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Kim Tae Hyung TH *Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea; †Yeouido Oracle Cosmetic Dermatosurgery Clinic, Seoul, Korea; and ‡Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, - - 2014
Matrix metalloproteinase (MMP), tissue inhibitor of metalloproteinase (TIMP), and membrane-type 1 matrix metalloproteinase (MT1-MMP) are thought to be involved in the destruction of basement membrane and stromal invasion by cancer cells. The aim of this study was to identify and compare MMP and TIMP expression in internal malignancies and paired ...
Chen Wei W Departments of *Pathology †Gastroenterology, The Ohio State University Wexner Medical Center, Columbus, - - 2014
Core-needle biopsy remains essential for diagnosis of cirrhosis; however, evaluation of fibrosis in such biopsies is often challenging due to the fragmented nature of cirrhotic liver specimens. It is also common to see portions of liver capsules present in the biopsy which adds to the diagnostic challenge. The distinction between ...
Fremlin G A GA Department of Medicine, University Hospitals Bristol, Bristol, Avon, - - 2014
Pyoderma gangrenosum (PG) is a rare, non infectious, inflammatory disease characterized by neutrophilic infiltration of the dermis and destruction of tissue. PG is a diagnostic challenge which can lead to late diagnosis, delayed treatment and detrimental surgical interventions. Our case additionally describes a presentation not previously reported, affecting deep muscle ...
Lozano Martínez G A GA Servicio de diagnóstico por la imagen,Hospital de la Santa Creu i Sant Pau , Barcelona, España. Electronic address: - - 2014
Chondrosarcomas are malignant bone tumors originating in cartilage. Chondrosarcoma is the third most common malignant bone tumor after multiple myeloma and osteosarcoma. About 75% of chondrosarcomas are primary lesions. The remaining 25% belong to special categories such as histologic variants and secondary forms. A secondary chondrosarcoma is one that appears ...
Guzik Grzegorz G Department of Oncological Orthopaedics, Specialist Hospital in Brzozów - Podkarpacie Oncological Centre, - - 2014
Background. Primary bone lymphomas are very rare. The diagnosis is based on a histopathological examination and imaging studies where other disease foci should be excluded. The lymphomas are most often found in the axial skeleton, pelvis, femur and humerus. The tumour causes extensive lytic bone destruction with soft tissue infiltration. ...
Fu Xinge X Department of Pathology, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, - - 2014
Osteoblastoma is a benign bone-forming neoplasm that occurs commonly in the posterior elements of the spine and the sacrum. However, so far there has been no report of intradural osteoblastoma described in the literature. We present a unique case of intraspinal dural-based osteoblastoma with aneurysmal bone cyst-like change without evidence ...
Northrup Benjamin E BE Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO. Electronic address: - - 2014
Many diseases result in polyostotic bone lesions including benign entities, benign entities with malignant potential, intermediate entities, and malignant entities. Imaging plays a key role in identifying complications of these disorders, most importantly malignant transformation of a benign lesion. The most common polyostotic bone lesions are reviewed and examples of ...
Sharma Leena L Northwestern University, Chicago, - - 2014
Little is known about early knee osteoarthritis (OA). The significance of lesions on magnetic resonance imaging (MRI) in older persons without radiographic OA is unclear. Our objectives were to determine the extent of tissue pathology by MRI and evaluate its significance by testing the following hypotheses: cartilage damage, bone marrow ...
Brandén Eva E Department of Respiratory Medicine, Gävle Hospital, Karolinska Institutet, Stockholm, Sweden ; Centre for Research and Development Uppsala University/County Council of Gävleborg, Sweden ; Karolinska Institutet, Stockholm, - - 2014
Core biopsies are valuable in obtaining sufficient tissue to ensure diagnosis of diseases in the thorax. To evaluate the complication rate and the diagnostic yield in computer tomography (CT)-guided core biopsies performed in a county hospital in Sweden. Medical journals, spirometry results, pathology reports and CT scans were reviewed in ...
Batista Carolina Mayana de Avila CM SES, Regional Hospital of Asa Norte, Brasília, DF, - - 2014
Idiopathic Atrophoderma of Pasini and Pierini (IAPP) is a rare, exclusively cutaneous disease. It is more frequent in females, with incidence peak in the second and third decades of life. The etiopathogenesis remains unknown. IAPP most commonly affects the back, abdomen and proximal regions of the limbs. Lesions may be ...
