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Churg Andrew A Department of Pathology, Vancouver General Hospital, - - 2014
A new smoking-associated lesion has been described in the pathology literature over the last few years by various names including RBILD with fibrosis, smoking-related interstitial fibrosis, and airspace enlargement with fibrosis. The lesion consists of localized patches of paucicelluar interstitial fibrosis mixed with emphysema, and frequently forms a wedge shape ...
Colby Thomas T Mayo Clinic Arizona, - - 2014
Neither the pathologist nor the radiologist makes the diagnosis of IPF. It is a clinical diagnosis. Current recommendations are that the diagnosis of IPF follows multidisciplinary discussion (MDD) involving clinicians, radiologists and, if tissue is take, pathologists. According to the 2011 IPF guidelines, the diagnosis of IPF requires the pathologic ...
Zamel Ghada Al GA Former Resident, Department of Oral Medicine, University of Pennsylvania School of Dental Medicine, Philadelphia, - - 2014
Paraneoplastic pemphigus (PNP) is a mucocutaneous disease that occurs in association with an underlying neoplasm. Oral mucosal lesions may be the only manifestation of this condition, or they may be observed in association with cutaneous lesions. The prognosis of PNP is generally poor, and the disease is often fatal. This ...
Kishi Chikako C Department of Dermatology, Graduate School of Medicine, Gunma University, Maebashi, - - 2014
A 64-year-old Japanese woman was diagnosed as having Bowen's disease in the vulva. The histopathological findings revealed papillomatosis, koilocytosis and clumping cells with atypical nuclei. Human papillomavirus DNA was not detected on polymerase chain reaction using consensus primers. The lesion was successfully treated with topical imiquimod 5% cream after two ...
Ling Galina - - 2014
Background: Neonatal ascites is a rare entity, which is usually biliary, urinary, or chylous. Congenital hepatic fibrosis as part of the manifestations of autosomal recessive polycystic kidney disease (ARPKD) is usually a histological adjunct to the diagnosis of this mainly clinically renal entity in the neonatal period. Case-diagnosis: We describe ...
Pender D J DJ Department of Otolaryngology - Head and Neck Surgery,Columbia University Medical Center,New York,New - - 2014
Objective: To determine whether the distribution of membrane lesions associated with Ménière's disease is random, as might be expected from a pervasive process such as hydrops, or orderly, as might be expected if membrane resistance is graded. Method: A meta-analysis of temporal bone reports on 184 specimens demonstrating endolymphatic hydrops ...
Senaratne Thamarasi N TN Department of Microbiology, Faculty of Medicine, University of Peradeniya, Sri - - 2014
Dengue fever (DF) is a mosquito borne virus infection which is endemic to the tropical regions of the world. In Sri Lanka, the first sero-positive case was reported in 1960's; since then the island has experienced several outbreaks of DF/dengue haemorrhagic fever (DHF). The disease is more prevalent in some ...
Kassa Berhe Gebreseslassie - - 2014
Hydatidosis is a tapeworm infection caused by the larval stage of Echinococcus species. The organs most frequently affected are the liver and the lungs. Primary involvement of the skeleton is rare. The location of hydatid cysts in the tibia is seldom described in the medical literature, and its diagnosis is ...
Johnston Stephen Albert - - 2014
Cancer diagnosis in both dogs and humans is complicated by the lack of a non-invasive diagnostic test. To meet this clinical need, we apply the recently developed immunosignature assay to spontaneous canine lymphoma as clinical proof-of-concept. Here we evaluate the immunosignature as a diagnostic for spontaneous canine lymphoma at both ...
Cankaya Hülya - - 2014
Oral squamous cell carcinoma (OSCC) is the most prevalent cancer of the head and neck with over 500,000 new cases every year worldwide. The stage of disease at diagnosis is associated with the 5-year survival rate. Unfortunately, approximately two-thirds of patients are diagnosed with advanced disease with local and regional ...
