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Kim Ga Young GY Departments of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, - - 2014
Neuroendocrine lesions of the thyroid are rare. The most common types are medullary thyroid carcinomas (MTCs) and C-cell hyperplasia. MTCs originate from thyroid parafollicular cells that secrete calcitonin which serves as a serum marker of MTCs. Here, the rare case of a calcitonin-negative neuroendocrine tumor (NET) derived from follicular lesions ...
Chng Chiaw-Ling CL Department of Endocrinology, Level 3 The Academia, 20 College Road, Singapore, 169856; Department of Endocrinology, Royal Free Hospital, Pond Street, London, NW3 - - 2014
The cytological diagnosis of follicular neoplasm (Thy3F) remains a diagnostic challenge. The main aim of this study is to stratify the risk of malignancy in thyroid nodules diagnosed as Thy3F on cytology (Thy3F) using Thyroid Imaging Reporting and Data System (TIRADS). A database of thyroid nodules with Thy3F cytological results ...
Bina Saiid S 1Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, MD. 2Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, - - 2014
Malignant hyperthermia is a pharmacogenetic disorder typically triggered by potent inhalation anesthetics and/or the depolarizing muscle relaxant succinylcholine in malignant hyperthermia-susceptible individuals. Since lymphocytes express the same Ca channel mutation found in malignant hyperthermia-susceptible muscle, we investigated agonist-induced adenosine formation in lymphocytes as an index of sarcoplasmic reticulum Ca-release-induced adenosine ...
Ben Ari Ziv Z Ziv Ben Ari, Oranit Cohen-Ezra, Tania Bradichevsky, Ella Weitzman, Liver Disease Center, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, 52621 Tel Aviv, - - 2014
A ciliated hepatic foregut cyst (CHFC) is a rare foregut developmental malformation usually diagnosed in adulthood. Five percent of reported cases of CHFC transform into squamous cell carcinoma. We report the presentation, evaluation, and surgical management of a symptomatic 45-year-old male found to have a 6.2 cm CHFC. Contrast tomography-guided ...
Han Ruijun R Department of Ultrasound, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No.1630 Dongfang Road, Shanghai 200127, China. Electronic address: - - 2014
This study aimed at detecting whether Virtual Touch Tissue Quantification (VTQ) could be applied to differentiate between benign and malignant thyroid nodules with chronic autoimmune Hashimoto's thyroiditis (HT). Convenient ultrasound and Virtual Touch Tissue Quantification were performed in 118 patients with 140 thyroid nodules with histology results. The HT group ...
Tatar Idil Gunes IG Department of Radiology, Ankara Diskapı Training and Research Hospital, Ankara, - - 2014
Ultrasound is as a noninvasive method commonly used in the work-up of thyroid nodules. This study aimed to evaluate the usefulness of sonographic and elastosonographic parameters in the discrimination of malignancy. 150 thyroid nodules were evaluated by gray-scale, Doppler and elastosonography. The cytological analysis revealed that 141 nodules were benign ...
Wilmars Maud Mertens de - - 2014
Background: Solitary extramedullary plasmacytoma (SEP) is a rare malignant neoplasm arising from plasma cells. SEP mostly occurs in the upper respiratory tract. Thyroid gland is rarely affected (<78 cases). Methods/results: We describe the case of a 78-year-old woman presenting a rapidly enlarging palpable thyroid mass. Neck computed tomography scan showed ...
Guan Mingxu - - 2014
Thyroid malignant neoplasm develops from follicular or parafollicular thyroid cells. A higher proportion of anaplastic thyroid cancer has an adverse prognosis. New drugs are being used in clinical treatment. However, for advanced thyroid malignant neoplasm such as anaplastic thyroid carcinoma, the major impediment to successful control of the disease is ...
Handra-Luca A A Service d'Anatomie Pathologique, APHP GHU Avicenne, Bobigny, France; Universite Paris Nord Sorbonne Cite, Bobigny, France. - - 2014
Thyroid benign lymphoepithelial lesions are rare in adults, reported as associated with thyroiditis or adjacent to tumours. Here we report a unique case of a thyroid solid nodule with benign lymphoepithelial morphology. A 56-year-old woman presented with a thyroid nodule increasing in size. Thyroid function was normal. On the surgical ...
Wu Qiang Q Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. - - 2015
Malignant pleural effusion (MPE) is one of the most common pleura-associated conditions observed in clinical practice. The development of MPE usually defines advanced cancer with a poor prognosis. Carbohydrate antigen 15-3 (CA 15-3), as an effective pleural fluid biomarker, has been an object of ongoing research in the detection of ...
