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Penn Edward B EB Jr Department of Otolaryngology, Monroe Carell Jr Children's Hospital, Vanderbilt University, 2200 Children's Way, DOT 7, Nashville, TN 37232, USA. Electronic address: - - 2015
The differential diagnosis in pediatric lymphadenopathy includes bacterial, viral, fungal, and idiopathic causes. A systematic approach to patient evaluation is necessary because the differential diagnosis, presentation, and work up must consider infectious, immunologic, neoplastic, and idiopathic disorders. A thorough history and examination are vital to determining the diagnosis and ruling ...
Mancini Nicasio N Laboratory of Microbiology and Virology, University Vita-Salute San Raffaele, Via Olgettina 58, 20132, Milan, Italy, - - 2015
The need of rapid and sensitive diagnostic techniques for sepsis is every day more compelling. Its morbidity and mortality loads are dramatically high, with one quarter of patients eventually dying. Several diagnostic progresses have been made in the last years using both molecular- and nonmolecular-based approaches, and they have to ...
Micheletti Robert G RG Departments of Dermatology and Medicine, Perelman School of Medicine at the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: - - 2015
Small vessel vasculitis in the skin manifests with palpable purpura on the lower extremities. This clinical presentation prompts a complete physical examination, history, and review of systems, as well as biopsies for routine processing and direct immunofluorescence to confirm the diagnosis. The presence of vasculitis in other organs, associated underlying ...
Stockfleth E E Klinik für Dermatologie, Venerologie und Allergologie, St. Josef-Hospital, Ruhr-Universität Bochum, Bochum, - - 2015
The new target for the treatment of actinic keratosis (AK) is the detection and clearance of clinical and subclinical lesions across an entire sun-exposed field. This is because patients with AK have field cancerization as ultraviolet light affects the entire sun-exposed area and because it is not possible to predict ...
LaPlante Justin K JK Department of Neuroradiology, University of Utah, 30 North 1900 East, #1A071, Salt Lake City, UT 84132, USA. Electronic address: - - 2015
Pediatric head and neck neuroradiology is a broad and complex topic. This article focuses on several of the common and sometimes challenging pediatric head and neck congenital/developmental anomalies physicians may encounter in clinical practice. Although some diagnoses may be evident on physical examination, others may present a diagnostic dilemma. Patients ...
D'Acunto Carmine C Department of Specialist, Diagnostic and Experimental Medicine, University of Bologna, Bologna, Italy; Department of Dermatology, S. Orsola-Malpighi Hospital, Bologna, - - 2014
From January 2010 to December 2012, 296 skin biopsies were performed in pediatric patients using only local anesthesia (cream and infiltration). The biopsies were divided into three groups: biopsies of skin neoplasms, biopsies of skin rashes and biopsies of follicular-centered lesions. Our data demonstrate the possibility of using this procedure, ...
Ruiter L L Department of Obstetrics & Gynaecology, Academic Medical Centre, Amsterdam, The - - 2014
Vasa previa (VP) are fetal blood vessels lying outside the chorionic plate in close proximity to the cervical internal os. In women with VP, the risk of rupture of these vessels is increased, thus potentially causing fetal death or serious morbidity. Our objective was to assess the accuracy of ultrasound ...
Emura Iwao I Department of Surgical Pathology, Japanese Red Cross Nagaoka Hospital, Nagaoka City, - - 2014
The mechanisms underlying the acute exacerbation of idiopathic pulmonary fibrosis are poorly understood. We identified minute lesions of alveolar damage in surgical lung biopsy samples from patients with stable idiopathic pulmonary fibrosis. We hypothesized that the foci may play roles in the development of acute exacerbation. We examined surgical lung ...
Gao Yang Y Orthopaedic Center, Zhujiang Hospital, Southern Medical University, 253 Gongye Dadao Zhong, Guangzhou, 510282, People's Republic of - - 2014
Horner syndrome (HS) results from the interruption of sympathic pathway, and the patients have a group of signs including miosis, ptosis, enophthalmos, and anhydrosis. While HS is mainly caused by cervical sympathetic nerve injury such as sympathetic chain tumor, we report here a HS case caused by a thoracolumbar arachnoid ...
