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Do Richard K G RK 1 Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY - - 2014
OBJECTIVE. The purpose of this retrospective study was to measure interobserver agreement in the assessment of malignant imaging features of intraductal papillary mucinous neoplasms (IPMNs) on MDCT. MATERIALS AND METHODS. Pancreatic protocol CT studies were reviewed for 84 patients with resected IPMNs. Maximal diameter of the dominant cyst, presence of ...
Al-Jiffry Bilal O - - 2014
Microcystic adenoma or serous cystadenoma (SCA) is an uncommon tumor type, accounting for only 1-2% of pancreatic exocrine neoplasms. Usually unifocal, SCAs present as single, large, well-demarcated, multiloculated, cystic tumors, 1-25 cm in size. A 73-year-old man initially presented with epigastric abdominal pain and was diagnosed with SCA involving the ...
Napoléon Bertrand B Department of Gastroenterology, Hôpital privé Jean Mermoz, Générale de Santé, Lyon, - - 2014
Background and study aims: The differential diagnosis of solitary pancreatic cystic lesions is frequently difficult. Needle-based confocal laser endomicroscopy (nCLE) performed during endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a new technology enabling real-time imaging of the internal structure of such cysts. The aim of this pilot study was to identify ...
Unal Betül B Akdeniz University, Antalya, Turkey - - 2014
Here, we present the case of a 31-year-old woman patient who underwent distal pancreatectomy with the history of gastric bypass surgery for obesity. The final histopathological diagnosis of the lesion was nesidioblastosis. Nesidioblastosis is the most common cause of organic persistent hyperinsulinemic hypoglycemia in newborns; however, it is rare in ...
Al-Haddad Mohammad A MA Department of Medicine, Indiana University, Indianapolis, Indiana, - - 2014
Background and study aims: Current diagnostic testing is inadequate to determine the malignant potential of pancreatic cysts, resulting in overcautious patient management. Integrated molecular pathology (IMP) testing combines molecular analysis with first-line test results (cytology, imaging, and fluid chemistry) to assess the malignant potential of pancreatic cysts. This multicenter study ...
Johnson Adam A Department of Microbiology, Immunology and Pathology, Vanderbilt University Medical Center, Nashville, TN, - - 2014
Recently, we described a series of pancreatic neuroendocrine tumours (PanNETs) featuring prominent stromal fibrosis, which we called sclerosing PanNETs. The aim of this study was to examine the pathological, immunophenotypic and clinical differences between sclerosing and non-sclerosing PanNETs. One hundred and six PanNETs were identified, of which 15 (14%) were ...
Fabbri Carlo C Unit of Gastroenterology and Digestive Endoscopy, AUSL Bologna Bellaria-Maggiore Hospital, Via Altura, 40139, Bologna, Italy, - - 2014
Early detection of small pancreatic cancer is important because expected survival is markedly better for tumors ≤2 cm. A new endoscopic ultrasound-(EUS) guided biopsy needle with side fenestration has been recently developed to enable fine-needle biopsy (FNB) under EUS guidance. The aim of this study was to evaluate the outcome of ...
Ashkar M M Department of Medicine, St. Elizabeth's Medical Center, Brighton, MA - - - 2014
Since its introduction, Endoscopic Ultrasonography (EUS) has been increasingly gaining more attention for diagnosing various gastrointestinal conditions. We aim to systematically review the literature and highlight the benefit of using EUS in different pancreatic diseases by primarily reviewing its importance in diagnosing, treating pancreatic pathologies, comparing its accuracy to other ...
Wang Jin J Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, - - 2014
Intraductal papillary mucinous neoplasm (IPMN) is a precursor cystic lesion to pancreatic cancer. With the goal of classifying IPMN cases by risk of progression to pancreatic cancer, we undertook an exploratory Next Generation Sequencing (NGS) based profiling study of miRNAs (miRNome) in the cyst fluids from low grade- benign and ...
Nakanuma Yasuni Y Department of Pathology, Shizuoka Cancer Center, Shizuoka, - - 2014
The biliary tract and pancreas develop from the foregut at almost same time, and the morphology of the biliary tract and pancreatic ducts share several features. In addition, there are peribiliary glands around the biliary tract, which occasionally contain pancreatic acini and enzymes. Some pancreatic and biliary tract diseases share ...
