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Crisan Diana D Department of Histology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, - - 2014
Dermatofibroma (benign fibrous histiocytoma) represents one of the most common skin tumors. We present the case of a 52 year old female patient with a highly pigmented nodular lesion, localized on the right thigh. Dermoscopy completed the clinical diagnosis, but could not exclude a malignant tumour . Ultrasound examination (Dermascan ...
Bergmann Frank F Institute of Pathology, University of Heidelberg, Heidelberg D-69120, - - 2014
The biology of pancreatic acinar cell cystadenomas has not been clearly defined. However, a non-neoplastic process, caused by a cell differentiation failure leading to a cystic transformation, has been discussed, as well as a benign neoplastic lesion. Pancreatic acinar cell cystadenomas usually consist of thin-walled unilocular or multilocular cysts, and ...
Jain Prabha P Department of Radiology, Middlemore Hospital, Manukau, New Zealand (P.J.); and Department of Surgery, University of Auckland, Auckland, New Zealand (R.J.). - - 2014
Plunging ranulas have been shown to have a common trio of mylohyoid defects, sublingual gland herniation, and submandibular space fluid collections. The herniated sublingual gland may be susceptible to subclinical trauma. The purpose of this study was to investigate the frequency of occurrence of various types of active sublingual gland ...
Droy-Dupré Laure L CHU Nantes, Service d'Anatomie et Cytologie Pathologiques, Nantes, - - 2014
Villous tumours of the rectosigmoid are historically defined as broad-based lesions associated with secretory diarrhoea. This study aimed to perform a reappraisal of these tumours, on the basis of newly introduced histological, immunohistochemical and molecular parameters. For this study, 22 villous tumours, diagnosed by endoscopic criteria (19 Paris 0-IIa, three ...
Sahora Klaus K Department of Surgery, Massachusetts General Hospital, Boston, MA; Department of Surgery, Harvard Medical School, Boston, - - 2014
The malignant potential of intraductal mucinous neoplasm of the pancreas (IPMN) is associated closely with main pancreatic duct (MPD) involvement. Because mixed-type IPMN is thought to have the same malignant potential as that of main-duct (MD)-IPMN, resection is recommended; however, the biological nature of mixed-type IPMN with only minimal involvement ...
Alaeddini Mojgan M Dental Research Centre, Tehran University of Medical Sciences, Tehran, - - 2014
In addition to ultraviolet radiation exposure, various molecular markers may differ between oral mucosal and cutaneous head and neck melanomas and lead to variations in their biologic behavior and prognosis. The aim of this study was to compare four such markers, namely microphthalmia transcription factor (MITF), P75, P53, and Ki-67 ...
Yoshida Rui - - 2014
Epidermodysplasia verruciformis is a rare genodermatosis characterized by a unique susceptibility to cutaneous human papillomaviruses infection. Most patients show autosomal recessive patterns of inheritance. We report a case of two sisters with clinically epidermodysplasia verruciformis specific lesions on the face, neck, trunk, and extremities. PCR analysis indicated the presence of ...
Wang Yiying - - 2014
BackgroundSerous tubal intraepithelial carcinoma (STIC) and the p53 signature in tubal mucosa have been supported to be precursor lesions in high-grade serous carcinoma (HGSC) of the fallopian tube, ovary, and peritoneum. It remains critical to find biomarkers for precursor lesions in order to detect HGSCs efficiently. IMP3 is an oncoprotein ...
Yamane L S LS Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, - - 2014
Colorectal cancer (CRC) is one of the most frequent cancers worldwide. Adenoma is the main precursor lesion and, recently, the serrated polyps were described as a group of colorectal lesions with malignant potential. The morphologic and biologic characterizations of serrated polyps remain limited. The aim of the present study was ...
Preti Mario M Gynecological Oncologist, Department of Obstetrics and Gynecology, University of Turin, Via Ventimiglia 3, Turin, Italy. Electronic address: - - 2014
Vulvar intraepithelial neoplasia (VIN) is a high-grade intraepithelial squamous lesion and precursor of invasive squamous cell carcinoma (SCC). The 2004 International Society for the Study of Vulvovaginal Disease (ISSVD) classification distinguished two types of VIN: usual type (human papillomavirus (HPV)-related) and differentiated type (not HPV-related). The incidence of usual-type VIN ...