Kim Ga Hee - - 2014
Metastasis to the stomach is rare. The aim of this study was to describe and analyze the clinical outcomes of cancers that metastasized to the stomach. We reviewed the clinicopathological aspects of patients with gastric metastases from solid organ tumors. Thirty-seven cases were identified, and we evaluated the histology, initial ...
Trisolini Rocco R Thoracic Endoscopy and Pulmonology Unit, Maggiore Hospital, Bologna, - - 2014
Literature suggests that ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has excellent performance characteristics for diagnosis of sarcoidosis. However, many authors challenge the external validity of EBUS-TBNA results, as most studies were performed in referral centres by highly experienced investigators, and included populations with very high sarcoidosis prevalence. We performed a systematic ...
Zhou Z Z Department of Dermatology, Chengdu Military General Hospital, Chengdu, Sichuan Province, - - 2014
Erosive pustular dermatosis (EPD) of the leg is an unusual form of amicrobial pustulosis, which typically affects elderly patients with chronic venous insufficiency. We report a patient who presented with painful erythema, crusted erosions and pustules on her right lower leg. Histology showed a dermal infiltration made up predominantly of ...
Auschwitz Tyler T Department of Neurosurgery, University of Tennessee Health Science - - 2014
Intracranial arachnoid cysts are a rare condition thought to be congenital in nature. Treatment of intracranial arachnoid cysts remains controversial based on their variable presentation. Treatment options include CSF shunting, endoscopic fenestration, or craniotomy and open fenestration for larger cysts. The complications of these procedures can include hydrocephalus, subdural hematomas, ...
Celikyay Fatih F Gaziosmanpasa University, School of Medicine, Radiology Department, Tokat, Turkey - - 2014
Humeral head cysts are not uncommon in individuals with rotator cuff disorders. The cysts are usually considered an indicator of rotator cuff pathologies; however, they may have different meanings in different regions. To determine the frequency of cysts within and adjacent to the lesser tuberosity and the relationship between these ...
Ghassemi Rezwan R Montreal Neurological Institute, McGill University, Montreal, QC, - - 2014
Children and adolescents with relapsing-remitting multiple sclerosis (RRMS) have a similar T2 lesion burden as adults matched for disease duration. However, it is unknown whether the degree of tissue destruction within lesions is also similar. Persistent reduced T1-weighted signal intensity within lesions indicates loss of tissue integrity. We aimed to ...
Ahmed Aminul I AI Wessex Neurological Centre, University Hospitals Southampton, Southampton, UK; Clinical Neurosciences, University of Southampton, Southampton UK. Electronic address: - - 2014
Pineal region tumours usually present with acute hydrocephalus. Histological diagnosis is paramount since it greatly influences treatment. Endoscopic techniques can combine histological diagnosis with relief of the obstructive hydrocephalus in a single operation. Since pineal region tumours can be heterogeneous, initial biopsies may not represent the most aggressive portion of ...
Zhu Xiaoqing X Department of Gynaecology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, - - 2014
A female with main clinical manifestation of postcoital vaginal bleeding presented to our hospital. The patient was initially diagnosed with cervical carcinoma by the clinicians of the local hospital. However, the biopsy of the cervical lesions revealed chronic inflammation and erosion of cervical mucosa. And the rapid plasma reagin ratio ...
Modaresi Esfeh Jamak J Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, - - 2014
The liver is one of the most commonly involved extrapulmonary sites in sarcoidosis. Hepatic sarcoidosis has a broad range of presentations from scattered, asymptomatic noncaseating granulomas with normal liver enzymes, which are very common in patients with known pulmonary sarcoidosis, to portal hypertension and cirrhosis, which are relatively uncommon. Diagnosis ...
Gibson Tyler C TC Department of Pathology, Woodland Hills Medical Center, Southern California Kaiser Permanente Medical Group, 5601 De Soto Avenue, Woodland Hills, CA, 91365, - - 2014
Nodular fasciitis (NF), very uncommon in the parotid gland, is a benign myofibroblastic proliferation that may be mistaken for other neoplastic proliferations. The mass-like clinical presentation and histologic features result in frequent misclassification, resulting in inappropriate clinical management. There are only a few reported cases in the English literature. Cases ...
da Costa Larissa Bastos Eloy LB Department of Pathology, Faculty of Medical Sciences, University of Campinas - UNICAMP, Campinas, SP, - - 2014
To evaluate p16(INK) (4a) immunoexpression in CIN1 lesions looking for differences between cases that progress to CIN2/3 maintain CIN1 diagnosis, or spontaneously regress. Seventy-four CIN1 biopsies were studied. In the follow-up, a second biopsy was performed and 28.7% showed no lesion (regression), 37.9% maintained CIN1, and 33.4% progressed to CIN2/3. ...
