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Sheth Vaneeta M VM Brigham and Women's Hospital (BWH), Boston, MA, USA, - - 2014
Studies aimed at understanding the pathology, genetics, and therapeutic response of vitiligo rely on asking a single question about 'physician-diagnosed' vitiligo on surveys to identify subjects for research. However, this type of self-reporting is not sufficient. Our objective was to determine if the patient-administered Vitiligo Screening Tool (VISTO) is a ...
Sherman Morris M Department of Medicine, University of Toronto, Toronto, Ontario, - - 2014
All the major liver disease societies have recommended screening for hepatocellular carcinoma (HCC). The target population for HCC screening has been defined by cost-efficacy analyses and by risk scores. Risk scores have been developed for patients with hepatitis B, regardless of the presence of cirrhosis, and for other patients with ...
Cong Xiang X Department of Ultrasound, Qilu Hospital of Shandong University, P. R. - - 2014
Abstract Objective To evaluate and screen for fetal biliary cystic malformation (BCM) associated-ultrasonic key signs or sign-combinations. Methods Thirty cases of fetal abdominal cysts were investigated, followed up and divided into BCM and non-BCM groups. Expression rates of seven fetal BCM-associated ultrasonic signs in the two groups (A: the cyst ...
Nusliha Anwer - - 2014
Familial Adenomatous Polyposis (FAP) is an autosomal dominant condition giving rise to multiple adenomatous polyps in the colon which invariably become malignant by the fourth decade. Congenital hypertrophy of retinal pigment epithelium (CHRPE) is one of its extra intestinal manifestations early in childhood, presents in 90% of FAP population and ...
VandenBussche Christopher J CJ Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Md., - - 2014
Introduction: We previously identified a high level of accuracy among our cytotechnologists (CTs) for identifying nuclear atypia in thyroid fine-needle aspiration (FNA) specimens. Herewith, we present our CT performance at screening for microfollicular atypia. Methods: 8,814 thyroid FNA specimens were identified in our archives, all screened by 1 of 11 ...
Ruocco Eleonora E Department of Dermatology, Second University of Naples, Naples, - - 2014
Sarcoidosis is a systemic granulomatous disease characterized by the presence of non-caseating granulomas. Its etiology remains obscure. A plausible hypothesis suggests that a complex interplay of host factors, infectious processes, and non-infectious environmental factors, matched with a susceptible genetic background, results in a pathway that leads to systemic granulomatous inflammation. ...
Barasoain-Millán Alberto - - 2014
Abstract Pyogenic granuloma, also named lobular capillary hemangioma, is a common proliferative vascular lesion known as a benign condition despite its rapid growth. It may appear in any cutaneous or mucosal surface but is usually restricted to the oral cavity. It is characterized by a friable mulberry-like lesion that can ...
Li Zhe Z Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada ; - - 2014
Survivors of childhood cancer (SCC) who have received radiotherapy to the head, neck, and upper thorax are at higher risk of developing subsequent thyroid malignancies. As part of the post treatment long-term follow-up protocol, the current Children's Oncology Group guideline recommends surveillance by annual palpation, however, thyroid nodules are difficult ...
Castelló Serrano Iván I Institute of Chemical Research of Catalonia (ICIQ), Avinguda del Països Catalans 16, 43007 Tarragona, Spain. gstoica@iciq.es - - 2014
We present herein two colour encoded silica nanospheres (2nanoSi) for the fluorescence quantitative ratiometric determination of trypsin in humans. Current detection methods for cystic fibrosis diagnosis are slow, costly and suffer from false positives. The 2nanoSi proved to be a highly sensitive, fast (minutes), and single-step approach nanosensor for the ...
Fukuoka Junya J Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, - - 2014
Histopathological diagnosis of interstitial pneumonia (IP) requires experiences and is often challenging for general surgical pathologists. In its context, accurate recognition of histopathological usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP) patterns along with separation of idiopathic IPs from ones associated with hypersensitivity pneumonia and systemic connective tissue disease ...
