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Shitara Danielle D Melanoma Unit, Dermatology Department, Hospital Clinic of Barcelona, IDIBAPS, Barcelona, - - 2014
In order to determine dermoscopic parameters, a case-control test set of naevus-associated melanomas vs de novo melanomas paired by Breslow thickness and histopathological subtype was analysed by 2 blinded experienced dermoscopists, according to presence of naevus, pattern analysis and ABCD dermoscopy score. The ability to identify naevus-associated melanomas by pattern ...
Beghi Ettore E Department of Neuroscience, IRCCS - Institute for Pharmacological Research 'Mario Negri', Milan, - - 2014
Background: There is only one small single-center study on the reliability of the diagnosis of focal dystonia. The aim of this study was to assess the inter-rater reliability of dystonia diagnosis among neurologists with different professional experience. Methods: Twenty-nine adults (18 with dystonia, 9 with other movement disorders, and 2 ...
Wilhelmus Suzanne S Departments of Pathology and - - 2014
To treat lupus nephritis effectively, proper identification of the histologic class is essential. Although the classification system for lupus nephritis is nearly 40 years old, remarkably few studies have investigated interobserver agreement. Interobserver agreement among nephropathologists was studied, particularly with respect to the recognition of class III/IV lupus nephritis lesions, ...
Jenkins Catharine C Birmingham City - - 2014
The government proposes to pay GPs £55 for every diagnosis of dementia they make. The aim is to motivate doctors to assess and diagnose dementia so that the number of people identified as living with dementia matches the expected prevalence of the condition.
Dabouz F F Service de Dermatologie, Hôpital Robert Debré, CHU de Reims, - - 2014
Head and neck melanomas (HNM) account for an increasing proportion of melanomas and have a poor prognosis. Few population-based studies have focused on specific characteristics of these tumors. To compare clinical and histological characteristic of HNM with those of melanomas at other sites (MOS) and identify pertinent clinico-pathological subgroups of ...
Ross Keir A KA Department of Orthopaedic Surgery, Foot and Ankle Service, Hospital for Special Surgery, 523 East 72nd Street, East River Professional Building, 5th Floor, Room 507, New York, NY 10021. E-mail address for K. Ross: RossK@hss.edu. E-mail address for J.G. Kennedy: - - 2014
Osteochondral lesions of the distal tibial plafond are uncommon compared with talar lesions. The objective of this study was to assess functional and magnetic resonance imaging (MRI) outcomes following microfracture for tibial osteochondral lesions. Thirty-one tibial osteochondral lesions in thirty-one ankles underwent arthroscopic microfracture. The Foot and Ankle Outcome Score ...
Kruse C C Oral Radiology, Department of Dentistry, Aarhus University, Aarhus, - - 2014
To evaluate using a systematic review approach the diagnostic efficacy of CBCT for periapical lesions, focusing on the evidence level of the included studies using a six-tiered hierarchical model. The MEDLINE bibliographic database was searched from 2000 to July 2013 for studies evaluating the potential of CBCT imaging in the ...
Helles Adam A Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, - - 2014
To examine the diagnostic stability of a childhood diagnosis of Asperger Syndrome (AS) into adulthood in a prospective longitudinal study, and identify the predictors of stability. One hundred males with AS diagnosed in childhood (T0) according to Gillberg's AS criteria, were followed up prospectively into adulthood over an average of ...
Mori Ichiro I Department of Pathology, Mita Hospital, International University of Health and Welfare, Tokyo, - - 2014
In Japan, we have about 2000 board-certified pathologists. Most of them are working in the cities, thus few are available in the countries. Telepathology in Japan developed under these situations mainly to cover intra-operative frozen section diagnosis of rural hospitals. First, I would like to introduce telepathology network in Wakayama ...
Aiwansoba Imarhiagbe Frank IF Neurology Unit, Department of Medicine, University of Benin Teaching Hospital, Benin City, Nigerian; West African Health Organisation's 2012 PEPL Research Fellow, CHNU, Dakar, Senegal, - - 2014
The Benin stroke score (BSS) is a validated tool in the diagnosis of intracerebral hemorrhage (ICH) but not in the diagnosis of brain infarct. The aim of this report is to specifically validate the BSS in the clinical diagnosis of acute brain infarct. A total of 60 participants with a ...
Maia Ana Luiza AL Unidade de Tireoide, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, - - 2014
Introduction Medullary thyroid carcinoma (MTC) originates in the thyroid parafollicular cells and represents 3-4% of the malignant neoplasms that affect this gland. Approximately 25% of these cases are hereditary due to activating mutations in the REarranged during Transfection (RET) proto-oncogene. The course of MTC is indolent, and survival rates depend ...
