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Malvehy J J Melanoma Skin Unit, University Hospital Clinic of Barcelona, Barcelona, - - 2015
In actinic keratosis (AK), clinical and subclinical lesions coexist across large areas of sun-exposed skin resulting in field cancerization. The lesions are part of a disease continuum which can progress into invasive squamous cell carcinoma (SCC). Conventional biopsy sampling together with histopathological analysis of the excised tissue is still the ...
Guille Jeremy T JT Division of Otolaryngology, Head and Neck Surgery, Division of General Surgery, Department of Surgery, University of Wisconsin, Madison, Wisconsin, - - 2014
Thyroid nodules are commonly diagnosed in adults. Although rare in children, the risk for thyroid cancer is much higher in the pediatric population compared with adults. Presenting as either a solitary nodule or a multinodular goiter, thyroid nodular disease in children requires a thorough workup that includes a detailed clinical ...
Armes Jane E JE Department of Anatomical Pathology, Mater Health Services, South Brisbane, Queensland, - - 2014
Diffuse lung disease (DLD) of infancy has multiple aetiologies and the spectrum of disease is substantially different from that seen in older children and adults. In many cases, a specific diagnosis renders a dire prognosis for the infant, with profound management implications. Two recently published series of DLD of infancy, ...
Gremião Isabella D F ID Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil - - 2014
Feline sporotrichosis, which is caused by species of the Sporothrix schenckii complex, is endemic to Rio de Janeiro, Brazil. More than 4000 cases of the disease were diagnosed at Fundação Oswaldo Cruz, Brazil, between 1998 and 2012. Sporotrichosis in cats has been reported in several countries, but nowhere has an ...
Chougule Abhijit A 1Departments of Histopathology 2General Surgery, Post Graduate Institute of Medical Education and Research, (PGIMER), Chandigarh, - - 2014
IgG4 related disease (IgG4RD) is a recently recognised condition characterised by mass forming lesions associated with storiform fibrosis, obliterative phlebitis, lymphoplasmacytic infiltrate rich in IgG4 positive plasma cells and elevated serum IgG4 levels. Although rare, mammary involvement has been reported as IgG4 related sclerosing mastitis, the morphological counterpart of a ...
Ahn Christine S CS *Dermatology Resident, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC; †Pathologist, Department of Pathology, King Fahad Hospital, University of Dammam, Dammam, Saudi Arabia; and ‡Professor of Pathology and Dermatology, Director of Dermatopathology, Department of Pathology, Wake Forest School of Medicine, Winston-Salem, - - 2014
: Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma. Although it was first described in 1833, our understanding of this disease has continued to evolve. From a diagnostic perspective, the diagnosis of MF can be challenging particularly in the early stages of the disease, because of overlap ...
Blau Lance N LN Methodist DeBakey Heart & Vascular Center, Department of Cardiovascular Surgery, Houston Methodist Hospital, Houston, Texas. Electronic address: - - 2014
Treating heart masses demands a well-planned diagnostic strategy. As with any disease in medicine, the confirmation of a diagnosis leads to a tailored, more efficacious treatment. We present the case of a 72-year-old man presenting with a right atrial mass on echocardiography and diagnosis of plasmacytoma after transvenous endomyocardial biopsy.
Barua Anupama - - 2014
Castleman¿s disease is a benign lymphoproliferative disease characterised by hyperplasia of lymphoid follicles. It can affect any lymph nodes in the body. Here we describe a caucasian patient who presented with six months history of shortness of breath with CT scan confirming an 8 cm segment of consolidated lung in left ...
Santos Ana Filipa AF Neurology Department, Hospital de Braga, Braga, Portugal. Electronic address: - - 2014
Hypertrophic olivary degeneration is a rare kind of trans-synaptic degeneration that occurs after lesions of the dentatorubro-olivary pathway. The lesions, commonly unilateral, may result from hemorrhage due to vascular malformation, trauma, surgical intervention or hypertension, tumor, or ischemia. Bilateral cases are extremely rare. This condition is classically associated with development ...
Maddocks C E CE Institute of Aquaculture, Stirling University, Stirling, - - 2014
Puffy skin disease (PSD) is a disease that causes skin pathology in rainbow trout, Oncorhynchus mykiss (Walbaum). Incidence of PSD in UK fish farms and fisheries has increased sharply in the last decade, with growing concern from both industry sectors. This paper provides the first comprehensive case definition of PSD, ...