Park Ha Kyoung HK Department of General Surgery, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea, - - 2014
We here report on two cases of suspicious cytological findings upon ultrasound (US)-guided fine-needle aspiration (US-FNA) in patients with subacute thyroiditis (SAT). A 46-year-old woman who underwent US-FNA for a suspicious thyroid nodule in the right lobe at a local clinic was referred to our hospital for surgical treatment. Based ...
Yu Dongmei D Department of Special Examinations, Qingdao Women and Children Hospital, Qingdao, China - - 2014
Contrast-enhanced ultrasound (CEUS) is a new noninvasive modality for the diagnosis of thyroid nodules. However, the performance of CEUS in differentiating malignant and benign thyroid nodules has not been systematically evaluated. This meta-analysis was performed to assess the accuracy of CEUS in diagnosing thyroid nodules. PubMed, Embase, and the references ...
Nagashio Yoshikuni Y Department of Gasroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, - - 2014
Despite advances in imaging techniques, diagnosis and management of pancreatic cystic lesions still remains challenging. The objective of this study was to determine the utility of cyst fluid analysis (CEA, CA 19-9, CA 125, amylase, and cytology) in categorizing pancreatic cystic lesions, and in differentiating malignant from benign cystic lesions. ...
Liu Baoxian B Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, - - 2014
To evaluate the diagnostic performance of two-dimensional shear wave elastography (2D-SWE) in distinguishing malignant from benign thyroid nodules. A total of 331 focal thyroid nodules from 271 patients scheduled for fine-needle aspiration or thyroid surgery were included. After a routine conventional ultrasound evaluation, 2D-SWE examinations were performed to obtain 2D-SWE ...
Pérez-Sayáns M M Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Institute of Sanitary Research of Santiago , Entrerrios s/n, Santiago de Compostela C.P. 15782 , - - 2014
The presence and degree of dysplasia are important diagnostic and prognostic criteria for oral leukoplakia, but evaluation of dysplasia is difficult and subjective. Carbonic anhydrase-IX (CA-IX) is expressed primarily in tumor cells and is considered a specific hypoxia marker. We investigated the role of CA-IX in oral leukoplakia. We investigated ...
Kim Baek-Hui BH Korea University Guro Hospital, - - 2014
A 44-year-old man submitted for enlarged thyroid gland. Fine needle aspiration cytology showed bizarre hyperchromatic nuclei and medullary carcinoma was suspected. Thyroidectomy was done and frozen slides revealed hyperplastic thyroid follicles with bizarre nuclei with perithyroidal extension. The frozen diagnosis was malignant neoplasm with extrathyroidal extension. But, permanent sections of ...
Bhutia Chumila Thinley CT Assistant Professor, Department of Pathology, Sikkim Manipal Institute of Medical Sciences , Gangtok, Sikkim, India - - 2014
Riedel's thyroiditis (RT) is a rare fibrosclerotic infiltrative thyroid disorder of unclear aetiology. It has been reported in 0.06% of thyroid surgeries and is more common in women. A 60-year-old euthyroid male presented with thyroid swelling and sinus discharge since three years, associated with pain and fever. Near total thyroidectomy ...
Bhartiya Sk S Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, - - 2014
Thyroid hemiagenesis is a rare form of thyroid dysgenesis characterized by an absence of half of the thyroid gland. Developmental hemi-thyroid anomalies can result from either an abnormal descent or an agenesis of one lobe of the thyroid gland. We report a case of a 40-year-old woman with history of ...
Wei Xi X Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin, - - 2014
Background: The meta-analysis was preformed to review the diagnostic accuracy of ultrasound reporting and data system in the diagnosis of thyroid nodules. Methods: We identified the diagnostic accuracy of ultrasound reporting and data system in five databases. Meta-analyses were used in selected studies to obtain pooled sensitivity, specificity, and summary ...
Stokowy Tomasz T Institute of Automatic Control, Silesian University of Technology, ul.Akademicka 16, 44-100 Gliwice, Poland, and; Department of Nuclear Medicine and Endocrine Oncology, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch Wybrzeze AK 15, 44-101 Gliwice, Poland; Department of Clinical Science, University of Bergen, Postboks 7800, NO-5020 Bergen, - - 2014
The inherent diagnostic limitations of thyroid fine needle aspiration (FNA), especially in the "indeterminate" category, can be partially overcome by molecular analyses. We aimed at the identification of miRNAs that could be used to improve the discrimination of indeterminate FNAs. miRNA expression profiling was performed for 17 follicular carcinomas (FTCs) ...
