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Mooi Wolter J WJ Department of Pathology, VU University Medical Center Amsterdam, Amsterdam, The - - 2014
On the basis of a critical review of published literature, it is concluded that there is as yet insufficient evidence to conclude that the melanocytic lesion, which is currently known as "lentiginous melanoma," is a full-fledged melanoma, with the capacity to metastasize to distant sites and to cause the demise ...
Argenziano Giuseppe G Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio, Emilia, - - 2014
The development of new primary melanomas in patients treated with vemurafenib has been reported recently in a study by Perier-Muzet et al. The primary outcome of the study was to describe the dermoscopic changes that prompted excision of those melanomas. However, the crucial point raised by the study is the ...
Bouillet Laurence L National Reference Centre for Angioedema (CREAK), Internal medicine department, Grenoble University Hospital, BP 217 38043 Grenoble cedex 09 France, Unité Inserm 1036, CEA, Université de médecine Joseph-Fourier, Grenoble, - - 2014
The aetiologies of recurrent angioedema (AE) comprise the frequent histaminergic AE and the rare bradykinin-mediated AE. Diagnosis must be done carefully because they do not have the same treatment. Diagnosis strategy is clinical. The most specific symptoms for bradykinin AE are: isolated AE without wheals, long duration of the attack, ...
Xing Yanfen Y Department of Radiology, People's Hospital of LaiWu - - 2014
Recent studies have revealed a potential relationship between the presence of ground glass opacity (GGO) on regular computerized tomography(CT) and adenocarcinomas. To investigate features of pre-invasive lung adenocarcinoma lesions on thin-section computerized tomography (CT). We evaluated 59 cases of atypical adenomatous hyperplasia (AAH) and 35 cases of adenoma in situ ...
Nguyen T T Houston VA HSR&D Center of Excellence, Baylor College of Medicine, Houston, Texas, USA; Department of Medicine, Baylor College of Medicine, Houston, Texas, - - 2014
Few studies have examined the temporal trends of length in newly diagnosed Barrett's esophagus (BE) and arrived at conflicting results. The aim of this study was to identify whether there has been a change over time in the length of BE at the time of diagnosis. This is a retrospective, ...
Kim J S JS Department of Dermatology, Hanyang University Guri Hospital, Guri, - - 2014
Lipomembranous changes are distinctive histopathological findings, which include the presence of cystic cavities lined by crenulated, hyaline membranes in adipose tissue. It is likely that ischaemia is fundamental to the development of these lesions, and that lipomembranes are formed from the products of degenerating fat cell membranes by some unknown ...
Sinnya Sudipta S Dermatology Research Centre, School of Medicine, University of Queensland, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Queensland, - - 2014
We present a case of verruciform xanthoma ((VX) of the penis in an elderly man in whom an asymptomatic papule on his foreskin was noted during a routine clinical examination. VX is a rare, benign condition with a predilection for the oral cavity and clinically presents as isolated, painless mucosal ...
Dodd Leslie G LG Department of Pathology, University of North Carolina at Chapel Hill, North - - 2014
Pleomorphic liposarcoma represents one of the rarest variants of liposarcoma. It has a poor prognosis and unlike other variants of liposarcoma, lacks a molecular or genetic signature. Histologic studies of pleomorphic liposarcoma have defined this lesion as a high grade sarcoma, which contains a variable number of lipoblasts. We describe ...
Li Yun-Hong YH Yun-Hong Li, Xu Li, Xiao-Ping Zou, Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, - - 2014
Primary malignant melanoma of the esophagus (PMME) is a malignant tumor which occurs in the melanin cells of esophageal mucosal epithelial basal layer. PMME is a rare disease with an extremely poor prognosis. PMME represents only 0.1% to 0.2% of all esophageal malignant tumors. Dysphagia, retrosternal or epigastric discomfort or ...
Park Hyo Jin HJ Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Gyeonggi, - - 2014
"Atypia of undetermined significance" (AUS) in the Bethesda System for Reporting Thyroid Cytopathology is a heterogeneous category for cases that cannot be easily classified into benign, suspicious, or malignant. This study evaluated whether cytomorphology-based subcategorization could better predict the malignancy risk in cases designated as AUS, and how the subcategories ...
