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Hu Yuan-Yuan YY Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. - - 2014
Ameloblastic fibrosarcoma (AFS) is a rare malignant odontogenic neoplasm of the jaw. AFS is characteristically composed of a benign odontogenic epithelium and a malignant mesenchymal component. The posterior region of the mandible is the predominantly occupied site. In the present report, a new case of AFS in a 22-year-old male ...
Pan Jiyong J Department of General Surgery, The Third People's Hospital of Dalian, Dalian, Liaoning 116000, P.R. - - 2014
Schwannomas are slow-growing mesenchymal neoplasms that arise from Schwann cells with low malignant potential. These uncommon neoplasms are nerve sheath tumors that arise at almost any anatomical site. The majority of schwannomas are benign, and few are malignant. The current study presents the rare case of an anal schwannoma that ...
Dong Jinghui J Medical Imaging Center, The 302nd Hospital, Beijing 100039, P.R. - - 2014
Malignant fibrous histiocytoma (MFH) is a tumor that occurs throughout the body as a relatively uncommon entity. The current study presents two cases of primary malignant fibrous histiocytoma of the liver. The first case was of a 67-year-old male who exhibited no symptoms or abnormal physical signs, and in whom ...
Sakurai Urara U *Department of Pathology, Tokyo Metropolitan Geriatric Hospital ∥Department of Surgery, Kudanzaka Hospital †Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan ‡Department of Pathology, Massachusetts General Hospital, Boston, MA §Institute of Pathology, Klinikum Bayreuth, Bayreuth, - - 2014
Gastric neoplasms classified as high-grade dysplasia (HGD) by Western pathologists are frequently diagnosed as tubular adenocarcinoma in Japan. Here, we evaluated the prevalence of submucosal and lymphovascular invasion in a series of 125 endoscopically resected gastric neoplasms. On the basis of Western criteria, the lesions were classified as poorly cohesive ...
Chi Angela C AC Division of Oral Pathology, College of Dental Medicine, Medical University of South Carolina, 173 Ashley Ave., Charleston, SC, 29425, USA, - - 2014
The purpose of this study is to evaluate surface papillary epithelial hyperplasia, a microscopic finding that corresponds to the clinical finding of rough or stippled mucosa, as a predictor of polymorphous low-grade adenocarcinoma (PLGA). We conducted a retrospective review of minor salivary gland neoplasms submitted to our biopsy service from ...
Zhang Zhixu Z Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, People's Republic of - - 2014
The aim of this study was to investigate characteristic CT manifestations of the group of ovarian thecoma-fibroma. 24 patients (26 lesions) presenting with the ovarian thecoma-fibroma were analyzed retrospectively, and the diagnosis were confirmed by pathology after surgery. Our findings included: 22 patients were unilateral, while 2 were bilateral; 12 ...
Lombardi Davide D Department of Otorhinolaryngology, University of Brescia, Piazza Spedali Civili 1, 25100, Brescia, - - 2014
Merkel cell carcinoma is a neuroendocrine tumor that occurs predominantly on the sun-exposed skin, with rare cases in the extracutaneous sites. It represents one of the extremely rare malignant neuroendocrine tumors of the salivary glands. We report a case of primary Merkel cell carcinoma of the right submandibular gland. The ...
Costa Marcos Devanir Silva da MD Departments of 1 Neurosurgery - - 2014
Spinal angiolipomas are rare benign tumors that generally induce slow progressive cord compression. Here, the authors describe a case of sudden-onset palsy of the lower extremities caused by hemorrhagic spinal angiolipoma. An emergent laminectomy was performed to achieve total lesion removal. Follow-up examinations indicated neurological improvement and the absence of ...
Davies Benjamin M BM Departments of 1 Neurosurgery - - 2014
Myofibromas are rare, benign tumors of myofibroblasts. Their occurrence in adults, involving bone outside of the head and neck, is especially uncommon. The authors report the case of a 34-year-old woman who presented with left-sided brachialgia. Magnetic resonance imaging identified an expansile soft-tissue lesion of the C6-7 facet joint. En ...
Houbara Seiji S *All authors are affiliated with the Department of Plastic and Reconstructive Surgery, Nagasaki University Hospital, Nagasaki, - - 2014
Vascular malformations can mimic malignant tumors, and the coexistence of both types of lesions can limit and interfere with treatment. A consecutive series of vascular malformations that were treated and evaluated in a single institute and cases involving vascular anomalies combined with malignancies or malignancies that were treated as vascular ...