Ganguly Akash A Warrington & Halton Hospitals NHS Foundation - - 2014
Objectives To perform a systematic review of ultrasound guided FNA services for head and neck lesions with assessment of inadequacy rates and related variables such as the presence of immediate cytological assessment. Methods A computer based systematic search of articles in English Language was performed using MEDLINE (1950 to date) ...
Bakry Ola Ahmed OA Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University , Shibeen El Koom , Egypt - - 2014
Abstract Nuclear factor kappa B (NFκB) is a key regulatory element in a variety of immune and inflammatory pathways, cellular proliferation, differentiation and apoptosis. Cyclo-oxygenase 2 (COX2) is one of the downstream targets of NFκB. The current work aimed to explore the possible role of NFκB and COX2 in psoriasis ...
Strazzula Lauren L UMass Memorial Healthcare, University of Massachusetts Medical School, Worcester, - - 2014
Pediatric fasciitides are rare benign lesions that may clinically mimic a malignant sarcoma. Nodular fasciitis, the most common of these fasciitides, rarely occurs in children younger than 5 years of age. Often there is a history of preceding trauma. Herein, we report the case of a 5-month-old boy diagnosed with ...
van der Marel J J Department of Research and Development, DDL Diagnostic Laboratory, Visseringlaan 25, 2288ER Rijswijk, The Netherlands. Electronic address: - - 2014
It has been suggested that colposcopy can miss a significant percentage of high-grade cervical intraepithelial neoplasia (CIN2+). Improved disease ascertainment was evaluated by taking multiple lesion-directed biopsies. In a cross-sectional multicentre study in the Netherlands and Spain, 610 women referred to colposcopy following abnormal cervical cytology results were included. Multiple ...
Eisenhofer Graeme G Institute of Clinical Chemistry & Laboratory Medicine, Technische Universität Dresden, Dresden, Germany; Department of Medicine III, Technische Universität Dresden, Dresden, - - 2014
We have noted the letter by Chortis et al.(1) published in response to our report about supine versus seated blood sampling for diagnosis of phaeochromocytoma.(2) There are several issues that the authors have missed and which they might wish to consider further in relation to their cost analysis and the methods ...
Kholová Ivana I Department of Pathology, Fimlab Laboratories, Tampere University Hospital, Tampere, - - 2014
Objective: The Bethesda System for Reporting Thyroid Cytopathology (BSRTC) was introduced in thyroid cytology in 2007 and is now generally accepted. BSRTC categories include a morphologic description and risk of malignancy as well as follow-up suggestions in each group. However, the category entitled 'atypia of undetermined significance or follicular lesion ...
Morrison Megan M St. Joseph Mercy Hospital, Department of Dermatology, Ypsilanti, MI, USA. Email: - - 2014
At first, there was no obvious cause for the lesion on this patient's foot, which had slowly grown over 2 years. However, a more detailed history proved revealing.
Rahangdale Lisa L Departments of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, N.C., - - 2014
Objective: It was the aim of this study to assess the utility of the manual liquid-based cytology (LBC) product VitroPrep™ Cytology Processing Kit (ChemQ Bioscience LLC, Research Triangle Park, N.C., USA). Study Design: This is a descriptive pilot study. Women underwent cervical sampling processed by the ThinPrep™ automated LBC system ...
Shah Rajal B RB Division of Urologic Pathology, Miraca Life Sciences Research Institute, Miraca Life Sciences, Irving 75039, TX. Electronic address: - - 2014
Accurate recognition of Gleason pattern 5 (GP5) prostate adenocarcinoma (PCa) on core biopsy (NBX) is critical because it is associated with disease progression and the worst clinical outcome. We evaluated 1557 consecutive and prospectively collected NBXs to determine the frequency of diagnosis, morphologic subpatterns, and their relation to the amount ...
Azad Aftab - - 2014
Clinical questionCan ultrasonography be used in lieu of chest radiography to diagnose pneumothorax?Articles chosen1. Ding W, Shen Y, Yang J, et al. Diagnosis of pneumothorax by radiography and ultrasonography: a meta-analysis. Chest 2011;140:859-66. [Epub 2011 May 5]2. Alrajhi K, Woo MY, Vaillancourt C. Test characteristics of ultrasonography for the detection ...
Omoregie Fo F University of Benin Teaching Hospital, Department of Oral Pathology/Oral Medicine, PMB 1111 , Benin, Edo State, 300001 - - 2014
This study aims to determine the incidence, age, gender, orofacial sites and histological pattern of paediatric orofacial tumours in a Nigerian population. The yearly findings will be analysed to identify the interval for increase in the incidence of paediatric orofacial tumours. A 21-year (1990 to 2010) retrospective analysis of paediatric ...
Hasanzadeh Malihe M Women Health Research center, Dept. of Gynecology Oncology, Mashhad University of Medical Sciences, Mashhad, - - 2014
Invasive squamous cell carcinoma of the vulva is primarily a disease of postmenopausal women and thus is rarely associated with pregnancy. We have reported on a young woman under 40 years old with vulvar carcinoma, which occurred during the pregnancy but optimal treatment was delayed to the postpartum period. This ...
