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Jatana Kris R KR Department of Otolaryngology-Head and Neck Surgery, Nationwide Children's Hospital, The Ohio State University, 555 South 18th Street, Suite 2A, Columbus, OH 43205, - - 2015
Proper management of pediatric thyroid nodules is crucial to achieving good outcomes. It is important to obtain a thorough history, including prior radiation exposure and family history of thyroid cancer and any symptoms of hypothyroidism or hyperthyroidism. A complete physical examination with special attention to the thyroid gland and any ...
Stewart Colin J R CJ Department of Histopathology (C.J.R.S., M.L.C.), King Edward Memorial Hospital, Subiaco, Perth School for Women's and Infants' Health (C.J.R.S.), University of Western Australia, WA, - - 2015
Microglandular hyperplasia (MGH) is a common endocervical alteration that in most cases presents no diagnostic difficulty. However, MGH rarely shows atypical features that may mimic endocervical neoplasia, while conversely endometrial carcinomas can show deceptively bland MGH-like appearances. It has been suggested that immunohistochemical analysis is useful in this context, but ...
Tang Zhonghao Z Department of Pulmonary Medicine, Huadong Hospital, Fudan University, 200040, Shanghai, - - 2015
The aims of this study were as follows: to analyze the forkhead box M1 (FoxM1) expression in benign and malignant pleural effusion by reverse transcription-polymerase chain reaction assay (RT-PCR); to explore the role of FoxM1 in formation and progress in malignant pleural effusion, and whether there is significant difference in ...
Zhu Ling Yin LY State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Cancer Institute, Shanghai Institute of Digestive Disease, Shanghai, - - 2014
The study aims to clarify the role of narrow band imaging (NBI) in the prediction of invasion depth and the formation of lesion appearance under NBI with immunohistochemical analysis. As a prospective single-center study, Sano's classification of capillary pattern (CP) was applied to differentiate early colorectal neoplasms under NBI observation. ...
Nishii Yuko Y Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka 545-8585, - - 2014
Minimal deviation adenocarcinoma (MDA), also known as adenoma malignum of the uterine cervix, accounts for only ~1% of uterine cervical adenocarcinomas. Adenoma malignum of the uterine cervix was initially described by Gusserow in 1870. Using magnetic resonance imaging (MRI), MDA appears as multilocular lesions with solid components that extend from ...
Malhi Harshawn H 1 Department of Radiology, Keck School of Medicine, University of Southern California, 1500 San Pablo St, Los Angeles, CA - - 2014
OBJECTIVE. This study was undertaken to define and evaluate echogenic foci and their posterior acoustic artifacts in thyroid nodules. Whether these findings were indicative of benignity or malignancy was assessed. MATERIALS AND METHODS. Echogenic foci were classified into five types: no posterior artifact, large comet-tail artifact, small comet-tail artifact (≤ ...
Jansen Marnix M Department of Pathology, Academic Medical Center, Amsterdam, the - - 2014
Endoscopic radiofrequency ablation (RFA) appears to be a safe and effective treatment for flat-type noninvasive squamous neoplasia of the esophagus. However, if RFA is applied to lesions containing invasive cancer (esophageal squamous cell carcinoma [ESCC]), histological features associated with lymph node metastases may remain undetected. In addition, extension of neoplasia ...
Malkan Alpin D AD Departments of - - 2014
Renal masses in children may be discovered during routine clinical examination or incidentally during the course of diagnostic or therapeutic procedures for other causes. Renal cancers are rare in the pediatric population and include a spectrum of pathologies that may challenge the clinician in choosing the optimal treatment. Correct identification ...
Tjwa Eric T T L ET Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, PO box 2040, 3000 CA, Rotterdam, The Netherlands. Electronic address: - - 2014
Upper gastrointestinal bleeding (UGIB) is the most common emergency condition in gastroenterology. Although peptic ulcer and esophagogastric varices are the predominant causes, other conditions account for up to 50% of UGIBs. These conditions, among others, include angiodysplasia, Dieulafoy and Mallory-Weiss lesions, gastric antral vascular ectasia, and Cameron lesions. Upper GI ...
Inoue Tadahisa T Department of Gastroenterology, Gifu Prefectural Tajimi - - 2014
We encountered two cases of malignant lymphoma with peritoneal localization complicated by sigmoid colon cancer and hepatocellular carcinoma. Multiple primary cancers were suspected on the basis of differences in absorption values on computed tomography (CT) and differences in the degree of accumulation on positron emission tomography CT; however, a definitive ...
