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Lally Lindsay L Division of Rheumatology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA. Electronic address: - - 2015
This article provides an update on the diagnosis and management of the antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides, granulomatosis with polyangiitis (formerly Wegener), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss). Focus is on new schemes of classification and the importance of ANCAs in the diagnosis and prognosis of these ...
Bomback Andrew S AS Department of Medicine, Division of Nephrology, Columbia University Medical Center, New York, N.Y., - - 2014
A major shift in our understanding of the membranoproliferative glomerulonephritis (MPGN) lesion is the focus on which components of the complement pathway are involved in mediating renal injury. Hence, MPGN is no longer classified solely by ultrastructural findings on biopsy but instead divided into immune complex-mediated lesions versus complement-mediated lesions. ...
Bosseila Manal M Dermatology Dept, Cairo University, Cairo Egypt. Electronic address: - - 2014
Monitoring of tumour burden during mycosis fungoides (MF) treatment, is crucial to adjust therapy accordingly. This is usually achieved through combined by clinical assessment with histopathological and immunohistochemical evaluation. To assess the validity of fluorescence diagnosis (FD) in the measurement of response to therapy in early MF, using in comparison ...
Goyal Nilesh N NN Juvenis Clinic, Santacruz West, Mumbai, India, and Bombay Hospital & Lilavati Hospital, Mumbai, - - 2014
Keloids and hypertrophic scars remain one of the more difficult treatment concerns for clinicians. A variety of therapies have been used in the past with moderate success. On occasion, combination therapy has been used to treat these lesion, in an attempt to lessen the symptoms of pain and pruritus that ...
Kearney Mary-Carmel MC School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, - - 2014
Photodynamic therapy can be used in the treatment of pre-malignant and malignant diseases. It offers advantages over other therapies currently used in the treatment of skin lesions including avoidance of damage to surrounding tissue and minimal or no scarring. Unfortunately, systemic delivery of photosensitising agents can result in adverse effects, ...
Khan Tanya T TT *Department of Ophthalmology, Louisiana State University Health Sciences Center; †Department of Ophthalmology, Ochsner Clinic Foundation, New Orleans, Louisiana, U.S.A.; and ‡Charlotte Eye Ear Nose & Throat Associates, Charlotte, North Carolina, - - 2014
Minocycline is a tetracycline antibiotic commonly used to treat acne and rosacea. Although pigmentation of the skin, nails, teeth, oral mucosa, and sclera is a well-recognized adverse outcome associated with minocycline, ocular pigmentation may be missed on routine examination. The authors present a case of a 43-year-old Caucasian woman who ...
Giard Marie-Claude MC Rheumatology Department, Verdun Hospital, 4000, Boulevard La Salle, Montreal, QC, H4G 2A3, Canada, - - 2014
Ultrasonographic characteristics of two common musculoskeletal lesions, ganglion cysts (GCs) and synovial cysts (SCs) are presented through a review of the literature. Although similar in many ways, these two lesions display different morphostructural characteristics justifying, in our view, their descriptions as separate entities. Mainly different from an anatomopathologic point of ...
Dohi Tomotaka T Columbia University Medical Center, New York, NY, USA Cardiovascular Research Foundation, 111 East 59th Street, 12th Floor, New York, NY 10022, - - 2014
To evaluate the relationship between lipid content and plaque morphometry as well as the process of lesion progression and regression in patients with significant coronary artery disease. The present study, using data from the YELLOW trial, was conducted in patients having significant coronary lesions (fractional flow reserve <0.8) who underwent ...
John Seby S Cerebrovascular Center, Cleveland Clinic, Cleveland, - - 2014
Central nervous system vasculitis (CNSV) is a complex disease that poses considerable diagnostic and therapeutic challenges. It is divided into primary angiitis of the CNS (PACNS), or secondary angiitis of the CNS when associated with systemic conditions. Clinical presentation can be extremely variable and there is no classic presentation. In ...
Wu Hsin-Chieh HC 1] Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan [2] Institute of Biological Chemistry, Academia Sinica, Taipei 115, - - 2014
The promyelocytic leukaemia (PML) protein controls multiple tumour suppressive functions and is downregulated in diverse types of human cancers through incompletely characterized post-translational mechanisms. Here we identify USP11 as a PML regulator by RNAi screening. USP11 deubiquitinates and stabilizes PML, thereby counteracting the functions of PML ubiquitin ligases RNF4 and ...
Tsuchiya Atsushi A Department of Neurology, St. Marianna University School of Medicine Yokohama City Seibu Hospital, - - 2014
A spinal cord lesion is a rare manifestation of neurosarcoidosis. We herein report a case with dysuria and gradually worsening numbness in both lower extremities. Thoracic magnetic resonance imaging (MRI) revealed a long spinal cord lesion with gadolinium enhancement in the lower part of the lesion. Chest computed tomography demonstrated ...