Singh Naveena N Departments of *Cellular Pathology ‡Gynecological Oncology, Barts Health NHS Trust, London, United Kingdom †Department of Pathology, Sunnybrook Health Sciences Centre, Toronto, ON §Department of Pathology ∥Division of Gynecological Oncology, Vancouver General Hospital, Vancouver, BC, - - 2014
The pathogenesis of vulvar squamous cell carcinoma follows 1 of 2 distinct pathways. A precursor lesion in the human papilloma virus-independent pathway, differentiated vulvar intraepithelial neoplasia (dVIN), was only recently characterized in detail and is infrequently diagnosed without an associated component of invasive carcinoma. Aberrant p53 immunostaining is frequently seen ...
Kim Eun Soo ES Department of Radiology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of - - 2014
Malignant transformation or recurrence of intracranial mature teratoma is an extremely rare occurrence, compared to the usual ovarian counterpart. Previously, yolk sac tumor elements have been considered to be selective progenitors of enteric-type adenocarcinoma arising from intracranial germ cell tumors. However, the present case demonstrates the occurrence of enteric-type adenocarcinoma ...
Watanabe Gen G Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, - - 2014
Although intestinal-type epithelium in Barrett's oesophagus has been traditionally recognised as having a distinct malignant potential, whether this also holds true for cardiac-type epithelium remains controversial. The aim of this study was to identify highly associated type of epithelium with Barrett's tumour. We analysed tumours and the corresponding background mucosa ...
Neri Iria I Division of Dermatology, Department of Specialized, Clinical and Experimental Medicine, University of Bologna, Bologna, - - 2014
Differential diagnosis between congenital Volkmann ischemic contracture (CVIC) and unilateral aplasia cutis congenita (ACC) type VII of the forearm presents a clinical challenge. Both diseases share the same clinical presentation characterized by a stellate ulceration over the upper extremities and reported association with neuromuscular defects, but the diagnostic criteria to ...
Eustace K K Department of Dermatology, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland, - - 2014
Lichen planus is an inflammatory mucocutaneous disorder, often idiopathic. It is postulated that the characteristic skin lesions arise from a T cell mediated autoimmune response against basal keratinocytes. Oral mucosal involvement can occur in up to 70 % of cases of cutaneous disease however, oesphageal involvement is rare. We report the ...
Meena Manju M Oculoplastic Unit, Department of Ophthalmology, Sydney Hospital and Sydney Eye Hospital , Macquarie Street, Sydney, NSW , Australia - - 2014
Abstract Purpose: To report an unusual presentation of a case of Lymphomatoid papulosis(LyP) in a young girl. Material and Methods: A 14-year-old female presented with a history of swelling of the left upper eyelid of two weeks duration. There was a history of trivial trauma prior to the swelling. The ...
Grey A A Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, - - 2014
Vemurafenib is a tyrosine kinase inhibitor of BRAF that prolongs survival in patients with BRAF V600-mutant metastatic melanoma. Secondary cutaneous malignancies are a well-documented toxicity of vemurafenib, thought to be mediated by enhanced ERK signalling in BRAF wild-type, RAS-mutant cells. Vemurafenib could also promote growth of non-cutaneous secondary malignancies by ...
Koo So-My SM Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, - - 2014
Malignant mesothelioma (MM) is the aggressive tumor of serosal surfaces. There are crude pathogenetic results regarding the biology of MM. Coordinated upregulations of p53 gene expression are shown in malignancies. We believed that there are changes in the p53 expression with transformation from reactive hyperplasia to MM. A 65-year-old male ...
Huff Wei X WX Department of Neurological - - 2014
Von Hippel-Lindau disease (VHLD) is characterized by a spectrum of benign and malignant tumors in the CNS and visceral organs. Rathke's cleft cysts are benign, nonneoplastic sellar lesions that are often asymptomatic. The authors report the case of twin sisters with VHLD Type 2C with radiographically similar sellar lesions. One ...
Nouraei S A Reza SA The National Centre for Airway Reconstruction, Department of ENT Surgery, Charing Cross Hospital , London W6 8RF , - - 2014
We present a system for classification of bilateral vocal fold mobility impairment. Type 1 obstructions are caused by bilateral laryngeal denervation, most commonly due to bilateral recurrent laryngeal nerve palsy. Type 2 obstructions are caused by crico-arytenoid joint ankylosis. Type 3 obstructions are due to inter-arytenoid granulation tissue. Type 4 ...
Bosse Kristopher R KR Division of Oncology, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, - - 2014
Malignant rhabdoid tumors (MRTs) are rare pediatric malignancies characterized by clinically aggressive lesions that typically show loss of SMARCB1 expression. We herein describe a case of a malignant rhabdoid tumor of the bladder in a 14-year-old male with an autism spectrum disorder and a de novo 3 Mb germline deletion ...
