Personalized medicine in oncology is maturing and evolving rapidly, and the use of molecular biomarkers in clinical decision-making is growing. This raises important issues regarding the safe, effective, and efficient deployment of molecular tests to guide appropriate care, specifically regarding laboratory-developed tests and companion diagnostics. In May 2011, NCCN assembled ...

PURPOSE: The aim of the study was to identify alterations in the auditory processing of patients with chronic cerebellar disease using a dichotic listening test with alternating dissyllables, also known as the Staggered Spondaic Word (SSW) test. MATERIALS AND METHODS: A study involving a control group of 20 subjects and ...

The Synthetic Sentence Identification (SSI) test assesses central auditory pathways by measuring auditory and visual sensitivity and testing selective attention. Cerebellum activation in auditory attention and sensorial activity modulation have already been described. Assessing patients with cerebellar lesions alone using the SSI test can confirm the role of the cerebellum ...

PURPOSE:: Documenting high analytic validity of the molecular diagnostic test for Huntington disease is important because of counseling implications. This dominantly inherited adult onset disorder (prevalence of three or more per 100,000) is characterized by chorea, ataxia, and personality changes. The molecular basis is excessive CAG repeats in the HTT ...

Purpose:Documenting high analytic validity of the molecular diagnostic test for Huntington disease is important because of counseling implications. This dominantly inherited adult onset disorder (prevalence of three or more per 100,000) is characterized by chorea, ataxia, and personality changes. The molecular basis is excessive CAG repeats in the HTT gene.Methods:External ...

Acquired pendular nystagmus (APN) occurs with multiple sclerosis (MS) and oculopalatal tremor (OPT); distinct features of the nystagmus have led to the development of separate models for their pathogenesis. APN in MS has been attributed to instability in the neural integrator, which normally ensures steady gaze. APN in OPT may ...

INTRODUCTION: People worldwide depend upon daily fish consumption as a major source of protein and other nutrients. Fish are high in nutrients essential for normal brain development, but they also contain methylmercury (MeHg), a neurotoxicant. Our studies in a population consuming fish daily have indicated no consistent pattern of adverse ...

To study the deleterious effects of ketamine and the potential interaction effects between ethanol and ketamine on the cerebellum, functional magnetic resonance imaging (fMRI) tests were performed on the habitual ketamine users (n = 3) when they flexed and extended their upper limbs. Another fMRI test was performed on the ...

This work presents two analytical methods developed for measuring three components of polyethersulphone (PES) and applying them to the migration testing of 30 baby bottles made of PES. The study also provides migration results under the same conditions for bisphenol A (BPA) from 40 polycarbonate baby bottles using a well-established ...

The aim of this study was to find whether 1-Hz cerebellar repetitive transcranial magnetic stimulation (rTMS) could affect upper limb movement in early-stage Parkinson's disease (PD). Twenty patients with PD underwent one session with real and one with sham rTMS. rTMS (1 Hz, 600 pulses) was targeted at the right lateral ...

Modeling juvenile traumatic brain injury (TBI) in rodents presents several unique challenges compared to adult TBI, one of which is selecting appropriate sensorimotor behavioral tasks that enable the assessment of the extent of injury and recovery over time in developing animals. To address this challenge, we performed a comparison of ...

The emergence of Clostridium difficile ribotype 027 raised the question of sporicidal surface disinfectants are also effective against spores of C. difficile ribotype 027. Three surface disinfectants based on magnesium monoperoxyphthalate hexahydrate (Dismozon pur), a combination of (ethylenedioxy)dimethanol, glutaral and benzyl-C12-18-alkyldimethylammonium chlorides (Kohrsolin extra) and a combination of glutaral, benzyl-C12-18-alkyldimethylammonium ...

Use of the QuantiFERON®-TB Gold In-Tube assay (QFT-GIT) in remote areas is limited by the need to incubate blood samples within 12 h of collection. PortaTherm™ is a portable, electricity-free, phase-change incubator previously used for field collection of microbiological samples. To determine whether the PortaTherm can be used for the ...

Introduction:  The study was designed to evaluate whether there was a statistically significant effect between evacuated glass tubes and plastic tubes on prothrombin time (PT) and activated partial thromboplastin time (aPTT). Methods:  Blood samples were drawn into four different tubes from three patient populations-apparently healthy patients, patients on oral anticoagulant ...

The modified truncated singular value decomposition (MTSVD) unfolding method is applied to obtain primary spectra for X-ray tubes in radiodiagnostic. Three parameters - voltage, anode angle and filter thickness - of the tube are tested. Unfolded spectra are compared with theoretical extracted from IPEM-78 catalogue. A 2σ error criterion is ...

The Duopath® Cereus Enterotoxins test (Merck KGaA) is a newly developed gold-labeled lateral flow immunoassay for the detection of Bacillus cereus enterotoxins. The test uses monoclonal antibodies (MAbs) against the L(2) component of hemolysin BL (Hbl) and NheB of the non-hemolytic enterotoxin (Nhe), respectively. The inclusivity and exclusivity of the ...

