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Neligan A A National Hospital for Neurology and Neurosurgery, Queen Square, London, - - 2014
The diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is usually straightforward, but atypical presentations can represent a significant diagnostic challenge. This review highlights the clinical and electrophysiological 'red flags' that should make one consider an alternative diagnosis.
Modarres Mehdi - - 2014
Vitrectomy and endoresection is an alternative to enucleation for the treatment of large malignant choroidal melanoma. We report a rare case of extensive recurrence of choroidal malignant melanoma with extraocular extension 11 years after surgical endoresection without adjuvant treatment.
Wang Hailing H Department of Ultrasonographic Diagnosis and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, - - 2014
To assess the diagnostic value of elastosonography for thyroid microcarcinoma (TMC), particularly with regard to elasticity score (ES) and strain ratio (SR). Conventional ultrasound and elastosonography were performed for 487 thyroid micronodules before surgery. We set the histology as the reference standard. The ES and SR values, as well as ...
Havre Roald Flesland RF Department of Medicine, Haukeland University Hospital , Jonas Lies vei, Bergen , - - 2014
Abstract Objectives. The aim of this study was to evaluate the diagnostic potential of strain assessment in solid focal pancreatic lesions using real-time elastography in combination with endoscopic ultrasonography (EUS). Material and methods. Forty-eight solid focal pancreatic lesions in 39 patients were included prospectively over a 3-year period and studied ...
Kim Yoon Seok YS Department of Surgery, Kosin University Gospel Hospital, Busan, - - 2014
The aim of this study was to determine whether the combination of B-mode ultrasonography (BUS), acoustic radiation force impulse (ARFI) elastography, and strain ratio (SR) provides better diagnostic performance of breast lesion differentiation than BUS alone. ARFI elastography and SR evaluations were performed on patients with 157 breast lesions diagnosed ...
Waligórska-Stachura Joanna J Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, PoznaƄ, - - 2014
Thyroid cancer incidence has increased significantly during the past decades and is the most common type of endocrine malignancy. Many factors in thyroid cancers were studied as independent predictors of a poor prognosis. The objective of the study was to evaluate survivin expression - BIRC5 and its splice variants: survivin ...
Raper Daniel D Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, - - 2014
Stereotactic radiosurgery (SRS) has been well reported in the treatment of certain calcified intracranial lesions such as meningiomas. However, reduction in the calcified portion of the tumour after SRS treatment has not been reported. We present the case of a 76-year-old man with a right petroclival lesion consistent on imaging ...
Lencastre André A Centro Hospitalar de Lisboa Central, EPE, Hospital de Santo António dos Capuchos, Dermatology/Venereology Department, Lisbon, - - 2013
A 34-year-old woman with no known medical history was evaluated for multiple painful brown nodules and papules on the anterior aspect of the trunk. She mentioned a history of similar cutaneous findings on her mother. Biopsies of three lesions revealed piloleiomyomata. Renal and adrenal ultrasound revealed an isolated simple cortical ...
Nagy Gábor - - 2013
Despite increasing worldwide experience, the role of stereotactic radiosurgery (SRS) in the management of cerebral cavernous malformations (CMs) remains controversial. Microsurgical excision of easily accessible CMs is typically safe; therefore, removal remains the gold standard for most of the symptomatic hemispheric lesions. However, there is now sufficient evidence supporting the ...
Kang Christopher Y - - 2013
Type VI collagen (COL6) forms a microfibrillar network often associated with type I collagen and constitutes a major component of the desmoplastic reaction in pancreatic ductal adenocarcinoma (PDA). We have demonstrated recently that the α3 chain of COL6, COL6A3, is highly expressed in PDA tissue and undergoes tumor-specific alternative splicing. ...
Chen Chih-Ping - - 2013
To present a prenatal diagnosis of familial tuberous sclerosis complex (TSC). A 29-year-old woman was referred to our institution for amniocentesis at 24 weeks of gestation because of congenital anomaly. The fetus had been found to have an intrathoracic echogenic mass, suspicious of type III congenital cystic adenomatoid malformation of ...
Yuce Yucel Y Anaesthesiology and Reanimation Department, Faculty of Medicine, Hacettepe University, Ankara, Turkey. Electronic address: - - 2013
A 56-year-old man presented himself for an intracranial glioblastoma multiforme excision. After being routinely monitored, he was preoxygenated. We induced anesthesia and paralysis with 200mg propofol, 50μg fentanyl and 9mg vecuronium. Direct laryngoscopy with a Macintosh 3 blade revealed a 2x2cm cyst, pedunculated, arising from the right side of the ...
du Perron L J - - 2013
The majority of tumours in the pancreas are adenocarcinomas for which therapeutic options are limited and which are associated with an unsatisfactory prognosis. However, alternative diagnoses may result in other therapeutic approaches with often a more favourable outcome. Hence, it is crucial to obtain a histological diagnosis before a definitive ...
