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Bongiovanni M M Institute of Pathology, Locarno, - - 2014
The application of molecular tests to thyroid fine needle aspiration (FNA) has been shown to be a valuable tool to better refine the pre-operative malignant risk of patients with indeterminate cytology results. In this study, we investigated the feasibility of using the laser capture microdissection (LCM) technique to obtain DNA ...
Harrison Claire N CN Department of Haematology Guy's and St Thomas' Hospital, London, UK - - 2014
The differential diagnosis of haematological abnormalities, such as leucocytosis, erythocytosis, thrombocytosis or indeed anaemia, is wide and disarming. Here we report on significant updates in the differential diagnosis of erythrocyosis and thrombocytosis presenting a simplified schema for the clinician. We then move to discuss significant advances in this field which ...
Gillis Amy A Department of Surgery, Trinity College Dublin, Dublin, - - 2014
Endoscopic ultrasonography with fine needle aspiration (EUS-FNA) has become an integral tool in the diagnosis of pancreatic cystic lesions (PCLs) and the analysis of molecular/DNA abnormalities might improve the accuracy of pre-operative diagnosis. A review was conducted of all studies using EUS-FNA aspirates of PCLs to assess the accuracy and ...
Stacchini Alessandra A Diagnostic Laboratory Department, Flow Cytometry Unit, Citta' della Salute e della Scienza, Turin, - - 2014
To evaluate the efficacy of the use of flow cytometry (FC) immunophenotyping together with fine-needle aspiration cytology (FNAC) in the diagnosis of thyroid lymphoma. FC was performed in parallel with FNAC in 35 samples of suspected thyroid lymphoma over a 12 years period. Results were correlated with histological or molecular ...
Gomes Carolina Cavalieri CC Department of Pathology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address: - - 2014
Oral leukoplakia (OL) is the most common potentially malignant lesion of the oral cavity, and OL diagnosis is a risk factor for developing subsequent oral squamous cell carcinomas (OSCC). Notably, loss of heterozygosity (LOH) profiles have been validated as risk predictors of malignant transformation of OL. Similar to other solid ...
Stacchini A A Flow cytometry unit, Diagnostic Laboratory Department, Citta' della Salute e della Scienza, Turin, - - 2014
Background: To evaluate the efficacy of the use of Flow cytometry (FC) immunophenotyping together with fine-needle aspiration cytology (FNAC) in the diagnosis of thryroid lymphoma. Methods: FC was performed in parallel with FNAC in 35 samples of suspected thyroid lymphoma over a twelve years period. Results were correlated with histological ...
Petinataud D D Structure de parasitologie-mycologie, département de microbiologie, hôpitaux de Brabois, centre hospitalo-universitaire de Nancy, 11, allée du Morvan, 54511 Vandœuvre-lès-Nancy, - - 2014
Onychomycosis is a frequent cause of nail infections due to dermatophytes. Molds and yeast may also be responsible of these pathologies. Antifungal treatments are frequently given without a mycological diagnosis, partly because of the requisite time for obtaining the biological results. The mycological diagnosis requires a direct microscopic examination and ...
Mraz Martin M Department of Nephrology, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, - - 2014
Hereditary xanthinuria (HX) is a rare inherited disorder caused by a deficiency of xanthine dehydrogenase/oxidase (XDH/XO). Missing XDH/XO activity leads to undetectable levels of uric acid excessively replaced by xanthine in serum/urine. The allopurinol loading test has been traditionally used to differentiate between HX types I and II. Final confirmation ...
Desjardin Clémence - - 2014
Osteochondrosis (OC(D)) is a juvenile osteo-articular disorder affecting several mammalian species. In horses, OC(D) is considered as a multifactorial disease and has been described as a focal disruption of endochondral ossification leading to the development of osteoarticular lesions. Nevertheless, OC(D) physiopathology is poorly understood. Affected horses may present joint swelling, ...
