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Kim Hakushi H Department of Urology, Tokai University Hachioji Hospital, Hachioji, Tokyo 192-0032, - - 2014
The present study reports a case of prostate adenocarcinoma with cyst formation. A 72-year-old male diagnosed with multiple lung metastases at a local clinic was referred to Tokai University Hachioji Hospital (Tokyo, Japan) for detection of a primary lesion. Whole body positron emission tomography/computed tomography showed strong accumulation of [(18)F]-fluoro-deoxy-2-glucose ...
Sakellariou Vasileios I VI 1st Department of Orthopaedic Surgery, ATTIKON University General Hospital, University of Athens, 1 Rimini Street, 12462, Chaidari, Greece, - - 2014
Multiple myeloma is a malignancy of monoclonal plasma cells (plasma cells are of B-lymphocyte lineage of the hematopoietic system). It is the second most prevalent blood malignancy after non-Hodgkin's lymphoma. It accounts for approximately 1 % of all malignancies and 2 % of all cancer deaths. Bony involvement is very common; the ...
Rodrigues Phamilla Gracielli Sousa PG Sao Carlos Institute of Physics, University of Sao Paulo (USP), Biophotonics Laboratory, Sao Carlos-SP, Brazil. - - 2014
Photodynamic therapy (PDT) is used for skin treatments of premalignant and cancer lesions and recognized as a non-invasive technique that combines tissue photosensitization and subsequent exposure to light to induce cell death. However, it is limited to the treatment of superficial lesions, mainly due to the low cream penetration. Therefore, ...
Wang Jayson J Department of Histopathology, Imperial College London, - - 2014
Mucins are a family of glycoproteins expressed by epithelial cells. They show specific tissue type expression, and are useful for differentiating between different cancers. Studies have shown changes in mucins expression with tumour progression in a variety of cancers. Here, we characerize the profile of mucins expression in benign, borderline ...
Timms John F JF EGA Institute for Women's Health, University College London, - - 2014
Ovarian cancer is a devastating disease and biomarkers for its early diagnosis are urgently required. Serum may be a valuable source of biomarkers which may be revealed by proteomic profiling. Herein, complementary serum protein profiling strategies were employed for discovery of biomarkers that could discriminate cases of malignant and benign ...
Shim Choong Nam CN Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Korea, - - 2014
Safety of endoscopic resection (ER) for early gastric cancers (EGC) with mixed histology predominantly of differentiated type has not been securely established, since those lesions tend to exhibit lymph node metastasis, compared to pure differentiated type. The purpose of this study was to evaluate clinicopathologic characteristics, therapeutic outcomes, and risk ...
Chang Jung Min JM Department of Radiology, Seoul National University Hospital, Seoul, Republic of - - 2014
Automated breast ultrasound (ABUS) is gaining popularity for breast cancer detection and diagnosis with its high reproducibility. Consistent recognition of breast lesions on serial exams is critical, and high reproducibility for lesion characterization is expected with ABUS, but not well reported. To retrospectively evaluate the reproducibility of ABUS for mass ...
Mascalchi Mario M From the *"Mario Serio" Department of Experimental and Clinical Biomedical Sciences, University of Florence; †Quantitative and Functional Radiology Research Program at Meyer Children and Careggi Hospitals of Florence, Florence; ‡Cardio-Thoracic Radiology, Cardio-Thoracic-Vascular Department, Sant'Orsola-Malpighi University-Hospital, Bologna; §Nuclear Medicine Unit, "Le Scotte" University Hospital, Siena; ∥Division of Pneumonology, Careggi Hospital, Florence; and ¶Nuclear Medicine Department, Sant'Orsola-Malpighi University-Hospital, Bologna, - - 2014
This study aimed to define computed tomographic morphologic features of lung cancer associated with cystic airspaces, their modifications in serial computed tomographic scans, and F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography uptake. Computed tomographic scans and F-FDG positron emission tomography in 24 patients with lung cancer (17 adenocarcinomas, 7 squamous cell carcinomas, ...
Collins Laura C LC 1Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA 2Faculdade de Medicina Universidade Federal de Minas Gerais Belo Horizonte, MG, Brazil 3South Australia Pathology, Adelaide, SA, - - 2014
The purpose of this course will be to provide pathologists with an update on breast core needle biopsy procedures using examples of such cases to address areas of recurrent diagnostic difficulty. The educational needs we will be targeting are primarily medical knowledge. We will select cases that constitute recurrent diagnostic ...
