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Lee Ha Young HY Department of Radiology, University of Inha School of Medicine, Incheon, - - 2014
Objective: The purpose of this study was to determine whether the recommended waiting period of 3 months is necessary for repeat fine-needle aspiration biopsy (FNAB). Study Design: A retrospective review of 128 nodules from 126 patients with initial nondiagnostic (ND) results was performed for the period between January 2009 and ...
Bhatnagar Ramneesh R Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Md., - - 2014
Background: Solid-pseudopapillary neoplasm (SPN) is a rare pancreatic malignancy with an excellent prognosis. It is most commonly diagnosed in young women. This article comprehensively reviews the clinical, pathological and radiological features of this neoplasm, as well as its clinical management. Methods: A literature review of SPN was performed of all ...
Yong Eric X Z EX Department of Neurosurgery, St Vincent's Hospital Melbourne, P.O. Box 2900, Fitzroy, VIC 3065, Australia. Electronic address: - - 2014
This clinical series examines the presentation of three adult patients who were found to have de novo anaplastic pilocytic astrocytoma. Initial imaging demonstrated an intracranial mass with histological analysis diagnostic of pilocytic astrocytoma with anaplastic features including necrosis, marked nuclear pleomorphism and a very high mitotic rate leading to the ...
VandenBussche Christopher J CJ Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Md., - - 2014
Introduction: The thyroid gland is arguably the fastest growing anatomic site for fine needle aspiration (FNA). With the increase of thyroid cases, a reevaluation of cytotechnologist screening quality metrics in terms of thyroid FNA is called for. We present our institutional cytotechnologist performance at screening for nuclear atypia by applying ...
Simeonov R R Department of General and Clinical Pathology, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, - - 2014
Stained cytological specimens from 24 dogs with spontaneous soft tissue sarcomas [fibrosarcoma (n = 8), liposarcoma (n = 8) and haemangiopericytoma (n = 8)], and 24 dogs with reactive connective tissue lesions [granulation tissue (n = 12) and dermal fibrosis (n = 12)] were analysed by computer-assisted nuclear morphometry. The studied morphometric parameters were: mean nuclear area (MNA; µm(2) ), ...
Pusztaszeri Marc P MP Department of Pathology, Geneva University Hospital, Geneva, - - 2014
Benign thyroid nodules with papillary hyperplasia (BTN-PH) are sometimes misinterpreted cytologically as papillary thyroid carcinoma (PTC). We evaluated a fine-needle aspiration biopsy (FNAB) series of BTN-PH to identify the causes of diagnostic error and to better define its cytologic criteria. A total of 48 FNAB cases of histologically confirmed BTN-PHs ...
Hartman Douglas J DJ From the Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA; - - 2014
The accurate diagnosis of malignancy from small bile duct biopsy specimens is often challenging. This proof-of-concept study assessed the feasibility of a novel optical technology, spatial-domain low-coherence quantitative phase microscopy (SL-QPM), that assesses nanoscale structural alterations in epithelial nuclei for improving the diagnosis of malignancy in bile duct biopsy specimens. ...
Li Xue-Ming XM Department of Radiology, Sichuan Cancer Hospital and Institute, Sichuan University, Chengdu, Sichuan 610041, P.R. - - 2014
Solitary fibrous tumors (SFTs) are a unique group of mesenchymal neoplasms of fibroblastic or myofibroblastic origin and are extremely rare in the oral cavity. The present study reported two additional cases of SFTs in the soft palate, along with the computed tomography characteristics, which demonstrated well-circumscribed soft tissue lesions with ...
Matoso Andres A Departments of *Pathology ∥Oncology ¶Urology, Johns Hopkins Hospital, Baltimore, MD †Department of Pathology, Rhode Island Hospital, Providence, RI ‡Department of Pathology, Medical College of Wisconsin, Milwaukee, WI §Department of Pathology, Emory University School of Medicine, Atlanta, - - 2014
Smooth muscle tumors of the scrotum are very uncommon, and those with degenerative-appearing atypia, variably designated as "atypical," "symplastic," or "bizarre" leiomyomas, are extremely rare with only 11 cases in the literature. Given their rarity, the diagnostic criteria and prognosis of symplastic leiomyomas are not well established. We describe 9 ...