Aissa Khaoula K 1Faculté de médecine de Tunis, Université Tunis Elmanar. Hôpital Mohamed Tlatli de Nabeul, pediatrics, Nabeul, - - 2014
We have reported the first Tunisian case of triosephosphate isomerase (TPI) deficiency in a 2-year-old girl. She was the first child of a nonconsanguineous couple. The disease included a neonatal onset of chronic hemolytic anemia, recurrent low-respiratory infections then progressive neurological involvement. The diagnosis was made after her death from ...
Rekhi Bharat B Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, - - 2014
Papillary proliferations of the endometrium, without atypia have been uncommonly documented, including on cytology specimens. Herein, we present an uncommon case of a 55-year-old obese lady, on antihypertensive medications, who presented with history of irregular perimenopausal bleeding. A year ago, she was diagnosed with simple cystic hyperplasia on dilation and ...
Grimberg Jean J Institut de Recherche en Chirurgie Orthopédique et Sportive (IRCOS), 6 Avenue Alphonse XIII, 75016, Paris, France, - - 2014
To biomechanically compare Bankart lesion repair alone and Bankart lesion repair associated with infraspinatus capsulotenodesis described as «remplissage», in the treatment of combined Bankart and Hill-Sachs lesions. Seven pairs (right and left) of cadaveric shoulders have been tested, first without any lesion and then after performing a combined Bankart and ...
Imura Johji J Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, - - 2014
In spite of the evidence that the malignant transformation of gastric hyperplastic polyps (HPs) is a rare event, it must always be taken into account during diagnosis. The aim of the current study was to clarify the mechanism of the malignant transformation of gastric hyperplasia polyps, with focus on phenotypic ...
Ferreira Sabrina S From the Division of Oral and Maxillofacial Surgery and Traumatology, Department of Surgery and General Clinic, Araçatuba Dental School, Univ Estadual Paulista Júlio de Mesquita Filho-UNESP, Sao Paulo, - - 2014
Condylar hyperplasia (CH) is a pathologic condition that causes overdevelopment of the condylar head and neck as well as the mandible. Slowly progressive unilateral enlargement of the head and the neck of the condyle causes crossbite malocclusion, facial asymmetry, and shifting of the midpoint of the chin to the unaffected ...
Kim Kang-Il KI Department of Orthopaedic Surgery, Center for Joint Diseases and Rheumatism, Kyung Hee University Hospital at Gangdong, 892 Dongnam-ro, Gangdong-gu, Seoul, 134-727, - - 2014
The purpose of this study was to examine the arthroscopic anatomy of posteromedial capsule and magnetic resonance imaging (MRI) findings in internal derangement of the knee joint and to analyze the relationship between popliteal cysts and the posteromedial capsule. From 2011 to 2012, a prospective study included 194 knees of ...
Choi Chang In CI Chang In Choi, Dae Hwan Kim, Tae Yong Jeon, Dong Heon Kim, Department of Surgery, Medical Research Institute, Pusan National University Hospital, Seo-Gu, Busan 602-739, South - - 2014
Solitary Peutz-Jeghers type hamartomatous polyp is rare. It is considered to be related to a variant Peutz-Jeghers syndrome (PJS) and may be a separate disease entity. A 50-year-old man was referred to our hospital with a diagnosis of intussusception in the terminal ileum and underwent segmental ileal resection with appendectomy. ...
Tay Eugene E *Adnexal and Orbital Service, Moorfields Eye Hospital, London, United Kingdom; †Department of Ophthalmology, Singapore National Eye Centre, Singapore, Singapore; and ‡Department of Pathology, Institute of Ophthalmology, London, United - - 2014
Congenital respiratory epithelial cysts of the orbit are rare lesions with few reported cases. Extensive disease may cause an orbital apex syndrome, resulting in significant visual loss. Two such cases were described, the risk factors associated with surgical morbidity were identified, and the embryological origins of these cysts were reviewed.
Foulkes William D WD Department of Medical Genetics, Lady Davis Institute and Segal Cancer Centre, Jewish General Hospital, McGill University, Montreal, QC, Canada; Department of Medical Genetics, Research Institute, McGill University Health Centre, Montreal, QC, - - 2014
Whole exome sequencing (WES) is revolutionizing medical diagnostics and taxonomy. In less than five years since its first use, WES has revealed unexpected molecular drivers of numerous cancers. Here, we describe our use of WES to uncover the true nature of an enigmatic pathological entity, small-cell carcinoma of the ovary, ...
di Pietro Massimiliano M Medical Research Council, Cancer Unit, , University of Cambridge, Cambridge, - - 2014
Endoscopic surveillance for Barrett's oesophagus (BO) is limited by sampling error and the subjectivity of diagnosing dysplasia. We aimed to compare a biomarker panel on minimal biopsies directed by autofluorescence imaging (AFI) with the standard surveillance protocol to derive an objective tool for dysplasia assessment. We performed a cross-sectional prospective ...
