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Oduyebo Ibironke I Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, USA, - - 2014
Choledochal cysts (CC) are a cystic dilation of the intra- or extrahepatic biliary tree. They are rare, and are associated with a risk of malignant transformation. Due to the close proximity to the pancreas, Type II CC, in which a diverticular outpouching is connected to the extrahepatic bile duct via ...
Crosara Stefano S Stefano Crosara, Mirko D'Onofrio, Riccardo De Robertis, Emanuele Demozzi, Stefano Canestrini, Giulia Zamboni, Roberto Pozzi Mucelli, Department of Radiology, University Hospital GB Rossi, University of Verona, 37134 Verona, - - 2014
Autoimmune pancreatitis (AIP) is characterized by obstructive jaundice, a dramatic clinical response to steroids and pathologically by a lymphoplasmacytic infiltrate, with or without a pancreatic mass. Type 1 AIP is the pancreatic manifestation of an IgG4-related systemic disease and is characterized by elevated IgG4 serum levels, infiltration of IgG4-positive plasma ...
Tone Kiyoshi K Department of Pathology, Hirosaki University Hospital, Hirosaki, Aomori, - - 2014
Intraoperative diagnosis of resection margins in the biliary tract and pancreas tumors is important in deciding extent of resection; however, diagnosis based solely on frozen sections is sometimes difficult. Therefore, we investigated the usefulness of intraoperative cytology (IC) combined with frozen section (FS) histology. We present the results with a ...
Cappelli Carla C Diagnostic and Interventional Radiology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy, - - 2014
Preoperative suspicion of malignancy in pancreatic neuroendocrine tumours (pNETs) is mostly based on tumour size. We retrospectively reviewed the contrast enhancement pattern (CEP) of a series of pNETs on multiphasic multidetector computed tomography (MDCT), to identify further imaging features predictive of lesion aggressiveness. Sixty pNETs, diagnosed in 52 patients, were ...
Ardelean Melania M Department of Gastroenterology and Hepatology,"Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania. - - 2014
The AIM of this study was to summarize the spectrum of pancreatic pathology assessed by contrast enhanced ultrasound (CEUS) in a single Gastroenterology Center and to emphasize its accuracy in assessing two of the most important pancreatic lesions: solid tumors and necrotic lesions in acute pancreatitis. Our retrospective study included ...
Matsubayashi Hiroyuki H Hiroyuki Matsubayashi, Naomi Kakushima, Kohei Takizawa, Masaki Tanaka, Kenichiro Imai, Kinichi Hotta, Hiroyuki Ono, Division of Endoscopy, Shizuoka Cancer Center, Shizuoka 411-8777, - - 2014
Autoimmune pancreatitis (AIP) is a distinct form of chronic pancreatitis that is increasingly being reported. The presentation and clinical image findings of AIP sometimes resemble those of several pancreatic malignancies, but the therapeutic strategy differs appreciably. Therefore, accurate diagnosis is necessary for cases of AIP. To date, AIP is classified ...
Filip Rafał R Rafał Filip, Department of Clinical Endoscopy, Institute of Rural Health, 20-090 Lublin, - - 2014
The heterotopic pancreas, which is usually described as an untypical presence of pancreatic tissue without any anatomic or vascular continuity with the pancreas, is relatively rare. Clinical manifestations may include bleeding, inflammation, pain and obstruction; however, in most cases it remains silent and is diagnosed during autopsy. Here, we report ...
Bergeron Joseph P JP Department of Pathology, Medical University of South Carolina, Charleston, South - - 2014
Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has emerged as the diagnostic modality of choice for mass lesions in the pancreas. The objective of the current study was to determine the accuracy and pitfalls of EUS-FNA in the diagnosis of pancreatic lesions in cases that involved follow-up surgical resection. Cases of EUS-FNA ...
Lobetti Remo R Bryanston Veterinary Hospital, Bryanston, South Africa - - 2014
A 9-year-old castrated domestic shorthair cat was presented with a 6 week history of progressive non-pruritic alopecia, polyphagia and weight loss. A diagnosis of lymphocytic mural folliculitis was made and the cat was treated with a combination of prednisolone and ciclosporin; this produced an improvement in the alopecia but no ...
Franchello Alessandro A Department of Surgery, Molinette Hospital, Turin, Italy. Electronic address: - - 2014
Autoimmune pancreatitis (AIP) is a rare pancreatic disorder among chronic pancreatitis that can mimick pancreatic cancer (PC). Patients with type 1 AIP usually present obstructive jaundice associated with high level of IgG4 in serum and a pancreatic mass at radiological imaging; these disorders may be associated with other organs lesions ...
