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di Pietro Massimiliano M Medical Research Council, Cancer Unit, , University of Cambridge, Cambridge, - - 2014
Endoscopic surveillance for Barrett's oesophagus (BO) is limited by sampling error and the subjectivity of diagnosing dysplasia. We aimed to compare a biomarker panel on minimal biopsies directed by autofluorescence imaging (AFI) with the standard surveillance protocol to derive an objective tool for dysplasia assessment. We performed a cross-sectional prospective ...
Aydogdu Koray K Department of Thoracic Surgery, Atatürk Chest Diseases and Thoracic Surgery Research and Training Hospital, Ankara, - - 2014
Bronchogenic cysts are congenital malformations thought to originate from the primitive ventral foregut, and they are the most common type of mediastinal cystic lesion. The clinical presentation of a bronchogenic cyst is variable, from respiratory distress at birth to late appearance of symptoms. Most bronchogenic cysts originate in the mediastinum, ...
Gumaste Priyanka P *Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ; †Department of Dermatology, Dermatology Cosmetic and Laser Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ‡Department of Medicine-Division of Dermatology, UC San Diego, San Diego, CA; §Department of Dermatology, UC Irvine, Irvine, CA; ¶RBGB Dermatology, Santa Ana, CA; and ‖Laguna Pathology Medical Group, Laguna Beach, - - 2014
: Basaloid follicular hamartoma (BFH) is a rare, generally benign lesion of importance because of its clinical and histopathological similarity to infundibulocystic basal cell carcinoma. Autosomal dominant generalized BFH syndrome is 1 of the 5 clinical forms of BFH that has been described in the literature. We report a case ...
Horn Lars-Christian LC Division of Breast, Gynecologic & Perinatal Pathology, Institute of Pathology, University of Leipzig, Leipzig (L.-C.H.) Department of Obstetrics and Gynecology, Martin-Luther-University, Halle/Saale (U.K.B., H.-G.S, I.K.), - - 2014
The occurrence of ectopic intestinal/enteric-type epithelium at the vulva is a rare entity sometimes mimicking intraepithelial neoplasia or malignant disease. Here, we report a case of an 82-yr-old woman with a long-standing (10 yr) white papillary lesion with some reddish areas at her left labium, extending into the vaginal introitus. ...
Rodriguez-Gonzalez Marta M Pathology Department. University Hospital of Salamanca, Salamanca, Spain. - - 2014
Solitary pleuro-pulmonary fibrous tumours are relatively uncommon neoplasms that are difficult to manage therapeutically and which, cytogenetically, have been poorly studied. The aim of the present work was to analyse the characteristics of a series of consecutive operated solitary pleural fibrous tumours in an attempt to discover a malignant pattern ...
Tsai Jia-Huei JH 1] Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan [2] Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei, - - 2014
Traditional serrated adenoma is one type of colorectal serrated neoplasm and a precursor of colorectal cancer. We evaluated the pathologic and molecular features of 60 traditional serrated adenomas with cytologic dysplasia and/or invasive carcinoma. On the basis of morphological features, 16 cases (27%) were categorized as traditional serrated adenoma with ...
Shahzad Rafia R Department of Radiology, INMOL Hospital, - - 2014
Neurofibromatosis type 1 (NF1) rarely affects the female genital system. Plexiform neurofibromas are congenital lesions that occur exclusively in patients with neurofibromatosis type I. The vulva is the most frequent genital organ to be affected, whereas vaginal, cervical, uterine, and ovarian neurofibromas have also been reported only rarely. We present ...
Ghalayani Parichehr P Department of Oral Medicine and Torabinejad Dental Research Center, Isfahan University of Medical Sciences, School of Dentistry, ISFAHAN, - - 2014
Focal epithelial hyperplasia or Heck's disease is an infrequent asymptomatic condition caused by human papillomavirus types 13 or 32 affecting the mucous membrane of the mouth and is commonly seen in young individuals. Firstly, it was described in Indians and Eskimos, but it exists in various populations. We present three ...
