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Fong Chun Yew CY Cancer Epigenetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, - - 2014
A wealth of genomic and epigenomic data has identified abnormal regulation of epigenetic processes as a prominent theme in hematologic malignancies. Recurrent somatic alterations in myeloid malignancies of key proteins involved in DNA methylation, post-translational histone modification and chromatin remodeling have highlighted the importance of epigenetic regulation of gene expression ...
Fortes Francisco J FJ Department of Analytical Chemistry, Faculty of Sciences, University of Malaga, Campus Teatinos s/n, Malaga, - - 2014
The diagnosis of drowning can be extremely difficult, especially when the typical morphological signs of drowning are not present, or when the body is in an advanced stage of putrefaction. The main aim of this work is to demonstrate the applicability of laser-induced breakdown spectroscopy (LIBS) to the diagnosis of ...
Goyal Lajya - - 2014
Mixed germ cell tumours of the ovary are malignant neoplasms of the ovary comprising of two or more types of germ cell components. Most of the malignant mixed germ cell tumours consists of dysgerminoma accompanied by endodermal sinus tumours, immature teratoma or choriocarcinoma. There are only few case reports of ...
Iida Tomoya T Department of Gastroenterology, Muroran City General - - 2014
An 87-year-old woman was diagnosed with primary diffuse large B-cell lymphoma of the pancreas by endoscopic ultrasonography-guided fine needle aspiration. Complete remission was achieved after treatment with six courses of R-CHOP chemotherapy. However, two and a half years later, she was readmitted because of weakness during walking. At this time, ...
Sullivan Harold C HC Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, - - 2014
Erythroblast transformation specific related gene (ERG), a proto-oncogene member of the erythroblast transformation specific transcription factor family, is a sensitive marker of endothelial differentiation and is expressed in vascular tumours, including angiosarcomas (AS). Immunohistochemistry is necessary for the diagnosis of AS in fine needle aspirates where low cellularity and lack ...
Thorbert-Mros S S Department of Periodontology, Institute of Odontology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, - - 2014
Insufficient information on the cellular composition of long-standing gingivitis lesions without signs of attachment loss makes an understanding of differences in cellular composition between "destructive" and "nondestructive" periodontal lesions difficult. The aim of the current study was to analyze differences in cell characteristics between lesions representing long-standing gingivitis and severe ...
Wood Andrew A Department of Pathology, Western General Hospital and The University of Edinburgh, Edinburgh, - - 2014
Unusual cytoplasmic alterations have recently been reported in poorly differentiated cutaneous angiosarcoma, making an accurate diagnosis challenging. As these tumours remain poorly documented, we aim to study their clinicopathological characteristics more comprehensively. Six cutaneous angiosarcomas with unusual cytoplasmic alteration were identified from referral files. All tumours arose as nodules or ...
Powers Kathleen A KA Medical Student, The University of Arizona College of Medicine, Tucson, AZ, - - 2014
A low-grade sinonasal sarcoma with neural and myogenic features has recently been defined and characterized. We present a case of this morphologic entity and discuss the differential diagnostic considerations, immunophenotypic character, electron microscopy (EM) findings and positron emission tomography (PET) appearance. We propose an alternative hypothesis of its origin on ...
Shao Hanshuang H a Department of - - 2014
Abstract Tenascin-C (TNC), a multifunctional matricellular glycoprotein, is highly expressed in the majority of melanoma cell lines and has been implicated in the progression of melanoma. A growing body of evidence has implicated the role of TNC in the process of invasion and metastasis for melanoma. However, the mechanism and ...
Sosio Corrado C IRCCS Istituto Ortopedico Galeazzi, Milan, Italy ; - - 2014
A novel three-dimensional bi-component substitute made of collagen type I and hydroxyapatite (HA) was tested for the repair of osteochondral lesions in a swine model. This scaffold was assembled by a newly developed method that guarantees the strict integration between the organic and the inorganic parts, mimicking the biological tissue ...
Kocovski Linda L Department of Pathology and Molecular Medicine, McMaster University, St Joseph's Hospital, Hamilton, - - 2014
: Malignant melanoma is commonly known as the great mimicker and can present in various clinical manifestations and with diverse morphological variants. One of the rare histological variants is the signet-ring cell type. The signet-ring morphology has been reported in numerous other neoplasms including adenocarcinoma, lymphoma, liposarcoma, squamous cell carcinoma, ...