Bohman Summer L SL Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, United - - 2014
Angiomatoid fibrous histiocytoma, a fibrohistiocytic tumour of intermediate malignancy that usually presents on extremities of young patients, has a broader clinical/histological spectrum than is widely appreciated. We summarise our experience with an emphasis on unusual features.Twenty-seven cases were analysed for clinical and histological features, including immunohistochemistry and FISH for rearrangements ...
Hobbs Hasan A HA 1 Department of Radiology, Division of Neuroradiology, Duke University Medical Center, DUMC Box 3808, Durham, NC - - 2014
OBJECTIVE. The Society of Radiologists in Ultrasound (SRU) recommendations on thyroid nodules are intended to "diagnose thyroid cancers that have reached clinical significance, while avoiding unnecessary tests and surgery in patients with benign nodules." The aim of our study was to determine the proportion of thyroid nodules undergoing ultrasound-guided fine-needle ...
Andreassi Lucio L Professor Emeritus, University of Siena, Italy. Electronic address: - - 2014
The genitalia may be the site of non-infectious inflammatory lesions that are generally manifested as balanoposthitis and vulvovaginitis. In men, these forms constitute 50% of all balanoposthitis forms, and in women, vulvovaginitis frequency is even higher. They consist of genital locations of general skin diseases, such as psoriasis, lichen planus, ...
Panwar Aru A Division of Head and Neck Surgery, University of Nebraska Medical Center, Omaha, NE, - - 2014
Premalignant lesions of the oral cavity present as visibly abnormal areas of mucosa and may be a source of significant anxiety for the patient and the clinician. Suspicious lesions should be biopsied to evaluate for dysplasia. The risk of malignant transformation may relate to patient characteristics, environmental risk factors and ...
An Jingang J From the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Peking University, Beijing, People's Republic of - - 2014
Surgical ciliated cysts are an uncommon complication of maxillary surgery. We report a case of such a cyst that developed at the right medial canthal region 10 years after the surgical treatment of a severe midfacial fracture. The cyst presented as a round cystic lesion protruding through a small bony ...
Verma Prashant P Department of Dermatology and STD, University College of Medical Sciences (University of Delhi) and Associated Guru Teg Bahadur Hospital, Delhi, - - 2014
Tumid lupus erythematosus (LE) is a rare variant of lupus erythematosus, which often follows a favorable course. A case of a young woman is illustrated, who presented with an asymptomatic erythematous, solitary plaque over her face. Histopathological and direct immunofluorescence examination established a diagnosis of tumid lupus erythematosus. She responded ...
Kaski Diego D Department of Neuro-otology, Charing Cross Hospital, , London, - - 2014
Benign paroxysmal positional vertigo (BPPV) is the commonest cause of dizziness. It is characterised by brief episodes of vertigo and imbalance with nystagmus. The direction of nystagmus allows the identification of the culprit semicircular canal. As it is readily treatable-and often curable-BPPV should not be missed. Although recurrent episodes of ...
Guinovart R M RM Departamento de Dermatología, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain. Electronic address: - - 2014
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare disease characterized by single or multiple angiomatous lesions typically located on the scalp and the face. We present a retrospective analysis of 9 cases of ALHE. The lesions appeared largely as multiple grouped papules or, in some cases, subcutaneous nodules, located mainly ...
Agarwal Sunil S NIMS Medical College, Department of General Surgery, Jaipur, Rajasthan 303121, India. Electronic address: - - 2014
Buschke-Löwenstein tumour, also known as Giant condyloma acuminatum, is a rare, sexually transmitted disease that affects ano-genital region. BLT is a slow growing cauliflower-like tumour, locally aggressive and destructive. Human papillomavirus has been identified as an important contributory factor in the development of tumour. A 45 year uncircumcised male presented ...
Tavares Tatiane F TF Departamento de Psicologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil. Avenida Bandeirantes, 3900; 14040-901, Ribeirão Preto, São Paulo, Brasil. Electronic address: - - 2014
The amygdala has been implicated in a variety of motivational and attentional functions related to appetitive learning. Some studies showed that electrolytic lesions of the amygdaloid complex disrupted reinforcement omission effects (ROEs). However, recent studies that investigated ROEs employing neurotoxic lesions in specific amygdala areas - the central nucleus (CeA) ...