Kawai Toshiaki T 1National Defense Medical College 2Tokyo Womens Medical University Yachiyo Medical Center 3Yamaguchi Grand Medical Center 4Toda Central Medical Laboratory, - - 2014
Mesotheliomas produce body cavity effusion in about 70% of cases. Their cytologic diagnosis is hindered by the existence of a wide range of sensitivities, (according to the guidelines for pathologic diagnosis of malignant mesothelioma) and by the absence of a key histologic diagnostic feature, invasion of tumor cells into preexisting ...
Tanaka Shinya S Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, - - 2014
We have recently developed a new rapid IHC method (R-IHC) based on an alternating current (AC) electric field to facilitate the antigen-antibody reaction. By using this R-IHC method, reaction time of primary antibody can be almost 5 min. and entire procedure of IHC can be accomplished within 20 min. This R-IHC method ...
Lam Michael M Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore 308433, Republic of - - 2014
The most common type of intraocular tumor in adults is the metastatic variety, with the choroid as the typical site of involvement. The case of a patient with non-small cell lung cancer, who presented with choroidal metastasis, is described in the current report. In addition, the limitation of using a ...
Kauffmann Rondi M RM Department of General Oncologic Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010-3000, - - 2014
Melanoma continues to be one of the fastest growing cancers in terms of incidence. The workup of melanoma focuses on risk factors based on the visual aspects of a skin lesion. Risk factors including sun exposure increase the risk of melanoma. Staging is based on depth of invasion, mitotic rate, ...
Stubblefield Jonathan J School of Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, - - 2014
Melanoma is the most dangerous form of skin cancer and the sixth leading cause of malignancy in the United States. Non-Caucasians have a decreased overall incidence of melanoma, but African Americans and other ethnic groups often have more advanced disease at initial diagnosis and higher mortality rates than Caucasian populations. ...
Wollina Uwe U Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, 01067 Dresden, - - 2014
Cutaneous mosaicism is a possible cause of segmental skin diseases. Cutaneous leiomyomatosis represent a spectrum of conditions ranging from single lesions to disseminated wide distribution. Reed's syndrome, is an autosomal dominant disorder characterized by multiple cutaneous and uterine leiomyomas. We observed a segmental cutaneous piloleimyomatosis type 1 in a 55-year ...
Suhani Department of General Surgery, Lady Hardinge Medical College, New Delhi, - - 2014
Epidermal, or inclusion, cysts are frequently seen benign lesions that are lined with stratified squamous epithelium. Malignant transformation of these is rare, occurring in 0.011% to 0.045% cases [1]. We herein report an unusual case of squamous cell carcinoma occurring in an epidermal cyst of the breast in a middle ...
Tan Jieying J Department of Medical Imaging, Guangzhou Nansha Central Hospital, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong Province, 510150, People's Republic of - - 2014
The aim of this study is to perform a meta-analysis to evaluate the diagnostic performance of the in vivo post-contrast proton magnetic resonance spectroscopy (MRS) for benign/malignant discrimination of focal breast lesions. Sixteen studies with a total of 661 malignant breast lesions and 388 benign breast lesions were included. The ...
Mazziotti Silvio S Department of Biomedical Sciences and Morphological and Functional Imaging, University of Messina, Messina, Italy. Electronic address: - - 2014
Neoplasms of retromolar trigone have important peculiarities due to their spatial relationships with the surrounding structures. Tumours that involve this area can extend to nearby muscles; adipose spaces; and other anatomic structures, such as the soft palate, the tonsillar fossa, the parapharyngeal space, and the floor of the mouth. In ...
Iima Mami - - 2014
The purpose of this study was to explore the potential of non-Gaussian diffusion and perfusion magnetic resonance imaging (MRI) using intravoxel incoherent motion (IVIM) MRI for the diagnosis of breast lesions. This study included 26 women with breast lesions. Diffusion-weighted images were acquired using 16 b values up to 2500 ...
Bogosavljević Vojislav - - 2014
Objectives Comparison of redox conditions in malignant and benign tumours is essential for understanding the role of reactive oxygen species in the pathophysiology of aggressive cancer profiles. Here we compare antioxidative systems in highly malignant brain tumour - glioblastoma multiforme (GBM), and in meningioma, a benign brain tumour. Methods Tumour ...
Pereira A K C - - 2014
ABSTRACT Background The genesis of the endometrial polyp is as yet unclear. There is evidence that the polyp is related to the inflammatory process and that it interacts with the COX-2 enzyme. Objective To review the influence of COX-2 on the postmenopausal endometrial polyp. Methods Search Strategy: A systematic review ...