Niño Carlos A - - 2013
Ubiquitination is a highly dynamic and versatile posttranslational modification that regulates protein function, stability, and interactions. To investigate the roles of ubiquitination in a primitive eukaryotic lineage, we utilized the early-branching eukaryote Giardia intestinalis. Using a combination of biochemical, immunofluorescence-based, and proteomics approaches, we assessed the ubiquitination status during the ...
Yamada Tsutomu - - 2013
The histologic characteristics of air space enlargement with fibrosis (AEF) are compared with usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP) and centrilobular emphysema (CLE) to determine similarities and differences. Lung specimens from 39 patients were studied; 9 with AEF, 13 with UIP and 5 with CLE identified in lobectomy ...
Faoro Valentina - - 2012
The availability of a new E7 mAb-based immunohistochemistry (IHC) detection assay, Cervimax, allowed for the first time reliable testing of the E7 protein marker in formalin-fixed and paraffin-embedded tissues from cervical lesions. E7-specific IHC staining patterns were compared with those patterns of cervical cancer biomarkers, including the viral capsid protein ...
Mizukoshi Waka - - 2013
To compare the diagnostic capability of proton ((1)H) magnetic resonance spectroscopy (MRS) in differentiating benign from malignant breast lesions on the basis of qualitative and quantitative approaches. We performed single-voxel (1)H MRS for 208 breast lesions, identified a clear total composite choline compounds (tCho) peak of signal-to-noise of ≥2 to ...
Monrad-Hansen Peter Wiel - - 2012
Endometrial cyst of the pancreas was first described in 1984. The condition is extremely rare, and only a few case reports have been described. Herein we present a case report of a peripancreatic endometriosis cyst in a perimenopausal woman. Computed tomography, magnetic resonance imaging, and regression of the cyst during ...
Deshpande Aparna - - 2012
Hepatoduodenal ligament cysts are rare. These may be confused with hepatic cysts even on advanced investigative modalities like Computerized tomography scanning or Magnetic Resonance Imaging. Diagnosis is often an intraoperative surprise. Laparoscopic treatment of such hepatoduodenal cysts is not described in available medical literature. We report one such case treated ...
Hembree Walter C WC Union Memorial Hospital, Orthopaedic Surgery, Baltimore, MD, USA. - - 2012
Osteochondral lesions of the talus (OLT) traditionally have been thought to occur anterolaterally or posteromedially. Recent studies utilizing magnetic resonance imaging (MRI) have questioned this teaching. The purpose of this study was to use MRI to describe the location, frequency, and morphology of OLT and determine if any correlations exist ...
Weiss W - - 2012
Purpose: To extend CADx techniques for High Spectral and Spatial Resolution (HiSS) breast MRI, and to assess the ability of the Lorentzian-fit- subtraction residual maxima of the water resonance spectra to distinguish between benign and malignant breast lesions on a voxel-by-voxel basis. Methods: HiSS high resolution spectroscopic MR images were ...
Kuiper Teaco - - 2012
BACKGROUND & AIMS:: When small colorectal lesions are accurately characterized, adenomas can be removed and discarded without formal histopathology analysis. Previous studies in an academic setting showed that many lesions can be managed accurately based on their endoscopic image (optical diagnosis). We performed a prospective study to assess the accuracy ...
Grantham Jared J - - 2012
In autosomal dominant polycystic kidney disease, progressive renal enlargement secondary to expanding cysts is a hallmark. The total cyst load and range of cyst diameters are unknown. The purpose of this study was to quantify the total number and range of diameters of individual cysts in adults with preserved GFR. ...
Tannaphai Penampai - - 2012
This study aimed to estimate the frequency and timing of washout in a series of pathologically proven benign mass-like breast lesions at dynamic magnetic resonance imaging. Institutional review board approval was obtained for this retrospective study. We evaluated enhancement kinetics of 33 pathologically confirmed benign breast lesions: fibroadenomas (n = ...
Torregrossa Liborio - - 2012
Cytological analysis of thyroid nodules detected using ultrasound guided fine-needle aspiration technique is an efficient method for the diagnosis of well-differenciated tumors such as papillary thyroid carcinoma. However, for between 10 to 30% of all the nodules, the cytological analysis based on fine-needle aspiration biopsies leads to an "indeterminated" identification. ...
Patankar A P - - 2012
Intramedullary dermoid cysts are rare tumors, especially those not associated with spinal dysraphism. Only six cases have been reported in the literature. Of these, only two cases have had magnetic resonance imaging studies. We report a case of an 18-year-old female patient, who presented with progressive weakness of both the ...