Renard Dimitri D Department of Neurology, CHU Nîmes, Hôpital Caremeau, , Nîmes, - - 2014
Lesions of the corpus callosum (CC) are seen in a multitude of disorders including vascular diseases, metabolic disorders, tumours, demyelinating diseases, trauma and infections. In some diseases, CC involvement is typical and sometimes isolated, while in other diseases CC lesions are seen only occasionally in the presence of other typical ...
Gupta Rajib Kumar RK a University of Tennessee Health Science Center, - - 2014
Abstract Juvenile myelomonocytic leukemia (JMML), belonging to the category of myeloproliferative/myelodysplastic syndromes, is a rare pediatric hematological malignancy with frequent skin manifestations commonly in the form of rashes. However these rashes are not always biopsied and their immunophenotype studied in details. We report one such case in a 2 year ...
Yagerman Sarah E SE Weill Cornell Medical College, New York, - - 2014
Many melanomas are of a diameter smaller than 6 mm and may lack classical asymmetry, border irregularity and colour variegation (ABCD). The objectives of this article are to characterise the fidelity of melanomas diagnosed in a high-risk clinic to the ABCD and to review potential methods for early clinical detection of ...
Canal Laia L Departments of *Dermatology, †Rheumatology, and ‡Pathology, Hospital Universitari de Bellvitge, Barcelona, - - 2014
: Cutaneous lesions in Whipple disease (WD) are infrequent, and the histological findings are usually nonspecific. Specific cutaneous lesions have rarely been described and usually involve the subcutaneous fat. We report a patient diagnosed with WD, who developed multiple small subcutaneous nodules after antibiotic treatment was administered. In addition to ...
Yu Li L Department of Pathology, The First Affiliated Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, 510080, People's Republic - - 2014
Aberrant expression of high mobility group box 1 (HMGB1) is associated with tumor development and progression. The current study was conducted to evaluate the significance of HMGB1 immunostaining on cell block (CB) preparations in the diagnosis of neoplastic and preneoplastic lesions of the cervix. The CBs were prepared from 157 ...
Henry Thomas R TR From the University of Minnesota Medical School, - - 2014
Nonlesional extratemporal lobe epilepsy (ETLE) often persists following resection of the site of ictal onset, localized with definitive intracranial EEG recordings.(1,2) In lesional ETLE, however, lesionectomy with resection of a single electrophysiologically defined ictal onset (ictogenic) zone often stops seizures immediately and permanently.(1,2) In temporal lobe epilepsy (TLE), a single ...
Barron Stacey S Dept of Pathology, Magee-Womens Hospital of UPMC, 300 Halket St, Pittsburgh, PA 15213; - - 2014
Objectives: To examine data correlating high-risk human papillomavirus (hrHPV) results in patients with both low-grade squamous intraepithelial lesion (LSIL) and atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion (ASC-H) cytology findings (LSIL-H) with follow-up histopathology. Methods: A total of 494 LSIL-H ThinPrep (Hologic, Marlborough, MA) cases with hrHPV testing ...
Dayal Seema S Additional Professor & Head (Forensic Medicine & Toxicology) UP RIMS & R, Saifai, Etawah - 206130 India; - - 2014
Objectives: To examine the clinicopathologic profile of leiomyoma in surgically removed uteri in a rural tertiary care hospital of north India between January 2008 and August 2012. Methods: Fibroids are the most common benign tumors of reproductive-age women, with the genital tract being the most common site for tumors. The ...
Rossi Esther Diana ED Division of Anatomic Pathology and Histology, Catholic University of the Sacred Heart, Agostino Gemelli School of Medicine, Rome, - - 2014
The current study was conducted to investigate the role of thyroid fine-needle aspiration cytology (FNAC) in the authors' pediatric series. Thyroid pediatric FNAC has been reported to have conflicting sensitivity and specificity in different series. The authors evaluated their thyroid cytological series mainly for the categories of 1) follicular/indeterminate neoplasms ...
Bekers Elise M EM Department of Pathology, Radboud University Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands, - - 2014
Malignant melanomas are known for their remarkable morphological variation and aberrant immunophenotype with loss of lineage-specific markers, especially in recurrences and metastases. Hot spot mutations in BRAF, NRAS, GNAQ, and GNA11 and mutations in KIT are oncogenic events in melanomas. Therefore, genotyping can be a useful ancillary diagnostic tool. We ...