Ahn Dongbin D Department of Otolaryngology-Head and Neck Surgery, Kyungpook National University, Daegu, Korea, - - 2014
Studies of surgeon-performed ultrasound-guided fine-needle aspiration cytology (US-FNAC) have been limited largely to thyroid nodules. This study evaluated the sampling adequacy and diagnostic accuracy of surgeon-performed US-FNAC for a large range of head and neck mass lesions, including lesions of the thyroid, salivary glands, and lymph nodes. The study included ...
Sakhri Linda - - 2014
Tyrosine kinase inhibitors are widely prescribed in thoracic oncology and have excellent responses as a first-line treatment for locally advanced or metastatic lung cancer with epidermal growth factor receptor mutations. The side effects of tyrosine kinase inhibitors are mostly gastrointestinal and dermatological, and are usually resolved after symptomatic treatment. However, ...
Yuh E L EL From the Departments of Radiology and Biomedical Imaging (E.L.Y., C.T.C.) and Neurological Surgery (P.R.W.), University of California at San Francisco, San Francisco, California; San Leandro Medical Center (S.J.P.), The Permanente Medical Group, San Leandro, California; Department of Radiology (G.M.L.), University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Neurosurgery (M.K.), Northwestern University Feinberg School of Medicine, Chicago, Illinois; and Goodman Campbell Brain and Spine (N.M.B.) and Department of Neurological Surgery (N.M.B.), Indiana University, Indianapolis, - - 2014
Peripheral nerve disorders caused by benign and malignant primary nerve sheath tumors, infiltration or compression of nerves by metastatic disease, and postradiation neuritis demonstrate overlapping features on conventional MR imaging but require vastly different therapeutic approaches. We characterize and compare diffusivities of peripheral nerve lesions in patients undergoing MR neurography ...
Hope Thomas A TA Department of Radiology and Biomedical Imaging, University of California San Francisco, 505 Parnassus Avenue - 0628, San Francisco, CA, 94143-0628, USA, - - 2014
The Liver Imaging Reporting and Data System (LI-RADS) was introduced with the goal of standardizing the diagnosis of hepatocellular carcinoma. The 2014 version of LI-RADS incorporates the use of hepatobiliary contrast agents (HBAs) into the diagnostic algorithm, including gadoxetate disodium and gadobenate dimeglumine. Three new ancillary features are introduced: hepatobiliary ...
Risio Domenico - - 2014
Primary colorectal lymphoma represents a rare minority among the colonic neoplasms. Early diagnosis is often difficult because of unspecific symptoms, with subsequent delays in diagnosis and management. We describe a rare case of colonic lymphoma presenting with synchronous liver metastasis. A 70-year-old male with a 6-mo history of vague abdominal ...
Voltaggio Lysandra L Johns Hopkins Medical - - 2014
Interpretation of intestinal mesenchymal lesions is simplified merely by knowing in which anatomic layer they are usually found. For example, Kaposi sarcoma is detected on mucosal biopsies whereas inflammatory fibroid polyp is nearly always in the submucosa. Gastrointestinal stromal tumors (GIST) are generally centered in the muscularis propria. Schwannomas are ...
Wee Aileen A Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, National University Hospital, National University Health System, - - 2014
The differential diagnoses of fine needle aspiration (FNA) biopsy of a well-differentiated hepatocellular nodule (WDHN) in a woman with hepatitis B cirrhosis are discussed. Radiological diagnosis was a large regenerative nodule containing fat.Establish representative sampling.In cirrhosis, differential diagnosis include large regenerative nodule, dysplastic nodule (low- or high-grade), and early to ...
Bertoni Franco F 1University of Bologna 2Villa Erbosa Hospital Bologna, - - 2014
Bone-forming lesions and cartilage-forming lesions are the most common primary tumors of the bone. They are classified according to their biological potential as benign (chondroblastoma, chondromyxoid fibroma, enchondroma, osteochondroma, periosteal chondroma) and malignant (chondrosarcoma, clear cell chondorsarcoma, mesenchymal chondrosarcoma, dedifferentiated chondrosarcoma) and as to their anatomic location (central/intramedullary, or peripheral ...
Wee Aileen A Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, National University Hospital, National University Health System, - - 2014
Focal liver lesions with glandular features encompass inflammatory, hyperplastic, hamartomatous to neoplastic lesions. They can be solid/cystic, solitary/multiple, occurring in a normal/diseased liver. Hepatobiliary entities should be segregated before considering nonhepatobiliary conditions.In small tissue samples such as fine needle aspiration (FNA) or core biopsy, the diagnostic issues are to distinguish/recognize ...
