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Schlachetzki Johannes Cm JC Department of Molecular Neurology, Friedrich-Alexander Universität Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, - - 2014
Purpose: Parkinson's disease (PD) is characterized by striatal synaptic deafferentation followed by dopaminergic cell death in the substantia nigra pars compacta. Not only degenerative, but rather regenerative, compensatory changes at distant sites of the primary lesion may occur in PD. The aim of the study was to analyze the temporal ...
Cacciatore Matilde M Departments of Oncology and Pathology, Treviso, - - 2014
Epithelioid mesenchymal malignancies represent a major diagnostic challenge. Epithelioid morphology can be observed in a variety of soft tissue neoplasms, however there exist specific subtypes in which an epithelioid apperance constitutes the most distinctive morphological feature. Moving from epithelioid sarcoma of Enzinger (the prototype of sarcoma with epithelioid morphology), this ...
Hasegawa Mizue M 1Department of Respiratory Medicine, Tokyo Women's Medical University, Yachiyo Medical Center, - - 2014
An 80-year-old man underwent right upper lobectomy for the resection of multiple cysts accompanied by a nodule. The pathological diagnosis was adenocarcinoma with surrounding atypical epithelial cell proliferation in a Type 1 congenital cystic adenomatoid malformation/congenital pulmonary airway malformation. There was epidermal growth factor receptor mutation in the adenocarcinoma and ...
Kundu S S SS Dr Shyam Sundar Kundu, Assistant Professor, Department of Radiology and Imaging, National Institute of Cancer Research and Hospital (NICRH), Mohakhali, Dhaka, - - 2014
Synovial sarcoma (SS) in the neck is a very rare condition. Here we report a case of poorly differentiated synovial sarcoma in the neck of a 20 years old male patient presented with painless swelling in thyroid gland region. Initially he was diagnosed as thyroid mass clinically, by imaging and ...
Fisher Cyril C Royal Marsden Hospital, London, United - - 2013
Aggressive (deep or desmoid-type) fibromatoses are locally infiltrative collagen-forming tumours with potential for recurrence but not metastasis. They exert their clinical effects primarily in relation to location and have variable biological behaviour. In sporadic cases there are somatic mutations in the β-catenin (CTNNB1) gene on 3p21, resulting in immunohistochemically demonstrable ...
Vellutini Eduardo Arnaldo Silva EA Department of Neurosurgery, Hospital do Servidor Público Estadual de São Paulo, IAMSPE , São Paulo , - - 2013
Intracranial epidermoid cysts (ECs) are rare, histologically benign, slow-growing, congenital neoplasms of central nervous system that may arise from retained ectodermal implants. Malignant transformation of an EC to squamous-cell carcinoma is rare; only 13 cases have been reported. We present the case of a 42-year-old woman presenting with left hemiparesis ...
Rammeh S - - 2013
Tailgut cyst (TGC), also called retrorectal hamartoma, is a rare congenital lesion arising from persistent remnants of the postanal gut. Malignant transformation of TGC is exceedingly uncommon. We report herein the clinicopathologic features and the follow-up of a new case of a TGC with adenocarcinomatous transformation occurring in a 61 ...
Imchen Sutsungkokla S Department of Skin and VD, PGIMS, Rohtak, Haryana, - - 2013
Giant congenital melanocytic nevi are rare congenital disfiguring benign neoplasms with a risk of transformation to malignant melanoma. They often present with various extra-cutaneous features. Here, we describe a case of giant melanocytic nevus with developmental dysplasia of bilateral hip, a novel association.
Seo Ill Young IY Departments of Urology and Pathology, Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, - - 2013
Primary sarcoma of the penis has an extremely low incidence, and its diagnosis and treatment are unclear. A 55-year-old man presented with an oval-shaped mass of the glans penis, which was treated by a wide excision. The pathologic result revealed an undifferentiated high-grade sarcoma, which was diagnosed as a pleomorphic ...
Falkenstern-Ge Roger Fei - - 2013
Pulmonary sarcomas overall are very uncommon and comprise only 0.5 % of all primary lung malignancies. The diagnosis is established only after sarcoma-like primary lung malignancies and a metastatic extrathoracic sarcoma have been excluded. Synovial sarcoma accounts for ~8 % of soft-tissue sarcomas. Synovial sarcoma arising from the pleura has rarely been ...
Aggarwal Ekta E Department of Oculoplastics and Ocular Oncology, Vasan Eye Care and L.V. Prasad Eye Institute, Hyderabad, India. Electronic address: - - 2014
Orbital granulocytic sarcoma (chloroma), a rare tumor of immature myeloid cells, has nonspecific clinical and radiological features that make it a diagnostic challenge. Light microscopy and confirmation by immunostaining aid in the diagnosis. Knowledge of this entity is important because early diagnosis and prompt treatment are associated with better prognosis. ...
