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Kumar Subhash S Department of Radiodiagnosis, All India Institute of Medical Sciences, Patna, Bihar, - - 2014
Pycnodysostosis is a rare autosomal recessive disorder caused by mutations in the cysteine protease Cathepsin K gene located on chromosome 1q21. It has a well characterized skeletal phenotype which include short stature, generalized increased bone density with propensity of fractures, open calvarial sutures and fontanelle, dental abnormalities, obtuse mandibular angle, ...
van Tilborg A A G AA Department of Obstetrics and Gynaecology, Radboud University Medical Center, Nijmegen, The - - 2014
In many tumor types, angiogenesis is the net result of pro- and anti-angiogenic mediators and correlated with metabolic activity, growth, and degree of malignancy. One of the first discovered anti-angiogenic compounds is angiostatin, a proteolytic fragment of plasminogen. The requirements for in vivo angiostatin generation have not yet been determined. We ...
Rao Qiu Q Department of Pathology, Nanjing Jinling Hospital, Nanjing University School of Medicine Nanjing, - - 2014
Recent studies have demonstrated that cathepsin K seems to be a powerful marker in identifying the microphthalmia associated transcription factor (MITF) family tumors such as renal perivascular epithelioid cell neoplasms (PEComas), alveolar soft part sarcoma, and translocation-associated renal cell carcinomas. However, the expression of cathepsin K in melanocytic lesions has ...
Zhu Li L Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, - - 2013
Cathepsin D is an aspartic lysosomal endopeptidase present in most mammalian cells. Overexpression of cathepsin D is associated with the progression of several human cancers including melanoma. We examined the expression levels of cathepsin D in 20 primary malignant melanomas, 20 metastatic malignant melanomas, 20 benign nevus pigmentosus and 10 ...
Filitis Dan C - - 2013
The treatment of malignant melanoma with inhibitors targeting the BRAF V600E mutation has demonstrated dramatic clinical and radiographic response with improved progression-free and overall survival in the majority of patients receiving treatment. However, cutaneous adverse effects-from proliferative processes to more classic drug side effects-are increasingly being reported in patients on ...
Sauder Maxwell B - - 2013
BACKGROUND: Tumour necrosis factor (TNF)-α inhibitors represent potent new therapies for severe forms of psoriasis, psoriatic arthritis, and several other immune-mediated disorders. Paradoxical worsening or de novo development of psoriasis has been documented with their use. Palmoplantar pustulosis has been one of the commoner presentations of this unusual side effect. ...
Ozaki Nobuyuki - - 2013
BACKGROUND: Serine protease inhibitor Kazal type 1 (SPINK1) is expressed in normal human pancreatic acinar cells and in a variety of tumors, and binds to the epidermal growth factor receptor (EGFR), mediating cell proliferation through the mitogen-activated protein kinase cascade in pancreatic cancer cell lines. Here, we aimed to assess ...
Zheng Gang G Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, - - 2013
Cathepsin K is consistently and diffusely expressed in alveolar soft part sarcoma (ASPS) and a subset of translocation renal cell carcinomas (RCCs). However, cathepsin K expression in human neoplasms has not been systematically analyzed. We constructed tissue microarrays (TMA) from a wide variety of human neoplasms, and performed cathepsin K ...
Takaoka Hirokazu - - 2013
A 46-year-old man, who had had sinusitis, developed bilateral omalgia, petechiae on his lower extremities and a congested right eye. A blood test detected elevated serum C-reactive protein level. Computed tomography incidentally found an acute lesion of thalamic hemorrhage without neurological symptoms and no specific therapy was given at the ...
Zawar Vijay - - 2012
The fact that the lesions occupied the lines of cleavage proved to be telling.
Soares Eduardo Costa Studart - - 2011
Cysts lined with gastrointestinal or respiratory epithelium are rarely found in the oral cavity. These lesions usually involve the ventral surface of the tongue or floor of the mouth. This article describes a new case of a lingual cyst lined by respiratory epithelium, discussing its clinical relevance, surgical management, and ...
Sethi Yatin - - 2011
Amyloid goiter is an atypical presentation of an already rare disease, amyloidosis, which uncommonly comes across in previous review of literature. A patient presented with respiratory distress, which aroused a dilemma on diagnosis because the presentation mimicked that of malignancy. A high index of attentiveness should be kept whenever amyloid ...
