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Chowdary Sandhya S *Department of Dermatology, Boston University School of Medicine, Boston, MA; and †Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, - - 2014
: Exogenous ochronosis (EO), although rare, is a well-known pigmentary disorder. Being extremely difficult to treat, early identification is very important, with histopathology remaining the gold standard in diagnosis. A 66-year-old woman presented with periocular and lateral neck blue-gray pigmentation, who after workup including history, physical examination, and skin biopsy ...
Weyers Wolfgang W Center for Dermatopathology, Freiburg, - - 2014
The histopathologic diagnosis of lichen sclerosus is usually facilitated by a subepidermal zone of sclerosis. In the absence of sclerosis, lichen sclerosus mostly presents itself as a psoriasiform lichenoid dermatitis that may be difficult to distinguish from other diseases. We sought to assess histopathologic findings that allow recognition of lichen ...
Aung Phyu P PP Section of Dermatopathology, Department of Dermatology, Boston University School of Medicine, Boston, - - 2014
: The progressive calcification and fragmentation of elastic fibers, primarily affecting the skin, are histopathologic features typically associated with pseudoxanthoma elasticum (PXE), pseudo-pseudo PXE, or even acquired PXE. We present a case of a 65-year-old woman, with a known history of breast carcinoma, status after wide excision (T1N0Mx) in 2010, ...
Wang Zhi Li ZL Department of Ultrasound, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Beijing 100853, China. Electronic address: - - 2014
To investigate the differences in elasticity and collagen fiber content between malignant and benign breast lesions, and to study the relationship between shear wave elasticity and the content of collagen fiber in extracellular matrix (ECM). Between May 2012 to May 2013, 106 patients with 116 breast lesions who were referred ...
Wu Yu-Hung YH Department of Dermatology, Mackay Memorial Hospital, Taipei, - - 2014
It is challenging to make a diagnosis when examining a specimen with no obvious abnormality, a situation dubbed invisible dermatoses or nothing lesion. The dermatopathologist must be very cautious and look carefully for details that differ from normal skin.A nothing lesion should be examined step by step, moving from the ...
Oczypok Elizabeth A EA Department of Pathology, University of Pittsburgh School of Medicine , Pittsburgh, PA , - - 2014
Abstract This is a case of idiopathic epithelial malignant mesothelioma in a 47-year-old mechanic. The advent of a large battery of immunochemical markers has provided new tools for the diagnosis of mesothelioma in recent years; however, immunostaining can often be misleading or inconsistent, as demonstrated in this case. This report ...
Wolf Eva-Maria EM Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria. Electronic address: - - 2014
Histologic examination of gastric biopsies is crucial for determining the cause of gastritis. This prospective multicenter study was undertaken to investigate different histologic parameters arguing in favor or against the diagnosis of reactive gastropathy and to correlate findings with patient's symptoms and endoscopic findings. A total of 1123 individuals aged ...
Stem Maxwell S MS Kellogg Eye, Department of Ophthalmology and Visual Sciences (MSS, AF, JDT), Department of Neurology (JDT), Department of Radiology (Neuroradiology) (HAP, MI), University of Michigan Medical School, Ann Arbor, - - 2014
: Bilateral lateral geniculate nucleus (LGN) injury is a rare cause of vision loss. We describe a patient with pre-eclampsia who developed profound but reversible bilateral vision loss, bilateral serous retinal detachments, and magnetic resonance imaging signs of a variant of posterior reversible encephalopathy syndrome (PRES) that affected both LGNs ...
Nayanar Sangeetha Keloth SK Department of Oncopathology, Malabar Cancer Centre, Thalassery, Kannur, - - 2014
Fiber-optic bronchoscopic biopsies yield very small bits of tissue, leading to high false negativity in lung cancer diagnosis, after paraffin embedding. The aim of the present study is to assess the diagnostic efficacy of squash smear cytology of fiber-optic bronchoscopic biopsies and to compare this with standard paraffin embedded sections ...
Yamada Takeshi - - 2013
Submucosal and lymphovascular (SM/LV) invasions of early gastric cancer (EGC) are difficult to diagnose accurately prior to endoscopic submucosal dissection (ESD), and are occasionally found in resected specimens, requiring additional gastrectomy and lymph node dissection. We performed a retrospective study to determine the risk factors for SM/LV invasions. We analyzed ...
Smith Matthew - - 2013
Objective: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) provides a reporting scheme for thyroid fine needle aspiration (FNA) and includes three indeterminate categories with different management strategies. This study analyzes indeterminate thyroid FNAs in children, and correlates these findings with the histological features. Methods: A total of 179 thyroid ...