Kinoshita Yuichi Y Department of Pathology II, Kansai Medical University, Hirakata, Osaka, Japan; Division of Diagnostic Cytopathology and Histopathology, Kansai Medical University, Takii Hospital, Moriguchi, Osaka, - - 2014
The objective of the study was to evaluate the use of vitreous humor and/or intraocular perfusion fluid (IPF) from pars plana vitrectomy as a diagnostic and therapeutic procedure for intraocular diseases. The cytologic findings with respect to the clinical data, the anatomical findings, and the final diagnosis in 83 cases ...
Schmitt Fernando C FC 1Ipatimup and Medical Faculty of Porto University 2Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto 3Laboratoire National de Sante - - 2014
Currently, the use of molecular techniques is widely accepted on cytology as adjuvant of morphology for diagnosis and prognosis. Moreover, the study of markers of therapeutic response has been helpful in some types of neoplasms. There are many advantages in the use of cytological material to perform molecular studies: ease ...
Lakhani Sunil R SR University of Queensland, School of Medicine and UQ Centre for Clinical Research, The Royal Brisbane & Women's Hospital, - - 2014
The 4 edition of the WHO classification of Tumours of the Breast was published in 2012, as a separate volume from the gynae book. The editors and the international panel of breast pathologists have attempted to produce a consensus document that will help to standardize classification worldwide. In addition to ...
Swerdlow Steven H SH University of Pittsburgh School of Medicine, - - 2014
The field of hematopathology is ever-changing with important new discoveries of biologic and clinical importance. We continue to learn more about the clinical, morphologic, immunophenotypic and molecular/genetic features of the seemingly innumerable types of malignant lymphomas and their benign mimics. These discoveries have very pragmatic implications affecting our daily practice ...
Arps David P DP From the Departments of Pathology (Drs Arps, Chen, Fullen, and Hristov) and Dermatology (Drs Fullen and Hristov), University of Michigan, Ann - - 2014
Mycosis fungoides is the most common primary cutaneous lymphoma; however, it remains a significant diagnostic challenge, in part because of the overlap with several inflammatory dermatoses. Despite advances in immunohistochemistry and molecular diagnostics, false-positive, false-negative, and indeterminate diagnoses are not uncommon. In most cases, the overall balance of morphologic, immunophenotypic, ...
Su Tiefen - - 2014
BackgroundMetanephric neoplasms comprised a spectrum of kidney tumors containing renal epithelial or stromal cells or both, including metanephric adenoma, metanephric stromal tumor, and metanephric adenofibroma. The majority of cases were benign; only one case of ¿metanephric adenosarcoma¿ had been reported in the English literature.HistoryWe present the case of a 69-year-old ...
Haga Hiroaki H Department of Cancer Biology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA. - - 2014
Intrahepatic cholangiocarcinomas (iCCA) are primary intrahepatic malignancies originating from biliary epithelia. While both hepatocellular cancer and iCCA can present as mass lesions within the liver, these cancers are distinct in their morphology, etiology, pathology, natural history and response to therapy. There is a need for accurate and sensitive molecular markers ...
Law Chun-Yiu CY Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, - - 2014
Beta-ketothiolase deficiency is a rare inborn errors of metabolism (IEM) affecting the catabolism of isoleucine, characterized by severe ketoacidosis in children of 6 to 24months old. A prompt diagnosis is of paramount importance as the metabolic decompensation can be effectively reverted by glucose infusion and health outcomes are improved on ...
Lior-Hoffmann Lee L Department of Biology and ‡Department of Chemistry, New York University , 100 Washington Square East, New York, New York 10003, United - - 2014
DNA lesion bypass polymerases process different lesions with varying fidelities, but the structural, dynamic, and mechanistic origins of this phenomenon remain poorly understood. Human DNA polymerase κ (Polκ), a member of the Y family of lesion bypass polymerases, is specialized to bypass bulky DNA minor groove lesions in a predominantly ...
