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Frank Renee R From the Departments of Pathology and Laboratory Medicine - - 2014
Mesothelin (MSLN) is a differentiation antigen found to be overexpressed in intraductal papillary mucinous neoplasms (IPMNs) and is a potential treatment target in pancreatic ductal adenocarcinoma. From institutional archives, 114 cases of resected pancreatic mucinous cysts were identified, including IPMN and mucinous cystic neoplasm (MCN). Immunohistochemical analysis of MSLN was ...
Stoffels Josephine M J JM Department of Cell Biology, University of Groningen, University Medical Center Groningen, The - - 2014
Central nervous system remyelination by oligodendrocyte progenitor cells (OPCs) ultimately fails in the majority of multiple sclerosis (MS) lesions. Remyelination benefits from transient expression of factors that promote migration and proliferation of OPCs, which may include fibronectin (Fn). Fn is present in demyelinated lesions in two major forms; plasma Fn ...
Purysko Andrei S AS From the Abdominal Imaging Section, Imaging Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA, - - 2014
To assess the value of secretin during magnetic resonance cholangiopancreatography (MRCP) in demonstrating communication between cystic lesions and the pancreatic duct to help determine the diagnosis of side-branch intraductal papillary mucinous neoplasm (SB-IPMN). This is an IRB-approved, HIPAA-compliant retrospective study of 29 SB-IPMN patients and 13 non-IPMN subjects (control) who ...
Paini Marina M Marina Paini, Domenico Tamburrino, Department of Surgery, University of Verona, 37134 Verona (VR), - - 2014
Since the first description of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas in the eighties, their identification has dramatically increased in the last decades, hand to hand with the improvements in diagnostic imaging and sampling techniques for the study of pancreatic diseases. However, the heterogeneity of IPMNs and their ...
Okamoto Natsuko N Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, - - 2014
Determination of the niche for early-stage cancer remains a challenging issue. Melanoma is an aggressive cancer of the melanocyte lineage. Early melanoma cells are often found in the epidermis around sweat ducts of human volar skin and the skin pigmentation pattern is an early diagnostic sign of acral melanoma. However, the ...
Kim Moon-Young MY Department of Pathology, Seoul National University Hospital, Seoul, South - - 2014
Congenital pulmonary airway malformation (CPAM) is a rare developmental anomaly of the lung. Here, we report a case of mucinous adenocarcinoma arising in CPAM. A 23-month-old boy underwent a thoracoscopic lobectomy of the left upper lobe of the lung based on a presumptive diagnosis of asymptomatic CPAM, found in antenatal ...
Riveiro-Falkenbach Erica E Departments of *Pathology, and †Dermatology, Hospital Universitario 12 de Octubre, Medical School, Universidad Complutense, Instituto de Investigación I+12, Madrid, - - 2014
: Mycosis fungoides (MF) is the most common type of primary cutaneous T-cell lymphoma. This entity may present with a wide spectrum of clinicopathological manifestations and mimic different dermatoses. Among its histopathological variants, spongiosis is an infrequent finding, and spongiotic microvesiculation is particularly rare. Mucinous deposition is a common event ...
Law Joanna K JK Joanna K Law, Christopher L Wolfgang, Matthew J Weiss, Anne Marie Lennon, Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD 21287, United - - 2014
Branch duct intraductal papillary mucinous neoplasms (BD-IPMN) are pre-malignant pancreatic cystic lesions which carry a small risk of malignant transformation within the cyst. Guidelines exist with respect to surveillance of the cysts using computed tomography, magnetic resonance imaging, and/or endoscopic ultrasound (EUS). There are reports that patients with IPMNs are ...
Chebib Ivan I James Homer Wright Pathology Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, - - 2014
Pancreatic cyst size >3 cm is a worrisome rather than high-risk feature for malignancy based on the 2012 International Guidelines for the management of mucinous cysts. The value of cytology in preoperative evaluation and surgical triage is unclear. All pancreatic cysts >3 cm resected over a 7-year period were evaluated ...
Boyle David P DP Dept of Pathology, Belfast Health and Social Care Trust, Belfast, Northern - - 2014
Stratified mucin producing intraepithelial lesion (SMILE) is an uncommon premalignant cervical lesion with morphological overlap between cervical intraepithelial neoplasia (CIN) and adenocarcinoma in situ (AIS)/ cervical glandular intraepithelial neoplasia. Given the limited literature on SMILE, we aimed to document its frequency and assess the associated pathology in a large series ...