Kallini Joseph R JR Department of Internal Medicine, Eisenhower Medical Center, Rancho Mirage, CA, USA; School of Medicine, Baylor College of Medicine, Houston, TX, - - 2014
Squamous cell carcinoma (SCC) is the second most common non-melanoma skin cancer. It originates from epidermal keratinocytes or adnexal structures (such as eccrine glands or pilosebaceous units). We describe the salient features of cutaneous SCC. We also review novel classification schemes proposed during the last decade which attempt to stratify ...
Fernández-Figueras M T MT Department of Anatomic Pathology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, - - 2014
Progression from actinic keratosis (AK) to invasive squamous cell carcinoma (iSCC) of the skin is thought to occur after the development of full thickness epidermal neoplasia, as in the classic pathway of cervical cancer. Nevertheless, cutaneous iSCC may also directly arise from a proliferation of atypical basaloid cells limited mostly ...
Wentzensen Nicolas N Nicolas Wentzensen, Barry I. Graubard, Sholom Wacholder, and Mark Schiffman, National Cancer Institute, Bethesda, MD; Joan L. Walker, Katie M. Smith, Rosemary E. Zuna, Cara Mathews, S. Terence Dunn, Roy Zhang, Katherine Moxley, Erin Bishop, Meaghan Tenney, and Elizabeth Nugent, University of Oklahoma Health Sciences Center, Oklahoma City; and Michael A. Gold, Tulsa Cancer Institute and University of Oklahoma School of Community Medicine, Tulsa, OK. - - 2014
Women with abnormal cervical cancer screening results are referred to colposcopy and biopsy for diagnosis of cervical cancer precursors (high-grade squamous intraepithelial lesions [HSILs]). Colposcopy with a single biopsy can miss identification of HSILs. No systematic study has quantified the improved detection of HSIL by taking multiple lesion-directed biopsies. The ...
Barr Richard G RG From the Department of Radiology, Northeastern Ohio Medical University, Rootstown, Ohio (R.G.B.); Radiology Consultants Inc, 7623 Market St, Boardman, OH 44512 (R.G.B.); and Department of Biostatistics and Center for Statistical Sciences, Brown University, Providence, RI - - 2014
Purpose To determine whether addition of quality measure ( QM quality measure ) of shear-wave ( SW shear wave ) velocity ( Vs SW velocity ) estimation can increase SW shear wave elastography sensitivity for breast cancer. Materials and Methods With written informed consent, this institutional review board-approved, HIPAA-compliant study ...
Chabowski Mariusz M Department of Surgery, Fourth Military Teaching Hospital, 5 Weigla St., 50-981, Wroclaw, Poland, - - 2014
Our experience of using mediastinoscopy for the diagnosis of enlarged mediastinal lymph nodes or mediastinal mass is presented in this study. We reviewed 54 consecutive patients (34 men and 20 women) with mediastinal pathology of varied etiologies who underwent a standard cervical mediastinoscopy from January to December 2012. The histological ...
Schlageter Manuel M Manuel Schlageter, Luigi Maria Terracciano, Department of Pathology, University Hospital Basel, 4031 Basel, - - 2014
Hepatocellular carcinoma (HCC) is currently the sixth most common type of cancer with a high mortality rate and an increasing incidence worldwide. Its etiology is usually linked to environmental, dietary or life-style factors. HCC most commonly arises in a cirrhotic liver but interestingly an increasing proportion of HCCs develop in ...
Badertscher Nina - - 2014
BackgroundThe rising incidence of melanoma ¿ Switzerland has the highest incidence in Europe - is a major public health challenge. Swiss dermatologist introduced the ¿Swiss Skin Cancer Day¿ (SSCD) in 2006, which provides skin cancer screening at no costs. The aim of the study was to describe the participating subjects ...
Chen Xinliang X Department of Clinical Laboratory, Sun Yat-Sen Memorial Hospital, Guangzhou, Guangdong 510080, PR - - 2014
HE4, a novel tumor marker for detecting ovarian cancer, has been recently applied to clinical practice. However, the comprehensive evaluation of HE4 combined with other markers is still missing. We evaluated an optimal mode of HE4 employment for differential diagnosis of benign and malignant pelvic masses. Serum HE4, CA125, CA153, ...
