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Zhu Ling Yin LY State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, - - 2014
The study aims to clarify the role of narrow band imaging (NBI) in the prediction of invasion depth and the formation of lesion appearance under NBI with immunohistochemical analysis. As a prospective single-center study, Sano's classification of capillary pattern (CP) was applied to differentiate early colorectal neoplasms under NBI observation. ...
Nishii Yuko Y Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka 545-8585, - - 2014
Minimal deviation adenocarcinoma (MDA), also known as adenoma malignum of the uterine cervix, accounts for only ~1% of uterine cervical adenocarcinomas. Adenoma malignum of the uterine cervix was initially described by Gusserow in 1870. Using magnetic resonance imaging (MRI), MDA appears as multilocular lesions with solid components that extend from ...
Malhi Harshawn H 1 Department of Radiology, Keck School of Medicine, University of Southern California, 1500 San Pablo St, Los Angeles, CA - - 2014
OBJECTIVE. This study was undertaken to define and evaluate echogenic foci and their posterior acoustic artifacts in thyroid nodules. Whether these findings were indicative of benignity or malignancy was assessed. MATERIALS AND METHODS. Echogenic foci were classified into five types: no posterior artifact, large comet-tail artifact, small comet-tail artifact (≤ ...
Badertscher Nina - - 2014
BackgroundThe rising incidence of melanoma ¿ Switzerland has the highest incidence in Europe - is a major public health challenge. Swiss dermatologist introduced the ¿Swiss Skin Cancer Day¿ (SSCD) in 2006, which provides skin cancer screening at no costs. The aim of the study was to describe the participating subjects ...
Schrading Simone S From the Department of Diagnostic and Interventional Radiology, University of Aachen, RWTH, Pauwelsstr 30, 52074 Aachen, - - 2014
Purpose To use digital breast tomosynthesis ( DBT digital breast tomosynthesis )-guided vacuum-assisted biopsy ( VAB vacuum-assisted biopsy ) to sample target lesions identified at full-field digital screening mammography and compare clinical performance with that of prone stereotactic ( PS prone stereotactic ) VAB vacuum-assisted biopsy . Materials and Methods ...
Chau Karen K Department of Cytopathology, North Shore-LIJ Health System, Lake Success, New - - 2014
At a high-volume center, it became necessary to provide benchmarks for the accuracy and risk of malignancy per urine cytology diagnostic category. The additive sensitivity for the determination of the residual risk of disease was calculated with the goal of determining the performance of cytology and optimal triage, including the ...
Kaltenbach Tonya T Veterans Affairs Palo Alto, GI Endoscopy Unit and Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California, - - 2014
Diminutive (≤5 mm) colorectal polyps are common, and overwhelmingly benign. Routinely, after polypectomy, they are examined pathologically to determine the surveillance intervals. Advances in equipment and techniques, such as narrow-band imaging (NBI) colonoscopy, now permit reliable real-time optical diagnosis. We conducted a randomised single-masked study involving three institutions to determine whether ...
Cohen J M JM Department of Dermatology, Brigham and Women's Hospital, Boston, MA, - - 2014
Cutaneous granulomatous eruptions comprise a rare subset of paraneoplastic dermatitides most commonly associated with haematologic malignancies. The pathogenesis of these eruptions remains poorly understood. Carcinoid tumours are uncommon neuroendocrine neoplasms that most often arise in the gastrointestinal tract and produce excess serotonin leading to diarrhoea and flushing. Metastases can result ...
Chen Clark C CC University of California, San Diego, San Diego, CA, - - 2014
Stereotactic biopsies are frequently performed to secure definitive diagnosis for brain tumor patients. Fundamentally, there are two major difficulties in these endeavors. First, because of intra-tumoral heterogeneity inherent in many forms of brain cancer, biopsies taken from one region may yield a different diagnosis than if another area is biopsied. ...
Xu Chaoli - - 2014
Automated breast volume scanner (ABVS) and US elastography (UE) have been useful for the differentiation of benign and malignant lesions. However, combining these two methods applied in diagnosis of breast lesions has not yet been reported. The aim of this study is to analyze the inter-examiner reliability of ABVS and ...