Whittam Benjamin M BM Division of Pediatric Urology, Riley Hospital for Children at Indiana University School of Medicine, IN, USA. Electronic address: - - 2014
It is critical to differentiate between a multicystic dysplastic kidney (MCDK) and a kidney with severe hydronephrosis as the treatment varies significantly. We designed a study to compare renal ultrasound (RUS) to nuclear medicine (NM) scan in the diagnosis of MCDK, in order to determine if RUS can be used ...
Ambroggi Massimo - - 2014
Malignant mesothelioma is a rare neoplasm that generally develops in the pleural or peritoneal cavity. Distant metastases are common; it rarely metastatizes to the head and neck region. A 54-year-old white man, a non-smoker, was treated with chemotherapy, surgery and radiation for a malignant pleural mesothelioma. Seven months after the ...
Maeda Ichiro I Department of Pathology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, 216-8511, Japan, - - 2014
Some reports suggest that the rate of definitive diagnosis of malignant tumors, namely, the final diagnosis being revised to a higher stage, in patients diagnosed as having flat epithelial atypia (FEA) by percutaneous needle biopsy of the breast (PNB) is as low as 0-3 %. However, other reports suggest that the ...
Han Song-Hee SH Department of Pathology, Inje University Ilsan Paik Hospital, Goyang, Republic of - - 2014
Pigmented tumors rarely arise in the meninges, and when they do, these are mainly melanocytomas or melanomas. We describe the cytologic findings of atypical meningioma with intratumoral hemosiderin pigment mistaken for spindle cell melanoma in a 33-year-old male patient during intraoperative consultation. Preoperative radiologic images revealed a cystic meningeal mass ...
Feasel Patrick C PC Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, - - 2014
We report a case of a primary cutaneous epithelioid rhabdomyosarcoma that presented as a single raised pink-purple lesion (3.3 x 2.2 cm) on the left base of neck in a 75-year-old man. Histopathologic examination revealed an exophytic, nodular tumor within the dermis and superficial subcutis with overlying ulceration. The tumor exhibited ...
Wan Yang Y Department of Pathology, School of Medicine, Anhui University, Hefei, 230032, PR - - 2014
Osteoblastoma (OB) and osteosarcoma (OS) are 2 bone tumors that predominantly affect young adults. The clinical management of OS differs significantly from that of OB, and thus, accurate diagnosis of OB and OS is critical in determining appropriate treatment modality. However, in certain cases, OS significantly overlaps with OB in ...
Golbar H M HM Veterinary Pathology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-Ourai-Kita, Izumisano City, Osaka 598-8531, - - 2014
A 7-year-old mixed breed neutered female rabbit (Orytolagus cuniculus) developed a solitary black nodular mass (1 cm in diameter) in the skin of the right flank. Microscopically, the mass consisted of an admixture of neoplastic trichoblasts and melanocytes. The former were arranged as solid, trabecular, island-like and gland-like structures and the ...
D Manimaran M Associate Professor, Department of Pathology, Shri Sathya Sai Medical College and Research Institute , Tiruporur, Tamilnadu, India - - 2014
Background: Fine needle aspiration cytology (FNAC) is an important investigation in preoperative diagnosis of thyroid lesions. Follicular variant of papillary carcinoma thyroid (FVPTC) is a well defined entity in histopathology, but its diagnosis in FNAC is usually missed and is challenging compared to classic papillary thyroid carcinoma. Aims: The purpose ...
Wadhwa Neelam N Department of Pathology, University College of Medical Sciences, University of DELHI, - - 2014
Infarction is an uncommon event in a fibroadenoma, which is the commonest benign tumor of the breast. Most often it occurs in pregnancy, lactation or is secondary to fine needle aspiration. Spontaneous infarction of a fibroadenoma in the absence of a predisposing condition is very rare. The cytopathologic features of ...
Campione Elena E Department of Dermatology, University of Rome "Tor Vergata" Viale Oxford 81, IT-00133 Rome, Italy. - - 2014
The detoxifying enzyme glutathione-s-transferase pi (GST-π) is present in keratinocytes and melanocytes and exerts a protective role against tumour progression. Melanomas close to melanocytic naevus remnants occur less frequently on sun-exposed areas, whereas solar dermal elastosis, hallmark of chronic sun-damage, characterise melanomas on sun-exposed skin. We evaluated the expression of ...