Gurzu Simona - - 2013
The Ena/VASP (enabled/vasodilator stimulated phosphoprotein) family includes the binding actin proteins such as mammalian Ena (Mena), VASP, and Ena-VASP-like. It is known that the perturbation of actin cycle could determine alteration in the mobility of cells and in consequence of organogenesis. Few recent studies have revealed that Mena protein could ...
Amichetti Maurizio - - 2012
ABSTRACT: Stereotactic radiosurgery (SRS) is an important treatment option for intracranial lesions. Many studies have shown the effectiveness of photon-SRS for the treatment of skull base (SB) tumours; however, limited data are available for proton-SRS.Several photon-SRS techniques, including Gamma Knife, modified linear accelerators (Linac) and CyberKnife, have been developed and ...
Sunohara Mari - - 2012
Epidermodysplasia verruciformis (EV) is a rare heritable skin disease that results in unusual susceptibility to infection with specific types of human papillomavirus (HPV). Here we report a 53-year-old man with EV who developed Bowen's disease on his lower eyelid and the chest. Mutation analysis of EVER1 gene revealed homozygous splice ...
de Waal Esther G M - - 2012
Osseous involvement defined by lytic bone lesions is shown by skeletal survey in multiple myeloma (MM). This technique has limitations because it detects only lesions with more than 30% trabecular bone loss. In addition, lesions persist after chemotherapy, thereby limiting its usefulness at relapsing disease. Alternative techniques to detect new ...
Figueiredo Fátima A F FA Unité d'Exploration Médico-Chirurgicale Oncologique, Institut Paoli-Calmettes, France ; Gastroenterology Department, University of the State of Rio de Janeiro and Federal University of Rio de Janeiro, - - 2012
Although endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) is the gold standard for diagnosing pancreatic lesions, its negative predictive value is suboptimal. Our aim was to evaluate the yield of contrast-enhanced EUS (CED-EUS) and of strain ratio EUS-elastography (SR-E-EUS) for differentiating pancreatic solid lesions. Forty-seven patients (27 men, 20 women, 70 ...
Lippert Frank - - 2012
This study investigated the effects of lesion baseline characteristics and different strontium (Sr) to calcium (Ca) ratios in plaque fluid-like solutions (PF) on lesion de- and remineralization. Caries lesions were formed in enamel using three protocols: methylcellulose acid gel (MeC) and partially saturated lactic acid solutions containing carboxymethylcellulose (CMC) or ...
Shiferaw Kebede - - 2012
ABSTRACT: We describe the sudden death of a 42-year-old white man. The decedent was a healthy young man with a short clinical history of chest pain, fatigue, dizziness, and pyrosis. Two weeks before his death, he underwent medical evaluation for the aforementioned symptoms. Electrocardiogram, chest x-ray, and serum troponin were ...
Talmon Geoffrey Allen - - 2012
Enumeration of crypt apoptotic bodies (AB) is used in the diagnosis of acute cellular rejection (ACR) in small bowel allografts. Due to differing definitions, there is a potential for variation in AB numbers between pathologists that may affect diagnosis. Thirty biopsies from allografts were obtained: 10 negative for ACR, 10 ...
Wang Hai-Ling - - 2012
Real-time ultrasound elastography (US-E) is a helpful tool in diagnosing thyroid nodules. This study aims to evaluate thyroid solid nodules, to establish the accuracy of US-E in providing information on the nature of these nodules, and to assess the clinical value of elasticity scores (ES) and strain ratio (SR) in ...
Klapper W - - 2012
Malignant lymphoma along with leukemias account for nearly half of all malignancies arising in childhood and adolescence. The correct tissue-based histopathological diagnosis of lymphomas results from a close interdisciplinary exchange between pediatric oncologists and hematopathologists. We describe here relevant features of lymphoma subtypes arising in the young age group, Burkitt ...
Jakobiec Frederick A - - 2012
An 86-year-old woman slowly developed a solitary 0.3 × 0.2-cm papule on the left lower eyelid. Complete excision disclosed a honeycombed lesion composed of interlacing basaloid strands unattached to the epidermis but rather extending into the dermis from a dilated hair follicle. The diagnosis was a solitary basaloid follicular hamartoma ...