Wong Alan - - 2012
HR-MAS 1H NMR spectroscopy of tissue biopsies combined with chemometric techniques has emerged as a valuable methodology for disease diagnosis and environmental assessments. However the tissue mass required for such experiments is of the order of 10 mg and this can compromise the metabolic evaluation because of tissue heterogeneity. Tissue ...
Montaruli Ernesto - - 2012
A case of prenatal diagnosis of congenital mesoblastic nephroma by magnetic resonance is described.
Rolfe Heidi M - - 2012
Background/Objectives:  Accurate identification of skin lesions is vital in ensuring malignancies are not missed and that they are treated early to avoid mortality. It is also important that appropriate lesions are submitted for biopsy to decrease the costs and morbidity associated with the unnecessary removal of benign lesions. This study ...
Miscusi Massimo - - 2012
We report the case of a 72-year-old man who underwent surgery for a mobile spondylolisthesis L4-L5. Six months later, magnetic resonance imaging revealed an extradural cyst of the ligamentum flavum at L5-S1, which was then removed. Histological examination revealed a ganglion cyst of the ligamentum flavum. Cyst formation could be ...
Kousi E - - 2012
To determine whether in vivo proton magnetic resonance spectroscopy at 3T can provide accurate breast lesion characterization, and to determine the effect of gadolinium on the resonance of tCho. Twenty-four positive-mammogram patients were examined on a 3T MR scanner. 1H-MRS was performed before and after gadolinium administration. tCho peak was ...
Kim Won I - - 2011
To report a patient who developed open-angle glaucoma, secondary to bilateral perilimbal conjunctival lymphoid infiltrates without intraocular involvement that resolved after treatment with systemic rituximab. Observational case report. Review of historic, clinical, and photographic data of a 67-year-old woman with non-Hodgkin lymphoma of the axillary and cervical lymph nodes and ...
Hjelkrem M - - 2011
Background  The non-alcoholic fatty liver disease (NAFLD) activity score (NAS) is a scoring system designed by the Nonalcoholic Steatohepatitis (NASH) Clinical Research Network (CRN) to encompass the spectrum of NAFLD and evaluate histological changes. However, the NAS and the correlation between the NAS and a diagnosis of NASH have not ...
Kundu Reetu - - 2011
Body cavity fluid examination sometimes presents a diagnostic challenge in cytology practice. This study was undertaken to evaluate efficacy of cytomorphology, epithelial membrane antigen immunocytochemistry (EMA-ICC) and DNA flow cytometry (FCM) in detection of malignant cells in effusions. One hundred effusions (55 pleural, 44 ascitic, and 1 pericardial fluid) were ...
Minot Douglas M - - 2011
To examine the performance of our large pulmonary transthoracic fine needle aspiration/core biopsy (FNA/CB) practice over time, we performed a retrospective analysis of data from 333 consecutive procedures performed in 1996-1998 and 568 consecutive procedures performed in 2003-2005. Fluoroscopic guidance was performed more frequently in the earlier cohort, while a ...
Ludwin Artur - - 2011
To evaluate the diagnostic accuracy of sonohysterography (SHG), hysterosalpingography (HSG) and diagnostic hysteroscopy (DH) in uterine anomaly detection and to assess the role of these various modalities in the differential diagnosis of arcuate, septate and bicornuate uteri. Eighty-three women, with a history of recurrent spontaneous abortions or infertility and initial ...
Bittinger Sophie E - - 2011
To describe the detection of Hodgkin lymphoma within ovarian tissue taken at the time of harvest for cryopreservation. Case report. University-affiliated women's hospital. A 19-year-old woman diagnosed with Hodgkin lymphoma. Laparoscopic removal of ovarian tissue for cryopreservation. Histologic and immunohistochemical evaluation of ovarian tissue harvested for fertility preservation. Histologic and ...
Vasiliu Viorel - - 2010
Anorectal Hodgkin lymphoma (HL) is rare, mainly described in human immunodeficiency virus (HIV) patients with exceptional cases reported in immunocompetents. We report the case of a middle age HIV male, presenting with intestinal occlusion. Rectosigmoidoscopy showed multiple anorectal nodular and ulceronecrotic masses. The biopsy specimens revealed a diffuse polymorphous inflammatory ...
Huda S - - 2010
A 74-year-old lady presented to a district hospital with ataxia, a left sixth nerve palsy, and a sensorimotor neuropathy over a several month period. Baseline blood tests revealed a macrocytic anaemia, but were otherwise unremarkable. Tumour markers, autoimmune and initial screening of causes of macrocytosis were negative. In particular onconeuronal ...
