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Boas F Edward FE Interventional Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA, - - 2014
Perfusion CT of the liver typically involves scanning the liver at least 20 times, resulting in a large radiation dose. We developed and validated a simplified model of tumor blood supply that can be applied to standard triphasic scans and evaluated whether this can be used to distinguish benign and ...
Adachi Makoto M Department of Oral and Maxillofacial Surgery, Asahi University Murakami Memorial Hospital, Gifu 500-8523, - - 2014
Cyst-like lesions in the mandible rarely develop into malignancies, and the reported incidence is between 0.3 and 2%. The present study describes a rare case of primary intraosseous squamous cell carcinoma of the mandible arising from an odontogenic cyst. A 59-year-old female was referred to Asahi University Murakami Memorial Hospital ...
Duraipandian Shiyamala S Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576. - - 2014
Raman spectroscopy measures the inelastically scattered light from tissue that is capable of identifying native tissue biochemical constituents and their changes associated with disease transformation. This study aims to characterize the Raman spectroscopic properties of cervical tissue associated with the multi-stage progression of cervical precarcinogenic sequence. A rapid-acquisition fiber-optic near-infrared ...
Bal Mv - - 2014
SUMMARY Invasive cervical resorption (ICR) is a rare external dental resorption with unknown etiology; it progresses asymptomatically in the cervical area of the permanent teeth. Lesions are mostly misdiagnosed as internal resorption or caries, which leads to erroneous treatments. This case report presents the clinical and radiological diagnosis, as well ...
Magaña Mario M *Hospital General de México "Eduardo Liceaga," S.S, Mexico City, Mexico; †School of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico; and ‡Centre for Dermatology & Dermatopathology, Mexico City, - - 2014
: Congenital melanocytic nevus (CMN) is a hamartomatous disease for which many attempts at classification have been proposed. This disease is relevant not only because of its functional and esthetic implications but also because it is a well-documented precursor to malignant melanoma. We performed a clinical and pathological prospective study ...
Kasi Sundeep K SK *Department of Ophthalmology, University of California San Francisco, San Francisco; †California Pacific Medical Center, San Francisco; ‡Department of Ophthalmology, Stanford University School of Medicine, Stanford; §West Coast Retina Medical Group, San Francisco; and ‖Department of Otorhinolaryngology, University of California San Francisco, San Francisco, California, - - 2014
The authors present a case of aggressive idiopathic orbital inflammation producing necrotizing scleritis along with synchronous tumefactive fibroinflammatory lesion of the temporal bone. A young woman with no medical history presented with sectoral scleritis and mildly reduced vision. Response to initial treatment, which included topical and systemic corticosteroids, as well ...
Maues De Paula André A Service d'Anatomie Pathologique, Hôpital la Timone, UMR911 AMU, Marseille, France, - - 2014
Some primary malignant or benign tumours of bone contain numerous multinucleated cells. These "giant cell-rich tumours of bone" have overlapping features and clinical and radiological data are needed to reach an accurate pathological diagnosis. We studied the potential contribution of p63 immunohistochemistry to the reliability of the histological diagnosis. We ...
Eismann Emily A EA Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, - - 2014
Synopsis Osteochondritis dissecans (OCD) is a disorder resulting in focal breakdown of the subchondral bone with potential disruption of the overlying articular cartilage. The femoral condyles of the knee are the most common locations for OCD, and the incidence of OCD appears to be increasing among active children. Juvenile OCD ...
Savage-Elliott Ian I Foot and Ankle Service, Hospital for Special Surgery, New York, New - - 2014
Osteochondral lesions of the talar dome are increasingly diagnosed and are a difficult pathology to treat. Conservative treatment yields best results in pediatric patients, often leaving surgical options for adult populations. There is a paucity of long-term data and comparisons of treatment options. Arthroscopic bone marrow stimulation is a common ...
Huang Hua H 1 Department of Radiology, 2 Department of Pathology, 3 Department of Hepatology, Shenzhen Third People's Hospital, Shenzhen 518112, - - 2014
Hepatic angiosarcoma, also called Kupffer's sarcoma, is a malignant mesenchymal neoplasm of endothelial cells, represents less than two percent of all primary liver neoplasm. Hepatic angiosarcoma is an infrequent and difficult-to-diagnose disease, mostly discovered by chance. Because of its rapid progression and usually fatal outcome, early diagnosis is necessary and ...