Ferrari B B Department of Dermatology, University of Modena and Reggio Emilia, Modena, - - 2014
Early detection of melanoma is the main objective to ensure a high survival rate. In some cases melanoma diagnosis still remain difficult and this leads to unnecessary excisions. The aim of this study was to detect the most relevant Reflectance confocal microscopy (RCM) features for the detection of dermoscopic difficult ...
Inoue Tomoyuki T Department of Ophthalmology, Ehime University School of Medicine, Ehime, - - 2014
Landolt ring-shaped epithelial keratopathy is a newly identified disease with vesicular changes of unknown origin in the epithelial cells. Eleven Japanese patients with specific epithelial lesions that resembled a Landolt ring in the corneal epithelium were assessed. The main symptoms of Landolt ring-shaped epithelial keratopathy are foreign-body sensation and photophobia. ...
Das Dilip Kumar DK Department of Pathology, Faculty of Medicine, Kuwait University, - - 2014
Small round cell lesions in the neck of a pediatric patient may involve a lymph node or present as an extra-nodal solid tumor. Various proliferative lymph node lesions include non-specific reactive hyperplasia, infectious mononucleosis, Castleman's disease, Rosai-Dorfman disease, Langerhans cell histiocytosis and malignant lymphoma. Besides lymphomas, the other pediatric small ...
Donati Pietro P Dermatopathological Laboratory "San Gallicano Institute of Rome", Via Elio Chianesi, 53, 00158 Rome, - - 2014
Cellular combinations in the same neoplasm can have intriguing physiopathological implications, which may be useful to better understand the biology of the diseases. Urticaria pigmentosa in association with eruptive melanocytic nevi was observed in a female patient. Maculopapular lesions extended at the base of different melanocytic nevi and the histopathological ...
Mori Daisuke D Department of Pathology, Saga-Ken Medical Centre Koseikan, Kase 400, Saga 840-8571, Japan; Department of Clinical Laboratory, Saga-Ken Medical Centre Koseikan, Kase 400, Saga 840-8571, Japan. Electronic address: - - 2014
The presence of the so-called Hodgkin and Reed-Sternberg (H-RS) like cells may occur in T-cell non-Hodgkin lymphoma. Reported herein is the autopsy case of Hodgkin-like peripheral T-cell lymphoma (PTCL) in a 77-year-old male with gradual submandibular lymph node enlargement. The first biopsy showed Hodgkin-like PTCL, initially misdiagnosed as classical Hodgkin ...
Daley Tom T Professor, Division of Oral Pathology, Department of Pathology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. Electronic address: - - 2014
To investigate central lesions of the jaws dominated by foamy macrophages (foam cells), which are interpreted to be "central xanthomas of the jaws" and to differentiate this condition from reported cases of jaw nonossifying fibroma/fibrous cortical defect and benign fibrous histiocytoma of bone. The study is a literature review and ...
Adam Alexander C AC *Department of Pathology, University of Cologne, Köln †Department of Pathology, University of Münster, Albert-Schweitzer-Campus 1, Münster ‡Department of Pathology, University of Bonn, Bonn §Department of Pathology, University Witten/Herdecke, Helios Klinikum Wuppertal, Wuppertal, - - 2014
In this study, immunohistochemical staining pattern of cytochrome c oxidase subunit 1 (CCO1) was investigated in the differentiation of renal oncocytoma (RO) from eosinophilic (EoC) and classic chromophobe renal cell carcinoma (ChRCC). A feature found in ChRCC/EoC but not in RO is the predominance of a perinuclear halo when stained ...
Ritz Noa N Departments of *Dermatology, and †Hematology, Rambam Health Care Campus and The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, - - 2014
: T-cell receptor gene rearrangement studies are considered to be an adjunct to the histopathological diagnosis of mycosis fungoides (MF). Fluorophore-coupled primers in polymerase chain reactions followed by fragment analysis with a capillary electrophoresis device (GeneScan analysis) have been recently advocated and widely used. This study was performed to assess ...
Frank Renee R From the Departments of Pathology and Laboratory Medicine - - 2014
Mesothelin (MSLN) is a differentiation antigen found to be overexpressed in intraductal papillary mucinous neoplasms (IPMNs) and is a potential treatment target in pancreatic ductal adenocarcinoma. From institutional archives, 114 cases of resected pancreatic mucinous cysts were identified, including IPMN and mucinous cystic neoplasm (MCN). Immunohistochemical analysis of MSLN was ...