Chen Kuen-Yuan KY Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Surgery, National Taiwan University Hospital, Taipei, - - 2014
To test whether computerized quantification of ultrasonic heterogeneity can be of help in the diagnosis of thyroid malignancy, we evaluated ultrasonic heterogeneity with an objective and quantitative computerized method in a prospective setting. A total of 400 nodules including 271 benign thyroid nodules and 129 malignant thyroid nodules were evaluated. ...
Pozo Eduardo E The Zena and Michael A. Wiener Cardiovascular Institute/Marie-Josee and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine, New York, NY, - - 2014
The noninvasive diagnosis of cardiac amyloidosis (CA) is often challenging. ECG abnormalities are common but lack both sensitivity and specificity. While some features on transthoracic echocardiography have confirmed the classical picture of CA, they have generally been validated against endomyocardial biopsy and thus are indicative of advanced disease. The ability ...
Dinc Bulent B Department of Surgery, Ataturk State Hospital, Antalya, - - 2014
Simple cysts (SCs) of the liver are not associated with the biliary malformations in intrahepatic bile duct biliary. Seen in 0.1% to 7% of adult population, biliary malformations are more common in women. The levels of glycoprotein-like tumor markers (carbohydrate antigen (CA) 19-9) in the cysts and serum could be ...
Agretti P P Department of Clinical and Experimental Medicine, Section of Endocrinology, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, - - 2014
Fine-needle aspiration (FNA) with cytologic evaluation is the most reliable tool for malignancy prediction in thyroid nodules, but cytologic diagnosis remains indeterminate for 12-18 % of nodules. BRAF V600E mutation has been reported to show a high specificity for malignant thyroid nodules and the use of this marker to refine indeterminate ...
Spârchez Zeno Z 3rd Medical Department,"O.Fodor" Institute for Gastroenterology and Hepatology,"Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. - - 2014
Hepatic cysts have a prevalence of 2.5-7% and most of them are asymptomatic. However, large cysts may cause complaints; in such cases an appropriate treatment is necessary (open surgery, laparoscopic deroofing, removal of cystic fluid and injection of a sclerosing agent. The aim of this study was to assess the ...
Gao Bingxia B Department of Gerontology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. - - 2014
The present study aimed to investigate polypoid colonic metastases from gastric stump carcinoma by performing a retrospective analysis of the clinical data of a patient with such a diagnosis, and by discussing other previous case studies from the literature. The patient of the present study was an 80-year-old male who ...
Soma Pier Francesco PF Healthcare Burns Unit, Cannizzaro Hospital, Catania 95126, - - 2014
Primary oral malignant melanoma is a rare condition, accounting for 1.3-1.4% of all melanomas, usually presenting with an aggressive clinical behavior. The present study reports the clinicopathological findings of two cases of oral malignant melanoma and discusses the epidemiology, diagnosis and current therapeutic approaches for this uncommon condition. In the ...
O Wong Ching-Yee CY aDepartment Diagnostic Radiology and Molecular Imaging, Oakland University William Beaumont School of Medicine, Royal Oak bCranbrook Educational Community, Bloomfield Hills, Michigan cUniversity of Tennessee, Knoxville, Tennessee, - - 2014
The aim of the study was to evaluate pulmonary nodules (PNs) by incorporating time sensitivity (S) factor in the retention index (RI) and compare with the traditional fixed interval method. After obtaining approval from the Human Investigations Committee, 97 PNs from 81 patients (age=70±11) referred for dual-time fluorine-18 fluorodeoxyglucose PET ...
de Tristan Julie J Department of Otorhinolaryngology, Head and Neck Surgery, University of Erlangen-Nuremberg Medical School, Waldstrasse 1, 91054, Erlangen, Germany, - - 2014
The objective of the present study is to report on the clinical course and management of thyroglossal duct cysts. Retrospective review of all patients who underwent surgery for thyroglossal duct cysts between 2000 and 2013 at a tertiary referral center was carried out. The operations were performed using a modification ...
Satchi Khami K *Orbital Plastic and Lacrimal Clinic, Royal Victorian Eye and Ear Hospital; †Department of Anatomical Pathology, St Vincent's Hospital; ‡Centre for Eye Research Australia, Department of Ophthalmology, University of Melbourne; and §Centre for Eye Research Australia, Department of Surgery, University of Melbourne, Melbourne, - - 2014
Melanoma of the conjunctiva may occasionally involve the lacrimal drainage apparatus (LDA). This makes clinical management difficult. The authors describe 5 cases of conjunctival melanoma with LDA disease and make recommendations about its management. Retrospective review of case notes and histopathology reports. Five cases of LDA melanoma arising in patients ...
