per 10 HPF and five patients as having an endometrial stromal sarcoma (ESS) with more than 10 mitoses per 10 HPF. Another prognostic ...

Twenty-one Japanese cases of subungual malignant melanoma were investigated clinically and histologically. In the majority of the cases, the initial sign of the disease was confirmed to be melanonychia striata. Five cases of Clark's Level I melanoma were found in the series. Melanonychia striata had appeared as the initial sign ...

This retrospective analysis reviews the clinical experience of a major urban referral hospital with diffuse malignant pleural mesothelioma during the 14-year period from 1973 through 1986. Seventy-five cases of definite or equivocal mesothelioma were identified. There were four cases of primary malignant peritoneal mesothelioma, seven cases of benign fibrous mesothelioma, ...

A case of susceptibility to malignant hyperthermia, diagnosed by muscle biopsy during the first trimester of pregnancy, is presented. Pertinent medical history that might raise this suspicion is reviewed. The pathophysiology of malignant hyperthermia is discussed. Recent reports documenting the placental transfer of dantrolene and complications associated with dantrolene administration ...

Malignant fibrous histiocytoma is a recently recognised common sarcoma of late adult life which, rarely, may arise in the heart. Unlike the atrial myxoma, which it may mimic clinically, malignant fibrous histiocytoma is a far more aggressive tumour with a greater tendency for local recurrence and infiltration. A case of ...

This is the case report of a thirty-one-year-old woman who presented with a large skin lesion on a breast that was first thought to be a malignant or inflammatory process. After a biopsy, the lesion was diagnosed as nonspecific vasculitis. No similar case has been found in a review of ...

A case of malignant otitis externa occurring in a fit 25-year-old non-diabetic male is reported. The clinical and histological findings support this diagnosis but neither identification nor culture of Pseudomonas aeruginosa was made and the condition was bilateral. The only pathogen identified was Staphylococcus aureus which has been reported in ...

A case of uveal malignant melanoma with extensive spread to the central nervous system occurring in a 63-year-old woman with peripheral-type von Recklinghausen's neurofibromatosis was studied by light microscopy. The tumor histologically consisted of large, loosely coherent epithelioid cells with abundant eosinophilic cytoplasm and large, irregular nuclei with prominent nucleoli. ...

In contrast to Caucasians, Japanese people have a relatively high incidence of malignant melanoma in the oral cavity and volar-subungual skin. The classification of oral melanoma has not been established. We report 7 new cases of oral melanoma, with a review of 36 cases, published in Japan, between 1970 and ...

A case of epithelioid sarcoma of the penis is reported with a review of the current treatment modalities. A new method of reconstructing the penis involved with malignancy is presented. Pertinent literature is cited. Cases of epithelioid sarcoma should be published to improve the understanding of the potential of different ...

Tissue specimens obtained at autopsy from seven childhood cases of malignant histiocytosis were studied by immunohistochemistry. Clinically, the majority of the cases showed sustained fever, hepatosplenomegaly, pancytopenia, and DIC. The pretreatment diagnosis was based on their typical clinical manifestations and bone marrow smear findings. Although three patients temporarily responded to ...

Asbestos is not the only cause of malignant mesothelioma. An updated review of the literature is presented with reports on mesothelioma with unknown causes (spontaneous cases) in animals and humans and on mesothelioma in man in association with exposure to erionite-zeolite, exposure to ionizing radiation, and chronic inflammation and in ...

The association of Kaposi's sarcoma with malignant lymphoreticular diseases and immunosuppressive therapy is well documented. This report describes an elderly man who presented with fulminant Wegener's granulomatosis that responded to treatment with cyclophosphamide and corticosteroids. Rapidly progressing cutaneous Kaposi's sarcoma developed ten weeks after the start of immunosuppressive therapy yet ...

Hypereosinophilic syndrome (HES) is a disease process of unknown pathogenesis. Although some cases are believed to be primary hematologic malignancies, this issue remains unsolved. We present a case of HES in whom we have observed a clone of cytogenetically abnormal cells in the bone marrow in parallel with a clinical ...

A case of primary Kaposi's sarcoma of the lymph node (single node involvement) is reported on here. It occurred in a white, Italian boy 10 years of age. An extensive review of the literature showed that this was only the second childhood case of the disease among non-acquired immune deficiency ...

Malignant melanomas of the penis and male urethra are uncommon lesions. We report 3 new cases of male urethral melanoma and 1 case of penile melanoma, bringing the total numbers of reported cases to 26 and 57, respectively. The literature is reviewed, and biological, histopathological and therapeutic considerations are analyzed.

We report 3 cases of abdominal malignancy with urinary tract obstruction and pyelosinus extravasation. Urinomas were present in 2 cases. The computed tomographic findings are emphasized, including the distribution of the extravasated urine reflecting the partitioning in the perirenal space. The cases presented within an eighteen-month period suggest pyelosinus extravasation ...

The pathologic and clinical findings in cases of desmoplastic melanoma of the head and neck seen at the Mayo Clinic in Rochester, Minnesota, during the past 20 years were analyzed. The nine cases acceptable for study included six usual and three neurotropic variants as defined by light microscopic criteria. Immunopathologic ...

A biphasic synovial sarcoma occurring in the wall of a pathologically thickened femoral vein was diagnosed in a 34-year-old woman. This sarcoma was resected together with removal of a thrombus. A local recurrence was seen 5 years later, but the patient is alive and well 11 years after the first ...

Malignant fibrous histiocytoma arising in bone infarcts has only been recently recognized as a pathologic entity. Eighteen cases have been reported prior to this one. A case of a malignant fibrous histiocytoma developing in a 58-year-old man with idiopathic medullary bone infarcts in the distal femurs is presented along with ...

Primary malignant melanomas of the nasal cavity are rare, as only 400 cases have been reported to date. The present paper describes two cases recently seen in Caucasian women. The authors point out the difficult clinical diagnosis, as the symptoms are rather aspecific. From the histopathological point of view, diagnosis ...

The clinical and pathologic findings of two patients with malignant ectomesenchymomas of soft tissue are reported. Malignant ectomesenchymomas are a composite of ganglion cells or neuroblasts and one or more malignant mesenchymal elements, usually rhabdomyosarcoma. Our first case was composed of ganglioneurosarcoma plus rhabdomyosarcoma, the second composed of neuroblastoma plus ...

This report describes a patient with liposarcoma of the spermatic cord. The clinical presentation, pathogenesis, and prognosis of this unusual sarcoma are reviewed. The low-grade malignant potential and irregular growth characteristics of this liposarcoma render preoperative diagnosis difficult. The role of radical orchiectomy, retroperitoneal lymph node dissection, radiation therapy, and ...