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Cheah Alison L AL Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, United - - 2014
Recurrent NAB2-STAT6 gene fusions have recently been identified in solitary fibrous tumour by next generation sequencing. Our aim was to examine the sensitivity and specificity of STAT6 immunohistochemistry for solitary fibrous tumour versus other morphologically similar soft tissue tumours. STAT6 expression was evaluated in 54 solitary fibrous tumours of various ...
Yang Dennis D From the Division of Gastroenterology, University of Florida, Gainesville, - - 2014
The aim of this study was to evaluate predictors of malignancy in pancreatic lesions with suspicious or indeterminate endoscopic ultrasound fine-needle aspiration (EUS-FNA) cytology. Suspicious/indeterminate EUS-FNA cytology was identified from our database. Stable imaging, benign pathology, or survival for 12 months after EUS-FNA was considered benign. Diagnosis of malignancy was ...
Fremlin G A GA Bristol Dermatology Centre, University Hospitals Bristol, Bristol, Avon, - - 2014
Provisional clinical diagnosis is the first step in planning skin surgery. Different clinical priorities are given to basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). Discriminating between SCC and BCC can be difficult. The rate of misdiagnosis of SCC as BCC is reported as 5.7-87.6%, and ...
Muller Karra K From the Department of Pathology, UC San Diego, San Diego (Dr Muller), and the Department of Pathology, UC San Diego, La Jolla (Dr Lin), - - 2014
The pathology of granulomatosis with polyangiitis (GPA), formerly Wegener granulomatosis, typically features a granulomatous and sometimes necrotizing vasculitis targeting the respiratory tract and kidneys. However, orbital involvement occurs in up to 60% of patients and is frequently the first or only clinical presentation in patients with systemic or limited forms ...
Gwili Noha N - - 2014
Abstract Abstract Assessment of lymphadenopathy in children represents a diagnostic challenge because of the extensive differential diagnoses including reactive and malignant conditions. Knowledge of the etiologic pattern of lymphadenopathy in a given geographical region is essential for making a confident diagnosis or suspecting a disease. Hence, the present study was ...
Lourenço Dmr D Pediatric Rheumatology Unit, Pediatric Department, Faculdade de Medicina da Universidade São Paulo, São Paulo, - - 2014
Bullous systemic lupus erythematosus has rarely been described in pediatric lupus population and the real prevalence of childhood-onset bullous systemic lupus erythematosus has not been reported. From January 1983 to November 2013, 303 childhood-onset SLE (c-SLE) patients were followed at the Pediatric Rheumatology Unit of the Childreńs Institute of Hospital ...
Chen Dongying D Department of Rheumatology and Clinical Immunology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. - - 2014
We aimed to explore the incidence of malignancy in dermatomyositis and assess the potential risk factors of occurrence of malignancy in DM from southern China. A retrospective cohort study of patients admitted in the 1st affiliated university hospital between 2003 and 2012 was performed. Demographic information, clinical symptoms, laboratory findings, ...
Horst C C Department of Dermatology, The Whittington Hospital, London, - - 2014
Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon, idiopathic disease that manifests as dermal or subcutaneous red or brown papules or nodules, most commonly on the head and neck. Histologically, ALHE is characterized by vascular proliferation with epithelioid endothelial cells with surrounding lymphocytic and eosinophilic infiltrate. There may be an ...
Konstantinidis Ioannis T IT Ioannis T Konstantinidis, Jennifer A Wargo, Carlos Fernandez-del Castillo, Keith D Lillemoe, Andrew L Warshaw, Cristina R Ferrone, Departments of Surgery, Massachusetts General Hospital, Boston, MA 02114, United - - 2014
To identify their diagnostic and prognostic clinical characteristics in a large series. Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at Massachusetts General Hospital. Twelve patients were identified between 1/1/1997 and 8/1/2007. Their median age was 55.5 years (range ...
Cantara Silvia S Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, - - 2014
Context: MicroRNA are non-protein encoding RNAs that regulate gene expression and enable the distinction of benign from malignant tissues in human cancers. Objective: We investigated the role of miRNA circulating in the blood for the differential diagnosis of thyroid nodules. Methods: MicroRNAs profiling was assessed by TaqMan® Array Human MicroRNA ...