Kim Hakushi H Department of Urology, Tokai University Hachioji Hospital, Hachioji, Tokyo 192-0032, - - 2014
The present study reports a case of prostate adenocarcinoma with cyst formation. A 72-year-old male diagnosed with multiple lung metastases at a local clinic was referred to Tokai University Hachioji Hospital (Tokyo, Japan) for detection of a primary lesion. Whole body positron emission tomography/computed tomography showed strong accumulation of [(18)F]-fluoro-deoxy-2-glucose ...
Nakhlis Faina F Department of Surgery, Brigham and Womens Hospital, Boston, USA, - - 2014
Intraductal papillomas (IPs) are commonly seen breast lesions with variable clinical presentation. For a palpable lesion and/or evidence of cellular atypia and/or pathologic nipple discharge, excision is warranted to rule out adjacent carcinoma, while for asymptomatic IPs lacking atypia current data for excision vs. observation are controversial. We reviewed outcomes ...
Ide Fumio F Division of Oral Pathology, Department of Diagnostic and Therapeutic Sciences, MeikaiUniversity School of Dentistry, Saitama, - - 2014
We would like to express our views regarding the recently published article by Mosqueda-Taylor et al.on primordial odontogenic tumour (POT), which they considered to be a previously undescribed, benign ectomesenchymal neoplasm. We agree with the authors that all six of the lesions presented have many features of interest and importance with ...
Sigel Carlie S CS Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New - - 2014
Identifying high-grade features in patients with pancreatic mucinous neoplasms (MNs) is important for patient management. The reproducibility of MN cytology grading has been evaluated to a limited extent. In the current study, the authors evaluated interobserver variability in grading MNs and the identification of neoplastic mucin in endoscopic ultrasound-guided fine-needle ...
Uniyal Nishant - - 2014
This work reports the use of ultrasound radio frequency (RF) time series analysis as a method for ultrasoundbased classification of malignant breast lesions. The RF time series method is versatile and requires only a few seconds of raw ultrasound data with no need for additional instrumentation. Using the RF time ...
Qin Xiumin - - 2014
Endoscopic treatments for early esophageal squamous cell carcinoma and the esophageal neoplasm are two types: endoscopic resection (ER) and ablation. Resection enables evaluation of the lesion in the ER specimens, while ablation cannot. We sought to establish a pre-ER evaluated system with a diagnostic and staging accuracy similar to ER ...
Sakellariou Vasileios I VI 1st Department of Orthopaedic Surgery, ATTIKON University General Hospital, University of Athens, 1 Rimini Street, 12462, Chaidari, Greece, - - 2014
Multiple myeloma is a malignancy of monoclonal plasma cells (plasma cells are of B-lymphocyte lineage of the hematopoietic system). It is the second most prevalent blood malignancy after non-Hodgkin's lymphoma. It accounts for approximately 1 % of all malignancies and 2 % of all cancer deaths. Bony involvement is very common; the ...
Rodrigues Phamilla Gracielli Sousa PG Sao Carlos Institute of Physics, University of Sao Paulo (USP), Biophotonics Laboratory, Sao Carlos-SP, Brazil. - - 2014
Photodynamic therapy (PDT) is used for skin treatments of premalignant and cancer lesions and recognized as a non-invasive technique that combines tissue photosensitization and subsequent exposure to light to induce cell death. However, it is limited to the treatment of superficial lesions, mainly due to the low cream penetration. Therefore, ...
Wang Jayson J Department of Histopathology, Imperial College London, - - 2014
Mucins are a family of glycoproteins expressed by epithelial cells. They show specific tissue type expression, and are useful for differentiating between different cancers. Studies have shown changes in mucins expression with tumour progression in a variety of cancers. Here, we characerize the profile of mucins expression in benign, borderline ...
Timms John F JF EGA Institute for Women's Health, University College London, - - 2014
Ovarian cancer is a devastating disease and biomarkers for its early diagnosis are urgently required. Serum may be a valuable source of biomarkers which may be revealed by proteomic profiling. Herein, complementary serum protein profiling strategies were employed for discovery of biomarkers that could discriminate cases of malignant and benign ...
Shim Choong Nam CN Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Korea, - - 2014
Safety of endoscopic resection (ER) for early gastric cancers (EGC) with mixed histology predominantly of differentiated type has not been securely established, since those lesions tend to exhibit lymph node metastasis, compared to pure differentiated type. The purpose of this study was to evaluate clinicopathologic characteristics, therapeutic outcomes, and risk ...