Shimizu Shigeki S Department of Laboratory Medicine and Pathology, National Hospital Organization Kinki-chuo Chest Medical Center, Osaka, Japan; Department of Molecular Pathology, Hyogo College of Medicine, Hyogo, Japan. Electronic address: - - 2014
A calcifying fibrous pseudotumor (CFPT) is a rare benign lesion that often presents in the upper and lower extremities of children and young adults. In the present report, we describe a case of a small CFPT arising from the epicardium (visceral pericardium) in a 32-year-old woman. The tumor presented as ...
Onder Evrim E Department of Pathology, Ankara Dışkapı Yıldırım Beyazıt Research and Training Hospital, ANKARA, - - 2014
Since Lhermitte-Duclos is a quite rare disorder with both neoplastic and hamartomatous features, clinical and pathological diagnosis can sometimes be challenging. For the pathologist it is of extreme importance to be aware of variable clinical and histopathological presentations of such a rare lesion particularly to differentiate it from the low-grade ...
Waterman Jack J College of Osteopathic Medicine, Nova Southeastern University, 3301 College Avenue, Fort Lauderdale, FL 33314, USA; Jupiter Kidney Center, 1701 North Military Trail, #140, Jupiter, FL 33458, USA. Electronic address: - - 2014
Renal cysts are commonly encountered in clinical practice. Although most cysts found on routine imaging studies are benign, there must be an index of suspicion to exclude a neoplastic process or the presence of a multicystic disorder. This article focuses on the more common adult cystic diseases, including simple and ...
Griff Sergej - - 2014
Due to the small amount of alveolar tissue in transbronchial biopsy (TBB) by forceps, the diagnosis of diffuse, parenchymal lung diseases (DPLD) is inherently problematic, with an overall low yield. The use of cryotechnique in bronchoscopy, including TBB by cryoprobe, has revealed new opportunities in the endoscopical diagnosis of malignant ...
Ahern Benjamin J BJ Department of Clinical Studies, School of Veterinary Medicine, New Bolton Center, University of Pennsylvania, Kennett Square, PA 19348., Randwick Equine Center, 3 Jane St, Sydney, NSW 2031, - - 2014
Objective-To evaluate equids with enostosis-like lesions (ELLs) and document the clinical and epidemiological features of this disease. Design-Retrospective case series. Animals-79 equids with a scintigraphic diagnosis of at least 1 ELL on ≥ 1 occasion. Procedures-Medical records of 4,992 equids that underwent bone scintigraphy between March 1997 and March 2009 ...
Lewis Rachel B RB From the American Institute for Radiologic Pathology, 1010 Wayne Ave, Suite 320, Silver Spring, MD 20910 (R.B.L., M.A.M.); Department of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, Bethesda, Md (R.B.L.); the Joint Pathology Center, Silver Spring, Md (A.K.M.); Department of Radiology, La Princesa University Hospital, Madrid, Spain (P.R.); Department of Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Md (M.A.M.); and Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa - - 2014
Gastrointestinal (GI) lymphoma encompasses a heterogeneous group of neoplasms that have a common lymphoid origin but variable pathologic and imaging features. Extranodal marginal zone B-cell lymphoma (ENMZL) and diffuse large B-cell lymphoma (DLBCL) are the most common. ENMZL usually occurs in the stomach, where it is associated with chronic infection ...
Hosseini Marzieh M From the *Department of Pathology Laboratory, Iranian Legal Medicine Research Center; and †Mashhad Legal Medicine Research Center, Mashhad, - - 2014
Hydatid disease of the liver is a parasitic infection primarily caused by the larvae of Echinococcus granulosus. Hydatid cysts may remain clinically silent for many years and are often an incidental finding on ultrasonography performed for unrelated reasons. Sudden death due to unrecognized hydatid cysts can occur, and rare case ...
Ingle Sachin B SB Sachin B Ingle, Department of Pathology, MIMSR Medical College, Latur, Maharashtra 4132512, - - 2014
Primary idiopathic intestinal lymphangiectasia is an unusual disease featured by the presence of dilated lymphatic channels which are located in the mucosa, submucosa or subserosa leading to protein loosing enteropathy.Most often affected were children and generally diagnosed before third year of life but may be rarely seen in adults too. ...
Canavese Gabriella G Pathology Department, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Turin, Italy. Electronic address: - - 2014
The diagnosis of inflammatory bowel disease can be challenging and requires the efforts of a multidisciplinary team. We performed a retrospective analysis with the aim of evaluating the adequacy of the prerequisites for arriving at an accurate histological diagnosis. The following parameters were considered as prerequisites for a diagnosis of ...