Wuyts Wim A WA Unit for Interstitial Lung Diseases, Dept of Pulmonary Medicine, University Hospitals Leuven, Leuven, Belgium. Operative Unit of Pathology, S. Maria Nuova Hospital, Reggio Emilia, Italy. Section of Pathology, University Hospital of Modena, Modena, Italy. Section of Diagnostic Imaging, Dept of Surgery, University of Parma, Parma, Italy. Interstitial and Rare Lung Disease Unit, Ruhrlandklinik, University Hospital, University of Duisburg-Essen, Germany. Medical University Clinic, Canton Hospital Baselland and University of Basel, Liestal, - - 2014
Idiopathic pulmonary fibrosis (IPF), the most common and lethal of the idiopathic interstitial pneumonias, is defined by a radiological and/or pathological pattern of usual interstitial pneumonia (UIP). However, UIP is not synonymous with IPF as other clinical conditions may be associated with UIP, including chronic hypersensitivity pneumonitis, collagen vascular disease, ...
Babu D D Tata Memorial Hospital, Mumbai, - - 2014
Haemangiomas are one of the most common benign tumours. Clinicians come across haemangiomas of different subtypes at different locations in the body. They are often faced with the question of whether to treat them or leave it to the natural history of the disease. We present a case of the ...
Faria Adriane Reichert AR Santa Casa de Misericórdia Hospital, Curitiba, PR, - - 2014
In an unprecedented effort in the field of vitiligo, a global consensus resulted on a suggested new classification protocol for the disease. The main histopathological finding in vitiligo is the total absence of functioning melanocytes in the lesions, while the inflammatory cells most commonly found on the edges of the ...
van der Tol Linda L Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam Lysosome Center 'Sphinx', Amsterdam, - - 2014
Screening for Fabry disease (FD), an X-linked lysosomal storage disorder, reveals a significant number of individuals with a genetic variant of unknown significance without classical FD manifestations; these variants in the α-galactosidase A gene often result in a high residual leukocyte α-galactosidase A and it is unclear whether these individuals ...
Kocabeyoglu Sibel S Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, - - 2014
To report the clinical and in vivo confocal microscopic (IVCM) findings of corneal deposits in a patient with tyrosinemia type II. The pretreatment and 1-month posttreatment slit-lamp examination and IVCM findings of a patient with tyrosinemia type II are described. A 12-year-old girl diagnosed with tyrosinemia type II was evaluated ...
Petrović Dragan - - 2014
Sinus histiocytosis with massive lymphadenopathy is a rare benign self-limiting disease of unknown etiology. The salivary gland involvement, indicating the extranodal character of the disease, often presents a diagnostic dilemma requiring immunohistochemical staining of surgically removed tumor to confirm the diagnosis. We report a 43-year-old man presented with an asymptomatic ...
Ladak Aleem A Breast Unit, North Manchester General Hospital, Manchester, - - 2014
Pigmented extramammary Paget's disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget's disease affecting skin that is rich in apocrine sweat glands such as the axilla, perianal region and vulva. It most commonly occurs in postmenopausal women and presents as a superficial pigmented scaly macule, mimicking ...
Skorin Leonid L Jr *OD, DO, MS †OD Department of Ophthalmology, Mayo Clinic Health System, Albert Lea, Minnesota (LS, Jr.); and MacDill Air Force Base, Tampa, Florida - - 2014
To present and discuss a case of herniation of subconjunctival orbital fat, a very rare but benign condition. An 84-year-old man presented to the eye clinic for a cataract surgery consultation but also had a secondary complaint about yellow lesions on the bulbar conjunctiva of both eyes. Examination with biomicroscopy ...
Lam Ching-Wan - - 2014
High-resolution proton nuclear magnetic resonance (NMR) spectrometry of biofluids has been increasingly used in laboratory diagnosis of various diseases. In this study, we extended the use of (1)H-NMR spectroscopy for laboratory diagnosis of exudative pleural effusions using pleural fluids. We compared this new NMR-based test with Light's criteria, the current ...
Shah Neha P NP Senior House Officer in Oral and Maxillofacial Surgery, John Radcliffe Hospital, Oxford University Hospitals, Oxford, England. Electronic address: - - 2014
We report a case of an orofacial lesion in Crohn's disease successfully treated with tacrolimus ointment. A 22-year-old woman with Crohn's disease presented with a discharging lesion on the right side of her face. Intraorally, there was a resultant loss of the sulcal depth. She reported a 1-year history of ...