Val-Bernal Jose-Fernando JF Department of Anatomical Pathology, Marques de Valdecilla University Hospital, Medical Faculty, University of Cantabria and Idival, SANTANDER, - - 2014
Vernix caseosa peritonitis is a rare complication caused by inflammatory response to amniotic fluid spilled into the maternal peritoneal cavity. Most cases occur after cesarean section. We discuss herein two patients, aged 33 and 29 years, who presented with vernix caseosa peritonitis seven to nine days after a cesarean delivery. ...
Noh Tai Kyung TK Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, - - 2014
Melasma is triggered by various factors including ultraviolet radiation and estrogen; however, its pathogenesis is unclear. To investigate the inflammatory features of melasma lesions as triggers for this disorder, 197 women with melasma who attended Asan Medical Center and Kangskin Clinic, Seoul, from June 2011 to October 2011 completed a ...
Schwensen Jakob F JF Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, 2900, Hellerup, - - 2014
The diagnosis of combined allergic and irritant contact dermatitis is an accepted subdiagnosis for hand dermatitis, and it is often considered in a patient with contact dermatitis, a positive and relevant patch test result, and wet work exposure. We therefore hypothesize that it is arbitrary for wet work exposure to ...
Mehmood Shafqat S Department of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre Lahore, - - 2014
Endoscopic ultrasound-guided fine needle aspiration cytology (EUS-FNA) is considered to be a minimally invasive and safe technique, with low complication rates, for obtaining tissue samples from pancreatic lesions, and mediastinal and intra-abdominal nodes. We retrospectively reviewed the diagnostic accuracy of this method at a tertiary care hospital in Pakistan. The ...
Vanhaecke C C Jr Service de Dermatologie, AP- HP Hôpital Saint Louis, Paris, - - 2014
Keloids are benign fibro-proliferative skin lesions that very rarely occur on the soles. Because of their rarity, the diagnosis of plantar keloids can be difficult. We describe the clinical and histopathological characteristics of eight plantar keloids. All patients presenting with plantar keloids between 2005 and 2012 in our Dermatology unit ...
Radhakrishnan Jayant J Division of Pediatric Surgery, Department of Surgery, University of Illinois, Chicago, IL. Electronic address: - - 2014
Accessory hemi diaphragm (AHD) is an uncommon condition. Its clinical features, diagnosis and management have not been clearly defined. We reviewed the world literature and added a case of our own. There are 40 proven cases in the literature. The lesion occurs almost exclusively in the right hemithorax. Twenty seven ...
Ojha Sandeep S - - 2014
Amyloid goiter is a rare cause of thyroid enlargement which can be confused clinically as well as cytologically with both colloid goiter and neoplastic process of thyroid. A 30-year-old man, diagnosed with chronic kidney disease 5 months previously and currently on dialysis and awaiting renal transplant, was referred by clinicians ...
Karamifar H H Endocrinology and Metabolism Research center, Shiraz University of Medical Sciences, Shiraz,Iran - - - 2014
Skin manifestations, including scalded skin, desquamation, and chronic periorificial dermatitis, are rare clinical signs in the patients with methylmalonic acidemia. This condition may be due to enzyme deficiency or multi--nutrient deficiency because of nutritional restriction. Bullous skin lesion is very rare in these patients and consequently, this type of skin ...
Yasuda Chie C Advanced Technology Research Center, Fancl Research Institute, Totsuka, Yokohama, 244-0813, - - 2014
Different biomarkers are used to evaluate the severity of atopic dermatitis (AD); however, it remains difficult to determine the severity of localized skin lesions. MIF plays an essential role in the pathophysiology of skin inflammation. In order to establish whether the MIF level in the stratum corneum (SC) serves as ...
Ohtsuka Takao T Departments of Surgery and Oncology, Graduate School of Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan, - - 2014
Routine endoscopic retrograde pancreatography (ERP) for pancreatic juice cytology (PJC) during management of intraductal papillary mucinous neoplasm (IPMN) is not recommended in the international consensus guidelines 2012. The aim of the present study was to investigate the roles of PJC in relation to the new stratification of clinical findings in ...