Chang Jung Min JM Department of Radiology, Seoul National University Hospital, Seoul, Republic of - - 2014
Automated breast ultrasound (ABUS) is gaining popularity for breast cancer detection and diagnosis with its high reproducibility. Consistent recognition of breast lesions on serial exams is critical, and high reproducibility for lesion characterization is expected with ABUS, but not well reported. To retrospectively evaluate the reproducibility of ABUS for mass ...
Mascalchi Mario M From the *"Mario Serio" Department of Experimental and Clinical Biomedical Sciences, University of Florence; †Quantitative and Functional Radiology Research Program at Meyer Children and Careggi Hospitals of Florence, Florence; ‡Cardio-Thoracic Radiology, Cardio-Thoracic-Vascular Department, Sant'Orsola-Malpighi University-Hospital, Bologna; §Nuclear Medicine Unit, "Le Scotte" University Hospital, Siena; ∥Division of Pneumonology, Careggi Hospital, Florence; and ¶Nuclear Medicine Department, Sant'Orsola-Malpighi University-Hospital, Bologna, - - 2014
This study aimed to define computed tomographic morphologic features of lung cancer associated with cystic airspaces, their modifications in serial computed tomographic scans, and F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography uptake. Computed tomographic scans and F-FDG positron emission tomography in 24 patients with lung cancer (17 adenocarcinomas, 7 squamous cell carcinomas, ...
Collins Laura C LC 1Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA 2Faculdade de Medicina Universidade Federal de Minas Gerais Belo Horizonte, MG, Brazil 3South Australia Pathology, Adelaide, SA, - - 2014
The purpose of this course will be to provide pathologists with an update on breast core needle biopsy procedures using examples of such cases to address areas of recurrent diagnostic difficulty. The educational needs we will be targeting are primarily medical knowledge. We will select cases that constitute recurrent diagnostic ...
Kawai Toshiaki T 1National Defense Medical College 2Tokyo Womens Medical University Yachiyo Medical Center 3Yamaguchi Grand Medical Center 4Toda Central Medical Laboratory, - - 2014
Mesotheliomas produce body cavity effusion in about 70% of cases. Their cytologic diagnosis is hindered by the existence of a wide range of sensitivities, (according to the guidelines for pathologic diagnosis of malignant mesothelioma) and by the absence of a key histologic diagnostic feature, invasion of tumor cells into preexisting ...
Tanaka Shinya S Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, - - 2014
We have recently developed a new rapid IHC method (R-IHC) based on an alternating current (AC) electric field to facilitate the antigen-antibody reaction. By using this R-IHC method, reaction time of primary antibody can be almost 5 min. and entire procedure of IHC can be accomplished within 20 min. This R-IHC method ...
Lam Michael M Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore 308433, Republic of - - 2014
The most common type of intraocular tumor in adults is the metastatic variety, with the choroid as the typical site of involvement. The case of a patient with non-small cell lung cancer, who presented with choroidal metastasis, is described in the current report. In addition, the limitation of using a ...
Kauffmann Rondi M RM Department of General Oncologic Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010-3000, - - 2014
Melanoma continues to be one of the fastest growing cancers in terms of incidence. The workup of melanoma focuses on risk factors based on the visual aspects of a skin lesion. Risk factors including sun exposure increase the risk of melanoma. Staging is based on depth of invasion, mitotic rate, ...
Stubblefield Jonathan J School of Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, - - 2014
Melanoma is the most dangerous form of skin cancer and the sixth leading cause of malignancy in the United States. Non-Caucasians have a decreased overall incidence of melanoma, but African Americans and other ethnic groups often have more advanced disease at initial diagnosis and higher mortality rates than Caucasian populations. ...
Carillo Gerardo Andrés Obeso GA Department of Thoracic Surgery, Vigo University Clinical - - 2014
The effort to detect lung cancer in ever-earlier stages leads to the identification of an increasing number of patients without preoperative histological diagnosis. The aim of this study is to determine the prevalence and characteristics of benign lesions excised in the context of lung cancer surgery. We retrospectively analyzed data ...