Beranger-Gibert Sophie S Department of Radiology, Beaujon Hospital, AP-HP, University Hospitals Paris Nord Val de Seine, 100 Boulevard du Général Leclerc, 92118, Clichy, Hauts-de-Seine, - - 2014
The liver is rarely involved in female genital diseases or pregnancy. Peripheral hepatic and perihepatic lesions are mainly due to the progression of genital malignancies, usually ovarian cancer. It should be distinguished from other malignant and non-malignant lesions. In all clinical situations, liver involvement is a sign of distant extension ...
Oliveira Alves Mônica Ghislaine MG Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, UNESP - Universidade Estadual Paulista, São José dos Campos, São Paulo, - - 2014
Oral lichen planus (LP) is an immune-mediated disease.(1) In 2005, the World Health Organization (WHO) classified it as a potentially malignant disorder,(2) but this classification is controversial.(3,4) Authors have discussed the criteria used for the diagnosis of oral LP in the cases of malignant transformation reported in the literature.(3,4) This ...
Smeets Bart B Division of Nephrology and Clinical Immunology, Department of Internal Medicine II, and the Q1 platform of the TRR57,(¶¶) Institute for Pathology, RWTH Aachen University Hospital, Aachen, - - 2014
In rodents, parietal epithelial cells (PECs) migrating onto the glomerular tuft participate in the formation of focal segmental glomerulosclerosis (FSGS) lesions. We investigated whether immunohistologic detection of PEC markers in the initial biopsies of human patients with first manifestation of idiopathic nephrotic syndrome with no immune complexes can improve the ...
Churg Andrew A Department of Pathology, Vancouver General Hospital, - - 2014
A new smoking-associated lesion has been described in the pathology literature over the last few years by various names including RBILD with fibrosis, smoking-related interstitial fibrosis, and airspace enlargement with fibrosis. The lesion consists of localized patches of paucicelluar interstitial fibrosis mixed with emphysema, and frequently forms a wedge shape ...
Colby Thomas T Mayo Clinic Arizona, - - 2014
Neither the pathologist nor the radiologist makes the diagnosis of IPF. It is a clinical diagnosis. Current recommendations are that the diagnosis of IPF follows multidisciplinary discussion (MDD) involving clinicians, radiologists and, if tissue is take, pathologists. According to the 2011 IPF guidelines, the diagnosis of IPF requires the pathologic ...
Varada Sowmya - - 2014
Benign chronic familial pemphigus (BFCP) is an autosomal dominant dermatosis characterized by flares of painful and often debilitating blistering lesions in high friction areas of the body such as the groin, axillae, lateral neck, and intergluteal cleft. Limited knowledge of its pathophysiology has made treatment of BFCP a considerable challenge ...
Imielski Bartlomiej R BR Medical College of Wisconsin, Milwaukee, - - 2014
We present a case of a 33-year-old female with a slow growing, right peribronchial vascular mass and associated symptoms of progressive cough, dyspnea on exertion, and hemoptysis. On routine diagnostic flexible bronchoscopy with needle biopsy, the lesion hemorrhaged extensively requiring emergent thoracotomy, right lower and middle bilobectomy. The histopathology of ...
Haenssle Holger A HA Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany ; Department of Dermatology, Venereology and Allergology, University Medical Center Heidelberg, Heidelberg, - - 2014
Pigmented and non-pigmented nail alterations are a frequent challenge for dermatologists. A profound knowledge of clinical and dermatoscopic features of nail disorders is crucial because a range of differential diagnoses and even potentially life-threatening diseases are possible underlying causes. Nail matrix melanocytes of unaffected individuals are in a dormant state, ...
Vetro Calogero C Calogero Vetro, Alessandra Romano, Irene Amico, Concetta Conticello, Giovanna Motta, Amalia Figuera, Annalisa Chiarenza, Cosimo Di Raimondo, Giuseppe Alberto Palumbo, Francesco Di Raimondo, Division of Hematology, AOU Policlinico-OVE, University of Catania, 95124 Catania, - - 2014
Many progresses have been done in the management of gastrointestinal (GI) lymphomas during last decades, especially after the discovery of Helicobacter pylori-dependent lymphoma development. The stepwise implementation of new endoscopic techniques, by means of echoendoscopy or double-balloon enteroscopy, enabled us to more precisely describe the endoscopic features of GI lymphomas ...
Zamel Ghada Al GA Former Resident, Department of Oral Medicine, University of Pennsylvania School of Dental Medicine, Philadelphia, - - 2014
Paraneoplastic pemphigus (PNP) is a mucocutaneous disease that occurs in association with an underlying neoplasm. Oral mucosal lesions may be the only manifestation of this condition, or they may be observed in association with cutaneous lesions. The prognosis of PNP is generally poor, and the disease is often fatal. This ...