Umans Hilary H Albert Einstein College of Medicine and Lenox Hill Radiology Imaging and Associates, Bronx, NY, USA, - - 2014
To identify the variety of second and third intermetatarsal space (IS) lesions that may coexist with and without adjacent metatarsophalangeal joint (MTP) plantar plate (PP) tears. One hundred forefoot MRIs in 96 patients with metatarsalgia obtained between 30 September 2011 and 21 July 2012 using 1.5- or 3-T MRI were ...
Lonnen James J OBRUS Microbiology Services, Department of Infection, Immunity & Inflammation, University of Leicester, Medical Sciences Building, P.O. Box 138, University Road, Leicester LE1 9HN, United - - 2014
To assess the efficacy of a novel ultraviolet (UV) lens device on the killing of Acanthamoeba cysts and the impact of efficacious doses of UV upon soft contact lens parameter and material characteristics. Prospective, in vitro, experimental study of a device. A UV lens device was constructed and used to ...
Pelegrín Laura L Department of Ophthalmology, Hospital Clínic de Barcelona, Barcelona, Spain. Electronic address: - - 2014
A 72-year-old man presented with signs on uveítis. Biopsy of an iris lesion established the diagnosis of uveal MALT lymphoma with presumed choroidal involvement.
Triki Habiba Zmerli HZ Tunisian National Agronomic Institute (INAT), IRESA - Carthage University, U.R Marine Biology (FST El Manar I), 43 Avenue Charles Nicolle, 1082 Tunis, Tunisia. Electronic address: - - 2014
This study investigated the spatial distribution of Alexandrium pseudogonyaulax resting cysts in recently-deposited sediment of Bizerte lagoon (South-Western Mediterranean, Tunisia). This lagoon is the subject of many anthropogenic impacts, such as holding important fishing and aquaculture activities. A. pseudogonyaulax has been shown to produce Goniodomin A, which is a biologically-active ...
Jeromel Miran M Clinical Institute of Radiology, University Medical Centre Ljubljana, Ljubljana, - - 2014
Most vertebral haemangioma are asymptomatic and discovered incidentally. Sometimes the symptomatic lesions present with radiological signs of aggressiveness and their appearance resemble other aggressive lesions (e.g. solitary plasmacytoma). We present a patient with large symptomatic aggressive haemangioma like lesion in 12(th) thoracic vertebra in which a magnetic resonance spectroscopy (MRS) ...
Gibbons Stephen M SM Nottingham University Hospitals, Nottingham, - - 2014
Chylothorax is a rare anatomical disruption of the thoracic duct associated with a significant degree of morbidity and mortality. Diagnosis usually relies upon lipid analysis and visual inspection of the pleural fluid. However, this may be subject to incorrect interpretation. The aim of this study was to compare pleural fluid ...
Oklu Rahmi R Department of Imaging, Division of Vascular Imaging and Intervention (R.O.); Harvard Medical School (R.O., J.R.S., H.A., M.T.W.), Boston, Massachusetts. Electronic address: - - 2014
To investigate the presence and location of extracellular traps (ETs) in atherosclerotic plaques and to determine whether they are spatially associated with inflammatory cells and the lipid core. Human carotid atherosclerotic plaques were collected from seven patients after surgical endarterectomy. Sequential tissue sections were stained with hematoxylin-eosin or subjected to ...
Tan Cheng - - 2014
Background:Dermoscopy has been shown to be a promising method to facilitate the diagnosis of lichen planus (LP) outside of China.Objective:To investigate the spectrum of dermoscopic patterns in Chinese LP patients.Methods:The clinical data and dermoscopic patterns of nine LP cases with a total of 43 lesions were evaluated.Results:To the naked eye, ...
Bannon Aidan A Centre for Medical Education, Queen's University Belfast, Belfast, - - 2014
We report the case of a 17-year-old girl who presented to the accident and emergency department with dysuria and foul smelling, bloody discharge from her umbilicus. The definitive diagnosis was that of a patent urachus, which is a fistulous communication between the bladder and the umbilicus, usually diagnosed in early ...