Phelps Paul O PO Department of Ophthalmology, John H. Stroger, Jr., Hospital of Cook County , Chicago, IL , USA - - 2014
Abstract A 19 year-old African American man presented to our clinic for a second opinion about a right upper eyelid mass which had been recalcitrant to treatment for nonspecific orbital inflammation by an outside facility. Examination for systemic causes of the patients eyelid lesion led to a diagnosis of acute ...
Bémer Pascale P CHU Nantes, Laboratoire de Bactériologie, Nantes, France - - 2014
There is no gold standard for the diagnosis of prosthetic-joint-infection (PJI). The contribution of 16S rDNA PCR sequencing on a routine basis remains to be defined. We performed a prospective multicenter study to assess the contribution of 16S rDNA in PJI diagnosis. Over a 2-year period, all patients suspected of ...
Edwards Laura J LJ Centre for Disease Control, Department of Health, Darwin, Northern Territory, Australia - - 2014
A case of fevers, sepsis and chest lesions on CT scan following burns to the feet in an Indigenous man in northern Australia is described. Sputum polymerase chain reaction testing revealed Mycobacterium leprae and and fine needle aspirate of the chest lesions demonstrated Cryptococcus co-infection.
Moriyama M M Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan. Electronic address: - - 2014
IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS) is characterized by serum IgG4 elevation and the infiltration of IgG4-positive plasma cells in glandular tissues. For definitive diagnosis of IgG4-DS, biopsies of local lesions are recommended to exclude Sjögren's syndrome (SS), malignant tumours, and similar disorders. In this study, we examined the diagnostic utility ...
Lei Frank - - 2014
A study of the whole spectrum of biopsied head and neck (HN) diseases in Taiwan has not yet been performed. Therefore, the current study aimed to provide updated information about HN lesions in a cohort of referral Taiwanese patients for histopathological examination. HN lesions (2000-2011) in patients with records of ...
Pommelet V V Institut Pasteur, Emerging Diseases Epidemiology Unit, Paris, - - 2014
 Mycobacterium ulcerans is known to cause Buruli ulcer (BU), a necrotising skin disease leading to extensive cutaneous and subcutaneous destruction and functional limitations. However, M. ulcerans infections are not limited to skin, and osteomyelitis, yet poorly described in the literature, occurs in numerous young patients in Africa.  In a retrospective ...
Fening Katherine K *Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL; †Department of Pathology, University of Michigan, Ann Arbor, MI; and ‡Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, - - 2014
: We present a case of a 6-year-old girl with recessive dystrophic epidermolysis bullosa (EB) who presented with a large pigmented lesion clinically concerning for melanoma. After histological examination and fluorescent in situ hybridization analysis, diagnosis of EB nevus was performed. EB nevi are benign melanocytic neoplasms with histological findings ...
Venegas Eva E Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen del Rocío, Sevilla, España. Electronic address: - - 2014
Craniopharyngiomas are rare, locally aggressive epithelial tumors usually located in the sellar and suprasellar region. Diagnosis of craniopharyngioma is usually suggested by clinical and radiological findings that should be confirmed histologically. Surgery is the treatment of choice for most patients. The goal of surgery is to relieve compressive symptoms and ...
González Saldaña Napoleón - - 2014
Pulmonary tuberculosis (PTB) is an infectious disease that involves the lungs and can be lethal in many cases. Tuberculosis (TB) in children represents 5 to 20% of the total TB cases. However, there are few updated information on pediatric TB, reason why the objective of the present study is to ...
Ozeki Naoki N Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, - - 2014
With the recent improvements in the diagnostic accuracy of radiographic modalities, it might be an option to perform therapeutic surgery without a definitive diagnosis for selected patients with suspected lung cancer based on the findings of diagnostic imaging. Between April 2008 and December 2012, all nodules without a definitive diagnosis ...
Ajuz Natasha C NC Department of Endodontics and Immunohistochemistry Laboratory, Faculty of Dentistry, Estácio de Sá University, Rio de Janeiro, RJ, - - 2014
Interleukin (IL)-17 expression has been detected in apical periodontitis lesions, but its role in the disease process remains unclear. The present study compared the expression of IL-17 in periradicular cysts and granulomas and evaluated the association of this cytokine with clinical and radiographic findings. Apical periodontitis lesions (18 cysts and ...