Gao Zu-Hua ZH McGill University, - - 2014
Primary mesenchymal tumors represent a rare subset of hepatic lesions with overlapping spindle cell morphology. These lesions pose unique diagnostic challenges for pathologists as they are infrequently seen in general practice and can be easily mistaken for their benign counterparts or mimickers. In the current era of personalized medicine, precise ...
Lee Dong-Youn DY Samsung Medical Center, Sungkyunkwan University, Seoul, - - 2014
A 43-year-old woman presented with skin rash on the body which had developed 5 years ago. Several years ago she was diagnosed with parapsoriasis. She received phototherapy with some improvement in another hospital. She complained of itching. Skin examination showed multiple erythematous patches and plaques on the body. Skin biopsy ...
Zheng Yan Y Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. - - 2014
Eccrine spiradenoma (ES) is a rare, benign adnexal neoplasm that may easily be mistaken for glomus lesions or angioleiomyoma due to its painfulness and florid vascularization. A 44-year-old male with a blue-colored, nodular tumor on the left knee, present for 10 years, was submitted for diagnosis. Dermatological examination was undertaken, ...
Zhang Xianghong X Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. - - 2014
Photodynamic therapy (PDT) has clinical approval for use as a minimally invasive therapeutic procedure that is able to exert selective cytotoxic activity toward pathological cells, particularly malignant cells. Following a number of recent technological improvements, PDT has been widely applied to the diagnosis and treatment of malignancies, including lung, esophageal, ...
Trindade Felicidade F *Department of Dermatology, Hospital de Cascais Dr. José de Almeida, Lisbon, Portugal; †Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain; ‡Dermatohistopathologische Gemeinschaftslabor, Friedrichshafen, Germany; §Department of Dermatology, Fundación Jiménez Díaz, Madrid, Spain; ¶Department of Dermatology, Hospital Universitário de Coimbra, Coimbra, Portugal; and ‖Department of Pathology, Hospital Infantil Universitario Niño Jesús, Madrid, - - 2014
Angiokeratomas are vascular anomalies in which the clinical, histological, and immunohistochemical characteristics are insufficient to determine whether the lesion is a vascular neoplasm or vascular malformation, and their exact origin is also uncertain. To further clarify the nosology of angiokeratomas, we studied 14 cases. To analyze immunohistochemical characteristics of angiokeratomas ...
Goyal Abha A Cleveland Clinic, Cleveland, - - 2014
Mesonephric remnants, usually located deep in the lateral cervical wall, may become hyperplastic resulting in a florid proliferation. These can be misinterpreted as malignant and confused with endocervical adenocarcinomas. Recent data have shown that PAX2 is diffusely expressed in mesonephric remnants and hyperplasias. PAX8 is a related transcription protein that ...
Narang Vikram V Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, - - 2014
Ovarian-type surface epithelial carcinomas of testis and paratestis are very rare. These tumors develop from mesothelial inclusions or abnormalities in the development of coelomic epithelium. The diagnosis of these lesions can be difficult, both clinically and radiologically, as morphological, immunohistochemical and ultrastructural features overlap with serous tumors arising in the ...
Dalia Samir S Mercy Clinic Oncology-Hematology, Joplin, MO 64804, USA. - - 2014
Dendritic and histiocytic cell neoplasms are rare malignancies that make up less than 1% of all neoplasms arising in lymph nodes or soft tissues. These disorders have distinctive disease biology, clinical presentations, pathology, and unique treatment options. Morphology and immunohistochemistry evaluation by a hematopathologist remains key for differentiating between these ...
Narang Vikram V Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, - - 2014
Hemangioendotheliomas are rare vascular tumors that can arise from soft tissue or bone. The former comprises hemangioma, epithelioidhemangioma, hemangiomatosis and massiveosteolysis or Gorham's disease (which mimics malignantneoplasm due to aggressive osteolytic destruction). The rarer malignant counterparts are epithelioidhemangioendothelioma, hemangioendothelioma and angiosarcoma in increasing order of malignancy. The diagnosis of these ...
V Schönfeld J J Klinik für Innere Medizin, Marienkrankenhaus, Bergisch - - 2014
Colonoscopy is the standard technique in the diagnosis and treatment of colorectal neoplasia, but small adenomas and even advanced lesions can be missed during the procedure. With large scale screening colonoscopy programs installed, information on quality of colonoscopy in primary care is essential, but scarcely available. Over a period of ...
