Search Results
Results 1 - 50 of 1097
1 2 3 4 5 6 7 8 9 10 >
Chen Yumay - - 2014
BackgroundNeks, mammalian orthologs of the fungal protein kinase never-in-mitosis A, have been implicated in the pathogenesis of polycystic kidney disease. Among them, Nek1 is the primary protein inactivated in kat2J mouse models of PKD.ResultWe report the expression pattern of Nek1 and characterize the renal cysts that develop in kat2J mice. ...
Edwards Andrew Kenneth AK Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada, K7L - - 2014
Endometriosis is a chronic painful gynecological condition characterized by adherence and growth of endometrium outside of the uterine cavity. Neovascularization is essential to the developing endometriosis lesion to support its growth. Synuclein-γ (SNCG), a protein implicated in cellular proliferation, is associated with a broad range of malignancies as well as ...
Arpaci Rabia Bozdo─čan RB From the Departments of *Pathology, and †Otorhinolaryngology, Mersin University Medical School, Mersin, - - 2014
Hyalinizing clear cell carcinoma is a low-grade malignant epithelial neoplasm of the salivary glands. The tumor has epithelial cells and lacks myoepithelial cells. Necrotizing sialometaplasia is a benign, self-limiting lesion of the salivary glands. The clinical and histologic features mimic those of mucoepidermoid carcinoma or squamous cell carcinoma.The importance of ...
Santos Nuno P NP Veterinary Sciences Department, University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal; Veterinary Science Department, Veterinary and Animal Science Research Centre (CECAV), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, - - 2014
Hepatocellular carcinoma (HCC) is a common malignancy with poor clinical outcome, whose histogenesis is the subject of intense debate. Specifically, expression of cytokeratins (CKs) 7 and 19, associated with aggressive biological behaviour, is proposed to reflect a possible progenitor cell origin or tumour dedifferentiation towards a primitive phenotype. This work ...
Nair Bindu J BJ Department of Oral Pathology and Microbiology, PMS College of Dental Science and Research , Kerala, - - 2014
Myoepitheliomas account for less than 1% of all salivary gland tumors and mostly occur in the parotid gland and palate. A 58-year old male patient reported to the Outpatient Department of PMS College of Dental Science and Research (Kerala, India) with a slow growing painless swelling on the palate for ...
Kurashige Yuta Y Department of Dermatology, Hachioji Medical Center of Tokyo Medical University, Tokyo, - - 2014
Hidradenoma papilliferum (HP) is a benign adnexal neoplasm which preferentially develops in the anogenital region of women. Although the origin of HP was previously thought to be an apocrine sweat gland, recent studies have suggested that it may derive from the anogenital mammary-like gland (MLG). In this paper, we present ...
El Khoury Jinane J Department of Dermatology, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El-Solh, Beirut, 1107 2020, - - 2014
Fibroblast-activation protein (FAP) is a key protein that is characteristically expressed by carcinoma-associated fibroblasts (CAFs). It has been shown to be expressed in CAFs of 90 % of internal epithelial cancers as well as cutaneous epithelial malignancies. We have recently shown that this marker is useful in differentiating between morpheaform/infiltrative BCC ...
Yuajit Chaowalit C Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand; Department of Internal Medicine, Genetic, Yale University School of Medicine, New Haven, Connecticut, - - 2014
Cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) is associated with cAMP-activated proliferation of cyst-lining epithelial cells and transepithelial fluid secretion into the cyst lumen via cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel leading to renal failure for which no effective treatment is currently available. We previously reported ...
Cruz-Monserrate Zobeida Z Department of Cancer Biology, University of Texas, M. D. Anderson Cancer Center, Houston, TX, - - 2014
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the USA, accounting for ~40,000 deaths annually. The dismal prognosis for PDAC is largely due to its late diagnosis. Currently, the most sensitive diagnosis of PDAC requires invasive procedures, such as endoscopic ultrasonography, which has inherent risks ...
Fujii Etsuko E Research Division, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura, Kanagawa 247-8530, - - 2014
Human tumor tissue line models established in the severely immunodeficient NOD.Cg-Prkdc(scid) Il2rg(tm1Sug)/Jic (NOD/Shi-scid, IL-2Rγ(null) or NOG) mouse are important tools for oncology research. During the establishment process, a lymphoproliferative lesion (LPL) that replaces the original tumor cells in the site of transplantation occurs. In the present study, we studied the ...
Komoike Nobuhiko - - 2013
Detection of dysplastic lesions in mouse colonic tissue was investigated by accumulation of photosensitizer protoporphyrin IX (PpIX) induced by oral administration of 5-aminolevulinic acid (5-ALA), a precursor of PplX. Inflammatory oncogenesis was induced in C57BL/6J-Apc(Min) (Apc(Min/+)) mouse by oral administration of dextran sodium sulfate (DSS). After oral administration of 5-ALA, ...