McKenzie Jodi A - - 2012
Melanoma is the deadliest form of skin cancer. Melanoma develops in response to genetic and environmental pressures which lead to oncogenic transformation of normal human melanocytes, the pigment-producing cells in the body. The majority of melanoma-associated deaths are due to metastases, highlighting the importance of understanding the molecular mechanisms driving ...
Cantisani Vito - - 2012
Quantitative ultrasound (US) elastography (Q-USE), able to evaluate tissue stiffness has been indicated as a new diagnostic tool to differentiate benign from malignant thyroid lesions. Aim of this prospective study, conducted at the Department of Surgical Sciences, of the "Sapienza" University of Rome, was to evaluate the diagnostic accuracy of ...
Eliot Colin A - - 2012
A 25-year-old female presented with a well-defined, painless mass of 1 year's duration in the right parotid gland. MR imaging revealed a relatively well-circumscribed lesion involving the deep and superficial lobes of the right parotid gland. Histologic examination of the resection resulted in a diagnosis of sclerosing polycystic adenosis, a ...
Blanco Luis Z - - 2011
Sclerosing hemangioma of the lung is a rare benign neoplasm. The majority of the literature published on sclerosing hemangioma has focused on the histologic features, while only a few case reports have described the cytologic features. We report two additional cases of sclerosing hemangioma of the lung in which the ...
Agner Shannon C - - 2011
Dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) of the breast has emerged as an adjunct imaging tool to conventional X-ray mammography due to its high detection sensitivity. Despite the increasing use of breast DCE-MRI, specificity in distinguishing malignant from benign breast lesions is low, and interobserver variability in lesion classification is ...
Meunier Yann A YA Stanford Hospital & - - 2011
We present the case of a 32-year-old French man who presented with morning nausea, bloating, frequent flatulence, burping, occasional pyrosis, and alternating diarrhea and constipation two weeks after a trip to Morocco. The diagnosis was established by a parasitological stool exam that revealed cysts of Giardia lamblia. He was successfully ...
Urrechaga Eloísa - - 2011
Cell counter-based formulas have been used in the differential diagnosis of microcytic anemia. The measurement of RBC subpopulations is now available on the Sysmex XE 5000 analyzer (Sysmex, Kobe, Japan). We describe the new formulas: % microcytic - % hypochromic; and % microcytic - % hypochromic - red cell distribution ...
Yakut Mustafa - - 2011
OBJECTIVES:: Cameron lesions are located at the neck of large hiatal hernias, and are associated with anemia or overt gastrointestinal (GI) bleeding. The aim of this study was to investigate the clinical and endoscopic properties of patients with Cameron lesions. METHODS:: Eighteen patients were diagnosed as having large hiatal hernia ...
Kosemehmetoglu Kemal - - 2010
Papillary apocrine metaplasia (PAM) and columnar cell lesion with atypia (CCL) are considered as candidates of early premalignant breast lesions. In this study, we investigated their relationship at the morphological level, as we noticed their histologic coexistence and proximity in daily routine. We selected 93 neoplastic and nonneoplastic cases with ...
Shin Hee Jung - - 2010
The objective of our study was to retrospectively determine the positive predictive value of each descriptor and of combined descriptors for microcalcifications to predict the risk of malignancy as well as the appropriate final assessment category. A total of 308 needle-localized open breast biopsies for mammographically detected microcalcifications were performed ...
Ogiya Akiko A Department of Breast Surgery, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Suntou-gun, Shizuoka, 411-8777, Japan, - - 2014
IgG4-related sclerosing disease was first identified and defined in the twenty-first century. In this pathology, the serum IgG4 level increases and IgG4-positive plasma cells and lymphocytes infiltrate organs such as the pancreas, salivary glands, lacrimal glands, kidneys, and the retroperitoneum. Presented in this report is a case of IgG4-related sclerosing ...
Rodríguez-Gil Yolanda - - 2010
Metastatic neoplasms of the breast are rare. Mammary metastases as the initial presentation are even more infrequent and can simulate a primary malignancy clinically and radiologically. Recognition of metastatic tumors in the breast is important because it would prevent unnecessary mutilating surgery and would lead to appropriate treatment of the ...
Dietzel Matthias - - 2010
Necrosis sign (NS) is a new descriptor for differential diagnosis of breast lesions in magnetic resonance (MR)-mammography (MRM). This study was designed: (a) to analyze diagnostic accuracy of NS in 1,084 histologically verified breast lesions, (b) to assess performance of NS in subgroups. This study was approved by the local ...