Nagaishi Masaya M Department of Neurosurgery, Koshigaya Hospital, Dokkyo University School of Medicine, 2-1-50 Minami-Koshigaya, Koshigaya-shi, Saitama 343-8555, Japan. Electronic address: - - 2014
Malignant gliomas of the optic pathway are rare, and their genetic alterations are poorly understood. We describe a 64-year-old woman with anaplastic astrocytoma originating from the optic pathway, together with the molecular features. She presented with progressive visual field loss, and a biopsy sample was obtained from the lesion in ...
Bhalla G G Himachal Institute of Dental Sciences , Paontasahib, HP , - - 2014
Collagenase-3 (matrix metalloproteinase-13) is a metalloproteinase (MMP) that is associated with bone lesions and exhibits variable expression patterns in odontogenic cysts; it may play a role in regulating focal proliferation and maturation of jaw cyst epithelium. We studied the localization, staining intensity and distribution of collagenase-3 in 13 periapical granulomas ...
Hakim Mumin Mushtaq Ahmed MM Department of Obstetrics and Gyneacology, Yenepoya Medical College, Mangalore, Karnataka, - - 2014
A 19-year-old unmarried woman with regular menstrual cycles presented with symptoms of vague abdominal pain of 1 month duration. General condition fair. Per abdomen-a firm, non-tender mass corresponding to 26 weeks of gestation with smooth surface, upper and lateral borders well defined, lower border not palpable was observed. Ultrasonography: left ovarian tumour ...
Thway Khin K Sarcoma Unit, Department of Histopathology, The Royal Marsden NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, - - 2014
Introduction. Soft tissue tumour pathology is a highly specialised area of surgical pathology, but soft tissue neoplasms can occur at virtually all sites and are therefore encountered by a wide population of surgical pathologists. Potential sarcomas require referral to specialist centres for review by pathologists who see a large number ...
Sanaei-Zadeh Hossein - - 2014
It is occasionally difficult to distinguish between a self-inflicted bruise and true bruise. The important point of diagnosis is a good, thorough history taking and detailed examination of the affected area. Keywords: artificial bruise - assault - heparin.
Luengo Olga O Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain ; Allergy Research Group, Institut de Recerca Vall d'Hebron, Barcelona, - - 2014
The knowledge on molecular allergy diagnosis is continuously evolving. It is now time for the clinician to integrate this knowledge and use it when needed to improve the accuracy of diagnosis and thus provide more precise therapeutic and avoidance measures. This review does not intend to comprehensively analyze all the ...
Charwudzi Alice A 0000-0001-8932-3735 Department of Chemical Pathology, University of Cape Coast School of Medical Sciences, Cape Coast, - - 2014
Background. FISH is a molecular cytogenetic technique enabling rapid detection of genetic abnormalities. Facilities that can run fresh/wet samples for molecular diagnosis and monitoring of neoplastic disorders are not readily available in Ghana and other neighbouring countries. This study aims to demonstrate that interphase FISH can successfully be applied to ...
Pastor-Valle J J Servicio de Parasitología, Centro Nacional de Microbiología, Instituto de Salud Carlos III Majadahonda, Madrid, - - 2014
Human diphyllobothriasis is sporadically detected in Spain. Diphyllobothrium latum and Diplogonoporus balaenopterae have been identified. In the study, four cases of presumably imported diphyllobothriasis in Spanish patients were appraised. Molecular diagnosis allowed us to identify 'exotic' fish tapeworms such as Diplogonoporus balaenopterae in one patient and Diphyllobothrium pacificum in the ...
Oezkan F F Department of Interventional Pneumology, Ruhrlandklinik, University Hospital Essen, University of Duisburg-Essen, Essen, - - 2014
The assessment of an increasing number of molecular markers is becoming a standard requirement from endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) specimens. However, it is unclear how many needle passes should be performed and the amount of lung cancer cells that should be sent for molecular analyses. The objective of ...