Estrada R J RJ Roberto Estrada, DVM, Equine Clinic, Free Universtiy of Berlin, Oertzenweg 19b, 14163 Berlin, Germany, Phone: +49 30 838 622 99, Fax: +49 30 838 625 29, E-mail: - - 2014
Objective: Even though equine multi-limb tendinopathy models have been reported, it is unknown if fore- and hindlimb tendon healing behave similarly. The aim of this study was to compare the healing process of surgically induced superficial digital flexor tendon (SDFT) core lesions of fore- and hindlimbs in horses. Methods: Tendon ...
Kieliszak Christopher R CR Ackerman Academy of Dermatopathology, New York, - - 2014
: Sports-related acquired connective tissue nevus or "athlete's nodule" has been reported under a variety of different names. The lesion develops in response to activity causing chronic or repetitive low-grade pressure or irritation activity, which is often a component of athletic training. A case of "athlete's nodule" in a figure ...
Hata H H Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, - - 2014
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe hereditary mechanobullous disease resulting from mutations in the COL7A1, gene coding for type VII collagen. RDEB patients tend to develop squamous cell carcinomas (SCC) at sites of chronic ulceration or scarring on the whole body. Distinguishing SCC from benign hyperkeratotic lesions is ...
Kim Tae Hyung TH *Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea; †Yeouido Oracle Cosmetic Dermatosurgery Clinic, Seoul, Korea; and ‡Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, - - 2014
Matrix metalloproteinase (MMP), tissue inhibitor of metalloproteinase (TIMP), and membrane-type 1 matrix metalloproteinase (MT1-MMP) are thought to be involved in the destruction of basement membrane and stromal invasion by cancer cells. The aim of this study was to identify and compare MMP and TIMP expression in internal malignancies and paired ...
Chen Wei W Departments of *Pathology †Gastroenterology, The Ohio State University Wexner Medical Center, Columbus, - - 2014
Core-needle biopsy remains essential for diagnosis of cirrhosis; however, evaluation of fibrosis in such biopsies is often challenging due to the fragmented nature of cirrhotic liver specimens. It is also common to see portions of liver capsules present in the biopsy which adds to the diagnostic challenge. The distinction between ...
Fremlin G A GA Department of Medicine, University Hospitals Bristol, Bristol, Avon, - - 2014
Pyoderma gangrenosum (PG) is a rare, non infectious, inflammatory disease characterized by neutrophilic infiltration of the dermis and destruction of tissue. PG is a diagnostic challenge which can lead to late diagnosis, delayed treatment and detrimental surgical interventions. Our case additionally describes a presentation not previously reported, affecting deep muscle ...
Lozano Martínez G A GA Servicio de diagnóstico por la imagen,Hospital de la Santa Creu i Sant Pau , Barcelona, España. Electronic address: - - 2014
Chondrosarcomas are malignant bone tumors originating in cartilage. Chondrosarcoma is the third most common malignant bone tumor after multiple myeloma and osteosarcoma. About 75% of chondrosarcomas are primary lesions. The remaining 25% belong to special categories such as histologic variants and secondary forms. A secondary chondrosarcoma is one that appears ...
Guzik Grzegorz G Department of Oncological Orthopaedics, Specialist Hospital in Brzozów - Podkarpacie Oncological Centre, - - 2014
Background. Primary bone lymphomas are very rare. The diagnosis is based on a histopathological examination and imaging studies where other disease foci should be excluded. The lymphomas are most often found in the axial skeleton, pelvis, femur and humerus. The tumour causes extensive lytic bone destruction with soft tissue infiltration. ...
Fu Xinge X Department of Pathology, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, - - 2014
Osteoblastoma is a benign bone-forming neoplasm that occurs commonly in the posterior elements of the spine and the sacrum. However, so far there has been no report of intradural osteoblastoma described in the literature. We present a unique case of intraspinal dural-based osteoblastoma with aneurysmal bone cyst-like change without evidence ...
Kim Joong Keun JK Department of Internal Medicine, Pusan National University College of Medicine, Busan, - - 2014
Malignant pheochromocytoma (PCC) is a rare condition. Although the liver is the second most frequent site of metastasis in malignant PCC, no definite treatments have been established. Herein, we report a case of liver metastasis of PCC that was successfully treated by transcatheter arterial chemoembolization (TACE). A 69-year-old man was ...
