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Andersson Manne M Department of Clinical and Experimental Medicine, Surgery, Faculty of Health Sciences, Linköping University, Linköping, Sweden, - - 2014
The diagnosis of appendicitis is difficult and resource consuming. New inflammatory markers have been proposed for the diagnosis of appendicitis, but their utility in combination with traditional diagnostic variables has not been tested. Our objective is to explore the potential of new inflammatory markers for improving the diagnosis of appendicitis. ...
Hashimoto Takeshi T Department of Urology, Tokyo Medical University, Tokyo, - - 2014
To identify predictive factors for multifocal lesions in patients with upper tract urothelial carcinoma (UTUC). Between June 1996 and September 2013, a cohort of 147 patients underwent radical nephroureterectomy at our institution. Univariate and multivariate logistic regression analyses were performed to identify clinical covariates significantly associated with the multifocal UTUC ...
Tamarozzi Francesca F aDepartment of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia bDivision of Infectious and Tropical Diseases, "San Matteo" Hospital Foundation cWHO Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia, Italy dSwiss Tropical and Public Health Institutee University of Basel, Basel, - - 2014
Cystic echinococcosis is a chronic, complex, and neglected disease. The need for a simple classification of cyst morphology that would provide an accepted framework for scientific and clinical work on cystic echinococcosis has been addressed by two documents issued by the WHO Informal Working Group on Echinococcosis in 2003 (cyst ...
Bhat Amoolya A Department of Pathology, Sapthagiri Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, - - 2014
Fibroadenomas with a predominant cystic change are called cystic fibroadenomas. These are extremely rare forms of fibroadenomas and only one case has been reported so far. They are classified under the category of complex fibroadenomas. Complex fibroadenomas are a rare variant of fibroadenomas occurring in elderly females. They are characterized ...
Khurana Kamal K KK 1 Department of Pathology, State University of New York , Syracuse, New - - 2014
Abstract Objective: Advances in digital imaging methods have resulted in use of telecytology in the immediate assessment of fine-needle aspiration (FNA) specimens. We retrospectively compared the nondiagnostic rate for endoscopic ultrasound-guided (EUS) FNA of pancreatic lesions in two groups: one with on-site evaluation for adequacy via telecytopathology and the other ...
Jose Jean J Departmenst of Radiology (JJ, TM), Jackson Memorial Hospital, University of Miami Miller School of Medicine, Miami, FloridaOrthopedics (BL, LK), Jackson Memorial Hospital, University of Miami Miller School of Medicine, Miami, Florida - - 2014
We describe a sonographically guided technique to perform therapeutic injections for anteromedial ankle impingement syndrome. Scans are carried out using a high-frequency small footprint linear array transducer, positioned along the anteromedial aspect of the tibiotalar joint. A 25 gauge needle is advanced under direct sonographic guidance into the "meniscoid lesion" ...
Levman Jacob J Institute of Biomedical Engineering, University of Oxford, Parks Road, Oxford, OX1 3PJ, UK, - - 2014
Cancer screening with magnetic resonance imaging (MRI) is currently recommended for very high risk women. The high variability in the diagnostic accuracy of radiologists analyzing screening MRI examinations of the breast is due, at least in part, to the large amounts of data acquired. This has motivated substantial research towards ...
Betti R R Department of Health Sciences, Dermatologic Clinic, Università degli Studi di Milano, A.O. San Paolo, Milan, - - 2014
Geometric shapes have been suggested to be found in malignant melanomas. We have observed a number of melanomas presenting with linear and incomplete angulated figures. To verify the assumption that geometric shapes, a linear border and/or incomplete angulated figures may indicate a potential melanoma. Patients with surgically removed melanocytic lesions ...
Maier T T Department of Dermatology and Allergology, University Hospital of Munich, Munich, - - 2014
Lately, various smartphone applications have been introduced as diagnostic self-monitoring tools in the evaluation of pigmented moles, but most of these techniques have not been evaluated systematically. The purpose of this study was to evaluate prospectively the sensitivity and specificity of a recently developed smartphone application using fractal image analysis ...
Saravia M M Hospital Clínico Universitario de Valencia/INCLIVA, University of Valencia, Valencia, - - 2014
The distinction of Spitz and Reed nevi with atypical features from melanoma may be a difficult task. In these cases, the dermoscopic scores could bring variable results and not always correlate with the histologic diagnosis. The aim of this study was to compare the histopathologic and dermoscopic findings in a ...