Baron S - - 2013
Pleomorphic adenoma is the most common benign tumour of the salivary glands. The major salivary glands are most commonly involved, or more rarely accessory salivary glands, especially the oral cavity. Other locations, such as the nasal cavity, paranasal sinuses or upper aerodigestive tract, are exceptional. A 26-year-old female presented with ...
Popp Nicholas N Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Dr., 10/10N103, NIH/NEI, Bethesda, MD, 20892-1857, - - 2013
Although the mouse has no macula leutea, its neuroretina and retinal pigment epithelium (RPE) can develop lesions mimicking certain features of age-related macular degeneration (AMD). Differences between the Ccl2 and Cx3cr1 double deficient mouse on Crb1(rd8) (rd8) background (DKO (rd8) ) and the Crb1(rd8) mouse in photoreceptor and RPE pathology, ...
Yamamoto Nobuko - - 2013
Large cell neuroendocrine carcinoma (LCNEC) of the salivary gland is extremely rare. We report on a case of LCNEC in the submandibular gland. A 58-year-old male had a four-month history of an enlarging mass in his left submandibular region. He underwent lymph node resection and metastasis of LCNEC was suspected. ...
Badal Sheeraz S Department of Oral and Maxillofacial Surgery, MIDSR Dental College and Hospital, Latur, Maharashtra, - - 2013
Malignant myoepithelioma is an extremely rare tumor of the salivary glands. Myoepitheliomas make up less than 1% of all salivary gland tumors. We report of a case of malignant myoepithelioma of the upper jaw in a 55-year old man. The tumor primarily arose from the maxillary sinus and secondarily involved ...
Patel Vishal V Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. - - 2013
Polycystic kidney disease (PKD), the most common genetic cause of chronic kidney failure, is characterized by the presence of numerous, progressively enlarging fluid-filled cysts in the renal parenchyma. The cysts arise from renal tubules and are lined by abnormally functioning and hyperproliferative epithelial cells. Despite recent progress, no Food and ...
Virani Sophia - - 2013
PROBLEM: Endometriosis affects 5-10% of women and is characterized by the growth of endometrial tissue outside of the uterus. Establishing new blood supply is a fundamental requirement for endometriosis lesion growth. Endothelial progenitor cells (EPCs), recruited by stromal cell-derived factor-1 (SDF-1), contribute to neoangiogenesis in endometriotic lesions. We hypothesized that ...
Happé Hester - - 2013
Autosomal-dominant polycystic kidney disease is characterized by progressive cyst formation and fibrosis in the kidneys. Here we describe an orthologous Pkd1nl,nl mouse model, with reduced expression of the normal Pkd1 transcript, on a fixed genetic background of equal parts C57Bl/6 and 129Ola/Hsd mice (B6Ola-Pkd1nl,nl). In these mice, the first cysts ...
Rudzitis-Auth J - - 2013
STUDY QUESTION: Does the phytochemical compound resveratrol inhibit vascularization of endometriotic lesions? SUMMARY ANSWER: Resveratrol suppresses the development of new microvessels in endometriotic lesions by inhibiting endothelial cell proliferation. WHAT IS KNOWN ALREADY: Establishment and progression of endometriosis is crucially dependent on angiogenesis. Resveratrol is a pleiotropic agent, which dose-dependently ...
Harrison John D - - 2013
The mylohyoid hiatus and hernia were discovered in the nineteenth century and were considered to explain the origin of the plunging ranula from the sublingual gland. This formed the rationale for sublingual sialadenectomy for the treatment of plunging ranula. However, a more recent, extensive histological investigation reported that hernias contained ...
Portela Ana - - 2013
Purpose: Evaluation of the effectiveness of highly focalised thermotherapy (HFT) in a melanoma mouse model, using a ferrimagnetic cement (FC) and repeated low hyperthermia treatments. Materials and methods: A melanoma mouse model was induced with B16F10 cells in C57BL6 mice. The FC, injected into the tumour, was used as the ...
Kamra Hemlata T - - 2013
Plexiform neurofibroma is more commonly seen in the orbit, neck, back, and inguinal region. It is extremely rare in the submandibular gland. These lesions rarely transform into malignancy but are locally infiltrative and can lead to haemorrhage. Therefore, plexiform neurofibroma should always be considered during differential diagnosis while excising a ...
Pattnaik Niharika - - 2013
Sebaceous lymphadenoma is a rare primary tumour of the salivary gland, benign in nature arising from differentiated Sebaceous glands and cells in the salivary gland. Most of the tumours are seen in the parotid gland and very rarely in the submandibular gland. Herein a case of sebaceous lymphadenoma is reported ...