Richards Amanda L AL Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine, Mount Sinai Hospital, New York, New York, - - 2014
Advances in flexible endoscopy with working-channel biopsy forceps have led to excellent visualization of laryngopharyngeal lesions with capability for in-office awake biopsy. Potential benefits include prompt diagnosis without risk of general anesthesia, preoperative counseling, and avoiding an anesthetic should the lesion return benign. We evaluate the accuracy of these biopsies ...
Pospischil Andreas A Institute for Veterinary Pathology, University of Zurich, Winterthurerstrasse 268, CH-8057 Zürich, Switzerland; Collegium Helveticum, University of Zurich and Swiss Federal Institute of Technology, Zurich, Switzerland. Electronic address: - - 2014
In diagnostic and research reports as well as text-books of human and veterinary pathology repeatability, reproducibility, inter- and intra-observer variation are mentioned rarely as a problem in preparing diagnosis from macroscopic and/or microscopic samples and discussed inconsistently. However, optimal care and restoration of health for a patient are dependent on ...
Schmaranzer Florian F Department of Radiology, Medical University Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria, - - 2014
To assess diagnostic performance of traction MR arthrography of the hip in detection and grading of chondral and labral lesions with arthroscopic comparison. Seventy-five MR arthrograms obtained ± traction of 73 consecutive patients (mean age, 34.5 years; range, 14-54 years) who underwent arthroscopy were included. Traction technique included weight-adapted traction (15-23 kg), a ...
Durur-Karakaya Afak A Department of Radiology, Erzurum Regional Training and Research Hospital, Erzurum, - - 2014
In this paper we describe sonoelastography findings for idiopathic granulomatous mastitis (IGM), the clinical and radiological features of which often mimic those of breast carcinoma. In this retrospective study, sonoelastography findings for patients with pathologically proved IGM were studied. Twenty-seven patients with pathologically proved IGM were enrolled in the study. ...
Isaac Andre - - 2014
BackgroundFine needle aspiration (FNA) is the standard of care for the diagnostic work-up of thyroid nodules but despite its proven utility, the non-diagnostic rate for thyroid FNA ranges from 6-36%. A non-diagnostic FNA is problematic for the clinician and patient because it can result in repeated procedures, multiple physician visits, ...
Ferrecchia Christie E CE Office of Laboratory Animal Care, University of California Berkeley, Berkeley, CA, - - 2014
A juvenile rhesus macaque presented with blindness, ataxia, and head tilt. Postmortem gross and microscopic examination, histochemical staining and bacterial culture were performed. Nocardia sp. was identified as the etiologic agent of a primary pneumonia with secondary cerebral abscessation. Nocardiosis should be a differential diagnosis for patients with neurologic disease.
Visvanathan V V Specialist Trainee ENT/Head and Neck Surgery, Southern General Hospital, UK - - 2014
Neurenteric cysts are rare lesions that account for 0.7-1.3% of all spinal cord tumours. We report the first ever case of a neurenteric cyst presenting with stridor and dysphagia. A literature review on the presentation and management of these lesions is also included. A MEDLINE search of articles using the ...
Kuet Mong-Loon ML Department of Otolaryngology-Head and Neck Surgery, Addenbrooke's Hospital, Cambridge University Hospitals, Cambridge, United - - 2014
We present a systematic review of 1,252 lesions published in the past 25 years, the largest to date. We also include our own experience of 41 cases. Our data sources were MEDLINE and Embase databases. A systematic review of the literature (1988-2014) was performed and data on histological diagnosis, presentation, ...
Renaud Mathilde M Département de Neurologie, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, 1 Avenue Molière, 67098, Strasbourg Cedex, - - 2014
Fragile X-associated tremor ataxia syndrome (FXTAS) is caused by FMR1 premutation. The features include ataxia, action tremor and middle cerebellar peduncle (MCP) hyperintensity, the latter being the only major radiological criterion in the diagnosis of definite FXTAS until very recently. The importance of corpus callosum splenium (CCS) hyperintensity was recently ...