McLaughlin Carol T CT 1 Division of Breast Imaging, Department of Radiology, University of Michigan Health System, C415 Med Inn Bldg, SPC 5842, 1500 E Medical Center Dr, Ann Arbor, MI - - 2014
OBJECTIVE. The purpose of this study was to establish the upgrade rate of atypical ductal hyperplasia (ADH) diagnosed by stereotactic vacuum-assisted core needle biopsy for calcifications detected by digital mammography as compared with film-screen mammography. MATERIALS AND METHODS. A retrospective record search identified 101 cases of ADH. Criteria included women ...
Goldsmith Stuart M SM Dermatology, Emory University School of - - 2014
Current clinical approaches to melanoma diagnosis have not been associated with a decrease in mortality from this cancer. The components of the new approach presented are, first, a screening examination to look for any lesion that stands out because of being dark, different, or changing; second, when a single lesion ...
Campbell Naomi M NM Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA, - - 2014
Intraductal papillary mucinous neoplasms (IPMN) are being diagnosed with increasing frequency, necessitating an algorithm to help stratify patients into low- and high-risk groups, for follow-up versus more invasive evaluation. New evidence concerning their natural history and overall risk of malignancy has emerged since the 2006 International Association of Pancreatology consensus ...
Sonne-Holm Emilie E Ortopædkirurgisk Afdeling, Hvidovre Hospital, Kettegård Allé 30, 2650 Hvidovre, Denmark. - - 2014
Hereditary multiple cartilaginous exostoses is a syndrome characterised by the development of multiple osteochondromas. The diagnosis is typically made around the age of 12 years, and the prevalence is estimated at 1:50,000. During skeletal growth, the osteochondromas are benign, but in adult life malignant transformation into chondrosarcomas can occur. This ...
- - 2014
Adrenal pheochromocytomas are rare neuroendocrine tumours, however their prevalence is probably underestimated - in some series 50% were diagnosed at autopsy. The clinical presentation varies among patients, that is why diagnosis might be difficult to establish. Pheochromocytoma may coexist with paraganglioma and when paraganglioma is diagnosed, the patient should be ...
Plovanich Molly M Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass., - - 2014
Pyogenic granuloma, also known as lobular capillary hemangioma, is a common benign vascular proliferative lesion that can present at any age on the skin or mucous membranes. Most lesions do not exceed 2 cm, but there are a handful of giant cutaneous pyogenic granulomas that have been reported, often in ...
Lad Deepesh D Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012 - - 2014
The differential diagnosis of pyrexia, lung nodules and granulomas includes tuberculosis, vasculitis and rarely a malignancy. In countries where tuberculosis or histoplasmosis is endemic, these are the first consideration and often ruled out by microbiological investigations. Vasculitis like granulomatosis with polyangitis (Wegener's granulomatosis), Churg strauss syndrome and sarcoidosis, which are ...
Asija Amit A Department of Internal Medicine, University of Mississippi, Jackson, - - 2014
The incidental detection of solitary pulmonary nodules and ground-glass nodules has increased substantially with the use of computed tomography as a diagnostic modality and is expected to rise exponentially as lung cancer screening guidelines are more widely implemented by primary care physicians. The lesions should then be classified as low, ...
Freesmeyer Martin M Clinic of Nuclear Medicine, Jena University Hospital, Bachstraße 18, 07743, Jena, Germany, - - 2014
The role of (124)Iodine-PET/US Fusion technique is demonstrated in a 52-year-old woman with De Quervain's subacute thyroiditis. A small and adversely located lesion not detected by thyroid scintigraphy could be unambiguously matched with a hypofunctional PET finding. The presented case supports the clinical potential of PET/US Fusion technique in thyroid ...
