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Miranda Ana Mo AM Ana MO Miranda, Thiago M Ferrari, Juliana T Werneck, Arley Silva Junior, Karin SG Cunha, Eliane P Dias, Department of Pathology, Federal Fluminense University, Niteroi, Rio de Janeiro 24220-008, - - 2014
Actinic prurigo is a photodermatosis that can affect the skin, conjunctiva and lips. It is caused by an abnormal reaction to sunlight and is more common in high-altitude living people, mainly in indigenous descendants. The diagnosis of actinic prurigo can be challenging, mainly when lip lesions are the only manifestation, ...
Woods T R TR Division of Oral and Maxillofacial Pathology, Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, PO Box 100414, JHMHC, Gainesville, FL, 32610-0414, - - 2014
The desmoplastic fibroma (DF) is a rare, fibroblastic lesion of bone that histologically resembles the desmoid tumor of soft tissue. Although classified as benign, it frequently demonstrates aggressive behavior, often causing tooth mobility, extensive bone destruction, and has a moderate to high recurrence rate. We present three cases of DF ...
Garg Garima G From the Departments of Pathology and Laboratory Medicine, Pushpanjali Crosslay Hospital, Ghaziabad, Uttar Pradesh, Delhi National Capital Region, - - 2014
Uterine angioleiomyoma is an extremely rare and unique variant of leiomyoma. It usually occurs in middle-aged women, who commonly present with menorrhagia, abdominal pain, or abdominal mass. The lesions are either single or multiple and manifest as submucosal, intramural, or subserosal whorled nodules. Microscopy of the individual nodule shows interlacing ...
Werdich Xiang Q XQ David G. Cogan Laboratory of Ophthalmic Pathology; Massachusetts Eye and Ear Infirmary; Harvard Medical School, Boston, - - 2014
To correlate the clinical, radiographic, histopathologic and immunohistochemical features of five primary peri-orbital intraosseous cavernous vascular malformations. Retrospective interventional case series. Clinical and operative records and radiographic images were reviewed. Histopathologic slides were evaluated with hematoxylin and eosin, trichrome and elastic stains. Immunohistochemical studies were performed with a spectrum of ...
Wong Jackson Y JY Department of Pediatrics, University of Alberta, Edmonton, Alberta, - - 2014
Oral voriconazole is commonly used for treatment and prophylaxis of invasive fungal disease post-LTx. Development of cutaneous SCC has been described in adult LTx recipients, although it is extremely rare in children. We describe two Caucasian children who developed cutaneous SCC beyond three yr post-LTx. Both developed severe photosensitivity, actinic keratosis ...
Casadei Gian Piero GP AUSL Bologna Maggiore Hospital, Bologna, Italy - - 2014
Foci of ectopic thyroid tissue are uncommon. Most sites of thyroid ectopia are confined to the neck region. The presence of ectopic thyroid tissue outside the migration pathway of the primitive thyroid in other locations is exceptional. Given that any disease of the thyroid gland may also affect ectopic thyroid ...
Todaro P P Department of Human Pathology 'Gaetano Barresi', University of Messina, Messina, I-98125 - - 2014
Endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) has proven to be of significant value as a diagnostic method for the evaluation of esophageal mesenchymal tumors, such as true leiomyomas. Utilizing the cell block procedure, the present study reports the diagnostic approach of EUS-FNAC in two patients affected by this lesion, describing ...
Nascimento Mauricio M MM Department of Dermatology, Federal University of São Paulo, São Paulo, Brazil; Cutaneous Oncology Department, A. C. Camargo Cancer Center, São Paulo, Brazil. Electronic address: - - 2014
Pigmented actinic keratosis (PAK) is a frequent simulator of lentigo maligna (LM) on the face upon clinical and dermoscopic examination, leading to misdiagnosis and unnecessary excisions. LM and PAK share dermoscopic features, making it difficult to have a confident diagnosis of PAK only with current dermoscopic knowledge. We sought to ...
Di Carlo Aldo A San Gallicano Dermatological Institute for Research and Care, Rome, - - 2014
Various noninvasive techniques (dermoscopy, confocal microscopy, etc.) have been introduced to help the clinical diagnosis in nonmelanoma skin cancer. Among them, the high definition video thermographic technique (VTG) has recently been proposed. The aim of this study is to define the VTG patterns, respectively of actinic keratosis (AK) and basal ...