Kishi Chikako C Department of Dermatology, Graduate School of Medicine, Gunma University, Maebashi, - - 2014
A 64-year-old Japanese woman was diagnosed as having Bowen's disease in the vulva. The histopathological findings revealed papillomatosis, koilocytosis and clumping cells with atypical nuclei. Human papillomavirus DNA was not detected on polymerase chain reaction using consensus primers. The lesion was successfully treated with topical imiquimod 5% cream after two ...
Ling Galina - - 2014
Background: Neonatal ascites is a rare entity, which is usually biliary, urinary, or chylous. Congenital hepatic fibrosis as part of the manifestations of autosomal recessive polycystic kidney disease (ARPKD) is usually a histological adjunct to the diagnosis of this mainly clinically renal entity in the neonatal period. Case-diagnosis: We describe ...
Pender D J DJ Department of Otolaryngology - Head and Neck Surgery,Columbia University Medical Center,New York,New - - 2014
Objective: To determine whether the distribution of membrane lesions associated with Ménière's disease is random, as might be expected from a pervasive process such as hydrops, or orderly, as might be expected if membrane resistance is graded. Method: A meta-analysis of temporal bone reports on 184 specimens demonstrating endolymphatic hydrops ...
Senaratne Thamarasi N TN Department of Microbiology, Faculty of Medicine, University of Peradeniya, Sri - - 2014
Dengue fever (DF) is a mosquito borne virus infection which is endemic to the tropical regions of the world. In Sri Lanka, the first sero-positive case was reported in 1960's; since then the island has experienced several outbreaks of DF/dengue haemorrhagic fever (DHF). The disease is more prevalent in some ...
Kassa Berhe Gebreseslassie - - 2014
Hydatidosis is a tapeworm infection caused by the larval stage of Echinococcus species. The organs most frequently affected are the liver and the lungs. Primary involvement of the skeleton is rare. The location of hydatid cysts in the tibia is seldom described in the medical literature, and its diagnosis is ...
Noli Chiara C Servizi Dermatologici Veterinari, Strada Bedale della Ressia 2, Peveragno, CN, I-12016, Italy. Electronic address: - - 2014
Canine leishmaniosis caused by Leishmania infantum is still a common disease in endemic areas, such as the Mediterranean countries, and has progressively expanded into non-endemic areas like Central and Northern Europe. The aim of this article is to critically review current knowledge on the diagnosis and treatment of this disease. ...
Johnston Stephen Albert - - 2014
Cancer diagnosis in both dogs and humans is complicated by the lack of a non-invasive diagnostic test. To meet this clinical need, we apply the recently developed immunosignature assay to spontaneous canine lymphoma as clinical proof-of-concept. Here we evaluate the immunosignature as a diagnostic for spontaneous canine lymphoma at both ...
Cankaya Hülya - - 2014
Oral squamous cell carcinoma (OSCC) is the most prevalent cancer of the head and neck with over 500,000 new cases every year worldwide. The stage of disease at diagnosis is associated with the 5-year survival rate. Unfortunately, approximately two-thirds of patients are diagnosed with advanced disease with local and regional ...
Wuyts Wim A WA Unit for Interstitial Lung Diseases, Dept of Pulmonary Medicine, University Hospitals Leuven, Leuven, Belgium. Operative Unit of Pathology, S. Maria Nuova Hospital, Reggio Emilia, Italy. Section of Pathology, University Hospital of Modena, Modena, Italy. Section of Diagnostic Imaging, Dept of Surgery, University of Parma, Parma, Italy. Interstitial and Rare Lung Disease Unit, Ruhrlandklinik, University Hospital, University of Duisburg-Essen, Germany. Medical University Clinic, Canton Hospital Baselland and University of Basel, Liestal, - - 2014
Idiopathic pulmonary fibrosis (IPF), the most common and lethal of the idiopathic interstitial pneumonias, is defined by a radiological and/or pathological pattern of usual interstitial pneumonia (UIP). However, UIP is not synonymous with IPF as other clinical conditions may be associated with UIP, including chronic hypersensitivity pneumonitis, collagen vascular disease, ...
Babu D D Tata Memorial Hospital, Mumbai, - - 2014
Haemangiomas are one of the most common benign tumours. Clinicians come across haemangiomas of different subtypes at different locations in the body. They are often faced with the question of whether to treat them or leave it to the natural history of the disease. We present a case of the ...