Lin Martin Hsiu-Chu MH Department of Neurosurgery, Chung Gung Memorial Hospital , Chiayi , - - 2014
A 23-year-old male presented with a parasellar lesion which was suspected as disseminated intracranial germ cell tumour. The diagnosis of germinoma was made using immunohistochemistry from percutaneous trans-foramen ovale biopsy. This report describes the role of neuronavigation-guided biopsy through the foramen ovale for lesions in the parasellar region.
Antonescu Cristina R CR Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, - - 2014
Epithelioid hemangioma (EH) is a benign neoplasm with distinctive vasoformative features, which occasionally shows increased cellularity, cytologic atypia, and/or loco-regional aggressive growth, resulting in challenging differential diagnosis from malignant vascular neoplasms. Based on two intraosseous EH index cases with worrisome histologic features, such as the presence of necrosis, RNA sequencing ...
Lester S Reid SR Postgraduate Resident, Department of Periodontics, Louisiana State University Health Science Center School of Dentistry, New Orleans, LA, - - 2014
This study investigated the demographic, clinicopathologic, and histopathologic findings of lesions diagnosed as peripheral giant cell granuloma (PGCG) by the Louisiana State University Oral Pathology Biopsy Service from 1974 to 2011. Clinical, demographic, and histopathologic evaluation was completed for 279 cases. A follow-up questionnaire was mailed to all surgeons who ...
Choi Hwan Jun HJ From the Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University, Cheonan, - - 2014
Generally, dermoid and epidermoid cysts arise as a result of incomplete separation of the neuroectoderm from the superficial ectoderm with displacement of ectodermal elements along their lines of fusion during development. Dermoid cysts of the posterior head are rare lesions composed of epidermal and mesodermal elements. Furthermore, dermoid cysts in ...
Parwani Simran - - 2014
Localized overgrowths of gingiva such as peripheral fibroma, peripheral ossifying/cementifying fibroma, pyogenic granuloma and peripheral giant cell granuloma belong to a common group of lesions designated as focal reactive overgrowths (FROG). These growths are reactive in nature. They occur in response to chronic, low grade irritation caused by plaque or ...
Maeda Sergio Setsuo SS Disciplina de Endocrinologia, Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, - - 2014
Objective The objective is to present an update on the diagnosis and treatment of hypovitaminosis D, based on the most recent scientific evidence. Materials and methods The Department of Bone and Mineral Metabolism of the Brazilian Society of Endocrinology and Metabology (SBEM) was invited to generate a document following the ...
Sowmya S V SV Senior Lecturer, Department of Oral Pathology & Microbiology, Faculty of Dental Sciences, MS Ramaiah University of Applied Sciences, Mathikere, Bengaluru, Karnataka, - - 2014
Vegetable granuloma (VG) or pulse granuloma is an enigmatic lesion in terms of its designated nomenclature and etiopathogenesis. It is less often reported in the walls of inflammatory and developmental odontogenic cysts. It can present different histological characteristics, possibly related to the length of time in the tissue and its ...
Nakada Takeo T Department of Thoracic Surgical Oncology, Thoracic Center, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, - - 2014
Objectives: We aimed to identify high-resolution computed tomography (HRCT) features useful to distinguish the anaplastic lymphoma kinase gene (ALK) fusion-positive and negative lung adenocarcinomas.Methods: We included 236 surgically resected adenocarcinoma lesions, which included 27 consecutive ALK fusion-positive (AP) lesions, 115 epidermal growth factor receptor mutation-positive lesions, and 94 double-negative lesions. ...
Muthusamy Karthik K Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, - - 2014
Fucosidosis is a rare lysosomal storage disorder due to deficiency of fucosidase enzyme, with around 100 cases reported worldwide. Here, we describe the clinical and imaging features in two siblings with fucosidosis. An 8-year-old girl presented with global developmental delay, followed by regression of acquired milestones from 3 years of ...
Dhawan Amit Kumar AK Department of Dermatology & STD, UCMS & GTB Hospital, Dilshad Garden, Delhi, 110095 - - 2014
Angiokeratoma of vulva is a relatively rare lesion which is occasionally misdiagnosed as melanoma, pyogenic granuloma, seborrheic keratosis, or genital warts. We report a case of vulvar angiokeratomas which were diagnosed and managed as genital warts. All asymptomatic dull red-colored papules over vulva should be subjected to astute clinical and ...
