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Collins Laura C LC 1Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA 2Faculdade de Medicina Universidade Federal de Minas Gerais Belo Horizonte, MG, Brazil 3South Australia Pathology, Adelaide, SA, - - 2014
The purpose of this course will be to provide pathologists with an update on breast core needle biopsy procedures using examples of such cases to address areas of recurrent diagnostic difficulty. The educational needs we will be targeting are primarily medical knowledge. We will select cases that constitute recurrent diagnostic ...
Kawai Toshiaki T 1National Defense Medical College 2Tokyo Womens Medical University Yachiyo Medical Center 3Yamaguchi Grand Medical Center 4Toda Central Medical Laboratory, - - 2014
Mesotheliomas produce body cavity effusion in about 70% of cases. Their cytologic diagnosis is hindered by the existence of a wide range of sensitivities, (according to the guidelines for pathologic diagnosis of malignant mesothelioma) and by the absence of a key histologic diagnostic feature, invasion of tumor cells into preexisting ...
Tanaka Shinya S Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, - - 2014
We have recently developed a new rapid IHC method (R-IHC) based on an alternating current (AC) electric field to facilitate the antigen-antibody reaction. By using this R-IHC method, reaction time of primary antibody can be almost 5 min. and entire procedure of IHC can be accomplished within 20 min. This R-IHC method ...
Lam Michael M Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore 308433, Republic of - - 2014
The most common type of intraocular tumor in adults is the metastatic variety, with the choroid as the typical site of involvement. The case of a patient with non-small cell lung cancer, who presented with choroidal metastasis, is described in the current report. In addition, the limitation of using a ...
Ronot Maxime M Department of Radiology, APHP, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-Seine, France, - - 2014
To prospectively assess the stiffness of incidentally discovered focal liver lesions (FLL) with no history of chronic liver disease or extrahepatic cancer using shearwave elastography (SWE). Between June 2011 and May 2012, all FLL fortuitously discovered on ultrasound examination were prospectively included. For each lesion, stiffness was measured (kPa). Characterization ...
Hussain Alia Arif AA Department of Dermatology, Roskilde Hospital, University of Copenhagen, Køgevej 7-13, 4000, Roskilde, Denmark, - - 2014
Since its introduction in dermatology in the late 1990s optical coherence tomography (OCT) has been used to study many skin diseases, in particular non-melanoma skin cancer and it s precursors. Special attention has been paid to superficial basal cell carcinoma (BCC), and a number of smaller observational studies have been ...
Zhang Lei L Departments of *Pathology, Cytopathology Division †Pathology, Surgical Pathology Division, The University of Chicago, Chicago, - - 2014
Indeterminate thyroid nodules form a heterogenous group of lesions that constitute 5% to 30% of thyroid cytology diagnoses. We introduce a triple immunostaining protocol for subtyping. Galectin-3, HBME-1, and p27 triple immunostaining, performed on destained cytology slides and formalin-fixed paraffin-embedded tissue, was developed and applied to 51 patients retrospectively with ...
Zografos G G Breast Unit, University of Athens School of Medicine, Athens, Greece, - - 2014
To demonstrate the use of a new 3D diagnostic imaging technology, termed Multimodal Ultrasonic Tomography (MUT), for the detection of solid breast lesions < 15 mm in maximum dimension. 3D MUT imaging was performed on 71 volunteers presenting BIRADS-4 nodules, asymmetrical densities, and architectural distortions in X-ray mammograms, who subsequently underwent biopsy. MUT ...
Bayanati Hamid H Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, The Ottawa Hospital Research Institute, 501 Smyth Road, Box 232, Ottawa, ON, Canada, K1H - - 2014
To assess the accuracy of CT texture and shape analysis in the differentiation of benign and malignant mediastinal nodes in lung cancer. Forty-three patients with biopsy-proven primary lung malignancy with pathological mediastinal nodal staging and unenhanced CT of the thorax were studied retrospectively. Grey-level co-occurrence and run-length matrix textural features, ...
Laine Mustapha - - 2014
Tracheobronchopathia osteochondroplastica (TO) is a rare disorder of unknown cause affecting the large airways. It is characterized by the accumulation of bony and cartilaginous nodules in the tracheal and bronchial mucosa.Approximately 300 cases of tracheobronchopathia osteochondroplastica have been reported since Wilks first identified it in 1857. Tomography and computed tomography ...