Smith L A LA Gastroenterology, West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom - - - 2014
As the use of cross---sectional imaging increases so does the incidence of asymptomatic pancreatic cysts. Pancreatic neoplastic cysts can be broadly grouped into mucinous lesions and solid pseudopapillary neoplasms, which have malignant potential and serous lesions, which have negligible malignant potential. Non---neoplastic pancreatic cysts such as pseudocysts are not associated ...
Lee Linda S LS Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, - - 2014
Diagnosis of pancreatic cysts remains challenging due to limitations of currently available radiologic and endoscopic tools. The diagnostic approach should focus on identifying mucinous and malignant cysts. Mucinous cysts require further differentiation to allow appropriate management. Although the overall rate of malignant pancreatic cysts is low, it remains higher than ...
Ji Xiao-Qing XQ Department of respiratory medicine, Shandong provincial qianfoshan hospital, Jinan 250014, Shandong Province, - - 2014
Sarcoidosis is a multisystemic disorder of unknown cause that is characterized pathologically by noncaseating granulomas and predominantly affects the lung and the lymphatic system, especially intrathoracic.Diagnosis is based on the association of a compatible clinical and radiological presentation, the presence of characteristic histopathological lesions and the exclusion of other potential ...
Chen Wun-Lin WL Division of Thoracic Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, - - 2014
Cysts and cavities are common radiologic abnormalities. Pulmonary metastasis comprises a rare entity of thoracic cystic diseases. We reported a case of giant cyst at the left anterior mediastinum that was pathologically confirmed as a lung metastasis from previously resected gastric cancer. The cyst was completely removed with wedge resection ...
Surridge Clare A CA Department of Radiology, Greys Hospital, University of KwaZulu Natal, Pietermaritzburg, South - - 2014
Gastric duplication cysts are an uncommon congenital anomaly and rectal bleeding is a rare presentation of a complicated gastric duplication cyst. This case report describes the radiological findings in a child with a complicated gastric duplication cyst.
Akar H H HH Erciyes University School of Medicine, Pediatric Asthma and Allergy Unit, Kayseri, Turkey. E-mail: - - 2014
Prurigo is a condition of nodular cutaneous lesions that itch intensely. Prurigo lesions are divided into acute, subacute and chronic forms that itch intensely. Subacute prurigo (SP) clinically presents as excoriated papules mostly in a symmetrical distribution on the extensor surfaces of the extremities, neck, lower trunk, and buttocks. It ...
Popadić Mirjana M Clinic of Dermatovenereology, Clinical Centre of Serbia, Belgrade, - - 2014
Early detection of basal cell carcinoma (BCC) is of crucial importance, as serious morbidity may result from undiagnosed tumor. To evaluate diagnostic significance (specificity, sensitivity, positive and negative predictive value) of dermoscopic features in BCCs. A prospective observational study was conducted using contact polarized dermoscopy to evaluate the presence of ...
Rehulková Eva E Department of Botany and Zoology, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czech Republic, - - 2014
Two new species of Annulotrema Paperna & Thurston, 1969 were collected from the gills of the African tiger fish, Hydrocynus brevis, from the Gambia River basin in the Niokolo-Koba National Park, Senegal. Annulotrema besalis n. sp. is characterized by having a male copulatory organ (MCO) composed of an arcuate copulatory ...
Oh Hyoung-Chul HC Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, USA, - - 2014
Cyst fluid amylase is a potential marker for pseudocysts and intraductal papillary mucinous neoplasms (IPMN). This study aimed to evaluate the diagnostic role of cyst fluid amylase and to determine the optimal cutoff values of cyst fluid amylase and carcinoembryonic antigen (CEA) for the differential diagnosis of pancreatic cysts. Based ...
Singhi Aatur D AD Pathology, University of Pittsburgh - - 2014
Purpose: Management guidelines for pancreatic IPMNs and MCNs are based on the assumption that mucinous cysts can be accurately distinguished from other pancreatic cystic lesions. Previous studies using surgical material have identified recurrent mutations in GNAS and KRAS in pancreatic mucinous neoplasms. Yet, the diagnostic utility of testing for both ...