Becker Clinic for Ruminants, Vetsuisse Faculty, University of Berne, - - 2014
Prevalences of foot lesions and lameness were recorded in 1'449 Swiss dairy cows during routine claw-trimming on 78 farms from June 2010 until February 2011. Lameness was present in 14.8 % of cows and on 80.8 % of investigated farms. Highest prevalences were seen for widened white line (80.7 %/100 ...
Lee Si-Hyung SH Department of Dermatology, Gangnam Severance Hospital, The Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, - - 2014
Elastosis perforans serpiginosa is a rare skin disease characterized by transepidermal elimination of abnormal elastic fibers. This condition classically presents as small papules arranged in serpiginous or annular patterns on the neck, face, arms, or other flexural areas. While these lesions may spontaneously resolve, they often persist for longer periods ...
Truskinovsky Alexander M AM *Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota (A.M.T.) †Department of Pathology, Tel Aviv Medical Center, Tel Aviv (B.L.-M) ‡Patho-Lab Diagnostics Ltd., (B.C.) Ness-Ziona, - - 2014
The diagnosis of endometrial hyperplasia or carcinoma in a background of secretory endometrium can be difficult. We attempt to establish the diagnostic criteria to be used in such cases. We examined 80 cases of endometrial hyperplasia, carcinoma, and other conditions with glandular crowding arising in secretory endometrium, analyzed their morphologic ...
Kumagai Y Y Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, - - 2014
Endocytoscopy (ECS) is a novel endoscopic technique that allows detailed diagnostic examination of the gastrointestinal tract at the cellular level. We previously reported that use of ECS at ×380 magnification (GIF-Y0002) allowed a pathologist to diagnose esophageal squamous cell carcinoma (ESCC) with high sensitivity (94.9%) but considerably low specificity (46.7%) ...
Lei Yu Y Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, USA. Electronic address: - - 2014
Ameloblastic carcinoma often poses diagnostic challenges in its separation from benign ameloblastoma with atypical cytologic features or an unusual clinical course. This study aimed to determine whether SOX2 (sex determining region-Y-related high mobility group box 2), a protein expressed in the epithelial basal proliferative zone in dentigerous cysts, is a ...
Cox Roni R Departments of *Pathology †Gynecology and Obstetrics ‡Urology §Oncology, The Johns Hopkins Hospital, Baltimore, - - 2014
Papillary cystadenoma is an uncommon epithelial tumor, originating within the head of the epididymis and broad ligament. When the lesion is bilateral, it is associated with von Hippel-Lindau disease. Its resemblance to metastatic clear cell renal cell carcinoma (RCC) has been noted in the literature. Owing to the emergence of ...
Larson Allison R AR 1] Program in Dermatopathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, - - 2014
DNA methylation is the most well-studied epigenetic modification in cancer biology. 5-hydroxymethylcytosine is an epigenetic mark that can be converted from 5-methylcytosine by the ten-eleven translocation gene family. We recently reported the loss of 5-hydroxymethylcytosine in melanoma compared with benign nevi and suggested that loss of this epigenetic marker is ...
Ordóñez Nelson G - - 2014
SATB2 is a nuclear matrix-associated transcription factor and epigenetic regulator that is involved in osteoblastic differentiation and is also expressed in the glandular epithelial cells of the lower gastrointestinal tract. Recent studies have shown that, because of its relative specificity for osteoblastic differentiation, SATB2 immunostaining could potentially be a useful ...
Wanjari Sangeeta Panjab SP Department of Oral & Maxillofacial Pathology, Modern Dental College & Research Centre, Indore, Madhya Pradesh, - - 2014
Papillary cystadenocarcinoma (PCC) is an uncommon malignant tumour of the salivary gland, sometimes involving the minor salivary gland. Previously this entity was classified as an atypical type of adenocarcinoma, malignant papillary cystadenoma, low-grade papillary adenocarcinoma or mucus producing adenopapillary carcinoma. PCC is a glandular tumour with an indolent biological behaviour ...