Jung Min Jung MJ Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, - - 2014
Aspiration cytologic findings of mammary analogue secretory carcinoma (MASC), a newly established salivary gland neoplasm defined by a t(12;15)(p13;q25) ETV6-NTRK3 translocation, are not fully characterized to date. We report cytologic descriptions of nine cases of molecularly confirmed MASC, including two with unusual findings. Aspiration smears from nine MASCs of the ...
Salami A A Department of Pathology, University College Hospital, Ibadan, - - 2014
Intraoperative cytology is a cost-effective, rapid, and easy technique, and studies have shown good correlation between intraoperative cytology and histology. We undertook this study to compare the intraoperative cytology diagnoses of brain lesions made in our unit over a 10-year period with the definitive histological diagnoses. The aim was to ...
Sardana Divesh D Unit of Pedodontics and Preventive Dentistry, Oral Health Sciences Center, Post-Graduate Institute of Medical Education and Research, Chandigarh, - - 2014
Sinus histiocytosis with massive lymphadenopathy also known as Rosai-Dorfman disease is a rare, benign, histiocytic disorder of unknown origin characterized by lymphadenopathy. Since its original description by Rosai and Dorfman in 1969, small number of cases has been reported; hence no specific diagnostic criteria and treatment guidelines have been suggested. ...
Thompson Simon M SM Dept of Trauma and Orthopaedics, Chelsea and Westminster Hospital NHS Trust, London, - - 2014
The etiology of osteochondritis dissecans is hypothesized as repetitive microtrauma, resulting in an interruption of blood supply. Due to the location of the most common lesions on the medial femoral condyle, impingement of either the medial tibial spine or inferior pole of the patella against the adjacent medial femur may ...
Molina-Levya Alejandro A MD, Dermatology Consultant, Department of Dermatology, San Cecilio University Hospital, Granada, - - 2014
A Mediterranean Spanish woman, aged 56 years and in good health, presented with a nodule above her upper lip, which had rapidly evolved to central ulceration with crusting. As part of the work-up, samples were taken for microbiological and histopathological investigation. At the follow-up appointment the lesion had almost disappeared ...
Tuluc Madalina M Department of Pathology, Jefferson University Hospital, 132S 10th Street, Main Building, Philadelphia, PA 19107, USA. Electronic address: - - 2014
This article covers, in a comprehensive way, thyroid cytopathology. The Bethesda System for Reporting Thyroid Cytology is reviewed, with emphasis on the atypical and indeterminate diagnostic categories. Immunohistochemistry stains and molecular tests panels applicable to cytology specimens are described.
Karanian Marie M 1] Department of Pathology, Institut Bergonié, Bordeaux, France [2] INSERM U916, Bordeaux, France [3] Université de Bordeaux, Bordeaux, - - 2014
Cytogenetically, most dermatofibrosarcoma protuberans are characterized by chromosomal rearrangements resulting in the collagen type-1 alpha 1 (COL1A1)-platelet-derived growth factor β (PDGFB) fusion gene. This abnormality can be detected by fluorescence in situ hybridization (FISH) analysis in routine practice. The aim of this study was to evaluate the role of the ...
Steward David L DL Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0528, USA; Division of Endocrinology, Department of Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0528, - - 2014
Thyroid fine-needle aspiration biopsies are cytologically indeterminate in 15% to 30% of cases. When cytologically indeterminate thyroid nodules undergo diagnostic surgery, approximately three-quarters prove to be histologically benign. A negative predictive value of more than or equal to 94% for the Afirma Gene Expression Classifier (GEC) is achieved for indeterminate ...
Herman Alyssa M - - 2014
Baker's cyst, or popliteal cyst, is a fluid-filled mass that is a distention of a preexisting bursa in the popliteal fossa, most commonly the gastrocnemio-semimembranosus bursa. This bursa is unique in that it communicates with the knee joint, unlike other periarticular bursae, via an opening in the joint capsule posterior ...
Mohan Bhavna C BC Department of Oral Pathology and Microbiology, KLEVK Institute of Dental Sciences and Hospital, Belgaum, - - 2014
The drastic epidemiological transition has created a huge void in evidence with regard to the health statistics of elderly population. Data are sparse on the oral mucosal conditions prevalent among the elderly Indian population. This study aimed to review the oral biopsies reported in the institute over the last 21 years ...
Nakamura Manabu M Department of Maternal Fetal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi City, - - 2014
Aim: To evaluate the outcome of cases of prenatally diagnosed fetal ovarian cyst under conservative prenatal management. Methods: This retrospective cohort study included patients diagnosed between January 2005 and August 2013. They were managed expectantly during pregnancy and followed up until spontaneous regression of the cyst or postnatal surgery. The ...