Haklar Ugur - - 2013
The purpose of this study was to describe an arthroscopic technique for lateral parameniscal cyst (LPC) decompression with preservation of meniscal substance and to report the short- to mid-term outcome of 20 patients. All patients underwent a complete physical examination and magnetic resonance imaging (MRI) of the knee prior to ...
Jain V - - 2013
Pre-sacral epidermoid cysts are rare development cysts resulting from dysembryogenesis mostly diagnosed in middle aged women. We report a case of pre-sacral epidermoid cyst presenting with recurrent perianal sinus in young girl. Generally pre-sacral epidermoid cysts are seen in adult age group but it is rare presentation in young age ...
Gaur Ajay - - 2013
Pre-cervical inflammation is rarely seen in a newborn. Those swellings that are seen are usually congenital, such as vascular malformations, teratoma, dermoid cyst, thyroglossal cyst, cystic hygroma (abnormal lymphatic tissue), and very rarely, inflammation secondary to infection. Being able to differentiate between each condition is important because the course, treatment ...
Tomishige Hirokazu H Department of Surgery, Fujita Health University School of Medicine Banbuntane Houtokukai Hospital, 3-6-10 Otobashi Nakagawaku, Nagoya, Aichi 454-8509, - - 2013
Solitary necrotic nodule of the liver is a rare benign lesion with a completely necrotic core and a hyalinized fibrotic capsule containing elastic fibers. The pathogenetic mechanism is still unclear. We here describe a case of SNN, whose central reticulin fibers within the nodule suggest the origin as hepatocellular carcinoma ...
Savardekar A R - - 2012
Intracranial epidermoid cysts are uncommon lesions with typical radiological and operative findings. We report a midline cystic lesion in the pre-pontine cistern, with radiological features of an epidermoid, but intra-operatively yielding a thin-walled cyst with fluid contents. The cyst wall showed stratified squamous epithelium on histopathology.
Abramowitz Jessica D - - 2012
Objective: To highlight the difficulty involved in making a diagnosis of systemic mastocytosis (SM) when it manifests solely as osteoporosis.Methods: We present a detailed case report and review the literature regarding the work-up of secondary osteoporosis and the diagnosis and treatment of SM. Other cases of SM presenting as osteoporosis ...
Prabhu Shailesh M - - 2012
Recurrent small-bowel volvulus is a state of recurrent intermittent or long-standing persistent twisting of small-bowel loops around its mesentery. The association of mesenteric cysts with recurrent small-bowel volvulus as the cause or effect is a much debated issue in the literature. We report two cases of mesenteric lymphangioma and one ...
Mearin Fermín - - 2012
There are a number of reasons to establish the accurate diagnosis of irritable bowel syndrome (IBS): to relieve patient uncertainty; to avoid adverse effects of unnecessary medications or treatments; to avoid unnecessary diagnostic procedures and surgeries; to conserve limited healthcare resources; and, of course, to initiate the most appropriate treatment. ...
Saunders Sarah - - 2012
We present a case of a 30-year-old woman with learning difficulties who was found dead at home by her mother. Her body was partially naked and covered in a number of unusual skin lesions with a targetoid appearance with red erythematous centers and well-delineated halos of pallor. These lesions were ...
Portabella F - - 2012
The diagnosis of tumors and pseudotumors depends on three pillars: the clinician, the radiologist, and the pathologist. The first two can establish a presumptive diagnosis on the basis of the clinical presentation and findings on complementary tests, whereas the pathologist will have to reach the definitive diagnosis after analyzing the ...
Gauchotte Guillaume - - 2012
Endobronchial ultrasound-guided transbronchial needle aspiration has demonstrated its accuracy in the diagnostic workup of enlarged mediastinal lymph nodes. In addition to conventional smears, the use of liquid-based cytology (LBC) and cell block preparations (CBP) has been introduced more recently. The aim of our study was to determine the performance of ...
Meenakshi M - - 2012
Sarcoidosis is a granulomatous disease of unknown aetiology which primarily affects the lungs, but can affect other tissues including the central nervous system (CNS). In neurosarcoidodis, the CNS is often the only affected site, which makes a tissue diagnosis difficult. Although a clinical diagnosis of neurosarcoidosis can often be made, ...
Perman Marissa J - - 2012
1.Compare and contrast infantile hemangiomas with other vascular anomalies that may be confused clinically.2.Describe the vascular anomalies classification system according to the International Society for the Study of Vascular Anomalies (ISSVA), highlighting the differences between vascular tumors, such as infantile hemangiomas, and vascular malformations.3.Briefly review associated signs or syndromes found ...
