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Westphal Manfred M Department of Neurological Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany, - - 2015
The pineal region is a complex anatomical compartment, harbouring the pineal gland surrounded by the quadrigeminal plate and the confluents of the internal cerebral veins to form the vein of Galen. The complexity of lesions in that region, however, goes far beyond the pineal parenchyma proper. Originating in the pineal ...
Cundell David D Department of Cellular Pathology, Southmead Hospital, Bristol, - - 2014
We present a case of borderline serous tumour of the testis with both genotypic and phenotypic features in common with low grade serous ovarian neoplasia. A 65 year-old man presented with a testicular mass, confirmed to be tumour on ultrasound scan. A resulting orchidectomy specimen measured 70 x 40 x ...
Zheng Yangming - - 2014
Congenital tuberculosis (TB) is a rare disease with a high mortality rate, and is difficult to diagnose. Here we present a case of congenital TB detected by the T-SPOT.TB assay in a male infant after in vitro fertilization. He ultimately survived after anti-TB therapy despite a delayed diagnosis, and underwent ...
Uhlenhake Elizabeth E EE University of Arkansas for Medical Sciences Department of Pathology, Little Rock, - - 2014
A 26-year-old female presented with a 7 mm irritated pink-red papule on the left posterior shoulder. A shave biopsy revealed a dermal proliferation of epithelioid cells arranged in small nests with central lumen-like structures resembling glands set in a densely sclerotic stroma. S100 and MART-1 immunohistochemical positivity confirmed a dermal melanocytic ...
Lester Elizabeth B EB University of Vermont Department of Dermatology, Burlington, - - 2014
Evolving lesions of lichen sclerosus (LS) pose a diagnostic challenge due to an absence of classic findings of epidermal atrophy, dermal sclerosis, a band-like lymphocytic infiltrate, and the presence of eosinophils. Retrospective specimens of LS were reviewed. Demographic information, biopsy verusus excision, and the following histopatological characteristics were noted: presence ...
Fox Karen A KA 1  Colorado Parks and Wildlife, Wildlife Health Research Center, 317 West Prospect Road, Fort Collins, Colorado 80525, - - 2014
Abstract Antler abnormalities of deer and other cervids often result from testicular lesions and decreased levels of testosterone, inhibiting normal cycles of antler growth. Affected males have antlers with retained velvet, numerous short, misshapen points ("cactus bucks"), and failure to shed these abnormal antlers annually. In Colorado, we observed a ...
Abdou Ag A Asmaa Gaber Abdou, Faculty of Medicine, Pathology Department, Maxeem street, 002 Shebein Elkom, Egypt, e-mail: - - 2014
Sebaceous trichofolliculoma is considered as hamartomatous lesion with follicular differentiation. In this study, we demonstrated a classic histopathologic picture of sebaceous trichofolliculoma in a 65-year-old male presented with large sized right cheek swelling.
Aslzare Mohammad M Mashhad University of Medical Sciences, Islamic Republic of - - 2014
Inflammatory myofibroblastic tumour (IMT) is a rare spindle tumour that mimics malignant processes. It can affect any part of the body, but rarely occurs in the genitourinary tract. We report a case of urethral IMT in a 31-year-old female. The diagnosis was established by histological findings and confirmed by immunohistochemical ...
Gopal Dhruv D Department of Skin and STD, Safdurjung Hospital and Vardhman Mahavir Medical College, New Delhi, - - 2014
A 50-day-old female child presented with asymptomatic skin colored raised lesion on the dorsal aspect of the left wrist since the age of 10 days. The diagnosis of cutaneous mastocytoma was made based upon clinical and histopathological features.
Dillon Jessica R JR Department of General Dentistry, 1st Dental Battalion Naval Dental Center, Building 22190, Camp Pendleton, CA, 92055, USA, - - 2014
A case of a dermoid cyst of the floor of mouth affecting a 19 years old male will be discussed. The macroscopic and histologic findings used for diagnosis will be covered. The typical features of this type of cyst will also be reviewed including radiographic and histologic findings. Discussion will include ...
Manuguerra Roberta R Unit of Pathology, Department of Biomedical, Biotechnological, and Translational Sciences - - 2014
Synovial sarcoma (SS) is a rare mesenchymal malignant neoplasm, which affects the head and neck region in only 5% of cases. In this scenario, the parotid gland is an exceedingly uncommon anatomical site.(1) A 37-year-old man was referred to our hospital because of recurrence of a slow-growing right parotid mass. ...