Akilesh Shreeram - - 2011
Infectious pseudotumors are unusual proliferations of histiocytes in response to certain microbial organisms. Occasionally this process may involve large airways, producing a mass lesion that may cause respiratory obstruction. Infectious pseudotumors can be confused with malignancy in their radiologic appearance and clinical presentation. We present a case of an aggressive ...
Raghavendran Krishnan K Department of Surgery, University of Michigan, Ann Arbor, MI, USA. - - 2011
Aspiration of oropharyngeal or gastric contents into the lower respiratory tract is a common event in critically ill patients and can lead to pneumonia or pneumonitis. Aspiration pneumonia is the leading cause of pneumonia in the intensive care unit and is one of the leading risk factors for acute lung ...
Baisi Alessandro - - 2011
Angiosarcoma is a malignant soft tissue tumor usually located in the dermis of the extremities. It rarely involves the respiratory system, or the pleura, and the prognosis is extremely poor. We present the case of a patient who had a primary multifocal angiosarcoma of the pleura with left-sided chest pain. ...
Mak Shiu Ting - - 2011
A 72-year-old gentleman presented with a left upper eyelid mass existing for several years but progressively increased in size over 2 weeks. Clinically the 1.5 × 1-cm firm, pigmented and sessile mass resembles a large wart. Excisional biopsy of the mass reveals a diagnosis of verrucous carcinoma. Verrucous carcinoma rarely ...
Morris Carol J - - 2011
Hepatic cysts are a rare presentation of metastases to the liver and typically have ovarian or neuroendocrine sources. Recently, there has been an increased interest in the identification and treatment of hepatic metastases in patients with malignancies. This is most likely owing to improved imaging and treatment modalities, including radiotherapy, ...
Munday John S - - 2011
Canine viral plaques are uncommon skin lesions that are induced by papillomaviruses (PVs). Plaques are usually of little clinical significance in dogs, although they have been reported rarely to progress to squamous cell carcinoma (SCC). Here is described a 7-year-old mixed-breed dog that developed numerous darkly pigmented plaques up to ...
Carvalho Flávio A - - 2011
Central nervous system lesions are rare causes of respiratory failure. Simple observation of the breathing pattern can help localize the lesion, but the examiner needs to be aware of potential pitfalls such as metabolic or pulmonary alterations. We describe 3 cases in which central neurogenic respiratory failure occurred simultaneously with ...
Nafe Laura A - - 2011
Bronchoalveolar lavage fluid (BALF) collection is a valuable respiratory diagnostic procedure in cats. This study evaluated effects of BALF storage on total nucleated cell counts (TNCCs) and differential cell counts (DCC), cell morphology, and cytological diagnosis. Forty-five research cats with neutrophilic, eosinophilic, and mixed inflammation, and healthy controls were enrolled. ...
Tharwat Mohamed - - 2011
The purpose of the present study was to evaluate cattle and buffaloes with respiratory disorders, determine the extent of the lesions, and assess prognosis. The results were compared with the findings determined following physical examination and at slaughter. Animals were referred to Veterinary Teaching Hospitals because of inappetance, loss of ...
Hadda Vijay - - 2010
Lipoid pneumonia is an uncommon disease caused by the presence of lipid in the alveoli. It is classified into two major groups, depending on whether the lipid/oil in the respiratory tract is from an exogenous (exogenous lipoid pneumonia) or endogenous/idiopathic (endogenous lipoid pneumonia) source. The usual presentation occurs with insidious ...
Kleinpenning Marloes M - - 2010
As different tissue types have distinct capabilities to accumulate protoporphyrin IX, fluorescence diagnosis with aminolevulinic acid-induced porphyrins (FDAP) could be used to discriminate between different types of tissue. Previous results demonstrated higher fluorescence ratios in squamous cell carcinoma (SCC) compared with actinic keratoses (AKs). The lesional : non-lesional fluorescence ratio ...
Palomba Annarita - - 2010
Our aim was to determine whether lymphangiogenesis occurs in the early steps of cancerogenesis of the upper aerodigestive tract. We assessed the number of lymphatics per unit area (lymphatic vascular density [LVD]) and the percent area occupied by the lymphatic vessels (lymphatic vascular area [LVA]) by computer-assisted morphometric analysis in ...
van de Nieuwenhof Hedwig P - - 2011
Lichen sclerosus is considered to be the precursor lesion of vulvar squamous cell carcinoma, of which only 2-5% progress to squamous cell carcinoma. Differentiated vulvar intraepithelial neoplasia (VIN) has been proposed to be the direct precursor lesion, but this is a recently recognized, and a difficult to diagnose, entity, which ...
