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Henderson Samuel A SA *Department of Pathology, Section of Dermatopathology †Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, - - 2014
Poorly differentiated, cytologically malignant, spindle cell neoplasms of the skin may present a diagnostic challenge with important clinical consequences. In particular, the distinction between poorly differentiated cutaneous spindle cell squamous cell carcinoma (SpSCC) and atypical fibroxanthoma (AFX) remains controversial, but with important clinical implications: SpSCC exhibits an increased tendency for ...
Kim Younghye Y Department of Pathology, Korea University Ansan Hospital, Ansan-Si, Gyeonggi, Republic of - - 2014
Abnormal expression of the spindle assembly checkpoint proteins causes tumor cell aneuploidy, which has been reported in various malignancies. The expression of mitotic arrest deficient 2 (MAD2) and cell-division cycle 20 homolog (CDC20), the key spindle assembly checkpoint proteins, has not been studied in cervical carcinogenesis. In this study, we ...
Adeleye Amanda J AJ Departments of 1Obstetrics and Gynecology and 2Pathology, and 3Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, - - 2014
Primary vulvar sarcomas are rare lesions of the lower genital tract. We report the case of a patient with a spindle cell sarcoma of the vulva. A 44-year-old woman presented with a painless vulvar mass. Vulvar biopsy demonstrated a spindle cell sarcoma with myofibroblastic differentiation. Pretreatment evaluation revealed no evidence ...
Philp Lauren L *Department of Plastic Surgery, University of Toronto, Toronto, Ontario, Canada; and †Department of Laboratory Medicine and Pathobiology, University of Toronto and University Health Network, Toronto, Ontario, - - 2014
: We report an unusual case of a fibrolipomatous hamartoma that arose in a nuchal nerve. Typically, fibrolipomatous hamartoma, otherwise known as a neural fibrolipoma or lipomatosis of nerve, arises in the median nerve, brachial plexus, cranial nerves, or plantar nerves. The differential diagnosis is broad and includes benign and ...
Higashino Takuya T From the Department of Plastic Surgery, Asahi General Hospital, Asahi City, Chiba, - - 2014
A spindle cell hemangioendothelioma is a relatively uncommon lesion, especially on the head and neck. Recurrence occurs after local excision of 50% to 60% of these lesions; therefore, it is important to recognize this unusual neoplasm and avoid misdiagnosis. Here, we report a rare case of a spindle cell hemangioendothelioma ...
Hang Jen-Fan JF Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, 11217, Taipei, Taiwan, Republic of - - 2014
Here we report a case of type A thymoma with adenoid cystic pattern, which extended to the lower anterior neck and clinically mimicked a nontoxic thyroid goiter. The cytologic smears of fine-needle aspiration showed cohesive fragments of short spindle cells with finely granular chromatin and inconspicuous nucleoli. Scant interspersed lymphocytes ...
Winter Andrea A George Washington University School of Medicine and Health Sciences; - - 2014
Spindle cell hemangioendothelioma is a rare benign vascular tumor that is not known to involve the sacrum. The authors describe the case of a 31-year-old woman presenting with low-back and radicular pain without weakness or bowel or bladder dysfunction. Admission CT and MRI studies revealed a large S1-3 lytic sacral ...
Narick Christina C Department of Pathology and Laboratory Medicine, Allegheny General Hospital, Pittsburgh, - - 2014
Myoepitheliomas are rare neoplasms that are typically found in the major and minor salivary glands and represent approximately 1.5% of all salivary gland neoplasms. We present a patient with an exophytic anterior midline neck mass, which was initially believed to be a thyroid isthmus nodule that underwent fine needle aspiration ...
Girhotra Manish M a Chacha Nehru Bal Chikitsalaya, - - 2014
Abstract Primary spindle cell lesions of lymph nodes, with the exception of Kaposi's sarcoma, are rare. Intranodal palisaded myofibroblastoma has been described as a spindle cell tumor with prominent amianthoid fibers, intralesional hemorrhage and intracellular or extracellular inclusions. Another spindle cell lesion, intranodal leiomyoma, has been reported only occasionally till ...
Jin Ming M Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, - - 2014
Endometrial stromal sarcoma (ESS) is an uncommon uterine neoplasm, but its occurrence as an extra-uterine primary (EESS) is exceedingly unusual, and the fine-needle aspiration (FNA) cytopathology of EESS is rarely described. We hereby present 2 women with primary gastric EESS whereby the FNA cytopathology of this rare entity showed a ...
Kim Jin Pyeong JP Department of Otolaryngology, Gyeongsang National University College of Medicine, Jinju, Korea. ; Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju, - - 2014
Atypical fibroxanthoma is a pleomorphic spindle cell tumor of the dermis and it's been known to be a benign lesion clinically in spite of malignant histologic features. But recurrence is estimated at between 2%-20% and metastasis has been reported. We are about to describe a 70-year-old man with the lesion ...