Jang Kee-Taek KT Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, - - 2014
The pathologic description for neoplastic polyps of the gallbladder (GB) was controversial. Although current WHO suggest adenoma and papillary neoplasm for precursor lesions, the distinction is not clear. In recent study for 123 GB cases, we found tumoral preinvasive neoplasms (≥1 cm) were analogous to their pancreatic and biliary counterparts. They ...
Yau Wilson W Department of Pathology, College of Veterinary Medicine, The University of Georgia, Athens, - - 2014
A 13-year-old female Boer goat with a history of chronic arthritis and recurrent episodes of recumbency, increased serum gamma-glutamyl transferase, and complete inability to stand was submitted for necropsy. Gross changes included the presence of a white, firm, smooth, 6 cm × 4 cm × 3 cm mass that diffusely ...
Jung Hae Il HI Hae Il Jung, Taesung Ahn, Myoung Won Son, Sang Ho Bae, Moon Soo Lee, Chang Ho Kim, Department of Surgery, Soonchunhyang University Cheonan Hospital, Cheonan 330-721, South - - 2014
Cystic lymphangiomas of the adrenal gland are rare. A 79-year-old female presented in the emergency room with epigastric discomfort, and an immovable mass was palpated in her abdomen upon physical examination. Imaging studies revealed a large cystic lesion in the pancreatic tail. The radiologic impression ruled out the possibility of ...
Kim John J JJ Division of Gastroenterology, Loma Linda University Medical Center, 11234 Anderson Street, Room 1556, Loma Linda, CA, 92354, USA, - - 2014
In jaundiced patients with suspected pancreatic cancer, endoscopic retrograde cholangiopancreatography (ERCP) with biliary stent is frequently performed prior to histologic diagnosis by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). To compare the accuracy of jaundiced patients undergoing EUS-FNA for a pancreatic mass with or without a biliary stent. Consecutive patients with a ...
Chang Xiaoyan - - 2014
BackgroundIntraductal tubular adenoma of the pancreas, pyloric gland type (ITA), is an infrequent intraductal benign lesion located in the main duct and large branch duct of the pancreas. The purpose of this report is to introduce seven new cases and to compare their clinicopathologic features and KRAS mutations to gastric-type ...
Ramesh Jayapal J From the *Division of Gastroenterology and Hepatology and †Department of Pathology, University of Alabama at Birmingham, Birmingham, AL; and ‡Center for Interventional Endoscopy, Florida Hospital, Orlando, - - 2014
Although a large gauge needle can procure more tissue at endoscopic ultrasound-guided fine needle aspiration (EUS-FNA), its advantage over smaller needles is unclear. This study compared flexible 19G and 25G needles for EUS-FNA of solid pancreatic masses. This was a randomized trial of patients undergoing EUS-FNA of pancreatic masses using ...
D'Onofrio M - - 2014
Purpose: To evaluate CEUS for the diagnosis of pancreatic diseases and its application in the clinical routine with a focus on the value of CEUS in ductal pancreatic carcinoma and its use for the differentiation of neoplastic and non-neoplastic lesions. Materials and Methods: All prospective and retrospective studies published in ...
Castellano-Megías Víctor M VM Víctor M Castellano-Megías, Department of Pathology, Hospital Universitario de Fuenlabrada, 28942 Fuenlabrada, Madrid, - - 2014
Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a noninvasive epithelial neoplasm of mucin-producing cells arising in the main duct (MD) and/or branch ducts (BD) of the pancreas. Involved ducts are dilated and filled with neoplastic papillae and mucus in variable intensity. IPMN lacks ovarian-type stroma, unlike mucinous cystic ...
Antonini Filippo F Department of Gastroenterology, A.Murri Hospital, Polytechnic University of Marche, Fermo, Italy. Electronic address: - - 2014
An asymptomatic 55-year-old woman with no significant past medical history was referred for a incidental detection of a small pancreatic mass. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of the pancreatic lesion was performed with a 25-gauge ProCore needle (Cook Endoscopy, Winston Salem, NC) to obtain a tissue diagnosis. Histology of the ...
Unno Jun J Division of Gastroenterology, Tohoku University Graduate School of Medicine , Sendai , - - 2014
Abstract Background. We assessed the controversial topic of using 22-gauge needles in endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis and evaluation of Ki67 labeling indices (Ki67LI) of pancreatic neuroendocrine tumors (pNET). Methods. Thirty-eight patients with pNET who underwent EUS-FNA between January 1, 2008 and December 31, 2012 were ...