Northrup Benjamin E BE Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO. Electronic address: - - 2014
Many diseases result in polyostotic bone lesions including benign entities, benign entities with malignant potential, intermediate entities, and malignant entities. Imaging plays a key role in identifying complications of these disorders, most importantly malignant transformation of a benign lesion. The most common polyostotic bone lesions are reviewed and examples of ...
Sharma Leena L Northwestern University, Chicago, - - 2014
Little is known about early knee osteoarthritis (OA). The significance of lesions on magnetic resonance imaging (MRI) in older persons without radiographic OA is unclear. Our objectives were to determine the extent of tissue pathology by MRI and evaluate its significance by testing the following hypotheses: cartilage damage, bone marrow ...
Brandén Eva E Department of Respiratory Medicine, Gävle Hospital, Karolinska Institutet, Stockholm, Sweden ; Centre for Research and Development Uppsala University/County Council of Gävleborg, Sweden ; Karolinska Institutet, Stockholm, - - 2014
Core biopsies are valuable in obtaining sufficient tissue to ensure diagnosis of diseases in the thorax. To evaluate the complication rate and the diagnostic yield in computer tomography (CT)-guided core biopsies performed in a county hospital in Sweden. Medical journals, spirometry results, pathology reports and CT scans were reviewed in ...
Galeotti A A Department of Paediatric Surgery, Dentistry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, - - 2014
Ligneous periodontitis or gingivitis is a rare periodontal disorder, secondary to plasminogen deficiency, characterised by nodular gingival enlargements and progressive destructive membranous periodontal disease. We describe the early and successful dental management of a case of ligneous gingivitis secondary to plasminogen deficiency in a 6-year- old girl. The patient was ...
Batista Carolina Mayana de Avila CM SES, Regional Hospital of Asa Norte, Brasília, DF, - - 2014
Idiopathic Atrophoderma of Pasini and Pierini (IAPP) is a rare, exclusively cutaneous disease. It is more frequent in females, with incidence peak in the second and third decades of life. The etiopathogenesis remains unknown. IAPP most commonly affects the back, abdomen and proximal regions of the limbs. Lesions may be ...
Miranda Zambrano A David AD Virgen del Rocío Hospital, Seville, - - 2014
Elastofibroma is a benign fibroproliferative tumor of unknown origin and pathogenesis. It usually appears in the subscapular or infrascapular area. It is extremely rare in the spinal area, and it is most common in middle-aged women. In most cases, it is asymptomatic. Its diagnosis is based on nuclear MRI, where ...
El-Khalawany Mohamed M Department of Dermatology, Al-Azhar University, Cairo, Egypt. Electronic address: - - 2014
Prurigo is a common skin condition characterized by vigorous scratching. Although ulceration is not uncommon in prurigo, a perforating-like lesion was not previously reported. In this study we described series of cases of prurigo with perforating-like lesions and discussed its relation to acquired perforating dermatoses. The study included 32 cases, ...
Calhoun Benjamin C BC Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195. Electronic address: - - 2014
Apocrine adenosis (AA) and atypical apocrine adenosis (AAA) are uncommon findings in breast biopsies that may be misinterpreted as carcinoma. The data from long-term follow up studies of open biopsies suggest that AAA is not a high-risk or precursor lesion. The clinical significance and risk implications of AAA diagnosed on ...
Badial Peres R PR Department of Veterinary Clinical Science, School of Veterinary Medicine and Animal Science, UNESP - Univ Estadual Paulista, Botucatu, São Paulo, - - 2014
Hereditary equine regional dermal asthenia (HERDA) is an autosomal recessive disorder affecting quarter horses (QHs); affected horses exhibit characteristic skin abnormalities related to abnormal collagen biosynthesis. To characterize the thickness and morphological abnormalities of the skin of HERDA-affected horses and to determine the interobserver agreement and the diagnostic accuracy of ...
Palmieri C C School of Veterinary Science, The University of Queensland, QLD, - - 2014
Cutaneous mucinosis is a cutaneous disorder described in humans, dogs, and rarely cats but never reported in birds. Twenty-six brown egg-laying chickens between ages 43 and 46 weeks had a history of feather loss, scaly, dry skin, weight loss, and decreased egg production. Microscopic findings in the skin included fragmentation ...
Huang Yun-Chen YC Department of Otolaryngology, Head and Neck Surgery, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, Taipei, - - 2014
Giant cell tumour (GCT) in the parotid region is a rare lesion whose origin can be divided into three compartments: giant cell tumour of the salivary gland (GCT-SG), giant cell tumour of the bone (GCT-bone) and giant cell tumour of the soft tissue (GCT-ST). A low risk of malignancy has ...