Recent publications have suggested that cylindrically shaped drug-delivery carriers have an advantage over carriers based on spherical particles in both blood circulation and cell internalization rates. For this reason, this article introduces a method to fabricate hollow, uniform, biodegradable chitosan nano test tubes for applications in drug delivery. A nanoporous ...

To review and discuss the airway leak test in predicting extubation failure in critically ill infants and children. A critical appraisal with literature review of Wratney AT, Benjamin DK Jr, Slonim AD, et al: The endotracheal tube air leak test does not predict extubation outcome in critically ill pediatric patients. ...

BACKGROUND: This study compared the fluid leakage in the new 'tapered' shaped against the classic 'cylindrical' shaped tracheal tube cuffs when placed in different sized tracheas. METHODS: The 7.5 mm internal diameter (ID) tracheal tube cuffs-Tapered Seal Guard (TSG), Standard Seal Guard (SSG), Hi-Lo, Microcuff, Ruesch, and Portex Profile-were compared ...

The Quantiferon Gold tuberculosis tube test is a sensitive and specific way to diagnosis latent and active tuberculosis. The test is easy to administer and potentially can be used under field conditions and in a remote analytical laboratory. We screened an endemic population under field conditions and transferred our specimens ...

OBJECTIVE: To assess the usefulness of One Tube Osmotic Fragility Test (OTOFT) for "on the spot" screening of rural families with history of thalassaemia. METHODS: It was an "observational cross-sectional" study conducted at Pathology Department of PNS Shifa Hospital, Karachi and included all available members of three families from the ...

The diagnosis of autoimmune hemolytic anemia (AIHA) is based on a positive direct antiglobulin test (DAT), which is performed using various methods with different sensitivities. Recently, mitogen-stimulated (MS)-DAT was suggested to be able to identify latent anti-erythrocyte autoimmunity. Traditional methods (tube, microcolumn, and solid phase) and MS-DAT were compared in ...

Discard tubes have traditionally been obtained when drawing samples for coagulation testing to avoid potential tissue factor activation of coagulation in the first tube that may lead to inaccurate results. Although discard tubes are no longer required for prothrombin time and partial thromboplastin time, the practice is still recommended for ...

OBJECTIVE: To assess if neonatal endotracheal tube (ETT) position improved with introduction of the NeoBar. METHODS: This retrospective study compared two cohorts of intubated neonates and their x-rays. During the first 2-month study period, ETTs were secured with tape only--the 'Tape-only' period; during the second study period, they were secured ...

Identification of optimal microphone configurations and instrumentation is underway as a continuous process improvement effort at ATK Space Systems, where large solid rocket motors (SRMs) have been tested for decades. Rocket motor tests provide a unique environment which cannot be fully duplicated in a laboratory. This is especially true for ...

The C-MAC videolaryngoscope is a novel intubation device that incorporates a camera system at the end of its blade, thereby facilitating obtaining a view of the glottis without alignment of the oral, pharyngeal and tracheal axes. It retains the traditional Macintosh blade shape and can be used as a direct ...

The Clinical and Laboratory Standards Institute (CLSI) recently abandoned its recommendation for drawing a discard tube when performing a prothrombin time (PT)/international normalized ratio (INR) or an activated partial thromboplastin time (APTT). Because there is currently no evidence that a discard tube is necessary for more specialized coagulation assays, we ...

Polypropylene microtubes (tubes) are generally used for bio-material tests in addition to PCR tests such as genetically modified organism (GMO) testings. However, the choice of suitable tubes is quite important, because it might influence the results: DNA binding and/or elution of chemical substances sometimes occurs. In this study, we established ...

Several chemicals were studied to suppress the damage due to a stress corrosion cracking (SCC) of the steam generator (SG) tubes in nuclear power plants. SCC tests were carried out to investigate the performance of TiO2 on several types of SG tube materials. The SCC tests were conducted by using ...

Whole blood aggregometry on the is a simple, fast and standardized method and it is widely used to assess platelet function under antiplatelet therapy. Reference ranges and a cut-off value as a measure of ASA response were established by measuring arachidonic acid induced aggregation (ASPI-test) in healthy volunteers and cardiac ...

This study aimed to test the sterility of new unused orthodontic buccal tubes received from manufacturers. Four different types of buccal tubes were used straight from the manufactures package without any additional sterilizing step. Of these buccal tubes tested, three genera of bacteria, implicated as opportunistic pathogens, namely Micrococcus luteus, ...

BACKGROUND: The ideal identification of Staphylococcus aureus clinical isolates requires a battery of tests and this is costly in resource limited settings. In many developing countries, the tube coagulase test is usually confirmatory for S. aureus and is routinely done using either human or sheep plasma. This study evaluated Mannitol ...

The test of the inner tube integrity is an important checklist prior to the safe use of Bain's breathing system. This is because the major concern with the use of Bain's circuit is the potential malfunctioning of the circuit due to avulsion of the inner fresh gas delivery tube at ...