Evans Mark F MF Department of Pathology, University of Vermont, Burlington, Vermont, United States of - - 2014
Cervical lesion grading is critical for effective patient management. A three-tier classification (cervical intraepithelial neoplasia [CIN] grade 1, 2 or 3) based on H&E slide review is widely used. However, for reasons of considerable inter-observer variation in CIN grade assignment and for want of a biomarker validating a three-fold stratification, ...
Mihalache Daniela D Department of Morphofunctional Sciences, "Grigore T. Popa" University of Medicine and Pharmacy, Iassy, Romania; - - 2014
This study focuses on the analysis of geometric descriptors that can be applied in breast cytology, and their correlation with the qualitative features, with the aim to underline the differences between the benign and malignant cell profile. The morphometric investigation was performed on smears obtained by fine needle aspiration, 10 ...
Isomoto Hajime - - 2013
The gastric lesions of various lymphomas were observed at the cellular level using endocytoscopy. Endocytoscopy and magnifying endoscopy with crystal narrow band imaging (NBI) were performed in 17 patients with lymphomas of the stomach. The lesions consisted of 7 with low-grade mucosa-associated lymphoid tissue (MALT), 5 with gastric involvement by ...
Manivannan P P Departments of Pathology and Otorhinolaryngology, Jwaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, - - 2013
To identify the most useful cytomorphological features of follicular variant of papillary thyroid carcinoma (FVPTC). Fine needle aspiration cytological features of seven histologically proven FVPTCs were systematically evaluated in a blinded manner for various architectural, nuclear, cytoplasmic and background features with special reference to nuclear morphology. Most smears were moderate ...
Kuo C L - - 2013
Metastasis of nasopharyngeal carcinoma (NPC) to the dura is extremely rare. Dural metastasis of NPC can be symptomatically silent and also mistaken for a benign entity radiographically. Missed diagnosis can lead to serious consequences or prove immediately fatal for such patients. We report a woman with dural metastasis from the ...
Goyal Abha A Cleveland Clinic, Cleveland, - - 2013
Stratified mucin-producing intraepithelial lesion (SMILE) of the cervix is a human papilloma virus (HPV) associated high grade intraepithelial columnar cell neoplasm that is thought to arise from the reserve cells of the transformation zone. It is composed of immature stratified cells that display intracytoplasmic mucin and is commonly associated with ...
Ghazani Arezou - - 2013
Advances in nanotechnology and microfluidics are enabling the analysis of small amounts of human cells. We tested whether recently developed micro-nuclear magnetic resonance (μNMR) technology could be leveraged for diagnosing pulmonary malignancy using fine needle aspirate (FNA) of primary lesions and/or peripheral blood samples. We enrolled a cohort of 35 ...
Rodriguez Erika F - - 2013
Intraocular lymphoma may occur, primarily with or without overt parenchymal CNS lymphoma or secondarily from a variety of other lymphomas. The diagnosis is frequently based on cytologic features and/or a limited panel of ancillary techniques. Twenty-seven cytology samples from the vitreous preparations of 20 patients with clinical suspicion or histopathologic ...
Mooren Jeroen J - - 2013
Human papillomavirus (HPV) is a risk factor for the development of benign and malignant mucosal head and neck lesions. P16(INK4A) is often used as a surrogate marker for HPV-infection, although there is still controversy with respect its reliability. Our aim was to determine if p16(INK4A) overexpression can accurately predict both ...
Rodriguez Erika F - - 2013
Objective: The fallopian tube is now recognized as a primary source of precursor neoplastic lesions for pelvic serous adenocarcinomas. Cytologic features of fallopian tube brushings from low-risk patients have not been well described. Study Design: We describe the cytomorphology of tubal epithelium from prospectively collected experimental in vivo brushings from ...
Sreeshyla Huchanahalli S - - 2013
To evaluate the morphometry of AgNORs in odontogenic cysts and to compare their biologic behavior to determine whether AgNOR morphometry is helpful in predicting the behavior. Ten cases each of odontogenic keratocyst (OKC), dentigerous cyst (DC) and radicular cyst (RC) were stained with silver nitrate. Morphometric analysis of 100 selected ...