Ronot Maxime M Department of Radiology, APHP, University Hospitals Paris Nord Val de Seine, Beaujon, Clichy, Hauts-de-Seine, France, - - 2014
To prospectively assess the stiffness of incidentally discovered focal liver lesions (FLL) with no history of chronic liver disease or extrahepatic cancer using shearwave elastography (SWE). Between June 2011 and May 2012, all FLL fortuitously discovered on ultrasound examination were prospectively included. For each lesion, stiffness was measured (kPa). Characterization ...
Hussain Alia Arif AA Department of Dermatology, Roskilde Hospital, University of Copenhagen, Køgevej 7-13, 4000, Roskilde, Denmark, - - 2014
Since its introduction in dermatology in the late 1990s optical coherence tomography (OCT) has been used to study many skin diseases, in particular non-melanoma skin cancer and it s precursors. Special attention has been paid to superficial basal cell carcinoma (BCC), and a number of smaller observational studies have been ...
Zhang Lei L Departments of *Pathology, Cytopathology Division †Pathology, Surgical Pathology Division, The University of Chicago, Chicago, - - 2014
Indeterminate thyroid nodules form a heterogenous group of lesions that constitute 5% to 30% of thyroid cytology diagnoses. We introduce a triple immunostaining protocol for subtyping. Galectin-3, HBME-1, and p27 triple immunostaining, performed on destained cytology slides and formalin-fixed paraffin-embedded tissue, was developed and applied to 51 patients retrospectively with ...
Martinez Victor D VD BC Cancer Research Centre, Department of Integrative Oncology, Vancouver, - - 2014
Worldwide, oral cancer is responsible for 170,000 deaths per year. Intervention to prevent this disease is a long sought after goal. Chemoprevention studies have focused on clinicopathological features of potentially malignant lesions (PML) in an effort to prevent their progression to cancer. However, prediction of future behavior for such lesions ...
Zografos G G Breast Unit, University of Athens School of Medicine, Athens, Greece, - - 2014
To demonstrate the use of a new 3D diagnostic imaging technology, termed Multimodal Ultrasonic Tomography (MUT), for the detection of solid breast lesions < 15 mm in maximum dimension. 3D MUT imaging was performed on 71 volunteers presenting BIRADS-4 nodules, asymmetrical densities, and architectural distortions in X-ray mammograms, who subsequently underwent biopsy. MUT ...
Bayanati Hamid H Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, The Ottawa Hospital Research Institute, 501 Smyth Road, Box 232, Ottawa, ON, Canada, K1H - - 2014
To assess the accuracy of CT texture and shape analysis in the differentiation of benign and malignant mediastinal nodes in lung cancer. Forty-three patients with biopsy-proven primary lung malignancy with pathological mediastinal nodal staging and unenhanced CT of the thorax were studied retrospectively. Grey-level co-occurrence and run-length matrix textural features, ...
Laine Mustapha - - 2014
Tracheobronchopathia osteochondroplastica (TO) is a rare disorder of unknown cause affecting the large airways. It is characterized by the accumulation of bony and cartilaginous nodules in the tracheal and bronchial mucosa.Approximately 300 cases of tracheobronchopathia osteochondroplastica have been reported since Wilks first identified it in 1857. Tomography and computed tomography ...
Choi Seon Hyeong SH Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Radiology, School of Medicine, Graduate School, Hanyang University, Seoul, Korea. Electronic address: - - 2014
Papillary neoplasms of the breast comprise a broad range of pathologies ranging from papillomas to papillary carcinomas and have been associated with breast cancers. In this study, we evaluated the clinical, mammographic and sonographic features of papillary breast neoplasms from benign papillary breast lesions to malignancy-associated papillary lesions. A total ...
Gleason Joseph M JM Division of Urology, The Hospital for Sick Children, Department of Surgery, The University of Toronto, Toronto, ON, Canada; Division of Pediatric Urology, LeBonheur Children's Hospital, Department of Urology, The University of Tennessee, Memphis, TN, USA. Electronic address: - - 2014
To examine the presentation, diagnosis and management of radiologically diagnosed pediatric urachal anomalies and assess the risk of malignant degeneration. Our radiology database (2000-2012) was queried for all children under the age of 18 who were diagnosed with a urachal anomaly radiographically, and the operative database was utilized to determine ...