Seo Jae Young JY Department of Radiology, Research Institute of Radiological Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, - - 2014
The BRAF(V600E) mutation test has been more effective in thyroid nodules with suspicious US features than ones without suspicious features. Therefore, we investigated the role of the BRAF(V600E) mutation as an additional study to cytology in diagnosing a thyroid nodule without suspicious US features. This study was performed at Severance ...
Temple-Oberle Claire F CF Divisions of Plastic Surgery and Surgical Oncology, University of Calgary, Calgary, Alberta, Canada; Tom Baker Cancer Centre, Calgary, Alberta, - - 2014
Intra-lesional interleukin-2 (IL-2) is effective in treating in transit melanoma metastases. Results from multiple studies were examined to evaluate the efficacy of IL-2 for in transit disease. In the published literature, complete response ranged from 0% to 69% per patient, and 41% to 96% per lesion, with excellent tolerability. Combining ...
J Lai L Division of Anatomical Pathology, Department of Pathology - - 2014
A 55-year-old healthy Caucasian female, on no medication, was seen by a dermatologist because of a patchy, slightly indurated, and violaceous eruption involving her neck and trunk. The clinical impression was of granuloma annulare. Over a period of several months the violaceous lesions became atrophic with loss of colour and ...
Wakasa Satoru S Department of Cardiovascular and Thoracic Surgery, Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo, 060-8638, - - 2014
Radiofrequency ablation (RFA) makes the Cox-Maze procedure less complicated but cannot always achieve transmural lesions. In this study, we assessed whether repeated application of RFA could improve histological transmurality even in thick lesions. Left atrial appendages (LAA) amputated from 20 consecutive patients (age 68 ± 9 years, 9 males) who underwent the Cox-Maze ...
Panwar Aru A Division of Head and Neck Surgery, University of Nebraska Medical Center, Omaha, NE, - - 2014
Premalignant lesions of the oral cavity present as visibly abnormal areas of mucosa and may be a source of significant anxiety for the patient and the clinician. Suspicious lesions should be biopsied to evaluate for dysplasia. The risk of malignant transformation may relate to patient characteristics, environmental risk factors and ...
Luciano Randy L RL Yale University School of Medicine, New Haven, CT; and Section of Nephrology, Yale University School of Medicine, New Haven, - - 2014
Leukemia and lymphoma are hematologic malignancies that can affect any age group. Disease can be aggressive or indolent, often with multiorgan system involvement. Kidney involvement in leukemia and lymphoma can be quite extensive. Acute kidney injury (AKI) is quite prevalent in these patients, with prerenal and acute tubular necrosis being ...
Lin Guo-Hao - - 2014
A number of diagnostic and management challenges exist for achieving complete regeneration of large through-and-through periapical lesions. An unfavorable endodontic outcome may occur as a result of uncontrolled infection or unpredictable bone healing. This article presents a case with a 15 × 15-mm through-and-through periapical lesion and persistent gingival swelling. ...
Elsaid Nada N Chelsea and Westminster Hospital, London, - - 2014
A 55 -year-old Asian man was seen in the emergency department with bleeding per rectum. He was a teetotaller and had no previous abdominal surgery. He did, however, report a change in bowel habit towards constipation. He underwent colonoscopy which revealed a lesion, highly suspicious of malignancy, in the caecum. ...
Inaba Shinji S Cardiovascular Research Foundation, New York, New York; Columbia University Medical Center, New York, New - - 2014
This study investigated coronary artery remodeling patterns associated with clinical outcomes. In the prospective, multicenter PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree: An Imaging Study in Patients With Unstable Atherosclerotic Lesions) study, reported predictors of nonculprit lesion (NCL) major adverse cardiac events (MACE) were ...
Gupta Seema S Department of Radiotherapy, C.S.M. Medical University, Chowk St., Lucknow 226003, India. - - 2014
Primary mucosal malignant melanomas of the nose are rare, accounting for only 0.3 to 2% of all cases of malignant melanoma and about 4% of all head and neck melanomas. The amelanotic variant of mucosal malignant melanoma is even more rare, and the prognosis is poor. This variant usually arises ...