Tanvir Imrana - - 2014
Spindle cell lesions of thyroid are uncommon. Meningioma like tumour of thyroid is a rare variant of follicular adenoma, which can easily be misdiagnosed. One such case is being reported here with detailed histological, histochemical and immunohistochemical findings.
Yamashita Daisuke D Department of Clinical Pathology, Kobe City Medical Center General Hospital, Kobe, - - 2014
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, and typically present as discrete well-circumscribed but non-encapsulated tumor masses. In this report, we describe a case of colonic perforation caused by an unusual form of GIST. A 72-year-old Japanese woman presented to the emergency department ...
Botelho Luciane Francisca Fernandes LF Federal University of Sao Paulo, Department of Dermatology, Sao PauloSP, Brazil, Masters student, Department of Dermatology, Federal University of Sao Paulo (UNIFESP) - Sao Paulo (SP), - - 2014
Seborrheic keratosis is a common skin lesion which may coincidentally be associated melanocytic nevi. The authors describe a case of dysplastic nevus associated with seborrheic keratosis and discuss the clinical, dermoscopic, and histological findings of this association. They also discuss the association between seborrheic keratosis and other benign and malignant ...
Grillo E E Ramon y Cajal University Hospital. University of Alcala.. - - 2014
An 11-month-old girl presented with an erythematous nodule on the chest, which had been growing for 8 months. The tumor was composed of uniform polygonal and spindle-shaped cells, forming nodules and fascicles. The diagnosis of neurothekeoma was based upon the histology and immunohistochemistry.
Yamanishi Takahiro T Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, - - 2014
We encountered a patient with primary cervical leiomyoma with remarkable calcification and ossification. A 68-year-old man presenting with induration and swelling of the left submandibular region was found to have nodular lesions with calcifications in the left submandibular region and the upper mediastinum on CT. Fine needle aspiration biopsies (FNAB) ...
Lawson Victoria H VH Division of Neuromuscular Disorders, Department of Neurology, Wexner Medical Center at The Ohio State University, Columbus, Ohio, - - 2014
Multifocal motor neuropathy (MMN) is an uncommon, purely motor neuropathy associated with asymmetric deficits with predilection for upper limb involvement. Even in the early descriptions of MMN, the associations of anti-GM1 antibodies and robust response to immunomodulatory treatment were recognized. These features highlight the likelihood of an underlying autoimmune etiology ...
Corrado Stefania S Institute of Pathology, University of Modena and Reggio Emilia, Modena, - - 2013
Spindle cell transformation or metaplasia has been so far demonstrated in the context of both benign and malignant conditions. Spindle cell lesions of the thyroid gland of either primary or secondary origin to metastatic disease represent rare entities. We describe two patients with papillary thyroid carcinoma (PTC) showing spindle cell ...
Horner Liana - - 2013
Acute ulnar neuropathy at the wrist can be difficult to diagnose, as it is an uncommon neuropathy with variable clinical presentations and numerous etiologies. We present a case of acute ulnar neuropathy of the deep motor branch caused by a ganglion cyst in Guyon's canal. Interestingly, this case of acute ...
Hattab Eyas M - - 2013
Cranial fasciitis is a rare lesion of young children characterized by proliferation of fibroblastic spindle cells. Most are scalp masses and are only rarely intracranial, where an association with radiation therapy is exceptional. We report a 32-month-old toddler with a facial rhabdomyosarcoma, diagnosed at 3 months of age, and treated ...
Rutt Amy L - - 2013
Spindle cell carcinoma (SPCC) is a rare, malignant variant of squamous cell carcinoma (SCC), which shows biphasic proliferation of the conventional SCC component and malignant spindle shape cells with sarcomatous appearance. We present two cases of SPCC of the true vocal fold that presented as a benign appearing subepithelial mass. ...
Rahmani Mahboubeh - - 2013
Inflammatory pseudotumors have a diverse etiology, mycobacterial pseudotumor (MP) being one of them. MP is a rare entity; it has been reported infrequently in various organs and is extremely rare in the skin. We report a cutaneous MP in an immunosuppressed liver transplant recipient. The lesion consisted mostly of spindle ...
Mohindra Sandeep - - 2013
Next to multiple myeloma, osteosarcoma is the commonest primary malignant neoplasm of skeletal system. These are aggressive tumours, composed of spindle cells producing osteoid and rarely occur in calvaria. The authors report a 55-year-male harbouring clival osteosarcoma, his clinical presentation, radiological findings, management and outcome.