Chae Hee-Dong HD From the Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, Seoul National University Medical Research Center, 101 Daehangno, Jongno-gu, Seoul 110-744, Korea (H.D.C., C.M.P., S.J.P., S.M.L., J.M.G.); Cancer Research Institute, Seoul National University, Seoul, Korea (C.M.P., S.J.P., J.M.G.); and Department of Biomedical Engineering, Division of Basic & Applied Sciences, National Cancer Center, Gyeonggi-Do, Korea - - 2014
Purpose To retrospectively investigate the value of computerized three-dimensional texture analysis for differentiation of preinvasive lesions from invasive pulmonary adenocarcinomas (IPAs) that manifest as part-solid ground-glass nodules (GGNs). Materials and Methods The institutional review board approved this retrospective study with a waiver of patients' informed consent. The study consisted of ...
Tsao Gabriel J GJ Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, 2380 Sutter Street, 2nd Floor, San Francisco, CA 94115, - - 2014
Fine needle aspiration biopsy (FNA) is the key step in selecting most patients with thyroid nodules for or against surgery. Accurate acquisition of cytologic samples from suspicious lesions is achieved by adding ultrasound guidance to optimize targeting as well as to enable sampling from nonpalpable lesions. This article discusses the ...
Reserva Jeave L JL *Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL; †Department of Pathology, University of California at San Diego, San Diego, CA; ‡Department of Pathology and Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR; §DermLogic, PLLC, PA, North Little Rock, AR; and ‖Department of Pathology, Orlando Health, Orlando, - - 2014
: Cutaneous ciliated cysts (CCC) are rare benign cysts known to occur in the lower extremities of females of reproductive age. Currently, there are 2 theories that attempt to explain the histogenesis of this rare entity. The theory of Mullerian heterotopia provides a plausible histogenetic explanation for the vast majority ...
Liu Hui H Department of Biomedical Engineering, Dalian University of Technology, Dalian 116024, - - 2014
To develop and evaluate a computerized semiautomatic segmentation method for accurate extraction of three-dimensional lesions from dynamic contrast-enhanced magnetic resonance images (DCE-MRIs) of the breast. The authors propose a new background distribution-based active contour model using level set (BDACMLS) to segment lesions in breast DCE-MRIs. The method starts with manual ...
Nasit Jitendra G JG From the Department of Pathology, Pandit Deendayal Upadhyay Government Medical College and Hospital, Gujarat, India. - - 2014
Well-differentiated papillary mesothelioma of the peritoneum (WDPMP) is an uncommon subtype of epithelioid mesothelioma. Usually, WDPMP has a benign course, while a few patients have multiple recurrence and malignant transformation on long-term follow-up. The histology of WDPMP has been well studied compared with the cytology. Although accurate diagnosis is based ...
Wang Ying - - 2014
Polymerase chain reaction (PCR) is an in vitro technique for the nucleic acid amplification, which is commonly used to diagnose infectious diseases. The use of PCR for pathogens detection, genotyping and quantification has some advantages, such as high sensitivity, high specificity, reproducibility and technical ease. Brucellosis is a common zoonosis ...
Sousa Michele Cardoso MC Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, UNESP, Univ. Estadual Paulista, São José dos Campos, São Paulo 12245-000, - - 2014
The present study aimed to investigate the efficiency of exfoliative cytology by correlating the clinical lesions of oral squamous cell carcinoma (OSCC) with exfoliative cytology and histopathological findings. Cases of OSCC diagnosed between 1984 and 2010 were analyzed. The inclusion criteria for the present study were the availability of detailed ...
Richmond Bryan K BK Department of Surgery, West Virginia University/Charleston Division, Charleston, West Virginia, - - 2014
The benign category of the Bethesda System for reporting thyroid cytopathology (BSRTC) predicts an incidence of malignancy from zero to three per cent. However, recent series report higher rates of malignancy ranging from eight to 14 per cent. Surgery is often performed for reasons other than their fine needle aspiration ...
Rago Teresa T Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa, - - 2014
Among several ultrasound patterns, thyroid nodule hypoechogenicity, spot microcalcifications, and an absent halo sign are used for predicting increased risk of thyroid malignancy. The predictive value of ultrasound, however, increases at the expense of its sensitivity, and malignancy is predicted with high specificity only when multiple ultrasound features are simultaneously ...
