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Houriet Carine C Department of Dermatology, Inselspital, University of Berne, Berne, - - 2014
BRAF inhibitors are broadly used for metastatic melanoma with BRAF mutations. Their use results in various cutaneous side effects, such as the development of keratoacanthomas and squamous cell carcinomas. We report a patient with metastatic melanoma treated with vemurafenib who developed dozens of histologically confirmed epidermal cysts within 2 months ...
Cho Suhyun S Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, - - 2014
Background: Cases of non-scarring alopecia after endovascular brain surgery have been reported, but dermoscopic findings of these lesions have rarely been published. Objective: To report the dermoscopic findings for alopecic skin lesions that developed after radiation exposure during angioembolization. Methods: Dermoscopic examination was used to evaluate alopecic skin lesions in ...
Daneshbod Yahya Y Department of Pathology, Dr. Daneshbod Pathology Laboratory, Shiraz, - - 2014
Solitary osseous plasmacytoma rarely involves the distal extremities. We report a case and provide a brief review of the relevant literature. We report a 64-year-old man who presented with swelling, mild pain and a deformed right index finger. The workup led to the diagnosis of solitary osseous plasmacytoma and the ...
Colonna Marco M Washington University School of Medicine, St. Louis, MO, USA. Electronic address: - - 2014
Dysregulated signals from the external environment and/or the internal milieu of the skin can lead to pathological conditions such as psoriasis. Di Meglio et al. (2014) show that the environment-responsive transcription factor AhR acts in keratinocytes to suppress psoriatic lesions.
Malik M M Nottingham University Hospital, Department of Dermatology, Queens Medical Centre, Nottingham, NG7 2UH, United - - 2014
Pyogenic granulomas are benign vascular tumours usually surgically treated by excision or curettage. The only topical therapy reported to date is imiquimod 5% cream but it produces a marked inflammatory response with discomfort generally worse than simple surgical excision or curettage. Here we report the use of timolol 0.5% ophthalmic ...
Kanaya Kohei K Department of Orthopedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan. Electronic address: - - 2014
To describe the technique of total dorsal capsulectomy alone for mucous cysts of the distal interphalangeal (DIP) joint and evaluate its outcomes and complications. Nineteen patients (18 women and 1 man) with 19 mucous cysts were treated by a total dorsal capsulectomy without cyst excision or osteophyte removal. The average ...
Amouyel-Castier Mélody M Department of Radiology, University Picardie Jules Verne, Place Victor Pauchet, Amiens, 80054, France, - - 2014
Lipofibromatous hamartoma is an uncommon benign tumor, usually unknown or misdiagnosed. We report the case of a 61-year-old patient presenting an acquired painful macrodactyly of the left thumb with paresthesia in the median nerve territory. Clinical examination reveals a tumefaction of the volar side of the wrist. She had a ...
Requena Camila Bueno CB Paulista State University Júlio de Mesquita Filho, UNESP, Botucatu, SP, - - 2014
Pachydermodactyly is a rare and benign form of acquired digital fibromatosis characterized by the expansion of soft tissue around proximal phalanges and interphalangeal joints. The etiology remains unknown, although it is suggested that repetitive mechanic trauma like the interlacing or rubbing of the fingers can lead to skin thickening. We ...
Picone Simonetta S Department of Maternal and Child Health, Division of Neonatology and Neonatal Intensive Care, Casilino General Hospital, ASL RM B, Roma, - - 2014
Congenital leukemia is a very rare severe condition and leukemia cutis may represent the presenting sign of this malignancy, sometimes preceding hematological findings of weeks. Typical clinical features include multiple red to purple papules, macules and nodules due to direct infiltration of the skin by malignant cells. We illustrate these ...
Fontaine C C Service de chirurgie de la main et du membre supérieur, pôle des neurosciences et de l'appareil locomoteur, hôpital Roger-Salengro, CHRU de Lille, rue du Pr-Emile-Laine, 59037 Lille cedex, France. Electronic address: - - 2014
This review outlines the skin, vascular and musculoskeletal symptoms affecting the hand during systemic inflammatory diseases other than rheumatoid arthritis. Skin lesions are diagnosed clinically and their symptomatology is documented through an extensive series of photographs. These conditions may require specific care before a surgical procedure can be performed. Vascular ...
Li Tian T Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing 400016, - - 2014
Cervical cancer is the principal cause of mortality due to cancer in women worldwide. New predictive markers may increase survival rates by improving the treatment of patients at a high risk for cancer. This study was carried out to investigate the amplification of human telomerase RNA component (hTERC) or/and c-MYC ...