Cheuk Wah - - 2010
Idiopathic cervical fibrosis is a rare tumefactive inflammatory-sclerosing lesion involving the soft tissues of the head and neck, and a proportion of patients also have synchronous or metachronous inflammatory fibrosclerosing lesions in other anatomic sites. The latter finding suggests that this entity may represent a member of IgG4-related sclerosing diseases. ...
Mozaheb Z - - 2011
Global variations in the frequency of the major sub-types of lymphoma have been reported. However, studies on different sub-types of adult malignant lymphoma had never been conducted in Mashhad, Iran. In this paper, we aimed to identify the major sub-types of malignant lymphoma in our area and compare the distribution ...
Eun Bahn Young - - 2010
A 71-year-old man presented with mucosa-associated lymphoid tissue (MALT) lymphoma of the submandibular gland 52 months after initial diagnosis of MALT lymphoma of the lung. Ultrasonography showed a well-demarcated, markedly hypoechoic, heterogeneous solid mass with linear echogenic strands and hypervascularity. Ultrasound-guided core-needle biopsy demonstrated histological findings of MALT lymphoma. Sonographic ...
Montes-Moreno S - - 2011
Thomas Hodgkin's and Samuel Wilks first recognized Hodgkin disease in the first half of the 19th century. Initially described as lymphogranulomatosis, it was later recognized to be a lymphoid neoplasm derived from B cells and was classified on the basis of its histopathological features. Hodgkin lymphomas are now regarded as ...
Smith Lauren B - - 2010
CONTEXT: The diagnosis of nodular lymphocyte predominant Hodgkin lymphoma involves key histopathologic and immunophenotypic findings. Appropriate classification is essential owing to the unique therapeutic and prognostic implications of this diagnosis. OBJECTIVE: To define the histologic and immunophenotypic features useful in diagnosing nodular lymphocyte predominant Hodgkin lymphoma and to identify the ...
Alam Kiran - - 2011
To establish the role of fine-needle aspiration cytology (FNAC) as a diagnostic tool for non-Hodgkins lymphoma in a resource challenged environment. This study was conducted on patients with lymphadenopathy, attending various clinics over a period of 18 months. FNAC of the enlarged lymph nodes was performed and biopsy, special stains ...
Ishimatsu Yuji - - 2010
A 70-year-old woman with a history of sinobronchial syndrome was admitted to the hospital because of a cough, sputum, and abnormal chest shadow. She was diagnosed with pulmonary mucosa-associated lymphoid tissue lymphoma (p-MALToma) based on results of a pathologic examination and the gene rearrangements in the Ig heavy chain on ...
Madan Manas - - 2010
Hodgkin's lymphoma (HL) is a malignant neoplasm of lymphoid tissues. Cervical lymphadenopathy is the most common head and neck presentation for HL. Although uncommon, extranodal HL observed at the time of diagnosis is well documented and is typically associated with generalized disease or local spread from adjacent lymph nodes. Primary ...
Nomura Eiki - - 2010
A 53-year-old woman was referred to our hospital for further examination of a rectal polypoid lesion. Colonoscopy revealed a submucosal tumor in the rectum (Ra) and a diagnosis of MALT lymphoma was made on the histological examination of the biopsy specimens and Southern blot analysis of the immunoglobulin heavy chain ...
Ho Linh - - 2010
We report the F-18 fluorodeoxyglucose positron emission tomography/computed tomography appearance of a biopsy-proven primary epidural non-Hodgkin lymphoma involving the lower cervical and upper thoracic spine with a small hypermetabolic right middle lobe nodule in a 33-year-old man. The HIV-positive patient presented with mid- to low back pain for several days, ...
Lu Rommel - - 2010
Introduction: Burkitt lymphoma (BL) originating in the skin and soft tissue is very rare. To our knowledge, this case of primary sporadic BL presenting as an isolated chest wall mass arising from the soft tissue in an adult may be the first report. Case Report: A previously healthy 33-year-old Caucasian ...
Gasparetto Taisa Davaus - - 2010
A 24-year-old male presented with productive cough associated with fever, dyspnea, and hoarseness. A chest radiograph showed nonhomogeneous air-space consolidations, mainly in the middle and inferior zones of both lungs, with cavitations and peribronchial thickening. The computed tomography scan demonstrated irregular, lobulated narrowing of the trachea, and parenchymal consolidations containing ...
Sethuraman Chitralekha C Department of Histopathology, Sheffield Children's NHS Foundation Trust, Western Bank, Sheffield, - - 2010
We aimed to evaluate the role of flowcytometric immunophenotyping (FCI) as an adjunct to histologic examination in pediatric lymphoma. We conducted a retrospective review of 39 fresh tissue samples and 2 pleural fluids submitted to the histopathology department with a clinical suspicion of lymphoma during a 4-year period, where FCI ...
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