Carlson Matthew L ML *Departments of Otolaryngology-Head and Neck Surgery, †Neurologic Surgery, ‡Radiology, and §Neurology, Mayo Clinic School of Medicine, Rochester, MN, U.S.A.; and ∥Departments of Otolaryngology-Head and Neck Surgery, ¶Neurology, Vanderbilt University Medical Center, Nashville, TN, - - 2014
Neurosarcoidosis is a rare granulomatous disease that can result in cranial neuropathy, chronic meningitis, and intracranial granuloma formation. Meningeal involvement may cause focal nodular enhancement that can simulate common cranial base tumors. The objective of the current study is to further define the clinical features of neurosarcoidosis in a large ...
Naresh Kikkeri N KN Departments of Histopathology, Imperial College Healthcare NHS Trust and Imperial College, London, - - 2014
To highlight the likelihood of occurrence of IgG4 expression in mucosa-associated lymphoid tissue lymphomas (MALT lymphoma) at certain sites, and to suggest a possible link with IgG4-related disease. A case of MALT lymphoma with bilateral lacrimal gland involvement is presented. Lesional cells expressed IgG4, and the patient also presented with ...
Lim Byung Chan BC Pediatric Clinical Neuroscience - - 2014
Brainstem glioma is a highly devastating disease, and any mass-like lesion in the brainstem can raise suspicion of this diagnosis. However, other inflammatory, demyelinating, or degenerative diseases can mimic brainstem glioma in clinical presentation and imaging features. Therefore, diagnosis based solely on imaging is often insufficient for brainstem lesions and ...
Bhojwani Nicholas N University Hospitals Case Medical Center, Department of Radiology, 11100 Euclid Ave, Cleveland, OH 44106. - - 2014
Histoplasma capsulatum can rarely affect the trachea. We report the case of a 68-year-old female with rheumatoid arthritis on immunosuppressive therapy who presented with fevers, worsening shortness of breath, nonproductive cough, and subjective throat hoarseness and fullness. Chest CT demonstrated no tracheal findings. Bronchoscopy found mucosal irregularity, nodularity, and vesicular ...
Fiallo Paolo P Unit of Social Dermatology and National Reference Center for Hansen's Disease, National Institute for Cancer Research, Genoa, - - 2014
Tuberculides are skin lesions caused by the hematogeneous dissemination of Mycobacterium tuberculosis. Bacilli are rapidly destroyed in the skin and are thus neither visible histologically nor identifiable by culture. Diagnosis depends on previous knowledge of systemic and/or cutaneous tuberculosis. Lichen scrofulosorum (LS), the most uncommon variant of tuberculid, is usually ...
Llamas-Velasco Mar M Departments of *Pathology, †Dermatology, and ‡Hematology, Hospital Universitario De "La Princesa", Madrid, Spain; and §Kempf und Pfaltz, University Hospital Zürich, Zurich, - - 2014
: Cutaneous manifestation as the first sign of Hodgkin lymphoma (HL) is very rare and diagnostically challenging; especially, because the clinical presentation of specific skin involvement by HL is polymorphous. We present a 44-year-old man with erythematous indurate papules and plaques in the right forearm and arm where skin biopsy ...
Sato Tadashi T Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, - - 2014
Pleural mesothelioma is an aggressive tumor, commonly caused by exposure to asbestos. The prognosis of mesothelioma remains disappointing despite multimodal treatment. We reported previously that N-ERC/mesothelin could be a useful biomarker for the early diagnosis of pleural mesothelioma and developed an enzyme-linked immunosorbent assay (ELISA) system for its detection. However, ...
Xiang Dapeng D Department of General Surgery, Second Affiliated Hospital School of Medicine, Zhejiang University, Hangzhou, - - 2014
To examine the value of CEUS as a non-invasive tool in detecting lateral neck metastasis (LNM) and the enhancement patterns of malignant lymph nodes (LN) for thyroid cancer patients. Eighty-two consecutive patients, who underwent both preoperative non-enhanced US and CEUS examinations, were retrospectively reviewed. All patients underwent lateral neck dissection ...
Kanno Kyoko K Department of Dermatology, Asahikawa Medical University, Asahikawa, - - 2014
We report a 38-year-old male patient who presented with cutaneous lesions mimicking widespread discoid lupus erythematosus with high-grade fever, arthralgia and lymphadenopathy. Additional lymph node and skin biopsies, however, revealed karyorrhectic debris without neutrophils and numerous CD68-positive cells, a characteristic finding of Kikuchi's disease (KD). Comparing skin biopsies on different ...