Devan Shobana Mukunda - - 2013
The objective of this study is to assess tissue expression of CA-125 and HE4 protein in primary benign and malignant epithelial tumours of the ovary and correlate with serum CA-125 levels. A total of 100 formalin-fixed, paraffin embedded sections of ovarian tumours which included serous adenoma (11), mucinous adenoma (42), ...
Riahi Ryan R - - 2013
A variety of tumors mimicking keratoacanthoma have been described. Herein we categorize metastases of visceral malignancies that can present with the appearance of a keratoacanthoma.
Chu Xi K - - 2012
Tuo et al. (2012) demonstrated tumor necrosis factor-inducible gene 6 recombinant protein (TSG-6) arrest of focal retinal lesions on a Ccl2 and Cx3cr1 double deficient mouse (DKO) on rd8 background (hereon referred to as DKO rd8). DKO rd8, a model of focal retinal degeneration with earlier onset and higher penetrance ...
Goncharova Elena A - - 2012
Pulmonary lymphangioleiomyomatosis (LAM) is a rare genetic disease characterized by neoplastic growth of atypical smooth muscle-like LAM cells, destruction of lung parenchyma, obstruction of lymphatics, and formation of lung cysts, leading to spontaneous pneumothoraces (lung rupture and collapse) and progressive loss of pulmonary function. The disease is caused by mutational ...
Ozkan Ozlenen - - 2012
Although rare, malignant melanoma occurs in children. The risk of degeneration of a congenital melanocytic nevus into a melanoma is approximately 0.7%. We report a case of malignant melanoma that developed on a congenital melanocytic nevus in a 19-month-old boy. The child was treated by surgical resection, superficial parotidectomy, and ...
Stayner Cherie - - 2012
SUMMARY AT A GLANCE: Stayner et al. investigated the effect of rapamycin on polycystic kidney disease in utero. Their data showed the potential beneficial effects of rapamycin administered during pregnancy in a rodent model of PKD, while cyst number remains unchanged; the size of the cysts is reduced by rapamycin ...
Sun Hongjia - - 2012
To better control tuberculosis (TB) epidemics in developing countries a real need exists to study the liquefaction and cavity formation that occur in pulmonary TB lesions. This report is the first to evaluate the effects of immunomodulators on these two processes in a rabbit skin model. The effects of recombinant ...
Zhou Hong - - 2012
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disease characterized by massive enlargement of fluid-filled cysts in the kidney. However, there is no effective therapy yet for this disease. To examine whether ginkgolide B, a natural compound, inhibits cyst development, a Madin-Darby canine kidney (MDCK) cyst model, an ...
Noguchi Miho - - 2012
The biological consequences of clusters containing a single strand break and base lesion(s) remain largely unknown. In the present study we determined the mutagenicities of two- and three-lesion clustered damage sites containing a 1-nucleotide gap (GAP) and 8-oxo-7,8-dihydroguanine(s) (8-oxoG(s)) in Escherichia coli. The mutation frequencies (MFs) of bi-stranded two-lesion clusters ...
Figueira Ana Catarina AC Escola Universitária Vasco da Gama (EUVG), Quinta de S. Jorge, Estrada da Conraria, Castelo Viegas, 3040-714 Coimbra, Portugal ; Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (ICBAS-UP), Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, - - 2012
The search for molecular markers in the feline mammary gland, namely, the adhesion molecules belonging to the cadherin family, is useful in the understanding of the development of mammary carcinomas in felines and humans. To study P-cadherin expression in the feline mammary gland, 61 samples of normal (n = 4), ...
Kokgil Tuba D - - 2011
Three major and three minor types of acral melanocytic lesions have been described: parallel furrow, lattice-like, fibrillar, reticular, homogeneous and globular. To examine the dermoscopic patterns of acral melanocytic lesions and to investigate the association of these patterns with clinical features. This study included 419 acral melanocytic lesions of 295 ...
Kaz Andrew M - - 2011
Barrett's esophagus (BE) is a metaplastic process whereby the normal stratified, squamous esophageal epithelium is replaced by specialized intestinal epithelium. Barrett's is the only accepted precursor lesion for esophageal adenocarcinoma (EAC), a solid tumor that is rapidly increasing in incidence in western countries. BE evolves into EAC through intermediate steps ...
Fan L - - 2012
To evaluate different features between benign and malignant pulmonary focal ground-glass opacity (fGGO) on multidetector CT (MDCT). 82 pathologically or clinically confirmed fGGOs were retrospectively analysed with regard to demographic data, lesion size and location, attenuation value and MDCT features including shape, margin, interface, internal characteristics and adjacent structure. Differences ...
van der Lijn Fedde F Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands. - - 2012
It has been hypothesized that white matter lesions at different locations may have different etiology and clinical consequences. Several approaches for the quantification of local white matter lesion load have been proposed in the literature, most of which rely on a distinction between lesions in a periventricular region close to ...