Hudson Jena B JB From the Department of Pathology and Immunology, St Louis School of Medicine, Washington University, St Louis, - - 2014
Context.-Fine-needle aspiration (FNA) biopsy of salivary gland neoplasms can have a variety of overlapping appearances. Basaloid neoplasms can be a diagnostic challenge, and FNA cytomorphology alone cannot always provide a definitive diagnosis. Objective.-To examine the incidence and potential utility of detecting a MYB translocation by fluorescence in situ hybridization (FISH) ...
Rappaport A - - 2014
The case of a 34-year-old man with a fast growing hard lump on the fourth digit of the right hand is presented. Radiography and MRI of the finger showed the radiologic characteristics of a bizarre parosteal osteochondromatous proliferation. Pathologic analysis confirmed the radiologic diagnosis.
Bell Graham P GP Cancer Research UK London Research Institute 44 Lincoln's Inn Fields London, WC2A - - 2014
Human colorectal cancers arise as benign adenomas, tumours that retain their epithelial character, and then progress to malignant adenocarcinomas and carcinomas in which the epithelium becomes disrupted. Carcinomas often exhibit transcriptional downregulation of E-cadherin and other epithelial genes in an epithelial-to-mesenchymal transition (EMT), a mechanism first discovered in Drosophila to ...
Maire N N Department of Hand Surgery, Strasbourg University Hospital, 10, avenue Baumann, 67403 Illkirch cedex, - - 2014
The treatment of traumatic partial injuries of the flexor tendons of the fingers is seldom published. The only published clinical series states that the therapeutic approach depends on the existence or absence of a preoperative trigger. We hypothesized that the therapeutic attitude mainly depends on the percentage of the injured ...
Kim Jin Yong JY *Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea; †Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea; ‡Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea; and §Department of Pathology, Seoul National University College of Medicine, Seoul, - - 2014
: Acral lentiginous melanoma (ALM) is the most common type of cutaneous melanoma in Asian populations. Traditionally, ALM was believed to have a poorer prognosis than other subtypes of cutaneous melanoma because of its aggressive behavior. However, in Asians, there have been several unusual case reports that have shown only ...
Kumar Ashok A Department of Orthopaedics, Dubai Bone and Joint Center LLC, Dubai Healthcare City, Dubai, United Arab - - 2014
Bizarre parosteal osteochondromatous proliferation (BPOP; also called Nora's lesion) is a benign surface osteocartilaginous lesion, which is infrequently reported in world literature. The condition is classically described in the short tubular bones of hands and feet in the second and third decades of life. We present a case report of ...
Hashmi Atif Ali - - 2014
Fibro-osseous pseudotumor of the digit is rare benign lesion of subcutaneous tissue which is thought to be reactive process as a result of repeated trauma. We report a case of an ulcerated lesion of skin of middle finger, clinically thought to be leishmaniasis which after punch biopsy followed by excision ...
Jefferson Julie J Johns Hopkins Medicine. - - 2014
An otherwise healthy 71-year-old woman presented with an asymptomatic mass on her right 4th finger that had been slowly enlarging over the past 2 years. On physical examination, there was a tan-pink, freely mobile, rubbery 9-mm papule with a central keratotic plug located over the extensor aspect of the proximal ...
Pathade Smita Charandas SC Assistant Professor, Department of Pathology, DM WIMS , Wayanad, Kerala, India - - 2014
Giant Cell Tumours Of Tendon Sheath (GCTTS) are the second most frequent soft tissue tumours affecting the hand with an overall incidence of 1 in 50,000 individuals. These tumours are usually localized and solitary, with multiple GCTTS occurring rarely. Multi-centric origin is considered unusual and very few cases of multiple ...
Arora Rachita R Department of Pediatric Dentistry, Awadh Dental College, Jamshedpur, Jharkhand, - - 2014
A 25-year-old dental radiographer reported to the outpatient department with lesions at the lower and upper lips which had later spread to his finger. On the basis of the given history and clinical features, a diagnosis of primary herpetic infection on the mouth followed by secondary infection on the finger ...
Sano Kazufumi K Department of Orthopaedic Surgery, Dokkyo Medical University Koshigaya Hospital, Saitama 343-8555, - - 2014
Subcutaneous granuloma annulare is a benign inflammatory disorder consisting of deep dermal or subcutaneous nodules, and frequently occurring in the extremities and scalp in children. The occurrence of aggregated multiple nodules in a digit is quite atypical. This is a report of an eight-year-old girl who presented with increasingly asymptomatic ...