Orenstein Jan Marc JM Department of Pathology, George Washington University , Washington, DC , - - 2014
Abstract The so-called "malignant fibrous histiocytoma (MFH)" has become progressively more enigmatic since entering the soft tissue tumor field, based on tissue culture studies performed almost 50 years ago. It inexplicably evolved from an exceedingly common soft tissue diagnosis into a problematic diagnosis. Because of the conundrum, clinicians require that ...
Lakshmanan Prakash Manikka PM Department of Radiology, Mahatma Gandhi Medical College & Research Institute, Pondicherry, - - 2014
Splenogonadal fusion is a rare congenital anomaly. We present the case of a 6-year-old boy who presented with a left inguinoscrotal swelling. With a clinical diagnosis of left congenital inguinal hernia the patient was taken up for explorative laparotomy where a transperitoneal band was noted adherent to the left testis. ...
Riehl Jessica - - 2014
This case series characterizes the clinicopathologic features and treatment of oral pyogenic granuloma in 8 cats. The cats reported here were patients originating from collaborative efforts at an academic clinical teaching hospital and a specialty dentistry/oral surgery referral practice. Although the initial biopsy results were variable, in all cases the ...
Kocher Neil J - - 2013
A 35-year-old man presented with a painless left scrotal mass. Pathologic examination after orchiectomy revealed splenogonadal fusion. Splenogonadal fusion is an exceptionally rare, typically benign, congenital anomaly. Splenogonadal fusion should be included in the differential diagnosis of a left-sided testicular mass.
von Holstein Sarah Linéa SL Faculty of Health and Medical Sciences, University of Copenhagen, - - 2013
Tumours of the lacrimal gland are rare, but the prognosis may be grave. To date, no population-based incidence and distribution data on lacrimal gland tumours exist. In addition, almost nothing is known about the genetic profile of epithelial tumours of the lacrimal gland. We collected specimens and clinical files on ...
Hwang Michael J - - 2013
Mammary analogue secretory carcinoma (MASC) is a recently described malignancy of the salivary glands characterized by an ETV6-NTRK3 (EN) fusion gene. Morphologically, MASC is sometimes difficult to distinguish from acinic cell carcinoma. Consequently, identifying the chromosomal translocation is essential for diagnosis. We present a case of parotid gland MASC in ...
Massey Gene M - - 2013
Facet cysts are a relatively common source of neural compression in the lumbar spine. Open decompression and fusion are frequently used to treat the stenosis and instability associated with this pathology. Recently, anterior lumbar interbody fusion (ALIF) has increased in popularity for the treatment of lumbar degenerative conditions. ALIF may ...
Xu Chen - - 2013
The maxillofacial region develops during 3 to 8 weeks in an embryo. The process involves neural crest cell migration and proliferation as well as facial protrusion jointing and fusion. The maxillofacial region is one of the predilection sites of congenital malformations. We treated a 5-year-old Chinese boy with abnormal development ...
Oliveira André M - - 2013
USP6 (also known as TRE17) is a ubiquitin-specific protease that was identified as an oncogene in transfection experiments with Ewing sarcoma DNA 2 decades ago. Until recently, little was known about USP6 function and mechanisms of oncogenic activation. The identification of USP6 fusion genes in aneurysmal bone cyst (ABC) and, ...
Sheen Jae Jon JJ Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of - - 2013
Synovial cyst on prevertebral space of C1-2 joint is rare but may be associated hemorrhagic event. We describe a case of a 72-year-old woman who presented with sudden severe headache in her left occipital area with dyspnea. She had rheumatoid arthritis for 14-years. Large hemorrhagic cystic mass was seen around ...