Pandiar Deepak D Senior Resident, Department of Oral Pathology, GDC Calicut , Kerala, India - - 2014
Benign osteoblastoma is a rare bone tumour characterized histologically by production of woven bone spicules, which are bordered by prominent osteoblasts. It mainly affects male teenagers and young adults. A case of benign osteoblastoma of maxilla in a nineteen years old male is reported here. Also, histological comparison is made ...
Kanade Umesh Sidheshwar US Assistant Professor, Department of Pathology, Government Medical College and Hospital Latur, India - - 2014
Sertoli-Leydig cell tumours (SLCTs) are rare sex cord stromal neoplasms of ovary accounting for less than 0.5% of all ovarian tumours. These are found in women of all age groups (2-75 y), but are most common in reproductive age group with an average age of 25 y. Mostly these are ...
Pintus Eliana E 1  Department of Pathology and Veterinary Clinic, University of Sassari, Via Vienna 2, 07100 Sassari, - - 2014
Abstract We used fine needle aspiration cytology (FNAC) to diagnose Sertoli cell-only pattern and hypospermatogenesis in an Iberian red deer (Cervus elaphus hispanicus). Cytologic diagnosis was confirmed by histology and epididymal sperm analysis. We conclude that FNAC can be an important diagnostic tool in testicular diseases of wildlife.
Nistal Manuel M Department of Anatomy, Histology and Neuroscience, Autonomous, University of Madrid, Madrid, - - 2014
To characterize the exceptional finding of multiple cysts in the parietal layer of the tunica vaginalis of the testis in three patients. We report three cases of a new entity for which we propose the term florid cystic mullerianosis of the testis. Macroscopically it consists of a thickened tunica vaginalis ...
Crisan Diana D Department of Histology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, - - 2014
Dermatofibroma (benign fibrous histiocytoma) represents one of the most common skin tumors. We present the case of a 52 year old female patient with a highly pigmented nodular lesion, localized on the right thigh. Dermoscopy completed the clinical diagnosis, but could not exclude a malignant tumour . Ultrasound examination (Dermascan ...
Lee Byung-Do BD Department of Oral and Maxillofacial Radiology and Wonkwang Dental Research Institute, College of Dentistry, Wonkwang University, Iksan, - - 2014
Glandular odontogenic cyst (GOC) is a rare, potentially aggressive jaw lesion. The common radiographic features include a well-defined radiolucency with distinct borders, presenting a uni- or multilocular appearance. A cystic lesion in the posterior mandible of a 78-year-old female was incidentally found. Radiographs showed a unilocular lesion with a scalloped ...
Lee Seung Y - - 2014
Unilateral laparoscopic ovariectomy was attempted in a red fox (Vulpes vulpes) with an ovarian cyst through single portal access. The ovarian cyst was resistant to conservative therapy using gonadotropin-releasing hormone. A 10-mm laparoscope with an operating channel was introduced into the abdomen via a 12-mm umbilical portal. The left ovary ...
Shashidara R R Department of Oral and Maxillofacial Pathology, Coorg Institute of Dental Sciences, Virajpet, Karnataka, - - 2014
Lymphomas are neoplastic diseases of lymph nodes. Lymphoma of the salivary gland is rare accounting for less than 5% of lymphomas overall. Furthermore, lymphomas arising in the submandibular gland are reported to comprise 916% of all salivary gland lymphomas. Among lymphomas originating from salivary glands, the ratio of follicular lymphoma ...
Mardekian Stacey K SK Department of Pathology, Thomas Jefferson University, 285 Main Building, 132 S. 10th St, Philadelphia, PA, 19107, USA, - - 2014
A case of osteosarcoma developing from fibrous dysplasia of the sphenoid bone in a 59-year-old female will be discussed. The characteristic radiologic and histologic features of the entity will be described.
Torres Crg - - 2014
SUMMARY Developmental defects involving color alteration of enamel frequently compromise the esthetic appearance of the tooth. The resin infiltration technique represents an alternative treatment for color masking of these lesions and uniformization of tooth color. This technique is considered relatively simple and microinvasive, since only a minimal portion of enamel ...