Avilés-Izquierdo J A JA Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain. Electronic address: - - 2014
Animal-type melanoma is a rare variant of malignant melanoma in humans. Although many patients develop locoregional and distant metastases, mortality is lower than in other types of melanoma. We present 3 cases of animal-type melanoma in elderly men and include a description of common clinical and dermoscopic features (homogeneous blue ...
Göppner Daniela D Department of Dermatology and Venereology, Otto-von-Guericke University, Leipziger Str. 44, DE-39120 Magdeburg, - - 2014
There is growing evidence that not only malign keratinocytic but also melanocytic tumours can arise during treatment with vemurafenib. During an on-going early access trial, 13 patients harbouring a BRAF-V600E mutation received vemurafenib (Zelboraf®) 960 mg twice daily to test the safety, tolerability, efficacy and response rate for advanced melanoma. ...
Habiba Umma U Department of Oral Pathology and Biology, Hokkaido University Graduate School of Dental Medicine, Kita-ku, Sapporo 060-8586, - - 2014
Oral verrucous carcinoma (OVC) is a low grade variant of oral squamous cell carcinoma, and oral verrucous hyperplasia (OVH) is a benign lesion without malignant features. However, pathologists are sometimes presented with borderline lesions and are indecisive as to diagnose them as benign or malignant. Thus, these lesions are tentatively ...
Carriel Ictor I Department of Histology (Tissue Engineering Group), University of Granada, Granada, Spain, Department of Basic Medical Sciences, Faculty of Medicine, Ghent University, Ghent, Belgium, and Pathology Unit, San Camilo Hospital, University of Valparaíso, San Felipe, Chile. - - 2014
Gallbladder duplication is a rare congenital anomaly, with an incidence of 1 in 3,800 autopsies. The correct diagnosis and treatment of this type of entity is important in clinical practice, because it may cause some clinical and surgical problems. In this report, we present the clinical case of a 28-year-old ...
Vilela Maria Helena Tavares - - 2014
Adequate management of phyllodes tumors of the breast (PTB) remains a challenge because of the difficulty in correctly establishing preoperative diagnosis. The aim of this study was to evaluate the usefulness of Ki-67, CD10, CD34, p53, CD117, and of the number of mast cells in the differential diagnosis of benign ...
Heard Melissa E ME Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR - - 2014
Endometriosis, a steroid hormone-dependent disease characterized by aberrant activation of estrogen receptor signaling and progesterone resistance, remains intractable due to the complexity of the pathways underlying its manifestation. We previously showed that eutopic endometria of women with endometriosis exhibit lower expression of Krüppel-like factor 9 (KLF9), a progesterone receptor (PGR) ...
Suhani Department of General Surgery, Lady Hardinge Medical College, New Delhi, - - 2014
Sarcomas are rare histological types of malignancy found in the breast. While angiosarcoma is the most common type of sarcoma found here, malignant fibrous histiocytoma (MFH) arising de novo is one of the rare varieties. We recently cared for a middle aged lady with a locally advanced fungating growth in ...
Mambili-Mamboundou Hermane H University of Kwazulu Natal School of Mathematics, Statistics, and Computer Science Private Bag X01, Scottsville, Pietermaritzburg, 3209 South Africa. Electronic address: - - 2014
There is clinical evidence that some people have lived with a benign tumour for their entire life time. This is explained by cancer dormancy which is attributed to the interaction of tumour infiltrating cytotoxic lymphocytes (TICLs) with tumour cells. We present two mathematical models to study the mechanism of interaction ...
Auger Manon M Department of Pathology, McGill University and McGill University Health Center, Montreal, PQ, - - 2014
Although the cytological assessment of Hürthle cell lesions is challenging, the literature offers good, albeit imperfect, guidance to aid in the crucial distinction between nonneoplastic and neoplastic lesions. The significance of a cytologic diagnosis of follicular neoplasm, Hürthle cell type, lies in the rate of malignancy on follow-up surgical excision, ...
Baba Youichirou Y Department of Pathology, JA Suzuka General - - 2014
A 53-year-old woman was referred to our hospital with a round, discolored lesion measuring 4mm in diameter that was identified as a minute gastric signet ring cell carcinoma. According to the Japanese classification of gastric carcinoma, it was graded as type 0-IIb. Seven years back, the woman had undergone pylorus-side ...