Baldi Carlo C Department of Medicine and Surgery, University of Salerno, Salerno, - - 2014
Background: A primary lymph node leiomyoma diagnosed by fine needle aspiration cytology (FNAC) is reported. Case: A 22-year-old male complained of right groin swelling; ultrasound examination (US) showed a lymph node containing a 20-mm hypoechoic nodule. The residual lymph node was oval, with a well-characterized cortex and hilum. US-FNAC of ...
Lee Ji Hyun - - 2014
Actinic keratosis (AK) is a common precursor of sun-related squamous cell carcinoma. AK is difficult to be differentiated from other malignancies with the naked eyes. Dermoscopic features of AK were previously described in some studies, but not extensively investigated. We investigated the dermoscopic features of AK in Asians and assessed ...
Moscarella E E Dermatology and Skin Cancer Unit, Arcispedale s.maria Nuova, IRCCS, Reggio Emilia, - - 2014
Actinic keratoses (AKs) are very common lesions on sun damaged skin and, when pigmented, represent a challenge in the differential diagnosis with early melanoma. Non-invasive diagnostic methods, such as dermoscopy and reflectance confocal microscopy (RCM) have been shown to improve the diagnostic accuracy of melanoma and non-melanoma skin cancer, however, ...
Lim Geoffrey F S GF Department of Dermatology, Drexel University College of Medicine, The Arnold T. Berman, M.D. Building, 219 North Broad Street, Philadelphia, PA 19107, USA. Electronic address: - - 2014
The purpose of this article is to review the common neoplasms, infections, and inflammatory dermatoses that may present around or near the mouth. Dental professionals are well positioned to evaluate perioral skin conditions, further contributing to patients' general health. This article includes a review of seborrheic keratosis, warts, actinic keratoses, ...
Tschandl P P Department of Dermatology, Division of General Dermatology, Medical University of Vienna, Vienna, - - 2014
The diagnosis of flat pigmented lesions on the face is challenging because of the morphologic overlap of biologically different lesions and the unknown significance of dermatoscopic patterns. To better characterize dermatoscopic patterns of various types of flat pigmented facial lesions and to analyse their significance by calculating their relative risks ...
Alarcón I I Unidad de Melanoma, Servicio de Dermatología, Hospital Clinic de Barcelona, Barcelona, Spain. Electronic address: - - 2014
Facial lentigo maligna melanoma can be a diagnostic challenge in daily clinical practice as it has similar clinical and morphological features to other lesions such as solar lentigines and pigmented actinic keratoses. Confocal microscopy is a noninvasive technique that provides real-time images of the epidermis and superficial dermis with cellular-level ...
Sant'ana Fabiano J F de FJ Laboratory of Veterinary Pathology, University of Brasília, Brasília, Distrito Federal, Brazil (de - - 2014
The current report describes 3 rare cases of mammary diffuse fibroadenomatoid hyperplasia in water buffalo (Bubalus bubalis). All of the animals were between 10 and 12 months of age. Grossly, the lesions consisted of severe diffuse swelling with homogeneous large masses in the udder. Surgical removal of the masses was ...
Stockfleth Eggert E Department of Dermatology, Charité - University Medical Centre Berlin, Charité Platz 1, Berlin, D-10117, - - 2014
Background Current parameters for assessing the efficacy of actinic keratosis (AK) treatments compare clinical lesions at the start and end of a study. However, the sun-exposed field also contains subclinical lesions which may become detectable during treatment. Lmax, the maximum lesion count during treatment, is a new concept to better ...
Ljubojevic Suzana S Department of Dermatology and Venereology, University Hospital Center Zagreb, School of Medicine University of Zagreb, Zagreb, Croatia. Electronic address: - - 2014
Nearly 200 distinct human papilloma viruses (HPVs) have now been recognized, and each is associated with a specific set of clinical lesions. They are associated with a spectrum of diseases, from benign verrucae vulgares and condylomata acuminata to the malignancies of the cervix, vulva, anus, and penis. Disease associated with ...
Gilani S M - - 2014
Inflammatory myofibroblastic tumour (IMT) is a rare, distinctive mesenchymal neoplasm. Grossly, it appears as a circumscribed mass with a rubbery to firm cut surface. Microscopically, it is characterized by a spindle cell proliferation within a myxoid stroma with admixed plasma cells, lymphocytes and eosinophils. Immunohistochemical staining is usually positive for ...