Fantini F - - 2011
Background  Photodynamic therapy (PDT) is increasingly used in the treatment of basal cell carcinoma (BCC). However, scant information is available about the impact of both patient- and lesion-related characteristics on the effectiveness of therapy. Therefore, on the basis of the current data, it is difficult to draw clear-cut indications to ...
Thorat Manojkumar - - 2011
Background: This paper is the first-ever report, to our knowledge, of a case of generalized primary gingival pseudoepitheliomatous hyperplasia(PEH) with significant periodontal findings in a 23-year-old Indian female patient. It explains the need to differentiate PEH from squamous cell carcinoma in diagnosis and treatment planning. The present article also reviews ...
Shah Amishi Y - - 2010
All other factors being equal, the presence of actinic cheilitis, a pre-invasive malignant lesion of the lips, doubles the risk of squamous cell carcinoma developing in this anatomic area. Various forms of local ablation,immunomodulation and surgical extirpation have been proposed as therapeutic interventions. This paper critically evaluates the available medical ...
Renzi Cristina - - 2010
Advanced squamous cell carcinomas (SCC) of the skin can cause significant tissue destruction and may metastasize. Understanding the determinants of patient delay could help prevent advanced presentation. The purpose of the present study was to examine patient- and healthcare-related factors associated with delay before the detection and treatment of SCC. ...
Jakobiec Frederick A - - 2010
A 72-year-old woman presented with a 3 × 2 × 1-mm right lower eyelid micronodular, whitish solid lesion at the nasal eyelid margin that had caused madarosis. Local excision led to the microscopic discovery of 2 epidermoid cysts, one of which harbored a basal cell carcinoma arising from its orthokeratinizing ...
Khanbabaee Ghamartaj - - 2010
Langerhans cell histiocytosis (LCH) is a rare disorder of Langerhans cell with unknown etiology, which can uncommonly be associated with pneumothorax. A 14-month-old female is presented here who was referred to our center due to acute respiratory distress. Reticulonodular changes with multiple cystic areas were detected in chest X-ray, whilst ...
Odashiro Alexandre N - - 2011
Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in immunocompetent individuals in Brazil. Ocular infection by PCM is rare; however, when infection does occur, the most common ocular sites involved are eyelid and conjunctiva. A 68-year-old white male presented with a 2-month history of a painless, ulcerated, infiltrative and diffuse ...
Chrysovergis A - - 2011
Cylindrical cell papillomas are rare tumours which usually arise in the sinonasal region. We report a case of a nasopharyngeal cylindrical cell papilloma in a 56-year-old man who presented with a four-month history of right-sided hearing loss, otalgia, vertigo and tinnitus. Investigation revealed a soft, nodular lesion obstructing the pharyngeal ...
Kashima Katsunori - - 2010
Primary squamous cell carcinoma of the endometrium (PSCCE) is an extremely rare tumor and little information is available about its treatment and prognosis. We report a case of PSCCE diagnosed with preoperative transvaginal ultrasound guided needle biopsy. A 73-year-old woman presented with prolonged abdominal pain. Her endometrium was found to ...
Franchi Alessandro - - 2011
Sinonasal carcinomas are rare tumors with an aggressive clinical behaviour which frequently pose a number of problems regarding the interpretation of diagnostic findings and the treatment. In addition, in comparison with other malignancies of the head and neck region, an elevated fraction of sinonasal carcinomas can be attributed to occupational ...
Rudkin Adam K - - 2011
Aims To report the distribution of histopathological diagnoses in patients who underwent excision of localised limbal lesions that were clinically suspected to be squamous neoplasia (intra-epithelial neoplasia or squamous cell carcinoma). Methods 162 consecutive patients of a single ocular oncologist underwent an excisional biopsy between 1998 and 2009 for suspected ...
Kurisu Yoshitaka - - 2010
Hepatocellular carcinoma metastasizing to the nasal cavity is rare, but nasal bleeding caused by it is difficult to treat. The reason is that a large majority of patients have a bleeding tendency due to liver cirrhosis. Accordingly, early and correct diagnosis is essential. Case 1, a Japanese man in therapy ...