Chang Liang L Department of Neurosurgery, The Tumor Hospital, Harbin Medical University, Harbin, People's Republic of - - 2014
ABO blood groups have been suggested to contribute to the development of certain tumors; however, the associations between ABO blood groups and the incidence and metastases of cutaneous malignant melanomas have not been fully evaluated in Chinese populations. Thus, we investigated these associations with a case-controlled study in northeast of ...
Abhishek Sasidharan S Government Medical College, Calicut, Kerala, - - 2014
Biliary cystadenomas are cystic hepatic tumours of biliary origin. Cystadenomas are often slow-growing benign tumours, but always harbour the risk of malignant transformation. Cystadenomas are often asymptomatic, but may present with abdominal pain and distension. Though suspected with cross-sectional abdominal imaging, definitive diagnosis almost always requires histology. Spontaneous rupture of ...
Venyo Anthony Kodzo-Grey AK Department of Urology, North Manchester General Hospital, Delaunays Road, Crumpsall, Manchester, - - 2014
Background. Nested variant of urothelial carcinoma was added to the WHO's classification in 2004. Aims. To review the literature on nested variant of urothelial carcinoma. Results. About 200 cases of the tumour have been reported so far and it has the ensuing morphological features: large numbers of small confluent irregular ...
Panda Ananya A Senior Resident, Department of Radiodiagnosis, Dr BR Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences , Ansari Nagar, New Delhi-110029, India - - 2014
Growing teratoma syndrome is characterized by conversion of immature gonadal germ cell tumour to a mature form, along with increase in size of the lesions. Being more frequently described in testicular germ cell tumours, growing teratoma syndrome in an ovarian tumour is uncommon. The exact cause of conversion and growth ...
Prabhu Raghunath R Department of Surgery, Kasturba Medical College, Manipal, Karnataka, - - 2014
A 28-year-old woman presented with colicky abdominal pain for 3 months. Pain was associated with episodes of vomiting, abdominal distension and constipation. She also had loss of weight for this duration. General physical examination was unremarkable and the abdomen was soft, with no palpable organomegaly. A CT of the abdomen ...
Shukla Shailaja S Department of Pathology, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi, - - 2014
Persistent high risk human papilloma virus (HPV) infection is probably the best predictor of increased risk of cervical cancer, but expression of certain markers of cell proliferation and apoptosis have been studied. The present study was conducted to evaluate the expression of p53 and bcl2 in premalignant and malignant lesions ...
Chowdhoury Satyabrata Roy - - 2013
The authors report an 11-mo-old child presenting with acute onset appearance of large, erythematous, palpable purpuric lesions involving face, extremities and trunk. Skin biopsy from the margin of the lesions showed leukocytoclastic vasculitis suggesting a diagnosis of acute hemorrhagic edema of infancy. This rare type of cutaneous vasculitis, despite its ...
Reddy Ashvini K - - 2013
To describe chorioretinal lesions in pediatric uveitis that are strongly associated with the HLA-DR,DQ Class II type associated with tubulointerstitial nephritis and uveitis (TINU). Retrospective, observational case series. Fourteen of the 15 patients (93%) with otherwise unexplained pediatric panuveitis typed HLA-DRB1*01-HLA-DQB1*05. Eleven of 15 (73.3%) had bilateral sharply demarcated, usually ...
Correa R R Department of Psychiatry, University of California San Diego (UCSD), USA. Electronic address: - - 2013
The life and artistic legacy of Vincent van Gogh has generated great interest among physicians from different areas of specialization in proposing a retrospective differential diagnosis. The aim of the present study is to present a systematic pathographic analysis of the artist and to suggest a diagnosis consistent with the ...
Lakshiminarasimhaiah Geetha G Assistant Professor, Department of Neuroanaesthesia, Ramaiah Medical College Bangalore-560054, Karnataka, India - - 2013
Neurofibromatosis type 2 is a genetic disorder with autosomal dominant pattern. It can manifest as intracranial, spinal, ocular and cutaneous lesions. The lesions can extend to all the systems. We present an anaesthetic management of a paediatric patient with neurofibromatosis 2 for multiple spinal and thoracic tumour decompression.