Rajabi Mohammad Taher MT Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences , Tehran , - - 2014
Abstract Background: Orbital and periorbital presentation is rare for malignant peripheral nerve sheath tumors. These tumors are poorly defined spindle cell neoplasms of peripheral nerves and have not been reported to develop in the lacrimal gland to date. Aim: To report a rare presentation of malignant peripheral nerve sheath tumor ...
Hernandez-Prera Juan Carlos JC Department of Pathology, Icahn School of Medicine at Mount Sinai, United - - 2014
Colitis cystica profunda (CCP) is a nonneoplastic condition characterized by misplaced glands deep to the muscularis mucosae of the colon and may be difficult to differentiate from well-differentiated mucinous adenocarcinoma. Absence of dysplasia in CCP usually aids in this distinction. We present a challenging case of CCP in the setting ...
Ozgür Anıl A Department of Radiology, Mersin University School of Medicine, Mersin, Turkey. - - 2014
Mandibular lesions may arise from both odontogenic and nonodontogenic origins (1). Odontogenic lesions are common in the mandible, and imaging features of these lesions are well described in the radiology literature. However, various nonodontogenic pathologies including primary tumors, tumor-like lesions, metastases, infection, vascular lesions, and metabolic abnormalities may also present ...
Hayashi Toshitetsu T Department of Pathology, University Health Network, 200 Elizabeth Street, 11th floor, Toronto, ON, M5G2C4, - - 2014
The adrenal gland is a site of various neoplasms; however, it is rarely involved by sarcomas. We present herein an unusual adrenal neoplasm consisting of epithelioid angiosarcoma and adrenal cortical adenoma. In this report, the authors highlight the diagnostic challenges associated with an epithelioid angiosarcoma occurring in an adrenal cortical ...
Leclercq D D Neuroradiology Department, Pitié-Salpêtrière Hospital, 47-83, boulevard de l'Hôpital, 75013 Paris, France. Electronic address: - - 2014
Pseudotumoral lesions are uncommon but important to identity lesions. They can occur during inflammatory diseases (systemic diseases, vasculitis, demyelinating diseases), infectious, and vascular diseases. Also, in a patient with a treated tumor, pseudo-progression and radionecrosis must be differentiated from the tumoral development. Diagnosis can be difficult on an MRI scan, ...
Sinha R R Department of Dermatology, Chelsea & Westminster Hospital NHS Foundation Trust, 369 Fulham Road, London, SW10 - - 2014
Vemurafenib was the first BRAF inhibitor to be licensed for the treatment of metastatic melanoma. It is associated with a spectrum of cutaneous toxicities including benign and malignant squamous proliferations.(1,2) Treatment of these lesions can be challenging as the lesions may be eruptive and frequent. Effective skin preserving therapeutic measures ...
Maa Hung-Chune HC *Department of Pathology †Medical Research Center ‡Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine §Department and Institute of Life-Science ∥Department of Chemistry ¶Graduate Institute of Basic Medicine, Fu-Jen Catholic University, New Taipei, - - 2014
The sensitivity in cytology diagnosis of malignant metastatic pleural effusion (MMPE) is insufficient nowadays due to the similarity of the reactive mesothelial cells and malignant cells. Vascular endothelial growth factor (VEGF) is one of the key factors in tumor lymphangiogenesis and metastasis. Therefore, the aim of this study was to ...
Lau Darryl D Department of Neurological Surgery, University of California, San Francisco, - - 2014
Malignant peripheral nerve sheath tumors (MPNSTs) are rare, affecting only a small portion of the general population. In many cases, MPNSTs occur in association with neurofibromatosis Type 1 and at times arise secondary to previous radiation therapy (RT). These tumors can be found essentially anywhere a peripheral nerve is present, ...
Choi Jin Woo JW Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, - - 2014
Background and study aims: A diagnostic molecular marker for pre-neoplastic lesions, particularly before polyposis, is still lacking. Lgr5 has been broadly accepted as a marker for intestinal cancer stem cells. The aim of this study was to investigate the monitoring of Lgr5( + ) cells as a useful tool for the early ...
