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Results 401 - 450 of 595
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Scott R E - - 1989
The biosynthesis of melanin from tyrosine is reviewed as the basis for assessment of laboratory tests that might potentially aid in the diagnosis and management of patients with malignant melanoma. These tests include qualitative and quantitative assays for the intermediates in metabolism of melanin and catecholamines, enzyme assays, metal ion ...
Schuh J C - - 1989
A congenital benign intraocular melanoma was the cause of extreme buphthalmos in the enucleated right eye of a 7-day-old Charolais-cross calf. The tumour was well differentiated with rare mitotic figures and no evidence of extrascleral nor vascular invasion. Congenital intraocular tumours occur rarely in animals and man. There was no ...
Moseley R P - - 1989
Six patients with neoplastic melanomatous meningitis were studied. The diagnosis of this complication of malignant disease rests on the demonstration of malignant cells within the CSF. The addition of monoclonal antibody immunocytology to conventional techniques significantly improved the diagnostic sensitivity of CSF cytology, allowing for earlier and therefore more effective ...
To K W - - 1989
With an occurrence of approximately 1 in 3000 births, von Recklinghausen neurofibromatosis (NF) is one of the most common inherited human disorders. NF is considered a neurocristopathy, a disorder of neural crest derived cells. One of the complications of NF is the development of neural crest derived malignancies such as ...
Spalević L - - 1989
Various cytologic appearances of malignant melanomas represent a great diagnostic problem in the pathologist's everyday work. The new Pearse concept that the melanoblast/cyte is the APUD cell led the authors to the idea of using Grimelius' silver method, characteristic of APUD cells, in the diagnostic pathologic work of both melanotic ...
Silverman J F - - 1988
A unique case of a cutaneous malignant melanoma arising in a black man with a familial history of neurofibromatosis (von Recklinghausen's disease) is reported. Although neurofibromatosis is believed to be a disorder of neural crest origin that is associated with a number of different malignancies, a definite association of malignant ...
Fijten G H - - 1988
This study reported here was undertaken to determine the probability of malignancy in patients presenting with unexplained lymphadenopathy in primary care practice and to estimate the effectiveness of current referral patterns by family physicians in relation to malignant disease. Clinical characteristics that may be discriminatory for malignant causes were also ...
Berson E L - - 1988
A 69-year-old hyperopic man developed acute night blindness and hallucinations of shimmering lights three years after resection of a cutaneous malignant melanoma. There were no metastatic ocular lesions and he had received no medications. His electroretinogram showed abnormalities comparable to those of patients with congenital stationary night blindness with myopia. ...
Harries M L - - 1988
A 42-year-old man presented with a two-week history of right-sided otalgia, deafness and nocturnal tinnitus. Examination revealed a black mass on the posterior meatal wall. Two years before presentation, he had a malignant melanoma removed from the left hip region. Biopsy of the lesion in the posterior canal wall and ...
Jüttner F M - - 1988
In five patients solitary pulmonary lesions were detected radiographically during routine follow up after malignant melanoma. Surgical removal was done in each case under the tentative diagnosis of metastases. Histologically, two lesions turned out as benign chondroma, one as organized pulmonary infarction and one as bronchogenic carcinoma. Only in one ...
Felding-Habermann B - - 1988
Gangliosides from benign and malignant melanomas and from normal skin of the fish genus Xiphophorus were isolated and analyzed by thin-layer chromatography. Individual ganglioside components were characterized by mapping according to their sialic acid content and by cleavage with neuraminidases. In all three tissues examined, sulfatide and the gangliosides NeuAc-GalCer ...
Myskow M W - - 1988
We report a case of malignant melanoma of the penis. Appropriate staging of these rare cancers is discussed in light of current views of the biology of malignant melanoma arising at other skin sites, and the implications of Breslow thickness for management are considered. There is no good evidence in ...
