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Matyja Ewa E Department of Experimental and Clinical Neuropathology, M. Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland; Department of Neurosurgery, M. Sklodowska-Curie Memorial Cancer Centre, Warsaw, - - 2014
Dysembryoplastic neuroepithelial tumors (DNTs) mostly display typical clinical, neuroimaging and histopathological features, but sometimes they reveal heterogeneous or non-specific morphology, which results in diagnostic dilemmas. We present a case of a young adult with longstanding, intractable epilepsy associated with a multinodular cystic lesion in the temporal lobe. The lesion consisted ...
Thompson Bradford B BB Department of Neurology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, 593 Eddy Street, APC-712, Providence, RI, 02903, USA, - - 2014
Transcranial Doppler ultrasound (TCD) has been used as a confirmatory test for the diagnosis of brain death (BD), but may be inaccurate in patients with a skull defect or extraventricular drain (EVD). We report three cases of patients with a skull defect or EVD in whom TCD supported a diagnosis ...
- - 2014
PurposeWe present the clinical, pathologic, and genetic findings of the first reported case of choroidal melanoma that developed a late recurrence and aggressive metastasis to the skull base without evidence of hepatic involvement.MethodsRetrospective chart review and clinicopathologic correlation of ocular and brain tissue, including sequencing of BAP1 for mutations.ResultsA 55-year-old ...
Hayashi Kazunori K Department of Orthopedic Surgery, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, - - 2014
The authors present the case of a 64-year-old woman who was referred for severe sacral pain. She reported that her pain had been longstanding, and had greatly increased after percutaneous fibrin glue placement therapy for a sacral meningeal cyst 2 months earlier at a different hospital. An MRI scan obtained ...
Delamaide Gasper Joy A JA Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI - - 2014
Case Description-An approximately 8-month-old female Miniature Lop rabbit (Oryctolagus cuniculus) was evaluated because of an acute onset of progressive paraparesis. Clinical Findings-The rabbit was ambulatory paraparetic, and results of neurologic examination were consistent with a myelopathy localizing to the T3-L3 spinal cord segments. Evaluation with CT myelography revealed focal extradural ...
Khoshnevisan Alireza A Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, - - 2014
Intramedullary spinal cord metastases are rare .The majority of these metastases reportedly spread from lung cancer in the cervical region; however, they have been seen to arise from a variety of other primary sources. Here, we report what is, to the best of our knowledge, the first known case of ...
Shimony Nir N Department of Neurosurgery, Tel-Aviv Medical Centre, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, - - 2014
Calcified pseudotumours (CPTs) are rarely found in the central nervous system (CNS). Information on supratentorial CPT is limited. We add our experience treating three supratentorial CPTs. Clinical presentation, pathological findings and clinical course are discussed, and a literature review is provided. Between September 2011 and December 2012, three patients (age ...
Baier B B Department of Neurology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany; Department of Neurology, German Center for Vertigo and Balance Disorders-IFBLMU, Ludwig-Maximilians-University, Munich, Germany; Munich Center for Systems Neurology (SyNergy), - - 2014
In functional imaging studies, the insular cortex (IC) has been identified as an essential part of the processing of a whole spectrum of multimodal sensory input. However, there are no lesion studies including a sufficient number of patients, which would reinforce the functional imaging data obtained from healthy subjects. Such ...
Hakim Sofia S a Hospital Clínic, - - 2014
Abstract We describe the first case of meningioangiomatosis identified in a second trimester fetus. A 30-year old pregnant woman was attended at our hospital for a second-trimester ultrasound control. With a diagnosis of partial agenesis of the corpus callosum, parents request the termination of pregnancy. At autopsy, frontal serial sections ...
Burkhardt Jan-Karl JK Department of Neurosurgery, University Hospital of Zurich, Zurich, Switzerland. Electronic address: - - 2014
The study described here examined the feasibility of using high-frequency intra-operative ultrasound (hfioUS) guidance to resect superficial intra-cerebral lesions through a single burr hole. A cohort of 23 consecutive patients with a total of 24 intra-cerebral lesions (9 intra-cerebral metastases, 8 gliomas, 4 infections, 2 lymphomas and 1 cavernoma) were ...