Choi Seon Hyeong SH Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Radiology, School of Medicine, Graduate School, Hanyang University, Seoul, Korea. Electronic address: - - 2014
Papillary neoplasms of the breast comprise a broad range of pathologies ranging from papillomas to papillary carcinomas and have been associated with breast cancers. In this study, we evaluated the clinical, mammographic and sonographic features of papillary breast neoplasms from benign papillary breast lesions to malignancy-associated papillary lesions. A total ...
Gleason Joseph M JM Division of Urology, The Hospital for Sick Children, Department of Surgery, The University of Toronto, Toronto, ON, Canada; Division of Pediatric Urology, LeBonheur Children's Hospital, Department of Urology, The University of Tennessee, Memphis, TN, USA. Electronic address: - - 2014
To examine the presentation, diagnosis and management of radiologically diagnosed pediatric urachal anomalies and assess the risk of malignant degeneration. Our radiology database (2000-2012) was queried for all children under the age of 18 who were diagnosed with a urachal anomaly radiographically, and the operative database was utilized to determine ...
Mathur Aarti A Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, - - 2014
The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) describes several subcategories within atypia of undetermined significance (AUS), including (1) presence of focal nuclear atypia (AUS-N), (2) focal microfollicular proliferation (AUS-F), (3) focal Hürthle cell proliferation (AUS-HC), and (4) other (AUS-O). Several publications suggest that 5-15% is an underestimate of the ...
Chen Limin L Department of Ultrasound Diagnosis, Wenzhou Central Hospital, Jiangbin West Rd, Wenzhou, 325000, China, - - 2014
To examine the performance of shear-wave elastography (SWE) for the differentiation of benign and malignant breast lesions using a meta-analysis. PubMed, Embase and the Cochrane library were searched for studies published up to January 2014. The references of retrieved relevant articles were reviewed to identify potential publications. Random-effect meta-analysis was ...
Bradley Maria M Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Dermatology and Venereology, Karolinska University Hospital, Stockholm, - - 2014
The rare autosomal dominant condition Birt-Hogg-Dubé syndrome (BHD) is attributed to mutations on chromosome 17 in the folliculin (FLCN) gene, but not always diagnosed due to lack of, or a variety of symptoms such as fibrofolliculomas, lung cystic lesions, spontaneous pneumothorax and renal cancer. We hypothesized that the lack of ...
Zhou JianQiao J Department of Ultrasound, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200025, - - 2014
To compare the diagnostic performance of the fat-to-lesion strain ratio (FLR) and gland-to-lesion strain ratio (GLR) in the diagnosis of breast lesions. This was an institutional ethics committee approved prospective study. One hundred and ninety-three breast lesions in 193 women (mean age, 46.03 ± 13.60 years, range 18-82 years) were examined with conventional and ...
Mehta Hiren J HJ Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, - - 2014
Endobronchial ultrasound-guided transbronchial fine-needle aspiration (EBUS-FNA) has gained acceptance as the diagnostic procedure of choice with which to sample hilar and mediastinal lymph nodes (LNs) for diagnosing and staging patients with lung cancer. Studies have shown that EBUS has a high positive predictive value; however, its negative predictive value (NPV) ...
Belum Viswanath Reddy VR Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New - - 2014
The use of BRAF inhibitors may lead to the development of cutaneous toxicities such as rashes, photosensitivity, alopecia, palmoplantar erythrodysesthesia, and proliferative skin lesions, including keratoacanthomas (KAs) and cutaneous squamous cell carcinomas (cuSCCs). The latter are noteworthy for their potential to exhibit malignant features, and they may necessitate invasive treatment. ...
Lourenco Ana P AP 1 Department of Diagnostic Imaging, Alpert Medical School of Brown University, Rhode Island Hospital, Main Bldg, 3rd Fl, 593 Eddy St, Providence, RI - - 2014
OBJECTIVE. The purpose of this article is to determine the underestimation rate of high-risk lesions diagnosed at MRI-guided breast biopsy. MATERIALS AND METHODS. This was a retrospective review of 446 MRI-guided breast biopsies from January 2006 through December 2010. Data were collected on examination indication, lesion size and type, and ...
Kuzmiak Cherie M CM Department of Radiology, University of North Carolina Lineberger Comprehensive Cancer Center (C.M.K.), Department of Medicine, Center for Gastro intestinal Biology and Disease (M.Q.L.), and Department of Biostatistics (D.Z., X.L.), University of North Carolina, Chapel Hill, North Carolina USA. - - 2014
The purpose of this retrospective study was to assess the sonographic features of benign, high-risk, and malignant papillary lesions of the breast. We conducted a search of our institution's breast biopsy database for all papillary lesions with sonographic findings and final surgical pathologic diagnoses from January 1, 2004, to December ...