OBJECTIVE: The objective of this study was to evaluate the sealing ability of AH Plus, Epiphany, Acroseal, Endofill, and Polifil after active lateral condensation technique, by using a bacterial test, during 64 days. STUDY DESIGN: One hundred bovine incisors were cleaned and shaped; then they were filled with the endodontic ...

Endotracheal tube (ETT) insertion is the primary method of definitive airway protection and control in critically ill patients. Detection of ETT malposition in a timely fashion is crucial in both elective and emergent intubation. In this review, we describe classic tests and highlight several new technologies that may assist the ...

OBJECTIVE: To assess the acetaminophen absorption test (APAT) for use in determining function of the reticular groove reflex in lambs. ANIMALS: 12 Baluchi lambs. PROCEDURES: 2 consecutive APATs were performed at each of 3 developmental stages (stage 1, before weaning; stage 2, at weaning; and stage 3, after weaning). Lambs ...

During flow testing of a deep, 1927-m, gravel packed screen completed well, it became apparent that well development was needed to increase productivity. A hydrojetting system using coiled tubing in combination with simultaneous pumping was developed and tested and found to be successful. To verify whether the jetting improved the ...

Cyril M. Harris authored a paper in 1955 titled "Acoustical Properties of Carpet" in which absorption coefficients for carpet were examined according to specific parameters, including fiber content. Since then, new fibers and blends have been introduced into the carpet industry. This study aims to compare absorption coefficients found from ...

Why infer evolution when you can watch it happen in real time? This is the basic premise of using populations of fast-replicating microorganisms in test tubes to study evolution. The approach, known as experimental evolution, has provided a way of testing many of the key hypotheses that arose from the ...

PURPOSE: A Perth metropolitan hospital group standardized changes to nasogastric tube placement, including removal of the "whoosh test" and litmus paper, and introduction of pH testing. DESIGN AND METHODS: Two audits were conducted: bedside data collection at a pediatric hospital and a point-prevalence audit across seven hospitals. RESULTS: Aspirate was ...

BACKGROUND: Middle ear barotrauma (MEBT) is the most common medical complication in diving, aviation, and hyperbaric medicine. Eustachian tube dysfunction (ETD) quantifies the inability to open the eustachian tube (ET), risking MEBT. Surfactant administration improved ET function and efficaciously treated otitis media in a host of animal models. We performed ...

A double diaphragm shock tube facility for studying liquid-spray atomization and combustion-related phenomena at elevated pressures and temperatures is described. The present shock tube is specifically intended for the investigation of fundamental processes related to fluid disintegration and mixing under realistic engine conditions. Special features of the facility include a ...

Destructive analyses of impregnated-cathode assemblies from an ion thruster life test were performed to characterize erosion and degradation after 30,472 h of operation. Post-test inspection of each cathode included examination of the emitter (insert), orifice plate, cathode tube, heater, anode assembly, insulator, and propellant isolator. The discharge-cathode assembly experienced significant ...

OBJECTIVE: To evaluate whether a simple aspiration test can be used to accurately confirm the correct placement of fine-bore feeding tubes in the oesophagus and prevent their inadvertent placement in the bronchial tree. DESIGN: We conducted an ethically approved, randomised, blinded trial to assess the accuracy of a simple aspiration ...

The aim of this study was to compare the volumetric expansion of gutta-percha in the presence of eugenol or physiologic saline over time. Sections of gutta-percha cones were scanned to determine their total volume and surface area. They were then placed in sealed test tubes with either 2 microL eugenol ...

In October 2007, an 18-year-old woman with no cardiac history was admitted to the emergency department for a major epigastric pain. The chest pain led to assay cardiac troponin I (cTnI) with the emergency department point-of-care testing analyzer (Stratus CS), which disclosed a value of 0.70 ng/mL, discordant with the ...

The performance of the occlusion and Pethick tests in detecting faulty inner tubes in co-axial circle and Bain systems was compared. Twelve co-axial circle and 12 Bain anaesthetic breathing systems were tested using the occlusion and the Pethick tests. For each system, three tubes were intact, and the remaining nine ...

BACKGROUND: Antibody titration is difficult to standardize. We investigated whether a detailed, uniform procedure for antibody titration would reduce variation in both tube-based and gel card titres in an international study. METHODS: Laboratories (n = 35) tested proficiency testing material provided by the College of American Pathologists each according to ...

A comparison between the two sound transmission loss (STL) measurement techniques using an impedance tube (i.e. two-load method and anechoic termination method) is presented. A modified B&K type 4206 impedance tube has been designed and built. STL tests have been carried out for three homogeneous and isotropic materials with disk-type ...

Spinal muscular atrophy (SMA) is characterized by selective loss of alpha-motor neurons and is caused by homozygous loss or mutation in the survival motor neuron (SMN1) gene. Loss of SMN1 is partially compensated by the copy gene, SMN2. Currently, there are no specific treatments for SMA. Key features of SMA ...