Teli Bhavuray B Assistant Professor, Department of General Surgery, Dmwims , Wayanad, Kerala-673577, India - - 2013
Adult intussusception is relatively rare in patients with bowel obstructions. Adult invagination is mostly caused by benign tumours. Intussusceptions caused by inflammatory fibroid polyps (IFPs) are uncommon. IFPs are rare, localized, non-neoplastic lesions originating in the submucosa of the gastrointestinal tract. We are reporting a rare case of intestinal obstruction ...
Misago Noriyuki - - 2013
: A relationship between the palisaded encapsulated neuroma (PEN) and the mucocutaneous neuroma seen in multiple endocrine neoplasia (MEN) 2b syndrome has been noted. We experienced a case of multiple mucocutaneous neuromas including both MEN 2b type neuromas and PENs. We evaluated the histopathologic and immunohistochemical features of 48 lesions ...
Argyris Prokopios P - - 2013
Fibromas are the most common soft tissue lesions of the oral cavity and are generally attributed to trauma. Koilocytic dysplasia refers to human papillomavirus (HPV)-related epithelial cytopathic effect. Koilocytic dysplasia is considered neoplastic. Herein, we report a case of oral fibroma with HPV-induced dysplastic changes of the surface epithelium confirmed ...
Salvatore Serena - - 2013
Cystic macular lesions frequently contribute to impaired visual acuity in hereditary retinal dystrophies. Their pathogenesis varies and is not entirely understood. Carbonic anhydrase inhibitors have proven to be potentially efficacious, although not in all cases. We discuss the various factors and mechanisms implicated in the etiology of cystic macular lesions ...
Jung Sungmi - - 2014
Although differentiating reactive urothelial atypia from urothelial carcinoma in situ (CIS) relies primarily on histologic evaluation, confirming the morphologic impression using immunohistochemistry (IHC) has been increasingly used in routine clinical practice. The aims of this study are to confirm the utility of commonly used markers (CK20, P53) and to test ...
Iriuchishima Takanori - - 2013
The correlation between anterior cruciate ligament (ACL) condition and patella osteoarthritic (OA) changes has not been well reported. The aim of this study was to reveal the correlation between ACL deterioration and the morphology of OA changes in the patella. The hypothesis was that significant correlation between ACL deterioration and ...
Pickup Michael M Vanderbilt University Medical Center, Vanderbilt-Ingram Comprehensive Cancer Center, Medicine and Pathology, Cancer Biology, 2220 Pierce Avenue, 691 Preston Research Building, Nashville, Tennessee 37232, - - 2013
The influence of the microenvironment on tumour progression is becoming clearer. In this Review we address the role of an essential signalling pathway, that of transforming growth factor-β, in the regulation of components of the tumour microenvironment and how this contributes to tumour progression.
Pierce Campbell Christine M - - 2013
Cutaneous human papillomaviruses (HPVs) may be associated with cutaneous epithelial lesions and non-melanoma skin cancers. No study has systematically evaluated the presence of genus beta [β]-HPV in male genital skin or external genital lesions (EGLs) OBJECTIVES: To examine cutaneous β-HPV types detected on the surface of EGLs in men and ...
Apostolou G - - 2013
It is said to be difficult to interpret the different endometrial lesions by cytomorphology; however, evaluation of the microarchitecture of the cell clumps and application of immunocytochemistry can improve diagnostic accuracy. The aim of the present study was to evaluate cytolomorphological features and correlate them with the histological diagnosis of ...
Takemura Kosuke K Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, - - 2013
Recently, overexpression of γ-glutamylcyclotransferase (GGCT) has been reported in various cancer tissues suggesting that it has significant potential as a diagnostic marker. The aim of this study was to examine the suitability of GGCT for the detection of high-risk lesions at an early stage of esophageal squamous cell carcinoma (ESCC). ...
Lee Kwang Won - - 2013
Various shapes of congenital abnormalities of the meniscus have been reported. Among them, the double-layered meniscus is rare. This article describes a 22-year-old man with a double-layered lateral meniscus who reported right knee pain with no history of trauma. The double-layered lateral meniscus included both the upper and lower meniscus. ...