Tagliafico Alberto A Institute of Anatomy, Department of Experimental Medicine (DIMES), University of Genoa, Largo Rosanna Benzi 8, 16132, Genoa, Italy, - - 2014
To compare DBT and FFDM in the classification of microcalcification clusters (MCs) using BI-RADS. This Institutional Review Board-approved study was undertaken in three centres. A total of 107 MCs evaluated with both DBT and FFDM were randomised for prospective reading by six experienced breast radiologists and classified using BI-RADS. The ...
Ades Anthony E AE University of Bristol, School of Social and Community Medicine, Bristol, UK and University of Exeter Medical School, Exeter, UK - - 2014
Before their diagnosis, patients with cancer present in primary care more frequently than do matched controls. This has raised hopes that earlier investigation in primary care could lead to earlier stage at diagnosis. We re-analysed primary care symptom data collected from 247 lung cancer cases and 1235 matched controls in ...
Thomas Nancy E NE Department of Dermatology, University of North Carolina, Chapel Hill2Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel - - 2014
Previous studies have reported that histopathologically amelanotic melanoma is associated with poorer survival than pigmented melanoma; however, small numbers of amelanotic melanomas, selected populations, lack of centralized pathologic review, or no adjustment for stage limit the interpretation or generalization of results from prior studies. To compare melanoma-specific survival between patients ...
Addati T T Anatomic Pathology Unit, National Cancer Research Centre Istituto Tumori 'Giovanni Paolo II', Bari, - - 2014
TROP-2 (human trophoblast cell surface marker) is a gene-related protein expressed in trophoblastic cells, which is also present in a variety of epithelial cancers and whose overexpression has been found to correlate with a poor prognosis. We analysed the possibility of using the expression of TROP-2 to detect papillary thyroid ...
Wei Xu Biao XB Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, Yangpu District, Shanghai, 200433, People's Republic of China, - - 2014
Colorectal high-grade intraepithelial neoplasia is defined as a high-grade neoplastic lesion with no invasion of submucosa. Because pathological evaluation has inevitable sampling errors, invasive cancer may be underdiagnosed as high-grade intraepithelial neoplasia by regarding submucosa invasion as an indispensable criterion for malignancy. This study was to evaluate the reliability of ...
Berrocal Alfonso A Department of Oncology, Hospital General Universitario, Valencia, - - 2014
The incidence of malignant melanoma is increasing worldwide. In Spain, its incidence is increasing faster than any other cancer type, with a 5-year survival rate of about 85%. The impact and characteristics of malignant melanoma in the Spanish population can be ascertained from the national melanoma registry of the Academia ...
Nakamura Yuko Y Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, - - 2014
In cervical cancer screening programs, women with abnormal cytology results are referred to colposcopy for histological diagnosis. This study was designed to evaluate the sensitivity of colposcopic procedures for detecting cervical cancer and its precursor, cervical intraepithelial neoplasia (CIN). Women referred to colposcopy for abnormal cytology were enrolled from four ...
Kitada Masahiro M Department of Respiratory Center, Asahikawa Medical University, Asahikawa, Hokkaido, - - 2014
Background: We conducted a study on photodynamic diagnosis (PDD) using autofluorescence in video-assisted thoracic surgery for minute intrathoracic small dissemination or early malignant pleural mesothelioma.Methods: Autofluorescence is the spontaneous emission of light that occurs when mitochondria, lysosomes, and other intracellular organelles absorb light. In normal tissues, green autofluorescence of approximately ...
Nickfarjam Abolfazl A Medical Physics Department, Shahid Sadoughi University of Medical Sciences , Yazd , Iran - - 2014
Abstract Purpose: Irreversible electroporation (IRE) is a new tumour ablation method used in cancer treatment procedures. In a successful IRE treatment it is crucial to impose minimum thermal damage to the tumour and its surrounding healthy tissue, while subjecting the entire tumour to a strong electric field. Here we present ...
Albanna Amr S AS *Department of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; †Division of Pulmonary Diseases, Department of Internal Medicine; ‡Department of Oncology; and §Department of Pathology, Jewish General Hospital, McGill University, Montreal, - - 2014
As treatments for non-small-cell lung cancer (NSCLC) become personalized, cellular and molecular differentiation of the tumor is becoming the standard of care. Our objective is to compare the yield of different diagnostic procedures for cellular differentiation of NSCLC and analysis of epidermal growth factor receptor (EGFR) mutation. We evaluated all ...