Popadić Mirjana M Clinic of Dermatovenereology, Clinical Centre of Serbia, Belgrade, - - 2014
Early detection of basal cell carcinoma (BCC) is of crucial importance, as serious morbidity may result from undiagnosed tumor. To evaluate diagnostic significance (specificity, sensitivity, positive and negative predictive value) of dermoscopic features in BCCs. A prospective observational study was conducted using contact polarized dermoscopy to evaluate the presence of ...
Nucci Marisa R MR Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, - - 2014
Pseudoneoplastic glandular lesions of the cervix continue to be diagnostically challenging for the surgical pathologist. This review covers a select number of these lesions that may be misinterpreted as premalignant or malignant, with an emphasis on those about which Dr Scully has advanced our knowledge. The topics covered include microglandular ...
Kämmerer P W PW Department of Oral-, Maxillofacial- and Plastic Surgery, University Medical Centre of Rostock, Rostock, Germany, - - 2014
The aim of the study was an evaluation of an acetic acid wash and chemiluminescent light system in combination with toluidine blue in order to detect visual identified, potentially malignant lesions. Forty-four patients with 50 oral lesions of primary uncertain visible dignity were included. Next to a clinical examination, a ...
Gu Wei Xiang WX Yong Loo Lin School of Medicine, National University of Singapore, - - 2014
Introduction: Ultrasound-guided fine-needle aspiration cytology (US-FNAC) of thyroid nodules is an important diagnostic procedure. In most hospitals, patients are referred to radiologists for US-FNAC, but this often results in a long waiting time before results are available. Surgeon-performed US-FNAC (SP-US-FNAC) during the initial patient consultation attempts to reduce the waiting ...
Fernández-Esparrach G G Endoscopy Unit. Gastroenterology Department. ICMDM. Hospital Clínic. IDIBAPS. CIBEREHD. Universitat de Barcelona. Barcelona. - - - 2014
Incidental uniloculated cysts are diagnosed more frequently due to the increase in availability of highquality abdominal imaging. The prevalence of incidental pancreatic cysts detected on abdominal imaging is 2.6% and is even higher in old patients. Pancreatic cysts are also found in up to 25% of autopsies, 3% of which ...
Suzuki Shigeki - - 2014
Pulmonary glandular papillomas are rare neoplasms, and their very slow or absent growth over time generally facilitates establishing the diagnosis. In an 84-year-old woman who underwent surgery for sigmoid colon cancer, a growing solitary pulmonary nodule was identified on postoperative follow-up computed tomography. A computer tomography-guided needle biopsy was performed ...
Yergiyev Oleksandr O Department of Pathology and Laboratory Medicine, Allegheny General Hospital, Pittsburgh, Pa., - - 2014
Background: Acinar cell cystadenoma (ACC) is a recently recognized cystic lesion of the pancreas that demonstrates acinar differentiation and is currently believed to behave in a benign fashion. ACC enters the differential diagnosis of pancreatic cystic lesions alongside better recognized entities such as mucinous cystic and intraductal papillary mucinous neoplasms. ...
Wong Chung J E R E JE Radboudumc Nijmegen, Department of Otorhinolaryngology, The Netherlands. Electronic address: - - 2014
We report on a new-born with a congenital mucocele on the anterior dorsal side of the tongue. The presentation as well as the differential diagnosis of congenital oral swellings is discussed. Because of breastfeeding problems the mucinous swelling was incised and drained two days after birth. Immediately after drainage the ...
Chin Joanna Y JY Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, - - 2014
Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a relatively rare cystic neoplasm. Although most IPMNs appear to be benign and may be managed by surveillance, all IPMNs are considered premalignant lesions with malignant potential. As such, current efforts are focused on identifying those neoplasms that are at high ...
Mahapatra Qury S QS Department of Pathology, Army College of Medical Sciences and Base Hospital, Delhi Cantt, Delhi, - - 2014
Sarcoidosis is a systemic granulomatous disease of unknown etiology. Lungs and lymphatics are the principal sites affected by this disease. The disorder is often not suspected by physicians. This was a retrospective study done on 140 transbronchial lung biopsies received for histopathological examination in the Department of Pathology for 1 ...
Ishigami Kousei K Kousei Ishigami, Catherine M Metz, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, United - - 2014
The aim of this article is to clarify diagnostic pitfalls of pancreatic serous cystic neoplasm (SCN) that may result in erroneous characterization. Usual and unusual imaging findings of SCN as well as potential SCN mimickers are presented. The diagnostic key of SCN is to look for a cluster of microcysts ...