Miranda Zambrano A David AD Virgen del Rocío Hospital, Seville, - - 2014
Elastofibroma is a benign fibroproliferative tumor of unknown origin and pathogenesis. It usually appears in the subscapular or infrascapular area. It is extremely rare in the spinal area, and it is most common in middle-aged women. In most cases, it is asymptomatic. Its diagnosis is based on nuclear MRI, where ...
El-Khalawany Mohamed M Department of Dermatology, Al-Azhar University, Cairo, Egypt. Electronic address: - - 2014
Prurigo is a common skin condition characterized by vigorous scratching. Although ulceration is not uncommon in prurigo, a perforating-like lesion was not previously reported. In this study we described series of cases of prurigo with perforating-like lesions and discussed its relation to acquired perforating dermatoses. The study included 32 cases, ...
Badial Peres R PR Department of Veterinary Clinical Science, School of Veterinary Medicine and Animal Science, UNESP - Univ Estadual Paulista, Botucatu, São Paulo, - - 2014
Hereditary equine regional dermal asthenia (HERDA) is an autosomal recessive disorder affecting quarter horses (QHs); affected horses exhibit characteristic skin abnormalities related to abnormal collagen biosynthesis. To characterize the thickness and morphological abnormalities of the skin of HERDA-affected horses and to determine the interobserver agreement and the diagnostic accuracy of ...
Palmieri C C School of Veterinary Science, The University of Queensland, QLD, - - 2014
Cutaneous mucinosis is a cutaneous disorder described in humans, dogs, and rarely cats but never reported in birds. Twenty-six brown egg-laying chickens between ages 43 and 46 weeks had a history of feather loss, scaly, dry skin, weight loss, and decreased egg production. Microscopic findings in the skin included fragmentation ...
Huang Yun-Chen YC Department of Otolaryngology, Head and Neck Surgery, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, Taipei, - - 2014
Giant cell tumour (GCT) in the parotid region is a rare lesion whose origin can be divided into three compartments: giant cell tumour of the salivary gland (GCT-SG), giant cell tumour of the bone (GCT-bone) and giant cell tumour of the soft tissue (GCT-ST). A low risk of malignancy has ...
Bianchi Francesca Antonella FA Department of Surgical Sciences (Head: Prof. G. Ramieri), Maxillofacial Surgery Section, San Giovanni Battista Hospital, University of Turin, Corso A.M. Dogliotti 14, Turin 10126, Italy. Electronic address: - - 2014
A 31-year-old woman presented with a large oro-nasal communication (ONC), loss of vomer and significant nasal cartilage and nose deformity. Physical examination of the patient revealed a typical midline destructive lesion (MDL) with nasal septum and hard/soft palate perforation with a friable granular surface and a large amount of necrotic ...
Hicks Caitlin W CW Department of General Surgery, Johns Hopkins Hospital, Baltimore, MD 21287, United - - 2014
Heterotopic ossification (HO) refers to the formation of bone in non-ossifying tissue. Heterotopic mesenteric ossification is a rare form of HO that is characterized by the formation of an ossifying pseudotumour at the base of the mesentery, usually following abdominal surgery. We describe a case of mesenteric HO in a ...
Chiba Ko K Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA; Department of Orthopedic Surgery, Nagasaki University School of Medicine, Nagasaki, Japan. Electronic address: - - 2014
Subchondral cysts are deeply related to the pathogenesis of osteoarthritis (OA), but the factors contributing to cyst formation are not well known. A three-dimensional analysis of subchondral cysts at the micro-structural level was conducted using a high-resolution peripheral quantitative CT (HR-pQCT), and their relationships with cartilage attrition and subchondral bone ...
Erickson Benjamin P BP Bascom Palmer Eye Institute , Miami, Florida , USA - - 2014
Abstract A 61-year-old man presented with a 2.5 cm fungating skin lesion above the right medial canthus, accompanied by fluctuance and subtle inferotemporal globe displacement. The tumor had erupted 2 months previously and grown rapidly. Computed tomography (CT) revealed a 4.2 × 2.8 × 2.1 cm exophytic mass of the right orbit, superimposed on chronic dacryocystitis. ...
Kontogeorgakos Vasileios A VA Department of Orthopaedic Surgery and Musculoskeletal Trauma, University Hospital of Thessaly, Larissa, - - 2014
Langerhans cell histiocytosis is a rare neoplastic proliferative disorder of the Langerhans cells. The clinical course is variable, ranging from a low symptomatic single bone lesion to fatal multiple organ involvement. Rarely, the sternum can be the first and single location of the disease. We report on a 12-year-old boy ...