Faria Adriane Reichert AR Santa Casa de Misericórdia Hospital, Curitiba, PR, - - 2014
In an unprecedented effort in the field of vitiligo, a global consensus resulted on a suggested new classification protocol for the disease. The main histopathological finding in vitiligo is the total absence of functioning melanocytes in the lesions, while the inflammatory cells most commonly found on the edges of the ...
Numbere Numbere K - - 2014
A 50-year-old man presented to clinic with a two-year history of progressive exertional dyspnea and voice hoarseness. This history suggested upper airways obstruction, which was confirmed on computed tomography imaging that revealed extensive thickening of the proximal tracheal wall causing severe luminal narrowing. Bronchoscopic debulking was then performed and the ...
Jan Suhail Majid SM Department of Periodontics and Oral Implantology, Government Dental College and Hospital, Srinagar, Kashmir, - - 2014
Tuberculosis (TB) is a chronic specific granulomatous disease and a major cause of death in developing countries. The clinical presentation of TB lesions of the oral cavity varies widely and can manifest as ulcerations, diffuse inflammatory lesions, granulomas and fissures. Oral lesions generally appear secondary to primary TB infection elsewhere, ...
van der Tol Linda L Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam Lysosome Center 'Sphinx', Amsterdam, - - 2014
Screening for Fabry disease (FD), an X-linked lysosomal storage disorder, reveals a significant number of individuals with a genetic variant of unknown significance without classical FD manifestations; these variants in the α-galactosidase A gene often result in a high residual leukocyte α-galactosidase A and it is unclear whether these individuals ...
Kocabeyoglu Sibel S Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, - - 2014
To report the clinical and in vivo confocal microscopic (IVCM) findings of corneal deposits in a patient with tyrosinemia type II. The pretreatment and 1-month posttreatment slit-lamp examination and IVCM findings of a patient with tyrosinemia type II are described. A 12-year-old girl diagnosed with tyrosinemia type II was evaluated ...
Petrović Dragan - - 2014
Sinus histiocytosis with massive lymphadenopathy is a rare benign self-limiting disease of unknown etiology. The salivary gland involvement, indicating the extranodal character of the disease, often presents a diagnostic dilemma requiring immunohistochemical staining of surgically removed tumor to confirm the diagnosis. We report a 43-year-old man presented with an asymptomatic ...
Ladak Aleem A Breast Unit, North Manchester General Hospital, Manchester, - - 2014
Pigmented extramammary Paget's disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget's disease affecting skin that is rich in apocrine sweat glands such as the axilla, perianal region and vulva. It most commonly occurs in postmenopausal women and presents as a superficial pigmented scaly macule, mimicking ...
Abidullah Mohammed M Assistant Professor, Department of Oral & Maxillofacial Pathology, GDCH , Hyderabad. A.P., India - - 2014
Leukoplakias are oral white lesions that have not been diagnosed as any other specific disease. They are grouped under premalignant lesions, now redesignated as potentially malignant disorders. Their significance lies in the fact that they have propensity for malignant transformation at a higher rate when compared to other oral lesions. ...
Skorin Leonid L Jr *OD, DO, MS †OD Department of Ophthalmology, Mayo Clinic Health System, Albert Lea, Minnesota (LS, Jr.); and MacDill Air Force Base, Tampa, Florida - - 2014
To present and discuss a case of herniation of subconjunctival orbital fat, a very rare but benign condition. An 84-year-old man presented to the eye clinic for a cataract surgery consultation but also had a secondary complaint about yellow lesions on the bulbar conjunctiva of both eyes. Examination with biomicroscopy ...
Lam Ching-Wan - - 2014
High-resolution proton nuclear magnetic resonance (NMR) spectrometry of biofluids has been increasingly used in laboratory diagnosis of various diseases. In this study, we extended the use of (1)H-NMR spectroscopy for laboratory diagnosis of exudative pleural effusions using pleural fluids. We compared this new NMR-based test with Light's criteria, the current ...
Mohammadi Ali Akbar AA Shiraz Burn Research Center, Division of Plastic and Reconstructive Surgery, Department of Surgery, Shiraz University of Medical Sciences, Shiraz, - - 2014
Trichoepithelioma is a rare benign skin lesion that originates from hair follicles. Trichoepitheliomas are mostly seen in the scalp, nose, forehead, and upper lip. We present a large family of Iranian origin with 15 individuals affected with multiple familial trichoepithelioma in four generations, and treated with three different methods. Trichoepithelioma ...
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