Oh Hyoung-Chul HC Division of Gastroenterology, Chung-Ang University College of Medicine, Seoul, - - 2014
Pancreatic cystic lesions are being diagnosed with increasing frequency owing to the widespread use of cross-sectional imaging. Although most pancreatic cysts are detected incidentally, they represent a wide spectrum of histopathology, and neoplastic cysts appear to be more prevalent than previously estimated. Some histologic types have malignant potential. Considering the ...
Crain Sarah K SK Tufts University Cummings School of Veterinary Medicine, North Grafton, MA, USA - - 2014
The safety of fine-needle aspiration (FNA) of the feline pancreas has not been reported. The incidence of complications following ultrasound-guided pancreatic FNA in 73 cats (pancreatic aspirate [PA] cats) with clinical and ultrasonographic evidence of pancreatic disease was compared with complications in two groups of matched control cats also diagnosed ...
Do Richard K G RK 1 Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY - - 2014
OBJECTIVE. The purpose of this retrospective study was to measure interobserver agreement in the assessment of malignant imaging features of intraductal papillary mucinous neoplasms (IPMNs) on MDCT. MATERIALS AND METHODS. Pancreatic protocol CT studies were reviewed for 84 patients with resected IPMNs. Maximal diameter of the dominant cyst, presence of ...
Yano Masaaki M Department of Gastroenterology, Public Central Hospital of Matto - - 2014
A 29-year-old man with ulcerative colitis presented to the hospital complaining of persistent back pain. Pancreatic enzymes and tumor markers were elevated; imaging showed diffuse narrowing of the main pancreatic duct associated with diffuse pancreatic enlargement. We therefore performed an endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) biopsy of the pancreas ...
Caraiani C C Department of Radiology and Computed Tomography, "Octavian Fodor" Institute of Gastroenterology and Hepatology, Cluj-Napoca, - - 2014
Hemosuccus pancreaticus is defined as upper gastrointestinal hemorrhage from the ampulla of Vater via the pancreatic duct. It is a rare disease, with non-specific presentation, challenging to diagnose and difficult to treat, with high mortality rates in untreated patients with massive bleeding. Given the intermittent nature of the bleeding, delays ...
Vinayek Rakesh R 1 Digestive Endoscopy Unit, Catholic University, Rome, Italy ; 2 Division of Gastroenterology, Sinai Hospital, Baltimore, USA ; 3 Division of Digestive and Liver Disease, University La Sapienza, Rome, - - 2014
Pancreatic neuroendocrine neoplasms (p-NENs) are rare and characterized by an indolent course, with a much better prognosis than non-neuroendocrine tumors of the pancreas. In the non-functional class of p-NENS, surgery remains the only curative treatment for early localized disease, but there are few therapeutic options for advanced disease. The prognosis ...
Akbulut Sami S Sami Akbulut, Ridvan Yavuz, Firat Demircan, Department of Surgery, Diyarbakir Education and Research Hospital, Diyarbakir 21400, - - 2014
To overview the literature on pancreatic hydatid cyst (PHC) disease, a disease frequently misdiagnosed during preoperative radiologic investigation. PubMed, Medline, Google Scholar, and Google databases were searched to identify articles related to PHC using the following keywords: hydatid cyst, hydatid disease, unusual location of hydatid cyst, hydatid cyst and pancreas, ...
Krishna Somashekar G SG Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Medical Center, Columbus, Ohio, - - 2014
Pancreatic ductal adenocarcinoma (PDAC), pancreatic neuroendocrine tumors (pNET), and metastatic lesions (pMET) are the most common neoplastic solid pancreatic lesions (SPLs). Early diagnosis enables prompt treatment. To identify factors differentiating PDAC from non-PDAC lesions and assess the accuracy of EUS-guided FNA. Retrospective tertiary center. Consecutive patients referred for EUS evaluation ...
Al-Jiffry Bilal O - - 2014
Microcystic adenoma or serous cystadenoma (SCA) is an uncommon tumor type, accounting for only 1-2% of pancreatic exocrine neoplasms. Usually unifocal, SCAs present as single, large, well-demarcated, multiloculated, cystic tumors, 1-25 cm in size. A 73-year-old man initially presented with epigastric abdominal pain and was diagnosed with SCA involving the ...
Napoléon Bertrand B Department of Gastroenterology, Hôpital privé Jean Mermoz, Générale de Santé, Lyon, - - 2014
Background and study aims: The differential diagnosis of solitary pancreatic cystic lesions is frequently difficult. Needle-based confocal laser endomicroscopy (nCLE) performed during endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a new technology enabling real-time imaging of the internal structure of such cysts. The aim of this pilot study was to identify ...