DiSclafani M - - 1988
An 87-year-old woman, who had undergone cataract surgery and vitrectomy OD two years previously, had a blind, painful right eye secondary to intraocular hemorrhage and glaucoma. At the initial examination, a flat area of darkly pigmented tissue was noted at the wound site of the previous cataract surgery, and uveal ...
Cartwright R A - - 1988
A case-control study utilizing available medical records was carried out to investigate possible links between use of topical benzoyl peroxide for acne, and malignant melanoma. One hundred and fifty nine cases and 213 matched controls were used in the analysis which shows no significant association between the use of benzoyl ...
Paties C T - - 1987
An unusual case of multiple relapsing Spitz nevus (SN) in a patient with pseudohypoparathyroidism is described. It arose initially as a single lesion, and recurred twice as multiple agminated lesions that maintained the same histological pattern as the original SN. Nevertheless, the clinical behavior led to a diagnosis of metastasis ...
Schwab L - - 1987
Malignant melanoma of the eye and adnexa is rare in blacks. A highly unusual malignant melanoma of the tarsal conjunctiva in an adult Ethiopian female, believed to be the first reported in a black patient, is described. Factors that contribute to melanoma in blacks and rates of occurrence are reviewed ...
Kemp K I - - 1987
A simple classification system for reporting mammograms is described, similar in format to a system formerly used for reporting Papanicolaou smears. Class 1 indicates an examination with normal findings. Class 2 indicates findings of a mass or masses that appear to be benign. Class 3 indicates findings of an indeterminate ...
Lin P Y - - 1987
We describe a case of a solitary dermal cylindroma with focal malignant transformation. The scalp tumor measured 3 cm in greatest dimension and was successfully surgically excised. The patient has been followed up for the last two years with no recurrences. Changes of malignant transformation included loss of peripheral palisading, ...
Taylor L M LM - - 1987
The association of malignancy with thrombotic disorders of the arterial and venous systems is well described. To date, however, there are only 23 published case reports of digital gangrene associated with malignancy. During a prospective evaluation of over 700 patients with finger ischemia, there were five patients with finger gangrene ...
Rampen F H - - 1987
A prospective study was undertaken on 489 patients registered between 1981 and 1983 in order to evaluate the correlation between the sex of the patient and the incidence of satellite and in-transit (SIT) metastases. There were 186 males, 12 of whom (6.5%) showed clinical or histopathological evidence of SIT lesions ...
Carey R W - - 1987
ANLL followed a brief period of aplastic anemia in a man treated intensively 4 years and 3 months previously with dacarbazine as "adjuvant" therapy for malignant melanoma. This is the first reported instance in which the latency between drug exposure and onset of leukemia strongly implicates dacarbazine as a leukemogenic ...
Isaacson C - - 1987
Malignant melanoma is common among the whites of South Africa. In the black population, the tumor is much less frequent and occurs predominantly on the lower limb--particularly the sole of the foot. This study brings to light the anomalous situation that among the Eur-African-Malay population (those of mixed ancestry), malignant ...
Zeichner S J - - 1987
In this investigation the efficacy of dental radiography for the detection of occult intraosseous lesions of the face and jaws was evaluated. An analysis of 30 million health insurance records indicated that the period prevalence of malignant lesions was less than 5 cases/million/year, and for benign lesions approximately 100 cases/million/year. ...
Berkelhammer J - - 1987
The objective of the present study was to evaluate the malignant and premalignant lesions that arise in C57BL/6 mice after treatment with 7,12-dimethylbenz(a)anthracene and croton oil. Tissues from 70 treated mice were evaluated by histological and transplantation techniques, and 17 (24%) were found to have malignant tumors. Eleven of the ...
Lindholm C - - 1987
Single cell DNA cytophotometry was used to characterize seven compound, ten intradermal and six Spitz naevi as well as 23 primary cutaneous malignant melanomas. Compound and intradermal naevi were characterized by a smaller nuclear area than both Spitz naevi and malignant melanomas. Tumour ploidy could not be used as a ...