Walia Ritika - - 2013
Objectives: Fine-needle aspiration cytology serves as a rapid and cost-effective tool for the diagnosis of melanoma, especially in the recurrent and metastatic cases. The diagnosis poses a challenge due to the varied morphological patterns. Spindle cell melanoma mimics other sarcomas and carcinomas on morphology. This study highlights the cytomorphological features ...
Ramamurti Anjana A Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra University, Chennai, Tamil Nadu, - - 2013
Of the many neoplasms known, squamous cell carcinoma (SCC) is the most common to affect the oral cavity. Spindle cell carcinoma (SpCC) is considered a rare high malignant variant of SCC occurring predominantly in the upper aerodigestive tract. Soft-tissue spindle cell neoplasms are quite uncommon in the oral cavity reportedly ...
Shaaban Abeer M - - 2013
Fibroepithelial stromal polyps (FESP) are benign lesions that typically occur in the genital area and are known to represent a diagnostic challenge for pathologists. Not only do they have a spectrum of morphological changes that ranges from bland morphology to rather atypical appearances, but they also share morphological features with ...
Ma Ming M Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, - - 2013
Kidney cysts occur following inactivation of polycystins in otherwise intact cilia or following complete removal of cilia by inactivation of intraflagellar transport-related proteins. We investigated the mechanisms of cyst formation in these two distinct processes by combining conditional inactivation of polycystins with concomitant ablation of cilia in developing and adult ...
Bali Akshay - - 2013
Primary cutaneous leiomyosarcoma (PCL) is an exceedingly uncommon malignant superficial soft tissue sarcoma with a predilection for middle-aged to elderly male. Morphologic differential diagnosis includes a host of other malignant spindle cell neoplasms, thereby necessitating the use of a panel of immunohistochemical markers to arrive at a definitive diagnosis. We ...
Demirci Hakan - - 2013
A 77-year-old woman presented with a 3-month history of a lesion on her left lower eyelid. External examination showed a tan-colored nodule with an overlying crust-covered ulcer on the left lower eyelid, nasally. The ulcer measured 12 mm × 7 mm. Complete surgical excision with a frozen section margin control ...
Li Xiao-Man - - 2013
Epithelioid hemangioendothelioma is a relatively uncommon lesion usually presenting in soft tissues. The occurrence in the mediastinum is exceptional rare. Histologically, this tumor is characterized by epithelioid cells with intracytoplasmic vacuole s in a hyalinized or mucinous stroma. Occasionally, spindle cells or osteoclast-like giant cel ls can be observed. Herein, ...
Agrawal Ranjan - - 2013
Primary ovarian leiomyoma is a rare benign tumour of the ovary, which is seen in women who are aged between 20 years to 65 years. Ovarian leiomyomas can be confused with other spindle cell tumours which display gross anatomical and histological similarities. A case of a primary leiomyoma of the ...
Christou Elizabeth M - - 2013
Proliferative nodules (PN) are benign lesions that arise in large congenital melanocytic naevi (LCMN). Clinically and histologically they can be difficult to differentiate from malignancies, which are also associated with LCMN. The PN in this case consisted of undifferentiated spindle cells and exhibited unusual histological features including negative stains for ...
Miyauchi Chie - - 2013
Orbit, a Drosophila ortholog of microtubule plus-end enriched protein CLASP, plays an important role in many developmental processes involved in microtubule dynamics. Previous studies have shown that Orbit is required for asymmetric stem cell division and cystocyte divisions in germline cysts and for the development of microtubule networks that interconnect ...
Shah Kaushal Mahendra - - 2013
Most typical dentigerous cysts are commonly seen in association with third molars and maxillary canines. Only 5-6% of dentigerous cysts are associated with supernumerary teeth. We report a rare case of dentigerous cyst associated with an impacted anterior maxillary supernumerary tooth. The patient was treated surgically by enucleation of the ...
Loy Clement T - - 2013
While there has been a guideline for laboratory/genetic diagnosis of Huntington Disease (HD) since 1998, no such statement exists for the diagnosis of clinical HD. Informally, the most frequently used criteria for diagnosis of clinical HD is 'Motor 4' within the Unified Huntington Disease Rating Scale '99 (motor), made when ...
Agarwal S - - 2013
Spindle cell lipoma is a relatively uncommon benign adipocytic tumor that usually presents in subcutaneous fat of adult men. These are a rare form of lipoma, accounting for 1.5% of all lipomatous tumors, with a low rate of local recurrence and no risk of malignant behavior/dedifferentiation. Although few studies addressing ...
D'Antonio Antonio - - 2013
We herein report a rare case of pleomorphic lipoma of the tongue with a review of world literature. A 44-year-old woman presented with a nodule of the tongue that had been present for over three years. Clinical examination revealed a yellowish sub-mucosal lesion, measuring 3 cm in maximum diameter, protruding ...