Onoda Naoyoshi - - 2014
Reactive lymphoid hyperplasia is a benign nodular lesion characterized by marked proliferation of non-neoplastic, polyclonal lymphocytes forming follicles. The lesion is found in various organs such as skin, orbit, lung, gastrointestinal tract, and liver. However, reactive lymphoid hyperplasia in the thyroid gland is extremely rare. Here, we present an interesting ...
Arcolia Vanessa - - 2014
The preoperative characterization of thyroid nodules is a challenge for the clinicians. Fine-needle aspiration (FNA) is the commonly used pre-operative technique for diagnosis of malignant thyroid tumor. However, many benign lesions, with indeterminate diagnosis following FNA, are referred to surgery. There is an urgent need to identify biomarkers that could ...
Destelı Güldeniz Aksan GA Department of Obstetrics and Gynecology, Başkent University, Faculty of Medicine, İSTANBUL, - - 2014
Objective: Many epidemiological studies have shown that human papillomavirus related infections play a major role in cervical preinvasive and invasive lesions. ASCUS (atypical cells of undetermined significance) observed in about 4-5% of all cervical cytology specimens. We searched for the presence of HPV with immunohistochemical methods in the biopsy material ...
Moore S Arthur SA Department of Neurology, Critical Care, Mayo Clinic, Rochester, MN 55902, - - 2014
Subarachnoid hemorrhage (SAH) is a devastating neurologic condition with a high mortality and long term neurological morbidity in 50% of survivors. In addition, SAH commonly affects young patients causing substantial loss of productive life years and resulting in significant long term healthcare costs. Early recognition of the signs and symptoms ...
Ganesan Suguna S Department of Pediatrics, Division of Cardiology (S.G., M.M.B., N.H.S., A.J.M.-G.), and Fetal Treatment Center (A.J.M.-G.), University of California, San Francisco, Benioff Children's Hospital, San Francisco, California - - 2014
Optimal perinatal management of total anomalous pulmonary venous return (TAPVR) involves timely identification followed by surgical correction. Antenatal diagnosis, however, has long been a challenge. We aimed to identify consistent prenatal sonographic features in this condition in a large cohort in whom the diagnosis was made antenatally and confirmed postnatally. ...
Che Yi-Qun YQ Clinical Laboratory, Cancer Institute and Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, P.R. - - 2014
Hepatoid adenocarcinoma of the lung (HAL) is a rare type of lung cancer. Its diagnosis and treatment may be difficult due to the varied presentation; however, immunohistochemical analysis facilitates the diagnosis. The present study presents a case of HAL. The patient was a 48-year-old male who presented with a primary ...
Jiao Guohui G Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. - - 2014
The gastrointestinal tract is the most common location for primary extranodal non-Hodgkin lymphoma (NHL) with cases less commonly found in the intestine. The majority of primary intestinal B-cell lymphomas are exophytic, whereas enteropathy-associated T-cell lymphomas present predominantly as thickened plaques, ulcers or strictures. Crohn's disease (CD) is a chronic inflammatory ...
Paganoni Sabrina S Department of Neurology, Harvard Medical School, Neurological Clinical Research Institute (NCRI), Massachusetts General Hospital , Boston, Massachusetts , - - 2014
The objective of this study was to characterize the diagnostic timelines and their predictors in people with amyotrophic lateral sclerosis (ALS). Patients were identified through ALS billing codes. Time from presenting symptom to first doctor visit, first doctor visit to suspected ALS diagnosis, suspected to confirmed ALS diagnosis, and presenting ...
Goyal Abhishek A *Department of Pulmonary Medicine, All India Institute of Medical Sciences (AIIMS), Bhopal Departments of †Pulmonary Medicine ‡Cytology §Histopathology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, - - 2014
The exact position of routine bronchoscopic sampling techniques in diagnostic workup of sarcoidosis is often debated. Herein, we ascertain the role of transbronchial needle aspiration (TBNA), endobronchial ultrasound-guided TBNA (EBUS-TBNA), transbronchial lung biopsy (TBLB), and endobronchial biopsy (EBB) in diagnosis of sarcoidosis. Consecutive patients with suspected sarcoidosis who underwent fiberoptic ...