Schrading Simone S From the Department of Diagnostic and Interventional Radiology, University of Aachen, RWTH, Pauwelsstr 30, 52074 Aachen, - - 2014
Purpose To use digital breast tomosynthesis ( DBT digital breast tomosynthesis )-guided vacuum-assisted biopsy ( VAB vacuum-assisted biopsy ) to sample target lesions identified at full-field digital screening mammography and compare clinical performance with that of prone stereotactic ( PS prone stereotactic ) VAB vacuum-assisted biopsy . Materials and Methods ...
Chau Karen K Department of Cytopathology, North Shore-LIJ Health System, Lake Success, New - - 2014
At a high-volume center, it became necessary to provide benchmarks for the accuracy and risk of malignancy per urine cytology diagnostic category. The additive sensitivity for the determination of the residual risk of disease was calculated with the goal of determining the performance of cytology and optimal triage, including the ...
Kaltenbach Tonya T Veterans Affairs Palo Alto, GI Endoscopy Unit and Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California, - - 2014
Diminutive (≤5 mm) colorectal polyps are common, and overwhelmingly benign. Routinely, after polypectomy, they are examined pathologically to determine the surveillance intervals. Advances in equipment and techniques, such as narrow-band imaging (NBI) colonoscopy, now permit reliable real-time optical diagnosis. We conducted a randomised single-masked study involving three institutions to determine whether ...
Cohen J M JM Department of Dermatology, Brigham and Women's Hospital, Boston, MA, - - 2014
Cutaneous granulomatous eruptions comprise a rare subset of paraneoplastic dermatitides most commonly associated with haematologic malignancies. The pathogenesis of these eruptions remains poorly understood. Carcinoid tumours are uncommon neuroendocrine neoplasms that most often arise in the gastrointestinal tract and produce excess serotonin leading to diarrhoea and flushing. Metastases can result ...
Maeda Emiko E Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Kagawa 761-0793, - - 2015
Linitis plastica is a gastric cancer of diffuse histotype that presents in the fundic gland area, and is characterized by thickening of the stomach wall and deformation of the stomach, resulting in a leather bottle-like appearance. A 66-year-old female was admitted to Kagawa University Hospital (Kagawa, Japan) with epigastric pain. ...
Chen Clark C CC University of California, San Diego, San Diego, CA, - - 2014
Stereotactic biopsies are frequently performed to secure definitive diagnosis for brain tumor patients. Fundamentally, there are two major difficulties in these endeavors. First, because of intra-tumoral heterogeneity inherent in many forms of brain cancer, biopsies taken from one region may yield a different diagnosis than if another area is biopsied. ...
Xu Chaoli - - 2014
Automated breast volume scanner (ABVS) and US elastography (UE) have been useful for the differentiation of benign and malignant lesions. However, combining these two methods applied in diagnosis of breast lesions has not yet been reported. The aim of this study is to analyze the inter-examiner reliability of ABVS and ...
Kim Hakushi H Department of Urology, Tokai University Hachioji Hospital, Hachioji, Tokyo 192-0032, - - 2014
The present study reports a case of prostate adenocarcinoma with cyst formation. A 72-year-old male diagnosed with multiple lung metastases at a local clinic was referred to Tokai University Hachioji Hospital (Tokyo, Japan) for detection of a primary lesion. Whole body positron emission tomography/computed tomography showed strong accumulation of [(18)F]-fluoro-deoxy-2-glucose ...
Nakhlis Faina F Department of Surgery, Brigham and Womens Hospital, Boston, USA, - - 2014
Intraductal papillomas (IPs) are commonly seen breast lesions with variable clinical presentation. For a palpable lesion and/or evidence of cellular atypia and/or pathologic nipple discharge, excision is warranted to rule out adjacent carcinoma, while for asymptomatic IPs lacking atypia current data for excision vs. observation are controversial. We reviewed outcomes ...
Akbarzadeh-Jahromi Mojgan M Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, - - 2014
Adenoid cystic carcinoma of Bartholin's gland is a rare malignant tumor of female genital tract. We report a case of a 42-year-old woman, presenting a palpable painful mass and burning sensation on the left side of vulva during the preceding two months. Based on examination, a solid fixed painful nodule ...
Hoell J I JI Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University, Duesseldorf, - - 2014
Background: Cases of children with more than one type of cancer either diagnosed simultaneously or successively, rarely occur in pediatric oncology. A second malignant neoplasm may be caused by mutagenic effects of the treatment of the primary malignancy and/or may point towards an underlying genetic cancer susceptibility syndrome. One example ...