Bang Ji Young JY Center for Interventional Endoscopy, Florida Hospital, Orlando, FL, - - 2014
When performing endoscopic ultrasound-guided fine needle aspiration (EUS-FNA), identifying neoplasia in the setting of chronic pancreatitis can be technically challenging. The morphology of an ill-defined mass on sonography, presence of calcifications or intervening collaterals, reverberation from a biliary stent, low yield of tissue procurement, and interpretative errors in cytopathology can ...
Lee Seong Jun SJ Department of Internal Medicine, Pusan National University School of Medicine, Busan, - - 2014
Ectopic pancreas is a congenital anomaly and the most common type of ectopic tissue in the gastrointestinal tract. Most patients with an ectopic pancreas are asymptomatic and rarely have complications. Ectopic pancreatitis after an endoscopic biopsy has not been reported. We report a patient who developed acute ectopic pancreatitis in ...
Virgilio Edoardo E Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology "Sapienza", St. Andrea Hospital, via di Grottarossa 1035-39, Rome 00189, Italy. Electronic address: - - 2014
Solid-pseudopapillary neoplasms (SPNs) of the pancreas are infrequent tumors since, as of 2014, only 2744 patients have been described. Its rarity, unclear histogenesis, pleomorphic aspect on radiology (cystic, solid or mixed) and unpredictable biological behavior with an insidious high-grade malignant potential make SPN difficult to recognize preoperatively even in its ...
Kitchens William H WH Department of Surgery, Massachusetts General Hospital, ACC 366 15 Parkman St., Boston, MA, 02114, - - 2014
A case of pancreatitis secondary to a hepatic hydatid cyst is illustrated together with its preoperative imaging and intraoperative appearance. Cystobiliary communication is a common complication of large hydatid cysts, and episodes of recurrent pancreatitis resulting from passage of cyst contents down the biliary tract are rarely described. The clinical ...
Bournet Barbara B Barbara Bournet, Louis Buscail, Department of Gastroenterology, CHU Toulouse Rangueil, University of Toulouse, 31059 Toulouse, - - 2014
Pancreatic ductal adenocarcinoma remains one of the most deadly types of tumor. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a safe, cost-effective, and accurate technique for evaluating and staging pancreatic tumors. However, EUS-FNA may be inconclusive or doubtful in up to 20% of cases. This review underlines the clinical interest of ...
Iacono Calogero C Department of Surgery, Division of General Surgery A, Unit of Hepato-Pancreatico-Biliary-Surgery, University of Verona Medical School, Verona, Italy. Electronic address: - - 2014
Head dorsal pancreatectomy (HDP) is a segmental pancreatic resection, conservative variant of total dorsal pancreatectomy, applied to preserve the functional pancreatic parenchyma as an alternative to pancreaticoduodenectomy in not enucleable benign or low-grade malignant lesions. The absences of biliary and gastrointestinal resection/reconstruction are the other advantages of the technique. We ...
Ali Sadaf S Department of Surgical GE, SKIMS, Soura, Srinagar, Jammu and Kashmir, - - 2014
Cystic tumors of the pancreas are rare and can be confused with hydatid cyst especially in endemic areas like ours. We present a 30-year-old woman with a huge mucinous cystadenoma of the pancreas initially diagnosed and prepared on table as hydatid cyst. After incising the cyst the diagnosis of cystic ...
Limaiem Faten F Department of Pathology, Mongi Slim Hospital, Université de Tunis El Manar, Faculté de Médecine de Tunis, La Marsa, - - 2014
Cystic neoplasms of the pancreas are rare and constitute approximately 0.5% of all pancreatic neoplasms. The study was to describe clinicopathological features of pancreatic cystic tumors. In our retrospective study, we reviewed 10 cases of pancreatic cystic neoplasms that were diagnosed at the pathology department of Mongi Slim hospital over ...
Foo Wai Chin WC Department of Pathology, M.D. Anderson Cancer Center , Houston, TX, - - 2014
We describe a 40-year-old man who was found to have a cystic mass in the pancreatic tail during workup for weight loss and abdominal discomfort. Although computed tomography scan showed a single cyst associated with dilatation of the main pancreatic duct, gross and histologic examination of the distal pancreatectomy specimen ...
Gargaglia Eleonora - - 2014
Pancreatic masses causing acute obstructive jaundice still pose diagnostic difficulties and their characterization can often be complex as there is significant overlap in their imaging features. We describe a case of Intraductal Papillary Mucinous Tumor (IPMT) presenting with acute obstructive jaundice in a patient with history of recurrent mild pancreatitis. ...