Bianchi Francesca Antonella FA Department of Surgical Sciences (Head: Prof. G. Ramieri), Maxillofacial Surgery Section, San Giovanni Battista Hospital, University of Turin, Corso A.M. Dogliotti 14, Turin 10126, Italy. Electronic address: - - 2014
A 31-year-old woman presented with a large oro-nasal communication (ONC), loss of vomer and significant nasal cartilage and nose deformity. Physical examination of the patient revealed a typical midline destructive lesion (MDL) with nasal septum and hard/soft palate perforation with a friable granular surface and a large amount of necrotic ...
Chiba Ko K Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA; Department of Orthopedic Surgery, Nagasaki University School of Medicine, Nagasaki, Japan. Electronic address: - - 2014
Subchondral cysts are deeply related to the pathogenesis of osteoarthritis (OA), but the factors contributing to cyst formation are not well known. A three-dimensional analysis of subchondral cysts at the micro-structural level was conducted using a high-resolution peripheral quantitative CT (HR-pQCT), and their relationships with cartilage attrition and subchondral bone ...
Erickson Benjamin P BP Bascom Palmer Eye Institute , Miami, Florida , USA - - 2014
Abstract A 61-year-old man presented with a 2.5 cm fungating skin lesion above the right medial canthus, accompanied by fluctuance and subtle inferotemporal globe displacement. The tumor had erupted 2 months previously and grown rapidly. Computed tomography (CT) revealed a 4.2 × 2.8 × 2.1 cm exophytic mass of the right orbit, superimposed on chronic dacryocystitis. ...
Kontogeorgakos Vasileios A VA Department of Orthopaedic Surgery and Musculoskeletal Trauma, University Hospital of Thessaly, Larissa, - - 2014
Langerhans cell histiocytosis is a rare neoplastic proliferative disorder of the Langerhans cells. The clinical course is variable, ranging from a low symptomatic single bone lesion to fatal multiple organ involvement. Rarely, the sternum can be the first and single location of the disease. We report on a 12-year-old boy ...
Hwang Ki-Eun KE Department of Internal Medicine, Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, - - 2014
Malignant fibrous histiocytoma (MFH), a type of sarcoma, is a malignant neoplasm with uncertain origins that arise from both the soft tissues and the bone. The occurrence of MFH on the chest wall is extremely rare. We hereby report a case of a 72-year-old woman who was incidentally detected with ...
Kulkarni Rasika R RR Post Graduate Student, Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences , Manipal University, Mangalore, India - - 2014
Fibro-osseous lesions, along with few reactive lesions of the jaws exhibit an overlapping histo-morphologic spectrum with respect to the nature of calcifications and stromal components. This causes difficulty in assessing the origin, pathogenesis and diagnosis of these lesions. The present study analyses the mineralized components, cellularity, stromal density and stromal ...
Sousa Natália Guimarães Kalatzis NG Department of Restorative Dentistry, Araraquara Dental School, UNESP-Univ. Estadual Paulista, Rua Humaitá, 1680, 14801-903 Araraquara, SP, - - 2014
To evaluate the expression of matrix metalloproteinase inducer (EMMPRIN) and its correlation with the expression of matrix metalloproteinases (MMPs)-1, -2 and -9 during the development of periapical lesion in mice. Periapical lesions were induced in the lower first molars of mice and after 7, 14, 21 and 42 days the ...
Simon Maciej Jk - - 2014
The aim of this large collective and meticulous study of primary bone tumours and tumourous lesions of the hand was to enhance the knowledge about findings of traumatological radiographs and improve differential diagnosis. This retrospective study reviewed data collected from 1976 until 2006 in our Bone Tumour Registry. The following ...
Piposar Jonathan J Department of Orthopaedics & Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, - - 2014
We report on the arthroscopic treatment of a 12-year-old boy diagnosed with an osteochondral defect of the medial femoral condyle. He underwent arthroscopic fixation of the defect, and during the surgery, a blunt trocar was used to localize the lesion. The trocar created a transient dimpling effect on the cartilage ...
Rice Brittany B Fourth Year Podiatry Student, Samuel Merritt University California School of Podiatric Medicine, Oakland, - - 2014
Metastases to the bones in the foot are extremely uncommon, occurring in approximately 0.01% of all metastatic bone disease. We describe a case of an 82-year-old female with a metastatic pulmonary sarcomatoid carcinoma lesion to the midfoot. This rare and aggressive pulmonary malignancy has a poor prognosis. The purpose of ...