Matous B - - 1987
The excretion of Thormählen positive melanogens (TPM), zincuria, serum dopaoxidase activity of tyrosinase and serum sialic acid were determined in 60 patients with primary and/or metastatic cutaneous melanoma and in 20 healthy persons. On the basis of our results we can recommend the following of TPM urinary excretion and serum ...
Armstrong B K - - 1987
Ultra-violet radiation (UVR) in sunlight is thought to be the main cause of malignant melanoma in lightly-pigmented populations. Individuals with fair skin, fair hair, blue eyes and/or a tendency to burn rather than tan when exposed to the sun are at particularly high risk of melanoma and should be given ...
Brueggemeyer C D - - 1987
Numerous authors have long felt that there is an association between malignancy and membranous glomerulonephritis. Most physicians have not noticed this association since the number of patients that they clinically observe is so low that such a relationship might not be obvious. The present study was undertaken to establish whether ...
Roper J P - - 1986
Desmoplastic malignant melanoma is a rare and highly malignant tumour, which usually occurs in the head and neck. This is demonstrated by a case history of a patient with this lesion on the lower lid, which has not been previously described in the British ophthalmological literature. The lesion often presents ...
Al-Sumidaie A M - - 1986
Peripheral monocyte migration, phagocytosis and lysozyme production has been investigated in 46 patients with colorectal malignancies. The diagnosis of colorectal carcinoma was based on clinical, radiological, and endoscopic examinations and confirmed histopathologically after removal of the tumour. The results were compared with a group of 36 normal healthy controls. Monocytes ...
Kopf A W - - 1986
Characteristics associated with familial compared with nonfamilial malignant melanoma were assessed. These data were obtained from consecutive prospectively completed questionnaires on 1169 cases of cutaneous malignant melanoma. Of these, 69 patients indicated a positive family history for this cancer. Among the various clinical and histological variables compared, those that significantly ...
Williams R A - - 1986
Using a computed video image analysis system, the staining intensity for both neurone specific enolase (NSE) and S100 protein was measured in sections from 19 malignant melanomas and 16 benign melanocytic lesions. The results of this study confirm previous reports that NSE and S100 protein are useful markers for malignant ...
Walsh M Y - - 1986
The incidence of primary cutaneous malignant melanoma is increasing in the developed countries. Cutaneous malignant melanomas diagnosed in our Department over a period of fifty years from 1930 to 1980 were examined to see if there was any change in their histological features. In 1930 and 1955, over 90% of ...
Lakhanpal S - - 1986
To examine the purported association between polymyositis-dermatomyositis and malignant lesions, we identified all patients with histopathologically proven polymyositis-dermatomyositis examined at our institution from 1965 to 1974. For each patient, a control subject was selected, matched for age, sex, race, year and department of clinical evaluation, and geographic area of residence. ...
Rogers G S - - 1986
Stage I cutaneous malignant melanomas between 0.76 and 1.69 mm thick (Breslow measurement) in BANS (upper part of the back, posterior aspects of the arms, posterior and lateral aspects of the neck, posterior aspect of the scalp) areas have been reported to portend a relatively poor prognosis compared to non-BANS ...
de la Monte S M - - 1986
An 84-year-old man with aggressive cutaneous malignant melanoma, which failed to respond to systemic chemotherapy, was electively treated with intralesional bacillus Calmette-Guerin (BCG) immunotherapy. He died with widespread miliary granulomas, most likely representing disseminated BCG infection. However, at autopsy, the patient was found to have a minimal tumor burden and ...
Guldhammer B - - 1986
The malignant intraepithelial proliferations--malignant melanoma level I, bowenoid epithelial dysplasia, and mammary as well as extramammary Paget's disease--may cause differential diagnostic difficulties. We have examined 12 cases of malignant melanoma level I, nine cases of bowenoid epithelial dysplasia, 17 cases of extramammary and five cases of mammary Paget's disease for ...