Cui Chao - - 2014
The serum level of Cyfra21-1 was always elevated in patients with nonsmall cell lung carcinoma. The aim of this meta-analysis was to evaluate the serum Cyfra21-1 as a biomarker in the diagnosis of nonsmall cell lung cancer (NSCLC). All the articles associated with serum Cyfra21-1 in the diagnosis of NSCLC ...
Ide Fumio F Division of Oral Pathology, Department of Diagnostic and Therapeutic Sciences, MeikaiUniversity School of Dentistry, Saitama, - - 2014
We would like to express our views regarding the recently published article by Mosqueda-Taylor et al.on primordial odontogenic tumour (POT), which they considered to be a previously undescribed, benign ectomesenchymal neoplasm. We agree with the authors that all six of the lesions presented have many features of interest and importance with ...
Sigel Carlie S CS Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New - - 2014
Identifying high-grade features in patients with pancreatic mucinous neoplasms (MNs) is important for patient management. The reproducibility of MN cytology grading has been evaluated to a limited extent. In the current study, the authors evaluated interobserver variability in grading MNs and the identification of neoplastic mucin in endoscopic ultrasound-guided fine-needle ...
Bordaçahar Benoît B Department of Gastroenterology, Cochin Teaching Hospital, AP-HP, Paris, - - 2014
Until the past two decades, almost all colorectal polyps were divided into two main groups: hyperplastic polyps and adenomas. Sessile serrated adenomas presented endoscopic, pathological and molecular profiles distinct from others polyps. Previously under-diagnosed, physicians now identified sessile serrated adenomas. The serrated neoplastic pathway is accounting for up to one-third ...
Uniyal Nishant - - 2014
This work reports the use of ultrasound radio frequency (RF) time series analysis as a method for ultrasoundbased classification of malignant breast lesions. The RF time series method is versatile and requires only a few seconds of raw ultrasound data with no need for additional instrumentation. Using the RF time ...
Lee Yoon Se YS Department of Otolaryngology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul 138-736, Republic of - - 2014
Specific circulating microRNAs (miRNAs) in each organ may contribute to the diagnosis and prognosis in some cancers. miRNA from papillary thyroid cancer (PTC) may be released into the bloodstream. This study was performed to detect miRNAs in the plasma and estimate their diagnostic usefulness for discriminating between benign and malignant ...
Qin Xiumin - - 2014
Endoscopic treatments for early esophageal squamous cell carcinoma and the esophageal neoplasm are two types: endoscopic resection (ER) and ablation. Resection enables evaluation of the lesion in the ER specimens, while ablation cannot. We sought to establish a pre-ER evaluated system with a diagnostic and staging accuracy similar to ER ...
Sakellariou Vasileios I VI 1st Department of Orthopaedic Surgery, ATTIKON University General Hospital, University of Athens, 1 Rimini Street, 12462, Chaidari, Greece, - - 2014
Multiple myeloma is a malignancy of monoclonal plasma cells (plasma cells are of B-lymphocyte lineage of the hematopoietic system). It is the second most prevalent blood malignancy after non-Hodgkin's lymphoma. It accounts for approximately 1 % of all malignancies and 2 % of all cancer deaths. Bony involvement is very common; the ...
Brun J-L JL Department of Gynaecology and Obstetrics, Pellegrin University Hospital, Bordeaux, France. Electronic address: - - 2014
Transvaginal pelvic ultrasound is the first-line imaging examination for presumed benign ovarian tumors (PBOT) in adult women (Grade A). Ultrasound is sufficient for characterizing a unilocular anechoic cyst smaller than 7cm (Grade A). Magnetic resonance imaging is the recommended second-line investigation for indeterminate masses or masses larger than 7cm (Grade ...
Abraham Nitya E NE Division of Urologic Oncology, Department of Urology, New York University School of - - 2014
The objectives of this study were to: 1) describe the patterns of repeat prostate biopsy utilization in men with previous negative biopsy, and 2) identify predictors of prostate cancer (CaP) diagnosis in these men on repeat biopsy. 1,837 men who underwent prostate biopsy between January 1, 1995 - January 1, ...
Ramírez-Galván Yazmín Aseret - - 2014
Diffusion-weighted imaging and apparent diffusion coefficient (ADC) of 36 breast lesions previously categorized as 4 according to the Breast Imaging Reporting and Data System (BI-RADS) were prospectively studied. The pathological results were 21 benign lesions and 15 malignant. The ADC of malignant lesions was significantly lower than that of the ...