Hong Su Jin - - 2010
Sparganosis is caused by the tapeworm larva of the geneus Spirometra. Because sparganosis usually manifests as a migrating subcutaneous mass, sonography can play an important role in its diagnosis. In this series, we investigated 4 cases of subcutaneous sparganosis and focused on the sonographic findings. Three of the cases involved ...
Rinaldi Pierluigi - - 2010
This article reviews basic sonographic findings for distinguishing cystic lesions of the breast. We describe sonographic features of simple and complicated cysts in comparison with complex masses and intracystic carcinomas. We correlate cystic lesion appearances with histologic patterns and illustrate the diagnostic and therapeutic management of cystic breast lesions. Sonography ...
Tea Muy-Kheng Maria - - 2011
Simple breast cysts are a common sonographic finding and do not require further diagnostic evaluation. In contrast, atypical breast cysts do harbour a risk of malignancy. The purpose of this study was to evaluate the predictive value of sonographic findings that are considered characteristic of malignant atypical cyst-like lesions. Six ...
Fornasa F - - 2011
This study assessed the usefulness of magnetic resonance diffusion-weighted imaging (DWI) in distinguishing between benign and malignant breast lesions. Gadolinium-enhanced magnetic resonance imaging (MRI) and DWI with determination of the apparent diffusion coefficient (ADC) were performed on 78 women, each with a focal breast lesion at least 7 mm in ...
Patel Mihir - - 2010
A 36-year-old woman was referred to our department for I-123 metaiodobenzylguanidine (MIBG)-SPECT/CT scan 3 years after surgical excision of pheochromocytoma. She was referred due to recurrence of her symptoms as well as raised urinary catecholamines. Review of I-123 MIBG scan revealed multiple MIBG-avid metastatic lesions. Most of these were bony ...
Bhalla Amarpreet - - 2010
Cytokeratin s (CK) are used for the fingerprinting of carcinomas in general. In breast tissue, the luminal epithelial cells express CK 8/18, CK 7 and CK 19, while basal/myoepithelial cells express CK 5/6, CK 14 and CK 17. Immunohistochemical staining for cytokeratin 5/6 was applied on cell block sections of ...
Pediconi Federica - - 2010
To prospectively determine the diagnostic performance of breast magnetic resonance (MR) imaging in predicting the malignancy of breast lesions classified as borderline at core needle biopsy (CNB). This prospective study was approved by the local ethics committee, and all patients provided written informed consent. Between February 2007 and October 2009, ...
Duval A - - 2011
Pyoderma gangrenosum (PG) is a non-infectious purulent ulcerative disease triggered mainly by chronic inflammatory bowel disease, monoclonal gammapathy, polyarthritis and haematological malignancies; exceptionally, it can be triggered by surgery alone. When PG is associated with fever, it can mimic infectious cellulitis. When it is located on the breast, unnecessary and ...
Roberts-Klein Shayna - - 2011
There is a public misconception that screening mammography detects all breast malignancies. The objective of this pictorial essay is to review classic mammographic features of malignancy that, if missed, could potentially result in malpractice litigation. By identifying radiologic themes, we attempt to improve awareness about the imaging characteristics of a ...
Dietzel M - - 2011
This study was conducted to investigate the appearance of breast lesions in MR mammography (MRM) as a function of size and to identify the potential impact on diagnostic accuracy. 936 histologically verified breast lesions (standardized MRM protocol; consecutive 12-year period at our institution, diameter 5 - 50 mm) were prospectively ...
Alcock Chris - - 2010
This study was a retrospective analysis of patients who underwent minor or major duct surgery for pathological nipple discharge. The results of clinical examination, mammography, ultrasonography and cytodiagnosis of the nipple discharge were studied in order to predict those patients at risk of underlying or occult malignancy. Between January 2004 ...
Berg Wendie A WA American Radiology Services Inc, Johns Hopkins Green Spring, 10755 Falls Road, Suite 440, Lutherville, MD 21093, USA. - - 2010
Masses due to cystic lesions of the breast are extremely common findings on mammography, ultrasonography, and magnetic resonance imaging. Although many of these lesions can be dismissed as benign simple cysts, requiring intervention only for symptomatic relief, complex cystic and solid masses require biopsy. Perhaps, the most challenging are complicated ...
Lee Ji Hye - - 2010
The purpose of this study was to evaluate the ultrasonographic features of benign adenomyoepithelioma of the breast. Between 2005 and 2009, five patients had histologically confirmed adenomyoepithelioma of the breast. We retrospectively evaluated the ultrasonographic findings of the tumors in correlation with the pathology, and reviewed medical records. The clinical ...
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