Bloch T - - 1986
Meckel's diverticulum is a vestigial remnant of the omphalomesenteric duct, which is rarely affected by neoplasia. The authors report the first case of malignant melanoma in Meckel's diverticulum in a middle-aged man without skin or ocular lesions. Five other Meckel's diverticuli were evaluated histologically and by immunoperoxidase technics for neural ...
Bizon J G - - 1986
Malignant melanomas comprise approximately 1.5% of all malignant tumors and one fifth of these will involve the head and neck. The surgeon who operates in this region should be familiar with all aspects of this disease. The most common site of metastasis to the nose and paranasal sinuses is via ...
Soper J T - - 1986
Vulvar dystrophy is a relatively frequent gynecologic problem in postmenopausal women and may cause disabling discomfort. All patients with vulvar dystrophy should be carefully evaluated at the time of initial presentation and during therapy. Biopsies of vulvar lesions should be used liberally to define optimal therapy and to exclude atypia ...
Oates K R - - 1986
Over a period of 13 years 794 patients were seen with confirmed malignant disease at the Centre Medical Evangelique hospital at Nyankunde in north-eastern Zaire, which services a population of approximately 500 000. Malignant disease of the skin accounts for 24% of the total number of malignancies. The commonest tumour ...
Mohs F E - - 1986
Satellites and in-transit metastases do not always forebode the systemic dissemination of malignant melanoma. Five patients with varying numbers of these lesions were successfully treated with the fixed-tissue technique of micrographic surgery. This method permits the excision of these embolic foci with a minimal risk of further dissemination. It is ...
Babel D E - - 1986
Tinea nigra is a superficial mycosis that may mimic serious pigmentary lesions. A lesion recently encountered on the foot was suspected of being a malignant melanoma. Histologic and mycologic studies, done after a biopsy was obtained, demonstrated Exophilia werneckii in the stratum corneum. Tinea nigra should be considered in the ...
McShane D - - 1986
Malignant external otitis was first identified by Chandler in 1968 as a significant otologic entity. Since then its mortality rate has steadily declined. This is due to increased awareness, earlier diagnosis and appropriate antibiotic therapy. A review of five years' experience with this condition at Mount Sinai Hospital, Toronto, is ...
Cassel W A - - 1986
Five patients with advanced malignant melanoma, treated with viral oncolysate, had solitary central nervous system metastases that were removed surgically. Histologic examination revealed striking and significant mononuclear inflammatory cell infiltrates, consisting of a mean of 60% plasma cells and a lesser proportion of lymphocytes at the edges of the lesions, ...
Colver G B - - 1986
Malignant melanoma of the nail is a serious disease with a five year survival rate of between 21% (Booher & Pack, 1957) and 50% (Graham, 1973). The diagnosis of atypical cases ultimately depends on interpreting histological material. We report here a case in which two initial biopsies of the affected ...
Lynch H T - - 1986
The recent increase in incidence of malignant melanoma in many of the "sun belts" of the world has focused intense interest on its etiology. Although sunlight is an important factor, only a fraction of those individuals exposed to significantly large amounts of sunlight develop malignant melanoma. Genetic susceptibility undoubtedly plays ...
Collin J R - - 1986
Four patients with malignant melanoma of the eyelid skin and 14 patients with conjunctival malignant melanoma are presented. Surgery was recommended for eyelid lesions and local excision followed by cryotherapy for conjunctival lesions. One patient with an eyelid skin malignant melanoma died and two patients with extensive malignant melanoma of ...
Dubrow R - - 1986
In an occupational mortality surveillance study, cause-specific mortality patterns by occupation and industry, among Rhode Island residents who died during the period 1968-78, were examined using the age-standardized proportionate mortality ratio (PMR) method. A noteworthy finding was an elevated PMR for malignant melanoma among white males in the printing industry ...
Boullie M C - - 1986
In a family displaying the familial atypical multiple-mole melanoma syndrome, linkage analyses were performed between HLA and an assumed dominant gene respectively determining each of the following affected phenotypes: precursor lesions; cutaneous malignant melanoma (CMM); and precursor lesions or CMM or both. The results suggest that there is a complex ...
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