Cochran Abigail Maciolek AM Springfield, Ill. From the Department of Surgery, Institute of Plastic Surgery, Southern Illinois University School of - - 2014
Subungual melanoma typically presents as a darkened longitudinal stripe under the nail plate; however, this disease is frequently misdiagnosed, which leads to a delay in proper diagnosis. Subsequently, subungual melanoma historically has a relatively poor prognosis compared with other cutaneous melanomas, with the 5-year survival rate ranging between 16 and ...
Chen Xin X Department of Radiology, Wuhan Asia Heart Hospital, Wuhan, Hubei 430022, P.R. - - 2014
The aim of this study was to evaluate the clincal value of multi-slice spiral computed tomography (MSCT) in the diagnosis of double aortic arch (DAA) and analyze the associated angiography and 3D reconstruction imaging to increase the accuracy of DAA diagnosis. Clinical and imaging data from 15 patients diagnosed with ...
Kim Hoon-Soo HS Biomedical Research Institute, Pusan National University Hospital, Busan, - - 2014
Basal cell carcinoma (BCC) is the most common form of skin cancer and possesses various clinical features including translucency, ulceration, pigmentation, telangiectasia, and rolled borders. Accordingly, many cutaneous lesions can mimic BCCs and differential diagnosis is difficult. To clarify the differences in clinical characteristics between BCCs and BCC-mimicking lesions (BMLs), ...
Krill Michael M Medical Student, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, - - 2014
An anterior cruciate ligament ganglion cyst is an infrequent, but potentially clinically significant, cause of knee pain. Although the cyst may be removed surgically, percutaneous ultrasound-guided anterior cruciate ligament ganglion cyst aspiration and injection is feasible. To our knowledge, we present the first reported case description of utilizing ultrasound guidance ...
Barr Fritcher E G EG Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN, - - 2014
Pancreatobiliary tract carcinoma is a lethal disease with low survival rates and limited treatment options. Diagnosis is complicated by benign conditions that can mimic malignancy on radiological studies (e.g. primary sclerosing cholangitis or PSC) and the suboptimal sensitivity of endoscopic biopsy/brushings obtained by endoscopic retrograde cholangiopancreatography (ERCP). The detection of ...
Macedo Ana Cristina Lacerda AC *Laboratory of Epidemiology, and †Postgraduate Program in Health Sciences at the University of Extremo Sul Catarinense, Criciúma, Santa Catarina; and ‡Postgraduate Program in Medicine, Medical Sciences at the Federal University of Rio Grande do Sul, Porto Alegre, - - 2014
A systematic review was performed to estimate the accuracy of human epididymis protein 4 (HE4) assay in the diagnosis of ovarian tumors. A comprehensive search of the MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, Web of Science, SCOPUS, congress abstracts, and Grey literature (Google scholar; British ...
Gambichler T T Department of Dermatology, Ruhr-University Bochum, Bochum, - - 2014
High-definition optical coherence tomography scanners have recently been developed. To assess the diagnostic performance of HD-OCT in the differentiation of benign melanocytic skin lesions (MSL) and cutaneous melanoma (CM). Patients with MSL were assessed by HD-OCT. All diagnoses were histopathologically confirmed. One blinded observer evaluated both slice and en-face HD-OCT ...
Pereyra Lisandro L Division of Gastroenterology and Endoscopy, Department of Medicine, Hospita Alemán, Pueyrredón 1640, Buenos Aires, Argentina, - - 2014
Proximal colorectal cancer may arise from sessile serrated adenomas (SSAs). Recognition of these lesions during colonoscopy can optimize the endoscopic approach. We aimed to identify specific endoscopic features of SSA with conventional colonoscopy. Patients undergoing screening colonoscopies from January 2011 to September 2012, in whom colonic polyps were found, were ...
Gomez A A School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison 53706-1102. Electronic address: - - 2014
A balanced, parallel-group, single-blinded randomized efficacy study divided into 2 periods was conducted to evaluate the effect of a premix containing higher than typically recommended levels of organic trace minerals and iodine (HOTMI) in reducing the incidence of active digital dermatitis (DD) lesions acquired naturally and induced by an experimental ...
Mercier J J Service de sénologie et imagerie du sein, centre Jean-Perrin, 58, rue Montalembert, BP 392, 63011 Clermont-Ferrand cedex 1, - - 2014
Compare tomosynthesis to mammography, ultrasound, MRI, and histology for the detection and staging of BI-RADS 4-5 anomalies, as a function of breast composition, lesion location, size, and histology. Seventy-five patients underwent mammography, tomosynthesis, ultrasound, and MRI. The diagnostic accuracy of the different examinations was compared. The sensitivities for detection were ...