Jain-Ghai Shailly S Department of Medical Genetics, University of Alberta, Stollery Children's Hospital, Edmonton, Canada; - - 2014
Pyridoxine dependent epilepsy (PDE) is caused by mutations in the ALDH7A1 gene encoding α-aminoadipic semialdehyde dehydrogenase. The classic clinical presentation is neonatal seizures responsive only to pyridoxine therapy. White matter abnormalities, corpus callosum agenesis or hypoplasia, megacisterna magna, cortical dysplasia, neuronal heterotopias, intracerebral hemorrhage, and hydrocephalus in neuroimaging have been ...
Bishop Justin A JA Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA, - - 2014
Glandular odontogenic cyst (GOC) is a cyst of the gnathic bones that is characterized by squamous and glandular differentiation. The histopathologic features of GOC overlap considerably with central mucoepidermoid carcinoma (MEC), suggesting that GOC could be a precursor lesion to, or even a low-grade form of, central MEC. Differentiating the ...
Smith Annika A Department of Dermatology, Prince of Wales Hospital, Randwick, NSW, 2031, - - 2014
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory disease of the central nervous system (CNS) that predominantly involves the pons and cerebellum and that improves with immunosuppressive treatment. Only recently described, the etiology is unknown, diagnosis is difficult and long-term neurologic sequelae may occur ...
Hammoud M M Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, 3211 Taubman Center, 1500 E. Medical Center Dr., SPC 5378, Ann Arbor, MI, 48109-5378, - - 2014
Nocardia paucivorans is a recently discovered species that has been shown to have a predilection for CNS involvement in cases of disseminated infection. We present a 50-year-old man with one year of weight loss admitted to the hospital with cough and confusion. Imaging revealed pulmonary and iliopsoas masses as well ...
Lin Tung-Liang TL Department of Statistics, Feng Chia University, Taichung, Taiwan, ROC; Department of Physical Medicine and Rehabilitation, Taichung Veterans General Hospital, Taichung, Taiwan, - - 2014
Lumbar spinal cysts often present with backache and may be accompanied by lower extremity weakness as well as radiation pain if root compression occurs. The treatment regimens include anti-inflammatory drugs, physical therapy, procedures guided by fluoroscopy or computed tomography, and surgery. We report the case of a patient with a ...
Longoni Giulia G From the Neuroimaging Research Unit (G.L., M.F.), Institute of Experimental Neurology; San Raffaele Scientific Institute (G.L., M.F.), Vita-Salute University, Milan, Italy; University of Toronto (G.L., S.B., H.M.B., C.H., J.T.R., E.A.Y.); and The Hospital for Sick Children (G.L., S.B., H.M.B., C.H., J.T.R., E.A.Y.), Toronto, - - 2014
A 10-year-old girl presented with subacute lower limb weakness and gait ataxia. MRI revealed a large multicystic spinal cord lesion with patchy enhancement (figure 1, A-B) and 3 small (<6 mm) periventricular and deep white matter brain lesions. The presence of serum anti-aquaporin-4 immunoglobulin G (AQP4) (ELISA assay) and compatible ...
Radhakrishnan Rupa R Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA, - - 2014
A variety of abnormal imaging findings of the petrous apex are encountered in children. Many petrous apex lesions are identified incidentally while images of the brain or head and neck are being obtained for indications unrelated to the temporal bone. Differential considerations of petrous apex lesions in children include "leave ...
Merbl Yael - - 2014
Two wild adult Nubian ibex (Capra nubiana) were captured and admitted to the Hebrew University Veterinary Teaching Hospital with various neurologic signs, including alerted mentation, head tilt, and pathologic nystagmus. The lesion in the central nervous system was localized to the forebrain in one ibex and to the cerebellum of ...
Toralba Simon S Université de Normandie, Unicaen, UFR de Médecine, Laboratoire d'Histologie, Caen, - - 2014
Cerebral cavernous malformations (CCMs) are described as vascular lesions consisting of endothelial-lined dilated vessels embedded in a connective tissue sheath without intervening parenchyma between them. Their anatomical connections with the normal blood vessels are still enigmatic and the fine three-dimensional (3-D) organization of these vascular lesions remains to be established. ...