Dost F F University of Queensland, UQ Centre for Clinical Research, Herston, Australia; University of Queensland, School of Dentistry, Brisbane, - - 2013
This study describes the predictive value of oral epithelial dysplasia (OED) grading as an indicator for malignant transformation and progression. The records of an Australian-based pathology laboratory were searched for oral mucosal biopsies with a dysplastic or malignant diagnosis. Examination for an association with progression and malignant transformation without reinterpretation ...
Kim Junhyung - - 2013
Synovial sarcoma is a rare malignant tumor of the spine. This tumor may present as a painless mass of the spine or slowly enlarge, causing pain or neurologic deficits. As it is difficult to differentiate this lesion from other soft tissue tumors, synovial sarcoma requires histologic confirmation for definite diagnosis. ...
Singh Manuraj - - 2013
Clear cell sarcoma (CCS) is a rare soft tissue sarcoma that shows melanocytic differentiation and typically presents in the distal extremities of young adults. A subset of CCS also occurs within the gastrointestinal tract, including a histologic variant rich in osteoclast-type giant cells. Although these tumours are also S100 protein ...
Choi Chang-Min - - 2013
Purpose:To study chest computed tomography (CT) in tyrosine kinase inhibitor (TKI) treatment of epidermal growth factor receptor (EGFR)-mutant adenocarcinoma.Materials and Methods:This retrospective study was approved by the institutional review board. Informed consent was waived. One hundred thirty consecutive patients with stage IV adenocarcinoma and EGFR mutations at a single tertiary ...
Jacob Sunitha S Departments of Pathology & Medical Gastroenterology, Bahrain Specialist Hospital, Juffair, Manama, - - 2013
A 71-year-old female patient was admitted with intractable diarrhea and abdominal distention following several courses of broad spectrum antibiotic therapy. Colonic biopsy revealed pseudomembranous colitis with foci of signet ring cell (SRC) change. The SRCs possessed bland nuclei and were confined to the basement membranes of the crypts with no ...
Goel Arvind - - 2013
The review summarizes new observations of key roles for circulating angiogenic factors in diagnosing, managing, and treating preeclampsia. Alterations in circulating angiogenic factors (soluble fms-like tyrosine kinase-1 and placental growth factor) in preeclampsia correlate with the diagnosis and adverse outcomes, particularly when the disease presents prematurely (<34 weeks). Measurement of ...
Carvalho Maria Isabel - - 2013
The epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor which has been shown to have an important role in human breast cancer. Its role appears to be associated with increased angiogenesis and metastasis. In order to clarify its role in canine mammary tumours (CMT), 61 malignant neoplasms ...
Samaka Rehab M - - 2013
Trichoepithelioma (TE) is a benign tumor of follicular origin that presents as small, skin-colored papules predominantly on the face. When more than one family member is affected, the disease is known as multiple familial trichoepithelioma (MFT). It is a rare autosomal dominant (AD) skin disease. Malignant transformation is very rare. ...
Kurdoğlu Başak B Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, - - 2013
Myeloid sarcoma is defined as a tumor mass of immature myeloid cells that may be observed in a variety of locations including bone, skin, lymph nodes and soft tissues. However, oral involvement of myeloid sarcoma is extremely rare. These tumors are considered as specific lesions of acute myeloid leukemia. We ...
Wu Gang - - 2013
To investigate the ability of cytokeratin (CK)-19, galectin-3, human bone marrow endothelial cell (HBME)-1 and tyrosine kinase-type cell surface receptor HER2 (HER-2/neu) to differentiate papillary thyroid carcinoma (PTC) from benign thyroid nodules. Archival specimens of PTC and benign thyroid nodules were included in this retrospective immunohistochemical study. CK-19, galectin-3, HBME-1, ...
Ries Jutta - - 2013
The present study evaluated the relevance of EGFR overexpression in prediction of malignant transformation of oral leukoplakia (OLP). The retrospective study comprised paraffin-embedded tissue samples of OLP that transformed into oral squamous cell carcinoma (OSCC) (n=53) and tissue samples of OLP that did not transform into OSCC (n=45) during a ...
Giorlandino A - - 2013
Sclerosing angiomatoid nodular transformation of the spleen is a rare benign vascular lesion with extensive sclerosis and unknown aetiology. Although its pathogenesis is not clear, it has been postulated that it may represent a peculiar hamartomatous transformation of red pulp in response to an exaggerated non-neoplastic stromal proliferation. However, it ...