Gandrup Karen L KL Departments of Diagnostic - - 2014
Abstract Objective. The aim of this study was to compare split-bolus computed tomography urography (CTU), magnetic resonance urography (MRU) and flexible cystoscopy in patients with macroscopic haematuria regarding the diagnosis of bladder tumours. Materials and methods. In this prospective study, 150 patients underwent CTU, MRU and flexible cystoscopy. Two uroradiologists ...
Akcakaya Mehmet Osman MO Division of Peripheral Nerve Reconstruction, Department of Neurosurgery, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, - - 2014
Background/Aims: Intraneural ganglion cyst is a rare and underrecognized clinical entity in the pediatric population, which may cause pain as well as motor and sensory neurological deficits. This study presents 4 pediatric patients harboring ganglion cysts involving the peroneal and tibial nerves. Methods: Data encompassing pre- and postoperative analyses of ...
Liu Zhuqing Z Department of Medical Oncology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai 200072, P.R. - - 2014
Primary malignant melanoma (MM) of the uterine cervix is a rare neoplasm and the overall prognosis of patients with this disease is poor. Immunohistochemical methods and exclusion of other primary melanoma sites are used to confirm the diagnosis. In the present study, the case of a 65-year-old female patient with ...
Requena Camila Bueno CB Universidade Estadual Paulista Júlio de Mesquita Filho (Unesp), Botucatu, SP, - - 2014
Malignant syphilis is an uncommon manifestation of secondary syphilis, in which necrotic lesions may be associated with systemic signs and symptoms. Generally it occurs in an immunosuppressed patient, mainly HIV-infected, but might be observed on those who have normal immune response. Since there is an exponential increase in the number ...
Sar-Pomian Marta M Department of Dermatology, Medical University of Warsaw, Warsaw, - - 2014
Trichoscopy is becoming increasingly popular in diagnosing hair and scalp diseases. Scalp involvement in pemphigus is common. The scalp may be the first or only site of clinical manifestation of the disease. The aim of this study was to analyze whether trichoscopy may be useful in aiding differential diagnosis of ...
Sarkis L M LM 1University of Sydney Endocrine Surgical Unit, Royal North Shore Hospital, St Leonards 2Department of Anatomical Pathology, Royal North Shore Hospital and Cancer Diagnosis and Pathology Group, Kolling Institute, University of Sydney, Sydney, NSW, - - 2014
Fine needle aspiration biopsy (FNAB) is the initial investigation of choice for thyroid nodules. The Bethesda system, which classifies thyroid FNABs into different categories each linked to a risk of malignancy, has been widely adopted. However, the risk of malignancy implied by each Bethesda category is likely to vary due ...
- - 2014
A shortcut review was carried out to establish whether intraoral ultrasound increased the accuracy of diagnosis and the success of aspiration in adults with suspected peritonsillar abscess (quinsy). Using the reported searches, one paper presented the best evidence to answer the clinical question. The author, date and country of publication, ...
Wu Size S Department of Medical Imaging, Affiliated Hospital of Hainan Medical College, Haikou, - - 2014
The objective of this study was to determine whether there are ultrasound characteristics that can be used to differentiate focal fatty sparing (FFS) from hepatocellular carcinoma and other liver malignancies in liver screening. Data of patients with FFS found at ultrasound were reviewed, 136 patients with FFS were included, and ...
Bernárdez Claudia C Departments of *Dermatology and †Pathology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, - - 2014
: Cutaneous lupus erythematosus may present as an isolated condition or as part of a systemic disease, being acute cutaneous lupus erythematosus, the skin manifestation, more closely related to systemic involvement. The histopathologic findings may show a wide variety of features, which show overlap among different clinical presentations. The exclusive ...
Guet-Revillet Hélène - - 2014
Hidradenitis suppurativa (HS) is a skin disease characterized by recurrent nodules or abscesses and chronic suppurating lesions. In the absence of clear pathophysiology, HS is considered to be an inflammatory disease and has no satisfactory medical treatment. Recently, prolonged antimicrobial treatments were shown to improve or resolve HS lesions. We ...
Gellert Lan L LL From the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New - - 2014
Context .- While biopsies are now increasingly being performed for the diagnosis of renal cortical neoplasms, the influence of the rendered pathological diagnoses on the clinical management is only rarely documented. Objectives .- To report our experience with consecutively performed renal biopsies and the potential impact of the diagnosis on ...