Akbulut Sevtap S Department of Otolaryngology Head and Neck Surgery, Dr. Lutfi Kirdar Kartal Training and Research Hospital, Denizer cd. E-5 Cevizli Mevkii Kartal, Istanbul, Turkey, - - 2014
The aim of this study is to prospectively compare rigid videolaryngostroboscopy with microlaryngoscopy for the diagnosis of benign vocal cord lesions. Eighty-five adult patients with benign vocal cord lesions were evaluated with videolaryngostroboscopy and later underwent microlaryngoscopy. During microlaryngoscopy, systematic examination of the glottis was conducted, including careful inspection and ...
Lee So-Yeon SY Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, - - 2014
The purpose of this study was to investigate whether ultrasound (US) elastography is useful for the early diagnosis of plantar fasciitis. We retrospectively reviewed US elastography findings of 18 feet with a clinical history and physical examination highly suggestive of plantar fasciitis but with normal findings on conventional US imaging ...
Bacci Christian - - 2014
Objective: The dentist has a fundamental role in the early diagnosis of lesions of the oral cavity. The aim of this study was to establish the rate of erroneous clinical diagnoses and whether a clinical diagnosis is enough. The study was conducted to ascertain the overall accuracy of clinical diagnoses ...
Vernooij-van Langen A M M AM Department of Paediatrics, Hospital St Jansdal, P.O. Box 138, 3840 BA Harderwijk, The Netherlands. Electronic address: - - 2014
Early diagnosis through newborn screening (NBS) and early treatment of cystic fibrosis (CF) do lead to better prognosis. In the Netherlands, the median age for a clinical diagnosis is six months, and after newborn screening this is 30days. It is unknown if being diagnosed at the age of six months ...
Gambitta Pietro P Pietro Gambitta, Antonio Armellino, Edoardo Forti, Unità di Chirurgia Endoscopica ed Ecoendoscopia Ospedale Niguarda Ca' Granda, 20162 Milano, - - 2014
To investigate the impact of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in association with a multidisciplinary team evaluation for the detection of gastrointestinal malignancies. A cohort of 1019 patients with suspected malignant lesions adjacent to the gastrointestinal tract received EUS-FNA after a standardized multidisciplinary team evaluation (MTE) and were divided into ...
Kvistad Christopher Elnan CE From the Departments of Neurology (C.E.K., H.O., N.L., L.T., U.W.-A., H.N.) and Radiology (G.M.), Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway (C.E.K., L.T.); and Centre of Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway (H.N.). - - 2014
Diffusion-weighted imaging (DWI) is highly accurate in identifying and locating ischemic stroke injury. Few studies using DWI have investigated large subcortical infarctions (LSIs). We aimed to study clinical characteristics, cause, and outcome in patients with ischemic stroke with LSI diagnosed on DWI and compare these with those who had lacunar ...
Treetipsatit Jitsupa J Departments of *Pathology ‡Pediatrics, Stanford University School of Medicine, Stanford, CA †Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, - - 2014
Congenital enteropathies comprise a constellation of rare clinicopathologic diagnoses characterized by intractable watery diarrhea and failure to thrive in infants. These diagnoses include, but are not limited to, tufting enteropathy (TE), microvillous inclusion disease (MID), and enteroendocrine cell dysgenesis (EED). Commonly, the diagnosis is based on identification of their characteristic ...
Ho-Wo-Cheong Dennis D Faculty of Medicine, McGill University, Montreal, QC, - - 2014
To analyze the characteristics and the associated medical co-morbidities in children with synchronous airway lesions (SALs) found during rigid bronchoscopy. Retrospective case series and chart review of patients who were found to have more than one airway lesion after undergoing airway evaluation via rigid endoscopy at a tertiary care pediatric ...
Salvaggio Heather L HL Bassett Healthcare Network, Oneonta, New - - 2014
Hermansky-Pudlak syndrome (HPS) is a rare genodermatosis characterized by oculocutaneous albinism, platelet dysfunction, and in some patients, pulmonary fibrosis and granulomatous colitis. The granulomatous inflammation in the bowel of patients with HPS can be indistinguishable clinically and histologically from that of Crohn disease (CD); however, mucocutaneous granulomatous lesions have not ...
Aung Phyu P PP *Department of Dermatology, Section of Dermatopathology, Boston University School of Medicine, Boston, MA; †Reno Center for Medical Oncology, Winchester, MA; and ‡Dermatopathology Associates, Winchester, - - 2014
: The authors describe a patient with a lesion on the right forearm. Her past medical history was significant for ulcerative colitis (UC, status post-colectomy six months prior). Eleven months earlier, she was diagnosed with myelodysplastic syndrome (MDS), a finding confirmed by bone marrow biopsy showing refractory anemia with excess ...
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