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Vieth Michael M Insitute of Pathology, Klinikum Bayreuth, Bayreuth, - - 2014
NSAID and ASA intake for various reasons is a widespread worldwide phenomenon. The first gastroscopic observation of ASA effects in the stomach dates back to 1938. Up till the beginning of the 1990 s before the era of Helicobacter eradication 70% of all gastric ulcers were connected to Helicobacter infection. From ...
Rodríguez Carlos E CE Department of Animal Health, Disney's Animal Kingdom®, Orlando, - - 2014
Vitamin A deficiency is a recently recognized nutritional disease in amphibians fed insect-based diets. The classic pathologic lesion that has been associated with hypovitaminosis A in amphibians is squamous metaplasia of the lingual and oral mucosa. In an attempt to further characterize the range of lesions that may be associated ...
Zhong Minghao M *Department of Pathology, Westchester Medical Center/New York Medical College, Valhalla ‡Mount Sinai Medical Center, New York, NY §Department of Pathology, Northwestern University, Chicago, IL †Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, - - 2014
Nested variant of urothelial carcinoma (NVUC) is an uncommon variant with minimally atypical cytology, which may overlap with benign urothelial lesions such as von Brunn nests, cystitis cystica, cystitis glandularis, and nephrogenic adenoma. Because of the tumor's deceptively bland appearance, these cancers can potentially be misdiagnosed as benign lesions, leading ...
de Carvalhosa Artur Aburad AA Department of Oral Sciences, University of Cuiabá, MT, Brazil; Cancer Hospital, Cuiabá, Mato Grosso, Brazil. Electronic address: - - 2014
Lesions of nonendodontic origin may mimic apical periodontitis. Central giant cell lesions (CGCLs) are aggressive or nonaggressive benign idiopathic intraosseous lesions of the jaw. This report describes a case of a CGCL in the periapical region of teeth #21-#26 of a 17-year-old female who sought orthodontic care because of a ...
Costa Neto H H Department of Dentistry, Federal University of Rio Grande do Norte, Natal, - - 2014
To evaluate and compare the immunoexpression of tryptase in samples of periapical granulomas (PGs) and radicular cysts (RCs) correlating it with the type of lesion, localization, intensity of the inflammatory infiltrate and thickness of the cystic epithelial lining, in order to gain insight into the phlogistic role of these cells ...
Mallmann Michael R MR Department of Obstetrics and Prenatal Medicine, University of Bonn, Bonn, - - 2014
The authors present the case of a prenatally diagnosed covered cloacal exstrophy in a female fetus and potential differential diagnoses within the exstrophy-epispadias complex. While on prenatal ultrasound, low-set umbilicus, omphalocele, diastasis of the pubic rami, split vulva and left-sided renal agenesis were suggestive of classic cloacal exstrophy, the presence ...
Al-Salhi Waleed - - 2014
Background:Pemphigoid nodularis is a rare clinical variant of bullous pemphigoid characterized by overlapping clinical features of both prurigo nodularis lesions and bullous pemphigoid blisters. The condition appears to be more common in females and is often resistant to treatment.Objective:To raise awareness of this rare variant of bullous pemphigoid.Methods:Case report.Results and ...
Robinson Stephanie M SM Department of Geriatric Medicine, Galway University Hospital, Galway, - - 2014
Studies suggest that most people support screening for and disclosure of dementia, but it is not clear whether respondents have reflected on the benefits and risks of diagnosis. In this study, preferences, rated on a 7-point Likert scale, for diagnosis, disclosure and screening for AD were measured before and after ...
Ballester Sánchez R R Servicio de Dermatología, Hospital Universitario y Politécnico La Fe, Valencia, España. Electronic address: - - 2014
Mucosal melanoma is a rare melanoma subtype that differs from the cutaneous form of the tumor in its biology, clinical manifestations, and management. Diagnosis is usually late due to a lack of early or specific signs and the location of lesions in areas that are difficult to access on physical ...
Razmpoosh Maryam M From the Department of - - 2014
To study and compare the effectiveness of p16(INK4a) staining and specific human papillomavirus (HPV) subtypes as a prognostic marker in cervical intraepithelial neoplasia grade 1 (CIN1; low-grade squamous intraepithelial lesions). Sixty-four cervical samples diagnosed as CIN1 and stained with p16(INK4a), with HPV status assessed by polymerase chain reaction-direct sequencing. Of ...