Gardiner Natasha N 1 Specialty Registrar in Clinical Radiology, Wessex Deanery, UK ; 2 Consultant Histopathologist, University Hospital Southampton NHS Foundation Trust, UK ; 3 Consultant Radiologist, Portsmouth Hospitals NHS Trust, - - 2014
Advances in our understanding of the pathology, radiology and clinical behaviour of peripheral lung adenocarcinomas facilitated a more robust terminology and classification of these lesions. The International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification introduced new terminology to better reflect this heterogeneous group of ...
Zhang Hu H 1 Department of Thoracic Surgery, 2 Department of Anesthesiology, Sir Run Run Shaw Hospital Affiliated with Medical College of Zhejiang University, Hangzhou 310016, China ; 3 Department for Chronic and Noncommunicable Disease Control and Prevention, Hangzhou center for disease control and prevention, Hangzhou 310021, - - 2014
This study is designed to investigate the treatment approach and prognosis of pulmonary ground-glass-like shadow, especially solitary nodular ground-glass opacity (SNGGO). Forty-nine cases of SNGGO that persisted after anti-inflammatory treatment in our hospital were retrospectively studied. These patients received thoracoscopic surgery due to indefinitive diagnosis and a tendency of canceration ...
Goldenberg Gary G Icahn School of Medicine at Mount Sinai, Department of Dermatology, New York, New - - 2014
Actinic keratosis is widely considered a field disease that is rarely limited to a single clinically apparent lesion. Field-directed therapies, such as ingenol mebutate, imiquimod, and photodynamic therapy, aim to treat not only clinically visible lesions, but also subclinical disease that is thought to exist along the same continuum as ...
Gucer Hasan H Department of Pathology, Recep Tayyip Erdogan University, School of Medicine, Rize, - - 2014
Prostatic melanosis is a very rare, benign lesion characterized by the presence of melanin in the epithelium of the prostate gland and stromal dendritic cells, requiring no additional treatment. It constitutes the melanocytic lesions of the prostate together with blue nevus and malignant melanoma. We present a case with prostatic ...
Ali Amir M AM Department of Urology, Institute of Nephro Urology, Bangalore, Karnataka, - - 2014
Xanthogranulomatous cystitis (XC) is a rare benign disease of unknown etiology. A 39-year-old female presented with 2 month history of urgency, dysuria, lower abdominal mass. On physical examination a hard hypogastric mass was present fixed to the rectus muscle. Computerized tomography (CT) abdomen showed heterogeneous enhancing mass arising from the ...
Koc Kevser K Department of Nuclear Medicine, Marmara University School of Medicine, Istanbul, - - 2014
The information regarding fluorodeoxyglucose (FDG) uptake in benign and malignant cardiac tumors is limited in the literature and most of the currrently available data were derived from single case reports. Herein we reported coexistence of atrial myxoma and lung cancer on FDG positron emission tomography/computed tomography with the aim of ...
Wollina Uwe U Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, 01067 Dresden, - - 2014
Cutaneous mosaicism is a possible cause of segmental skin diseases. Cutaneous leiomyomatosis represent a spectrum of conditions ranging from single lesions to disseminated wide distribution. Reed's syndrome, is an autosomal dominant disorder characterized by multiple cutaneous and uterine leiomyomas. We observed a segmental cutaneous piloleimyomatosis type 1 in a 55-year ...
Suhani Department of General Surgery, Lady Hardinge Medical College, New Delhi, - - 2014
Epidermal, or inclusion, cysts are frequently seen benign lesions that are lined with stratified squamous epithelium. Malignant transformation of these is rare, occurring in 0.011% to 0.045% cases [1]. We herein report an unusual case of squamous cell carcinoma occurring in an epidermal cyst of the breast in a middle ...
Tan Jieying J Department of Medical Imaging, Guangzhou Nansha Central Hospital, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong Province, 510150, People's Republic of - - 2014
The aim of this study is to perform a meta-analysis to evaluate the diagnostic performance of the in vivo post-contrast proton magnetic resonance spectroscopy (MRS) for benign/malignant discrimination of focal breast lesions. Sixteen studies with a total of 661 malignant breast lesions and 388 benign breast lesions were included. The ...
Mazziotti Silvio S Department of Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy. Electronic address: - - 2014
Neoplasms of retromolar trigone have important peculiarities due to their spatial relationships with the surrounding structures. Tumours that involve this area can extend to nearby muscles; adipose spaces; and other anatomic structures, such as the soft palate, the tonsillar fossa, the parapharyngeal space, and the floor of the mouth. In ...
