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Wee Aileen A Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, National University Hospital, National University Health System, - - 2014
The differential diagnoses of fine needle aspiration (FNA) biopsy of a well-differentiated hepatocellular nodule (WDHN) in a woman with hepatitis B cirrhosis are discussed. Radiological diagnosis was a large regenerative nodule containing fat.Establish representative sampling.In cirrhosis, differential diagnosis include large regenerative nodule, dysplastic nodule (low- or high-grade), and early to ...
Bertoni Franco F 1University of Bologna 2Villa Erbosa Hospital Bologna, - - 2014
Bone-forming lesions and cartilage-forming lesions are the most common primary tumors of the bone. They are classified according to their biological potential as benign (chondroblastoma, chondromyxoid fibroma, enchondroma, osteochondroma, periosteal chondroma) and malignant (chondrosarcoma, clear cell chondorsarcoma, mesenchymal chondrosarcoma, dedifferentiated chondrosarcoma) and as to their anatomic location (central/intramedullary, or peripheral ...
Wee Aileen A Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, National University Hospital, National University Health System, - - 2014
Focal liver lesions with glandular features encompass inflammatory, hyperplastic, hamartomatous to neoplastic lesions. They can be solid/cystic, solitary/multiple, occurring in a normal/diseased liver. Hepatobiliary entities should be segregated before considering nonhepatobiliary conditions.In small tissue samples such as fine needle aspiration (FNA) or core biopsy, the diagnostic issues are to distinguish/recognize ...
Gao Zu-Hua ZH McGill University, - - 2014
Primary mesenchymal tumors represent a rare subset of hepatic lesions with overlapping spindle cell morphology. These lesions pose unique diagnostic challenges for pathologists as they are infrequently seen in general practice and can be easily mistaken for their benign counterparts or mimickers. In the current era of personalized medicine, precise ...
Lee Dong-Youn DY Samsung Medical Center, Sungkyunkwan University, Seoul, - - 2014
A 43-year-old woman presented with skin rash on the body which had developed 5 years ago. Several years ago she was diagnosed with parapsoriasis. She received phototherapy with some improvement in another hospital. She complained of itching. Skin examination showed multiple erythematous patches and plaques on the body. Skin biopsy ...
Zheng Yan Y Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. - - 2014
Eccrine spiradenoma (ES) is a rare, benign adnexal neoplasm that may easily be mistaken for glomus lesions or angioleiomyoma due to its painfulness and florid vascularization. A 44-year-old male with a blue-colored, nodular tumor on the left knee, present for 10 years, was submitted for diagnosis. Dermatological examination was undertaken, ...
Zhang Xianghong X Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. - - 2014
Photodynamic therapy (PDT) has clinical approval for use as a minimally invasive therapeutic procedure that is able to exert selective cytotoxic activity toward pathological cells, particularly malignant cells. Following a number of recent technological improvements, PDT has been widely applied to the diagnosis and treatment of malignancies, including lung, esophageal, ...
Trindade Felicidade F *Department of Dermatology, Hospital de Cascais Dr. José de Almeida, Lisbon, Portugal; †Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain; ‡Dermatohistopathologische Gemeinschaftslabor, Friedrichshafen, Germany; §Department of Dermatology, Fundación Jiménez Díaz, Madrid, Spain; ¶Department of Dermatology, Hospital Universitário de Coimbra, Coimbra, Portugal; and ‖Department of Pathology, Hospital Infantil Universitario Niño Jesús, Madrid, - - 2014
Angiokeratomas are vascular anomalies in which the clinical, histological, and immunohistochemical characteristics are insufficient to determine whether the lesion is a vascular neoplasm or vascular malformation, and their exact origin is also uncertain. To further clarify the nosology of angiokeratomas, we studied 14 cases. To analyze immunohistochemical characteristics of angiokeratomas ...
Rajabi Mohammad Taher MT Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences , Tehran , - - 2014
Abstract Background: Orbital and periorbital presentation is rare for malignant peripheral nerve sheath tumors. These tumors are poorly defined spindle cell neoplasms of peripheral nerves and have not been reported to develop in the lacrimal gland to date. Aim: To report a rare presentation of malignant peripheral nerve sheath tumor ...