Chandler Wells M - - 2012
Context.-Histologic examination of clinically suspicious melanocytic lesions is very sensitive and specific for the detection of malignant melanoma. Yet, the malignant potential of a small percentage of melanocytic lesions remains histologically uncertain. Molecular testing offers the potential to detect the genetic alterations that lead to malignant behavior without overt histologic ...
Wood Laura S - - 2012
To describe the pathologic and molecular characteristics of genitourinary malignancies relevant to the implications for the practice of oncology nurses. Actual cases from the author's clinical experience, original scientific papers, review articles, and pathology books. Accurate pathologic diagnosis and identification of serum and molecular markers are critical for the accurate ...
Titus Mokete J - - 2012
The advent of ultrasound in the 1970s heralded a milestone that could give real-time information about fetal abnormalities, and thereby improve diagnostic accuracy. This knowledge could not be used effectively to benefit the fetus for which it was intended. The 1980s saw science catching up with diagnostic advances, and fetal ...
Pantazopoulos Ioannis - - 2012
Malignant mesothelioma is an aggressive tumour with poor prognosis whose early diagnosis is difficult. Mesothelin, megakaryocyte potentiating factor and osteopontin have attracted attention. The aim of the present study is to provide an overview regarding these candidate biomarkers for malignant mesothelioma, and discuss their potential role in today's clinical practice.Mesothelin ...
Shankland Kate R - - 2012
Lymphomas are solid tumours of the immune system. Hodgkin's lymphoma accounts for about 10% of all lymphomas, and the remaining 90% are referred to as non-Hodgkin lymphoma. Non-Hodgkin lymphomas have a wide range of histological appearances and clinical features at presentation, which can make diagnosis difficult. Lymphomas are not rare, ...
Wang Xuan - - 2012
Brainstem glioma (BSG) is an entity which commonly occurs in pediatric patients and carries a dismal prognosis. However, the category of adult BSG has displayed considerably benign biological behavior, thus providing a unique perspective to comparatively understand the malignant features of pediatric BSG. microRNAs (miRNAs) have been associated with cancer ...
Colligris Basilio - - 2012
Glaucoma is an eye condition mainly developed from an excessive intraocular pressure. The condition tends to be inherited and may not show up until later in life. The increased pressure, can damage the optic nerve, provoking loss of vision. Without treatment, glaucoma can cause blindness within a few years; consequently ...
Levy Gillian H - - 2012
The diagnosis of pancreatic endocrine neoplasm (PEN) is often straightforward; however, cytomorphologic variants may impose a diagnostic challenge, particularly in small biopsies such as fine-needle aspiration (FNA). Here we describe prominent fine cytoplasmic vacuoles in three cases of PENs which were initially evaluated by endoscopic ultrasound-guided FNA. The clinicopathologic features ...
Russell Ginny G Institute of Health Services Research, Peninsula College of Medicine and Dentistry, Exeter, UK. - - 2012
Jutel and Nettleton (2011) discuss diagnosis as not only a major classification tool for medicine but also an interactive social process that itself may have ramifications for health. Consideration of diagnosis as a social determinant of health outcomes led to the formulation of our research question: Can we detect a ...
Quin Godfrey - - 2012
Most acute cases of central serous chorioretinopathy resolve spontaneously with minimal visual impairment. The small percentage of eyes developing chronic or recurrent disease that do warrant treatment are often difficult to control. Emergent investigations and treatments have added to the established options available to manage these cases. Optical coherence tomography ...
Jain Dharmendra - - 2012
Management of Aplastic Anemia (AA) is, to an extent, based on the differential diagnosis whether acquired or constitutional [1]. Fanconi Anemia (FA) is the most common cause of constitutional AA. Chromosomal Breakage Study (CBS) using Mitomycin-C is widely used for differential diagnosis of AA. The interpretation of results, however, may ...
Altay Tamer - - 2012
Advanced technology and improved understanding of the natural history of arteriovenous malformations (AVMs) led to the reconsideration of the management of these lesions, which once comprised purely microsurgical removal. A multidisciplinary approach for both the evaluation and treatment of AVMs has gained acceptance within the past few decades. Treatment options ...
Shen Steven S - - 2012
SUMMARY: Frozen section diagnosis provides critical information for immediate surgical management decision making. Over the last several years, there have been some significant advances in treatment of genitourinary cancer, particularly with regard to surgical techniques. These changes in turn impact the type and frequency of intraoperative frozen section requests. In ...