Alshenawy Hanan AlSaeid HA Department of Pathology, Faculty of Medicine, Tanta University, 25 Hamdy Gado Street, Tanta 002, Egypt. Electronic address: - - 2014
Cervical dysplasia, a potentially precancerous lesion, has increased in young women. Detection of cervical dysplasia is important for reducing morbidity and mortality in cervical cancer. This study analyzes the immunohistochemical expression of p16, HPV L1 capsid protein and Ki-67 in cervical intraepithelial lesions, and correlates them with lesion grade to ...
Nakano Satoko S Department of Surgery, Kawaguchi Municipal Medical Center, Kawaguchi City, Saitama, Japan. Electronic address: - - 2014
In recent years, pathological diagnoses have been increasingly required, especially in small breast lesions, because malpractice lawsuits concerning erroneous cytological diagnoses have been commonly reported. Here, we retrospectively evaluated the significance of FNAC and VAB for small breast lesions using ultrasonography guidance. A total of 1383 cases for which ultrasonography-guided ...
East James E JE Translational Gastroenterology Unit, Experimental Medicine Division, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Headington, Oxford OX3 9DU, UK. Electronic address: - - 2014
Much of the flat or biopsy-only detected dysplasia in inflammatory bowel disease (IBD) that had historically warranted a colectomy can now be shown to be circumscribed lesions with dye-spray or advanced endoscopic imaging. These lesions are therefore amenable to endoscopic excision with close endoscopic follow-up, though are technically very challenging. ...
Iacucci Marietta - - 2014
The risk for developing dysplasia and colorectal cancer in patients with longstanding inflammatory bowel disease (IBD) involving the colon is well documented. Random biopsies during white-light, standard-definition colonoscopy (33 to 50 biopsies) with or without dye spraying chromoendoscopy has been the recommended strategy in North America to detect dysplastic lesions ...
Kashyap Raghava R Department of Nuclear Medicine and PET, American Institute of Oncology, Nallagandla, Hyderabad, Andhra Pradesh, - - 2014
Increase in glycolytic pathway, forms one of the major adaptations in various cancer types. This can be imaged using (18)F-fluoro-deoxyglucose positron emission tomography/computed tomography (FDG PET). The intensity of FDG avidity is an indirect marker of the grade of the tumor. We present a case where FDG PET demonstrated a ...
Singh Veena V Institute of Cytology and Preventive Oncology, India. - - 2014
To assess the performance of magnifying device, magnivisualizer as against standard optical colposcope for detecting the pre-cancerous and early cancerous lesions of uterine cervix. A total of 659 consecutive symptomatic women attending one of the units of gynae outpatient department, underwent unaided visual inspection followed by cytology, visual inspection of ...
Sankaye Smita Balwantrao SB Department of Pathology, Rural Medical College, PIMS (DU), Loni, Ahmednagar, Maharashtra, - - 2014
Benign as well as malignant breast lesions are quite common in Indian population. It is the second most common cancer site after cancer cervix. Fine-needle aspiration cytology (FNAC) is safe, reliable, and time saving outdoor procedure with little discomfort to the patient. FNAC is useful in diagnosis and further planning ...
Ohishi Tsuyoshi T Department of Orthopaedic Surgery, Enshu Hospital, 1-1-1 Chuo, Naka-ku, Hamamatsu, Shizuoka 430-0929, - - 2014
Snapping phenomenon around the medial aspect of the knee is rare. We present this case of snapping knee caused by the sartorius muscle over a large medial meniscal cyst in a 66-year-old female. Magnetic resonance images demonstrated a large medial meniscal cyst with a horizontal tear of the medial meniscus. ...
Jarzemski Piotr P Department of Urology, Jan Biziel University Hospital, Ujejskiego 75 Street, 85-168 Bydgoszcz, Poland. - - 2014
Seminal vesicle cysts are rarely diagnosed, but symptomatic congenital seminal vesicle cysts are reported in the literature describing Zinner syndrome. Case Description: We present the case of a 26-year-old patient admitted to the urology department because of abdominal pain. A left seminal vesicle cyst and left kidney agenesis were found ...
Aydin Ibrahim I Department of Surgery, Recep Tayyip Erdogan University, School of Medicine, Rize, Turkey. Electronic address: - - 2014
Gastric polyps are usually found incidentally during upper gastrointestinal endoscopic examinations. These polyps are generally benign, with hyperplasia being the most common. While gastric polyps are often asymptomatic, they can cause gastric outlet obstruction. A 64 years-old female patient presented to our polyclinic with a history of approximately 2 months ...