Okabe Hidetoshi H Division of Diagnostic Pathology, Department of Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan; Department of Pathology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, - - 2014
Neuroenteric cysts are benign intradural endoderm cysts lined by gastrointestinal (GI) or tracheobronchial epithelial cells. Their malignant transformation is extremely rare and only six cases have been reported. In these cases, tissue lineage of the cystic endoderm cells giving rise to carcinoma was not clearly identified either as respiratory or ...
Gagnière Johan J Johan Gagnière, Aurélien Dupré, Denis Pezet, Emmanuel Buc, Department of Digestive and Hepatobiliary Surgery, Centre Hospitalier Universitaire Estaing, 63003 Clermont-Ferrand, - - 2014
Mucinous cystic adenoma (MCA) of the pancreas is a rare benign cystic tumor with ovarian-like stroma and lack of communication with the pancreatic ductal system. The ovarian tissue is incorporated from the left gonad within the dorsal pancreas during embryogenesis. Consequently, congenital dorsal agenesis of the pancreas (DAP) cannot be ...
Nam Yoon Jeong YJ Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu 705-703, - - 2014
Primary retroperitoneal mucinous cystadenoma is an extremely uncommon tumor, even though mucinous cystadenoma often develops in the ovary and less frequently in the pancreas. A 21-year-old female was admitted to our hospital due to severe abdominal pain. A well-demarcated, oval shaped cystic tumor at the retropancreatic area with displacement of ...
Chen Fen F Hepatobiliary and Pancreatic Intervention Center, First Affiliated Hospital, College of Medicine, Zhejiang University, 310003 Hangzhou, China. - - 2014
Objectives- The purpose of this study was to determine whether contrast-enhanced sonography can improve the ability to differentiate branch duct intraductal mucinous neoplasms from serous cystadenomas of the pancreas compared to conventional (unenhanced) sonography alone. Methods- Between March 2008 and May 2012, there were 20 patients with branch duct intraductal ...
Butt Muhammad Qasim MQ Department of Surgery, Combined Military Hospital (CMH), - - 2014
Mucocele of appendix is a rare disorder characterised by obstructive dilatation of the appendicular lumen by mucinous secretions. More commonly it is caused by mucinous cystadenoma and rarely by mucinous cystadenocarcinoma. Patients are often asymptomatic and may sometimes present with acute appendicitis. It is known to be associated with pseudomyxoma ...
Nelson John - - 2014
Mesenteric cysts are rare intra-abdominal cysts that are generally regarded as benign, and the incidence of malignancy is often cited to be 3%. The typical recommendation for treatment is complete excision to minimize recurrence. Excision can be performed laparoscopically, but this can lead to intra-abdominal dissemination of the cyst contents. ...
Fallahzadeh Mohammad Kazem MK John C. McDonald Transplant Center, Willis-Knighton Health System in - - 2014
Mucinous cystic neoplasms (MCNs) are among the most common primary cystic neoplasms of pancreas. These lesions usually occur in body and tail of the pancreas and are characterized by the presence of ovarian type stroma in the pathological evaluation. Mucinous cystic neoplasms have significant malignant potential; therefore, their diagnosis and ...
Ozgün Gonca G Department of Pathology, Uludağ University, Faculty of Medicine, BURSA, - - 2014
Heterotopic gastric mucosa in the gallbladder is an unusual entity and is usually clinically silent. We report a 75-year-old female patient who presented with intermittent upper abdomial pain radiating to the back. Abdominal imaging studies showed a sessile polypoid lesion and a gallstone in the gallbladder. Gallbladder carcinoma was suspected ...
Mitchell Andrew - - 2014
: We report an example of dysplastic intestinal-type metaplasia involving endometriosis of the appendix in a 45 year old woman. One other example of this phenomenon has been reported. As it occurs within the muscular wall of the appendix, confusion with low grade appendicial mucinous neoplasm (LAMN) may occur. Evidence ...
Goh Brian K P BK Department of Hepatopancreatobiliary and Transplantation Surgery, Singapore General Hospital, Outram Road, Singapore, Singapore, - - 2014
The Sendai Consensus Guidelines (SCG) were formulated in 2006 and updated in Fukuoka in 2012 (FCG) to guide management of cystic mucinous neoplasms of the pancreas. This study aims to evaluate the clinical utility of the SCG and FCG in the initial triage of all suspected pancreatic cystic neoplasms. Overall, ...