Flucke Uta - - 2013
Chondroid lipomas are benign adipose tissue tumours. Their rarity and peculiar morphology can lead to misinterpretation, especially in small biopsies. Based on a recurrent translocation t(11;16)(q13;p13), the C11orf95-MKL2 fusion gene has been found in a few cases. Therefore, it seemed appropriate to look for this fusion gene in a larger ...
Grimm Nathan L NL Department of Orthopaedics, University of Utah School of Medicine, Salt Lake City, UT, - - 2013
Osteochondritis dissecans (OCD) has been defined as a localized process in which a focus of subchondral bone and adjacent articular cartilage separates from the surrounding bone. With the knee being the most common location for OCD development and the propensity for this lesion to be found in those who participate ...
Hiramoto Nobuhiro - - 2013
We report the case of a patient in whom the diagnosis of Ewing sarcoma arising from a soft tissue was made after successful treatment of diffuse large B-cell lymphoma. A 65-year-old woman presented with a rapidly growing mass in her left scapular region 8 years after successful chemotherapy with the ...
Zhang Yong - - 2013
Splenogonadal fusion is a rare congenital anomaly where the spleen is attached to either testicular or ovarian tissues. In present case, splenogonadal fusion presents as a large mass consciously connected to atrophic testis in left scrotum. The diagnosis of splenic gonadal fusion relies on radiologic and pathologic findings. Uniform density ...
Rudzinski Erin R - - 2013
The International Classification of Rhabdomyosarcoma (ICR) has provided diagnostic criteria for rhabdomyosarcoma (RMS) and formed the basis of histologic risk stratification since its publication in 1995. However, the recognition of new variants of embryonal rhabdomyosarcoma (ERMS), shifts in the diagnostic criteria of alveolar rhabdomyosarcoma (ARMS), the increasing use of myogenin ...
Mun Jong Hyeon - - 2012
The pathogenesis of juxtafacet cysts is closely related to degenerative instability of the lumbar spine and degenerative changes in the ligamentum flavum and the facet joint. A 56-year-old man presented with severe right thigh pain and numbness for 1 month after a laminar fracture of the L4 spine. Magnetic resonance ...
Groch Kátia R - - 2012
Skeletal tissues of 49 humpback whales Megaptera novaeangliae that stranded between 2002 and 2011 along the Abrolhos Bank seashore and its adjacent waters in Brazil were studied. Twelve (24.5%) animals presented pathological changes in one or more bones. Degenerative changes and developmental malformations were most frequent (10.2% each), followed by ...
Gurjar Hitesh Kumar HK Department of Neurosurgery, CN Centre, All India Institute of Medical Sciences, New Delhi, - - 2012
 Aneurysmal bone cysts are rare occurrences in the cervical spine. Surgical treatment in pediatric patients is a challenge. Complete tumor resection offers the best chance for cure.  Diagnosis and surgical management of an expansile aneurysmal bone cyst of the cervical spine involving all three spinal columns in a 10-year-old boy. ...
Taweevisit Mana - - 2012
Abstract Genitourinary tract malformations casusing hydrops fetalis are rare. The authors report a case of a female delivered at 32 weeks gestational age following a prenatal diagnosis of an abdominopelvic cystic mass with hydrops fetalis. The neonate was persistently hypoxic with unstable cardiovascular status and survived only 7 days. At ...
Tajiri Takuma - - 2012
To help pathologists avoid misdiagnosis of intraductal neoplasms arising from the pancreatobiliary system, we report two cases that illustrate diagnostic pitfalls. The first is of a 66-year-old man who complained of appetite loss. An early examination led to a diagnosis of intraductal papillary mucinous neoplasm. Macroscopically, a multilocular cyst without ...
Puffer Ross C - - 2012
OBJECTIVE: Previously we reported anterior decompression of C1-2 synovial cysts and subsequent posterior fusion in a large series. Although the surgical morbidity and mortality were acceptable, prior reports of stand alone C1-2 fusion with resolution of cyst compression presumptively by correction of joint instability were intriguing and obviated the need ...
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