Mathur Aarti A Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, - - 2014
The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) describes several subcategories within atypia of undetermined significance (AUS), including (1) presence of focal nuclear atypia (AUS-N), (2) focal microfollicular proliferation (AUS-F), (3) focal Hürthle cell proliferation (AUS-HC), and (4) other (AUS-O). Several publications suggest that 5-15% is an underestimate of the ...
Chen Limin L Department of Ultrasound Diagnosis, Wenzhou Central Hospital, Jiangbin West Rd, Wenzhou, 325000, China, - - 2014
To examine the performance of shear-wave elastography (SWE) for the differentiation of benign and malignant breast lesions using a meta-analysis. PubMed, Embase and the Cochrane library were searched for studies published up to January 2014. The references of retrieved relevant articles were reviewed to identify potential publications. Random-effect meta-analysis was ...
Bradley Maria M Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Dermatology and Venereology, Karolinska University Hospital, Stockholm, - - 2014
The rare autosomal dominant condition Birt-Hogg-Dubé syndrome (BHD) is attributed to mutations on chromosome 17 in the folliculin (FLCN) gene, but not always diagnosed due to lack of, or a variety of symptoms such as fibrofolliculomas, lung cystic lesions, spontaneous pneumothorax and renal cancer. We hypothesized that the lack of ...
Zhou JianQiao J Department of Ultrasound, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200025, - - 2014
To compare the diagnostic performance of the fat-to-lesion strain ratio (FLR) and gland-to-lesion strain ratio (GLR) in the diagnosis of breast lesions. This was an institutional ethics committee approved prospective study. One hundred and ninety-three breast lesions in 193 women (mean age, 46.03 ± 13.60 years, range 18-82 years) were examined with conventional and ...
Mehta Hiren J HJ Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, - - 2014
Endobronchial ultrasound-guided transbronchial fine-needle aspiration (EBUS-FNA) has gained acceptance as the diagnostic procedure of choice with which to sample hilar and mediastinal lymph nodes (LNs) for diagnosing and staging patients with lung cancer. Studies have shown that EBUS has a high positive predictive value; however, its negative predictive value (NPV) ...
Belum Viswanath Reddy VR Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New - - 2014
The use of BRAF inhibitors may lead to the development of cutaneous toxicities such as rashes, photosensitivity, alopecia, palmoplantar erythrodysesthesia, and proliferative skin lesions, including keratoacanthomas (KAs) and cutaneous squamous cell carcinomas (cuSCCs). The latter are noteworthy for their potential to exhibit malignant features, and they may necessitate invasive treatment. ...
Lourenco Ana P AP 1 Department of Diagnostic Imaging, Alpert Medical School of Brown University, Rhode Island Hospital, Main Bldg, 3rd Fl, 593 Eddy St, Providence, RI - - 2014
OBJECTIVE. The purpose of this article is to determine the underestimation rate of high-risk lesions diagnosed at MRI-guided breast biopsy. MATERIALS AND METHODS. This was a retrospective review of 446 MRI-guided breast biopsies from January 2006 through December 2010. Data were collected on examination indication, lesion size and type, and ...
Kuzmiak Cherie M CM Department of Radiology, University of North Carolina Lineberger Comprehensive Cancer Center (C.M.K.), Department of Medicine, Center for Gastro intestinal Biology and Disease (M.Q.L.), and Department of Biostatistics (D.Z., X.L.), University of North Carolina, Chapel Hill, North Carolina USA. - - 2014
The purpose of this retrospective study was to assess the sonographic features of benign, high-risk, and malignant papillary lesions of the breast. We conducted a search of our institution's breast biopsy database for all papillary lesions with sonographic findings and final surgical pathologic diagnoses from January 1, 2004, to December ...
Howard Daniel - - 2014
Squamous cell carcinoma is the second most common type of skin cancer and may present in the distal extremities including the foot. We present a case in which a primary squamous cell carcinoma of the foot, which presented as a granulomatous ulcerating lesion, was diagnosed and successfully treated with a ...
Kang Yun Kyung YK Department of Pathology, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, - - 2014
Recent progress in advanced endoscopic imaging and electronic chromoendoscopy allows the real-time endoscopic estimation of the histologic type of polyps, mainly for the differentiation of adenomas from hyperplastic polyps. Accordingly, a "resect-and-discard" strategy applied to diminutive colorectal polyps is now one of the emerging issues among gastroenterologists. The strategy has ...