Morita Katsuhiko K Department of Surgery, Iwakuni Minami Hospital, Iwakuni, Yamaguchi, - - 2014
We describe rare primary pulmonary mucinous (colloid) adenocarcinoma in an 80-year-old man. Chest computed tomography revealed a lobulated, well-defined nodule with a diameter of 3.2 cm in the right middle lobe. Transbronchial biopsy via endobronchial ultrasound with a guide sheath did not uncover malignancy. Right middle lobectomy proceeded because the ...
Hanson Joshua Anspach JA From the Departments of Pathology (Drs Hanson and Mitchell) and Surgical Oncology (Dr Salem), Yale University School of Medicine, New Haven, Connecticut. Dr Hanson is now with the Department of Pathology at the University of New Mexico, Albuquerque, New - - 2014
Squamoid cyst of pancreatic ducts (SCPD) is a benign pancreatic cyst often misdiagnosed preoperatively as a mucinous cyst. The histopathologic features are well described but the cytology and quantitative fluid chemistry profiles from fine-needle aspiration have not been reported. This case series discusses the cytology and cyst fluid chemistry profiles ...
Carr Norman John NJ Peritoneal Malignancy Centre, Basingstoke and North Hampshire Hospital, Basingstoke, Southampton RG24 9NA, UK. Electronic address: - - 2014
Each year, about two per million individuals will be diagnosed with pseudomyxoma peritonei, a disease characterised by the intra-abdominal growth of neoplastic mucin-secreting cells on peritoneal surfaces. The distribution of the disease within the abdomen is not random but depends on physiological principles. Most cases derive from neoplasms of the ...
Fuks D D Department of Hepatobiliary Surgery, Hôpital Beaujon, Assistance Publique - Hôpitaux de Paris, Pôle des Maladies de l'Appareil Digestif, Université Paris 7, Clichy, - - 2014
Imaging occasionally fails to differentiate hepatic simple cysts from malignant or premalignant mucinous cystic lesions such as biliary cystadenomas. Hepatic simple cysts can be treated conservatively, whereas malignant or premalignant cysts require complete resection. This study assessed the ability of intracystic tumour marker concentrations to differentiate these disease entities. Intracystic ...
Sato Yasunori Y Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8640, - - 2014
A tumorigenic role of peribiliary glands (PBGs) has been suggested recently. This study was performed to clarify the histological characteristics of PBGs showing cystic and micropapillary epithelial changes. From histological sections of a total of 938 autopsy livers, cases with cystic and micropapillary changes of the epithelial cells of intrahepatic ...
Zen Yoh Y Histopathology Section, Institute of Liver Studies, King's College Hospital, Denmark Hill, London, - - 2014
To improve the characterization of intraductal papillary neoplasm of the bile duct (IPNB) and mucinous cystic neoplasm of the liver (MCN-L). A retrospective review of pathology archives (1999-2011) in our three institutions identified cases of IPNB (n=138) and MCN-L (n=54). The relative frequency of IPNB to MCN-L was 5.7:1 at ...
Assifi M Mura MM Department of Surgery, Thomas Jefferson University, 1025 Walnut Street, Suite 605, Philadelphia, PA, 19107, - - 2014
With the increased use of cross-sectional radiologic imaging in recent years, cystic lesions of the pancreas are being diagnosed with greater frequency. While pseuodocysts have historically accounted for the majority of benign pancreatic cysts, there are a number of rare, benign cystic lesions of the pancreas that can mimic neoplastic ...
Gaetke-Udager Kara K Department of Radiology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI, 48109, USA, - - 2014
While acute appendicitis is a common and important clinical problem, a variety of other disease processes can affect the appendix. Simple and perforated appendicitis, tip appendicitis, and stump appendicitis share a common clinical presentation including anorexia, right lower quadrant pain, and fever. By imaging, most cases of acute appendicitis exhibit ...
Barua Anupama A Department of Thoracic Surgery, St James's University Hospital NHS Trust, Leeds, - - 2014
A 42-year old woman presented with rheumatoid arthritis, dyspnoea and a congenital foregut cyst referred by a rheumatologist for thoracic surgery. The cyst was removed by video-assisted thoracoscopic surgery. The patient developed acute haemoptysis in the immediate postoperative period, which necessitated pulmonary resection due to infracted right lower lobe. This ...
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