Han Xiao X Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, - - 2014
Gastrointestinal neuroendocrine neoplasms (GI-NENs) are often located in the deep mucosa or submucosa, and the efficacy of endoscopic biopsy for diagnosis and treatment of GI-NENs is not fully understood. The current study analyzed GI-NENs, especially those diagnosed pathologically and resected endoscopically, and focused on the biopsy and cold biopsy forceps ...
Thewjitcharoen Yotsapon Y Division of Endocrine and Metabolism, Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University, - - 2014
Pituitary metastasis is an uncommon first presentation of systemic malignancy. The most common presenting symptom of pituitary metastasis is diabetes insipidus reflecting involvement of the stalk and/or posterior pituitary. We herein present a unique case of the coexistence of both a functioning pituitary adenoma (prolactinoma) and pituitary metastasis of advanced ...
Mărgăritescu Irina I Laboratory of Anatomic Pathology, "Onco Team Diagnostic", Bucharest, Romania; - - 2014
Complete regression of primary cutaneous melanoma is a very rare phenomenon. Only 49 cases of well-documented completely regressed primary cutaneous melanoma have been reported to date. The clinical picture and histological findings may vary considerably. The presence of regional lymphadenopathy represents a necessary requisite for the diagnosis of completely regressed ...
Woliński Kosma - - 2014
Thyroid nodular goitre is one of the most common endocrine disorders. Differentiating between benign and malignant lesions is an emerging challenge in endocrinological practice. Ultrasonography (US) remains the most commonly applied method in the preliminary assessment of lesions and is the basis for the decision as to fine needle aspiration ...
Chen Qi-Wen QW Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, - - 2014
Hepatocellular carcinoma (HCC) can be diagnosed by noninvasive approaches with serum α-fetoprotein (AFP) levels >200 ng/ml and/or a radiological imaging study of tumor mass >2 cm in patients with chronic liver disease. Percutaneous fine needle aspiration (FNA) under ultrasound (US) guidance has a diagnostic specificity of 95% and is superior ...
Zhao Ming M Department of Pathology, Ningbo Yinzhou Second Hospital Ningbo, Zhejiang 315100, PR China ; Current address: Department of Pathology, Zhejiang Provincial People's Hospital Hangzhou, Zhejiang 310014, PR - - 2014
Cystic lymphangioma of the adrenal gland is a rare and benign lesion, most often found incidentally during abdominal imaging studies, abdominal surgery or at autopsy. We aimed to retrospectively review all adrenal lymphangioma cases at our hospital, further document their lymphatic origin by immunohistochemical staining and discuss the differential diagnosis ...
Barbhuiya Mustafa M Centre for Genomics, Jiwaji University, Gwalior, Madhya Pradesh, - - 2014
Patients presenting with mass lesions of liver and gallbladder are a common occurrence in a cancer hospital in north central part of India. Fine-needle aspiration cytology (FNAC) serves as first line of pathological investigations, but there are pros and cons involved. The main objective of the present study was to ...
Kemp Marnie Laura ML Department of Diagnostic Radiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. - - 2014
Introduction. Breast lesions that appear benign on ultrasound examination continue to be biopsied, and no relevant data from Africa exist.Objective. To determine the histological spectrum of sonographically benign lesions measuring &gt;3 cm in women in Johannesburg, South Africa, by age and population group, and establish associations between the histological findings ...
Li Lei L Zhenjiang Key Laboratory of Molecular Endocrinology; Affiliated Hospital of Jiangsu University, Zhenjiang, China E-mail : - - 2014
The aim of this meta-analysis was to compare sensitivities and specificities of fine needle aspiration (FNA) and core needle biopsy (CNB) in the diagnosis of thyroid cancer. Articles were screened in Medline, the Cochrane Library, EMBASE and Google Scholar, and subsequently included and excluded based on the patient/problem-intervention-comparison-outcome (PICO) principle. ...
Sathyamurthy Anjana - - 2013
Gangliocytic paraganglioma is a rare neuroendocrine tumor predominantly arising in the second part of the duodenum with rare local recurrence or metastasis to regional lymph nodes. A 92-year-old female presented with obstructive jaundice. On exam she had pale conjunctiva and icteric sclera. Abdominal examination revealed tenderness in the upper abdomen. ...
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