Chaudhary Vikas V Department of Veterinary Gynecology and Obstetrics College of Veterinary and Animal Sciences, Rajasthan University of Veterinary and Animal Sciences, Bikaner, Rajasthan 334001, - - 2014
Abattoir derived buffalo genitalia (n=98) were evaluated for uterine pathology employing palpable, ultrasonographic and hysteroscopic visualization. A high proportion (45.92%) of genitalia evidenced uterine pathology including endometritis (14.29%), pyometra (7.14%), hemorrhages in the endometrium (14.29%) and mucometra (6.12%). The sensitivity and specificity of hysteroscopy was 100% for endometritis and hemorrhages ...
Bergmann Frank F Institute of Pathology, University of Heidelberg, Heidelberg D-69120, - - 2014
The biology of pancreatic acinar cell cystadenomas has not been clearly defined. However, a non-neoplastic process, caused by a cell differentiation failure leading to a cystic transformation, has been discussed, as well as a benign neoplastic lesion. Pancreatic acinar cell cystadenomas usually consist of thin-walled unilocular or multilocular cysts, and ...
Jain Prabha P Department of Radiology, Middlemore Hospital, Manukau, New Zealand (P.J.); and Department of Surgery, University of Auckland, Auckland, New Zealand (R.J.). - - 2014
Plunging ranulas have been shown to have a common trio of mylohyoid defects, sublingual gland herniation, and submandibular space fluid collections. The herniated sublingual gland may be susceptible to subclinical trauma. The purpose of this study was to investigate the frequency of occurrence of various types of active sublingual gland ...
Droy-Dupré Laure L CHU Nantes, Service d'Anatomie et Cytologie Pathologiques, Nantes, - - 2014
Villous tumours of the rectosigmoid are historically defined as broad-based lesions associated with secretory diarrhoea. This study aimed to perform a reappraisal of these tumours, on the basis of newly introduced histological, immunohistochemical and molecular parameters. For this study, 22 villous tumours, diagnosed by endoscopic criteria (19 Paris 0-IIa, three ...
Hannan Abdul - - 2014
Mature cystic teratoma (MCT) is a common ovarian neoplasm in young females. A secondary malignant transformation occurs rarely in cystic teratomas at an older age. These secondary malignant neoplasms most commonly are squamous cell carcinomas (SCCs). Various mechanisms are reported, but the exact aetiology is unknown. We report three cases ...
Sahora Klaus K Department of Surgery, Massachusetts General Hospital, Boston, MA; Department of Surgery, Harvard Medical School, Boston, - - 2014
The malignant potential of intraductal mucinous neoplasm of the pancreas (IPMN) is associated closely with main pancreatic duct (MPD) involvement. Because mixed-type IPMN is thought to have the same malignant potential as that of main-duct (MD)-IPMN, resection is recommended; however, the biological nature of mixed-type IPMN with only minimal involvement ...
Alaeddini Mojgan M Dental Research Centre, Tehran University of Medical Sciences, Tehran, - - 2014
In addition to ultraviolet radiation exposure, various molecular markers may differ between oral mucosal and cutaneous head and neck melanomas and lead to variations in their biologic behavior and prognosis. The aim of this study was to compare four such markers, namely microphthalmia transcription factor (MITF), P75, P53, and Ki-67 ...
Yoshida Rui - - 2014
Epidermodysplasia verruciformis is a rare genodermatosis characterized by a unique susceptibility to cutaneous human papillomaviruses infection. Most patients show autosomal recessive patterns of inheritance. We report a case of two sisters with clinically epidermodysplasia verruciformis specific lesions on the face, neck, trunk, and extremities. PCR analysis indicated the presence of ...
Wang Yiying - - 2014
BackgroundSerous tubal intraepithelial carcinoma (STIC) and the p53 signature in tubal mucosa have been supported to be precursor lesions in high-grade serous carcinoma (HGSC) of the fallopian tube, ovary, and peritoneum. It remains critical to find biomarkers for precursor lesions in order to detect HGSCs efficiently. IMP3 is an oncoprotein ...
Yamane L S LS Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, - - 2014
Colorectal cancer (CRC) is one of the most frequent cancers worldwide. Adenoma is the main precursor lesion and, recently, the serrated polyps were described as a group of colorectal lesions with malignant potential. The morphologic and biologic characterizations of serrated polyps remain limited. The aim of the present study was ...