McKinnon Brett D BD Department of Obstetrics and Gynecology, Inselspital, Berne University Hospital, University of Berne, Effingerstrasse 102, 3010 Berne, - - 2014
Endometriosis is an estrogen-dependent disease that can lead to chronic pain and subfertility. Endometriotic lesions found in different locations are heterogeneous and may represent a collection of related but distinct conditions. Whether there is a relationship between hormonal contraceptive (HC) use and endometriosis is still controversial. The purpose of this ...
Devi Ramisetty Sabitha RS Department of Oral Pathology, St. Joseph Dental College, Duggirala, Eluru, Andhra Pradesh, - - 2014
Benign oropharyngeal tumors are far less common compared to malignant tumors. Oropharyngeal papilloma is present in adults. Squamous papillomas are exophytic masses of oral cavity. When they occur on the palate they are most often asymptomatic and benign. Pedunculated squamous papillomas usually arise from the soft palate, tonsil, or the ...
Cardoso Lyzete Berriel LB Bauru Dental School, University of São Paulo, - - 2014
The melanocytic nevus is a benign and focal proliferation of nevus cells that can be congenital or acquired. Intraoral lesions are uncommon, and the etiology and pathogenesis are poorly understood. The occurrence rate of oral compound nevus is about 5.9% to 16.5% of all oral melanocytic nevi. A 22-year-old male ...
Oros Michelle L ML Temple University - - 2014
A healthy 66 year-old man presented with a complaint of changes within a nodule on the scalp, which had first appeared over 10 years prior. He had no previous history of skin cancer. On physical examination a solitary, asymmetric, purple-black nodule with irregular borders was identified on the right vertex ...
Ponnurangam Vinoth N VN Department of Pediatrics, Sri Ramachandra Medical College, Chennai, Tamil Nadu, - - 2014
Cutis marmorata telangiectatica congenita (CMTC) is an uncommon, congenital, vascular malformation, characterised by a fixed, generalised or localised, reticulate erythematous rash. We report an eighty day old male child who presented with the above lesion involving the left upper and lower limbs with underlying atrophic changes.
Jayam Cheranjeevi C Department of Paediatric Dentistry, College of Dental Science and Research Center, Ahmedabad, Gujarat, - - 2014
Odontomes are hamartomatous growths of odontogenic origin. Odontomes usually do not erupt into oral cavity and can cause several difficulties like swelling, displacement of teeth and adjacent structures, cystic changes and carcinomatous transformation. Odontomes are treated by surgical removal. Dentigerous cysts arise due to accumulation of fluid between reduced enamel ...
Ting Francis F St Vincent's Hospital, 390 Victoria Street, Darlinghurst, Sydney, NSW 2010, Australia. Electronic address: - - 2014
We present, to the best of our knowledge, the first published case report of a satellite lesion within the bladder from enteric type urachal adenocarcinoma (UA). Our case report involves a 38-year-old man from the Solomon Islands who underwent open partial cystectomy for UA. However, resection margins were positive due ...
Zhang Guobin G Department of Interventional and Diagnostic Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University Shanghai 200233, - - 2014
To investigate and analyze the typical CT findings of salivary gland lymphoepithelial carcinoma. CT findings in 8 patients with lymphoepithelial carcinoma (LEC) in salivary gland were studied retrospectively. Surgical resection was performed in all cases. 8 cases were subdivided to primary tumor and secondary tumor. In primary tumor group, 5 ...
Sakuraba Atsushi A 0000-0003-2519-6129 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan ; Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, The University of Chicago, 5841 S. Maryland Avenue, MC 4076, Chicago, IL 60615, - - 2014
Background. Crohn's disease (CD) may involve any part of the gastrointestinal tract. We assessed the prevalence and features of upper gastrointestinal (UGI) lesions in CD. Methods. This was a retrospective study that included 138 CD patients that underwent esophagogastroduodenoscopy (EGD). The rate of Crohn's specific endoscopic lesions in the esophagus, ...
Kohli Supreethi S Department of Radiodiagnosis, ESI model hospital, Basaidarapur, New Delhi, - - 2014
Malignant melanoma of the rectum is an extremely rare disease. It typically presents in the fifth or sixth decade of life with nonspecific complaints such as rectal bleeding or anal pain. A timely diagnosis of anal melanoma is made even more difficult by the fact that most of the lesions ...
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