Avon Sylvie-Louise - - 2012
Proper management of an oral mucosal lesion begins with diagnosis, and the gold standard for diagnosing disease, oral or otherwise, is tissue biopsy. The oral environment, which is moist and confined, poses challenges for collecting a viable tissue sample that will be suitable for diagnosis. These challenges are further compounded ...
Kharma Mohamed Yasser - - 2012
Proliferative verrucous leukoplakia is multifocal and progressive lesion with a high rate of malignant transformation. This short review highlights the diagnosis, traditional treatment and the current management of the disease. A MEDLINE search for the specific English word including proliferative verrucous leukoplakia in the last two years (2009-2010). This study ...
Prieto Victor G - - 2012
Of all pathology fields, the analysis of melanocytic lesions has one of the highest rates of review for legal reasons, particularly regarding the distinction between nevus and melanoma. Among the most frequently involved are desmoplastic melanoma, nevoid melanoma, and Spitz nevus versus spitzoid melanoma. Therefore, it follows that pathologists and ...
Lallas Aimilios - - 2012
Granuloma faciale (GF) is a rare benign inflammatory dermatosis that usually develops as a solitary brownish-red plaque on the face. It clinically mimics and is often misinterpreted as, sarcoidosis, lupus erythematosus, lupus vulgaris, lymphoma or basal cell carcinoma.Dermoscopy, which is valuable for evaluation and differentiation between malignant and benign skin ...
De Bisschop M B - - 2012
PURPOSE OF REVIEW: This article aims to make a review of the up-to-date knowledge on anaphylaxis and outline the recent advances on pathophysiology, diagnosis, and management of anaphylaxis. RECENT FINDINGS: New data confirm the increase in prevalence of anaphylaxis and emphasize immunopathologic mechanisms. However, anaphylaxis is often underdiagnosed and guidelines ...
Moscarella Elvira - - 2012
The correct assessment of a solitary red nodule in clinical practice is of crucial importance, amelanotic melanoma being the most important differential diagnosis. Dermoscopy is nowadays a pivotal tool in the management of skin tumors, however it has some limitations in the evaluation of nonpigmented lesions, in which the diagnosis ...
Schrier Samantha A SA Division of Human Genetics, The Children's Hospital of Philadelphia, and Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, - - 2012
Coffin-Siris syndrome (CSS) is a rare, clinically heterogeneous disorder often considered in the setting of cognitive/developmental delay and 5th finger/nail hypoplasia. Due to the clinical variability of facial and other features, this diagnosis is often difficult to confirm clinically and the existence of this disorder as a specific diagnosis has ...
Dumonceau Jean-Marc - - 2012
Sampling at ERCP may be performed at the level of the papilla or of the biliopancreatic ducts. Samples collected at the level of the biliopancreatic ducts allow for diagnosing malignancy with a specificity close to 100% but present a moderate sensitivity in most studies. In this article, the different aspects ...
Strowd Lindsay Chaney - - 2012
Abstract This is a review article summarizing the diagnosis, evaluation, and management of dermatomyositis (DM). Key clinical features and variations in clinical presentation of DM are highlighted, and the evidence based treatments for this condition are discussed.
Kokkonouzis Ioannis - - 2012
Endobronchial ultrasound (EBUS) technology is a relatively new bronchoscopic method of visualizing the tracheobronchial tree, the surrounding pulmonary parenchyma, and the mediastinal structures, with a particular role in lung cancer diagnosis, staging, and treatment. There are 2 types of probes used in EBUS: the peripheral or radial probe (RP) and ...
Shaida N - - 2012
Ultrasound forms an important part of the assessment of the testicle. Nevertheless, there are a number of situations in which clinical and radiological assessment is unable to provide a definitive diagnosis of a testicular lump. In these situations, historically, either open biopsy or orchidectomy has been performed. Ultrasound-guided percutaneous testicular ...
Huang D Y - - 2012
The aim of this review is to illustrate the potential of different and newer ultrasound techniques beyond conventional B-mode imaging, including colour Doppler ultrasound, contrast-enhanced ultrasound (CEUS) and tissue elastography, in the characterisation of both benign and malignant intratesticular lesions. Normally, testicular malignancies, either primary or secondary, demonstrate an increase ...
Kurien Matthew - - 2012
Recent studies highlight the role of duodenal bulb biopsy in the diagnosis of celiac disease. To determine whether a targeted duodenal bulb biopsy in addition to distal duodenal biopsies is the optimal strategy to identify villous atrophy. Prospective cohort study. Tertiary-care referral center. Seventy-seven patients undergoing clinically indicated EGD with ...
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