Unal Betül B Akdeniz University, Antalya, Turkey - - 2014
Here, we present the case of a 31-year-old woman patient who underwent distal pancreatectomy with the history of gastric bypass surgery for obesity. The final histopathological diagnosis of the lesion was nesidioblastosis. Nesidioblastosis is the most common cause of organic persistent hyperinsulinemic hypoglycemia in newborns; however, it is rare in ...
Al-Haddad Mohammad A MA Department of Medicine, Indiana University, Indianapolis, Indiana, - - 2014
Background and study aims: Current diagnostic testing is inadequate to determine the malignant potential of pancreatic cysts, resulting in overcautious patient management. Integrated molecular pathology (IMP) testing combines molecular analysis with first-line test results (cytology, imaging, and fluid chemistry) to assess the malignant potential of pancreatic cysts. This multicenter study ...
Johnson Adam A Department of Microbiology, Immunology and Pathology, Vanderbilt University Medical Center, Nashville, TN, - - 2014
Recently, we described a series of pancreatic neuroendocrine tumours (PanNETs) featuring prominent stromal fibrosis, which we called sclerosing PanNETs. The aim of this study was to examine the pathological, immunophenotypic and clinical differences between sclerosing and non-sclerosing PanNETs. One hundred and six PanNETs were identified, of which 15 (14%) were ...
Fabbri Carlo C Unit of Gastroenterology and Digestive Endoscopy, AUSL Bologna Bellaria-Maggiore Hospital, Via Altura, 40139, Bologna, Italy, - - 2014
Early detection of small pancreatic cancer is important because expected survival is markedly better for tumors ≤2 cm. A new endoscopic ultrasound-(EUS) guided biopsy needle with side fenestration has been recently developed to enable fine-needle biopsy (FNB) under EUS guidance. The aim of this study was to evaluate the outcome of ...
Ashkar M M Department of Medicine, St. Elizabeth's Medical Center, Brighton, MA - - - 2014
Since its introduction, Endoscopic Ultrasonography (EUS) has been increasingly gaining more attention for diagnosing various gastrointestinal conditions. We aim to systematically review the literature and highlight the benefit of using EUS in different pancreatic diseases by primarily reviewing its importance in diagnosing, treating pancreatic pathologies, comparing its accuracy to other ...
Wang Jin J Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, - - 2014
Intraductal papillary mucinous neoplasm (IPMN) is a precursor cystic lesion to pancreatic cancer. With the goal of classifying IPMN cases by risk of progression to pancreatic cancer, we undertook an exploratory Next Generation Sequencing (NGS) based profiling study of miRNAs (miRNome) in the cyst fluids from low grade- benign and ...
Affirul C A CA Medical Faculty, Universiti Sains Islam Malaysia, 55100 Kuala Lumpur, Malaysia. Electronic address: - - 2014
Solid pseudo papillary pancreatic tumour is a rare entity. The atypical presentation causes a delayed or misdiagnosis of these pathology. It commonly affects the female population in the 2nd and 3rd decade of life. The presentation varies from non-specific abdominal pain to incidental findings in asymptomatic patients. It is a ...
Nakanuma Yasuni Y Department of Pathology, Shizuoka Cancer Center, Shizuoka, - - 2014
The biliary tract and pancreas develop from the foregut at almost same time, and the morphology of the biliary tract and pancreatic ducts share several features. In addition, there are peribiliary glands around the biliary tract, which occasionally contain pancreatic acini and enzymes. Some pancreatic and biliary tract diseases share ...
Jang Kee-Taek KT Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, - - 2014
The pathologic description for neoplastic polyps of the gallbladder (GB) was controversial. Although current WHO suggest adenoma and papillary neoplasm for precursor lesions, the distinction is not clear. In recent study for 123 GB cases, we found tumoral preinvasive neoplasms (≥1 cm) were analogous to their pancreatic and biliary counterparts. They ...
Yau Wilson W Department of Pathology, College of Veterinary Medicine, The University of Georgia, Athens, - - 2014
A 13-year-old female Boer goat with a history of chronic arthritis and recurrent episodes of recumbency, increased serum gamma-glutamyl transferase, and complete inability to stand was submitted for necropsy. Gross changes included the presence of a white, firm, smooth, 6 cm × 4 cm × 3 cm mass that diffusely ...