Eyselbergs M - - 2014
Noonan syndrome (NS) is an etiologically heterogeneous disorder caused by mutations in the RAS-MAPK signaling pathway. Noonan-Like/Multiple Giant Cell Lesion (NL/MGCL) syndrome is initially described as the occurrence of multiple gnathic giant cell lesions in patients with phenotypic features of NS. Nowadays, NS/MGCL syndrome is considered a variant of the ...
Kourilovitch Maria M State University, Cuenca, Ecuador; Center of Translational Medicine, State University, UNERA (Unit of Rheumatic Disease and Autoimmunity), Medical Corporation Mount Sinai, Cuenca, - - 2014
Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease of unclear etiology that is manifested in by a progressive and destructive polyarthritis in association with serological evidence of autoreactivity. It diagnosis is based on the classification criteria that involves four parameters: joint involvement, serology (rheumatoid factor and anti-cyclic citrullinated peptide ...
Bonkevitch F F Internal Medicine, Hospital São Lucas da PUCRS e Santa Casa de Misericórdia de Porto Alegre, Avenida Ipiranga, 6690, Porto Alegre, RS, Brazil. Electronic address: - - 2014
Cutis rhomboidalis nuchae is a skin alteration which comes from chronic sun exposure and it integrates the solar elastosis group, acquiring a coriaceous aspect, with a yellowish and grooved surface. There is the occurrence of elastic and collagen fibers degeneration found in the dermis caused by ultraviolet radiation [1]. Another ...
Zalaudek Iris - - 2014
Actinic keratoses (AKs) represent the earliest stage in the development of squamous cell carcinoma (SCC) and represent important biomarkers for individuals at risk for development of invasive SCC. Based on clinical morphology, AK can be subdivided into three different grades, which correspond to specific dermatoscopic, reflectance confocal microscopic, and histopathologic ...
Zalaudek Iris - - 2014
The clinical recognition of lentigo maligna (LM) in the mottled chronic sun-damaged skin can be challenging, because it shares many clinical features with other pigmented macules that commonly arise on sun-damaged skin. These include solar lentigo, flat seborrheic keratosis, and pigmented actinic keratosis, but almost never "nevus." The reason nevus ...
Lallas Aimilios - - 2014
The differential diagnosis of pigmented macules on the mottled chronic sun-damaged skin of the face is challenging and includes lentigo maligna (LM), pigmented actinic (solar) keratosis, solar lentigo, and lichen-planus-like keratosis. Although dermatoscopy improves the diagnostic accuracy of the unaided eye, the accurate diagnosis and management of pigmented facial macules ...
Zito Giovanni G Department of Genetics, Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut 06510, - - 2014
A fundamental goal in cancer biology is to identify the cells and signalling pathways that are keys to induce tumour regression. Here we use a spontaneously self-regressing tumour, cutaneous keratoacanthoma (KAs), to identify physiological mechanisms that drive tumour regression. By using a mouse model system that recapitulates the behaviour of ...
Guazzaroni M M Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiation Therapy, University Hospital Tor Vergata, Viale Oxford, 81-00133 Rome, - - 2014
Uterine leiomyosarcoma (ULMS) is an uncommon malignancy that accounts for one-third of uterine sarcomas and represents 1% of all uterine malignancies, with an incidence averaging 0.5-1/100,000/year. The prognosis is poor due to its intrinsic aggressiveness and its characteristic high metastatic potential with reported distant metastatic spread in lung, abdomen, soft ...
Terroso G - - 2014
Rheumatoid arthritis (RA) patients have increased risk of lymphoma which seems associated mainly with high inflammatory state and disease activity, but also with immunosuppressive agents or Epstein-Barr virus (EBV) infection. Many case reports describe lymphoproliferative lesions arising during methotrexate therapy, often EBV positive with possible regression after me - thotrexate ...
Deonizio Janyana J 0000-0003-1154-7186 Dermatology Department, Federal University of Parana, Rua General Carneiro, 181 Alto da Glória, 80060-900 Curitiba, PR, - - 2014
Background. Cryopeeling is a technique that uses cryotherapy not only on actinic keratoses lesions, but also all over the photodamaged skin. Objectives. To investigate the histological changes induced by two cryopeeling methods (liquid nitrogen (LN) and portable system (PS)). Methods. Sixteen patients (n = 16) with multiple actinic keratoses on ...