Rossi Roberta Elisa - - 2014
Aims and background. Hypercalcaemia due to metastatic parathyroid hormone-related peptide-secreting pancreatic neuroendocrine tumour is challenging to manage and requires a multimodality approach. Methods. We present a case of a woman undergoing liver transplantation for metastatic parathyroid hormone-related peptide-secreting pancreatic neuroendocrine tumour. Results. A young woman with a history of parathyroid ...
Mauz Paul-Stefan - - 2014
Recurrent respiratory papillomatosis (RRP) is a rare disease, which is characterised by the growth of papillomavirus-induced papillomas within the respiratory tract. Malignant transformation occurs in less than 1% of the cases. We report a case of human papillomavirus (HPV) type 11-associated juvenile-onset RRP (JORRP) initially diagnosed at the age of ...
Gilani S M - - 2014
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is an important modality for diagnosing solid and cystic pancreatic lesions. The objectives of this retrospective study are to review the cytologic criteria used to diagnose pancreatic solid pseudopapillary neoplasms (SPNs) and to evaluate the utility of EUS-FNA by correlating cytologic and histologic samples. ...
Limaiem F - - 2014
Pancreatic neuroendocrine tumours (pNET) are relatively uncommon, accounting for 1-2% of all pancreatic neoplasms. They are characterised by varying clinical presentation, tumour biology and prognosis. To provide an updated overview on clinicopathological features, treatment and outcome of pNET. In our retrospective study, we reviewed 9 cases of pNET that were ...
Laura Bongiovanni B Faculty of Veterinary Medicine, University of Teramo, Teramo, - - 2014
Asian palm civets (Paradoxurus hermaphroditus), or toddy cats, belong to the family Viverridae. Little is known about the pathology of these animals and few articles have been published, mainly concerning their important role as wild reservoir hosts for severe infectious diseases of domestic animals and human beings. A 4-year-old, female ...
van Bogaert Louis-Jacques LJ National Health Laboratory Service, Polokwane/Mangkweng Hospital Complex, and University of Limpopo, Polokwane, South - - 2014
The integration of high-risk (HR) human papillomavirus (HPV) in the cell genome is an essential step in the oncogenic pathway of lower ano-genital HPV-related squamous preinvasive and invasive lesions. The expression of HR-HPV surrogate biomarkers of HR-HPV integration by immunohistocytochemistry (IHC) serves as a diagnostic and/or a prognostic tool of ...
Mahawish Karim K Department of Elderly Care, Warrington Hospital, Warrington, - - 2014
We present the case of a 55-year-old Caucasian man presenting with polyarthritis, weight loss and multiple tender cutaneous nodules. Abnormal liver function tests prompted imaging of the liver which demonstrated liver metastases. Biopsy of the liver lesions confirmed the diagnosis of metastatic pancreatic neuroendocrine carcinoma.
Layfield Lester J LJ Address: Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, Missouri, - - 2014
The Papanicolaou Society of Cytopathology has developed a set of guidelines for pancreatobiliary cytology including indications for endoscopic ultrasound guided fine needle aspiration, terminology and nomenclature of pancreatobiliary disease, ancillary testing and post-biopsy management. All documents are based on the expertise of the authors, a review of the literature, discussion ...
Adler Douglas D Address: Division of Gastroenterology, Department of Internal Medicine at the University of Utah School of Medicine, Indianapolis, - - 2014
The Papanicolaou Society of Cytopathology has developed a set of guidelines for pancreaticobiliary cytology including indications for endoscopic ultrasound (EUS) and fine-needle aspiration (FNA) biopsy, techniques for EUS-FNA, terminology and nomenclature to be used for pancreaticobiliary disease, ancillary testing and postbiopsy management. All documents are based on expertise of the ...
Brugge William R WR Address: Department of Medicine, Gastroenterology Unit, Massachusetts General Hospital, Boston, MA, - - 2014
The Papanicolaou Society of Cytopathology has developed a set of guidelines for pancreatobiliary cytology, including indications for endoscopic ultrasound guided fine-needle aspiration biopsy, techniques of the endoscopic retrograde cholangiopancreatography, terminology and nomenclature of pancreatobiliary disease, ancillary testing, and postbiopsy management. All documents are based on the expertise of the authors, ...