Marinos Emmanuel E The University of Sydney, Sydney, - - 2014
Endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) is a technique frequently used to diagnose solid and cystic lesions of the pancreas. Antibiotic prophylaxis has been recommended for EUS-FNA of pancreatic cystic lesions but is not universally observed. The most effective antibiotic and the most efficacious route and regimen of administration are ...
Johnson Eric A EA Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, - - 2014
Primary pancreatic lymphoma (PPL) is a rare pancreatic neoplasm that is difficult to diagnose. PPL has a vastly different prognosis and treatment regimen than other pancreatic tumors; therefore, accurate diagnosis is vital. In this article, we describe the characteristic presentation, endoscopic ultrasound (EUS) features, and the role of fine-needle aspiration ...
Jung Hae Il HI Hae Il Jung, Taesung Ahn, Myoung Won Son, Sang Ho Bae, Moon Soo Lee, Chang Ho Kim, Department of Surgery, Soonchunhyang University Cheonan Hospital, Cheonan 330-721, South - - 2014
Cystic lymphangiomas of the adrenal gland are rare. A 79-year-old female presented in the emergency room with epigastric discomfort, and an immovable mass was palpated in her abdomen upon physical examination. Imaging studies revealed a large cystic lesion in the pancreatic tail. The radiologic impression ruled out the possibility of ...
Kim John J JJ Division of Gastroenterology, Loma Linda University Medical Center, 11234 Anderson Street, Room 1556, Loma Linda, CA, 92354, USA, - - 2014
In jaundiced patients with suspected pancreatic cancer, endoscopic retrograde cholangiopancreatography (ERCP) with biliary stent is frequently performed prior to histologic diagnosis by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). To compare the accuracy of jaundiced patients undergoing EUS-FNA for a pancreatic mass with or without a biliary stent. Consecutive patients with a ...
Chang Xiaoyan - - 2014
BackgroundIntraductal tubular adenoma of the pancreas, pyloric gland type (ITA), is an infrequent intraductal benign lesion located in the main duct and large branch duct of the pancreas. The purpose of this report is to introduce seven new cases and to compare their clinicopathologic features and KRAS mutations to gastric-type ...
Ramesh Jayapal J From the *Division of Gastroenterology and Hepatology and †Department of Pathology, University of Alabama at Birmingham, Birmingham, AL; and ‡Center for Interventional Endoscopy, Florida Hospital, Orlando, - - 2014
Although a large gauge needle can procure more tissue at endoscopic ultrasound-guided fine needle aspiration (EUS-FNA), its advantage over smaller needles is unclear. This study compared flexible 19G and 25G needles for EUS-FNA of solid pancreatic masses. This was a randomized trial of patients undergoing EUS-FNA of pancreatic masses using ...
D'Onofrio M - - 2014
Purpose: To evaluate CEUS for the diagnosis of pancreatic diseases and its application in the clinical routine with a focus on the value of CEUS in ductal pancreatic carcinoma and its use for the differentiation of neoplastic and non-neoplastic lesions. Materials and Methods: All prospective and retrospective studies published in ...
Castellano-Megías Víctor M VM Víctor M Castellano-Megías, Department of Pathology, Hospital Universitario de Fuenlabrada, 28942 Fuenlabrada, Madrid, - - 2014
Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a noninvasive epithelial neoplasm of mucin-producing cells arising in the main duct (MD) and/or branch ducts (BD) of the pancreas. Involved ducts are dilated and filled with neoplastic papillae and mucus in variable intensity. IPMN lacks ovarian-type stroma, unlike mucinous cystic ...
Antonini Filippo F Department of Gastroenterology, A.Murri Hospital, Polytechnic University of Marche, Fermo, Italy. Electronic address: - - 2014
An asymptomatic 55-year-old woman with no significant past medical history was referred for a incidental detection of a small pancreatic mass. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of the pancreatic lesion was performed with a 25-gauge ProCore needle (Cook Endoscopy, Winston Salem, NC) to obtain a tissue diagnosis. Histology of the ...
Unno Jun J Division of Gastroenterology, Tohoku University Graduate School of Medicine , Sendai , - - 2014
Abstract Background. We assessed the controversial topic of using 22-gauge needles in endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis and evaluation of Ki67 labeling indices (Ki67LI) of pancreatic neuroendocrine tumors (pNET). Methods. Thirty-eight patients with pNET who underwent EUS-FNA between January 1, 2008 and December 31, 2012 were ...