Bush Jonathan Willard JW a University of Manitoba, Department of - - 2014
Abstract Atypical teratoid/rhabdoid tumour (AT/RT) is an uncommon, high grade pediatric malignancy of the central nervous system (CNS), which rarely metastasizes outside the CNS (Chang Stage M4). We describe a child with the sole metastasis of an AT/RT to an axillary lymph node and no other site of extra-CNS disease ...
Li Peifeng - - 2014
Meningioangiomatosis (MA) is a rare hamartomatous lesion. Only six cases of cystic MA have been reported in the literature. We present a case of multicystic MA. A 21-year-old woman without any stigmata of neurofibromatosis type 2 presented with intractable seizures since 10 years. Brain magnetic resonance imaging revealed a well-defined, ...
Graves Jennifer J 1Department of Neurology, University of California, San Francisco, CA, - - 2014
Extensive optic nerve demyelinating lesions on magnetic resonance imaging (MRI) in adults could indicate a diagnosis other than multiple sclerosis with worse prognosis such as neuromyelitis optica. We report the frequency of longitudinally extensive lesions in children with first events of optic neuritis. Subjects had brain or orbit MRI within ...
Rekhi Bharat B Department of Pathology, Tata Memorial Centre, Mumbai, Maharashtra, India. Electronic address: - - 2014
Congenital rhabdomyosarcomas (RMSs) are rare tumors with variable clinical presentations. A 2 month-old, term male neonate (37 weeks, 4 days), weighing 3.2kg, born to a 24 year-old primigravida, by simple vaginal delivery presented with multiple erythematous papulonodular lesions over his trunk that progressed to his whole body, on the first ...
Lee Kyung-Hwa KH Departments of - - 2014
Leprosy has a predilection for peripheral nerves and is not considered to involve the CNS. The idea that the CNS is exempt from Mycobacterium leprae bacilli has been suspected from a clinical perspective or CSF study in leprosy patients. However, there has been no direct evidence for CNS involvement by ...
Weidauer S S Department of Neurology, Sankt Katharinen Hospital, Teaching Hospital of the Goethe University, Seckbacher Landstraße 65, 60389, Frankfurt am Main, Germany, - - 2014
The knowledge of characteristic lesion patterns is important in daily practice imaging, as the radiologist increasingly is required to provide precise differential diagnosis despite unspecific clinical symptoms like cognitive impairment and missed elaborated neurological workup. This part II dealing with nonvascular white matter changes of proven cause and diagnostic significance ...
Szewczyk-Bieda M J MJ Clinical Radiology Department, Ninewells Hospital and Medical School, Dundee, UK. Electronic address: - - 2014
A range of disease entities can affect the nasal cavity, often presenting with variable and non-specific symptoms. There is considerable overlap between the clinical and radiological features of neoplastic and non-neoplastic entities. The nasal cavity is often included in routine imaging of the brain, middle ear, skull base, and paranasal ...
Hammond Timothy R TR Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010, USA; Institute for Biomedical Sciences, The George Washington University, Washington, DC 20052, - - 2014
Oligodendrocyte progenitor cells (OPCs) can repair demyelinated lesions by maturing into myelin-producing oligodendrocytes. However, the OPC potential to differentiate can be prevented by inhibitory signals present in the pathological lesion environment. Identification of these signals is essential to promote OPC differentiation and lesion repair. We identified an endogenous inhibitor of ...
Miyazaki Masashi M Department of Orthopaedic Surgery, Faculty of Medicine, Oita University, Oita, - - 2014
Retrospective study. The aim of the present study is to analyze the prevalence and distribution of cervical and thoracic compressive lesions of the spinal cord in lumbar degenerative disease, using whole-spine postmyelographic computed tomography. Of the various complications resulting from spinal surgery, unexpected neurological deterioration is the most undesired. There ...
Aronica Eleonora E Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands, - - 2014
Structural abnormalities of the brain are increasingly recognized in patients with neurodevelopmental delay and intractable focal epilepsies. The access to clinically well-characterized neurosurgical material has provided a unique opportunity to better define the neuropathological, neurochemical, and molecular features of epilepsy-associated focal developmental lesions. These studies help to further understand the ...