Srikantharajah Mukunthan M School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, - - 2014
A 23-year-old man presented with a 6-week history of fevers, cervical lymphadenopathy and fatigue. A CT of the neck, chest, abdomen and pelvis showed left cervical lymphadenopathy, enlarged lymph nodes in the axilla and groin and hepatomegaly. A left cervical excisional lymph node biopsy was undertaken and the histopathological findings ...
Kashyap Surender S 0000-0002-8019-1913 Kalpana Chawla Government Medical College, Karnal, Haryana 132001, - - 2014
Despite the rapid advancement in diagnostic and therapeutic modalities, endobronchial tuberculosis (EBTB), defined as tuberculous infection of the tracheobronchial tree, continues to remain challenging for clinicians. Nonspecific respiratory symptoms along with normal chest radiograph in 10-20% of cases may be alleged for the diagnostic delay. Variable diagnostic yield with sputum ...
Zhu Lei L Services Computing Technology and System Lab, Cluster and Grid Computing Lab, School of Computer Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, - - 2014
Silicosis remains one of the most harmful occupational respiratory diseases. It threatens the workers exposed to dust environment. Chest radiograph is the main available image source for silicosis diagnosis according to the diagnostic criteria of pneumoconiosis (DCP). Automatic detection and recognition of silicosis in chest radiograph has great importance on ...
Eloyan Ani A Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of - - 2014
Brain lesion localization in multiple sclerosis (MS) is thought to be associated with the type and severity of adverse health effects. However, several factors hinder statistical analyses of such associations using large MRI datasets: 1) spatial registration algorithms developed for healthy individuals may be less effective on diseased brains and ...
Toklu Yasin - - 2013
A 50 year-old male patient was referred to our clinic due to a floating mass in the right eye. The uncorrected visual aquity was 10 / 10 in both eyes.The patient did not have any systemic disorder and trauma history. His ophthalmological examination revealed an unremarkable anterior segment with no ...
Townsend Wendy M - - 2013
Objective-To determine the prevalence of uveal cysts and pigmentary uveitis (PU) in Golden Retrievers in 3 Midwestern states. Design-Prospective cross-sectional study. Animals-164 American Kennel Club-registered Golden Retrievers in the states of Illinois, Indiana, and Michigan. Procedures-For all dogs, biomicroscopic and binocular indirect ophthalmoscopic examinations of both eyes were performed after ...
Shah Kabeer - - 2013
Keratoacanthoma (KA), an epithelial neoplasm occurring in sun-exposed skin of the elderly, is considered a well-differentiated form of invasive squamous cell carcinoma (SCC) that often follows a course of spontaneous regression. Distinguishing KA from invasive SCC or pseudocarcinomatous epithelial hyperplasia ensures proper diagnosis, treatment and management. For some time, perforating ...
van der Stoep Marco - - 2013
While numerous studies have aimed to develop strategies to inhibit the development and progression of atherosclerosis, recent attention has focussed on the regression of pre-existing atherosclerotic plaques. As important regulator of total body cholesterol homeostasis, the liver X receptor (LXR) could possibly be an important target to induce regression. Here, ...
Shitara Danielle - - 2013
The aim of this study was to evaluate the practical importance of the presence of shiny white streaks (SWS) (chrysalis or crystalline structures in polarized dermoscopy) for suspicion of malignancy, diagnosis of melanoma, and pre-operative estimation of Breslow thickness and its correlation with total dermoscopy score (TDS). SWS were present ...
Fisher Valerie - - 2013
Hypertrophic lichen planus (LP), also known as LP verrucosus, is a rare disorder that presents as verrucous plaques, typically on the lower extremities and ankles. This variant differs from the common presentation of LP, which appears as flat, polygonal, pink-purple papules spread diffusely on the flexor wrists, trunk, shins, and ...