Xiao Ruo-Zhi RZ Department of Hematology, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China ; Sun Yat-Sen Institute of Hematology, Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. - - 2014
Felty's syndrome (FS) is characterized by the three conditions of rheumatoid arthritis (RA), neutropenia and splenomegaly, and occurs in few cases of longstanding erosive RA. Discriminating between rare occurrences of autoimmune diseases and malignancies is crucial. The present study describes the case of a 17-year-old female with a two-year history ...
Warner Catherine C aDepartment of Pediatrics, Hofstra Northshore-LIJ School of Medicine, New Hyde Park, NY bDepartment of Surgery (Dermatology), Geisel School of Medicine at Dartmouth, Hanover cDepartment of Dermatology, University of Connecticut, Farmington Connecticut dDermatology & Skin Health, Dover, New Hampshire, - - 2013
Congenital melanocytic nevi (CMN) and infantile hemangiomas are commonly encountered in newborns and may present diagnostic and therapeutic dilemmas for medical practitioners. Herein, we review and discuss these two important clinical entities and focus on core issues and recent advances. Melanoma risk for patients with CMN is greatest in infants ...
Bhat Amoolya A Assistant Professor, Department of Pathology, Sapthagiri Institute of Medical Sciences and Research Centre , Bangalore-90, India - - 2013
"Soft tissue giant cell tumour of low malignant potential" is considered as the soft tissue counterpart of osteoclastoma of the bone. It is a primary soft tissue tumour which is classified under the category of fibrohistiocytic tumours of intermediate malignancy.Seventy percent of the tumours involve the extremities and only about ...
Kamath Sulata Manjunath SM Professor, Department of Pathology, M S Ramaiah Medical College & Teaching Hospital , India - - 2013
Solitary Fibrous Tumour (SFT) is an unusual spindle cell tumour that usually occurs in the pleura, but has recently also been reported to be extra-pleural in origin. A renal presentation is very rare. Upto 90% of the tumours have benign characteristics. It is difficult to differentiate it from renal cell ...
Kumar A Sathish Selva AS Assistant Professor, Department of Pathology, Affiliated to ESIC-Medical College & PGIMSR , K.K.Nagar, Chennai-78, India - - 2013
Stromal tumours occurring in areas other than the GastroIntestinal Tract (GIT) are known as Extra GastroIntestinal Stromal Tumours (EGISTs). They usually arise in the mesentery, omentum or retroperitoneum, while EGISTs which occur in the abdominal wall are very rare. Both gastrointestinal stromal tumours (GISTs) and EGISTs are histologically and immunophenotypically ...
Iorio Matthew L ML Washington, D.C. From the Department of Plastic Surgery, Georgetown University Hospital; Georgetown Dermatology; and DAVinci Plastic - - 2013
After studying this article, the participant should be able to: 1. Identify common precancerous and malignant cutaneous growths of the head and neck. 2. Recommend surgical treatment, including margins, based on consensus guidelines. 3. Counsel patients as to available evidence for expected recurrence, follow-up, and morbidity. Skin lesion excision is ...
Lima Francisco Jadson - - 2013
Nodular fasciitis is a benign, idiopathic, reactive proliferation of myofibroblasts found in the subcutaneous fascia; intraoral occurrence is very rare. An 18-year-old woman was referred to the oral diagnosis service with a 1-month history of a nodular mass in the gingiva. Clinical examination disclosed a well-circumscribed, mobile, pedunculated mass in ...
Orsaria M - - 2013
This report describes an unusual case of a large solitary fibrous tumour (SFT) arising in the retroperitoneum. A 53-year-old woman presented at the Emergency Department with urinary retention and lumbar pain. The urological examination was negative, whereas a presacral retroperitoneal mass was disclosed on ultrasound. The laboratory studies, including tumour ...
Tanaka Noriko - - 2013
We treated 12, 15 and 13 Japanese actinic keratosis (AK) lesions with 5-aminolevulinic acid photodynamic therapy (PDT), 5% imiquimod cream and combination of both therapies, respectively, and compared the effects. Patients underwent the second course, when AK lesions remained after the first course. Efficacy was evaluated 1 month after each treatment. ...