Hajj-Ali Rula A RA Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Center for Vasculitis Care and Research, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: - - 2014
Central nervous system vasculitis is one of the foremost diagnostic challenges in rheumatology. It results in inflammation and destruction of the vasculature within the CNS. When vasculitis is confined to brain, meninges or spinal cord, it is referred to as primary angiitis of the CNS. Secondary CNS vasculitis occurs in ...
Yamasaki Kouji K Department of Neurosurgery, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan, - - 2014
Primary diffuse leptomeningeal gliomatosis (PDLG) is a rare and fatal disease characterized by diffuse infiltration of the leptomeninges by neoplastic glial cells without evidence of tumor in the brain parenchyma or spinal cord. We report a 60-year-old man with PDLG. He suffered transient right hemiparesis and generalized seizures. MRI showed ...
Sabatino Giovanni G Institute of Neurosurgery, Catholic University of Rome , Rome , - - 2014
A 52-year-old woman displayed a brain-MRI depicting a left lateral ventricle mass, associated with cystic component, extending controlaterally. Histological examination revealed neuronal differentiation with neurocytes and small ganglionic cells and the tumour was graded as a ganglioneurocytoma. We report the first case of a cystic ganglioneurocytoma with an intraventricular location.
Chuang Ming-Tsung MT Department of Diagnostic Radiology, National Cheng Kung University Hospital, No. 138 Sheng-Li Rd, Tainan, 704, - - 2014
Internuclear ophthalmoplegia is caused by a lesion; stroke, multiple sclerosis, brain metastases, or trauma may produce lesions of the medial longitudinal fasciculus (MLF). Imaging techniques, such as DWI, can help identify the site of the lesion in order to speed diagnosis and lead to appropriate treatment. Over an 8-month period, ...
Neutel Dulce - - 2014
Introduction Differential diagnosis of acute/subacute intrinsic spinal cord lesions can be challenging. In addition, intramedullary neoplasms typically show gadolinium enhancement, mass effect, and cord expansion. Case report We report a patient with spinal cord and brain stem lesions resembling multifocal myelitis. Magnetic resonance imaging showed no spinal cord enlargement or ...
Li Gang - - 2014
It is generally believed that malignant gliomas never metastasize outside the central nervous system (CNS). However, the notion that oligodendrogliomas (OGDs) cells cannot spread outside CNS is being challenged. We described in detail the clinical story of one patient with anaplastic OGD, which metastasized to lymph nodes, bone marrowand bones ...
Yan Jianhua J From the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, - - 2014
The purpose of this study was to report a rare case of neurofibromatosis type 2 (NF2) with extracranial orbital meningioma extending into the frontal and ethmoidal sinuses. This is clinical report of a 17-year-old male patient with NF2. Results of an ocular examination, computed tomography scan, and pathological findings of ...
Alomari Ahmed A Neuropathology Program, Department of Pathology, Yale University School of Medicine, 416A Lauder Hall, 310 Cedar Street, New Haven, CT, 06520, - - 2014
Progressively enlarging encephalopathic changes are now well-documented effects of gamma knife radiosurgery (GKRS) occurring ~3-30 months after treatment of both benign and malignant brain lesions. These changes can be variably associated with inflammatory demyelination and necrosis and/or recurrent tumor. While radiographic differentiation between encephalopathic changes and recurrent tumor is of high ...
Seghier Mohamed L ML From the Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, - - 2014
Lesioned brains of patients with stroke may change through the course of recovery; however, little is known about their evolution in the chronic phase. Here, we aimed to quantify the extent of lesion volume change and brain atrophy in the chronic poststroke brain using magnetic resonance imaging. Optimized T1-weighted scans ...
Choi Jong-Il JI Department of Neurosurgery, Korea University Ansan Hospital, Ansan, South - - 2014
The purpose of this study was to investigate efficient ways to diagnose and predict clinical outcomes for childhood traumatic brain injury. Hemorrhagic signal intensities in nine brain regions were observed using axial fluid-attenuated inversion recovery (FLAIR) and susceptibility-weighted imaging (SWI). After having divided the subjects into mild presentation (GCS 14-15) ...
Anthony Daniel C DC Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. Electronic address: - - 2014
We examined the effect of fingolimod (0.1 and 0.3 mg/kg/day orally) on blood-brain barrier (BBB) function, demyelination and leukocyte recruitment at different stages of the focal delayed-type hypersensitivity (DTH) multiple sclerosis model in Lewis rats using immunohistochemistry and gadolinium (Gd)-enhancing magnetic resonance imaging (MRI). During DTH lesion formation, fingolimod reduced BBB ...