Roda Dominic J - - 2014
Merkel cell carcinoma is a rare, often fatal, neuroendocrine cutaneous malignancy with a highly variable clinical presentation. Due to the rapid progression of the disease, early detection and treatment is vital to survival. Here, we report the case of a 45-year-old woman whose podiatrist noticed an unusual lesion on her ...
Hikawa Renato Shintani RS Universidade Federal de São Paulo, São Paulo, SP, - - 2014
Melanoma is a malignant melanocytic neoplasm with high mortality rate, and steadily and universally increasing incidence rates. Polypoid melanoma is considered an exophytic variant of the nodular subtype. The incidence of polypoid melanoma is extremely variable, most likely because of the different criteria used for its characterization. We presented a ...
Calisir Cuneyt C Department of Radiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey, - - 2014
Fibro-osseous pseudotumor (FOPT) is a rare and benign ossifying lesion. Described as the superficial variant of myositis ossificans (MO), this rare entity mostly occurs in the subcutaneous tissues of the digits. The FOPT clinicopathological features may mimic a variety of benign and malignant soft tissue lesions, and the diagnosis can ...
Roda Dominic J DJ a Roger Williams Medical Center, - - 2014
Abstract Merkel Cell Carcinoma is a rare, often fatal, neuroendocrine cutaneous malignancy with a highly variable clinical presentation. Due to the rapid progression of the disease, early detection and treatment is vital in survival rates. Here, we report on the case of a 45 year old female whose podiatrist noticed ...
Alvarez-Larrán Alberto A Department of Haematology, Hospital del Mar, IMIM, Universitat Autònoma de Barcelona, Barcelona, - - 2014
Bone marrow histology is included in the diagnostic criteria of myeloproliferative neoplasms (MPNs). However, some concerns have emerged about its reproducibility. To evaluate the diagnostic accuracy of histology and to assess its correlation with presence of mutations and clinical outcomes, two pathologists reviewed the bone marrow biopsies corresponding to 211 ...
Torres Diogo D University of Louisville, Louisville, KY, USA - - 2014
Extrauterine adenomyomas are extremely rare benign tumors of smooth muscles, endometrial glands, and endometrial stroma. Ectopic endometrial glands can undergo malignant change. The ovary is the most common site of malignant change in endometriosis. Cancer arising in extraovarian endometriosis is a rare event with limited cases in the literature. To ...
Lacruz Goretti G Melanoma Unit, Dermatology Department, Hospital Clínic of Barcelona, IDIBAPS, Barcelona, - - 2014
Background: Acral melanoma (AM) is still one of the most poorly studied melanomas. It generally presents beyond the fifth decade of life and usually is a BRAF wild-type melanoma. Objective: To report the first cases of multiple primary AM in Caucasians. Methods: Clinical, dermoscopic, pathological and molecular profiles. Results: A ...
Pleyer C C Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, - - 2014
There is symptom overlap between gastro-esophageal reflux disease (GERD) and functional dyspepsia (FD). We aimed to test the hypothesis that FD cases are now more likely mislabeled as GERD. In subjects from Olmsted County, MN seen at Mayo Clinic: (i) Investigation of GERD and FD diagnosis rates between 1985 and ...
Floriano Isabela I Department of Pediatric Dentistry, School of Dentistry, Universidade de São Paulo, São Paulo, - - 2014
We assessed association between active caries lesions assessed by two different criteria and clinical features of these caries lesions. Three examiners examined forty-nine 3-12-year-old children: one examiner used the Nyvad criteria, another examiner used the International Caries Detection and Assessment Criteria with an additional criteria - Lesion Activity Assessment (ICDAS+LAA) ...
Ton Nu Tuyet Nhung TN Department of Pathology, McGill University Health Center and McGill University, Montreal, Quebec, - - 2014
The terminology used in reporting urine cytology lacks uniformity and the significance of the "atypical" and "suspicious" categories is still not well established. This results in variable clinical follow-up and management of those cases. The authors sought to investigate the prognostic value of a diagnosis of "suspicious for high-grade urothelial ...