Kilvington Simon - - 2013
PURPOSE. TO INVESTIGATE EXPERIMENTAL VARIABLES IN THE DEVELOPMENT OF STANDARDISED METHODS TO ASSESS THE EFFICACY OF CONTACT LENS DISINFECTION SYSTEMS AGAINST THE TROPHOZOITE AND CYSTS OF ACANTHAMOEBA SPP. METHODS. A. CASTELLANII (ATCC 50370), A. POLYPHAGA (ATCC 30461) AND A. HATCHETTI (CDC: V573) were adapted to axenic culture and used to ...
Kuhn Sonia E - - 2013
Sixteen adult captive bald eagles (Haliaeetus leucocephalus) underwent a complete bilateral ocular examination to assess normal ocular parameters and describe ophthalmic lesions. Tear production was measured with the Schirmer tear test 1 and intraocular pressure was measured with applanation tonometry. The menace response was normal bilaterally in 13 of 16 ...
Nourani Khojasteh Habib - - 2013
Congenital homocysteinemia is a genetic disease with various clinical manifestations such as thrombosis, lens dislocation and mental retardation and osteoporosis, so early diagnosis is important for decreasing the mortality and morbidity especially in pediatric populations. Here we describe a child with a presentation of coma with a past history of ...
Sampath Santhosh S Department of Nuclear Medicine, Surgical Gasteroenterology Division, Postgraduate Institute of Medical Education and Research, Chandigarh, - - 2013
Diffuse infiltration by a primary or metastatic malignancy into the submucosa and muscularis of the stomach (linitis plastica [LP]) has been described in literature. The authors present a case of LP caused by primary adenocarcinoma of the stomach, showing diffuse Fluorine-18 fluorodeoxyglucose uptake in the thickened wall of the stomach.
Wang Yumin - - 2013
BACKGROUND: Apolipoprotein E (apoE) levels have been shown to be elevated in pleural effusion of patients with non-small cell lung cancer (NSCLC). However, the diagnostic value of apoE in pleural effusion in NSCLC has not been well validated and established. METHODS: Samples of malignant pleural effusions (MPE) and benign effusions ...
Zhou Xibin X Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, - - 2013
To report a case of presumed acquired retinal astrocytoma in association with anterior uveitis. A 29-year-old man presented with mutton fat keratic precipitates in the inferiorlower cornea, with complicated cataract and a circumscribed, solitary, yellowish-white retinal lesion in the right eye. Phacoemulsification with intraocular lens implantation was performed, with election ...
Liau Jau-Yu - - 2013
AIMS: Both lupus panniculitis (LP) and subcutaneous panniculitis-like T-cell lymphoma (SPTCL) are characterized by subcutaneous lobular lymphocytic infiltrates, and they are sometimes difficult to differentiate. Recently, plasmacytoid dendritic cells (PDCs) were found to be present in various types of cutaneous lupus erythematosus lesions, including LP, and are supposed to play ...
Vijay Ajay Kumar - - 2013
PURPOSE: To evaluate the amoebicidal efficacy of protamine with polyhexamethylene biguanide (PHMB) and ethylenediamine tetraacetic acid (EDTA). METHODS: The International Organization for Standardization 14729:2001 procedure was modified to test amoebicidal activity. Acanthamoeba cells were inoculated into dilutions of protamine alone (57 to 228 μM) or in combination with PHMB/EDTA and ...
Ali Rizvi Syed Wajahat - - 2013
Bilateral persistent hyperplastic primary vitreous (PHPV) is a rare disorder of eye. It is one of the most important differential diagnoses of retinoblastoma, hence early and accurate diagnosis is important. We here report a case of an 11-month-old child which was referred to ocular OPD with complaints of bilateral leukocoria. ...
Ducrocq Julie - - 2013
Besnoitia tarandi has been documented in free-ranging reindeer and caribou (Rangifer tarandus spp.) since 1922 throughout their arctic and subarctic ranges; however, very little is known about its epidemiology. We evaluated variables associated with B. tarandi prevalence and cyst density with the use of barren-ground caribou (Rangifer tarandus) from two ...
Lade Nitin Ramchandra - - 2013
Linear lichen planus (LP) is commonly seen as an effect of the koebner phenomenon and can occur in any site. However, LP in a whorl pattern along Blaschko lines is rarely mentioned in the literature. We highlight this rare form in a 32-year-old female with multiple hyperpigmented lesions with various ...
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