Ali Mohammad Javed MJ *Dacryology Service and †Ocular Pathology Service, L.V. Prasad Eye Institute, Hyderabad, Andhra Pradesh, - - 2014
Myxomas are rare benign tumors of primitive mesenchymal origin that usually arise from the soft tissues and occasionally from the bones. Bony myxomas predominantly arise from the jaw bone and hence are also known as gnathic myxomas. Any other bony myxomas are termed as extragnathic. In view of rarity, uncertain ...
Markhardt B Keegan BK Department of Radiology, Community Division, University of Wisconsin, Madison, WI. Electronic address: - - 2014
Discussion of articular cartilage disease detection by MRI usually focuses on the presence of bright signal on T2-weighted sequences, such as in Grade 1 chondromalacia and cartilage fissures containing fluid. Less emphasis has been placed on how cartilage disease may be manifested by dark signal on T2-weighted sequences. The appearance ...
Ji Jong-Hun JH Department of Orthopedic Surgery, College of Medicine, Daejeon St. Mary's Hospital, The Catholic University of Korea, 520-2, Daehung-dong, Jung-gu, Daejeon, 302-803, South - - 2014
Synovial chondromatosis is classified as either primary or secondary. Primary synovial chondromatosis results from a proliferation of chondrocytes in the synovial membrane leading to the formation of cartilaginous loose bodies. Secondary synovial chondromatosis is a rare condition characterized by the growth of separated particles from the articular cartilage or osteophytes ...
Roghi Marco M Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Largo Rosanna Benzi 10, Pad IV, 16132, Genova, Italy. - - 2014
Periapical cemento-osseous dysplasia (PCOD) is a rare benign lesion, often asymptomatic, in which fibrous tissue replaces the normal bone tissue, with metaplasic bone and neo-formed cement. We present a rare case of mandibular PCOD in a woman of 55 years, who presented with moderate swelling and mobility of teeth 32-33-34. ...
Tanaka Tetsuhiro T Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, - - 2014
Chloride secretion driven by calcium-dependent chloride channels has a major impact on cyst enlargement in polycystic kidney disease. Buchholz et al. studied the functional role of anoctamin 1 (ANO1), a recently identified calcium-activated chloride channel, in kidney cyst growth, using principal-like cells forming cysts within a collagen matrix and an ...
Pizzichetta Maria A MA *Division of Medical Oncology C, Preventive Oncology, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy; †Division of Pathology, Centro di Riferimento Oncologico, National Cancer institute, Aviano, Italy; ‡Dermatology Research Centre, the University of Queensland, School of Medicine, Translational Research Institute, Princess Alexandra Hospital, Brisbane, Australia; §Department of Dermatology, University of Siena, Siena, Italy; and ¶Department of Dermatology, Medical University of Graz, Graz, - - 2014
: It has been suggested that both negative pigment network (NPN) and shiny white streaks (SWS) were related to an increase of dermal collagen. To study precisely the dermoscopic-histopathologic correlation of NPN and SWS, we have performed a dermoscopic-pathological correlation study. A total of 25 skin lesions dermoscopically characterized by ...
Gregory James R - - 2014
Chondroblastoma is a rare, benign primary bone tumor that usually occurs at the epiphysis of long bones. The authors present an example of the diagnosis and successful treatment of this neoplasm in an exceedingly rare location in the distal phalanx. Clinical and radiographic outcomes after 68 months of follow-up are ...
Sathyanarayana B D BD Departments of Dermatology, Venereology and Leprosy, Adichunchanagiri Institute of Medical Sciences, BG Nagara, Bellur, Karnataka, - - 2014
Giant congenital nevomelanocytic nevus (GCNN) is a rare variant of congenital melanocytic nevus measuring >20 cm in size that often has a garment-like distribution. Regular follow up is recommended because of a risk of melanoma transformation of 4.6%. We report a 14-year-old boy with gradual regression of giant congenital melanocytic ...
Kundu Zile Singh ZS Department of Orthopaedics, Pt B D Sharma PGIMS, Rohtak, Haryana, - - 2014
Osteosarcoma is the most common primary osseous malignancy excluding malignant neoplasms of marrow origin (myeloma, lymphoma and leukemia) and accounts for approximately 20% of bone cancers. It predominantly affects patients younger than 20 years and mainly occurs in the long bones of the extremities, the most common being the metaphyseal ...
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