Cabay Robert J RJ From the Department of Pathology, College of Medicine, and the Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, University of Illinois Hospital & Health Sciences System, Chicago, - - 2014
Context.- Some dental abnormalities have environmental causes. Other odontogenic alterations are idiopathic and may have hereditary etiologies. Investigations of these conditions are ongoing. Objective.- -To provide a discussion of developmental odontogenic abnormalities and benign odontogenic overgrowths and neoplasms for which genetic alterations have been well demonstrated and well documented. Data ...
Wang Yen Tun YT *Division of Dermatology, Ronald Reagan UCLA Medical Center, Los Angeles, CA; and †Department of Pathology and Laboratory Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, - - 2014
: Although approximately 876,000 individuals in the United States currently have a diagnosis of melanoma, the Touton-like giant cell variant has been described only twice in the literature to date. In our case, a 70-year-old man with a history of sclerosing carcinoma on the scalp presented for evaluation of a ...
Smith Lauren A - - 2014
Rosacea fulminans, previously known as pyoderma faciale, is a rare disease occurring almost exclusively in young women characterized by the sudden eruption of coalescing papules and pustules, and large cystic nodules limited to the face. Patients generally respond well to standard therapy consisting of systemic isotretinoin in combination with topical ...
Alves João Vítor Pina JV Hospital Garcia de Orta, Almada, - - 2014
Several variants of dermatofibroma have been described. They are essentially distinguished by their clinical and histopathological features. To review the mainfeaturesof these variants, a retrospective study of skin biopsies and tissue excisions of dermatofibromasperformed in the dermatology and venereology service at the Hospital Garcia de Orta between May 2007 and ...
Shah Azhar Ali AA Department of Surgery, Ghulam Muhammad Mahar Medical College, - - 2014
Endometriosis is the condition where endometrium gets implanted and flourishes outside the uterine cavity, most commonly in ovary and on the peritoneum which lines the abdominal cavity and viscera. Endometrial cells in areas outside the uterus are influenced by hormonal changes and respond in a way similar to the endometrium ...
Ariyawardana Anura A School of Medicine and Dentistry, James Cook University, McGregor Road, Smithfield, QLD 4878, Australia, Tel: +647-4232-1248; e-mail: - - 2014
Oral mucosal lesions are a common occurrence and very often dentists are called upon to see such patients. Among many causes trauma is one of the leading for oral mucosal diseases. Oral traumatic lesions are diverse in which some present as acute lesions while the majority are chronic lesions. Clinical ...
Jindal Chhavi C Reader, Department of Oral & Maxillofacial Pathology, National Dental College & Hospital , Derabassi, Mohali, Punjab, India - - 2014
Adenomatoid odontogenic tumour is an uncommon, benign, hamartomatous lesion that commonly affects the anterior maxilla and has two radiographic variants, follicular and extrafollicular where the former is more common than the latter. Here, we report a case of 15-year-old female with midline swelling of the mandible. Radiographically, impacted right permanent ...
Milenović Aleksandar - - 2014
We present case of oral and skin anaplastic T-cell lymphoma in a 68-year-old woman. The patient presented with extensive ulcerations and necrotic tissue on the left mandibular gingiva. Orthopantomogram finding showed extensive necrolytic lesions of the adjacent mandible. Biopsy finding of oral lesions and subsequently of the skin confirmed the ...
Frank Paul N PN Section of Endocrine Surgery, Department of Surgery, David Geffen School of Medicine, University of California, Los - - 2014
IMPORTANCE Benign granulomatous disease may mimic malignant disease in the evaluation of mediastinal or pulmonary lesions. However, histoplasmosis as a cause of cervical lymphadenopathy is relatively rare. We report the first case of Histoplasma infection mimicking malignant adenopathy discovered during diagnostic thyroid lobectomy. OBSERVATIONS A 2.5-cm, calcified, right paratracheal lymph ...
Romanoff Anya M AM Department of Surgery, Dubin Breast Center, Mount Sinai Medical Center, New York, NY, USA, - - 2014
Breast pathology is a challenging field, and previous work has shown discrepancies in diagnoses, even among experts. We set out to determine whether mandatory pathology review changes the diagnosis or surgical management of breast disease. Cases were referred for pathology review after patients presented for surgical opinion to the Dubin ...
Le Mercier Marie M Department of Pathology, Erasme University Hospital, Université Libre de Bruxelles (ULB), Brussels, - - 2014
The assessment of thyroid nodules is a common clinical challenge. Fine-needle aspiration (FNA) is the standard preoperative tool for thyroid nodule diagnosis. However, up to 30% of the samples are classified as indeterminate. This often leads to unnecessary surgeries. In this study, we evaluated the added value of next-generation sequencing ...