Aditi Murari - - 2014
Peripheral giant cell granuloma (PGCG) is a benign inflammatory hyperplastic lesion of unknown etiology that occurs in the gingiva or alveolar ridge. It normally manifests as a soft tissue nodule, purplish-red in color, consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. ...
Nadaf Afreen A Department of Oral Pathology, Government Dental College and Hospital, Srinagar, Jammu and Kashmir, - - 2014
Oral leukoplakia represents the most common potentially malignant oral disorder, representing 85% of such lesions. The worldwide prevalence of leukoplakia is 1.5- 4.3%. Leukoplakia is often associated with carcinogenic exposures, such as from use of tobacco, alcohol or betel nut. The level of risk for malignant transformation of leukoplakia is ...
Stoffels Josephine M J JM Department of Cell Biology, University of Groningen, University Medical Center Groningen, The - - 2014
Central nervous system remyelination by oligodendrocyte progenitor cells (OPCs) ultimately fails in the majority of multiple sclerosis (MS) lesions. Remyelination benefits from transient expression of factors that promote migration and proliferation of OPCs, which may include fibronectin (Fn). Fn is present in demyelinated lesions in two major forms; plasma Fn ...
Qian Yue Y University of Georgia, Department of Cellular Biology, Athens, Georgia, - - 2014
The development of stem cell daughters into the differentiated state normally requires a cascade of proliferation and differentiation steps that are typically regulated by external signals. The germline cells of most animals, in specific, are associated with somatic support cells and depend on them for normal development. In the male ...
Purysko Andrei S AS From the Abdominal Imaging Section, Imaging Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA, - - 2014
To assess the value of secretin during magnetic resonance cholangiopancreatography (MRCP) in demonstrating communication between cystic lesions and the pancreatic duct to help determine the diagnosis of side-branch intraductal papillary mucinous neoplasm (SB-IPMN). This is an IRB-approved, HIPAA-compliant retrospective study of 29 SB-IPMN patients and 13 non-IPMN subjects (control) who ...
Paini Marina M Marina Paini, Domenico Tamburrino, Department of Surgery, University of Verona, 37134 Verona (VR), - - 2014
Since the first description of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas in the eighties, their identification has dramatically increased in the last decades, hand to hand with the improvements in diagnostic imaging and sampling techniques for the study of pancreatic diseases. However, the heterogeneity of IPMNs and their ...
Yang Jing-Pu JP Department of Otolaryngology-Head and Neck Surgery, The Second Hospital, Jilin University, 218 Ziqiang St., Changchun 130041, China. - - 2014
B-cell lymphoma of the paranasal sinuses is rare. We present the case of a 42-year-old woman who presented with proptosis, diplopia, and vision disturbances in the right eye. She was diagnosed with diffuse large B-cell lymphoma of the ethmoid sinus. We describe the general clinical presentation, diagnosis, and differential diagnosis ...
Okamoto Natsuko N Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, - - 2014
Determination of the niche for early-stage cancer remains a challenging issue. Melanoma is an aggressive cancer of the melanocyte lineage. Early melanoma cells are often found in the epidermis around sweat ducts of human volar skin and the skin pigmentation pattern is an early diagnostic sign of acral melanoma. However, the ...
Kim Moon-Young MY Department of Pathology, Seoul National University Hospital, Seoul, South - - 2014
Congenital pulmonary airway malformation (CPAM) is a rare developmental anomaly of the lung. Here, we report a case of mucinous adenocarcinoma arising in CPAM. A 23-month-old boy underwent a thoracoscopic lobectomy of the left upper lobe of the lung based on a presumptive diagnosis of asymptomatic CPAM, found in antenatal ...
Riveiro-Falkenbach Erica E Departments of *Pathology, and †Dermatology, Hospital Universitario 12 de Octubre, Medical School, Universidad Complutense, Instituto de Investigación I+12, Madrid, - - 2014
: Mycosis fungoides (MF) is the most common type of primary cutaneous T-cell lymphoma. This entity may present with a wide spectrum of clinicopathological manifestations and mimic different dermatoses. Among its histopathological variants, spongiosis is an infrequent finding, and spongiotic microvesiculation is particularly rare. Mucinous deposition is a common event ...