Hayashi Toshitetsu T Department of Pathology, University Health Network, 200 Elizabeth Street, 11th floor, Toronto, ON, M5G2C4, - - 2014
The adrenal gland is a site of various neoplasms; however, it is rarely involved by sarcomas. We present herein an unusual adrenal neoplasm consisting of epithelioid angiosarcoma and adrenal cortical adenoma. In this report, the authors highlight the diagnostic challenges associated with an epithelioid angiosarcoma occurring in an adrenal cortical ...
Leclercq D D Neuroradiology Department, Pitié-Salpêtrière Hospital, 47-83, boulevard de l'Hôpital, 75013 Paris, France. Electronic address: - - 2014
Pseudotumoral lesions are uncommon but important to identity lesions. They can occur during inflammatory diseases (systemic diseases, vasculitis, demyelinating diseases), infectious, and vascular diseases. Also, in a patient with a treated tumor, pseudo-progression and radionecrosis must be differentiated from the tumoral development. Diagnosis can be difficult on an MRI scan, ...
Sinha R R Department of Dermatology, Chelsea & Westminster Hospital NHS Foundation Trust, 369 Fulham Road, London, SW10 - - 2014
Vemurafenib was the first BRAF inhibitor to be licensed for the treatment of metastatic melanoma. It is associated with a spectrum of cutaneous toxicities including benign and malignant squamous proliferations.(1,2) Treatment of these lesions can be challenging as the lesions may be eruptive and frequent. Effective skin preserving therapeutic measures ...
Maa Hung-Chune HC *Department of Pathology †Medical Research Center ‡Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine §Department and Institute of Life-Science ∥Department of Chemistry ¶Graduate Institute of Basic Medicine, Fu-Jen Catholic University, New Taipei, - - 2014
The sensitivity in cytology diagnosis of malignant metastatic pleural effusion (MMPE) is insufficient nowadays due to the similarity of the reactive mesothelial cells and malignant cells. Vascular endothelial growth factor (VEGF) is one of the key factors in tumor lymphangiogenesis and metastasis. Therefore, the aim of this study was to ...
Lau Darryl D Department of Neurological Surgery, University of California, San Francisco, - - 2014
Malignant peripheral nerve sheath tumors (MPNSTs) are rare, affecting only a small portion of the general population. In many cases, MPNSTs occur in association with neurofibromatosis Type 1 and at times arise secondary to previous radiation therapy (RT). These tumors can be found essentially anywhere a peripheral nerve is present, ...
Choi Jin Woo JW Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, - - 2014
Background and study aims: A diagnostic molecular marker for pre-neoplastic lesions, particularly before polyposis, is still lacking. Lgr5 has been broadly accepted as a marker for intestinal cancer stem cells. The aim of this study was to investigate the monitoring of Lgr5( + ) cells as a useful tool for the early ...
Taylor Steve S Departments of *Pathology and Laboratory Medicine †Hematology and Oncology ‡Surgery §Radiology, Phoenix Children's Hospital, Phoenix, - - 2014
Diffuse malignant peritoneal mesotheliomas in children are uncommon, aggressive tumors with a grave prognosis. We herein report the clinical, radiologic, and pathologic findings of a 16-year-old male. The adolescent presented with a history of abdominal pain, nausea and daily, nonbilious, nonbloody emesis for 3 weeks. Radiographic imaging suggested small bowel ...
Kuwamoto Satoshi S Department of Pathology, Tottori University Hospital, Yonago, - - 2014
Background: Renal carcinomas associated with Xp11.2 translocations/TFE3 gene fusions are rare subtypes of renal neoplasm that predominantly occur in younger individuals. There are very few reports describing the cytologic features of these tumors. Case: A 27-year-old man presented with hematuria and was found to have a mass in the lower ...
Héran F F A. de Rothschild Foundation, Imaging Department, 25, rue Manin, 75019 Paris, France. Electronic address: - - 2014
The term orbital tumor covers a wide range of benign and malignant diseases affecting specific component of the orbit or developing in contact with them. They are found incidentally or may be investigated as part of the assessment of a systemic disorder or because of orbital signs (exophthalmos, pain, etc.). ...
Anand Sanjeev - - 2014
Background: The purpose of the study was to correlate the provisional diagnosis of pericoronal radiolucencies associated with impacted, embedded, or unerupted teeth with the histopathologic diagnosis, and also to emphasize the importance of early detection for better diagnosis and management. Methods: This is a retrospective study involving 18 cases of ...