Preti Mario M Gynecological Oncologist, Department of Obstetrics and Gynecology, University of Turin, Via Ventimiglia 3, Turin, Italy. Electronic address: - - 2014
Vulvar intraepithelial neoplasia (VIN) is a high-grade intraepithelial squamous lesion and precursor of invasive squamous cell carcinoma (SCC). The 2004 International Society for the Study of Vulvovaginal Disease (ISSVD) classification distinguished two types of VIN: usual type (human papillomavirus (HPV)-related) and differentiated type (not HPV-related). The incidence of usual-type VIN ...
Singh Naveena N Departments of *Cellular Pathology ‡Gynecological Oncology, Barts Health NHS Trust, London, United Kingdom †Department of Pathology, Sunnybrook Health Sciences Centre, Toronto, ON §Department of Pathology ‚ą•Division of Gynecological Oncology, Vancouver General Hospital, Vancouver, BC, - - 2014
The pathogenesis of vulvar squamous cell carcinoma follows 1 of 2 distinct pathways. A precursor lesion in the human papilloma virus-independent pathway, differentiated vulvar intraepithelial neoplasia (dVIN), was only recently characterized in detail and is infrequently diagnosed without an associated component of invasive carcinoma. Aberrant p53 immunostaining is frequently seen ...
Kim Eun Soo ES Department of Radiology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of - - 2014
Malignant transformation or recurrence of intracranial mature teratoma is an extremely rare occurrence, compared to the usual ovarian counterpart. Previously, yolk sac tumor elements have been considered to be selective progenitors of enteric-type adenocarcinoma arising from intracranial germ cell tumors. However, the present case demonstrates the occurrence of enteric-type adenocarcinoma ...
Watanabe Gen G Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, - - 2014
Although intestinal-type epithelium in Barrett's oesophagus has been traditionally recognised as having a distinct malignant potential, whether this also holds true for cardiac-type epithelium remains controversial. The aim of this study was to identify highly associated type of epithelium with Barrett's tumour. We analysed tumours and the corresponding background mucosa ...
Dos Santos Vitorino Modesto VM Catholic University Medical Course, Brasília-DF, Brazil . AND Department of Internal Medicine, Armed Forces Hospital, Brasília-DF, Brazil. - - 2014
Pachyonychia congenital (PC) is a rare autosomal dominant genodermatosis characterized hyperkeratosis affecting the nails and palmoplantar areas, oral leukokeratosis, and cystic lesions. A 39-year-old woman with PC type 1 (Jadassohn-Lewandowsky syndrome) and B-cell lymphoma is described. No similar disorders or parental consanguinity were found in her family. Typical features of ...
Mukherjee Samipa S Departments of Dermatology, Venereology and Leprosy, Christian Medical College and Hospital, Vellore, Tamil Nadu, - - 2014
Angioma serpiginosum is a cutaneous vascular nevoid disorder that presents as red, nonblanchable and grouped macules distributed in a serpiginous pattern and resembles purpura. It usually begins in childhood and commonly affects the lower limbs and the buttocks. Late onset of the lesions is unusual. We report a 46-year-old female ...
Oranusi Chidi-Kingsley CK Department of Surgery, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, - - 2014
Testicular biopsy is an acknowledged method of examination of the testes for diagnostic and therapeutic purposes. We describe the pattern of testicular histologies in our environment. We carried out a retrospective review of testicular histology results from the Pathology Department of Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, over a ...
Pandey Praveen K PK Department of Urology, Institute of Post-Graduate Medical Education and Research, Kolkata, - - 2014
Primary malignant melanoma of urethra is an extremely rare entity. It has very poor prognosis. A 62-year-old post-menopausal female presented with complaints of voiding difficulty and a mass projecting from external urethral meatus. External genital examination revealed a growth arising from urethral meatus with blood-stained discharge from its surface. Biopsy ...
Neri Iria I Division of Dermatology, Department of Specialized, Clinical and Experimental Medicine, University of Bologna, Bologna, - - 2014
Differential diagnosis between congenital Volkmann ischemic contracture (CVIC) and unilateral aplasia cutis congenita (ACC) type VII of the forearm presents a clinical challenge. Both diseases share the same clinical presentation characterized by a stellate ulceration over the upper extremities and reported association with neuromuscular defects, but the diagnostic criteria to ...