Hwang Ki-Eun KE Department of Internal Medicine, Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, - - 2014
Malignant fibrous histiocytoma (MFH), a type of sarcoma, is a malignant neoplasm with uncertain origins that arise from both the soft tissues and the bone. The occurrence of MFH on the chest wall is extremely rare. We hereby report a case of a 72-year-old woman who was incidentally detected with ...
Sousa Natália Guimarães Kalatzis NG Department of Restorative Dentistry, Araraquara Dental School, UNESP-Univ. Estadual Paulista, Rua Humaitá, 1680, 14801-903 Araraquara, SP, - - 2014
To evaluate the expression of matrix metalloproteinase inducer (EMMPRIN) and its correlation with the expression of matrix metalloproteinases (MMPs)-1, -2 and -9 during the development of periapical lesion in mice. Periapical lesions were induced in the lower first molars of mice and after 7, 14, 21 and 42 days the ...
Simon Maciej Jk - - 2014
The aim of this large collective and meticulous study of primary bone tumours and tumourous lesions of the hand was to enhance the knowledge about findings of traumatological radiographs and improve differential diagnosis. This retrospective study reviewed data collected from 1976 until 2006 in our Bone Tumour Registry. The following ...
Rice Brittany B Fourth Year Podiatry Student, Samuel Merritt University California School of Podiatric Medicine, Oakland, - - 2014
Metastases to the bones in the foot are extremely uncommon, occurring in approximately 0.01% of all metastatic bone disease. We describe a case of an 82-year-old female with a metastatic pulmonary sarcomatoid carcinoma lesion to the midfoot. This rare and aggressive pulmonary malignancy has a poor prognosis. The purpose of ...
Ali Mohammad Javed MJ *Dacryology Service and †Ocular Pathology Service, L.V. Prasad Eye Institute, Hyderabad, Andhra Pradesh, - - 2014
Myxomas are rare benign tumors of primitive mesenchymal origin that usually arise from the soft tissues and occasionally from the bones. Bony myxomas predominantly arise from the jaw bone and hence are also known as gnathic myxomas. Any other bony myxomas are termed as extragnathic. In view of rarity, uncertain ...
Markhardt B Keegan BK Department of Radiology, Community Division, University of Wisconsin, Madison, WI. Electronic address: - - 2014
Discussion of articular cartilage disease detection by MRI usually focuses on the presence of bright signal on T2-weighted sequences, such as in Grade 1 chondromalacia and cartilage fissures containing fluid. Less emphasis has been placed on how cartilage disease may be manifested by dark signal on T2-weighted sequences. The appearance ...
Ji Jong-Hun JH Department of Orthopedic Surgery, College of Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea, 520-2, Daehung-dong, Jung-gu, Daejeon, 302-803, South - - 2014
Synovial chondromatosis is classified as either primary or secondary. Primary synovial chondromatosis results from a proliferation of chondrocytes in the synovial membrane leading to the formation of cartilaginous loose bodies. Secondary synovial chondromatosis is a rare condition characterized by the growth of separated particles from the articular cartilage or osteophytes ...
Roghi Marco M Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Largo Rosanna Benzi 10, Pad IV, 16132, Genova, Italy. - - 2014
Periapical cemento-osseous dysplasia (PCOD) is a rare benign lesion, often asymptomatic, in which fibrous tissue replaces the normal bone tissue, with metaplasic bone and neo-formed cement. We present a rare case of mandibular PCOD in a woman of 55 years, who presented with moderate swelling and mobility of teeth 32-33-34. ...
Tanaka Tetsuhiro T Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, - - 2014
Chloride secretion driven by calcium-dependent chloride channels has a major impact on cyst enlargement in polycystic kidney disease. Buchholz et al. studied the functional role of anoctamin 1 (ANO1), a recently identified calcium-activated chloride channel, in kidney cyst growth, using principal-like cells forming cysts within a collagen matrix and an ...
Pizzichetta Maria A MA *Division of Medical Oncology C, Preventive Oncology, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy; †Division of Pathology, Centro di Riferimento Oncologico, National Cancer institute, Aviano, Italy; ‡Dermatology Research Centre, the University of Queensland, School of Medicine, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Australia; §Department of Dermatology, University of Siena, Siena, Italy; and ¶Department of Dermatology, Medical University of Graz, Graz, - - 2014
: It has been suggested that both negative pigment network (NPN) and shiny white streaks (SWS) were related to an increase of dermal collagen. To study precisely the dermoscopic-histopathologic correlation of NPN and SWS, we have performed a dermoscopic-pathological correlation study. A total of 25 skin lesions dermoscopically characterized by ...