Palmucci Stefano S Radiodiagnostic and Radiotherapy Unit, University Hospital "Policlinico-Vittorio Emanuele", Via Santa Sofia 78, 95123 Catania, - - 2014
Intraductal papillary mucinous neoplasms (IPMNs) represent a group of cystic pancreatic neoplasms with large range of clinical behaviours, ranging from low-grade dysplasia or borderline lesions to invasive carcinomas. They can be grouped into lesions originating from the main pancreatic duct, main duct IPMNs (MD-IPMNs), and lesions which arise from secondary ...
Kung Jonathan S JS Department of Medicine, Harbor UCLA Medical Center. Torrance, CA, USA. - - 2014
EUS with fine-needle aspiration and cyst fluid analysis is routinely used to evaluate pancreatic cysts; however, the clinical course of these lesions is often not well defined. Our study evaluated whether EUS imaging, cyst fluid CEA, and cytology combined with cyst fluid genetic analyses for allelic imbalance and genetic mutations ...
Abedi Seyed Hassan SH Shahid Beheshti University of Medical Sciences, Taleghani Hospital. Tehran, Iran. - - 2014
Primary pancreatic lymphoma (PPL) is rare but manageable malignant tumor of the pancreas which may be confused with pancreatic adenocarcinoma. We report a 38 year-old smoker man with IVDA and history of B (inactive carrier), C (Ia genotype) hepatitis and negative for HIV admitted to our hospital because of nausea, ...
Tewari Nilanjana N Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre National Institute of Health Research Biomedical Research Unit. Nottingham, UK. - - 2014
Pancreatic lymphoepithelial cysts are rare, benign cysts which can present diagnostic difficulties. Non-invasive imaging alone is unreliable in distinguishing between benign and malignant cysts. Endoscopic ultrasound (EUS) and fine needle aspiration (FNA) with analysis of cyst fluid is more reliable, but invasive. In addition, tumor markers such as carcinoembryonic antigen ...
Paramasivam Rajesh Kumar RK Department of Medicine, University Putra Malaysia. Seri Kembangan (Serdang), Selangor, Malaysia. - - 2014
There is scanty data on endoscopic palliative management of pancreatic cystic lesions that cause gastric outlet obstruction (GOO). This is the first case report that illustrates the use of a covered self-expandable metal stent (CSEMS) with an anti-migration system in the management of a symptomatic neoplastic cystic pancreatic lesion. A ...
Qin Shan-Yu SY Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, PR - - 2014
The diagnostic efficiency of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) cytology varies widely depending on the treatment method of the specimens. The present study aimed to evaluate the diagnostic efficacy of cell block (CB) immunohistochemistry, smear cytology (SC), and liquid-based cytology (LBC) in patients with pancreatic lesions without consulting an on-site ...
Gurram Krishna C KC http://orcid.org/0000-0002-0254-4648 Department of Gastroenterology, Allegheny General Hospital, Pittsburgh, Pennsylvania, - - 2014
Acute recurrent pancreatitis occurs rarely in individuals with pancreas divisum. A 39-year-old woman with no significant history presented with pancreatitis. CT scan and MRI suggested acute on chronic pancreatitis with calcifications and pancreatic divisum. An endoscopic ultrasound demonstrated complete pancreas divisum. A large calcification measuring 12 mm × 6 mm was seen ...
Monier Ahmed A Department of Radiology, Hamad Medical Corporation, Hamad General Hospital, Doha, - - 2014
Heterotopic pancreas is a rare developmental anomaly defined as pancreatic tissue found on ectopic sites without contiguity with the main pancreas. An isolated heterotopic pancreas as a cause of bowel intussusception is extremely rare. A case of 47-year old male with multiple episodes of melena, constipation and abdominal pain for ...
Larsen Anne K AK Department of Plastic Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark; and Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev, - - 2013
Malignant melanomas rarely develop isolated pancreatic metastases. We describe a unique patient who is still alive 22 years following an isolated pancreatic melanoma metastasis, and we review the sparse literature in the field.
Ramanathan Subramaniyan S Department of Radiology, The Ottawa Hospital, University of Ottawa, Ottawa, ON - - 2014
Pancreatic involvement in acute lymphoblastic leukemia (ALL) is uncommon more so in adults. It can present as obstructive jaundice, pancreatitis or can be asymptomatic. We report here the clinical and imaging features in a 28 years old man with B cell ALL with simultaneous involvement of pancreas and bilateral kidneys. Computed ...
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