Gaeti João Guilherme L N JG Laboratory of Veterinary Pathology, Federal University of Mato Grosso (UFMT), Av. Fernando Corrêa da Costa 2367, Cuiabá, Mato Grosso, CEP 78069-900, - - 2014
Ureaplasma diversum has been associated with various reproductive problems in cattle that include granular vulvovaginitis, weak calves, and abortion. This study was conducted in a beef herd situated in the Middle-West region of Brazil, and the objectives were to verify the presence of U. diversum and to elucidate its possible ...
Kalra Ankur A Advanced Heart Failure and Cardiac Transplantation, Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, MN, USA, - - 2014
Endomyocardial biopsy (EMB) is central to the diagnosis of giant-cell myocarditis (GCM) and planning further management. There is, however, no guideline-directed recommendation on re-biopsy or left ventricular EMB in a suspected case of acute, fulminant myocarditis following an indeterminate first biopsy. This manuscript illustrates, with a case, the changing role ...
Beaudenon-Huibregtse Sylvie S Asuragen Inc., Austin, Texas, United States ; - - 2014
<b><i>Background:</b></i> Molecular testing for oncogenic gene mutations and chromosomal rearrangements plays a growing role in the optimal management of thyroid nodules, yet lacks standardized testing modalities and systematic validation data. Our objective was to assess the performance of molecular cytology on preoperative thyroid nodule fine needle aspirates (FNAs) across a ...
Kono Yoshiyasu Y Yoshiyasu Kono, Yasushi Yamasaki, Kazuhide Yamamoto, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, - - 2014
To investigate the usefulness of chromoendoscopy, using an acetic acid indigocarmine mixture (AIM), for gastric adenoma diagnosed by forceps biopsy. A total of 54 lesions in 45 patients diagnosed as gastric adenoma by forceps biopsy were prospectively enrolled in this study and treated by endoscopic submucosal dissection (ESD) between January ...
Burciu Roxana Gabriela RG Department of Neurology, University Clinic Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany, - - 2014
Studies of cerebellar patients employing modern lesion-symptom mapping techniques have provided valuable insights into the contribution of the cerebellum to motor adaptation. In patients with chronic focal lesions of the cerebellum, the process of adapting reaching movements to force field (FF) and visuomotor rotation (VM) perturbations relies on different anatomical ...
Mooi Wolter J WJ Department of Pathology, VU University Medical Center Amsterdam, Amsterdam, The - - 2014
On the basis of a critical review of published literature, it is concluded that there is as yet insufficient evidence to conclude that the melanocytic lesion, which is currently known as "lentiginous melanoma," is a full-fledged melanoma, with the capacity to metastasize to distant sites and to cause the demise ...
Argenziano Giuseppe G Skin Cancer Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio, Emilia, - - 2014
The development of new primary melanomas in patients treated with vemurafenib has been reported recently in a study by Perier-Muzet et al. The primary outcome of the study was to describe the dermoscopic changes that prompted excision of those melanomas. However, the crucial point raised by the study is the ...
Slade Austen D AD aDepartment of Pediatric Surgery, The University of Texas Medical School at Houston bDepartment of Pediatrics, Children's Cancer Hospital, The University of Texas M.D. Anderson Cancer Center cDepartment of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, - - 2014
To inform pediatricians of the challenges of detection of melanoma in children and adolescents as well as to instruct on proper biopsy technique of suspicious lesions. The incidence of melanoma in children and adolescents is on the rise with an average increase of 2% per year. Rates of change are ...
Bhushan Nvv Satya NS Professor, Department of Oral and Maxillofacial Surgery, GITAM Dental College and Hospital , Vishakhapatnam, India - - 2014
We are reporting a case of an ameloblastoma which arose in the wall of a dentigerous cyst. The clinical, radiographic and histological characteristics were similar to those of dentigerous cysts, as were seen on doing an incisional biopsy. Enucleation was done intraorally under local anaesthesia. Post-operative excisional biopsy revealed strands ...