Gregory James R - - 2014
Chondroblastoma is a rare, benign primary bone tumor that usually occurs at the epiphysis of long bones. The authors present an example of the diagnosis and successful treatment of this neoplasm in an exceedingly rare location in the distal phalanx. Clinical and radiographic outcomes after 68 months of follow-up are ...
Sathyanarayana B D BD Departments of Dermatology, Venereology and Leprosy, Adichunchanagiri Institute of Medical Sciences, BG Nagara, Bellur, Karnataka, - - 2014
Giant congenital nevomelanocytic nevus (GCNN) is a rare variant of congenital melanocytic nevus measuring >20 cm in size that often has a garment-like distribution. Regular follow up is recommended because of a risk of melanoma transformation of 4.6%. We report a 14-year-old boy with gradual regression of giant congenital melanocytic ...
Kundu Zile Singh ZS Department of Orthopaedics, Pt B D Sharma PGIMS, Rohtak, Haryana, - - 2014
Osteosarcoma is the most common primary osseous malignancy excluding malignant neoplasms of marrow origin (myeloma, lymphoma and leukemia) and accounts for approximately 20% of bone cancers. It predominantly affects patients younger than 20 years and mainly occurs in the long bones of the extremities, the most common being the metaphyseal ...
Argon Asuman A Department of Pathology, Izmir Bozyaka Training and Research Hospital , Izmir , - - 2014
Abstract Although osteosarcoma is the most common primary malignant tumour of bone, osteosarcomas of jaw are rare. In osteosarcomas of jaw, evaluating the clinicopathological factors affecting the prognosis is not easy because of different approaches to diagnosis, treatment, and follow-up. This study reviewed 14 cases of JOS that were diagnosed ...
Wang He - - 2014
The optimal course of clinical follow-up after a diagnosis of breast papillary lesion on a core needle biopsy (CNB) remains elusive. In particular, no reports in literature have addressed this question in African-American population. We describe our experience with breast papillary lesions in a primarily African-American population. A search of ...
Birk John W JW Division of Gastroenterology and Hepatology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030-1845, USA, - - 2014
Second harmonic generation (SHG) is a novel imaging technology that could provide optical biopsy during endoscopy with advantages over current technology. SHG has the unique ability to evaluate the amount of extracellular matrix collagen protein and its alignment. Hematoxylin- and eosin-stained slides from colon biopsies (normal, low-grade dysplasia (LGD), high-grade ...
Jastifer James R JR Saint Alphonsus Coughlin Foot & Ankle Clinic, Boise, ID, - - 2014
Patient dissatisfaction following surgical correction of hallux valgus remains a clinical problem. The aim of this study was to investigate articular erosion patterns of the first metatarsal head in patients with hallux valgus, to evaluate if the cartilage damage was associated with the degree of hallux valgus deformity, and to ...
Ahmadi Mohammad Saeed MS Department of Otorhinolaryngology, Besat Hospital, Hamadan University of Medical Sciences, Hamedan, - - 2014
Osteomas are asymptomatic and rare slow growing bony tumors in temporal bone, and should be taken into account in differential diagnosis of the osteolytic solitary skull lesions. Sometimes is associated with pain and functional loss. Only a few cases have been reported. We describe a case of an osteoid osteoma ...
Mridha A R AR All India Institute of Medical Sciences, Department of Pathology, Ansari Nagar, New Delhi-110029, India. - - 2014
Epithelioid hemangioma (EH) is a rare benign vascular lesion of soft tissue and bone, characterized by endothelial cells with epithelioid or histiocytoid appearance. Though tubular bones, flat bones, vertebra and short bones are common sites for this lesion, the epiphyseal involvement is extremely rare. We present an unusual case of ...
Satish Kumar K Oral Medicine and Radiology, Vydehi Institute of Dental Science and Research Center, Bangalore, Karnakata, - - 2014
Traumatic bone cyst (TBC) is an uncommon non-epithelial lined cavity of the jaws. Traumatic bone cysts have been reported in the literature under a variety of names: solitary bone cyst, haemorrhagic bone cyst, extravasation cyst and simple bone cyst. The multitude of names applied to this lesion implies the lack ...