Eustace K K Department of Dermatology, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland, - - 2014
Lichen planus is an inflammatory mucocutaneous disorder, often idiopathic. It is postulated that the characteristic skin lesions arise from a T cell mediated autoimmune response against basal keratinocytes. Oral mucosal involvement can occur in up to 70 % of cases of cutaneous disease however, oesphageal involvement is rare. We report the ...
Meena Manju M Oculoplastic Unit, Department of Ophthalmology, Sydney Hospital and Sydney Eye Hospital , Macquarie Street, Sydney, NSW , Australia - - 2014
Abstract Purpose: To report an unusual presentation of a case of Lymphomatoid papulosis(LyP) in a young girl. Material and Methods: A 14-year-old female presented with a history of swelling of the left upper eyelid of two weeks duration. There was a history of trivial trauma prior to the swelling. The ...
Grey A A Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, - - 2014
Vemurafenib is a tyrosine kinase inhibitor of BRAF that prolongs survival in patients with BRAF V600-mutant metastatic melanoma. Secondary cutaneous malignancies are a well-documented toxicity of vemurafenib, thought to be mediated by enhanced ERK signalling in BRAF wild-type, RAS-mutant cells. Vemurafenib could also promote growth of non-cutaneous secondary malignancies by ...
Koo So-My SM Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, - - 2014
Malignant mesothelioma (MM) is the aggressive tumor of serosal surfaces. There are crude pathogenetic results regarding the biology of MM. Coordinated upregulations of p53 gene expression are shown in malignancies. We believed that there are changes in the p53 expression with transformation from reactive hyperplasia to MM. A 65-year-old male ...
Abid N - - 2014
Uterine tumours resembling ovarian sex-cord tumours (UTROSCT) are very rare, benign uterine tumours, composed solely of sex cord elements. These tumours have a polyphenotypic immunophentype that favours a derivation from uterine mesenchymal stem cells. A 43-year-old female presented with recurrent vaginal bleeding. On hysteroscopy, she had multiple endometrial and cervical ...
Huff Wei X WX Department of Neurological - - 2014
Von Hippel-Lindau disease (VHLD) is characterized by a spectrum of benign and malignant tumors in the CNS and visceral organs. Rathke's cleft cysts are benign, nonneoplastic sellar lesions that are often asymptomatic. The authors report the case of twin sisters with VHLD Type 2C with radiographically similar sellar lesions. One ...
Nouraei S A Reza SA The National Centre for Airway Reconstruction, Department of ENT Surgery, Charing Cross Hospital , London W6 8RF , - - 2014
We present a system for classification of bilateral vocal fold mobility impairment. Type 1 obstructions are caused by bilateral laryngeal denervation, most commonly due to bilateral recurrent laryngeal nerve palsy. Type 2 obstructions are caused by crico-arytenoid joint ankylosis. Type 3 obstructions are due to inter-arytenoid granulation tissue. Type 4 ...
Bosse Kristopher R KR Division of Oncology, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, - - 2014
Malignant rhabdoid tumors (MRTs) are rare pediatric malignancies characterized by clinically aggressive lesions that typically show loss of SMARCB1 expression. We herein describe a case of a malignant rhabdoid tumor of the bladder in a 14-year-old male with an autism spectrum disorder and a de novo 3 Mb germline deletion ...
Aissa Khaoula K 1Faculté de médecine de Tunis, Université Tunis Elmanar. Hôpital Mohamed Tlatli de Nabeul, pediatrics, Nabeul, - - 2014
We have reported the first Tunisian case of triosephosphate isomerase (TPI) deficiency in a 2-year-old girl. She was the first child of a nonconsanguineous couple. The disease included a neonatal onset of chronic hemolytic anemia, recurrent low-respiratory infections then progressive neurological involvement. The diagnosis was made after her death from ...
Rekhi Bharat B Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, - - 2014
Papillary proliferations of the endometrium, without atypia have been uncommonly documented, including on cytology specimens. Herein, we present an uncommon case of a 55-year-old obese lady, on antihypertensive medications, who presented with history of irregular perimenopausal bleeding. A year ago, she was diagnosed with simple cystic hyperplasia on dilation and ...
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