Wu Tao - - 2013
We present a case of Ewing's sarcoma and primitive neuroectodermal tumour (PNET) of the prostate. A 29-year-old male presented with difficult defecation and anus distention; on magnetic resonance imaging scan of the pelvis, we found a prostate tumour. A transrectal ultrasound-guided needle biopsy confirmed the diagnosis. The patient underwent cystoprostatectomy ...
Bellevicine Claudio - - 2013
Background: Warthin tumor (WT) is a common parotid lesion reliably diagnosed by fine-needle aspiration (FNA). Worrisome metaplastic changes may occur in WT. Their interpretation as mucoepidermoid carcinoma represents a diagnostic pitfall. Moreover, WT and mucoepidermoid carcinoma may coexist, making this distinction difficult. So it is worthwhile to report unusual WT ...
Ha Yumi - - 2013
Myeloid sarcoma is a solid, extramedullary tumor comprising of immature myeloid cells. It may occur in any organ; however, the invasion of peripheral nervous system is rare. Herein, we report the case of myeloid sarcoma on the brachial plexus. A 37-year-old woman with acute myelogenous leukemia achieved complete remission after ...
Hong S - - 2013
To assess the impact of simple renal cyst (SRC) on hypertension, we evaluated the prevalence of SRC as well as the relationship between SRC and hypertension. Data were obtained from 29 666 participants who underwent general health screening tests in 2006. Only participants who underwent contrast-enhanced computed tomography or abdominal ultrasonography ...
Kunz Manfred - - 2013
Malignant melanoma is a highly aggressive tumour with increasing -incidence and poor prognosis in the metastatic stage. In recent years, a substantial number of reports on individual miRNAs or miRNA patterns have been published providing strong evidence that miRNAs might play an important role in malignant melanoma and might help ...
Agrawal Prachi G - - 2013
Epidermodysplasia verruciformis (EV) is a rare, life-long heritable disease caused due to a unique susceptibility to human papilloma virus. The disseminated verrucous lesions and pityriasis versicolor-like lesions persist from early childhood and can transform into a cutaneous malignancy in a fourth of patients. Malignant transformation into syringoid eccrine carcinoma (SEC) ...
Spaulding Reed R - - 2013
Malignant Fibrous Histiocytoma was historically the most commonly diagnosed soft tissue sarcoma of adults. In 2002, the World Health Organization declassified malignant fibrous histiocytoma as a formal diagnostic entity. They recommended renaming the disease "Pleomorphic Undifferentiated Sarcoma". Current thoughts about the origin of this tumor are being debated. We report ...
Sen Rajeev - - 2013
Chloroma, also called granulocytic sarcoma (GS) or Myeloid Sarcoma, is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myeloproliferative disorders but its appearance may precede the onset of leukaemia. The presence of a chloroma is certainly a sign of poor prognosis. We report a ...
Taghipour Zahir Shokouh - - 2013
Synovial sarcoma is a rare form of malignant tumour and accounting approximately for 8% of all soft tissue sarcomas. Head and neck synovial sarcomas are uncommon and parapharyngeal space involvement is extremely rare. We report a case of synovial sarcoma in the parapharyngeal space of a 13-year-old boy with a ...
Sardesai Vidyadhar R - - 2013
Pseudoepitheliomatous, keratotic and micaceous balanitis (PKMB) is a non-venereal and extremely rare pre-malignant condition characterized by silvery white plaque with micaceous scaling on glans seen in elderly uncircumcised men. Symptoms include phimosis, pain, and interference with sexual activity. Herein we present a young, 40-year-old male with PKMB of 5 years ...
Teng Yao-Shu - - 2013
Synovial sarcoma is an uncommon, aggressive malignant tumor of the soft tissues primarily involving the extremities of young adults. Head and neck synovial sarcoma is rare, and its diagnosis and therapy are still challenging.We report a case of a young patient with synovial sarcoma, clinically masquerading as cystic mass of ...
Craig Jeffrey W - - 2013
Myeloid sarcomas are rare extramedullary solid tumors composed of immature myeloid cells. The clinical presentations of these malignant neoplasms are highly variable, ranging from asymptomatic to localized mass effect. Here, we report an unusual case of myeloid sarcoma of the testis found in association with chronic myelomonocytic leukemia where the ...
Elyamany Ghaleb G Department of Hematology and Blood Bank, Theodor Bilharz Research Institute, Egypt ; Hematopathology, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi - - 2013
Introduction. Granulocytic sarcoma (GS), also known as chloroma or extramedullary myeloblastoma, is a solid tumor composed of primitive precursors of the granulocytic series that include myeloblasts, promyelocytes, and myelocytes. Granulocytic sarcoma is a rare tumor that may develop during acute myeloid leukemia (AML) but less frequently may precede its presentation. ...