Lee Robert R Department of Dermatology, Rutgers University - New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey, - - 2014
Chronic lymphedema has a permissive effect with certain types of malignancies, particularly angiosarcomas, in what is known as Stewart-Treves syndrome. The presumed mechanism of this effect is an immunocompromised district of the affected area. Most other cutaneous malignancies have also been described in lymphedematous areas, including basal cell carcinoma, squamous ...
Melo Auremir Rocha - - 2014
Juvenile psammomatoid ossifying fibroma (JPOF) is a histologic variant of an ossifying fibroma. While an ossifying fibroma varies in appearance, it consists of fibrocellular tissue and mineralized material. JPOF is a rare benign lesion; however, it can be extended locally and mimic a malignant tumor. It is considered a specific ...
Balan Preethi - - 2014
Unicystic ameloblastoma (UCA) is a cystic lesion that shows clinical, radiographic, or gross features of an odontogenic cyst, but reveals a typical ameloblastomatous epithelium lining in the cyst cavity, with or without luminal and/or mural tumor growth. This article reports the case of a 22-year-old man with dull intermittent pain ...
Zargaran Massoumeh M Dental Research Center and Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, - - 2014
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with ...
Yoshiyama Akira A Department of Orthopaedic Surgery, Faculty of Medicine, Kyorin University, Mitaka, Tokyo, - - 2014
Lipoma and well-differentiated liposarcoma (WDLS) are two representative lipogenic soft tissue tumors that have similar clinical, radiological, and pathological characteristics. Accordingly, it is difficult to distinguish these tumors preoperatively. Plasma D-dimer levels are associated with the status of tumor progression, and we hypothesized that D-dimer levels could contribute to differential ...
Taha Mohamed S MS Department of Otorhinolaryngology, Faculty of Medicine, Ain Shams University, Cairo, - - 2014
Sinonasal lesions are a heterogeneous group of lesions that span from a tumor to tumor-like nature. Characterization of such cases preoperatively can improve the surgical control and the overall outcome of these patients. In this prospective study, we aimed at evaluation of the role of apparent diffusion coefficient (ADC) in ...
Carbo Alberto I AI From the Department of Radiology, Louisiana State University Health Sciences Center, 1501 Kings Hwy, Shreveport, LA - - 2014
The descending duodenum is a structure with distinct pathologic processes and anatomic relationships that requires a systematic approach to the differential diagnosis. Because of its tubular shape and fixed position in the retroperitoneum, both intrinsic duodenal and juxtaduodenal diseases are capable of producing luminal narrowing and obstruction. Duodenal lesions may ...
Stenner Markus M Department of Otorhinolaryngology, Head and Neck Surgery (MS, MK, CR); and Institute of Pathology, University Hospital of Münster, Münster, Germany - - 2014
We report on a rare case of a laryngeal carcinoma arising in a multifocal pharyngolaryngeal oncocytic papillary cystadenoma (OPC). The disease of a 63-year-old man is well documented by computed and positron emission tomography, histology, and electron microscopy. We could show that an OPC can even develop in the pharynx. ...
Veenstra Michelle Anne MA Department of Pediatric Surgery, Children's Hospital of Michigan, Detroit, Michigan, United - - 2014
Introduction At present, the diagnosis of ulcerative colitis (UC) requires the histologic demonstration of characteristic mucosal inflammatory changes. A rapid and noninvasive diagnosis would be of value, especially if it could be adapted to a simple rectal probe. Raman spectroscopy creates a molecular fingerprint of substances by detecting laser light scattered ...
Kato Yuki Y Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, - - 2014
Cytologic diagnosis of canine histiocytic sarcoma (CHS) can be challenging because neoplastic histiocytes commonly show marked nuclear and cellular atypia and may resemble other pleomorphic malignant round cell tumors. Therefore, even on histopathologic examination, immunostaining is often necessary for a definitive diagnosis. The objective of this study was to validate ...
Sempoux Christine C Christine Sempoux, Service d'Anatomie Pathologique, Cliniques universitaires Saint Luc, Université catholique de Louvain, 1200 Brussels, - - 2014
This practical atlas aims to help liver and non liver pathologists to recognize benign hepatocellular nodules on resected specimen. Macroscopic and microscopic views together with immunohistochemical stains illustrate typical and atypical aspects of focal nodular hyperplasia and of hepatocellular adenoma, including hepatocellular adenomas subtypes with references to clinical and imaging ...