Law Joanna K JK Joanna K Law, Christopher L Wolfgang, Matthew J Weiss, Anne Marie Lennon, Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD 21287, United - - 2014
Branch duct intraductal papillary mucinous neoplasms (BD-IPMN) are pre-malignant pancreatic cystic lesions which carry a small risk of malignant transformation within the cyst. Guidelines exist with respect to surveillance of the cysts using computed tomography, magnetic resonance imaging, and/or endoscopic ultrasound (EUS). There are reports that patients with IPMNs are ...
Chebib Ivan I James Homer Wright Pathology Laboratories, Massachusetts General Hospital and Harvard Medical School, Boston, - - 2014
Pancreatic cyst size >3 cm is a worrisome rather than high-risk feature for malignancy based on the 2012 International Guidelines for the management of mucinous cysts. The value of cytology in preoperative evaluation and surgical triage is unclear. All pancreatic cysts >3 cm resected over a 7-year period were evaluated ...
Boyle David P DP Dept of Pathology, Belfast Health and Social Care Trust, Belfast, Northern - - 2014
Stratified mucin producing intraepithelial lesion (SMILE) is an uncommon premalignant cervical lesion with morphological overlap between cervical intraepithelial neoplasia (CIN) and adenocarcinoma in situ (AIS)/ cervical glandular intraepithelial neoplasia. Given the limited literature on SMILE, we aimed to document its frequency and assess the associated pathology in a large series ...
Smith L A LA Gastroenterology, West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom - - - 2014
As the use of cross---sectional imaging increases so does the incidence of asymptomatic pancreatic cysts. Pancreatic neoplastic cysts can be broadly grouped into mucinous lesions and solid pseudopapillary neoplasms, which have malignant potential and serous lesions, which have negligible malignant potential. Non---neoplastic pancreatic cysts such as pseudocysts are not associated ...
Lee Linda S LS Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, - - 2014
Diagnosis of pancreatic cysts remains challenging due to limitations of currently available radiologic and endoscopic tools. The diagnostic approach should focus on identifying mucinous and malignant cysts. Mucinous cysts require further differentiation to allow appropriate management. Although the overall rate of malignant pancreatic cysts is low, it remains higher than ...
Ji Xiao-Qing XQ Department of respiratory medicine, Shandong provincial qianfoshan hospital, Jinan 250014, Shandong Province, - - 2014
Sarcoidosis is a multisystemic disorder of unknown cause that is characterized pathologically by noncaseating granulomas and predominantly affects the lung and the lymphatic system, especially intrathoracic.Diagnosis is based on the association of a compatible clinical and radiological presentation, the presence of characteristic histopathological lesions and the exclusion of other potential ...
Chen Wun-Lin WL Division of Thoracic Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, - - 2014
Cysts and cavities are common radiologic abnormalities. Pulmonary metastasis comprises a rare entity of thoracic cystic diseases. We reported a case of giant cyst at the left anterior mediastinum that was pathologically confirmed as a lung metastasis from previously resected gastric cancer. The cyst was completely removed with wedge resection ...
Surridge Clare A CA Department of Radiology, Greys Hospital, University of KwaZulu Natal, Pietermaritzburg, South - - 2014
Gastric duplication cysts are an uncommon congenital anomaly and rectal bleeding is a rare presentation of a complicated gastric duplication cyst. This case report describes the radiological findings in a child with a complicated gastric duplication cyst.
Akar H H HH Erciyes University School of Medicine, Pediatric Asthma and Allergy Unit, Kayseri, Turkey. E-mail: - - 2014
Prurigo is a condition of nodular cutaneous lesions that itch intensely. Prurigo lesions are divided into acute, subacute and chronic forms that itch intensely. Subacute prurigo (SP) clinically presents as excoriated papules mostly in a symmetrical distribution on the extensor surfaces of the extremities, neck, lower trunk, and buttocks. It ...
Popadić Mirjana M Clinic of Dermatovenereology, Clinical Centre of Serbia, Belgrade, - - 2014
Early detection of basal cell carcinoma (BCC) is of crucial importance, as serious morbidity may result from undiagnosed tumor. To evaluate diagnostic significance (specificity, sensitivity, positive and negative predictive value) of dermoscopic features in BCCs. A prospective observational study was conducted using contact polarized dermoscopy to evaluate the presence of ...