Lobato-Berezo Alejandro A 0000-0001-8725-3999 Department of Dermatology, Hospital Universitario Severo Ochoa, Avenida Orellana s/n, Leganés, 28911 Madrid, - - 2014
Many complications have been reported over tattoos, some of which are tumours, such as dermatofibromas. It is important to establish a differential diagnosis because they can resemble other malignant lesions as dermatofibrosarcoma protuberans. We report the development of a dermatofibroma in a 21-year-old man with a tattoo painted two years ...
Santos Simeão Rodrigo SR Postgraduate Community Health Program, School of Medicine of Ribeirão Preto, University of São Paulo, - - 2014
To determine the characteristics of undiagnosed chronic obstructive pulmonary disease (COPD) in a senior community center. We performed a cross-sectional, observational study with the following procedures: questionnaire to record demographic and health status data, anthropometry, questionnaire about COPD risk factors and symptoms, spirometry, and socioeconomic evaluation. Simple logistic regression and ...
Biolcati G - - 2013
Hailey-Hailey disease (HHD) is a rare, chronic and recurrent blistering disorder, which is characterized clinically by erosions occurring primarily in intertriginous regions, and histologically by suprabasal acantholysis. Oxidative stress plays a specific role in the pathogenesis of HHD, by regulating the expression of factors playing an important role in keratinocyte ...
Muizzuddin Neelam - - 2013
A major component to the etiology of acne is the growth and invasion by Propionibacterium acnes. Hydrogen peroxide is an excellent antimicrobial agent but is unstable in most formulations. We have developed a hydrogen peroxide generation system using the enzyme glucose oxidase and glucose. This system is stable in a ...
Bi Wenjing - - 2012
We report the uncommon case of a pericardial cyst with unremitting compression of the left ventricle during the whole cardiac cycle, but normal ejection fraction. On CT scan, the cyst was found at an atypical location, lateral to the pulmonary artery, the ascending aorta, and the right ventricular outflow tract ...
Vertemati Maurizio - - 2012
We generated a computerized morphometric model to evaluate and quantify the morphological features in large regenerative nodules (LRN), high-grade dysplastic nodules (HGDN) and hepatocellular carcinoma (HCC). Sixteen LRN, 10 HGDN and 16 HCC in HCV-cirrhotic livers were stained with H&E, smooth muscle actin, CD34, CD31 and reticulin to evaluate volume ...
Lalancette Cindy - - 2012
Cryptosporidium and Giardia (oo)cyst concentrations are frequently used for assessing drinking water safety. The widely used USEPA Method 1623 provides total counts of (oo)cysts, but may not be accurate for human health risk characterization, since it does not provide infectivity information. The total counts and infectious fraction of Cryptosporidium oocysts ...
Ben-Dor Itsik - - 2012
BACKGROUND: A fractional flow reserve (FFR) of <0.8 is currently used to guide revascularization in lesions with intermediate coronary stenosis. Whether there is an intravascular ultrasound (IVUS) measurement or a cutoff value that can reliably determine which of these intermediate lesions requires intervention is unclear. AIMS: We assessed IVUS measurement ...
Maeda Kengo - - 2011
Alexia with agraphia results from lesions of the left angular gyrus or the left posteroinferior temporal lobe. In Japanese or Korean persons, lesions of the latter cause alexia with agraphia for ideograms. We describe a case of alexia with agraphia for kanji (Japanese ideograms) caused by temporal lobe epilepsy. After ...
Simpkins Alexis - - 2011
Mycoplasma pneumoniae is a well-known cause of atypical pneumonia. CNS involvement is a relatively frequent extrapulmonary manifestation, most commonly manifesting as encephalitis in the pediatric population. We present two unusual cases of M. pneumoniae encephalitis that presented with symptoms and imaging findings suggesting mass occupying lesions, and worsening altered mental ...
Chiu Han-Mo - - 2011
Growing body of evidences have shown that narrow band imaging (NBI) can be the adjunct tool of colonoscopy for real time or optical histological assessment with high accuracy and largely replaces the role of chromoendoscopy. In spite of the advantages, there are still several issues that remain to be elucidated: ...
Bilgili Serap Gunes - - 2011
Pellagra is characterized by dermatitis, diarrhea, dementia and eventually death occurring as a result of niacin or its precursor tryptophan deficiency. Although pellagra is a well-known complication of isoniazid (INH) therapy, the clinical diagnosis may be missed or delayed that may cause life-threatening consequences. Due to the diversity of pellagra-related ...
Studer U - - 2011
Central nervous system involvement is a rare and serious complication of Behçet's disease (BD). Herein, we describe a patient with an atypical central lesion, who experienced progressive hypesthesia of the right arm and sensory loss of the trigeminal nerve together with intense headache. A repeated biopsy was necessary to conclusively ...