Nyhsen Christiane C CHS, Sunderland, - - 2014
A 30-year-old woman with no significant medical or family history presented with epigastric pain radiating to the right shoulder tip. She had an acute drop of haemoglobin within 6 h of admission. She was found to be actively bleeding from a ruptured simple ovarian cyst with no other pathology found. Bleeding ...
Pusztaszeri Marc P - - 2013
The distinction between adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA) on fine-needle aspiration biopsy (FNAB) can be challenging. Recently, a specific translocation t(6;9) involving the v-myb avian myeloblastosis viral oncogene homolog (MYB) and nuclear factor I/B (NFIB) genes was identified in ACCs, in which it contributes to MYB overexpression. ...
Flucke Uta - - 2013
Radiation-induced cutaneous vascular neoplasms occur infrequently and comprise benign, so-called atypical vascular lesions (AVL) and angiosarcomas (AS), often being high-grade malignant tumors. Both arise most frequently within previously irradiated skin in breast-conserving-treated mammary cancer patients. Because of the different clinical course and, consequently, different therapeutic approaches, histopathologic distinction of AVL ...
Kwan Julia M - - 2013
We present a case of a primary cutaneous carcinosarcoma (PCS). Histopathologically, PCS is defined as a biphasic tumor composed of malignant epithelial (carcinoma) and mesenchymal (sarcoma) elements. The diagnosis of PCS can be challenging, not only because of its rarity but also because superficial biopsies can result in sampling errors. ...
Pinto-Almeida Teresa - - 2013
Urticarial vasculitis is a rare clinicopathologic entity characterized by urticarial lesions that persist for more than 24 hours and histologic features of leukocytoclastic vasculitis. Patients can be divided into normocomplementemic or hypocomplementemic. The authors report the case of a healthy 49-year-old woman with a 1-year history of highly pruritic generalized ...
Hammadah Muhammad M Department of Internal Medicine, Cleveland Clinic, Cleveland, Ohio, United - - 2013
We are describing a case of 55-year-old obese female with significant history of uncontrolled rheumatoid arthritis, who recently had decreased her immune-suppression medications. She presented with extensive acral gangrene involving multiple fingers and toes. Clinical picture and laboratory findings were suggestive of vasculitis; however, skin biopsy established diagnosis of calciphylaxis, ...
Romero-Rojas Alfredo E - - 2013
Thyroid follicular neoplasms with signet ring cell morphology represent a challenging cytological and histopathologic diagnosis. The low frequency of these neoplasms and their broad differential diagnosis contribute to this difficult scenario. Here, we present an exceptionally rare case of thyroid follicular carcinoma with signet ring cell morphology in a 62-year-old ...
Ohtsuka Hisashi - - 2013
Abstract Vascular leiomyomas or angioleiomyomas are benign solitary smooth muscular tumours that rarely occur in the distal finger. I report a 64-year-old man with uncommon clinical appearance in the pulp of the middle finger.
Whittle Carolina - - 2013
Chondroid syringoma (CS) is an uncommon, benign epithelial skin mixed tumor. It is often located in the head and neck and is unusual in other parts of the body. It may be seen as a skin or soft tissue tumor. We present findings on high-resolution ultrasound and histology in a ...
Tanaka Shohei S Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Tokyo 162-8655, - - 2013
Acquired immune deficiency syndrome (AIDS)-related lymphoma (ARL) remains the main cause of AIDS-related deaths in the highly active anti-retroviral therapy (HAART) era. Recently, rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma. Here, we report a rare case of gastrointestinal (GI)-ARL with MYC rearrangements ...
Kim Min-Hyung - - 2013
Lipoma arborescens, a rare benign intra-articular lesion, is characterized by lipomatous proliferation of the synovium in which the subsynovial tissue is replaced by mature adipocytes. Subdeltoid bursa is a rare location for lipoma arborescens, and only a few cases have been reported in the literature. This article reports 2 cases ...
Dosal Jacquelyn - - 2013
: A 46-year-old white male with a history of HIV (CD4 245), acquired epidermodysplasia verruciformis, anal carcinoma in situ, hepatitis B and C presented with 3 asymptomatic, nontender, firm pink/skin-colored nodules involving the arm, left lateral leg, and right third finger. One year later, he developed a similar lesion on ...
Fodor Daniela - - 2013
The purpose of this pictorial essay is to illustrate the ultrasonographic aspects of the non-traumatic lesions of the fingers. Diffuse (especially dactylitis) and localized (tumors, tophi, calcinosis, etc) lesions of the digits are discussed and illustrated. For a better understanding, the US images are compared with the clinical aspect of ...