Paggi Silvia S Gastroenterology Unit, Valduce Hospital, Via Dante, 11 - 22100 - Como, - - 2014
Diminutive polyps (<5 mm in diameter) represent the majority of polyps found during colonoscopy; about a half of them are adenomatous, with low risk of advanced neoplasia. Recent studies have demonstrated that cold polypectomy should be considered the recommended approach for resecting diminutive polyps and that cold snaring may be ...
Magro Gaetano G Department G.F. Ingrassia, Azienda Ospedaliero-Universitaria "Policlinico-Vittorio Emanuele", Anatomic Pathology, University of Catania, 95123 Catania, Italy. Electronic address: - - 2014
Myofibroblastoma (MFB) of the breast is a relatively rare, benign stromal tumor arising in the breast of both males and females. Several morphological variants have been recognized in the last two decades, including infiltrating, cellular, fibrous/collagenized, epithelioid/deciduoid-like cell, lipomatous and myxoid variants. Myxoid MFB is an extremely rare variant which ...
Hiyoshi Yukiharu Y Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Japan. Electronic address: - - 2014
Immunoglobulin G4-related disease (IgG4-RD) is a systemic disease characterized by chronic fibrosing inflammation with abundant IgG4-positive plasma cells, and responds well to steroids. Previous reports of IgG4-RD have focused on pancreatic and extrapancreatic including the gastrointestinal tract, however, the colonic IgG4-RD is rare. We herein report the case of a ...
Razavi S M SM Isfahan University of Medical Sciences, School of Dentistry, Department of Oral and Maxillofacial Pathology and Torabinejad Dental Research Center, Isfahan, Iran. - - 2014
Keratocysticodontogenic tumor (KCOT) is one of the most common odontogenic cysts and has a high recurrence rate after various treatment methods. Some studies have been conducted to identify the predictive factors of recurrence. In this study, the clinicopathological and immunohistochemical features of primary and recurrent KCOTs are analyzed, including immunohistochemically ...
Li Yan Xia YX Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China. - - 2014
Esophageal squamous cell carcinoma is a common malignant tumor in recent years, and the key for improving the survival rate is early diagnosis and treatment. Computed virtual chromoendoscopy with the Fujinon intelligent color enhancement (FICE) system was reported to improve visualization of neoplastic and non-neoplastic lesions in gastroscopy and colonoscopy. ...
Kim Minkyu M Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, - - 2014
Clear cell odontogenic carcinoma (CCOC) is a rare jaw tumor that was classified as a malignant tumor of odontogenic origin in 2005 by the World Health Organization because of its aggressive and destructive growth capacity and metastasis to the lungs and lymph nodes. We report a case of a 66-year-old ...
Fernandez-Bussy Sebastián S Division of Interventional Pulmonology, and - - 2014
Endobronchial chondromas are rare benign tumors. They may be part of the Carney triad; however, isolated endobronchial chondromas can occur in the larynx, trachea, and bronchi. We report a case of an endobronchial chondroma in a 61-y-old man with an incidental 5-mm endobronchial polypoid lesion at the proximal left main ...
Kumar Subhash S Department of Radiodiagnosis, All India Institute of Medical Sciences, Patna, Bihar, - - 2014
Pycnodysostosis is a rare autosomal recessive disorder caused by mutations in the cysteine protease Cathepsin K gene located on chromosome 1q21. It has a well characterized skeletal phenotype which include short stature, generalized increased bone density with propensity of fractures, open calvarial sutures and fontanelle, dental abnormalities, obtuse mandibular angle, ...
Saha M M Dr Madhusudan Saha, Associate Professor of Gastroenterology, North East Medical College, Sylhet, - - 2014
Crush smear cytology, commonly used for central nervous system lesions was reported to be useful in the diagnosis of GI malignancies. This study was designed to see the accuracy of crush smear cytology in detection of gastrointestinal malignancy in relation to histopathological examination. First 4 or 5 bits of pinch ...
Bose Mohua M Associate Professor, Department of Microbiology, Murshidabad Medical College , Berhampore, West Bengal, India - - 2014
Actinomycosis is a subacute or chronic suppurative bacterial infection caused by filamentous gram positive, anaerobic to microaerophilic non acid fast bacilli primarily of the genus Actinomyces that normally colonize the mouth, colon and vagina. Primary cutaneous actinomycosis is a rare entity and is generally associated with trauma. We report a ...