Patel Mrinali - - 2011
Uveal melanoma represents the most common primary intraocular malignancy in adults. Although uveal and cutaneous melanoma both arise from melanocytes, uveal melanoma is clinically and biologically distinct from its more common cutaneous counterpart. Metastasis occurs frequently in this disease, and, once distant spread occurs, outcomes are poor. No effective systemic ...
Incorvaia Cristoforo - - 2011
Diagnosis and treatment of hypersensitivity to Hymenoptera venom took a landmark step forward in the late 1970s with the introduction of venom as an adequate material instead of whole body extracts. Since then, venom immunotherapy (VIT) has provided allergic subjects with a complete protection from fatal anaphylaxis and prevented about ...
Donelson Ronald - - 2011
Despite its classic clinical presentation, and even when confirmed by compatible imaging findings of a herniated disc, the radiculopathy diagnosis provides only limited assistance for making decisions about treatment. The 2003 Medicare data revealed an eightfold variation in the rates of lumbar laminectomy and discectomy across geographic regions. In an ...
Held Laura - - 2011
Our understanding of oncogenetics and of the molecular mechanisms involved in melanoma development and signaling has dramatically changed in recent years. Today, melanomas are also classified based on molecular alterations. Emerging molecular therapies are targeted against specific mutations in melanoma. An example of targeted therapies is the successful treatment of ...
Kim Tae W - - 2011
Patients with malignant hyperthermia experience an exaggerated metabolic response when exposed to volatile anesthetic gases and succinylcholine. The minimum concentration of anesthetic gas needed to trigger a malignant hyperthermia crisis in humans is unknown and may remain so because of the inherent risks associated with studying the complex nature of ...
Anon Jack B - - 2011
Hereditary angioedema (HAE) is a relatively rare genetic disorder that is usually characterized by either low levels of C1 esterase inhibitor (C1-INH) or the presence of dysfunctional C1-INH. It can present with relatively mild and self-limiting symptoms, but it is also potentially fatal; the most common cause of death is ...
Sakurai Yasuhisa - - 2011
The author reviews the lesion localization of non-aphasic alexia and agraphia and proposes a new classification of alexia and agraphia on this basis. The newly proposed alexia and agraphia are pure alexia for kana (Japanese phonograms), or more generally pure alexia for letters, caused by a lesion in the posterior ...
Yamasaki Kouji - - 2011
A 51-year-old immunocompetent Japanese woman presented with a rare case of granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris. She was brought to our hospital with epilepsy. Magnetic resonance imaging of the brain revealed a homogeneously enhanced solitary mass in the left frontal lobe. Histological diagnosis was made by a ...
Okazaki Kenichi - - 2010
We report the autopsy findings of a 63-year-old man with neurofibromatosis type 1 (NF1), in whom widespread ischemic brain lesions caused by vasculopathy associated with the disorder were observed. The patient, who had café au lait macules, axillary freckling, and neurofibromas, was inarticulate of speech, had difficulty in maintaining a ...
Baker K - - 2010
The differential diagnosis of large cystic brain lesions is wide. In the UK the most likely is tumour but infection should be considered. We present the case of a 47-year-old Indian man with such lesions and an unexpected pathological diagnosis. Mr S attended MAU in March 2008 with confusion, agitation ...
Petrovic Nebojsa S - - 2010
(i) To examine blood perfusion and metabolic activity of various brain tumours using radionuclide cerebral angiography (RCA) and single-photon emission tomography (SPET) after a single dose of Tc-methoxyisobutylisonitrile (MIBI). (ii) To examine if the inclusion of RCA can improve insight into the relative contribution of tumour perfusion to the uptake ...
Abdel-Aziz K - - 2010
A 51-year-old presented with subacute headache, right facial weakness and numbness. MRIB showed widespread enhancing hemispheric lesions with a focal lesion of the right CN VII nucleus. CSF protein 0.84 g/l; CSF lymphs 10×10(6)/l. A diagnosis of ADEM was made and symptoms resolved soon after steroids. Five months later, he ...
Elbers Jorina - - 2010
Primary angiitis of the central nervous system in childhood (cPACNS) is an immune-mediated inflammatory process directed toward blood vessels in the central nervous system. It has been associated with variable clinical and radiological presentations, and devastating consequences without treatment. Brain biopsy is required for definitive diagnosis. The objective of this ...
Pantazis G - - 2010
Herein, we report the case of a 72-year-old male with an exceedingly rare manifestation of a low-grade lymphoma in the brain associated with light chain deposition disease (LCDD). The patient presented with epileptic seizures. Magnetic resonance imaging (MRI) of the brain revealed multiple hyperintense lesions in the right parietal lobe ...
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