Liang Xiaojun - - 2011
ABSTRACT: The significance of anatomic divisions of the orbital and sinus regions in providing guidance for nasal endoscopic resection of benign space-occupying lesions was discussed. This retrospective study included 177 cases with benign space-occupying lesions of the orbital and sinus resected between 2001 and 2009. Locations of lesions were assigned ...
Drut Ricardo - - 2011
Little is known of early histologic changes in the mucosa of the colon aside from the polyps in Juvenile Polyposis. Provided with a surgical specimen of a total colectomy of a 6-year-old boy with this condition, this report describes those changes. The mucosa depicted a peculiar serrated profile of the ...
Fajardo Daniel A - - 2011
The presence of a Gleason pattern 5 prostatic adenocarcinoma is associated with a worse outcome. This study assesses the accuracy of grading a tumor as having Gleason pattern 5 and the potential factors contributing to its undergrading. From the consultation service of one of the authors, we identified 59 consecutive ...
Fortina Anna Belloni - - 2011
BACKGROUND: : The first step in the analysis of a dermatoscopically imaged melanocytic lesion is segmentation - informally, isolating those points in the image belonging to the lesion from those belonging to the surrounding non-lesional skin. Although typically studied in the context of automated analysis, segmentation is a necessary step even ...
Reginster Marie-Annick - - 2012
At present, immunohistochemistry is taken for granted in the establishment of malignant melanoma (MM) diagnosis. In recent years, molecular diagnosis in dermatopathology has benefited from a vast array of advances in the fields of genomics and proteomics. Sensitive techniques are available for detecting specific DNA and RNA sequences by molecular ...
Shetty Shishir Ram - - 2011
Gerodontology 2011; doi: 10.1111/j.1741-2358.2010.00415.x Palatal schwannoma in an elderly woman Schwannoma also known as neurilemmoma is a benign tumour derived from schwann cells and is relatively rare in occurrence. Only 1% of the schwannomas in the head and neck region occur at intra-oral sites. Schwannomas usually occur during the third ...
Rivera Rebecca - - 2011
A seven-year old California sea lion (Zalophus californianus) presented with focally extensive, bilaterally symmetric, proliferative axillary skin lesions and preputial lesions. A second California sea lion in the same population presented with similar proliferative lesions on the underside of the tail. Histopathology revealed epidermal hyperplasia with severe hyperkeratosis, with proliferating ...
- - 2011
Background: Pineal cysts are benign glial uniloculated or multiloculated fluid-filled sacs located in the pineal gland region. Small pineal cysts are often found incidentally in healthy adults in 1.5-10.8%. Large cysts may cause neurological problems due to pressure exertion on adjacent structures. Methods: We have used prospective, observational study of ...
Torres-Tabanera M - - 2011
OBJECTIVES: The positive predictive values (PPV) of the subcategories of BI-RADS(®) 4 lesions (A/B/C) vary widely, and their correlation with specific descriptors has yet to be defined. We aimed to analyze the PPV of the subcategories and of the mammographic and ultrasonographic descriptors assigned to each. MATERIAL AND METHODS: We ...
Crenshaw Charisse M - - 2011
The base lesion 8-oxoguanine is formed readily by oxidation of DNA, potentially leading to G → T transversion mutations. Despite the apparent similarity of 8-oxoguanine-cytosine base pairs to normal guanine-cytosine base pairs, cellular base excision repair systems effectively recognize the lesion base. Here we apply several techniques to examine a ...
Jaeger Teresa - - 2011
Cherry angioma is a common, acquired, vascular proliferation, probably of a polygenic mode of inheritance. Segmental manifestation of multiple cherry angiomas associated with the development of non-segmental lesions has not yet been reported. We describe a 62-year-old Caucasian woman with early formation of segmental cherry angiomas after pregnancy, which are ...
Lykkjen S S The Norwegian School of Veterinary Science, Department of Basic Sciences and Aquatic Medicine, Norway. - - 2012
Developmental orthopaedic diseases (DOD) such as osteochondrosis (OC)/osteochondrosis dissecans (OCD), palmar/plantar osteochondral fragments (POF), ununited palmar/plantar eminences (UPE) and dorsoproximal first phalanx fragments are well recognised in the horse. Aetiopathogeneses are controversial and molecular genetic screening of DNA has recently been employed for their elucidation. Precise phenotypic definition and knowledge ...
Leonard D F - - 2011
Serrated polyps are an inhomogeneous group of lesions that harbour precursors of colorectal cancer. Current research has been directed at further defining the histopathological characteristics of these lesions, but definitive treatment recommendations are unclear. The aim was to review the current literature regarding classification, molecular genetics and natural history of ...
1 2 3 4 5 6 7 8 9 10 >