Bedir Recep R Medical Faculty, Department of Pathology, Recep Tayyip Erdogan University , Rize, Turkey - - 2014
Malignant tumour development within a seborrheic keratosis (SK) is extremely rare. Though the most commonly developed malignant tumour is the basal cell carcinoma (BCC), other tumour types have also been reported in literature. Herein, we will report a superficial type BCC case developed within SK localized in hairy skin of ...
Manigandan T T Department of Oral Medicine and Radiology, Sree Balaji Dental College and Hospital, Bharath University, Pallikaranai, Chennai, Tamil Nadu, - - 2014
Oral mucosal melanoma is a rare malignancy with the tendency to metastasize and locally invade tissues more readily than other malignant tumor of the oral cavity. It occurs approximately four times more frequently in the oral mucosa of the upper jaw usually on the palate or alveolar gingiva. The chameleonic ...
Kuźniewski Rafał R Department of Pharmacognosis, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland. Head of Department: Prof. Irena Matławska - - 2014
The aetiopathology of melanoma is (like in other cancers) a result of environmental factors and genetic predispositions. One of the most important environmental factors which has an influence on melanoma aetiology is exposure to UV radiation. To estimate the activity of selected parameters in melanoma diagnosis. In serum of 25 ...
Milicić Valerija - - 2014
There are 961 new cases and approximately 366 deaths from urothelial carcinoma registered annually in Croatia. Exfoliative urinary cytology has important role in detection of high grade urinary tumors, invasive and in situ lesions respectively. In contrast to cystoscopy and biopsy, cytology is a noninvasive method which is easily repeated. ...
Cabuk Devrim D Departments of Medical Oncology, Kocaeli University Hospital, - - 2014
Synovial sarcoma (SS) is a highly malignant tumor that accounts for 10% of all soft-tissue sarcomas. Primary SS arising from the lung is extremely rare, and the prognosis is poor. We report a case of pulmonary SS presenting with a mass lesion invading the right upper and middle lobes, extending ...
Mondal Santosh Kumar SK Department of Pathology, Medical College, Kolkata, West Bengal, - - 2014
Adrenocortical carcinoma (ACC) is a rare malignancy and cytodiagnosis of this tumor is not routinely encountered by a cytopathologist. Here, we report a case of ACC initially diagnosed by computed tomography (CT)-guided fine needle aspiration cytology (FNAC) with the help of immunocytochemistry. A 48-year-old lady presented with flank pain and ...
van Tilborg A A G AA Department of Obstetrics and Gynaecology, Radboud University Medical Center, Nijmegen, The - - 2014
In many tumor types, angiogenesis is the net result of pro- and anti-angiogenic mediators and correlated with metabolic activity, growth, and degree of malignancy. One of the first discovered anti-angiogenic compounds is angiostatin, a proteolytic fragment of plasminogen. The requirements for in vivo angiostatin generation have not yet been determined. We ...
Rao Qiu Q Department of Pathology, Nanjing Jinling Hospital, Nanjing University School of Medicine Nanjing, - - 2014
Recent studies have demonstrated that cathepsin K seems to be a powerful marker in identifying the microphthalmia associated transcription factor (MITF) family tumors such as renal perivascular epithelioid cell neoplasms (PEComas), alveolar soft part sarcoma, and translocation-associated renal cell carcinomas. However, the expression of cathepsin K in melanocytic lesions has ...
Korgali Esat E 0000-0003-0318-0353 Department of Urology, Cumhuriyet University Medical Faculty, 58140 Sivas, - - 2014
Pheochromocytoma is a rare and usually benign neuroendocrine neoplasm. Only 10% of all these tumors are malignant and there are no definitive histological or cytological criteria of malignancy. Single malignancy criteria are the presence of advanced locoregional disease or metastases. We report a case, with a giant retroperitoneal tumor having ...
Ansarin Habib H Department of Dermatology, Hazrat-e Rasool University Hospital, Iran University of Medical Sciences, Tehran, - - 2014
Xanthoma disseminatum (XD) is a rare benign mucocutaneous xanthomatosis that is classified as a benign non-Langerhans cell histiocytosis. We report a 62-year-old man who presented with widespread yellow-brown papulonodular and tumoral lesions on face, flexors, and trunk. Histopathological features of the cutaneous lesions were typical of XD.
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