Rehulková Eva E Department of Botany and Zoology, Faculty of Science, Masaryk University, Kotlářská 2, 611 37, Brno, Czech Republic, - - 2014
Two new species of Annulotrema Paperna & Thurston, 1969 were collected from the gills of the African tiger fish, Hydrocynus brevis, from the Gambia River basin in the Niokolo-Koba National Park, Senegal. Annulotrema besalis n. sp. is characterized by having a male copulatory organ (MCO) composed of an arcuate copulatory ...
Oh Hyoung-Chul HC Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, USA, - - 2014
Cyst fluid amylase is a potential marker for pseudocysts and intraductal papillary mucinous neoplasms (IPMN). This study aimed to evaluate the diagnostic role of cyst fluid amylase and to determine the optimal cutoff values of cyst fluid amylase and carcinoembryonic antigen (CEA) for the differential diagnosis of pancreatic cysts. Based ...
Singhi Aatur D AD Pathology, University of Pittsburgh - - 2014
Purpose: Management guidelines for pancreatic IPMNs and MCNs are based on the assumption that mucinous cysts can be accurately distinguished from other pancreatic cystic lesions. Previous studies using surgical material have identified recurrent mutations in GNAS and KRAS in pancreatic mucinous neoplasms. Yet, the diagnostic utility of testing for both ...
Popadić Mirjana M Clinic of Dermatovenereology, Clinical Centre of Serbia, Belgrade, - - 2014
Early detection of basal cell carcinoma (BCC) is of crucial importance, as serious morbidity may result from undiagnosed tumor. To evaluate diagnostic significance (specificity, sensitivity, positive and negative predictive value) of dermoscopic features in BCCs. A prospective observational study was conducted using contact polarized dermoscopy to evaluate the presence of ...
Nucci Marisa R MR Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, - - 2014
Pseudoneoplastic glandular lesions of the cervix continue to be diagnostically challenging for the surgical pathologist. This review covers a select number of these lesions that may be misinterpreted as premalignant or malignant, with an emphasis on those about which Dr Scully has advanced our knowledge. The topics covered include microglandular ...
Kämmerer P W PW Department of Oral-, Maxillofacial- and Plastic Surgery, University Medical Centre of Rostock, Rostock, Germany, - - 2014
The aim of the study was an evaluation of an acetic acid wash and chemiluminescent light system in combination with toluidine blue in order to detect visual identified, potentially malignant lesions. Forty-four patients with 50 oral lesions of primary uncertain visible dignity were included. Next to a clinical examination, a ...
Gu Wei Xiang WX Yong Loo Lin School of Medicine, National University of Singapore, - - 2014
Introduction: Ultrasound-guided fine-needle aspiration cytology (US-FNAC) of thyroid nodules is an important diagnostic procedure. In most hospitals, patients are referred to radiologists for US-FNAC, but this often results in a long waiting time before results are available. Surgeon-performed US-FNAC (SP-US-FNAC) during the initial patient consultation attempts to reduce the waiting ...
Fernández-Esparrach G G Endoscopy Unit. Gastroenterology Department. ICMDM. Hospital Clínic. IDIBAPS. CIBEREHD. Universitat de Barcelona. Barcelona. - - - 2014
Incidental uniloculated cysts are diagnosed more frequently due to the increase in availability of highquality abdominal imaging. The prevalence of incidental pancreatic cysts detected on abdominal imaging is 2.6% and is even higher in old patients. Pancreatic cysts are also found in up to 25% of autopsies, 3% of which ...
Suzuki Shigeki - - 2014
Pulmonary glandular papillomas are rare neoplasms, and their very slow or absent growth over time generally facilitates establishing the diagnosis. In an 84-year-old woman who underwent surgery for sigmoid colon cancer, a growing solitary pulmonary nodule was identified on postoperative follow-up computed tomography. A computer tomography-guided needle biopsy was performed ...
Yergiyev Oleksandr O Department of Pathology and Laboratory Medicine, Allegheny General Hospital, Pittsburgh, Pa., - - 2014
Background: Acinar cell cystadenoma (ACC) is a recently recognized cystic lesion of the pancreas that demonstrates acinar differentiation and is currently believed to behave in a benign fashion. ACC enters the differential diagnosis of pancreatic cystic lesions alongside better recognized entities such as mucinous cystic and intraductal papillary mucinous neoplasms. ...
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