Lynch Douglas W - - 2013
Bizarre parosteal osteochondromatous proliferation (BPOP) or Nora's lesion is a unique, bony lesion that most often arises in the small bones of the hands and feet. The lesion was first described by Nora et al. in 1983, and documented cases have now shown the lesion to arise in the long ...
Joana Devesa Parente - - 2013
Malignant melanoma can present a variety of histopathological patterns. Cartilaginous change in the absence of osteogenic differentiation is extremely rare in malignant melanoma, being among the least frequent of the wide range of melanoma histologic patterns. We report a case of a 47-year-old woman with a subungual nodule on her ...
Accardo Giuseppe - - 2013
Histiocytoid haemangioma has been identified by Rosai in 1979 as a group of vascular tumour-like lesions. This lesion can occur in a wide variety of sites. Surgical excision is the treatment of choice. We present the case of a 35-year-old man with a swelling in the thenar region of his ...
Jessri M - - 2013
Lymphoma is a malignant neoplasm of component cells of the lymphoid system which is very rare in the jaws. Here we report a case of primary diffuse large B-cell lymphoma located in the periapical region of a mandibular molar which was misdiagnosed as chronic periapical periodontitis. The present case was ...
Issa Bassam - - 2013
Squamous cell carcinoma is the most common oral cancer of the head and neck region. Up to 50 percent of these cancers have spread by the time of diagnosis; therefore, early diagnosis is vital. Oral lichen planus and epithelial dysplasia are two of the most common types of oral lesions ...
Dahlin Lars B - - 2013
Abstract Glomus tumours are rare in adults, and such tumours may be associated with neurofibromatosis-1 (Nf-1). Here we describe successful treatment of two glomus tumours initially in the long finger and, one year later, in the thumb in a 17-year young girl with Nf-1.
Carreño Ana Maria - - 2013
Malignant Melanoma is a high mortality neoplasm. The involvement of the nail apparatus is rare, with only 2 out of 3 patients seeking medical attention as the result of recent nail melanocytic lesions. This results in late diagnosis and a prognosis worse than cutaneous melanoma. We report a female, presenting ...
Lee H-J - - 2013
Osteophyte excision is a mainstay of treatment for mucous cyst combined with Heberden's node in a distal interphalangeal joint or in an interphalangeal joint of the thumb. The aim of this study was to evaluate the results of osteophyte excision without cyst excision for the treatment of a mucous cyst ...
Pai Varadraj Vasant - - 2013
Pheohyphomycosis is a rare heterogeneous group of mycotic infections caused by dematiaceous (phaeoid) fungi affecting the skin, subcutaneous tissue, and central nervous system. Herein, we report a case of 29-year-old man with innocuous pustule over the right index finger. Examination revealed a subcutaneous swelling with pustules over the surface. Biopsy ...
Schade Alexander Thomas - - 2013
We present the case of a 44-year-old patient who crushed her ring finger in a door 4 months earlier. She was treated in the community for her chronic fingertip wound/pyogenic granuloma. As the lesion was not healing with regular wound management she was eventually referred to secondary care for an ...
Scolyer Richard A - - 2013
: Digital papillary adenocarcinoma (DPA) is a rare malignant adnexal tumour that occurs almost exclusively in a digital location. Only two case series have been reported previously. : To document the clinical and histopathological findings in a series of patients with DPA. : Of the 8 patients identified, six were ...
Moosvi Zama - - 2013
To investigate the role of c-Myc oncogene in selected odontogenic cysts and tumors. Ten cases each of ameloblastoma, adenomatoid odontogenic tumor (AOT), odontogenic keratocyst (OKC), dentigerous cyst, and radicular cyst were selected and primary monoclonal mouse anti-human c-Myc antibody was used in a dilution of 1: 50. Statistical Analysis was ...
Arora Kamal - - 2013
A male neonate was born to a sixth-gravida mother with a history of four early-neonatal deaths. On day 21 of life, the patient was admitted for poor feeding, vomiting and encephalopathy. Final diagnosis of propionic acidaemica (propionylcarnitine, 17.67 μmol/L) was made. He was managed by peritoneal dialysis followed by protein-free ...
Monacelli Giampaolo - - 2013
This article reports a case of GCRG seen in a young man with a rare double localization in the same finger and illustrates the degree of diagnostic difficulty and treatment. A 16-year-old man presented with dull pain and swelling of the left middle finger. Plain radiography of the hand showed ...
Leroux Maria Bibiana - - 2013
A 43-year-old, non-smoking man presented with acute ischemic lesions of his left hand. He had been taking beta-blockers for his arterial hypertension. The day before the occurrence of these acute lesions, he self medicated with a drug containing ergotamine and caffeine because of a headache. About one hour after mild ...
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