Alrumaih Redha R Department of Otolaryngology/Head and Neck Surgery and Communication Sciences, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. - - 2013
Myeloid sarcoma is a rare extramedullary malignant tumor composed of immature myeloid cells. The tumor can affect any part of the body. Involvement of the oral cavity and nasopharynx has been reported in 50 cases. We report a case describing myeloid sarcoma affecting the lateral pharyngeal wall. A 31-year-old Arabian ...
Krasowska Dorota - - 2012
Lichen planus is a chronic mucocutaneous T-cell-mediated disease, the cause of which remains unknown. The first case of lichen planus that transformed into squamous cell carcinoma was reported in 1903. The presented study concerns the case of a 62-year-old woman in whom twice malignant transformation of hypertrophic lichen planus in ...
Bain Earl Eugene - - 2012
Myeloid sarcoma is a rare tumor of immature myeloid cells in an extramedullary site. Myeloid sarcoma may present in a variety of locations; skin is one of the common sites. It may precede or occur concurrently with acute myeloid leukemia, chronic myeloid leukemia, other forms of myeloproliferative disorders/myelodysplastic syndrome or ...
Serra-Guillén C - - 2012
Dermatofibrosarcoma protuberans is the most common skin sarcoma, although its incidence is very low compared with other skin tumors. It presents as a slow-growing indurated plaque on which nodules develop over time. The lesion arises in the dermis but can invade subcutaneous tissue, fascia, muscle and even bone. COL1A1-PDGFB translocation ...
Rao Srinivas Ponnam - - 2012
Ameloblastic fibroma is a rare odontogenic tumor comprising neoplastic epithelial and mesenchymal tissues. This lesion was previously considered to be a benign lesion with very limited recurrence rate and malignant transformation. However, recent reports have suggested that this lesion has the potential for recurrence and malignant transformation. In this brief ...
Wang Chung-Chieh - - 2012
Synovial sarcoma is a malignant soft tissue neoplasm that may arise from a variety of sites in the human body. It is typically characterized by its biphasic histological pattern, but a monophasic type composed entirely of spindle cells also exists. The diagnosis of monophasic synovial sarcoma can be very challenging ...
Scardina G A - - 2012
The aim of this research is to evaluate in vivo the characteristics of microcirculation after taking a biopsy sample from the oral mucosa. 20 patients were recruited to the study and all underwent an oral mucosa biopsy for the excision of benign neoformations. The modifications in the oral microcirculation were ...
Turtay M G - - 2012
Intravenous lobular capillary haemangioma (ILCH), also called intravenous pyogenic granuloma, is a rare benign lesion. These lesions are frequently showed themselves in the veins of the neck and upper extremities of young women. Clinical features are not specific. Ultrasonography can be used for diagnosis and showing additional pathologies such as ...
Calli Aylin Orgen - - 2012
Malignant lymphoma that secondarily involves the cervix is a rare condition and may be difficult to distinguish from follicular cervicitis and small cell carcinoma. Cervical lymphoma is sometimes misdiagnosed on cervicovaginal cytology due to its rarity. We report a case of a cervical lymphoma in a 65-year-old woman, which was ...
Vanelli Paolo - - 2012
We evaluated histologic results for surgical left maze with an high-intensity focused ultrasound (HIFU) energy source. Two patients came to our attention 6 and 48 months, respectively, after ablation concomitant to a valve procedure. Tissue specimens, obtained from the lesion site on the mitral isthmus and from the "box lesion" ...
Kim Eun Young - - 2012
Introduction of endoscopic ultrasound (EUS) to medical practice has brought a huge change in diagnostic algorithm of many gastrointestinal diseases. Addition of EUS-guided fine needle aspiration (FNA) upgraded diagnostic power of EUS. In this focused review series, value of EUS-FNA in the diagnosis of various diseases and tips for getting ...
Wiggermann P - - 2012
Purpose: To evaluate the time dependent changes of microcirculation in hepatocellular carcinoma (HCC) lesions during degradable starch microsphere (DSM)-TACE using contrast enhanced ultrasound (CEUS). Materials and methods: A total of 48 CEUS examinations were performed (1-5 MHz, convex probe) in 6 selected patients who underwent DSM-TACE with EmboCept®S for the ...
Phi Ji Hoon - - 2012
Capillary hemangiomas are common tumorous lesions of the skin and soft tissue in infants. These lesions often involve internal organs and rarely develop in the intracranial space. Because of their rarity, clinical descriptions of intracranial capillary hemangioma have been anecdotal and have not provided a coherent understanding of these lesions. ...
Lee Karen A - - 2012
The objective of our study was to assess the incidence of associated malignancy when microscopic radial scars and microscopic intraductal papillomas are encountered at percutaneous biopsy for lesions that otherwise reveal benign histopathology. A search of the pathology database for the period from December 14, 2006, through December 21, 2009, ...
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