Fukushima Noriyoshi N Department of Pathology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan. Electronic address: - - 2014
Mucinous cystic neoplasms (MCNs) of the pancreas are primary pancreatic cyst-forming neoplasms that can be a precursor to invasive adenocarcinoma of the pancreas. MCNs occur almost exclusively in the distal pancreas of middle-aged women. MCNs typically show a "cyst-in-cyst" pattern of growth and are well encapsulated by a thick fibrous ...
Bang Ji Young JY Center for Interventional Endoscopy, Florida Hospital, Orlando, FL, - - 2014
When performing endoscopic ultrasound-guided fine needle aspiration (EUS-FNA), identifying neoplasia in the setting of chronic pancreatitis can be technically challenging. The morphology of an ill-defined mass on sonography, presence of calcifications or intervening collaterals, reverberation from a biliary stent, low yield of tissue procurement, and interpretative errors in cytopathology can ...
Lee Seong Jun SJ Department of Internal Medicine, Pusan National University School of Medicine, Busan, - - 2014
Ectopic pancreas is a congenital anomaly and the most common type of ectopic tissue in the gastrointestinal tract. Most patients with an ectopic pancreas are asymptomatic and rarely have complications. Ectopic pancreatitis after an endoscopic biopsy has not been reported. We report a patient who developed acute ectopic pancreatitis in ...
Sharma Pankaj P Professor, Department of Radiodiagnosis, Army Hospital (Research & Referral) , Delhi Cantt, India - - 2014
Pancreatic endocrine tumours are rare in occurrence. They may present with a baffling range of symptoms which pose a diagnostic dilemma. Two cases of pancreatic insulinoma are presented herewith. Both presented with neuro-psychiatric complaints and were treated symptomatically for depression, anxiety, seizures etc. The diagnosis in these patients was missed ...
Virgilio Edoardo E Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology "Sapienza", St. Andrea Hospital, via di Grottarossa 1035-39, Rome 00189, Italy. Electronic address: - - 2014
Solid-pseudopapillary neoplasms (SPNs) of the pancreas are infrequent tumors since, as of 2014, only 2744 patients have been described. Its rarity, unclear histogenesis, pleomorphic aspect on radiology (cystic, solid or mixed) and unpredictable biological behavior with an insidious high-grade malignant potential make SPN difficult to recognize preoperatively even in its ...
Kitchens William H WH Department of Surgery, Massachusetts General Hospital, ACC 366 15 Parkman St., Boston, MA, 02114, - - 2014
A case of pancreatitis secondary to a hepatic hydatid cyst is illustrated together with its preoperative imaging and intraoperative appearance. Cystobiliary communication is a common complication of large hydatid cysts, and episodes of recurrent pancreatitis resulting from passage of cyst contents down the biliary tract are rarely described. The clinical ...
Bournet Barbara B Barbara Bournet, Louis Buscail, Department of Gastroenterology, CHU Toulouse Rangueil, University of Toulouse, 31059 Toulouse, - - 2014
Pancreatic ductal adenocarcinoma remains one of the most deadly types of tumor. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a safe, cost-effective, and accurate technique for evaluating and staging pancreatic tumors. However, EUS-FNA may be inconclusive or doubtful in up to 20% of cases. This review underlines the clinical interest of ...
Iacono Calogero C Department of Surgery, Division of General Surgery A, Unit of Hepato-Pancreatico-Biliary-Surgery, University of Verona Medical School, Verona, Italy. Electronic address: - - 2014
Head dorsal pancreatectomy (HDP) is a segmental pancreatic resection, conservative variant of total dorsal pancreatectomy, applied to preserve the functional pancreatic parenchyma as an alternative to pancreaticoduodenectomy in not enucleable benign or low-grade malignant lesions. The absences of biliary and gastrointestinal resection/reconstruction are the other advantages of the technique. We ...
Ali Sadaf S Department of Surgical GE, SKIMS, Soura, Srinagar, Jammu and Kashmir, - - 2014
Cystic tumors of the pancreas are rare and can be confused with hydatid cyst especially in endemic areas like ours. We present a 30-year-old woman with a huge mucinous cystadenoma of the pancreas initially diagnosed and prepared on table as hydatid cyst. After incising the cyst the diagnosis of cystic ...
Limaiem Faten F Department of Pathology, Mongi Slim Hospital, Université de Tunis El Manar, Faculté de Médecine de Tunis, La Marsa, - - 2014
Cystic neoplasms of the pancreas are rare and constitute approximately 0.5% of all pancreatic neoplasms. The study was to describe clinicopathological features of pancreatic cystic tumors. In our retrospective study, we reviewed 10 cases of pancreatic cystic neoplasms that were diagnosed at the pathology department of Mongi Slim hospital over ...
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