Rubio Carlos A CA Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm 17176, Sweden. Electronic address: - - 2014
Patients with inflammatory bowel disease may develop dysplasia in the cryptal epithelium, polypoid neoplasias, and nonpolypoid (flat) adenomas, lesions at risk to proceed to colorectal carcinoma. The onset of invasion in nonpolypoid adenomas may occur without changes in the shape or the size of the lesion. In experimental animals, some ...
Newton Jamie A JA School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, - - 2014
Hodgkin's like lymphoma is a slow growing neoplasm, usually affecting the lymph nodes of the head and neck, which has been sporadically described in veterinary patients. This report describes the clinical and histopathological features in a 9-year-old male neutered Siamese cat that presented with a 6 week history of mid-dorso ...
Ise M M Division of Dermatology, Hiratsuka City Hospital, Hiratsuka, - - 2014
IgG4-related disease (IgG4-RD) is a newly recognized condition that is characterized by raised levels of serum IgG4, tissue infiltration of IgG4-positive plasma cells and presence of fibrosis. It affects multiple organs, including the pancreas, bile duct, and lacrimal and salivary glands. Skin lesions have rarely been reported, and those that ...
Kim Tae-Yong TY Departments of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, - - 2014
A newly isolated mediastinal lymph node (LN) or a small pulmonary nodule, which appears during breast cancer surveillance, may pose a diagnostic dilemma with regard to malignancy. We conducted this study to determine which clinical factors were useful for the differentiation of malignant lesions from benign lesions under these circumstances. ...
Baron Luigi L Unit of Pathology, S. Leonardo Hospital, Castellammare di Stabia, Naples, - - 2014
Anisakidosis is a human zoonotic disease caused by the ingestion of raw or undercooked or not adequately salted, pickled, or smoked fish containing larval nematodes of the Anisakis species. The incidence of this infection is higher in geographical zones with traditional consumption of raw fish. However, in the last years, ...
Fabre Andréa Buosi AB Faculdade Evangélica do Paraná, Curitiba, PR, - - 2014
Intravascular papillary endothelial hyperplasia is a benign vascular lesion caused by proliferation of endothelium. It is reactive to thrombotic or inflammatory stimuli in the vessel wall.We report the case of a 14-yearold male patient with a violet-colored erythematous tumoral lesion of progressive growth in the occipital region. The diagnosis of ...
Maquiné Gustavo Ávila GÁ Alfredo da Matta Foundation, Manaus, AM, - - 2014
We report the case of a 81-year-old female patient who had a two-year history of violet-colored erythematous tumors on both legs. Histopathological and immunohistochemical examinations confirmed the diagnosis of primary cutaneous large B-cell lymphoma, leg type. This rare, cutaneous lymphoma affects predominantly elderly females. Clinically, patients present with tumoral lesions ...
Oliveira Marcos C B MC Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, - - 2014
Recent studies have suggested a possible relationship between temporal lobe epilepsy with mesial temporal sclerosis (MTS) and neurocysticercosis (NC). We performed a case-control study to evaluate the association of NC and MTS. We randomly selected patients with different epilepsy types, including: MTS, primary generalized epilepsy (PGE) and focal symptomatic epilepsy ...
Rather Parvaiz Anwar PA Department of Dermatology, Venereology and Leprosy, Government Medical College, Srinagar, Jammu and Kashmir, - - 2014
Lichen myxoedematosus (LM), a form of primary cutaneous mucinosis, may present either as localized less severe form called papular mucinosis or diffuse more severe form called scleromyxoedema. The diffuse form is almost always associated with monoclonal gammopathy, whereas localized form is not. We report an atypical case of localized form ...
Buch Archana C AC Department of Pathology, Padmashree Dr. D.Y. Patil Medical College, Pimpri, Pune, - - 2014
Autoimmune blistering diseases are a group of bullous disorders characterized by pathogenic antibodies directed at the target antigens, which are components of the desmosomes or adhesion complex at the dermoepidermal junction. Direct immunofluorescence (DIF) is invaluable in the diagnosis of these lesions. The aim of this study was to evaluate ...
Fernandes Joycelin J Department of Dermatology, Venereology and Leprology, Goa Medical College, Bambolim, Goa, - - 2014
Bullous pemphigoid (BP) is an autoimmune sub-epidermal blistering disorder of the skin. The association of BP with internal malignancy has always been a matter of debate with no consensus reached despite many published case reports and clinical trials. However, we report a hitherto unreported association of BP with squamous cell ...
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