Rodrigues Phamilla Gracielli Sousa PG Sao Carlos Institute of Physics, University of Sao Paulo (USP), Biophotonics Laboratory, Sao Carlos-SP, Brazil. - - 2014
Photodynamic therapy (PDT) is used for skin treatments of premalignant and cancer lesions and recognized as a non-invasive technique that combines tissue photosensitization and subsequent exposure to light to induce cell death. However, it is limited to the treatment of superficial lesions, mainly due to the low cream penetration. Therefore, ...
Wang Jayson J Department of Histopathology, Imperial College London, - - 2014
Mucins are a family of glycoproteins expressed by epithelial cells. They show specific tissue type expression, and are useful for differentiating between different cancers. Studies have shown changes in mucins expression with tumour progression in a variety of cancers. Here, we characerize the profile of mucins expression in benign, borderline ...
Timms John F JF EGA Institute for Women's Health, University College London, - - 2014
Ovarian cancer is a devastating disease and biomarkers for its early diagnosis are urgently required. Serum may be a valuable source of biomarkers which may be revealed by proteomic profiling. Herein, complementary serum protein profiling strategies were employed for discovery of biomarkers that could discriminate cases of malignant and benign ...
Shim Choong Nam CN Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Korea, - - 2014
Safety of endoscopic resection (ER) for early gastric cancers (EGC) with mixed histology predominantly of differentiated type has not been securely established, since those lesions tend to exhibit lymph node metastasis, compared to pure differentiated type. The purpose of this study was to evaluate clinicopathologic characteristics, therapeutic outcomes, and risk ...
Chang Jung Min JM Department of Radiology, Seoul National University Hospital, Seoul, Republic of - - 2014
Automated breast ultrasound (ABUS) is gaining popularity for breast cancer detection and diagnosis with its high reproducibility. Consistent recognition of breast lesions on serial exams is critical, and high reproducibility for lesion characterization is expected with ABUS, but not well reported. To retrospectively evaluate the reproducibility of ABUS for mass ...
Mascalchi Mario M From the *"Mario Serio" Department of Experimental and Clinical Biomedical Sciences, University of Florence; †Quantitative and Functional Radiology Research Program at Meyer Children and Careggi Hospitals of Florence, Florence; ‡Cardio-Thoracic Radiology, Cardio-Thoracic-Vascular Department, Sant'Orsola-Malpighi University-Hospital, Bologna; §Nuclear Medicine Unit, "Le Scotte" University Hospital, Siena; ∥Division of Pneumonology, Careggi Hospital, Florence; and ¶Nuclear Medicine Department, Sant'Orsola-Malpighi University-Hospital, Bologna, - - 2014
This study aimed to define computed tomographic morphologic features of lung cancer associated with cystic airspaces, their modifications in serial computed tomographic scans, and F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography uptake. Computed tomographic scans and F-FDG positron emission tomography in 24 patients with lung cancer (17 adenocarcinomas, 7 squamous cell carcinomas, ...
Collins Laura C LC 1Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA 2Faculdade de Medicina Universidade Federal de Minas Gerais Belo Horizonte, MG, Brazil 3South Australia Pathology, Adelaide, SA, - - 2014
The purpose of this course will be to provide pathologists with an update on breast core needle biopsy procedures using examples of such cases to address areas of recurrent diagnostic difficulty. The educational needs we will be targeting are primarily medical knowledge. We will select cases that constitute recurrent diagnostic ...
Kawai Toshiaki T 1National Defense Medical College 2Tokyo Womens Medical University Yachiyo Medical Center 3Yamaguchi Grand Medical Center 4Toda Central Medical Laboratory, - - 2014
Mesotheliomas produce body cavity effusion in about 70% of cases. Their cytologic diagnosis is hindered by the existence of a wide range of sensitivities, (according to the guidelines for pathologic diagnosis of malignant mesothelioma) and by the absence of a key histologic diagnostic feature, invasion of tumor cells into preexisting ...
Tanaka Shinya S Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, - - 2014
We have recently developed a new rapid IHC method (R-IHC) based on an alternating current (AC) electric field to facilitate the antigen-antibody reaction. By using this R-IHC method, reaction time of primary antibody can be almost 5 min. and entire procedure of IHC can be accomplished within 20 min. This R-IHC method ...
Lam Michael M Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore 308433, Republic of - - 2014
The most common type of intraocular tumor in adults is the metastatic variety, with the choroid as the typical site of involvement. The case of a patient with non-small cell lung cancer, who presented with choroidal metastasis, is described in the current report. In addition, the limitation of using a ...
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