Dewitt John M JM Division of Gastroenterology and Hepatology, Indiana University Medical Center, Indianapolis, Indiana, - - 2014
Background and study aims: Endoscopic ultrasound (EUS)-guided ethanol lavage with paclitaxel injection has been shown to be effective for the treatment of pancreatic cystic neoplasms; however, the evidence for effectiveness is based primarily on cyst resolution on imaging. The aim of this study was to evaluate changes in pancreatic cyst ...
Niebling Maarten G MG Melanoma Institute Australia, Sydney, NSW, - - 2014
Pathologists sometimes disagree on the diagnosis of melanoma or its histopathologic staging, which may have implications for treatment and follow-up. For this reason, melanoma patients referred to Melanoma Institute Australia (MIA) for further treatment routinely have their pathology slides reviewed by MIA pathologists. This study sought to determine whether diagnosis, ...
Wall James J aDivision of Pediatric Surgery, Lucile Packard Children's Hospital, Stanford University, Palo Alto, California bPediatric Pulmonary Division, Department of Pediatrics, Tufts University School of Medicine, Boston, Massachusetts, - - 2014
Congenital lung malformations (CLMs) vary in their clinical presentation and severity. Increases in prenatal diagnosis, observed regression of certain lesions, and prognostic uncertainty are driving an evolution in management. There has been an increase in the early diagnosis of these malformations, a change that is attributable to the routine use ...
Bouillet Laurence L National Reference Centre for Angioedema (CREAK), Internal medicine department, Grenoble University Hospital, BP 217 38043 Grenoble cedex 09 France, Unité Inserm 1036, CEA, Université de médecine Joseph-Fourier, Grenoble, - - 2014
The aetiologies of recurrent angioedema (AE) comprise the frequent histaminergic AE and the rare bradykinin-mediated AE. Diagnosis must be done carefully because they do not have the same treatment. Diagnosis strategy is clinical. The most specific symptoms for bradykinin AE are: isolated AE without wheals, long duration of the attack, ...
Xing Yanfen Y Department of Radiology, People's Hospital of LaiWu - - 2014
Recent studies have revealed a potential relationship between the presence of ground glass opacity (GGO) on regular computerized tomography(CT) and adenocarcinomas. To investigate features of pre-invasive lung adenocarcinoma lesions on thin-section computerized tomography (CT). We evaluated 59 cases of atypical adenomatous hyperplasia (AAH) and 35 cases of adenoma in situ ...
Halkud Rajshekar R Department of Head and Neck oncosurgery, KMIO, Bangalore, KA - - 2014
Multiple oculo-cutaneous malignancies are a common manifestation on sun-exposed facial areas in patients with Xeroderma pigmentosum (XP). Commonly seen are the basal cell carcinoma and the squamous cell carcinomas which manifest in the early first decade in contrast to fifth and sixth decade in the general population. XP manifests as ...
Nguyen T T Houston VA HSR&D Center of Excellence, Baylor College of Medicine, Houston, Texas, USA; Department of Medicine, Baylor College of Medicine, Houston, Texas, - - 2014
Few studies have examined the temporal trends of length in newly diagnosed Barrett's esophagus (BE) and arrived at conflicting results. The aim of this study was to identify whether there has been a change over time in the length of BE at the time of diagnosis. This is a retrospective, ...
Kim J S JS Department of Dermatology, Hanyang University Guri Hospital, Guri, - - 2014
Lipomembranous changes are distinctive histopathological findings, which include the presence of cystic cavities lined by crenulated, hyaline membranes in adipose tissue. It is likely that ischaemia is fundamental to the development of these lesions, and that lipomembranes are formed from the products of degenerating fat cell membranes by some unknown ...
Sinnya Sudipta S Dermatology Research Centre, School of Medicine, University of Queensland, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Queensland, - - 2014
We present a case of verruciform xanthoma ((VX) of the penis in an elderly man in whom an asymptomatic papule on his foreskin was noted during a routine clinical examination. VX is a rare, benign condition with a predilection for the oral cavity and clinically presents as isolated, painless mucosal ...
Franco Joanna Pimenta de Araujo JP State of Rio de Janeiro Federal University, Rio de Janeiro, RJ, - - 2014
Dermatofibrosarcoma protuberans is a fibrohistiocytic tumor of intermediate malignancy with aggressive localized growth, high recurrence rate, but low metastatic potential. It appears as a hardened plaque, with slow growth, upon which the development of nodules occurs. It predominates in the trunk and is unusual in acral locations. Histopathology reveals spindle ...
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