Takahashi Mayu - - 2013
A 71-year-old woman with active rheumatoid arthritis (RA) was referred to our department because of multiple intracranial nodules. On admission, the RA disease activity was very high even after the treatment of methotrexate in other hospital. She underwent open biopsy to confirm a histopathological diagnosis of the intracranial lesions. Surgical ...
Kaito Takashi - - 2013
Study Design. Retrospective cohort analysisObjective. To clarify the effect of biological agents (BAs) on the development and progression of cervical lesions in patients with rheumatoid arthritis (RA) and to identify biomarkers that accurately predict disease progressionSummary of Background Data. The introduction of BAs changed the paradigm of RA treatment. However, ...
Ki Eun Young - - 2013
Benign leiomyomas of the uterus are uncommonly found in association with benign smooth muscle tumors beyond the confines of the uterus. Benign metastasizing leiomyoma (BML) is a rare disease in which the lung is described to be the most afflicted extrauterine organ. We present a brief review of the literature, ...
García-Martínez Francisco Javier - - 2013
X-linked dominant protoporphyria (XLDPP) is a genetic disorder that affects the synthesis of the heme group due to an increase in delta-aminolaevulinate synthase 2 (ALAS2) enzyme activity. Moreover, annular elastolytic giant-cell granuloma (AEGCG) is a rare reactive granulomatous dermatosis, usually associated with actinic damage. An 86-year-old man presented with edematous-erythematous ...
Ross Kate K Department of Dermatology, University of South Florida, Tampa, - - 2013
Topical photodynamic therapy (PDT) is an option for the treatment of cutaneous malignancy. To present an update and expansion on a previous review of the use of PDT in the current literature in the treatment of actinic keratoses (AK), superficial and nodular basal cell carcinoma (sBCC, nBCC), squamous cell carcinoma ...
Cozzolino Immacolata - - 2013
Fibrosarcoma (FS) accounts for about 3% of all soft tissue sarcomas. It may arise in any area of the body, but it is relative rare in the head and neck district. Fine-needle cytology (FNC) is widely used in the diagnosis of neoplastic and non-neoplastic lesions of soft tissue. This article ...
Kazlouskaya Viktoryia - - 2013
Basal cell carcinoma (BCC) has a characteristic stroma, but less is known about the dermal characteristics associated with melanoma in situ (MIS) and actinic keratosis (AK). Dermal changes were studied in 301 specimens of AK, BCC and MIS. Subsequently, blinded images of dermal changes from 90 randomly selected cases of ...
Kallini Joseph R - - 2013
Lentigo maligna is a melanocytic neoplasm, often regarded as 'melanoma in situ,' which may progress to lentigo maligna melanoma. Lentigo maligna clinically presents as a pigmented, asymmetric macule that originates on the head and neck and spreads slowly. The preferred method for diagnosing lentigo maligna is excisional biopsy. Histology shows proliferation ...
Lafçı Gökhan - - 2013
Angiosarcoma, the most common primary malignant neoplasm of the heart in adults, usually presents as pericardial effusion or right-sided heart failure. Rupture of an angiosarcoma-infiltrated cardiac chamber as a cause of hemothorax is very rare in the literature. In this report, we describe a 34-year-old male patient, who presented to ...
Chatterjee Kingshuk - - 2013
The report highlights the occurrence of basal cell carcinoma in a native Indian with oculo-cutaneous albinism, an association not frequently encountered. The clinical and histopathological features, which assisted to form the diagnosis, are outlined. A high degree of suspicion and timely recognition of the potentially aggressive neoplasm, under this unusual ...
Lorette Gérard G Department of Dermatology, CHU Tours, Université François Rabelais Tours, Tours, France, - - 2013
A 4-year-old boy presented a translucent cyst on the left lateral side of the urethral meatus. The lesion was excised. Histological examination showed features of a cystic lesion within the dermis surrounded by a thin epithelium of columnar cells with a round apical pole. Immunohistochemical staining was positive for pan-cytokeratins ...
Proietti Agnese - - 2013
Background. The distinction between follicular adenomas and well differentiated follicular and papillary carcinomas is often a demanding task and sometimes only intuitive. Aim. We report an histomorphological evaluation of follicular neoplasms (follicular adenomas FAs, follicular carcinomas FCs and follicular variant of papillary carcinomas FVPTCs), supported by a qualitative and quantitative ...
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