Taylor Steve S Departments of *Pathology and Laboratory Medicine †Hematology and Oncology ‡Surgery §Radiology, Phoenix Children's Hospital, Phoenix, - - 2014
Diffuse malignant peritoneal mesotheliomas in children are uncommon, aggressive tumors with a grave prognosis. We herein report the clinical, radiologic, and pathologic findings of a 16-year-old male. The adolescent presented with a history of abdominal pain, nausea and daily, nonbilious, nonbloody emesis for 3 weeks. Radiographic imaging suggested small bowel ...
Kuwamoto Satoshi S Department of Pathology, Tottori University Hospital, Yonago, - - 2014
Background: Renal carcinomas associated with Xp11.2 translocations/TFE3 gene fusions are rare subtypes of renal neoplasm that predominantly occur in younger individuals. There are very few reports describing the cytologic features of these tumors. Case: A 27-year-old man presented with hematuria and was found to have a mass in the lower ...
Héran F F A. de Rothschild Foundation, Imaging Department, 25, rue Manin, 75019 Paris, France. Electronic address: - - 2014
The term orbital tumor covers a wide range of benign and malignant diseases affecting specific component of the orbit or developing in contact with them. They are found incidentally or may be investigated as part of the assessment of a systemic disorder or because of orbital signs (exophthalmos, pain, etc.). ...
Anand Sanjeev - - 2014
Background: The purpose of the study was to correlate the provisional diagnosis of pericoronal radiolucencies associated with impacted, embedded, or unerupted teeth with the histopathologic diagnosis, and also to emphasize the importance of early detection for better diagnosis and management. Methods: This is a retrospective study involving 18 cases of ...
Lee Robert R Department of Dermatology, Rutgers University - New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey, - - 2014
Chronic lymphedema has a permissive effect with certain types of malignancies, particularly angiosarcomas, in what is known as Stewart-Treves syndrome. The presumed mechanism of this effect is an immunocompromised district of the affected area. Most other cutaneous malignancies have also been described in lymphedematous areas, including basal cell carcinoma, squamous ...
Melo Auremir Rocha - - 2014
Juvenile psammomatoid ossifying fibroma (JPOF) is a histologic variant of an ossifying fibroma. While an ossifying fibroma varies in appearance, it consists of fibrocellular tissue and mineralized material. JPOF is a rare benign lesion; however, it can be extended locally and mimic a malignant tumor. It is considered a specific ...
Balan Preethi - - 2014
Unicystic ameloblastoma (UCA) is a cystic lesion that shows clinical, radiographic, or gross features of an odontogenic cyst, but reveals a typical ameloblastomatous epithelium lining in the cyst cavity, with or without luminal and/or mural tumor growth. This article reports the case of a 22-year-old man with dull intermittent pain ...
Zargaran Massoumeh M Dental Research Center and Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, - - 2014
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with ...
Yoshiyama Akira A Department of Orthopaedic Surgery, Faculty of Medicine, Kyorin University, Mitaka, Tokyo, - - 2014
Lipoma and well-differentiated liposarcoma (WDLS) are two representative lipogenic soft tissue tumors that have similar clinical, radiological, and pathological characteristics. Accordingly, it is difficult to distinguish these tumors preoperatively. Plasma D-dimer levels are associated with the status of tumor progression, and we hypothesized that D-dimer levels could contribute to differential ...
Taha Mohamed S MS Department of Otorhinolaryngology, Faculty of Medicine, Ain Shams University, Cairo, - - 2014
Sinonasal lesions are a heterogeneous group of lesions that span from a tumor to tumor-like nature. Characterization of such cases preoperatively can improve the surgical control and the overall outcome of these patients. In this prospective study, we aimed at evaluation of the role of apparent diffusion coefficient (ADC) in ...
Carbo Alberto I AI From the Department of Radiology, Louisiana State University Health Sciences Center, 1501 Kings Hwy, Shreveport, LA - - 2014
The descending duodenum is a structure with distinct pathologic processes and anatomic relationships that requires a systematic approach to the differential diagnosis. Because of its tubular shape and fixed position in the retroperitoneum, both intrinsic duodenal and juxtaduodenal diseases are capable of producing luminal narrowing and obstruction. Duodenal lesions may ...
Stenner Markus M Department of Otorhinolaryngology, Head and Neck Surgery (MS, MK, CR); and Institute of Pathology, University Hospital of Münster, Münster, Germany - - 2014
We report on a rare case of a laryngeal carcinoma arising in a multifocal pharyngolaryngeal oncocytic papillary cystadenoma (OPC). The disease of a 63-year-old man is well documented by computed and positron emission tomography, histology, and electron microscopy. We could show that an OPC can even develop in the pharynx. ...
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