Alves Mônica Ghislaine O MG Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, UNESP - Univ. Estadual Paulista, São José dos Campos, São Paulo, - - 2014
Melanoma of the skin is characterised by a high metastatic potential, but reports of metastasis to the tongue are rare. We report a case of skin melanoma with metastasis to the lymph nodes, tongue and brain. This report highlights the clinical and histological features of oral metastatic melanoma. A 72-year-old ...
Hwang K T KT Department of Orthopaedic Surgery, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, - - 2014
We investigated the incidence of soft-tissue lesions after small head metal-on-metal total hip replacement (MoM THR). Between December 1993 and May 1999, 149 patients (195 hips) underwent primary cementless MoM THR. During the follow-up period, three patients (five THRs) died and eight patients (14 THRs) were lost to follow-up. We ...
Rodríguez-Sánchez Joaquín J Department of Gastroenterology, Hospital General Universitario de Ciudad Real, - - 2014
Oesophagoscopy with biopsy is considered the gold standard for diagnosing and monitoring eosinophilic oesophagitis (EoE). Therefore is important to discover less-invasive diagnostic methods. Cytology specimens were obtained in patients with active EoE (AEoE) (≥15 eos/hpf) and EoE in remission (EoER) (<15 eos/hpf). The samples were assessed by two independent pathologists ...
Pellino Gianluca G aSurgery Unit bGastroenterology Unit, Inflammatory Bowel Diseases Referral Centre, Department of Medical, Surgical, Neurologic, Metabolic and Ageing Sciences, Second University of Naples, Naples, - - 2014
Three patterns of Crohn's disease (CD) have been described. Our aim was to investigate for differences in diagnostic delay between patterns of CD, and differences in treatment outcomes, need for surgery and quality of life (QoL). This is a cross-sectional study. First, the data of CD patients observed at our ...
Skalski Joseph H JH Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, - - 2014
The burden of pleural diseases continues to rise and affects an increasingly complex and aging patient population. As such, thoracentesis is one of the most common procedures performed by respiratory physicians, as pleural fluid analysis can establish the diagnosis of pleural effusions in approximately 75% of the cases. When a ...
Azzopardi Maree M Thoracic Medicine Program, The Prince Charles Hospital, Brisbane, - - 2014
Malignant pleural effusion (MPE) can complicate most malignancies and is a common clinical problem presenting to respiratory and cancer care physicians. Despite its frequent occurrence, current knowledge of MPE remains limited and controversy surrounds almost every aspect in its diagnosis and management. A lack of robust data has led to ...
Poppe Heiko H Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, - - 2014
Primary cutaneous T-cell lymphomas mostly occur in patients of middle and higher age. Their rarity and an oftentimes atypical clinical presentation in childhood as well as the reluctance of taking biopsies in children are reasons for a delayed diagnosis. We report the case of an 11-year-old boy with a 7-year ...
Qureshi Kamran K Division of Hepatology, Department of Medicine, Temple University Health System, Temple University School of Medicine, 3440 North Broad Street, Kresge West, Room 209, Philadelphia, PA 19140, - - 2014
Gastric antral vascular ectasia (GAVE) and portal hypertensive gastropathy (PHG) are important causes of chronic gastrointestinal bleeding. These gastric mucosal lesions are mostly diagnosed on upper endoscopy and can be distinguished based on their appearance or location in the stomach. In some situations, especially in patients with liver cirrhosis and ...
Stone Sarah L SL Departments of *Neurology and †Family Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, - - 2014
Disulfiram toxicity can cause multiple neurologic problems, including a reversible distal sensorimotor axonal polyneuropathy. Although electrodiagnosis and biopsy results have been described in the diagnosis and management of patients with disulfiram associated polyneuropathy, neuromuscular ultrasound findings have not been reported. The authors present a case of electrodiagnostically confirmed axonal polyneuropathy ...
Nagasayi Subramaniam S University Hospital Llandough, Cardiff, UK - - 2014
Giant cell arteritis is a common cause of headache in patients aged more than 50 years. It is an easy diagnosis to make if classical features, ie temporal headache, jaw claudication, visual symptoms, systemic symptoms of fever or weight loss with high erythrocyte sedimentation rate and anemia, are present. However, it ...
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