Iima Mami - - 2014
The purpose of this study was to explore the potential of non-Gaussian diffusion and perfusion magnetic resonance imaging (MRI) using intravoxel incoherent motion (IVIM) MRI for the diagnosis of breast lesions. This study included 26 women with breast lesions. Diffusion-weighted images were acquired using 16 b values up to 2500 ...
Bogosavljević Vojislav - - 2014
Objectives Comparison of redox conditions in malignant and benign tumours is essential for understanding the role of reactive oxygen species in the pathophysiology of aggressive cancer profiles. Here we compare antioxidative systems in highly malignant brain tumour - glioblastoma multiforme (GBM), and in meningioma, a benign brain tumour. Methods Tumour ...
Pereira A K C - - 2014
ABSTRACT Background The genesis of the endometrial polyp is as yet unclear. There is evidence that the polyp is related to the inflammatory process and that it interacts with the COX-2 enzyme. Objective To review the influence of COX-2 on the postmenopausal endometrial polyp. Methods Search Strategy: A systematic review ...
Ronot Maxime M Department of Radiology, APHP, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-Seine, France, - - 2014
To prospectively assess the stiffness of incidentally discovered focal liver lesions (FLL) with no history of chronic liver disease or extrahepatic cancer using shearwave elastography (SWE). Between June 2011 and May 2012, all FLL fortuitously discovered on ultrasound examination were prospectively included. For each lesion, stiffness was measured (kPa). Characterization ...
Hussain Alia Arif AA Department of Dermatology, Roskilde Hospital, University of Copenhagen, Køgevej 7-13, 4000, Roskilde, Denmark, - - 2014
Since its introduction in dermatology in the late 1990s optical coherence tomography (OCT) has been used to study many skin diseases, in particular non-melanoma skin cancer and it s precursors. Special attention has been paid to superficial basal cell carcinoma (BCC), and a number of smaller observational studies have been ...
Zhang Lei L Departments of *Pathology, Cytopathology Division †Pathology, Surgical Pathology Division, The University of Chicago, Chicago, - - 2014
Indeterminate thyroid nodules form a heterogenous group of lesions that constitute 5% to 30% of thyroid cytology diagnoses. We introduce a triple immunostaining protocol for subtyping. Galectin-3, HBME-1, and p27 triple immunostaining, performed on destained cytology slides and formalin-fixed paraffin-embedded tissue, was developed and applied to 51 patients retrospectively with ...
Martinez Victor D VD BC Cancer Research Centre, Department of Integrative Oncology, Vancouver, - - 2014
Worldwide, oral cancer is responsible for 170,000 deaths per year. Intervention to prevent this disease is a long sought after goal. Chemoprevention studies have focused on clinicopathological features of potentially malignant lesions (PML) in an effort to prevent their progression to cancer. However, prediction of future behavior for such lesions ...
Zografos G G Breast Unit, University of Athens School of Medicine, Athens, Greece, - - 2014
To demonstrate the use of a new 3D diagnostic imaging technology, termed Multimodal Ultrasonic Tomography (MUT), for the detection of solid breast lesions < 15 mm in maximum dimension. 3D MUT imaging was performed on 71 volunteers presenting BIRADS-4 nodules, asymmetrical densities, and architectural distortions in X-ray mammograms, who subsequently underwent biopsy. MUT ...
Bayanati Hamid H Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, The Ottawa Hospital Research Institute, 501 Smyth Road, Box 232, Ottawa, ON, Canada, K1H - - 2014
To assess the accuracy of CT texture and shape analysis in the differentiation of benign and malignant mediastinal nodes in lung cancer. Forty-three patients with biopsy-proven primary lung malignancy with pathological mediastinal nodal staging and unenhanced CT of the thorax were studied retrospectively. Grey-level co-occurrence and run-length matrix textural features, ...
Laine Mustapha - - 2014
Tracheobronchopathia osteochondroplastica (TO) is a rare disorder of unknown cause affecting the large airways. It is characterized by the accumulation of bony and cartilaginous nodules in the tracheal and bronchial mucosa.Approximately 300 cases of tracheobronchopathia osteochondroplastica have been reported since Wilks first identified it in 1857. Tomography and computed tomography ...
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