Aydogdu Koray K Department of Thoracic Surgery, Atatürk Chest Diseases and Thoracic Surgery Research and Training Hospital, Ankara, - - 2014
Bronchogenic cysts are congenital malformations thought to originate from the primitive ventral foregut, and they are the most common type of mediastinal cystic lesion. The clinical presentation of a bronchogenic cyst is variable, from respiratory distress at birth to late appearance of symptoms. Most bronchogenic cysts originate in the mediastinum, ...
Abraham Susan C SC Department of Pathology, MD Anderson Cancer Center, Houston, - - 2014
Inflammatory and reactive conditions are known to mimic dysplasia or malignancy in the gastrointestinal tract. Epithelial atypia that closely mimics low-grade dysplasia (LGD) or high-grade dysplasia (HGD) can sometimes be seen in ischemic bowel. To study this phenomenon, we evaluated surgical resections for ischemic enteritis (n = 65) and ischemic ...
Gumaste Priyanka P *Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ; †Department of Dermatology, Dermatology Cosmetic and Laser Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ‡Department of Medicine-Division of Dermatology, UC San Diego, San Diego, CA; §Department of Dermatology, UC Irvine, Irvine, CA; ¶RBGB Dermatology, Santa Ana, CA; and ‖Laguna Pathology Medical Group, Laguna Beach, - - 2014
: Basaloid follicular hamartoma (BFH) is a rare, generally benign lesion of importance because of its clinical and histopathological similarity to infundibulocystic basal cell carcinoma. Autosomal dominant generalized BFH syndrome is 1 of the 5 clinical forms of BFH that has been described in the literature. We report a case ...
Horn Lars-Christian LC Division of Breast, Gynecologic & Perinatal Pathology, Institute of Pathology, University of Leipzig, Leipzig (L.-C.H.) Department of Obstetrics and Gynecology, Martin-Luther-University, Halle/Saale (U.K.B., H.-G.S, I.K.), - - 2014
The occurrence of ectopic intestinal/enteric-type epithelium at the vulva is a rare entity sometimes mimicking intraepithelial neoplasia or malignant disease. Here, we report a case of an 82-yr-old woman with a long-standing (10 yr) white papillary lesion with some reddish areas at her left labium, extending into the vaginal introitus. ...
Rodriguez-Gonzalez Marta M Pathology Department. University Hospital of Salamanca, Salamanca, Spain. - - 2014
Solitary pleuro-pulmonary fibrous tumours are relatively uncommon neoplasms that are difficult to manage therapeutically and which, cytogenetically, have been poorly studied. The aim of the present work was to analyse the characteristics of a series of consecutive operated solitary pleural fibrous tumours in an attempt to discover a malignant pattern ...
Tsai Jia-Huei JH 1] Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan [2] Graduate Institute of Pathology, College of Medicine, National Taiwan University, Taipei, - - 2014
Traditional serrated adenoma is one type of colorectal serrated neoplasm and a precursor of colorectal cancer. We evaluated the pathologic and molecular features of 60 traditional serrated adenomas with cytologic dysplasia and/or invasive carcinoma. On the basis of morphological features, 16 cases (27%) were categorized as traditional serrated adenoma with ...
Shahzad Rafia R Department of Radiology, INMOL Hospital, - - 2014
Neurofibromatosis type 1 (NF1) rarely affects the female genital system. Plexiform neurofibromas are congenital lesions that occur exclusively in patients with neurofibromatosis type I. The vulva is the most frequent genital organ to be affected, whereas vaginal, cervical, uterine, and ovarian neurofibromas have also been reported only rarely. We present ...
Miladi S - - 2014
Pleomorphic adenoma (PA), originally called mixed tumour, is the most common neoplasm of the salivary glands. It is usually a benign, slow-growing and well-circumscribed tumour. However, PA may occasionally give rise to metastases that usually occur after a previous recurrence. These tumours display benign histological features in both primary tumours ...
Ghalayani Parichehr P Department of Oral Medicine and Torabinejad Dental Research Center, Isfahan University of Medical Sciences, School of Dentistry, ISFAHAN, - - 2014
Focal epithelial hyperplasia or Heck's disease is an infrequent asymptomatic condition caused by human papillomavirus types 13 or 32 affecting the mucous membrane of the mouth and is commonly seen in young individuals. Firstly, it was described in Indians and Eskimos, but it exists in various populations. We present three ...