Sikri Vikas - - 2013
Askin tumour, a primitive neuroectodermal tumour of the thoracopulmonary region, is a rare tumour presenting in childhood. Its presentation in adults is rare. We report a case of an Askin tumour in an adult patient who presented to us with worsening breathlessness and vague chest pain. Investigations including immunohistochemistry confirmed ...
Yu Lu - - 2013
Pleuropulmonary blastoma (PPB) is a rare malignant dysontogenetic neoplasm primarily affecting younger children, even in newborns with an unfavorable outcome. PPB is histologically composed of a primitive, variably mixed blastematous and sarcomatous components, and exclusively subclassified as type I (purely cystic), type II (both cystic and solid elements) and type ...
Raigani Siavash - - 2013
Sacrococcygeal teratoma is the most common type of extragonadal germ cell tumor in infants and young children. Sacrococcygeal teratomas can uncommonly present in an intra-abdominal fashion, with minimal clinical findings. Dermatologic lesions overlying the vertebrae or buttocks are often associated with sacrococcygeal teratoma and may be the only clue to ...
Smith Neil R - - 2013
The aim of the study was to investigate the vascular and stromal architecture of pre-clinical tumour models, and patient tumour specimens from malignancies with known clinical outcomes to VEGFi treatment, to gain insight into potential determinants of intrinsic sensitivity and resistance. The tumour-stroma architecture of pre-clinical and clinical tumour samples ...
Al-Mahdi Akmam H - - 2013
First branchial cleft anomaly is a rare disease of the head and neck. It accounts for less than 8% of all branchial abnormalities. It is classified into type I, which is thought to arise from the duplication of the membranous external ear canal and are composed of ectoderm only, and ...
Khandeparkar Siddhi Gaurish Sinai SG Department of Pathology, Shrimati Kashibai Navale Medical College and General Hospital, Pune, Maharashtra, - - 2013
Primary localized congenital sacrococcygeal neuroblastomas (SCNs) are rare. Diagnosis is based on histological and immunohistochemical evaluation, which is indispensable not only for determining tumor type but also for predicting biological behavior. We report a rare case of congenital SCN in a 9-month-old baby girl. Based on clinical and radiological findings, ...
Kumar Rajesh R Department of Periodontology, Sri Aurobindo College of Dentistry, Indore, Madhya Pradesh, - - 2013
Congenital granular cell tumor (CGCT), or congenital epulis, is an uncommon benign soft tissue lesion that usually arises from the alveolar mucosa of neonates and may cause respiratory and feeding problems. The histogenesis and clinical history of the lesion remains obscure. Treatment involves surgical excision and recurrences are rare. The ...
Varello K - - 2013
Mycobacterium spp. and Photobacterium damselae subsp. piscicida are recognized as the most frequent causative agents of granulomatous lesions in fish. Although frequent episodes of mycobacterial infections have been reported in wild fish worldwide, only sporadic cases have been documented to date in Italy. To investigate for the presence of lesions ...
Aiki Minako - - 2013
Myofibroma is a rare benign tumor of myofibroblasts that rarely exhibits rapid enlargement and is misinterpreted as a malignant lesion. The aim of this study was to investigate its growth potential and to evaluate the usefulness of preoperative immunohistochemical study for an accurate diagnosis. A case of rapidly growing myofibroma ...
Vasudev N S - - 2013
Background:We examine how changes in a surrogate marker of tumour vessel density correlate with response and resistance to anti-angiogenic therapy.Methods:In metastatic renal cancer patients treated with anti-angiogenic tyrosine kinase inhibitors, arterial phase contrast-enhanced computed tomography was used to simultaneously measure changes in: (a) tumour size, and (b) tumour enhancement (a ...
Lee Michael - - 2013
Diffuse peritoneal mesothelioma (DPM) forms a spectrum of indolent surface tumours to malignant invasive cancers. There are few pathological series that span well and poorly differentiated lesions that show diffuse peritoneal spread. Sixty-four DPM treated by initial cytoreductive therapy were retrospectively reviewed. Tumours were classified by surface and invasive growth ...
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