Kondo Fukuo F Department of Pathology at Teikyo University Hospital, Tokyo, - - 2014
There are various types of benign hepatocellular nodular lesions, and their diagnostic criteria were formulated in detail. However, in 2010, the new World Health Organization (WHO) classification introduced immunohistochemical diagnostic criteria for hepatocellular adenoma (HCA) reflecting molecular pathological properties, and HCA was classified into 4 subtypes. These criteria were useful ...
Wu Howard H - - 2013
To identify the subtypes of atypia of undetermined significance (AUS) that confers a different magnitude for the risk of malignancy (RM), thyroid fine-needle aspiration (FNA) cases carrying a diagnosis of "atypical follicular cells" or "follicular lesion" with surgical pathology followup were included in this study. The direct smears of the ...
Thomas Emily K - - 2013
To characterize the incidence, etiology, presenting complaint, clinical course, and outcome of cats with pneumomediastinum. Retrospective study from the period of January 1st, 2000 to December 31st, 2010. University teaching hospital. Forty-five cats with a radiographic diagnosis of pneumomediastinum. None. Medical and radiographic records were reviewed to identify cats with ...
Terada Tadashi - - 2013
The author investigated histopathology of 1,438 consecutive rectal specimens in the last 10 years of our pathology laboratory in Japan. A computer review of pathologic reports was done. Observations of pathologic slides were performed, when appropriate. The rectal specimens were composed of 1,022 benign lesions and 416 malignant lesions. The ...
Terada Tadashi - - 2013
The author reviewed 910 cases of consecutive esophageal biopsies in the last 15 year in the pathology laboratory of our hospital. There were 693 normal mucosa and benign lesions (76.2%) and 217 malignant lesions (23.8%). No significant changes were recognized in the esophagus in 50 biopsies (5.5%). In benign lesions, ...
Moslavac Sandra - - 2012
The aim of of the study was to investigate the possible changes of primary fine needle aspiration (FNA) diagnoses after subsequent check ups. We investigated 948 thyroid nodules and the main indications for repeat FNAs were inadequate/indeterminate FNA findings and growing nodules at ultrasound check up. FNA findings were subdivided ...
Singhi Aatur D AD Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, - - 2012
Pancreatic neuroendocrine tumors (PanNETs) are typically solid neoplasms but in rare instances may present as cystic lesions. This unusual presentation can make clinical diagnosis challenging. In addition, the clinical and histopathologic characteristics of cystic PanNETs are poorly defined. We identified 53 cystic PanNETs in our single-institution experience of 491 surgically ...
Tharwat Mohamed - - 2012
This study describes the transabdominal ultrasonographic findings in 54 goats with confirmed Johne's disease (JD). Compared with the control group (0.8 ± 0.4 mm thick), the test group presented with mild (2.8 ± 0.2 mm), moderate (4.2 ± 0.4 mm), and severe (6.9 ± 1.1 mm) thickening of the intestinal ...
Sandmann Gunther H - - 2012
Traumatic shoulder dislocation may be complicated by concomitant bony injury of the glenoid rim or the humeral head. In Hill-Sachs lesions, reconstruction techniques vary widely and range from open reduction to tendon transposition or humeral head derotation. These operations are extensive and have questionable outcomes. With the expertise from vertebral ...
Morvan G - - 2012
In this case series, out of 823 ultrasound-guided injections carried out over a period of one and a half years, 60% were of the lower limb (LL). In the hip (61% of LL injections), the main indications were pathologies of the gluteal tendons and bursae (80%) and pathologies of periprosthetic ...
Jain N - - 2012
Clinically equivocal abdominal wall lesions often pose diagnostic dilemmas for clinicians. It can be equally challenging to appreciate the nature of abdominal wall lesions found incidentally on abdominal ultrasound examinations. Ultrasound is a non-ionizing, cheap, and easily accessible investigation for such lesions. It is widely used and has the added ...
Raitz R - - 2012
OBJECTIVE: To analyse the visual perceptions of different experts with respect to multilocular radiolucent lesions in circumstances when the diagnosis is either known or unknown.Methods: 6 radiographs of ameloblastomas (AMELs), keratocystic odontogenic tumours (KOTs), central giant cell lesions (CGCLs) and myxomas (MIXs) were analysed by 16 dental experts [stomatologists/oral surgeons ...