Tsai Tsung-Ming - - 2010
The association of a seborrheic keratosis with other common cutaneous neoplasms such as basal cell carcinoma and Bowen disease has been reported, but the association between a seborrheic keratotis and a malignant neoplasm with sebaceous differentiation is very unusual. We present a case of two contiguous neoplasms, a seborrheic keratosis ...
Wen Qing-Lian - - 2010
Leiomyosarcoma is one of the most common sarcomas arising in the soft tissue and somatic organs. Pleomorphic leiomyosarcoma (P-LMS) may be easily confused with a malignant fibrous histiocytoma (MFH) as both may share nonspecific morphologic features. It is reported that the larynx is the most common site for a second ...
Sherry K R - - 2010
In the Tayside plastic surgical unit where this study was carried out, regular audits of all excised basal cell carcinomas have taken place routinely every three months for over ten years. A five-year review of excised basal cell carcinomas was undertaken between 1st February 1999 and 31st January 2004. A ...
Vohra Surbhi - - 2010
Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by a unique susceptibility to cutaneous infection by a group of phylogenetically related human papilloma viruses (HPVs). These patients show a defect in cell-mediated immunity specific toward the causative HPVs that lead to lifelong disease. The defect is usually inherited as autosomal ...
Goldberg Leonard H - - 2010
Clinically, actinic keratoses (solar keratoses) are keratotic lesions that occur on chronically sunlight-exposed skin. Histologically, they are epidermal tumors. Presenting with a spectrum of clinical features, actinic keratoses are believed to be predictors and precursors of invasive squamous cell carcinoma. This, the first of a two-part overview, examines the etiology ...
Mills Omie - - 2010
Basaloid follicular hamartoma is a benign lesion of important consideration because it can be mistaken both clinically and histologically for basal cell carcinoma. The formation of basaloid follicular hamartoma has been linked to a mutation in the patched gene, which is part of the same pathway implicated in nevoid basal ...
Leeborg Nicky - - 2010
We report the first case, to our knowledge, of syringocystadenocarcinoma papilliferum with p63-verified squamous differentiation and extensive dermal invasion accompanying in situ components. An 86-year-old woman presented with a neoplasm on the neck, and the intralesional heterogeneity typical of these neoplasms led to an initial diagnosis on needle biopsy favoring ...
- - 2010
'In asymptomatic patients seeking dental care, there is insufficient evidence to determine whether screening by means of visual and tactile examination to detect potentially malignant and malignant lesions alters disease-specific mortality.'
Cudney Nicholas - - 2010
The literature reports an increasing occurrence of carcinoma in the young adult nonsmoking and nondrinking population. With it, this trend brings the potential for new comorbidities. This report discusses one such case in which a 30-year-old woman, 28 weeks pregnant, was diagnosed with a hybrid verrucous carcinoma/squamous cell carcinoma. Several ...
Ku?bicki Lukasz - - 2010
Lesions originating from different types of skin cells differ significantly with respect to their pathologic importance. The aim of this work was to examine as to what extent the differences in the origin are reflected in expression levels of CDK-2 and to investigate whether CDK-2 expression might be considered as ...
Sezer Engin - - 2010
Psoriasiform keratosis is a recently reported unique clinicopathological entity characterized by the appearance of a solitary lesion mimicking seborrheic keratosis, actinic keratosis, or squamous cell carcinoma and histopathologic features closely resembling psoriasis. We report a 74-year-old woman presenting with a solitary, scaly lesion on the dorsum of the left arm ...
Bambao Clarissa - - 2010
Giant condyloma acuminatum is a large, slow-growing, exophytic, cauliflower-like tumor of the external genitalia. It is a histologically benign lesion, largely associated with human papillomavirus infection but with a high recurrence rate. The main differential diagnosis includes verrucous carcinoma. Differentiation between these 2 types of tumors is important with respect ...
Miguens S A SA - - 2010
The aim of this study was to review the cases of mucoepidermoid carcinoma diagnosed at the Stomatology Service of São Lucas Hospital (PUCRS). Medical charts were reviewed focusing on the sex and age of the patients, clinical aspect, anatomic site, signs and symptoms, size and histological grade of the lesion. ...
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