Göppner Daniela D Department of Dermatology and Venereology, Otto-von-Guericke University, Leipziger Str. 44, DE-39120 Magdeburg, - - 2014
There is growing evidence that not only malign keratinocytic but also melanocytic tumours can arise during treatment with vemurafenib. During an on-going early access trial, 13 patients harbouring a BRAF-V600E mutation received vemurafenib (Zelboraf®) 960 mg twice daily to test the safety, tolerability, efficacy and response rate for advanced melanoma. ...
Habiba Umma U Department of Oral Pathology and Biology, Hokkaido University Graduate School of Dental Medicine, Kita-ku, Sapporo 060-8586, - - 2014
Oral verrucous carcinoma (OVC) is a low grade variant of oral squamous cell carcinoma, and oral verrucous hyperplasia (OVH) is a benign lesion without malignant features. However, pathologists are sometimes presented with borderline lesions and are indecisive as to diagnose them as benign or malignant. Thus, these lesions are tentatively ...
Carriel Ictor I Department of Histology (Tissue Engineering Group), University of Granada, Granada, Spain, Department of Basic Medical Sciences, Faculty of Medicine, Ghent University, Ghent, Belgium, and Pathology Unit, San Camilo Hospital, University of Valparaíso, San Felipe, Chile. - - 2014
Gallbladder duplication is a rare congenital anomaly, with an incidence of 1 in 3,800 autopsies. The correct diagnosis and treatment of this type of entity is important in clinical practice, because it may cause some clinical and surgical problems. In this report, we present the clinical case of a 28-year-old ...
Vilela Maria Helena Tavares - - 2014
Adequate management of phyllodes tumors of the breast (PTB) remains a challenge because of the difficulty in correctly establishing preoperative diagnosis. The aim of this study was to evaluate the usefulness of Ki-67, CD10, CD34, p53, CD117, and of the number of mast cells in the differential diagnosis of benign ...
Yener Neşe Arzu NA Department of Pathology, Maltepe University Faculty of Medicine, Istanbul, - - 2014
Colorectal flat adenomas (FAs) may represent a different histogenesis, since their malignant potential is thought to be higher than polypoid adenomas of the same size. In this study, we classified FAs of ≤5 mm into three subgroups-superficially elevated adenomas (SEAs), completely flat adenomas (CFAs), and depressed adenomas (DAs)-based on their ...
Heard Melissa E ME Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR - - 2014
Endometriosis, a steroid hormone-dependent disease characterized by aberrant activation of estrogen receptor signaling and progesterone resistance, remains intractable due to the complexity of the pathways underlying its manifestation. We previously showed that eutopic endometria of women with endometriosis exhibit lower expression of Krüppel-like factor 9 (KLF9), a progesterone receptor (PGR) ...
Suhani Department of General Surgery, Lady Hardinge Medical College, New Delhi, - - 2014
Sarcomas are rare histological types of malignancy found in the breast. While angiosarcoma is the most common type of sarcoma found here, malignant fibrous histiocytoma (MFH) arising de novo is one of the rare varieties. We recently cared for a middle aged lady with a locally advanced fungating growth in ...
Mambili-Mamboundou Hermane H University of Kwazulu Natal School of Mathematics, Statistics, and Computer Science Private Bag X01, Scottsville, Pietermaritzburg, 3209 South Africa. Electronic address: - - 2014
There is clinical evidence that some people have lived with a benign tumour for their entire life time. This is explained by cancer dormancy which is attributed to the interaction of tumour infiltrating cytotoxic lymphocytes (TICLs) with tumour cells. We present two mathematical models to study the mechanism of interaction ...
Jain Kajal K *Departments of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India †Indian Agricultural Research Institute, New Delhi, India Departments of ‡Pathology §Surgery ¶Pediatrics (Genetics unit), and ‖Biostatistics, All India Institute of Medical Sciences, New Delhi, - - 2014
Causal association of gallbladder stones with gallbladder cancer (GBC) is not yet well established. To study the frequency of occurrence of preneoplastic histological lesions and loss of heterozygosity (LOH) of tumor suppressor genes in patients with gallstones. All consecutive patients with gallstones undergoing cholecystectomy from 2007-2011 were included prospectively. Histological ...
Auger Manon M Department of Pathology, McGill University and McGill University Health Center, Montreal, PQ, - - 2014
Although the cytological assessment of Hürthle cell lesions is challenging, the literature offers good, albeit imperfect, guidance to aid in the crucial distinction between nonneoplastic and neoplastic lesions. The significance of a cytologic diagnosis of follicular neoplasm, Hürthle cell type, lies in the rate of malignancy on follow-up surgical excision, ...
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