Srbova L L Department of Clinical Endocrinology, The Institute of Endocrinology, Prague, Czech - - 2014
To retrospectively reclassify the results of fine needle aspiration (FNA) cytology at our institution according to the Bethesda system for reporting thyroid cytopathology (TBSRTC), and to determine whether the introduction of the new classification system would have influenced the diagnostic accuracy compared with our existing system in which suspicious/indeterminate categories ...
Marghalani Siham S Department of Dermatology, Dermatopathology Section, Boston University School of Medicine, Boston, MA, - - 2014
Huntington interacting protein 1 (HIP1), an antiapoptotic protein normally expressed in the brain, is highly expressed in Merkel cell carcinomas (MCCs). Given this, the aim of the current study was to ascertain the value of HIP1 as a histopathologic adjunct in the diagnosis of MCC. In this retrospective study, archival ...
Nofal Ahmad A Department of Dermatology, Faculty of Medicine, Zagazig University, Zagazig, - - 2014
Generalized eruptive keratoacanthoma (GEKA) is an extremely rare variant of keratoacanthoma that poses significant diagnostic and therapeutic challenges. The study included three patients presenting with highly pruritic, generalized eruption of numerous small skin and flesh-colored follicular papules. They were mainly distributed on the face, neck, and trunk. Few larger nodules ...
Weledji Elroy P - - 2014
Gastrointestinal stromal tumours are the most common mesenchymal malignancies of the gastrointestinal (GI) tract and gastric leiomyosarcoma represent 1-3% of gastric malignancies. We report a case of a 69-year- old black African man who presented with a rare cause of gastric outlet obstruction and duodenal perforation. A Billroth- II gastrectomy ...
Kahi Charles J CJ Indiana University School of Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Indianapolis, Indiana; Richard L. Roudebush VA Medical Center, Indianapolis, Indiana. Electronic address: - - 2014
Serrated lesions are an important contributor to colorectal cancer (CRC), notably in the proximal colon. Findings in the distal colorectum are markers of advanced proximal adenomatous neoplasia. However, it is not known whether they affect the odds of advanced proximal serrated lesions. We performed a retrospective cross-sectional study of data ...
Mota de Almeida Fj F Department of Oral-and-Maxillofacial Radiology, Odontologiska fakulteten, Malmö University, Malmö, - - 2014
To determine whether the outcome of cone beam computed tomography (CBCT) examinations performed in accordance with the European Commission guidelines in a clinical setting has an impact on choosing diagnoses in endodontics. A prospective observational study was conducted. Fifty-three consecutive patients (81 teeth) from two different endodontic specialist clinics in ...
Sood Ruchit R Leeds Gastroenterology Institute, St James's University Hospital, Beckett Street, Leeds LS9 7TF, - - 2014
IBS is estimated to have a prevalence of up to 20% in Western populations and results in substantial costs to health-care services worldwide, estimated to be US$1 billion per year in the USA. IBS remains difficult to diagnose due to its multifactorial aetiology, heterogeneous nature and overlap of symptoms with ...
Liberman Rebecca F RF Massachusetts Department of Public Health, Boston, Massachusetts; - - 2014
We aimed to examine trends in timing of diagnosis of critical congenital heart defects (CCHDs) and factors associated with delayed diagnosis (diagnosis after discharge home following delivery). We examined a population-based retrospective cohort of CCHD cases among live births identified through the Massachusetts Birth Defects Monitoring Program. Congenital heart defects ...
Bruffaerts Rose R Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium; Neurology Department, University Hospitals Leuven, Leuven, - - 2014
We investigated the critical contribution of right ventral occipitotemporal cortex to knowledge of visual and functional-associative attributes of biological and non-biological entities and how this relates to category-specificity during confrontation naming. In a consecutive series of 7 patients with lesions confined to right ventral occipitotemporal cortex, we conducted an extensive ...
Martindale J J Wrightington Wigan and Leigh NHS Foundation Trust, Appley Bridge, UK; Lancaster University, Lancaster, - - 2014
The aim of the present study was to conduct an in-depth exploration of the 'journey' to diagnosis of people with ankylosing spondylitis (AS)/axial spondyloarthritis (Axial SpA) to gain insights into the experience, potential barriers and facilitators in this process. The present qualitative study, embedded within a prospective longitudinal cohort study, ...
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