Kipfer Stefan S Department of Internal Medicine and Neurology, Kantonsspital Olten, - - 2014
Predilection sites for infratentorial multiple sclerosis lesions are well known and frequently involve the fasciculus longitudinalis medialis leading to classical internuclear ophthalmoplegia. We report a very rare oculomotor disorder due to a demyelinating central nervous system (CNS) lesion in the medial part of the lower pontine tegmentum. A 36-year-old man ...
Hands James R JR Centre for Materials Science, Division of Chemistry, JB Firth Building, University of Central Lancashire, Preston, PR1 2HE, - - 2014
Gliomas are the most frequent primary brain tumours in adults with over 9,000 people diagnosed each year in the UK. A rapid, reagent-free and cost-effective diagnostic regime using serum spectroscopy would allow for rapid diagnostic results and for swift treatment planning and monitoring within the clinical environment. We report the ...
Schier Lindsey A LA Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL - - 2014
Gustatory cortex (GC), an assemblage of taste-responsive neurons in insular cortex, is widely regarded as integral to conditioned taste aversion (CTA) retention, a link that has been primarily established using lesion approaches in rats. In contrast to this prevailing view, we found that even the most complete bilateral damage to ...
Taylor Amanda A Small Animal Clinical Sciences, Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, - - 2014
A 12-year-old mixed breed dog was presented for evaluation of progressive paraparesis and ataxia. Magnetic resonance (MR) imaging was performed and identified multifocal intradural spinal cord mass lesions. The lesions were hyperintense in T2-weighted sequences, isointense to mildly hyperintense in T1-weighted sequences with strong contrast enhancement of the intradural lesions ...
Kim Seok-Won - - 2014
Intraspinal neurocysticercosis is an uncommon manifestation that may present as an isolated lesion. Furthermore, acute hydrocephalus caused by isolated intraspinal neurocysticercosis without concomitant cerebral involvement is extremely rare. A 64-year-old man presented with a history of severe headache, an unsteady gait, and occasional urinary incontinence. Magnetic resonance imaging of the ...
Dammann Philipp P Department of Neurosurgery, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, - - 2014
The objective of this study was to analyse our initial experience using an interdisciplinary angio suite approach to neurosurgical treatment of complex neurovascular lesions and expound technical feasibility and possible applications. Six out of 451 patients with cranial or spinal neurovascular lesions were surgically treated in the angio suite (biplane ...
Ajlan Abdulrazag M AM Department of Neurosurgery, Stanford University, Stanford, California, United States of - - 2014
Colloid cysts, benign outgrowths from the roof of the third ventricle, warrant resection when they become symptomatic. Historically, this has been performed by craniotomy and a transcortical or a transcallosal approach that employs a pair of fixed blade retractors and an operating microscope. Less invasive endoscopic techniques have employed rigid ...
Sakuta Kenichi K Department of Neurology, The Jikei University School of - - 2014
A 64-year-old man had transverse myelopathy that rapidly progressed without pain over the course of 1 day. The cerebrospinal fluid interleukin-6 (CSF IL-6) level was extremely high (1,120 pg/dl). Spinal cord magnetic resonance imaging (MRI) showed a longitudinal extensive lesion extending from Th8 to the conus medullaris. Despite treatment with ...
Sakurai Katsunobu K Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, - - 2014
Abstract A 61-year-old man presented to our hospital with hypercalcemia and elevated C reactive protein (CRP). Evaluation revealed renal cell carcinoma (RCC) with metastasis to lung, bone, and brain. He underwent partial resection of the right kidney and a left nephrectomy. Histopathologic findings of resected tumors were consistent with clear ...
Giorli Elisa E Department of Clinical and Experimental Medicine, Pisa University, Medical School, Pisa, - - 2014
Mycosis Fungoides (MF) is a rare malignant T-cell lymphoma, involving mainly the skin. In 50%-75% of cases, it can involve organs other than skin, with a 11%-14% Central Nervous System involvement (CNS). A 82-year-old woman presented to our Department with a 15-years history of MF with skin lesions. Neurological examination ...
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