Schimmöller L L Univ Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Moorenstr. 5, D-40225 Dusseldorf, Germany. Electronic address: - - 2014
This study evaluates the diagnostic value of the ESUR scoring system (PI-RADS) regarding prostate cancer detection using MR-guided in-bore biopsies (IB-GB) as the reference standard. 566 lesions in 235 consecutive patients (65.7±7.9 years, PSA 9.9±8.5ng/ml) with a multiparametric (mp)-MRI (T2WI, DWI, DCE) of the prostate at 3T were scored using ...
Tagliafico Alberto A Institute of Anatomy, Department of Experimental Medicine (DIMES), University of Genoa, Largo Rosanna Benzi 8, 16132, Genoa, Italy, - - 2014
To compare DBT and FFDM in the classification of microcalcification clusters (MCs) using BI-RADS. This Institutional Review Board-approved study was undertaken in three centres. A total of 107 MCs evaluated with both DBT and FFDM were randomised for prospective reading by six experienced breast radiologists and classified using BI-RADS. The ...
Ades Anthony E AE University of Bristol, School of Social and Community Medicine, Bristol, UK and University of Exeter Medical School, Exeter, UK - - 2014
Before their diagnosis, patients with cancer present in primary care more frequently than do matched controls. This has raised hopes that earlier investigation in primary care could lead to earlier stage at diagnosis. We re-analysed primary care symptom data collected from 247 lung cancer cases and 1235 matched controls in ...
Thomas Nancy E NE Department of Dermatology, University of North Carolina, Chapel Hill2Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel - - 2014
Previous studies have reported that histopathologically amelanotic melanoma is associated with poorer survival than pigmented melanoma; however, small numbers of amelanotic melanomas, selected populations, lack of centralized pathologic review, or no adjustment for stage limit the interpretation or generalization of results from prior studies. To compare melanoma-specific survival between patients ...
Addati T T Anatomic Pathology Unit, National Cancer Research Centre Istituto Tumori 'Giovanni Paolo II', Bari, - - 2014
TROP-2 (human trophoblast cell surface marker) is a gene-related protein expressed in trophoblastic cells, which is also present in a variety of epithelial cancers and whose overexpression has been found to correlate with a poor prognosis. We analysed the possibility of using the expression of TROP-2 to detect papillary thyroid ...
Wei Xu Biao XB Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 225 Changhai Road, Yangpu District, Shanghai, 200433, People's Republic of China, - - 2014
Colorectal high-grade intraepithelial neoplasia is defined as a high-grade neoplastic lesion with no invasion of submucosa. Because pathological evaluation has inevitable sampling errors, invasive cancer may be underdiagnosed as high-grade intraepithelial neoplasia by regarding submucosa invasion as an indispensable criterion for malignancy. This study was to evaluate the reliability of ...
Berrocal Alfonso A Department of Oncology, Hospital General Universitario, Valencia, - - 2014
The incidence of malignant melanoma is increasing worldwide. In Spain, its incidence is increasing faster than any other cancer type, with a 5-year survival rate of about 85%. The impact and characteristics of malignant melanoma in the Spanish population can be ascertained from the national melanoma registry of the Academia ...
Nakamura Yuko Y Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba, 305-8575, - - 2014
In cervical cancer screening programs, women with abnormal cytology results are referred to colposcopy for histological diagnosis. This study was designed to evaluate the sensitivity of colposcopic procedures for detecting cervical cancer and its precursor, cervical intraepithelial neoplasia (CIN). Women referred to colposcopy for abnormal cytology were enrolled from four ...
Kitada Masahiro M Department of Respiratory Center, Asahikawa Medical University, Asahikawa, Hokkaido, - - 2014
Background: We conducted a study on photodynamic diagnosis (PDD) using autofluorescence in video-assisted thoracic surgery for minute intrathoracic small dissemination or early malignant pleural mesothelioma.Methods: Autofluorescence is the spontaneous emission of light that occurs when mitochondria, lysosomes, and other intracellular organelles absorb light. In normal tissues, green autofluorescence of approximately ...
Martinez Melissa M Melissa Martinez, Julia LeBlanc, Mohammad Al-Haddad, Stuart Sherman, John DeWitt, Department of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, United - - 2014
To report the clinical impact of adrenal endoscopic ultrasound fine-needle aspiration (EUS-FNA) in the evaluation of patients with adrenal gland enlargement or mass. In a retrospective single-center case-series, patients undergoing EUS-FNA of either adrenal gland from 1997-2011 in our tertiary care center were included. Medical records were reviewed and results ...
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