Guo Bin - - 2012
The present study aims to evaluate the effect of Galla chinensis compounds on the remineralization of two artificial root lesions morphous in vitro. Sixty bovine dentine blocks were divided into two groups and individually treated with two levels of demineralization solutions to form erosive and subsurface artificial carious lesions in ...
D'Alessandro B - - 2012
Subsurface information about skin lesions, such as the blood volume beneath the lesion, is important for the analysis of lesion severity towards early detection of skin cancer such as malignant melanoma. Depth information can be obtained from diffuse reflectance based multispectral transillumination images of the skin. An inverse volume reconstruction ...
Ryu Hyeon Min - - 2012
Accurate evaluation of side branch (SB) ostium could be critical to the treatment of bifurcation lesions. We compared measured and calculated values of side branch ostial length (SBOL) in coronary bifurcation lesions with intravascular ultrasound (IVUS). Pre-intervention and post-intervention IVUS was performed in 113 patients who underwent stent implantation of ...
Buxbaum James L - - 2012
Rapid onsite evaluation (ROSE) has been demonstrated to correlate with final cytologic interpretations and improves the diagnostic yield of endoscopic ultrasound (EUS)-fine needle aspiration (FNA); however, its availability is variable across centers. The aim of this prospective study was to evaluate whether remote telecytology can substitute for ROSE. Consecutive patients ...
Macgregor Caitlin A - - 2012
INTRODUCTION: The method used to create a melanoma trainer using simulated back skin is presented. The trainer is intended to be used to teach medical students to identify benign and malignant cutaneous pigmented lesions. METHODS: Non-Hispanic and Hispanic white melanoma trainers were created using flexible polyurethane foam and pigmented silicone ...
Brouwer Patrick A - - 2012
In achondroplastic patients with slight complaints of medullary compression the cervical spinal cord regularly exhibits an intramedullary (CHII) lesion just below the craniocervical junction with no signs of focal compression on the cord. Currently, the prevalence of the lesion in the general achondroplastic population is studied and its origin is ...
Tsai Patrick - - 2012
The aim of this study was to determine the diagnostic accuracy of 2 cone-beam computed tomography (CBCT) machines and periapical (PA) radiography in detecting simulated apical lesions created with the smallest dental burs available. By using mandibles from human cadavers, simulated apical lesions were created and then progressively enlarged in ...
Seger M - - 2012
Cardiac cryoablation applied for treating cardiac arrhythmias has shown promising results after intervention particularly for the creation of elongated lesions. A model for simulating and assessing cryoablation interventions was developed, evaluated and validated with animal experiments. We employed two simulations of different freezing outlet settings for a loop shaped cryocatheter, ...
Tharwat Mohamed - - 2012
This study evaluated the use of ultrasonography for the diagnosis of Johne's disease in camels (Camelus dromedarius). Seventy camels with confirmed Johne's disease were examined by ultrasonography and subsequent necropsy; 15 healthy camels were included as controls. The most outstanding findings were visible enlargement of the mesenteric lymph nodes in ...
Hu Yipeng Y Centre for Medical Image Computing, University College London (UCL), London, - - 2012
What's known on the subject? and What does the study add? Transrectal ultrasonography (TRUS)-guided biopsies can miss prostate cancer and misclassify risk in a diagnostic setting; the exact extent to which it does so in a repeat biopsy strategy in men with low-intermediate risk prostate cancer is unknown. A simulation ...
Wood John W JW Department of Otolaryngology, University of Miami, Miami, Florida, USA. - - 2012
Benign lesions of the nasal cavity represent a diverse group of pathologies. Furthermore, each of these disorders may present differently in any given patient as pain and discomfort, epistaxis, headaches, vision changes, or nasal obstruction. Although these nasal masses are benign, many of them have a significant capacity for local ...
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