Rekhi Bharat B Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, - - 2013
Scar endometriosis can be a diagnostic challenge in fine-needle aspiration cytology (FNAC) smears that at times, is the first diagnostic modality in such cases. The challenge is amplified when the clinical details are limited and cytopathological features reveal nuclear atypia. A 33-year-old lady presented with an abdominal swelling that she ...
Rossi Esther D - - 2013
DESIGN THE CYTOLOGICAL DIAGNOSIS OF ONCOCYTIC/HURTHLE CELL NEOPLASMS (OCN) REPRESENTS A CHALLENGE WITH WHICH CYTOPATHOLOGISTS FACE UP TO IN THEIR PRACTICE. THE MAJORITY OF THESE LESIONS UNDERGO SURGERY FOR A DEFINITIVE CHARACTERIZATION OF THE NATURE MAINLY DUE TO THEIR MORE AGGRESSIVE BEHAVIOR THAN OTHER MALIGNANT FOLLICULAR LESIONS. WE AIM AT ...
Pitman Martha B - - 2013
The recognition of epithelial cells with high-grade atypia (HGA) in the cyst fluid of an intraductal papillary mucinous neoplasm (IPMN) identifies a cyst at high risk of invasive carcinoma. To the best of the authors' knowledge, the cytological features of HGA have not been systematically analyzed to define diagnostic criteria. ...
Niehusmann Pitt - - 2013
The distinction of isolated malformations and combined lesions constitutes a major novelty in the 2011 consensus classification of the International League against Epilepsy (ILAE) for focal cortical dysplasias (FCD). Cortical lamination abnormalities together with vascular lesions are subsumed as FCD IIIc. Little is known regarding frequency and etiology of this ...
Asioli Sofia - - 2013
Recent reports indicate that hobnail papillary thyroid carcinoma (HPTC) is a rare, but very aggressive variant of papillary thyroid carcinoma. The authors describe the cytological features of five HPTC on fine-needle aspiration biopsies (FNAB). Moreover, their immunophenotype and the presence of B-RAF mutation by pyrosequencing were investigated. The patients' (three ...
Walts Ann E - - 2013
Controversy exists regarding the validity of follicular lesion of undetermined significance (FLUS), an indeterminate diagnostic category of The Bethesda System for Reporting Thyroid Cytopathology (BSRTC). According to BSRTC, FLUS carries a 5-15% risk of cancer. This study was designed to determine if cytomorphology could stratify FLUS into subgroups with different ...
Hayashi Hiroko - - 2013
Intraductal/intracystic papillary carcinoma (IPC) of the breast is defined as a malignant non-invasive papillary tumor arising from the ductal-lobular system. Based on the presence of myoepithelial cells in the cystic wall, IPC is distinguished from encapsulated papillary carcinoma (EPC). Here, we report a case of an intracystic apocrine papillary tumor ...
Agnihotri Mona - - 2013
Objective: To put forth the cytological features and diagnostic pitfalls of spontaneously infarcted breast lesions on fine-needle aspiration cytology (FNAC). Study Design: We present 19 cases of spontaneously infarcted breast lesions encountered on FNAC over a 5-year period. Histological follow-up was correlated wherever available. Results: The majority of cases were ...
Dhingra S - - 2013
We report the case of a 20-year-old man with a constellation of anomalies - a functional thyroglossal cyst and concurrent ectopic thyroid in the floor of the mouth, without an orthotopic thyroid gland. To our knowledge, this is the third such report in the otolaryngology literature. It is important to ...
Trope Gareth D - - 2013
A 22-year-old Australian stockhorse gelding was presented with anterior uveitis in the right eye which was nonresponsive to anti-inflammatory therapy. Clinical examination revealed corneal edema and vascularization, marked hypopyon, and thickening of the dorsal iris, which was confirmed by ultrasonography. Hematologic and biochemical analyses, abdominal and thoracic ultrasonography, and abdominocentesis ...
McCluggage W Glenn - - 2013
Myogenin (myf4) is a nuclear transcription factor that is considered to be a sensitive and highly specific marker for skeletal muscle differentiation. Following the identification of focal strong nuclear staining with myogenin in two fibroepithelial polyps of the lower female genital tract (the index cases), we stained a series of ...
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