Baderca Flavia - - 2013
The blue nevus is a variant of a melanocytic nevus that presents as blue-gray to blue or black papules or nodules measuring up to 1 cm in diameter; it has a predilection for females and can be congenital or acquired. The classification of blue nevi is complex, with biological behavior ...
Said Gérard - - 2013
Chronic inflammatory demyelinative polyneuropathy (CIDP) is an acquired polyneuropathy presumably of immunological origin. It is characterized by a progressive or a relapsing course with predominant motor deficit. The diagnosis rests on the association of non-length-dependent predominantly motor deficit following a progressive or a relapsing course associated with increased CSF protein ...
Biglan Kevin M - - 2013
Participants with the gene expansion for Huntington disease (HD) but not yet diagnosed were evaluated annually. Unidimensional diagnosis (UD) was a motor diagnosis defined as a diagnostic confidence level (DCL) of 4 (unequivocal motor signs, ≥99% confidence) on the standardized motor exam of the Unified Huntington Disease Rating Scale (UHDRS). ...
Pardhe Nilesh - - 2013
Spindle cell lipomas (SCLs) are a group of benign lipogenic tumours, typically arising in the posterior neck, upper back and shoulder of elderly male patients. Approximately 80% of these tumours arise in characteristic location, but 20% arise in unusual locations, thereby making these cases more difficult to diagnose. We present ...
Abd El Hafez Amal - - 2013
Metaplastic breast carcinoma (MBC) is a rare malignancy comprised of ductal, squamous and/or mesenchymal elements with problematic diagnosis. This study analyses MBC identifying its cytologic and histologic features and emphasizing the combined role of FNAC, histopathology and immunohistochemistry (IHC) in its diagnosis. Cytology and histopathology files search yielded 21 cases ...
Toriyama Ayano - - 2013
Leiomyomatosis peritonealis disseminata (LPD) is an extremely rare condition, which is characterized by the presence of multiple peritoneal and subperitoneal nodules composed of bland smooth muscle cells. Albeit extremely rare, coexistence of endometriosis within LPD lesions has also reported. Herein, we report the seventh documented case of LPD coexisting with ...
Giri Prithvi P Department of Neurology, CSM (King George's Medical University) Medical University, Lucknow, Uttar Pradesh, - - 2013
Solitary cysticercus granuloma (SCG) is the most common form of neurocysticercosis in India and usually presents with seizures. Pure motor monoparesis (PMM) due to cerebral cysticercus lesions has been rarely reported and it has not been seen with SCG. We describe a young girl with SCG who presented with PMM ...
Santos-Briz Angel - - 2012
ABSTRACT:: Perineuriomas are benign neoplasms composed of perineurial cells. Classically, perineuriomas are divided into 2 distinct clinicopathologic entities, known as intraneural and extraneural perineuriomas. Intraneural perineuriomas, first described as interstitial hypertrophic neuritis, involve the major nerve trunks, causing motor or sensory deficits. Here, we report a case of a 42-year-old ...
Flanagan Eoin P - - 2012
Introduction: Paraneoplastic lower motor neuronopathies have been reported rarely with Hodgkin lymphoma. Methods: We report a case of rapidly progressive motor neuronopathy preceding the diagnosis of Hodgkin lymphoma. Results: A 31-year-old woman developed subacute rapidly progressive quadriparesis. Electrodiagnostic studies revealed a severe diffuse disorder of motor neurons and their axons. ...
Mentrikoski Mark - - 2012
Abstract Spindle cell rhabdomyosarcoma is an uncommon subtype of embryonal rhabdomyosarcoma. Found almost exclusively in children, these tumors are classically located in the paratesticular and head and neck regions. Morphologically these lesions can resemble several other benign or malignant soft tissue spindle cell lesions especially smooth muscle or myofibroblastic tumors, ...
Anforth R M RM Department of Dermatology, Westmead Hospital, Westmead, NSW 2145, Australia. - - 2012
Inhibitors of mutant BRAF are emerging as standard of care in patients with metastatic melanoma carrying relevant oncogenic mutations. Cutaneous reactions are frequent and significant. We conducted a systematic prospective dermatological review of all patients enrolled at a single institution in the phase I/II clinical trial of the mutant BRAF ...
Sajid M S - - 2012
We report a case of pathological splenic rupture as a manifestation of malignant metastatic spindle cell tumour. To the best of our knowledge, this is the first case report of an atraumatic-pathological rupture of the spleen secondary to metastatic malignant spindle cell tumour. A 63-year-old man with a previous history ...
Thejaswini Mu - - 2012
A 30-year-old woman presented with a huge exophytic lobulated mass in the right breast, clinically and radiologically resembling phylloides tumor. Fine needle aspiration cytology smears showed clusters and singly scattered spindle cells along with structures reminiscent of verocay bodies. However, the epithelial elements were absent. A cytological diagnosis of benign ...
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