Fernandes Tania Rita Moreno de Oliveira TR Universidade Federal do Vale do São Francisco, Petrolina, PE, - - 2014
Leprosy is clinically characterized by involvement of peripheral nerves and skin. The immunological profile of the individual defines the diversity of clinical manifestations, from skin disorders to systemic manifestations, especially the articulation ones, common in multibacillary forms, which may mimic collagen diseases and often posing diagnostic difficulties in endemic areas. ...
Colangeli S S Department of Oncological and Degenerative Spine Surgery, Rizzoli Orthopedic Institute, Bologna, Italy. - - 2014
Spinal bone metastases may be lytic or sclerotic lesions. Sometimes aneurismal bone cyst (ABC)-like areas (also called "secondary ABC") can be found in giant-cell tumors, osteoblastomas and chondroblastomas but are rare in metastatic tumors. A retrospective study on 518 patients surgically treated for metastatic lesions of the spine from 1995 ...
Fuccio Lorenzo L Gastroenterology Unit, Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, - - 2014
Endoscopic ultrasound (EUS)-guided fine needle aspiration has emerged as the procedure of choice to obtain samples to reach a definitive diagnosis of lesions of the gastrointestinal tract and of adjacent organs. The obtainment of a tissue core biopsy presents several advantages that can substantially contribute to the widespread diffusion of ...
Kumar Manoj M Senior Resident, Department of Orthopedics, MGIMS , Sewagram, Wardha, Maharshtra, India - - 2014
Osteochondromas are commonly encountered benign tumours and they are characterized by cartilage capped bony growths that project from the surface of the affected bone. Osteochondromas tend to grow eccentrically rather than centrifugally. We are reporting a case of an 18-year-old male, who had presentation of a large, hard, irregular swelling ...
Dunet B B Service d'orthopédie traumatologie, hôpital Pellegrin, place Amélie-Raba-Leon, 33076 Bordeaux cedex, France. Electronic address: - - 2014
We report the case of a 37-year-old patient presenting with knee pain and recurrent effusion without instability due to an intra-articular hemangioma in the posterior compartment of the knee. MRI showed features suggesting a diagnosis of hemangioma. Arthroscopic excision of the tumor was performed and the diagnosis was confirmed histologically. ...
Herget G W - - 2014
The Enchondroma is a common, benign, cartilage forming tumour. They usually occur as a single, asymptomatic lesion. Occasionally patients present with multiple enchondromas which is generally defined as enchondromatosis. This entity encompasses several different subtypes including Ollier disease and Maffucci syndrome (enchondromatosis associated with soft tissue haemangiomas) as the most commons. ...
Ansari Mohammed Tahir MT Assistant Professor of Orthopaedics, Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, India. Electronic address: - - 2014
Schwannomas of osseous origin are rare, and schwannomas of the short tubular bones are even rarer. These benign-looking tumors are difficult to diagnose using imaging alone. However, histopathologic evaluation of a biopsy specimen can establish the diagnosis by identifying Antoni type A and B zones. Curettage and bone grafting will ...
Friesenbichler Joerg J Department of Orthopaedic Surgery, Medical University of Graz, Auenbruggerplatz 5, 8036, Graz, - - 2014
Primary malignant bone tumours and soft tissue sarcomas of the chest wall are exceedingly rare entities. The aim of this study was a retrospective two-institutional analysis of surgical therapy with respect to the kind and amount of the resection performed, the type of reconstruction and the oncological outcome. Between September ...
Gondim Teixeira P A PA Service d'imagerie Guilloz, hôpital Central, CHU de Nancy, 54000 Nancy, France; Université de Lorraine, IADI, UMR S 947, Tour Drouet, rue du Morvan, 54511 Vandœuvre-lès-Nancy, France. Electronic address: - - 2014
To compare the enhancement dynamics of osteoid osteomas with other benign and malignant lytic bone lesions using CT perfusion. CT perfusion parameters of 15 patients with a final diagnosis of osteoid osteoma, 15 patients with lesions that mimic osteoid osteomas and 26 patients with other bone lytic lesions were compared. ...
Sharma Leena L Northwestern University, Chicago, - - 2014
Objective. Little is known about early knee osteoarthritis (OA). The significance of MRI lesions in older persons without radiographic OA is unclear. Our objectives were to determine extent of tissue pathology by MRI and evaluate its significance by testing the hypotheses: cartilage damage, bone marrow lesions (BMLs), and meniscal damage ...
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